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Aliases for SLC25A28 Gene

Aliases for SLC25A28 Gene

  • Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 28 2 3
  • Mitochondrial RNA-Splicing Protein 3/4 Homolog 3 4
  • Solute Carrier Family 25, Member 28 2 3
  • Mitochondrial Iron Transporter 2 3 4
  • Mitoferrin 2 2 3
  • HMRS3/4 3 4
  • NPD016 3 6
  • MRS3/4 3 4
  • MRS4L 3 6
  • MFRN2 3 4
  • Mitochondrial RNA Splicing Protein 3/4 3
  • Putative Mitochondrial Solute Carrier 3
  • Solute Carrier Family 25 Member 28 4
  • Mitoferrin-2 3

External Ids for SLC25A28 Gene

Summaries for SLC25A28 Gene

GeneCards Summary for SLC25A28 Gene

SLC25A28 (Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 28) is a Protein Coding gene. Among its related pathways are Metabolism and Mitochondrial Iron-Sulfur Cluster Biogenesis. An important paralog of this gene is SLC25A37.

UniProtKB/Swiss-Prot for SLC25A28 Gene

  • Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A28 Gene

Genomics for SLC25A28 Gene

Genomic Location for SLC25A28 Gene

Start:
99,610,518 bp from pter
End:
99,659,286 bp from pter
Size:
48,769 bases
Orientation:
Minus strand

Genomic View for SLC25A28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A28 Gene

Regulatory Elements for SLC25A28 Gene

Proteins for SLC25A28 Gene

  • Protein details for SLC25A28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A46-MFRN2_HUMAN
    Recommended name:
    Mitoferrin-2
    Protein Accession:
    Q96A46
    Secondary Accessions:
    • Q4VBZ0
    • Q5T777
    • Q86VX5
    • Q969G8
    • Q9H2J3

    Protein attributes for SLC25A28 Gene

    Size:
    364 amino acids
    Molecular mass:
    39272 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47312.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16900.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A28 Gene

Proteomics data for SLC25A28 Gene at MOPED

Post-translational modifications for SLC25A28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A28 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A28 Gene

Domains for SLC25A28 Gene

Gene Families for SLC25A28 Gene

Protein Domains for SLC25A28 Gene

UniProtKB/Swiss-Prot:

MFRN2_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q96A46
Similarity:
  • Contains 3 Solcar repeats.:
    • Q96A46
genes like me logo Genes that share domains with SLC25A28: view

Function for SLC25A28 Gene

Molecular function for SLC25A28 Gene

UniProtKB/Swiss-Prot Function: Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

Phenotypes for SLC25A28 Gene

GenomeRNAi human phenotypes for SLC25A28:
genes like me logo Genes that share phenotypes with SLC25A28: view

miRNA for SLC25A28 Gene

miRTarBase miRNAs that target SLC25A28

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A28 Gene

Localization for SLC25A28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A28 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A28 Gene COMPARTMENTS Subcellular localization image for SLC25A28 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
chloroplast 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A28: view

Pathways for SLC25A28 Gene

genes like me logo Genes that share pathways with SLC25A28: view

Pathways by source for SLC25A28 Gene

2 Reactome pathways for SLC25A28 Gene

Interacting Proteins for SLC25A28 Gene

Gene Ontology (GO) - Biological Process for SLC25A28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0055072 iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with SLC25A28: view

Compounds for SLC25A28 Gene

(2) HMDB Compounds for SLC25A28 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
Iron
  • Armco iron
7439-89-6
genes like me logo Genes that share compounds with SLC25A28: view

Transcripts for SLC25A28 Gene

Unigene Clusters for SLC25A28 Gene

Solute carrier family 25 (mitochondrial iron transporter), member 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A28 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for SLC25A28 Gene

GeneLoc Exon Structure for
SLC25A28
ECgene alternative splicing isoforms for
SLC25A28

Expression for SLC25A28 Gene

mRNA expression in normal human tissues for SLC25A28 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A28 Gene

SOURCE GeneReport for Unigene cluster for SLC25A28 Gene Hs.403790

mRNA Expression by UniProt/SwissProt for SLC25A28 Gene

Q96A46-MFRN2_HUMAN
Tissue specificity: Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart.
genes like me logo Genes that share expressions with SLC25A28: view

Orthologs for SLC25A28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A28 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A28 36
  • 95.42 (n)
  • 98.35 (a)
SLC25A28 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 100 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
SLC25A28 36
  • 94.87 (n)
  • 99.73 (a)
mouse
(Mus musculus)
Mammalia Slc25a28 36
  • 92.4 (n)
  • 97.53 (a)
Slc25a28 16
Slc25a28 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A28 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A28 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a28 36
  • 92.86 (n)
  • 96.98 (a)
chicken
(Gallus gallus)
Aves SLC25A28 36
  • 81.84 (n)
  • 88.46 (a)
SLC25A28 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A28 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28756 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a28 36
  • 79.85 (n)
  • 85.62 (a)
Str.17759 36
zebrafish
(Danio rerio)
Actinopterygii slc25a28 36
  • 73.27 (n)
  • 80.2 (a)
slc25a28 37
  • 66 (a)
OneToMany
slc25a28 37
  • 63 (a)
OneToMany
wufc48b02 36
fruit fly
(Drosophila melanogaster)
Insecta mfrn 37
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mfn-1 37
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS3 37
  • 38 (a)
ManyToMany
MRS4 37
  • 39 (a)
ManyToMany
MRS4 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3760 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for SLC25A28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A28 Gene

ENSEMBL:
Gene Tree for SLC25A28 (if available)
TreeFam:
Gene Tree for SLC25A28 (if available)

Paralogs for SLC25A28 Gene

Paralogs for SLC25A28 Gene

Selected SIMAP similar genes for SLC25A28 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A28: view

Variants for SLC25A28 Gene

Sequence variations from dbSNP and Humsavar for SLC25A28 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs880568 -- 99,612,654(+) ACTCA(C/T)TGAGG intron-variant
rs888209 -- 99,612,286(-) GGGAG(C/T)CTCCT intron-variant
rs1035214 -- 99,628,434(-) TAAAC(A/T)TTCAA intron-variant
rs1035215 -- 99,626,847(-) TGGGA(C/T)TGAAA intron-variant
rs1035216 -- 99,626,846(-) GGGAC(A/T)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A28 Gene

Variant ID Type Subtype PubMed ID
nsv831958 CNV Gain 17160897
nsv7515 CNV Insertion 18451855

Relevant External Links for SLC25A28 Gene

HapMap Linkage Disequilibrium report
SLC25A28

Disorders for SLC25A28 Gene

(2) University of Copenhagen DISEASES for SLC25A28 Gene

Relevant External Links for SLC25A28

Genetic Association Database (GAD)
SLC25A28
Human Genome Epidemiology (HuGE) Navigator
SLC25A28
genes like me logo Genes that share disorders with SLC25A28: view

No data available for UniProtKB/Swiss-Prot for SLC25A28 Gene

Publications for SLC25A28 Gene

  1. Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4. (PMID: 11297739) Li F.-Y. … Suomalainen A. (FEBS Lett. 2001) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for SLC25A28 Gene

Sources for SLC25A28 Gene

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