Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC25A27 Gene

protein-coding   GIFtS: 52
GCID: GC06P046620

Solute Carrier Family 25, Member 27

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 25, Member 271 2
UCP42 3 5
UCP 42 3
Mitochondrial Uncoupling Protein 42
Uncoupling Protein 42
Solute Carrier Family 25 Member 273

External Ids:    HGNC: 210651   Entrez Gene: 94812   Ensembl: ENSG000001532917   OMIM: 6137255   UniProtKB: O958473   

Export aliases for SLC25A27 gene to outside databases

Previous GC identifers: GC00U912988 GC06P046667 GC06P046728 GC06P046343


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC25A27 Gene:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins
(MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred
to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer
mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane.
They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the
different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous
protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically
modulated by various environmental conditions. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, Feb 2011)

GeneCards Summary for SLC25A27 Gene:
SLC25A27 (solute carrier family 25, member 27) is a protein-coding gene. An important paralog of this gene is UCP3.

UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the
form of heat. May play a role in thermoregulatory heat production and metabolism in brain

Gene Wiki entry for SLC25A27 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A27 gene promoter:
         ISGF-3   HOXA3   Brachyury   MIF-1   PPAR-alpha   FAC1   Ik-2   Cart-1   Pax-4a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A27 promoter sequence
   Search Chromatin IP Primers for SLC25A27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

SLC25A27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A27 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P046620:  view genomic region     (about GC identifiers)

Start:
46,620,652 bp from pter      End:
46,645,930 bp from pter
Size:
25,279 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847 (See protein sequence)
Recommended Name: Mitochondrial uncoupling protein 4  
Size: 323 amino acids; 36064 Da
Secondary accessions: F5GWR4 Q5VTS9 Q8N518
Alternative splicing: 2 isoforms:  O95847-1   O95847-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC25A27: NX_O95847

Explore proteomics data for SLC25A27 at MOPED


See SLC25A27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001190980.1  NP_001190981.1  NP_004268.3  

ENSEMBL proteins: 
 ENSP00000360398   ENSP00000474781   ENSP00000474429   ENSP00000474828   ENSP00000473804  
 ENSP00000412024   ENSP00000412223  

SLC25A27 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for SLC25A27
OriGene Protein Over-expression Lysate for SLC25A27
OriGene Custom MassSpec
OriGene Custom Protein Services for SLC25A27
GenScript Custom Purified and Recombinant Proteins Services for SLC25A27
Novus Biologicals SLC25A27 Protein
Novus Biologicals SLC25A27 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for SLC25A27 

 
antibodies-online proteins for SLC25A27 (2 products) 

 
antibodies-online peptides for SLC25A27

SLC25A27 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for SLC25A27
Novus Biologicals SLC25A27 Antibodies
Abcam antibodies for SLC25A27
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for SLC25A27
antibodies-online antibodies for SLC25A27 (13 products) 

SLC25A27 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SLC25A27
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SLC25A27
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for SLC25A27 
antibodies-online kits for SLC25A27 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Uncoupling protein 4
Mitochondrial uncoupling proteins

2 InterPro protein domains:
 IPR023395 Mt_carrier_dom
 IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry O95847

ProtoNet protein and cluster: O95847

UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847
Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
Similarity: Contains 3 Solcar repeats


Find genes that share domains with SLC25A27           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: UCP4_HUMAN, O95847
Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial
membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the
form of heat. May play a role in thermoregulatory heat production and metabolism in brain

Phenotypes:
     2 GenomeRNAi human phenotypes for SLC25A27:

 Decreased circadian period len  Increased number of cells in m 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for SLC25A27

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat SLC25A27 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC25A27 (see all 44):
hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-let-7g hsa-miR-372
SwitchGear 3'UTR luciferase reporter plasmidSLC25A27 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SLC25A27
Predesigned siRNA for gene silencing in human, mouse, rat SLC25A27

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SLC25A27

Clone
Products:
     
OriGene clones in human, mouse for SLC25A27 (see all 8)
OriGene ORF clones in mouse, rat for SLC25A27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): SLC25A27 (NM_004277)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A27
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A27

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SLC25A27
Browse ESI BIO Cell Lines and PureStem Progenitors for SLC25A27 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A27


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
UCP4_HUMAN, O95847: Mitochondrion inner membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol3
nucleus2
peroxisome1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion TAS10025957
GO:0005743mitochondrial inner membrane IEA--
GO:0016021integral component of membrane IEA--
GO:0043025neuronal cell body IEA--
GO:0045177apical part of cell IEA--

Find genes that share ontologies with SLC25A27           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for SLC25A27 About    
See pathways by source

SuperPathContained pathways About
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Electron Transport Chain0.75


1 BioSystems Pathway for SLC25A27
    Electron Transport Chain


    Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A27: 
          Mitochondria in human mouse rat

Interactions:

    GeneGlobe Interaction Network for SLC25A27

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for SLC25A27 (O958473 ENSP000003603984) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
PRKAR1AP106443I2D: score=1 
CYP3A4ENSP000003379154STRING: ENSP00000337915
CYP3A43ENSP000002223824STRING: ENSP00000222382
CYP3A5ENSP000002229824STRING: ENSP00000222982
CYP3A7ENSP000003374504STRING: ENSP00000337450
About this table

Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006091generation of precursor metabolites and energy TAS10025957
GO:0006810transport IEA--
GO:0008284positive regulation of cell proliferation IEA--
GO:0010917negative regulation of mitochondrial membrane potential IEA--
GO:0035356cellular triglyceride homeostasis IEA--

Find genes that share ontologies with SLC25A27           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC25A27 (UCP4)

2 Novoseek inferred chemical compound relationships for SLC25A27 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hydrogen 21.2 1 10736318 (1)
calcium 15.2 1 17035241 (1)



Find genes that share compounds with SLC25A27           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SLC25A27 gene (3 alternative transcripts): 
NM_001204051.1  NM_001204052.1  NM_004277.4  

Unigene Cluster for SLC25A27:

Solute carrier family 25, member 27
Hs.40510  [show with all ESTs]
Unigene Representative Sequence: NM_004277
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371347(uc011dwb.2 uc003oyh.3 uc003oyg.3 uc011dwc.2 uc003oyi.3)
ENST00000603486 ENST00000604908 ENST00000604217 ENST00000604127 ENST00000604616
ENST00000603501 ENST00000411689 ENST00000452689
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SLC25A27 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC25A27 (see all 44):
hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-let-7d hsa-miR-106a hsa-miR-449a hsa-let-7g hsa-miR-372
SwitchGear 3'UTR luciferase reporter plasmidSLC25A27 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SLC25A27
Predesigned siRNA for gene silencing in human, mouse, rat SLC25A27
Clone
Products:
     
OriGene clones in human, mouse for SLC25A27 (see all 8)
OriGene ORF clones in mouse, rat for SLC25A27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): SLC25A27 (NM_004277)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A27
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A27
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SLC25A27
OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A27
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A27
  QuantiTect SYBR Green Assays in human, mouse, rat SLC25A27
  QuantiFast Probe-based Assays in human, mouse, rat SLC25A27

Additional mRNA sequence: 

AF110532.1 AK291427.1 AK295233.1 AK302906.1 AK315940.1 AY358711.1 BC033091.1 

8 DOTS entries:

DT.100818364  DT.214109  DT.87016596  DT.100818363  DT.100020910  DT.40120289  DT.121363427  DT.75169502 

Selected AceView cDNA sequences (see all 82):

CK429468 Z42553 CD242871 AW161176 BU686290 AA857932 AI683883 BM682104 
AV654180 AW055254 CB241965 BG925533 AW511808 CA429578 AW769475 AW269206 
AI369942 BG149893 BG149894 BM047096 BP360780 BG149655 BC033091 AI569344 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A27 (see all 8)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1:                          -     -           -                                                                                       
SP2:                                                                                            -           -     -     -               
SP3:                          -     -           -                             -     -     -     -                                       
SP4:                                            -                                                                                       
SP5:                                                                          -     -     -     -                                       


ECgene alternative splicing isoforms for SLC25A27

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SLC25A27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACTGATATG
SLC25A27 Expression
About this image

SLC25A27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC25A27 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.40510

UniProtKB/Swiss-Prot: UCP4_HUMAN, O95847
Tissue specificity: Found in adult and fetal brain. Present in most of the brain tissues, with low levels in
spinal chord, corpus callosum and substantia nigra

    Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A27: 
          Mitochondria in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for SLC25A27
OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A27
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A27
QuantiTect SYBR Green Assays in human, mouse, rat SLC25A27
QuantiFast Probe-based Assays in human, mouse, rat SLC25A27
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A27

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A27 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc25a271 , 5 solute carrier family 25, member 271, 5 88.99(n)1
96.23(a)1
  17 (19.75 cM)5
740111  NM_028711.31  NP_082987.11 
 436419005 
African clawed frog
(Xenopus laevis)
Amphibia 480112652   -- 73.84(n)    48011265 
zebrafish
(Danio rerio)
Actinopterygii zgc638992 hypothetical protein MGC63899 74.41(n)   393312  BC053139.1 
fruit fly
(Drosophila melanogaster)
Insecta Ucp4A1 Ucp4A 55.78(n)
58(a)
  32764  NM_001201735.1  NP_001188664.1 
worm
(Caenorhabditis elegans)
Secernentea ucp-41 ucp-4 55.25(n)
52.4(a)
  179315  NM_073013.5  NP_505414.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G141401 AT1G14140 51.34(n)
44.3(a)
  837973  NM_101279.2  NP_172866.1 


ENSEMBL Gene Tree for SLC25A27 (if available)
TreeFam Gene Tree for SLC25A27 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for SLC25A27 gene
UCP32  UCP12  UCP22  SLC25A142  SLC25A112  ENSG000002626602  SLC25A102  SLC25A302  
11 SIMAP similar genes for SLC25A27 using alignment to 6 protein entries:     UCP4_HUMAN (see all proteins):
SLC25A22    SLC25A30    UCP1    SLC25A14    SLC25A11    SLC25A10
UCP2    SLC25A35    UCP3    SLC25A34    SLC25A1

Find genes that share paralogs with SLC25A27           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SLC25A27 (see all 435)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1459009761,2
C--46622578(+) ACTTCC/TCTTCC 3 -- int10--------
rs1814779771,2
--46622636(+) TGGTGA/GTCATT 3 -- int10--------
rs1383093861,2
--46622748(+) CCTTAG/TGTAGG 3 -- int10--------
rs779485911,2
C,F--46623028(+) ACCCAC/G/TGAAAT 3 -- int11NA 120
rs1864667591,2
--46623097(+) TTCTAA/GTGTTA 3 -- int10--------
rs775870621,2
F--46623141(+) GAGGAT/CAGCAC 3 -- int11Minor allele frequency- C:0.01NA 120
rs1908960931,2
--46623230(+) TAGAAA/GGAACC 3 -- int10--------
rs1120808051,2
C--46623272(+) TGTTTG/TTTTTT 3 -- int10--------
rs709963841,2
C--46623310(-) CTAGC-/AAAAAA/AAAAAAAA
AAAAAAAAAAAAAAAAAA
AAAAA
6 -- int1 cds11NA 2
rs1823761101,2
--46623317(+) CTAGTA/GATCCA 3 -- int10--------

HapMap Linkage Disequilibrium report for SLC25A27 (46620652 - 46645930 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for SLC25A27:    About this table    
Variant IDTypeSubtypePubMed ID
nsv885868CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC25A27
DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A27

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 613725    OMIM disorders: --


Find genes that share disorders with SLC25A27           About GenesLikeMe

Genetic Association Database (GAD): SLC25A27
Human Genome Epidemiology (HuGE) Navigator: SLC25A27 (9 documents)

Export disorders for SLC25A27 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SLC25A27 gene, integrated from 10 sources (see all 41):
(articles sorted by number of sources associating them with SLC25A27)
    Utopia: connect your pdf to the dynamic
world of online information

  1. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. (PubMed id 10025957)1, 2, 3, 9 Mao W....Pan G. (FEBS Lett. 1999)
  2. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PubMed id 17066476)1, 4, 9 Yasuno K....Tamiya G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
  3. A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis. (PubMed id 19536655)1, 4, 9 Szolnoki Z....Somogyvari F. (Neuromolecular Med. 2009)
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  5. Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM. (PubMed id 18755175)1, 4 Lee H.J....Oh B. ( international journal of clinical chemistry 2008)
  6. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
  7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
  8. Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG. (PubMed id 16378686)1, 4 Norberg A....Holmberg M. (Neurosci. Lett. 2006)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 9481 HGNC: 21065 AceView: SLC25A27 Ensembl:ENSG00000153291 euGenes: HUgn9481
ECgene: SLC25A27 H-InvDB: SLC25A27

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for SLC25A27 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for SLC25A27 gene:
Search GeneIP for patents involving SLC25A27

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC25A27  
 OriGene qPCR primer pairs and template standards for SLC25A27   OriGene Protein Over-expression Lysate for SLC25A27  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC25A27  
 OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A27   OriGene Purified Protein for SLC25A27  
 OriGene ORF clones in mouse, rat for SLC25A27   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SLC25A27   OriGene Custom Protein Services for SLC25A27  

 
 
 Block miRNA regulation of human, mouse, rat SLC25A27 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC25A27
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A27 Predesigned siRNA for gene silencing in human, mouse, rat SLC25A27
 QuantiFast Probe-based Assays in human, mouse, rat SLC25A27 QuantiTect SYBR Green Assays in human, mouse, rat SLC25A27
 PCR Arrays including human, mouse, rat SLC25A27 Search Chromatin IP Primers for SLC25A27
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A27  GeneGlobe Interaction Network for SLC25A27
 Regulatory tfbs in SLC25A27 promoter
 GenScript Custom Purified and Recombinant Proteins Services for SLC25A27 GenScript cDNA clones with any tag delivered in your preferred vector for SLC25A27
 GenScript Custom Assay Services for SLC25A27 GenScript Custom overexpressing Cell Line Services for SLC25A27
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SLC25A27 (UCP4)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 SLC25A27 antibodies
 SLC25A27 proteins
 SLC25A27 lysates
 Antibodies for SLC25A27
 See all of Abcam's Antibodies, Kits and Proteins for SLC25A27
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for SLC25A27
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A27
 SwitchGear 3'UTR luciferase reporter plasmids for SLC25A27
 SwitchGear Promoter luciferase reporter plasmids for SLC25A27
 ThermoFisher Antibodies for SLC25A27
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A27
 Browse compounds at ApexBio
 Search Addgene for plasmids for SLC25A27
  Search eBioscience for proteins for SLC25A27
  Search eBioscience for elisas for SLC25A27
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for SLC25A27
 antibodies-online antibodies for SLC25A27 (13 products)
 antibodies-online kits for SLC25A27 (2 products)
 antibodies-online peptides for SLC25A27
 antibodies-online proteins for SLC25A27 (2 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SLC25A27 gene at Home site.
Version: 3.12.258 10 Dec 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4