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Aliases for SLC25A26 Gene

Aliases for SLC25A26 Gene

  • Solute Carrier Family 25 (S-Adenosylmethionine Carrier), Member 26 2 3
  • SAMC 3 4 6
  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 26 2 3
  • Mitochondrial S-Adenosylmethionine Transporter 3 4
  • S-Adenosylmethionine Mitochondrial Carrier Protein 3
  • Solute Carrier Family 25 Member 26 4

External Ids for SLC25A26 Gene

Summaries for SLC25A26 Gene

Entrez Gene Summary for SLC25A26 Gene

  • Mitochondrial carriers, including SLC25A26, are a family of transport proteins found mostly in the inner membranes of mitochondria. They shuttle metabolites and cofactors through the mitochondrial membrane (Agrimi et al., 2004 [PubMed 14674884]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A26 Gene

SLC25A26 (Solute Carrier Family 25 (S-Adenosylmethionine Carrier), Member 26) is a Protein Coding gene. GO annotations related to this gene include S-adenosyl-L-methionine transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC25A26 Gene

  • Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A26 Gene

Genomics for SLC25A26 Gene

Genomic Location for SLC25A26 Gene

Start:
66,133,610 bp from pter
End:
66,388,116 bp from pter
Size:
254,507 bases
Orientation:
Plus strand

Genomic View for SLC25A26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A26 Gene

No data available for Regulatory Elements for SLC25A26 Gene

Proteins for SLC25A26 Gene

  • Protein details for SLC25A26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70HW3-SAMC_HUMAN
    Recommended name:
    S-adenosylmethionine mitochondrial carrier protein
    Protein Accession:
    Q70HW3
    Secondary Accessions:
    • A8K758
    • B3KRZ7
    • Q7Z786
    • Q96E68

    Protein attributes for SLC25A26 Gene

    Size:
    274 amino acids
    Molecular mass:
    29381 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A26 Gene

Proteomics data for SLC25A26 Gene at MOPED

Post-translational modifications for SLC25A26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A26 Gene

No data available for DME Specific Peptides for SLC25A26 Gene

Domains for SLC25A26 Gene

Gene Families for SLC25A26 Gene

Protein Domains for SLC25A26 Gene

UniProtKB/Swiss-Prot:

SAMC_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q70HW3
Similarity:
  • Contains 3 Solcar repeats.:
    • Q70HW3
genes like me logo Genes that share domains with SLC25A26: view

Function for SLC25A26 Gene

Molecular function for SLC25A26 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Strongly inhibited by tannic acid and Bromocresol Purple.
UniProtKB/Swiss-Prot Function: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.

Gene Ontology (GO) - Molecular Function for SLC25A26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity IMP 14674884
genes like me logo Genes that share ontologies with SLC25A26: view

Phenotypes for SLC25A26 Gene

genes like me logo Genes that share phenotypes with SLC25A26: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC25A26 Gene

Localization for SLC25A26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A26 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A26 Gene COMPARTMENTS Subcellular localization image for SLC25A26 gene
Compartment Confidence
mitochondrion 5
nucleus 4
extracellular 3
endoplasmic reticulum 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC25A26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IDA 14674884
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A26: view

Pathways for SLC25A26 Gene

SuperPathways for SLC25A26 Gene

No Data Available

Interacting Proteins for SLC25A26 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000336801%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000367207%0d%0a9606.ENSP00000262211%0d%0a9606.ENSP00000270202%0d%0a
Selected Interacting proteins: ENSP00000336801 Q70HW3-SAMC_HUMAN for SLC25A26 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC25A26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0015805 S-adenosyl-L-methionine transport IMP 14674884
GO:1901962 S-adenosyl-L-methionine transmembrane transport IMP 14674884
genes like me logo Genes that share ontologies with SLC25A26: view

No data available for Pathways by source for SLC25A26 Gene

Compounds for SLC25A26 Gene

(1) HMDB Compounds for SLC25A26 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with SLC25A26: view

Transcripts for SLC25A26 Gene

Unigene Clusters for SLC25A26 Gene

Solute carrier family 25 (S-adenosylmethionine carrier), member 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A26 Gene

No ASD Table

Relevant External Links for SLC25A26 Gene

GeneLoc Exon Structure for
SLC25A26
ECgene alternative splicing isoforms for
SLC25A26

Expression for SLC25A26 Gene

mRNA expression in normal human tissues for SLC25A26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC25A26 Gene

SOURCE GeneReport for Unigene cluster for SLC25A26 Gene Hs.379386

mRNA Expression by UniProt/SwissProt for SLC25A26 Gene

Q70HW3-SAMC_HUMAN
Tissue specificity: Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen.
genes like me logo Genes that share expressions with SLC25A26: view

Orthologs for SLC25A26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A26 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A26 36
  • 88.93 (n)
  • 87.59 (a)
SLC25A26 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A26 36
  • 91.85 (n)
  • 91.24 (a)
SLC25A26 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a26 36
  • 84.43 (n)
  • 87.59 (a)
Slc25a26 16
Slc25a26 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A26 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A26 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a26 36
  • 79.75 (n)
  • 79.44 (a)
chicken
(Gallus gallus)
Aves SLC25A26 36
  • 79.62 (n)
  • 83.08 (a)
SLC25A26 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A26 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6675 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a26 36
  • 68.41 (n)
  • 76.4 (a)
Str.3522 36
zebrafish
(Danio rerio)
Actinopterygii slc25a26 36
  • 65.79 (n)
  • 69.29 (a)
slc25a26 37
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003536 36
  • 51.72 (n)
  • 49.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4743 36
  • 50.88 (n)
  • 51.5 (a)
CG4743 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_D1046.3 36
  • 51.96 (n)
  • 48.99 (a)
D1046.3 37
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL014C 36
  • 49.22 (n)
  • 47.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PET8 36
  • 51.95 (n)
  • 48.83 (a)
PET8 37
  • 44 (a)
OneToOne
PET8 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04950g 36
  • 51.09 (n)
  • 45.59 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SAMC1 36
  • 45.96 (n)
  • 38.28 (a)
rice
(Oryza sativa)
Liliopsida Os07g0295000 36
  • 47.79 (n)
  • 38.67 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01568 36
  • 51 (n)
  • 53.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC12B10.09 36
  • 50.8 (n)
  • 46.4 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2574 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToOne
Species with no ortholog for SLC25A26:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A26 Gene

ENSEMBL:
Gene Tree for SLC25A26 (if available)
TreeFam:
Gene Tree for SLC25A26 (if available)

Paralogs for SLC25A26 Gene

No data available for Paralogs for SLC25A26 Gene

Variants for SLC25A26 Gene

Sequence variations from dbSNP and Humsavar for SLC25A26 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs332345 -- 66,273,106(+) atttg(C/T)gtata intron-variant
rs332344 -- 66,273,015(+) tgaat(C/G)ttgtc intron-variant
rs332343 -- 66,272,961(+) agata(A/T)gtccc intron-variant
rs332342 -- 66,272,241(+) GCCCA(A/G)GGTCT intron-variant
rs332341 -- 66,269,656(+) AACTT(C/T)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A26 Gene

Variant ID Type Subtype PubMed ID
nsv876911 CNV Loss 21882294
nsv528820 CNV Loss 19592680
esv2605299 CNV Insertion 19546169
esv2725368 CNV Deletion 23290073
nsv516847 CNV Loss 19592680

Relevant External Links for SLC25A26 Gene

HapMap Linkage Disequilibrium report
SLC25A26

Disorders for SLC25A26 Gene

Relevant External Links for SLC25A26

Genetic Association Database (GAD)
SLC25A26
Human Genome Epidemiology (HuGE) Navigator
SLC25A26
genes like me logo Genes that share disorders with SLC25A26: view

No data available for UniProtKB/Swiss-Prot for SLC25A26 Gene

Publications for SLC25A26 Gene

  1. Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. (PMID: 14674884) Agrimi G. … Palmieri F. (Biochem. J. 2004) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PMID: 21076409) Sotoodehnia N. … Arking D.E. (Nat. Genet. 2010) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for SLC25A26 Gene

Sources for SLC25A26 Gene

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