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Aliases for SLC25A25 Gene

Aliases for SLC25A25 Gene

  • Solute Carrier Family 25 Member 25 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 25 2 3
  • Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 3 3 4
  • Mitochondrial ATP-Mg/Pi Carrier Protein 3 3 4
  • Calcium-Binding Mitochondrial Carrier Protein SCaMC-2 3
  • Small Calcium-Binding Mitochondrial Carrier Protein 2 4
  • Short Calcium-Binding Mitochondrial Carrier 2 3
  • Small Calcium-Binding Mitochondrial Carrier 2 3
  • KIAA1896 4
  • SCAMC-2 3
  • SCAMC2 4
  • PCSCL 3
  • MCSC3 4
  • APC3 4
  • MCSC 3

External Ids for SLC25A25 Gene

Previous GeneCards Identifiers for SLC25A25 Gene

  • GC09P126209
  • GC09P127933
  • GC09P129870
  • GC09P130831
  • GC09P100445

Summaries for SLC25A25 Gene

Entrez Gene Summary for SLC25A25 Gene

  • The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for SLC25A25 Gene

SLC25A25 (Solute Carrier Family 25 Member 25) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SLC25A23.

UniProtKB/Swiss-Prot for SLC25A25 Gene

  • Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A25 Gene

Genomics for SLC25A25 Gene

Regulatory Elements for SLC25A25 Gene

Enhancers for SLC25A25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G127962 2 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -94.9 -94853 22.2 CREB3L1 FEZF1 DMAP1 YY1 ZNF263 SP3 NFYC TBX21 PPARGC1A MEF2D PIP5KL1 DPM2 SPOUT1 LOC101929270 ENSG00000227218 SLC25A25 NAIF1 ENSG00000230848 ODF2-AS1 CDK9
GH09G128000 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -66.2 -66249 2.7 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF766 CBX5 FOS JUNB PIP5KL1 FAM102A DPM2 ENSG00000227218 ENSG00000230848 SLC25A25 NAIF1 LOC101929270 SPOUT1 FAM129B
GH09G128097 1.6 Ensembl ENCODE dbSUPER 11.9 +32.7 32674 9.0 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NAIF1 PTGES2 CIZ1 PTGES2-AS1 SLC25A25-AS1 SLC25A25 LCN2 C9orf16 DNM1 ENSG00000230536
GH09G128090 1.3 ENCODE dbSUPER 12.4 +25.0 25038 5.3 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A YY1 TCF12 GATA2 ELK1 SLC25A25-AS1 PTGES2 PTGES2-AS1 NAIF1 SLC25A25 ENSG00000230848 LCN2 C9orf16 CIZ1 ENSG00000230536
GH09G127959 1.2 Ensembl ENCODE dbSUPER 11.6 -107.4 -107362 2.0 BCOR ESRRA ZMYM3 ZIC2 ZKSCAN1 ZNF664 ZNF316 NR2F6 SMARCA5 NFIA PIP5KL1 FAM102A ENSG00000230848 SLC25A25 NAIF1 LCN2 C9orf16 CIZ1 DPM2 GC09P127942
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A25 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241807 100 2601 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A ZBTB7B YY1

Genomic Location for SLC25A25 Gene

Chromosome:
9
Start:
128,068,200 bp from pter
End:
128,109,258 bp from pter
Size:
41,059 bases
Orientation:
Plus strand

Genomic View for SLC25A25 Gene

Genes around SLC25A25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A25 Gene

Proteins for SLC25A25 Gene

  • Protein details for SLC25A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6KCM7-SCMC2_HUMAN
    Recommended name:
    Calcium-binding mitochondrial carrier protein SCaMC-2
    Protein Accession:
    Q6KCM7
    Secondary Accessions:
    • Q5SYW7
    • Q5SYW8
    • Q5SYX3
    • Q5VWU2
    • Q5VWU3
    • Q5VWU4
    • Q6KCM4
    • Q6KCM6
    • Q6UX48
    • Q705K2
    • Q96PZ1
    • Q9BSA6

    Protein attributes for SLC25A25 Gene

    Size:
    469 amino acids
    Molecular mass:
    52663 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67789.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13826.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A25 Gene

neXtProt entry for SLC25A25 Gene

Post-translational modifications for SLC25A25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A25 Gene

Domains & Families for SLC25A25 Gene

Suggested Antigen Peptide Sequences for SLC25A25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6KCM7

UniProtKB/Swiss-Prot:

SCMC2_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A25: view

Function for SLC25A25 Gene

Molecular function for SLC25A25 Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

Gene Ontology (GO) - Molecular Function for SLC25A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005347 ATP transmembrane transporter activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0015217 ADP transmembrane transporter activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SLC25A25: view
genes like me logo Genes that share phenotypes with SLC25A25: view

Animal Models for SLC25A25 Gene

MGI Knock Outs for SLC25A25:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A25

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A25 Gene

Localization for SLC25A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A25 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A25 gene
Compartment Confidence
extracellular 5
mitochondrion 5
plasma membrane 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC25A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SLC25A25: view

Pathways & Interactions for SLC25A25 Gene

SuperPathways for SLC25A25 Gene

No Data Available

Interacting Proteins for SLC25A25 Gene

Gene Ontology (GO) - Biological Process for SLC25A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002021 response to dietary excess IEA --
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IBA --
GO:0014823 response to activity IEA --
GO:0015866 ADP transport IEA --
genes like me logo Genes that share ontologies with SLC25A25: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A25 Gene

Drugs & Compounds for SLC25A25 Gene

(1) Drugs for SLC25A25 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SLC25A25: view

Transcripts for SLC25A25 Gene

Unigene Clusters for SLC25A25 Gene

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for SLC25A25 Gene

GeneLoc Exon Structure for
SLC25A25
ECgene alternative splicing isoforms for
SLC25A25

Expression for SLC25A25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A25 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A25 Gene

This gene is overexpressed in Liver (x4.7).

Protein differential expression in normal tissues from HIPED for SLC25A25 Gene

This gene is overexpressed in Fetal gut (20.2), Heart (14.6), Urinary Bladder (7.4), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A25 Gene



Protein tissue co-expression partners for SLC25A25 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A25 Gene:

SLC25A25

SOURCE GeneReport for Unigene cluster for SLC25A25 Gene:

Hs.5476

mRNA Expression by UniProt/SwissProt for SLC25A25 Gene:

Q6KCM7-SCMC2_HUMAN
Tissue specificity: Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung.

Evidence on tissue expression from TISSUES for SLC25A25 Gene

  • Muscle(4.4)
  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with SLC25A25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A25 Gene

Orthologs for SLC25A25 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A25 34 35
  • 99.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SLC25A25 34 35
  • 91.93 (n)
dog
(Canis familiaris)
Mammalia SLC25A25 34 35
  • 91.17 (n)
mouse
(Mus musculus)
Mammalia Slc25a25 34 16 35
  • 89.44 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a25 34
  • 89.29 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A25 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A25 34 35
  • 81.39 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a25 34
  • 75.68 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a25b 34 35
  • 76.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006508 34
  • 60.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32103 34 35
  • 59.96 (n)
worm
(Caenorhabditis elegans)
Secernentea F17E5.2 34 35
  • 53.73 (n)
F55A11.4 35
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5381 35
  • 46 (a)
OneToMany
Species where no ortholog for SLC25A25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A25 Gene

ENSEMBL:
Gene Tree for SLC25A25 (if available)
TreeFam:
Gene Tree for SLC25A25 (if available)

Paralogs for SLC25A25 Gene

Paralogs for SLC25A25 Gene

(7) SIMAP similar genes for SLC25A25 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC25A25: view

Variants for SLC25A25 Gene

Sequence variations from dbSNP and Humsavar for SLC25A25 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000029633 -- 128,075,870(+) GAGTT(A/G)TTACT intron-variant
rs1000057772 -- 128,093,765(+) CTGAA(A/G)GTGTT intron-variant
rs1000158578 -- 128,104,412(+) CTCCC(C/G)AGTCT intron-variant
rs1000191648 -- 128,068,882(+) TTTGT(A/C)ACCTC intron-variant, upstream-variant-2KB
rs1000283826 -- 128,087,459(+) AATGG(A/G)TCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A25 Gene

Variant ID Type Subtype PubMed ID
nsv1054891 CNV gain 25217958
nsv1118368 CNV deletion 24896259
nsv471324 CNV gain 18288195
nsv518112 CNV loss 19592680
nsv615383 CNV loss 21841781
nsv6723 CNV deletion 18451855
nsv818724 CNV loss 17921354
nsv831727 CNV loss 17160897
nsv951769 CNV deletion 24416366

Variation tolerance for SLC25A25 Gene

Residual Variation Intolerance Score: 3.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A25 Gene

Disorders for SLC25A25 Gene

Relevant External Links for SLC25A25

Genetic Association Database (GAD)
SLC25A25
Human Genome Epidemiology (HuGE) Navigator
SLC25A25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A25

No disorders were found for SLC25A25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A25 Gene

Publications for SLC25A25 Gene

  1. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. (PMID: 15123600) Fiermonte G. … Palmieri F. (J. Biol. Chem. 2004) 2 3 4 64
  2. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. (PMID: 15054102) del Arco A. … Satrustegui J. (J. Biol. Chem. 2004) 3 4 22 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 46 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for SLC25A25 Gene

Sources for SLC25A25 Gene

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