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SLC25A26 Gene

protein-coding   GIFtS: 51
GCID: GC03P066120

Solute Carrier Family 25 (S-Adenosylmethionine Carrier),...

(Previous names: solute carrier family 25 (mitochondrial carrier; phosphate...)
  See related diseases
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Aliases
for SLC25A26 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25 (S-Adenosylmethionine Carrier), Member 261 2     S-Adenosylmethionine Mitochondrial Carrier Protein2
SAMC2 3 5     Solute Carrier Family 25, Member 262
Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier),
Member 261 2
     Solute Carrier Family 25 Member 263
Mitochondrial S-Adenosylmethionine Transporter2 3     

External Ids:    HGNC: 206611   Entrez Gene: 1152862   Ensembl: ENSG000001447417   OMIM: 6110375   UniProtKB: Q70HW33   

Export aliases for SLC25A26 gene to outside databases

Previous GC identifers: GC03P066226 GC03P066376


Summaries
for SLC25A26 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A26 Gene:
Mitochondrial carriers, including SLC25A26, are a family of transport proteins found mostly in the inner membranes
of mitochondria. They shuttle metabolites and cofactors through the mitochondrial membrane (Agrimi et al., 2004
(PubMed 14674884)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC25A26 Gene:
SLC25A26 (solute carrier family 25 (S-adenosylmethionine carrier), member 26) is a protein-coding gene. Diseases associated with SLC25A26 include tonsillitis, and thyroiditis. GO annotations related to this gene include S-adenosyl-L-methionine transmembrane transporter activity.

UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3
Function: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial
inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria




Genomic Views
for SLC25A26 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC25A26
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLC25A26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14.2

SLC25A26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A26 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P066120:  view genomic region     (about GC identifiers)

Start:
 66,119,285 bp from pter      End:
 66,438,540 bp from pter
Size:
 319,256 bases      Orientation:
 plus strand

1 alternative location:
Chr3+,NW_003315912 2,820-59,169     

Proteins
for SLC25A26 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3 (See protein sequence)
Recommended Name: S-adenosylmethionine mitochondrial carrier protein  
Size: 274 amino acids; 29381 Da
Secondary accessions: A8K758 B3KRZ7 Q7Z786 Q96E68
Alternative splicing: 3 isoforms:  Q70HW3-1   Q70HW3-2   Q70HW3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC25A26: NX_Q70HW3

Explore proteomics data for SLC25A26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See SLC25A26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158268.1  NP_775742.4  

    ENSEMBL proteins: 
     ENSP00000346955   ENSP00000336801   ENSP00000432574   ENSP00000415304   ENSP00000437217  
     ENSP00000442353  

    SLC25A26 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC25A26
    GenScript Custom Purified and Recombinant Proteins Services for SLC25A26
    Novus Biologicals SLC25A26 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC25A26

    SLC25A26 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC25A26
    Novus Biologicals SLC25A26 Antibody
    Abcam antibodies for SLC25A26
    Cloud-Clone Corp. Antibodies for SLC25A26
    Search ThermoFisher Antibodies for SLC25A26
    LSBio Antibodies in human, mouse, rat for SLC25A26

    SLC25A26 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SLC25A26
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    Cloud-Clone Corp. ELISAs for SLC25A26
    Cloud-Clone Corp. CLIAs for SLC25A26

    Domains /
    Families
    for SLC25A26 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: S-Adenosylmethionine carrier
    Mitochondrial nucleotide transporters

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q70HW3

    ProtoNet protein and cluster: Q70HW3

    UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A26 for domains           About GeneDecksing


    Function
    for SLC25A26 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAMC_HUMAN, Q70HW3
    Function: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial
    inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria
    Enzyme regulation: Strongly inhibited by tannic acid and Bromocresol Purple

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000095S-adenosyl-L-methionine transmembrane transporter activity IMP14674884
         
    SLC25A26 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC25A26:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc25a26):
     embryogenesis  growth/size/body  mortality/aging 

    SLC25A26 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A26
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC25A26

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC25A26
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC25A26

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat SLC25A26 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC25A26 (see all 22):
    hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-1263 hsa-miR-3616-5p hsa-miR-501-3p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: SLC25A26 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SLC25A26
    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A26

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC25A26

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SLC25A26 (NM_173471)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A26
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    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC25A26 
    In Situ Assay
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    Localization
    for SLC25A26 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAMC_HUMAN, Q70HW3: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    extracellular3
    endoplasmic reticulum1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IDA14674884
    GO:0016021integral component of membrane IEA--

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    Pathways & Interactions
    for SLC25A26 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC25A26
    Interactions:

        Search GeneGlobe Interaction Network for SLC25A26

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SLC25A26 (Q70HW33 ENSP000003368014) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPRE1Q156913, ENSP000003647214I2D: score=1 STRING: ENSP00000364721
    ACOX1Q150673I2D: score=1 
    AGPAT4Q9NRZ53I2D: score=1 
    ALDH5A1P516493I2D: score=1 
    ALLCQ8N6M53I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0015805S-adenosyl-L-methionine transport IMP14674884
    GO:1901962S-adenosyl-L-methionine transmembrane transport IMP14674884

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    Drugs & Compounds
    for SLC25A26 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC25A26 (SAMC)

    1 HMDB Compound for SLC25A26    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    Transcripts
    for SLC25A26 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC25A26 gene (3 alternative transcripts): 
    NM_001009938.1  NM_001164796.1  NM_173471.3  

    Unigene Cluster for SLC25A26:

    Solute carrier family 25 (S-adenosylmethionine carrier), member 26
    Hs.379386  [show with all ESTs]
    Unigene Representative Sequence: NM_173471
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354883(uc011bfq.2 uc011bfs.2) ENST00000336733 ENST00000464350
    ENST00000413054 ENST00000483224 ENST00000484768 ENST00000536651(uc011bft.2)

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat SLC25A26 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC25A26 (see all 22):
    hsa-miR-579 hsa-miR-495 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-1263 hsa-miR-3616-5p hsa-miR-501-3p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmid: SLC25A26 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for SLC25A26
    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A26
    Clone
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    OriGene ORF clones in mouse, rat for SLC25A26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC25A26 (NM_173471)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A26
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A26
      QuantiTect SYBR Green Assays in human, mouse, rat SLC25A26
      QuantiFast Probe-based Assays in human, mouse, rat SLC25A26

    Additional mRNA sequence: 

    AJ580932.1 AK092495.1 AK096876.1 AK291873.1 BC003399.1 BC012852.1 NR_028475.1 

    10 DOTS entries:

    DT.100657532  DT.95277669  DT.445915  DT.100036224  DT.95277670  DT.100036223  DT.120856471  DT.100826715 
    DT.100826722  DT.97814941 

    Selected AceView cDNA sequences (see all 156):

    CR592739 CR616539 CR601150 AA456540 CR621283 BM681156 BM724637 H15745 
    BM975541 AW327633 AI492926 AL522537 BX385947 AA234030 AI478736 BM988584 
    AI186375 AI140987 CR619193 CR620013 CR606146 AA719344 AI263396 CA439392 

    GeneLoc Exon Structure


    Expression
    for SLC25A26 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC25A26 expression in normal human tissues (normalized intensities)      SLC25A26 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATTGTGC
    SLC25A26 Expression
    About this image


    SLC25A26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    SLC25A26 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SLC25A26 Protein Expression

    Genevestigator expression for SLC25A26

    SOURCE GeneReport for Unigene cluster: Hs.379386

    UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3
    Tissue specificity: Widely expressed. Highly expressed in testis, with moderate expression in brain, heart,
    kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen

        Custom PCR Arrays for SLC25A26
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A26

    Orthologs
    for SLC25A26 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A26 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Slc25a261 , 5 solute carrier family 25 (mitochondrial carrier, phosphate more1, 5 84.43(n)1
    87.59(a)1    		   6 (43.13 cM)5
    675821  NM_026255.51  NP_080531.21 
     945003145 
    chicken
    (Gallus gallus)    		 Aves SLC25A261 solute carrier family 25 (S-adenosylmethionine carrier), more 79.62(n)
    83.08(a)    		   416084  NM_001277843.1  NP_001264772.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC25A266
    		 solute carrier family 25 (S-adenosylmethionine car...
    		 79(a)
    		 1 ↔ 1
    		 2(184563906-184717200)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.66752 Xenopus laevis transcribed sequence with weak similarity more 74.81(n)    CD255397.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570584862   -- 74.34(n)    57058486 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG47431 CG4743 50.88(n)
    51.5(a)    		   43101  NM_143158.2  NP_651415.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_D1046.31 CELE_D1046.3 51.96(n)
    48.99(a)    		   177711  NM_069151.4  NP_501552.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PET8(YNL003C)4
    PET81    		 S-adenosylmethionine transporter of the mitochondrial more4
    PET81    		 51.95(n)1
    48.83(a)1    		   14(625829-624975)4
    8557291, 4  NP_014395.31  NP_014395.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SAMC11 SAMC1 45.96(n)
    38.28(a)    		   830101  NM_120106.2  NP_568060.1 
    rice
    (Oryza sativa)    		 Liliopsida Os07g02950001 Os07g0295000 47.79(n)
    38.67(a)    		   4342959  NM_001065940.1  NP_001059405.1 


    ENSEMBL Gene Tree for SLC25A26 (if available)
    TreeFam Gene Tree for SLC25A26 (if available)

    Paralogs
    for SLC25A26 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Genomic Variants
    for SLC25A26 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC25A26 (see all 3755)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1452581641,2
    		--66270399(+) ATTCTG/TCGTAT 2 -- us2k10--------
    rs1472636711,2
    		--66270400(+) TTCTGC/TGTATC 2 -- us2k10--------
    rs361704061,2
    		C,F--66270447(+) AATTAT/AAAGAA 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs361912911,2
    		C--66270544(+) TGATGA/GGGGCA 2 -- us2k10--------
    rs1512606341,2
    		C--66270570(+) GTGCTG/TGCTCT 2 -- us2k10--------
    rs1912887081,2
    		--66270592(+) TGTAGC/TCACAT 2 -- us2k10--------
    rs1827947761,2
    		--66270660(+) GCTGAC/TATCAT 2 -- us2k10--------
    rs1870784971,2
    		--66270701(+) GTCTGG/TCAATC 2 -- us2k10--------
    rs361624831,2
    		C--66270951(+) ACTCCC/GGTCAG 2 -- us2k10--------
    rs361378291,2
    		C--66270961(+) GGAAAC/TTTCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC25A26 (66119285 - 66369285 bp, first 250kb of SLC25A26)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC25A26:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725368CNV Deletion23290073
    esv2605299CNV Insertion19546169
    nsv516847CNV Loss19592680
    nsv528820CNV Loss19592680
    nsv876911CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SLC25A26
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    Disorders / Diseases
    for SLC25A26 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 611037    OMIM disorders: --

    4 diseases for SLC25A26:    About MalaCards
    tonsillitis    thyroiditis    cerebritis    prostatitis


    SLC25A26 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC25A26
    Human Genome Epidemiology (HuGE) Navigator: SLC25A26 (1 document)

    Export disorders for SLC25A26 gene to outside databases

    Publications
    for SLC25A26 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for SLC25A26 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SLC25A26)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. (PubMed id 14674884)1, 2, 3, 9 Agrimi G....Palmieri F. (Biochem. J. 2004)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (Mol. Aspects Med. 2013)
    5. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PubMed id 21076409)1 Sotoodehnia N....Arking D.E. (Nat. Genet. 2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1 Muzny D.M....Gibbs R.A. (Nature 2006)

    External Searches for SLC25A26 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC25A26 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 115286 HGNC: 20661 AceView: SLC25A26 Ensembl:ENSG00000144741 euGenes: HUgn115286
    ECgene: SLC25A26 H-InvDB: SLC25A26

    Other Databases showing SLC25A26 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing SLC25A26 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC25A26 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC25A26 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SLC25A26 gene:
    Search GeneIP for patents involving SLC25A26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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