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Aliases for SLC25A27 Gene

Aliases for SLC25A27 Gene

  • Solute Carrier Family 25 Member 27 2 3 4 5
  • UCP 4 3 4
  • UCP4 3 4
  • Solute Carrier Family 25, Member 27 2
  • Mitochondrial Uncoupling Protein 4 3
  • Uncoupling Protein 4 3

External Ids for SLC25A27 Gene

Previous GeneCards Identifiers for SLC25A27 Gene

  • GC00U912988
  • GC06P046667
  • GC06P046728
  • GC06P046343

Summaries for SLC25A27 Gene

Entrez Gene Summary for SLC25A27 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

GeneCards Summary for SLC25A27 Gene

SLC25A27 (Solute Carrier Family 25 Member 27) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Mitochondrial Uncoupling Proteins. An important paralog of this gene is SLC25A14.

UniProtKB/Swiss-Prot for SLC25A27 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Gene Wiki entry for SLC25A27 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A27 Gene

Genomics for SLC25A27 Gene

Regulatory Elements for SLC25A27 Gene

Enhancers for SLC25A27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G046651 1 ENCODE 29 -0.4 -384 2.6 PKNOX1 ATF1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 TDRD6 SLC25A27 PLA2G7 CYP39A1 RCAN2
GH06G046733 0.9 ENCODE 15 +82.0 81989 1.8 ZSCAN4 ZNF76 KLF17 RAD21 ZNF2 ZNF121 GLIS2 ZNF302 ZNF366 EGR2 TDRD6 SLC25A27 CD2AP PLA2G7 GC06P046731
GH06G046848 1.2 Ensembl ENCODE 7.7 +196.1 196073 1.3 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 GATA2 ZNF143 SLC25A27 GC06M046858 GC06M046859 GC06P046830
GH06G046814 0.9 FANTOM5 ENCODE 7.2 +163.2 163233 2.8 MAFF ZNF316 MAFG EMSY MAFK PLA2G7 LOC101926962 SLC25A27 MEP1A ADGRF4 GC06P046830
GH06G046932 1 Ensembl ENCODE dbSUPER 5.7 +280.4 280413 2.0 GATA2 ATF2 NR2F2 ADGRF5 LOC101926962 SLC25A27 TDRD6 LOC105375080
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A27 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197591 -114 2000 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1

Genomic Location for SLC25A27 Gene

Chromosome:
6
Start:
46,652,915 bp from pter
End:
46,678,193 bp from pter
Size:
25,279 bases
Orientation:
Plus strand

Genomic View for SLC25A27 Gene

Genes around SLC25A27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A27 Gene

Proteins for SLC25A27 Gene

  • Protein details for SLC25A27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95847-UCP4_HUMAN
    Recommended name:
    Mitochondrial uncoupling protein 4
    Protein Accession:
    O95847
    Secondary Accessions:
    • F5GWR4
    • Q5VTS9
    • Q8N518

    Protein attributes for SLC25A27 Gene

    Size:
    323 amino acids
    Molecular mass:
    36064 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A27 Gene

Post-translational modifications for SLC25A27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A27 Gene

Domains & Families for SLC25A27 Gene

Gene Families for SLC25A27 Gene

Protein Domains for SLC25A27 Gene

Graphical View of Domain Structure for InterPro Entry

O95847

UniProtKB/Swiss-Prot:

UCP4_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A27: view

Function for SLC25A27 Gene

Molecular function for SLC25A27 Gene

UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Gene Ontology (GO) - Molecular Function for SLC25A27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A27: view
genes like me logo Genes that share phenotypes with SLC25A27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A27 Gene

Localization for SLC25A27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A27 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A27 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 10025957
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
GO:0031966 mitochondrial membrane IDA 10025957
genes like me logo Genes that share ontologies with SLC25A27: view

Pathways & Interactions for SLC25A27 Gene

genes like me logo Genes that share pathways with SLC25A27: view

Interacting Proteins for SLC25A27 Gene

Gene Ontology (GO) - Biological Process for SLC25A27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0009409 response to cold IBA --
GO:0010917 negative regulation of mitochondrial membrane potential IEA --
genes like me logo Genes that share ontologies with SLC25A27: view

No data available for SIGNOR curated interactions for SLC25A27 Gene

Drugs & Compounds for SLC25A27 Gene

(1) Drugs for SLC25A27 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC25A27 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A27: view

Transcripts for SLC25A27 Gene

Unigene Clusters for SLC25A27 Gene

Solute carrier family 25, member 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A27 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for SLC25A27 Gene

GeneLoc Exon Structure for
SLC25A27
ECgene alternative splicing isoforms for
SLC25A27

Expression for SLC25A27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A27 Gene

Protein differential expression in normal tissues from HIPED for SLC25A27 Gene

This gene is overexpressed in Brain (54.3) and Frontal cortex (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC25A27 Gene



Protein tissue co-expression partners for SLC25A27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A27 Gene:

SLC25A27

SOURCE GeneReport for Unigene cluster for SLC25A27 Gene:

Hs.40510

mRNA Expression by UniProt/SwissProt for SLC25A27 Gene:

O95847-UCP4_HUMAN
Tissue specificity: Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.

Evidence on tissue expression from TISSUES for SLC25A27 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SLC25A27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A27 Gene

Orthologs for SLC25A27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A27 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia SLC25A27 34 35
  • 94.63 (n)
cow
(Bos Taurus)
Mammalia SLC25A27 34 35
  • 92.16 (n)
mouse
(Mus musculus)
Mammalia Slc25a27 34 16 35
  • 88.99 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a27 34
  • 88.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A27 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a27 34
  • 71.68 (n)
Str.20468 34
zebrafish
(Danio rerio)
Actinopterygii slc25a27 34 35
  • 67.31 (n)
zgc63899 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009603 34
  • 56 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ucp4A 34 35
  • 55.78 (n)
worm
(Caenorhabditis elegans)
Secernentea ucp-4 34 35
  • 55.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G14140 34
  • 51.34 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1001 34
Species where no ortholog for SLC25A27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A27 Gene

ENSEMBL:
Gene Tree for SLC25A27 (if available)
TreeFam:
Gene Tree for SLC25A27 (if available)

Paralogs for SLC25A27 Gene

genes like me logo Genes that share paralogs with SLC25A27: view

Variants for SLC25A27 Gene

Sequence variations from dbSNP and Humsavar for SLC25A27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000136848 -- 46,670,810(+) CCCGC(A/T)CACTG intron-variant
rs1000217349 -- 46,654,846(+) CCTTC(A/C)CCACA intron-variant, upstream-variant-2KB
rs1000231260 -- 46,658,724(+) GAGAA(A/G)GGAGA intron-variant
rs1000245782 -- 46,664,587(+) TTTTT(A/C)TAAAG intron-variant
rs1000262228 -- 46,658,429(+) GCTAA(A/G)ATTCA intron-variant

Variation tolerance for SLC25A27 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC25A27 Gene

Disorders for SLC25A27 Gene

Relevant External Links for SLC25A27

Genetic Association Database (GAD)
SLC25A27
Human Genome Epidemiology (HuGE) Navigator
SLC25A27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A27

No disorders were found for SLC25A27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A27 Gene

Publications for SLC25A27 Gene

  1. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. (PMID: 10025957) Mao W. … Pan G. (FEBS Lett. 1999) 2 3 4 22 64
  2. A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis. (PMID: 19536655) Szolnoki Z. … Somogyvari F. (Neuromolecular Med. 2009) 3 22 46 64
  3. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PMID: 17066476) Yasuno K. … Tamiya G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 22 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM. (PMID: 18755175) Lee H.J. … Oh B. (Clin. Chim. Acta 2008) 3 46 64

Products for SLC25A27 Gene

Sources for SLC25A27 Gene

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