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Aliases for SLC25A27 Gene

Aliases for SLC25A27 Gene

  • Solute Carrier Family 25, Member 27 2 3
  • UCP4 3 4 6
  • UCP 4 3 4
  • Mitochondrial Uncoupling Protein 4 3
  • Solute Carrier Family 25 Member 27 4
  • Uncoupling Protein 4 3

External Ids for SLC25A27 Gene

Summaries for SLC25A27 Gene

Entrez Gene Summary for SLC25A27 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

GeneCards Summary for SLC25A27 Gene

SLC25A27 (Solute Carrier Family 25, Member 27) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for SLC25A27 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain

Gene Wiki entry for SLC25A27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A27 Gene

Genomics for SLC25A27 Gene

Genomic Location for SLC25A27 Gene

46,652,915 bp from pter
46,678,193 bp from pter
25,279 bases
Plus strand

Genomic View for SLC25A27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A27 Gene

Regulatory Elements for SLC25A27 Gene

Proteins for SLC25A27 Gene

  • Protein details for SLC25A27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial uncoupling protein 4
    Protein Accession:
    Secondary Accessions:
    • F5GWR4
    • Q5VTS9
    • Q8N518

    Protein attributes for SLC25A27 Gene

    323 amino acids
    Molecular mass:
    36064 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A27 Gene


neXtProt entry for SLC25A27 Gene

Proteomics data for SLC25A27 Gene at MOPED

Post-translational modifications for SLC25A27 Gene

No Post-translational modifications

Other Protein References for SLC25A27 Gene

No data available for DME Specific Peptides for SLC25A27 Gene

Domains for SLC25A27 Gene

Gene Families for SLC25A27 Gene

Protein Domains for SLC25A27 Gene


  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • O95847
  • Contains 3 Solcar repeats.:
    • O95847
genes like me logo Genes that share domains with SLC25A27: view

Function for SLC25A27 Gene

Molecular function for SLC25A27 Gene

UniProtKB/Swiss-Prot Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain
genes like me logo Genes that share phenotypes with SLC25A27: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC25A27 Gene

Localization for SLC25A27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A27 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A27 Gene COMPARTMENTS Subcellular localization image for SLC25A27 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 10025957
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0043025 neuronal cell body IEA --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with SLC25A27: view

Pathways for SLC25A27 Gene

genes like me logo Genes that share pathways with SLC25A27: view

Pathways by source for SLC25A27 Gene

1 BioSystems pathway for SLC25A27 Gene

Interacting Proteins for SLC25A27 Gene

Selected Interacting proteins: O95847-UCP4_HUMAN for SLC25A27 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC25A27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 10025957
GO:0006810 transport --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0010917 negative regulation of mitochondrial membrane potential IEA --
GO:0015992 proton transport TAS --
genes like me logo Genes that share ontologies with SLC25A27: view

Compounds for SLC25A27 Gene

(2) Novoseek inferred chemical compound relationships for SLC25A27 Gene

Compound -log(P) Hits PubMed IDs
hydrogen 21.2 1
calcium 15.2 1
genes like me logo Genes that share compounds with SLC25A27: view

Transcripts for SLC25A27 Gene

Unigene Clusters for SLC25A27 Gene

Solute carrier family 25, member 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A27 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for SLC25A27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A27 Gene

mRNA expression in normal human tissues for SLC25A27 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC25A27 Gene

SOURCE GeneReport for Unigene cluster for SLC25A27 Gene Hs.40510

mRNA Expression by UniProt/SwissProt for SLC25A27 Gene

Tissue specificity: Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra
genes like me logo Genes that share expressions with SLC25A27: view

Orthologs for SLC25A27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A27 36
  • 99.79 (n)
  • 99.69 (a)
SLC25A27 37
  • 100 (a)
(Bos Taurus)
Mammalia SLC25A27 36
  • 92.16 (n)
  • 94.74 (a)
SLC25A27 37
  • 95 (a)
(Canis familiaris)
Mammalia SLC25A27 36
  • 94.63 (n)
  • 97.21 (a)
SLC25A27 37
  • 97 (a)
(Mus musculus)
Mammalia Slc25a27 36
  • 88.99 (n)
  • 96.23 (a)
Slc25a27 16
Slc25a27 37
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A27 37
  • 67 (a)
(Rattus norvegicus)
Mammalia Slc25a27 36
  • 88.26 (n)
  • 94.97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a27 36
  • 71.68 (n)
  • 74.84 (a)
Str.20468 36
(Danio rerio)
Actinopterygii slc25a27 36
  • 67.31 (n)
  • 69.26 (a)
slc25a27 37
  • 69 (a)
zgc63899 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009603 36
  • 56 (n)
  • 58.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ucp4A 36
  • 55.78 (n)
  • 58 (a)
Ucp4A 37
  • 52 (a)
(Caenorhabditis elegans)
Secernentea ucp-4 36
  • 55.25 (n)
  • 52.4 (a)
ucp-4 37
  • 48 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G14140 36
  • 51.34 (n)
  • 44.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1001 36
Species with no ortholog for SLC25A27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A27 Gene

Gene Tree for SLC25A27 (if available)
Gene Tree for SLC25A27 (if available)

Paralogs for SLC25A27 Gene

genes like me logo Genes that share paralogs with SLC25A27: view

Variants for SLC25A27 Gene

Sequence variations from dbSNP and Humsavar for SLC25A27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs953062 -- 46,658,616(+) GCAAG(A/G)AGAGT intron-variant
rs2016368 -- 46,665,948(-) GTCAC(A/T)TTCCA intron-variant
rs3757241 -- 46,655,961(-) CCTAG(A/G)GCTGT synonymous-codon, reference, utr-variant-5-prime, nc-transcript-variant
rs3778483 -- 46,659,363(-) TAGCA(C/G)AGCAG intron-variant
rs3778484 -- 46,659,277(-) AGAAT(C/T)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A27 Gene

Variant ID Type Subtype PubMed ID
nsv885868 CNV Gain 21882294

Relevant External Links for SLC25A27 Gene

HapMap Linkage Disequilibrium report

Disorders for SLC25A27 Gene

Relevant External Links for SLC25A27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC25A27: view

No data available for UniProtKB/Swiss-Prot for SLC25A27 Gene

Publications for SLC25A27 Gene

  1. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. (PMID: 10025957) Mao W. … Pan G. (FEBS Lett. 1999) 2 3 4 23
  2. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PMID: 17066476) Yasuno K. … Tamiya G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 49
  3. A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis. (PMID: 19536655) Szolnoki Z. … Somogyvari F. (Neuromolecular Med. 2009) 3 23 49
  4. Specific sequence of motifs of mitochondrial uncoupling proteins. (PMID: 10772343) Jezek P. … UrbA!nkovA! E. (IUBMB Life 2000) 2 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for SLC25A27 Gene

Sources for SLC25A27 Gene

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