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Aliases for SLC25A27 Gene

Aliases for SLC25A27 Gene

  • Solute Carrier Family 25 Member 27 2 3 4 5
  • Solute Carrier Family 25, Member 27 2 3
  • UCP 4 3 4
  • UCP4 3 4
  • Uncoupling Protein 4 3

External Ids for SLC25A27 Gene

Previous GeneCards Identifiers for SLC25A27 Gene

  • GC00U912988
  • GC06P046667
  • GC06P046728
  • GC06P046343

Summaries for SLC25A27 Gene

Entrez Gene Summary for SLC25A27 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

GeneCards Summary for SLC25A27 Gene

SLC25A27 (Solute Carrier Family 25 Member 27) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Mitochondrial Uncoupling Proteins. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for SLC25A27 Gene

  • UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Gene Wiki entry for SLC25A27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A27 Gene

Genomics for SLC25A27 Gene

Regulatory Elements for SLC25A27 Gene

Enhancers for SLC25A27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A27 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A27 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A27 Gene

Chromosome:
6
Start:
46,652,915 bp from pter
End:
46,678,193 bp from pter
Size:
25,279 bases
Orientation:
Plus strand

Genomic View for SLC25A27 Gene

Genes around SLC25A27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A27 Gene

Proteins for SLC25A27 Gene

  • Protein details for SLC25A27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95847-UCP4_HUMAN
    Recommended name:
    Mitochondrial uncoupling protein 4
    Protein Accession:
    O95847
    Secondary Accessions:
    • F5GWR4
    • Q5VTS9
    • Q8N518

    Protein attributes for SLC25A27 Gene

    Size:
    323 amino acids
    Molecular mass:
    36064 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A27 Gene

Proteomics data for SLC25A27 Gene at MOPED

Post-translational modifications for SLC25A27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A27 Gene

No data available for DME Specific Peptides for SLC25A27 Gene

Domains & Families for SLC25A27 Gene

Gene Families for SLC25A27 Gene

Protein Domains for SLC25A27 Gene

Graphical View of Domain Structure for InterPro Entry

O95847

UniProtKB/Swiss-Prot:

UCP4_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A27: view

Function for SLC25A27 Gene

Molecular function for SLC25A27 Gene

UniProtKB/Swiss-Prot Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.
genes like me logo Genes that share phenotypes with SLC25A27: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A27 Gene

Localization for SLC25A27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A27 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A27 Gene COMPARTMENTS Subcellular localization image for SLC25A27 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A27 Gene

Pathways & Interactions for SLC25A27 Gene

genes like me logo Genes that share pathways with SLC25A27: view

Interacting Proteins for SLC25A27 Gene

Selected Interacting proteins: O95847-UCP4_HUMAN for SLC25A27 Gene via I2D

Symbol External ID(s) Details
PRKAR1A

Gene Ontology (GO) - Biological Process for SLC25A27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with SLC25A27: view

No data available for SIGNOR curated interactions for SLC25A27 Gene

Drugs & Compounds for SLC25A27 Gene

(1) Drugs for SLC25A27 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC25A27 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A27: view

Transcripts for SLC25A27 Gene

Unigene Clusters for SLC25A27 Gene

Solute carrier family 25, member 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A27 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for SLC25A27 Gene

GeneLoc Exon Structure for
SLC25A27
ECgene alternative splicing isoforms for
SLC25A27

Expression for SLC25A27 Gene

mRNA expression in normal human tissues for SLC25A27 Gene

Protein differential expression in normal tissues from HIPED for SLC25A27 Gene

This gene is overexpressed in Brain (54.3) and Frontal cortex (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC25A27 Gene



SOURCE GeneReport for Unigene cluster for SLC25A27 Gene Hs.40510

mRNA Expression by UniProt/SwissProt for SLC25A27 Gene

O95847-UCP4_HUMAN
Tissue specificity: Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.
genes like me logo Genes that share expression patterns with SLC25A27: view

Protein tissue co-expression partners for SLC25A27 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC25A27 Gene

Orthologs for SLC25A27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A27 35
  • 92.16 (n)
  • 94.74 (a)
SLC25A27 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A27 35
  • 94.63 (n)
  • 97.21 (a)
SLC25A27 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a27 35
  • 88.99 (n)
  • 96.23 (a)
Slc25a27 16
Slc25a27 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A27 35
  • 99.79 (n)
  • 99.69 (a)
SLC25A27 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a27 35
  • 88.26 (n)
  • 94.97 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A27 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a27 35
  • 71.68 (n)
  • 74.84 (a)
Str.20468 35
zebrafish
(Danio rerio)
Actinopterygii slc25a27 35
  • 67.31 (n)
  • 69.26 (a)
zgc63899 35
slc25a27 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009603 35
  • 56 (n)
  • 58.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ucp4A 35
  • 55.78 (n)
  • 58 (a)
Ucp4A 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ucp-4 35
  • 55.25 (n)
  • 52.4 (a)
ucp-4 36
  • 48 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G14140 35
  • 51.34 (n)
  • 44.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1001 35
Species with no ortholog for SLC25A27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A27 Gene

ENSEMBL:
Gene Tree for SLC25A27 (if available)
TreeFam:
Gene Tree for SLC25A27 (if available)

Paralogs for SLC25A27 Gene

genes like me logo Genes that share paralogs with SLC25A27: view

Variants for SLC25A27 Gene

Sequence variations from dbSNP and Humsavar for SLC25A27 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs35884480 - 46,664,857(+) CAATA(C/T)ACAAA nc-transcript-variant, reference, missense
rs17853162 - 46,662,426(+) TTTAG(C/T)CAATC nc-transcript-variant, reference, missense
rs5875977 -- 46,658,489(+) AATTA(-/T)TGTAT intron-variant
rs6900121 -- 46,656,342(+) caccc(A/G)gctaa intron-variant
rs6900238 -- 46,656,283(+) tcaag(C/T)gattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A27 Gene

Variant ID Type Subtype PubMed ID
nsv885868 CNV Gain 21882294

Variation tolerance for SLC25A27 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC25A27 Gene

Disorders for SLC25A27 Gene

Relevant External Links for SLC25A27

Genetic Association Database (GAD)
SLC25A27
Human Genome Epidemiology (HuGE) Navigator
SLC25A27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A27

No disorders were found for SLC25A27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A27 Gene

Publications for SLC25A27 Gene

  1. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. (PMID: 10025957) Mao W. … Pan G. (FEBS Lett. 1999) 2 3 4 23 67
  2. A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis. (PMID: 19536655) Szolnoki Z. … Somogyvari F. (Neuromolecular Med. 2009) 3 23
  3. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PMID: 17066476) Yasuno K. … Tamiya G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23
  4. Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells. (PMID: 17035241) Chan S.L. … Mattson M.P. (J. Biol. Chem. 2006) 3 23
  5. Specific sequence of motifs of mitochondrial uncoupling proteins. (PMID: 10772343) Jezek P. … UrbA!nkovA! E. (IUBMB Life 2000) 2 3

Products for SLC25A27 Gene

Sources for SLC25A27 Gene

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