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SLC25A26 Gene(Protein Coding)

Solute Carrier Family 25 Member 26

GCID:
GC03P066120
GIFtS:
50
Genes Participants
UDN Logo

Aliases for SLC25A26 Gene

Aliases for SLC25A26 Gene

  • Solute Carrier Family 25 Member 26 2 3 4
  • Solute Carrier Family 25 (S-Adenosylmethionine Carrier), Member 26 2 3 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 26 2 3
  • Mitochondrial S-Adenosylmethionine Transporter 3 4
  • SAMC 3 4
  • COXPD28 3

External Ids for SLC25A26 Gene

Previous GeneCards Identifiers for SLC25A26 Gene

  • GC03P066226
  • GC03P066376

Summaries for SLC25A26 Gene

Entrez Gene Summary for SLC25A26 Gene

  • Mitochondrial carriers, including SLC25A26, are a family of transport proteins found mostly in the inner membranes of mitochondria. They shuttle metabolites and cofactors through the mitochondrial membrane (Agrimi et al., 2004 [PubMed 14674884]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC25A26 Gene

SLC25A26 (Solute Carrier Family 25 Member 26) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include S-adenosyl-L-methionine transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC25A26 Gene

  • Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A26 Gene

Genomics for SLC25A26 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SLC25A26 Gene

Enhancers for SLC25A26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A26 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A26 Gene

Chromosome:
3
Start:
66,133,610 bp from pter
End:
66,388,116 bp from pter
Size:
254,507 bases
Orientation:
Plus strand

Genomic View for SLC25A26 Gene

Genes around SLC25A26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A26 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLC25A26 Gene

Proteins for SLC25A26 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SLC25A26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70HW3-SAMC_HUMAN
    Recommended name:
    S-adenosylmethionine mitochondrial carrier protein
    Protein Accession:
    Q70HW3
    Secondary Accessions:
    • A8K758
    • B3KRZ7
    • Q7Z786
    • Q96E68

    Protein attributes for SLC25A26 Gene

    Size:
    274 amino acids
    Molecular mass:
    29381 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A26 Gene

Proteomics data for SLC25A26 Gene at MOPED

Protein Expression for SLC25A26 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SLC25A26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A26 Gene

Domains & Families for SLC25A26 Gene

Gene Families for SLC25A26 Gene

HGNC:
IUPHAR :

Protein Domains for SLC25A26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC25A26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70HW3

UniProtKB/Swiss-Prot:

SAMC_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A26: view

Function for SLC25A26 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SLC25A26 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by tannic acid and Bromocresol Purple.
UniProtKB/Swiss-Prot Function:
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.

Phenotypes for SLC25A26 Gene

MGI mutant phenotypes for SLC25A26:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLC25A26:
genes like me logo Genes that share phenotypes with SLC25A26: view

Animal Model Products

CRISPR Products

miRNA for SLC25A26 Gene

miRTarBase miRNAs that target SLC25A26

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A26 Gene

Localization for SLC25A26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A26 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A26 Gene COMPARTMENTS Subcellular localization image for SLC25A26 gene
Compartment Confidence
mitochondrion 5
extracellular 3
cytosol 1
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC25A26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IDA,TAS --
genes like me logo Genes that share ontologies with SLC25A26: view

Pathways & Interactions for SLC25A26 Gene

genes like me logo Genes that share pathways with SLC25A26: view

Interacting Proteins for SLC25A26 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000336801%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000367207%0d%0a9606.ENSP00000262211%0d%0a9606.ENSP00000270202%0d%0a
Selected Interacting proteins: ENSP00000336801 Q70HW3-SAMC_HUMAN for SLC25A26 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC25A26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0006811 ion transport TAS --
GO:1901962 S-adenosyl-L-methionine transmembrane transport IMP 14674884
genes like me logo Genes that share ontologies with SLC25A26: view

No data available for SIGNOR curated interactions for SLC25A26 Gene

Drugs & Compounds for SLC25A26 Gene

Products:

  1. Drug

(1) Drugs for SLC25A26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with SLC25A26: view

Transcripts for SLC25A26 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SLC25A26 Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(156) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC25A26 Gene

Solute carrier family 25 (S-adenosylmethionine carrier), member 26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A26 Gene

No ASD Table

Relevant External Links for SLC25A26 Gene

GeneLoc Exon Structure for
SLC25A26
ECgene alternative splicing isoforms for
SLC25A26

Expression for SLC25A26 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SLC25A26 Gene

mRNA expression in normal human tissues for SLC25A26 Gene
mRNA expression by BioGPS for SLC25A26 GenemRNA expression by GTEx for SLC25A26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A26 Gene

This gene is overexpressed in Liver, secretome (47.5) and Frontal cortex (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A26 Gene



SOURCE GeneReport for Unigene cluster for SLC25A26 Gene Hs.379386

mRNA Expression by UniProt/SwissProt for SLC25A26 Gene

Q70HW3-SAMC_HUMAN
Tissue specificity: Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen.
genes like me logo Genes that share expression patterns with SLC25A26: view

Protein tissue co-expression partners for SLC25A26 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for SLC25A26 Gene

Orthologs for SLC25A26 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SLC25A26 35
  • 88.93 (n)
  • 87.59 (a)
SLC25A26 36
  • 88 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SLC25A26 35
  • 91.85 (n)
  • 91.24 (a)
SLC25A26 36
  • 91 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Slc25a26 35
  • 84.43 (n)
  • 87.59 (a)
Slc25a26 16
Slc25a26 36
  • 88 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Slc25a26 35
  • 79.75 (n)
  • 79.44 (a)
oppossum
(Monodelphis domestica)
 Mammalia SLC25A26 36
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia SLC25A26 36
  • 78 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SLC25A26 36
  • 98 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SLC25A26 35
  • 79.62 (n)
  • 83.08 (a)
SLC25A26 36
  • 81 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SLC25A26 36
  • 79 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia slc25a26 35
  • 68.41 (n)
  • 76.4 (a)
Str.3522 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.6675 35
zebrafish
(Danio rerio)
 Actinopterygii slc25a26 35
  • 65.79 (n)
  • 69.29 (a)
slc25a26 36
  • 69 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003536 35
  • 51.72 (n)
  • 49.81 (a)
fruit fly
(Drosophila melanogaster)
 Insecta CG4743 35
  • 50.88 (n)
  • 51.5 (a)
CG4743 36
  • 46 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea CELE_D1046.3 35
  • 51.96 (n)
  • 48.99 (a)
D1046.3 36
  • 46 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AAL014C 35
  • 49.22 (n)
  • 47.66 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D04950g 35
  • 51.09 (n)
  • 45.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PET8 35
  • 51.95 (n)
  • 48.83 (a)
PET8 36
  • 44 (a)
 OneToOne
PET8 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons SAMC1 35
  • 45.96 (n)
  • 38.28 (a)
rice
(Oryza sativa)
 Liliopsida Os07g0295000 35
  • 47.79 (n)
  • 38.67 (a)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.2574 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU01568 35
  • 51 (n)
  • 53.78 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC12B10.09 35
  • 50.8 (n)
  • 46.4 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 53 (a)
 OneToOne
Species with no ortholog for SLC25A26:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A26 Gene

ENSEMBL:
Gene Tree for SLC25A26 (if available)
TreeFam:
Gene Tree for SLC25A26 (if available)

Paralogs for SLC25A26 Gene

No data available for Paralogs for SLC25A26 Gene

Variants for SLC25A26 Gene

Sequence variations from dbSNP and Humsavar for SLC25A26 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13874 - 66,369,532(-) CCAGC(A/C/G)TAATT nc-transcript-variant, reference, missense
rs332338 -- 66,352,995(+) ATTTA(C/G/T)GACAT intron-variant
rs332339 -- 66,352,931(+) TTTCC(G/T)TACTG intron-variant
rs332340 -- 66,268,033(+) ACTCT(A/C)TCCTA intron-variant
rs332341 -- 66,269,656(+) AACTT(C/T)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A26 Gene

Variant ID Type Subtype PubMed ID
nsv876911 CNV Loss 21882294
nsv528820 CNV Loss 19592680
esv2605299 CNV Insertion 19546169
esv2725368 CNV Deletion 23290073
nsv516847 CNV Loss 19592680

Variation tolerance for SLC25A26 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.84; 89.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A26 Gene

Human Gene Mutation Database (HGMD)
SLC25A26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A26 Gene

Disorders for SLC25A26 Gene

Relevant External Links for SLC25A26

Genetic Association Database (GAD)
SLC25A26
Human Genome Epidemiology (HuGE) Navigator
SLC25A26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A26

No disorders were found for SLC25A26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A26 Gene

Publications for SLC25A26 Gene

  1. Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. (PMID: 14674884) Agrimi G. … Palmieri F. (Biochem. J. 2004) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26. (PMID: 26522469) Kishita Y. … Wedell A. (Am. J. Hum. Genet. 2015) 3
  4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  5. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PMID: 22623531) Toyoshima M. … Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for SLC25A26 Gene

Sources for SLC25A26 Gene

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