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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A27 Gene

protein-coding   GIFtS: 51
GCID: GC06P046620

solute carrier family 25, member 27

 Explore 9 diseases affiliated with
SLC25A27 via our new
 Human Malady Compendium 
Biological research products
for SLC25A27
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 25, Member 271 2     Mitochondrial Uncoupling Protein 42
UCP41 2 3 5     Uncoupling Protein 42
UCP 42 3     Solute Carrier Family 25 Member 273
FLJ335521     

External Ids:    HGNC: 210651   Entrez Gene: 94812   Ensembl: ENSG000001532917   OMIM: 6137255   UniProtKB: O958473   

Export aliases for SLC25A27 gene to outside databases

Previous GC identifers: GC00U912988 GC06P046667 GC06P046728 GC06P046343


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A27:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins
(MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as
the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial
membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the
mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact
methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs.
Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental
conditions. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane,
thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
May play a role in thermoregulatory heat production and metabolism in brain

Gene Wiki entry for SLC25A27


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A27 gene promoter:
         ISGF-3   HOXA3   Brachyury   MIF-1   PPAR-alpha   FAC1   Ik-2   Cart-1   Pax-4a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A27 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

SLC25A27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A27 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P046620:  view genomic region     (about GC identifiers)

Start:
46,620,678 bp from pter      End:
46,649,356 bp from pter
Size:
28,679 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847 (See protein sequence)
Recommended Name: Mitochondrial uncoupling protein 4  
Size: 323 amino acids; 36064 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: F5GWR4 Q5VTS9 Q8N518
Alternative splicing: 2 isoforms:  O95847-1   O95847-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC25A27: NX_O95847

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95847

  • SLC25A27 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001190980.1  NP_001190981.1  NP_004268.3  

    ENSEMBL proteins: 
     ENSP00000360398   ENSP00000391223   ENSP00000408120   ENSP00000396450   ENSP00000402082  
     ENSP00000412024   ENSP00000412223  

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    Uscn Proteins for SLC25A27

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS10025957
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0043025neuronal cell body IEA--
    GO:0045177apical part of cell IEA--


    SLC25A27 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC25A27 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry O95847

    ProtoNet protein and cluster: O95847

    UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847
    Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane,
    thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
    May play a role in thermoregulatory heat production and metabolism in brain

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    2 GenomeRNAi human phenotypes for SLC25A27:
     Decreased circadian period len  Increased number of cells in m 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.76


    1 BioSystems Pathway for SLC25A27 
        Electron Transport Chain


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC25A27

    1 Interacting protein for SLC25A27 (O958473) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAR1AP106443I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS10025957
    GO:0006810transport IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0035356cellular triglyceride homeostasis IEA--
    GO:0043066negative regulation of apoptotic process IEA--


    SLC25A27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC25A27 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC25A27
    2 Novoseek chemical compound relationships for SLC25A27 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydrogen 21.2 1 10736318 (1)
    calcium 15.2 1 17035241 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC25A27 / UCP4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for SLC25A27 gene (3 alternative transcripts): 
    NM_001204051.1  NM_001204052.1  NM_004277.4  

    Unigene Cluster for SLC25A27:

    Solute carrier family 25, member 27
    Hs.40510  [show with all ESTs]
    Unigene Representative Sequence: NM_004277
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371347(uc011dwb.2 uc003oyh.3 uc003oyg.3 uc011dwc.2 uc003oyi.3)
    ENST00000425120 ENST00000498445 ENST00000437459 ENST00000444329 ENST00000417490
    ENST00000465620 ENST00000411689 ENST00000452689

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    Additional cDNA sequence: 

    AF110532.1 AK291427.1 AK295233.1 AK302906.1 AK315940.1 AY358711.1 BC033091.1 

    8 DOTS entries:

    DT.100818364  DT.214109  DT.87016596  DT.100818363  DT.100020910  DT.40120289  DT.121363427  DT.75169502 

    24/82 AceView cDNA sequences (see all 82):

    CK429468 BU686290 AI683883 CA429578 AA857932 AW161176 CD242871 AW511808 
    AV654180 Z42553 CB241965 AW055254 BG925533 BM682104 AW161833 BG696637 
    BG149893 AW157496 BG149655 AY358711 AW157357 AW162249 BM047096 AW779950 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A27 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
    SP1:                          -     -           -                                                                                       
    SP2:                                                                                            -           -     -     -               
    SP3:                          -     -           -                             -     -     -     -                                       
    SP4:                                            -                                                                                       
    SP5:                                                                          -     -     -     -                                       


    ECgene alternative splicing isoforms for SLC25A27

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTGATATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SLC25A27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC25A27

    SOURCE GeneReport for Unigene cluster: Hs.40510

    UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847
    Tissue specificity: Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal
    chord, corpus callosum and substantia nigra

        SABiosciences Expression via Pathway-Focused PCR Array including SLC25A27: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A27 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    African clawed frog
    (Xenopus laevis)
    Amphibia 480112652   -- 73.84(n)    48011265 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638992 hypothetical protein MGC63899 74.41(n)   393312  BC053139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ucp4A1 CG6492-PA 55.78(n)
    58(a)
      32764  NM_001201735.1  NP_001188664.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ucp-41 Protein UCP-4 55.48(n)
    51.71(a)
      179315  NM_073013.4  NP_505414.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G141401 Mitochondrial substrate carrier family protein 51.34(n)
    44.3(a)
      837973  NM_101279.2  NP_172866.1 
    rice
    (Oryza sativa)
    Liliopsida --
    --
    mitochondrial carrier protein, putative, expressed...
    mitochondrial carrier protein, putative, expressed...
    42(a)
    31(a)
    1 ↔ 1
    possible ortholog
    4(22191917-22194231)
    12(21192352-21195968)


    ENSEMBL Gene Tree for SLC25A27 (if available)
    TreeFam Gene Tree for SLC25A27 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A27 gene
    SLC25A112  ENSG000002626602  UCP32  UCP12  UCP22  SLC25A102  SLC25A302  SLC25A142  
    12 SIMAP similar genes for SLC25A27 using alignment to 7 protein entries:     UCP4_HUMAN (see all proteins):
    SLC25A22    SLC25A30    UCP1    SLC25A14    SLC25A11    SLC25A10
    UCP2    SLC25A35    UCP3    SLC25A34    SLC25A21    SLC25A1

    SLC25A27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/390 NCBI SNPs in SLC25A27 are shown (see all 390    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785066071,2
    C,F,--46618800(+) CAGTCA/GATGGA 4 -- int1 us2k11Minor allele frequency- G:0.03NA 120
    rs1422346411,2
    --46618978(+) AAACAC/TGCAAG 4 -- int1 us2k10--------
    rs1872336981,2
    --46619077(+) TCCTAC/TGACAA 4 -- us2k1 int10--------
    rs1463784541,2
    --46619092(+) TAGCCA/GTAAAA 4 -- us2k1 int10--------
    rs1485606121,2
    --46619249(+) ATACAC/TTAAAT 4 -- int1 us2k10--------
    rs1928599351,2
    --46619270(+) CAGCTG/TGTGTG 4 -- int1 us2k10--------
    rs1846632711,2
    --46619301(+) TTTCAA/TCTTAG 4 -- us2k1 int10--------
    rs1888035771,2
    --46619373(+) TGATCA/GGTGGT 4 -- us2k1 int10--------
    rs1429024611,2
    --46619389(+) AATGCC/TACTAC 4 -- us2k1 int10--------
    rs1928880571,2
    --46619395(+) ACTACA/GTATAA 4 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for SLC25A27 (46620678 - 46649356 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC25A27: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC25A27 for disorders           About GeneDecksing

    OMIM gene information: 613725    OMIM disorders: --

    9 diseases for SLC25A27:    About MalaCards
    juvenile myoclonic epilepsy    corpus callosum    multiple sclerosis    migraine
    breast carcinoma    obesity    schizophrenia    carcinoma
    neuronitis

    Genetic Association Database (GAD): SLC25A27
    Human Genome Epidemiology (HuGE) Navigator: SLC25A27 (9 documents)

    Export disorders for SLC25A27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A27 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with SLC25A27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. (PubMed id 10025957)1, 2, 3, 9 Mao W....Pan G. (1999)
    2. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PubMed id 16378686)1, 4 Norberg A....Holmberg M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Specific sequence of motifs of mitochondrial uncoupling proteins. (PubMed id 10772343)1, 3 Jezek P. and Urbankova E. (2000)
    6. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PubMed id 17066476)1, 9 Yasuno K....Tamiya G. (2007)
    7. A homozygous genetic variant of mitochondrial uncoupl ing protein 4 exerts protection against the occurrence of multiple sclerosis. (PubMed id 19536655)1, 9 Szolnoki Z....Somogyvari F. (2009)
    8. Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells. (PubMed id 17035241)1, 9 Chan S.L....Mattson M.P. (2006)
    9. Uncoupling protein-4 (UCP4) increases ATP supply by in teracting with mitochondrial Complex II in neuroblastoma cells. (PubMed id 22427795)1 Ho P.W....Ho S.L. (2012)
    10. UCP4 is a target effector of the NF-kB c-Rel prosurviv al pathway against oxidative stress. (PubMed id 22580300)1 Ho J.W....Ho S.L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9481 HGNC: 21065 AceView: SLC25A27 Ensembl:ENSG00000153291 euGenes: HUgn9481
    ECgene: SLC25A27 H-InvDB: SLC25A27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC25A27 gene:
    Search GeneIP for patents involving SLC25A27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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