SLC25A26 Gene
protein-coding GIFtS: 48
GCID: GC03P066120
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solute carrier family 25 (S-adenosylmethionine carrier),...(Previous names: solute carrier family 25 (mitochondrial carrier; phosphate...)
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Aliases
for SLC25A26 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 25 (S-Adenosylmethionine Carrier), Member 261 2 | | S-Adenosylmethionine Mitochondrial Carrier Protein2 | | SAMC2 3 5 | | Solute Carrier Family 25, Member 262 | | Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 261 2 | | Solute Carrier Family 25 Member 263 | | Mitochondrial S-Adenosylmethionine Transporter2 3 | | |
Export aliases for SLC25A26 gene to outside databasesPrevious GC identifers: GC03P066226 GC03P066376 |
Summaries
for SLC25A26 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC25A26:
Mitochondrial carriers, including SLC25A26, are a family of transport proteins found mostly in the inner membranes ofmitochondria. They shuttle metabolites and cofactors through the mitochondrial membrane (Agrimi et al., 2004 (PubMed14674884)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3Function: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial innermembrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria
|
Genomic Views
for SLC25A26 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022459.15 NT_022517.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SLC25A26
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC25A26
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A26 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p14.1 Ensembl cytogenetic band: 3p14.1 HGNC cytogenetic band: 3p14.2SLC25A26 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P066120: view genomic region
(about GC identifiers)
Start:
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66,119,285 bp from pter |
End:
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66,438,530 bp from pter |
Size:
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319,246 bases |
Orientation:
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plus strand |
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Proteins
for SLC25A26 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3 (See
protein sequence)Recommended Name: S-adenosylmethionine mitochondrial carrier protein Size: 274 amino acids; 29381 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: A8K758 B3KRZ7 Q7Z786 Q96E68Alternative splicing: 3 isoforms: Q70HW3-1 Q70HW3-2 Q70HW3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC25A26: NX_Q70HW3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q70HW3
SLC25A26 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001158268.1 NP_775742.4
ENSEMBL proteins: ENSP00000346955 ENSP00000415304 ENSP00000437217 ENSP00000432574 ENSP00000442353 ENSP00000336801
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SLC25A26 for ontologies About GeneDecksing
SLC25A26 Antibody Products:
Assay Products for SLC25A26: |
Protein
Domains /
Families
for SLC25A26 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC25A26 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q70HW3ProtoNet protein and cluster: Q70HW3 UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) familySimilarity: Contains 3 Solcar repeats |
Function
for SLC25A26 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3Function: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial innermembrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondriaEnzyme regulation: Strongly inhibited by tannic acid and Bromocresol Purple
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A26 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A26 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000095 | S-adenosyl-L-methionine transmembrane transporter activity |
IMP | 14674884 |
SLC25A26 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SLC25A26:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Slc25a26):
SLC25A26 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC25A26 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A26
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/47 Interacting proteins for SLC25A26 (Q70HW33 ENSP000003368014) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SLC25A26 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC25A26 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC25A26
1 HMDB Compound for SLC25A26 About this table
Search CenterWatch for drugs/clinical trials and news about SLC25A26 / SAMC
|
Transcripts
for SLC25A26 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC25A26 gene (3 alternative transcripts): NM_001009938.1 NM_001164796.1 NM_173471.3 Unigene Cluster for SLC25A26: Solute carrier family 25 (S-adenosylmethionine carrier), member 26 Hs.379386 [show with all ESTs]Unigene Representative Sequence: NM_1734717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000354883(uc011bfq.2 uc011bfs.2) ENST00000413054 ENST00000483224
ENST00000464350 ENST00000484768 ENST00000536651(uc011bft.2) ENST00000336733
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A26 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC25A26 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC25A26 (NM_173471) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC25A26 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A26 |
Additional cDNA sequence: AJ580932.1 AK092495.1 AK096876.1 AK291873.1 BC003399.1 BC012852.1 NR_028475.1 10 DOTS entries: DT.100657532 DT.95277669 DT.445915 DT.100036224 DT.95277670 DT.100036223 DT.120856471 DT.100826715 DT.100826722 DT.97814941 24/156 AceView cDNA sequences (see all 156): CR606146 AI478736 BM681156 AA456540 CR592739 CR616539 CR601150 AI492926 CR620013 AW327633 BM724637 AA234030 AL522537 BM988584 H15745 CR619193 AI140987 BM975541 BX385947 CR621283 AI186375 AI263396 AA719344 BX385946
GeneLoc Exon Structure
|
Expression
for SLC25A26 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC25A26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGATTGTGC
About this image
See SLC25A26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC25A26
SOURCE GeneReport for Unigene cluster: Hs.379386
UniProtKB/Swiss-Prot: SAMC_HUMAN, Q70HW3Tissue specificity: Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney,lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen
SABiosciences Custom PCR Arrays for SLC25A26
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC25A26
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC25A26 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A26 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A26 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A26 |
Orthologs
for SLC25A26 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC25A26 gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for SLC25A26 (if available)
TreeFam Gene Tree for SLC25A26 (if available) |
Paralogs
for SLC25A26 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SLC25A26 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC25A26 (66119285 - 66369285 bp, first 250kb of SLC25A26)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC25A26
1 Indel: 98336 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SLC25A26 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC25A26 for disorders About GeneDecksing
OMIM gene information: 611037
OMIM disorders: --
1  disease for SLC25A26: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: SLC25A26 (1 document)
Export disorders for SLC25A26 gene to outside databases
|
Publications
for SLC25A26 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC25A26 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SLC25A26) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. (PubMed id 14674884)1, 2, 3, 9 Agrimi G....Palmieri F. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Common variants in 22 loci are associated with QRS du ration and cardiac ventricular conduction. (PubMed id 21076409)1 Sotoodehnia N....Arking D.E. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1 Muzny D.M....Gibbs R.A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for SLC25A26 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC25A26 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC25A26 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC25A26 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC25A26 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC25A26 gene:
Search GeneIP for patents involving SLC25A26
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC25A26 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SLC25A26 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A26 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC25A26 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A26 |
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