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Aliases for SLC25A28 Gene

Aliases for SLC25A28 Gene

  • Solute Carrier Family 25 Member 28 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 28 2 3 5
  • Mitochondrial RNA-Splicing Protein 3/4 Homolog 3 4
  • Solute Carrier Family 25, Member 28 2 3
  • Mitochondrial Iron Transporter 2 3 4
  • Mitoferrin 2 2 3
  • HMRS3/4 3 4
  • MRS3/4 3 4
  • MFRN2 3 4
  • Mitochondrial RNA Splicing Protein 3/4 3
  • Putative Mitochondrial Solute Carrier 3
  • NPD016 3
  • MRS4L 3

External Ids for SLC25A28 Gene

Previous GeneCards Identifiers for SLC25A28 Gene

  • GC10M101034
  • GC10M101360
  • GC10M094997

Summaries for SLC25A28 Gene

GeneCards Summary for SLC25A28 Gene

SLC25A28 (Solute Carrier Family 25 Member 28) is a Protein Coding gene. Among its related pathways are Metabolism and Mitochondrial iron-sulfur cluster biogenesis. An important paralog of this gene is SLC25A37.

UniProtKB/Swiss-Prot for SLC25A28 Gene

  • Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A28 Gene

Genomics for SLC25A28 Gene

Regulatory Elements for SLC25A28 Gene

Enhancers for SLC25A28 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A28 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A28 Gene

Chromosome:
10
Start:
99,610,518 bp from pter
End:
99,659,339 bp from pter
Size:
48,822 bases
Orientation:
Minus strand

Genomic View for SLC25A28 Gene

Genes around SLC25A28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A28 Gene

Proteins for SLC25A28 Gene

  • Protein details for SLC25A28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A46-MFRN2_HUMAN
    Recommended name:
    Mitoferrin-2
    Protein Accession:
    Q96A46
    Secondary Accessions:
    • Q4VBZ0
    • Q5T777
    • Q86VX5
    • Q969G8
    • Q9H2J3

    Protein attributes for SLC25A28 Gene

    Size:
    364 amino acids
    Molecular mass:
    39272 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47312.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16900.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A28 Gene

Proteomics data for SLC25A28 Gene at MOPED

Post-translational modifications for SLC25A28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A28 Gene

Domains & Families for SLC25A28 Gene

Gene Families for SLC25A28 Gene

Protein Domains for SLC25A28 Gene

Suggested Antigen Peptide Sequences for SLC25A28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A46

UniProtKB/Swiss-Prot:

MFRN2_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A28: view

Function for SLC25A28 Gene

Molecular function for SLC25A28 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).
genes like me logo Genes that share phenotypes with SLC25A28: view

Animal Models for SLC25A28 Gene

MGI Knock Outs for SLC25A28:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A28

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A28 Gene

Localization for SLC25A28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A28 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Note=Isoform 1 and isoform 2 are both localized in the mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A28 Gene COMPARTMENTS Subcellular localization image for SLC25A28 gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A28 Gene

Pathways & Interactions for SLC25A28 Gene

genes like me logo Genes that share pathways with SLC25A28: view

Pathways by source for SLC25A28 Gene

2 Reactome pathways for SLC25A28 Gene

Interacting Proteins for SLC25A28 Gene

Gene Ontology (GO) - Biological Process for SLC25A28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with SLC25A28: view

No data available for SIGNOR curated interactions for SLC25A28 Gene

Drugs & Compounds for SLC25A28 Gene

(1) Drugs for SLC25A28 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(1) Additional Compounds for SLC25A28 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SLC25A28: view

Transcripts for SLC25A28 Gene

Unigene Clusters for SLC25A28 Gene

Solute carrier family 25 (mitochondrial iron transporter), member 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A28 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for SLC25A28 Gene

GeneLoc Exon Structure for
SLC25A28
ECgene alternative splicing isoforms for
SLC25A28

Expression for SLC25A28 Gene

mRNA expression in normal human tissues for SLC25A28 Gene

Protein differential expression in normal tissues from HIPED for SLC25A28 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A28 Gene



SOURCE GeneReport for Unigene cluster for SLC25A28 Gene Hs.403790

mRNA Expression by UniProt/SwissProt for SLC25A28 Gene

Q96A46-MFRN2_HUMAN
Tissue specificity: Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with SLC25A28: view

Protein tissue co-expression partners for SLC25A28 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC25A28 Gene

Orthologs for SLC25A28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A28 35
  • 95.42 (n)
  • 98.35 (a)
SLC25A28 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A28 35
  • 94.87 (n)
  • 99.73 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc25a28 35
  • 92.4 (n)
  • 97.53 (a)
Slc25a28 16
Slc25a28 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a28 35
  • 92.86 (n)
  • 96.98 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A28 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A28 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A28 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A28 35
  • 81.84 (n)
  • 88.46 (a)
SLC25A28 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A28 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a28 35
  • 79.85 (n)
  • 85.62 (a)
Str.17759 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.28756 35
zebrafish
(Danio rerio)
Actinopterygii slc25a28 35
  • 73.27 (n)
  • 80.2 (a)
wufc48b02 35
slc25a28 36
  • 66 (a)
OneToMany
slc25a28 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mfrn 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mfn-1 36
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS3 36
  • 38 (a)
ManyToMany
MRS4 36
  • 39 (a)
ManyToMany
MRS4 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3760 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for SLC25A28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A28 Gene

ENSEMBL:
Gene Tree for SLC25A28 (if available)
TreeFam:
Gene Tree for SLC25A28 (if available)

Paralogs for SLC25A28 Gene

Paralogs for SLC25A28 Gene

(1) SIMAP similar genes for SLC25A28 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A28: view

Variants for SLC25A28 Gene

Sequence variations from dbSNP and Humsavar for SLC25A28 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3215924 -- 99,610,266(+) TGCGC(-/TACCGC)CCTAG downstream-variant-500B
rs3740081 -- 99,611,611(+) CCAGC(C/T)AGTTC intron-variant
rs2024504 -- 99,616,531(-) GCCCA(C/T)GTATA intron-variant, utr-variant-5-prime
rs2052317 -- 99,621,807(-) AGAAG(A/G)GCTAA intron-variant, upstream-variant-2KB
rs2052318 -- 99,621,762(-) TCCAA(A/G)GAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A28 Gene

Variant ID Type Subtype PubMed ID
nsv831958 CNV Gain 17160897
nsv7515 CNV Insertion 18451855

Variation tolerance for SLC25A28 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC25A28 Gene

Disorders for SLC25A28 Gene

Relevant External Links for SLC25A28

Genetic Association Database (GAD)
SLC25A28
Human Genome Epidemiology (HuGE) Navigator
SLC25A28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A28

No disorders were found for SLC25A28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A28 Gene

Publications for SLC25A28 Gene

  1. Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4. (PMID: 11297739) Li F.-Y. … Suomalainen A. (FEBS Lett. 2001) 2 3 4 67
  2. Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. (PMID: 24737748) Whiffin N. … Dunlop M.G. (Hum. Mol. Genet. 2014) 3
  3. Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy. (PMID: 23135267) Hung H.I. … Nieminen A.L. (J. Biol. Chem. 2013) 3
  4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  5. Genetic determinants of plasma I^a88-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. (PMID: 23279374) Athanasiadis G. … Soria J.M. (J. Thromb. Haemost. 2013) 3

Products for SLC25A28 Gene

Sources for SLC25A28 Gene

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