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Aliases for SLC25A25 Gene

Aliases for SLC25A25 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 25 2 3
  • Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 3 3 4
  • Mitochondrial ATP-Mg/Pi Carrier Protein 3 3 4
  • Calcium-Binding Mitochondrial Carrier Protein SCaMC-2 3
  • Small Calcium-Binding Mitochondrial Carrier Protein 2 4
  • Short Calcium-Binding Mitochondrial Carrier 2 3
  • Small Calcium-Binding Mitochondrial Carrier 2 3
  • Solute Carrier Family 25, Member 25 3
  • Solute Carrier Family 25 Member 25 4
  • KIAA1896 4
  • SCAMC-2 3
  • SCAMC2 4
  • PCSCL 3
  • MCSC3 4
  • MCSC 3
  • APC3 4

External Ids for SLC25A25 Gene

Previous GeneCards Identifiers for SLC25A25 Gene

  • GC09P126209
  • GC09P127933
  • GC09P129870
  • GC09P130831
  • GC09P100445

Summaries for SLC25A25 Gene

Entrez Gene Summary for SLC25A25 Gene

  • The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for SLC25A25 Gene

SLC25A25 (Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 25) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SLC25A42.

UniProtKB/Swiss-Prot for SLC25A25 Gene

  • Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A25 Gene

Genomics for SLC25A25 Gene

Regulatory Elements for SLC25A25 Gene

Genomic Location for SLC25A25 Gene

Start:
128,068,200 bp from pter
End:
128,109,258 bp from pter
Size:
41,059 bases
Orientation:
Plus strand

Genomic View for SLC25A25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A25 Gene

Proteins for SLC25A25 Gene

  • Protein details for SLC25A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6KCM7-SCMC2_HUMAN
    Recommended name:
    Calcium-binding mitochondrial carrier protein SCaMC-2
    Protein Accession:
    Q6KCM7
    Secondary Accessions:
    • Q5SYW7
    • Q5SYW8
    • Q5SYX3
    • Q5VWU2
    • Q5VWU3
    • Q5VWU4
    • Q6KCM4
    • Q6KCM6
    • Q6UX48
    • Q705K2
    • Q96PZ1
    • Q9BSA6

    Protein attributes for SLC25A25 Gene

    Size:
    469 amino acids
    Molecular mass:
    52663 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67789.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13826.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A25 Gene

neXtProt entry for SLC25A25 Gene

Proteomics data for SLC25A25 Gene at MOPED

Post-translational modifications for SLC25A25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A25 Gene

Domains for SLC25A25 Gene

Gene Families for SLC25A25 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • SLC :Solute carriers
IUPHAR :

Suggested Antigen Peptide Sequences for SLC25A25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6KCM7

UniProtKB/Swiss-Prot:

SCMC2_HUMAN :
  • Q6KCM7
Domain:
  • Contains 3 EF-hand domains.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A25: view

Function for SLC25A25 Gene

Molecular function for SLC25A25 Gene

UniProtKB/Swiss-Prot Function: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

Gene Ontology (GO) - Molecular Function for SLC25A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with SLC25A25: view
genes like me logo Genes that share phenotypes with SLC25A25: view

Animal Models for SLC25A25 Gene

MGI Knock Outs for SLC25A25:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC25A25 Gene

Localization for SLC25A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A25 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A25 Gene COMPARTMENTS Subcellular localization image for SLC25A25 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC25A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SLC25A25: view

Pathways for SLC25A25 Gene

SuperPathways for SLC25A25 Gene

No Data Available

Interacting Proteins for SLC25A25 Gene

Gene Ontology (GO) - Biological Process for SLC25A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002021 response to dietary excess IEA --
GO:0014823 response to activity IEA --
GO:0032094 response to food IEA --
GO:0035264 multicellular organism growth IEA --
GO:0043010 camera-type eye development IEA --
genes like me logo Genes that share ontologies with SLC25A25: view

No data available for Pathways by source for SLC25A25 Gene

Compounds for SLC25A25 Gene

(1) HMDB Compounds for SLC25A25 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SLC25A25: view

Transcripts for SLC25A25 Gene

Unigene Clusters for SLC25A25 Gene

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for SLC25A25 Gene

GeneLoc Exon Structure for
SLC25A25
ECgene alternative splicing isoforms for
SLC25A25

Expression for SLC25A25 Gene

mRNA expression in normal human tissues for SLC25A25 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A25 Gene

This gene is overexpressed in Liver (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A25 Gene

SOURCE GeneReport for Unigene cluster for SLC25A25 Gene Hs.5476

mRNA Expression by UniProt/SwissProt for SLC25A25 Gene

Q6KCM7-SCMC2_HUMAN
Tissue specificity: Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung.
genes like me logo Genes that share expressions with SLC25A25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC25A25 Gene

Orthologs for SLC25A25 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A25 35
  • 99.73 (n)
  • 99.8 (a)
SLC25A25 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A25 35
  • 91.93 (n)
  • 97.6 (a)
SLC25A25 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A25 35
  • 91.17 (n)
  • 97.21 (a)
SLC25A25 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a25 35
  • 89.44 (n)
  • 96.02 (a)
Slc25a25 16
Slc25a25 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A25 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc25a25 35
  • 89.29 (n)
  • 97.36 (a)
chicken
(Gallus gallus)
Aves SLC25A25 35
  • 81.39 (n)
  • 90.87 (a)
SLC25A25 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a25 35
  • 75.68 (n)
  • 84.49 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a25b 35
  • 76.42 (n)
  • 88.01 (a)
slc25a25b 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006508 35
  • 60.75 (n)
  • 57.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32103 35
  • 59.96 (n)
  • 57.05 (a)
CG32103 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F17E5.2 35
  • 53.73 (n)
  • 50.78 (a)
F17E5.2 36
  • 43 (a)
ManyToMany
F55A11.4 36
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5381 36
  • 46 (a)
OneToMany
Species with no ortholog for SLC25A25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A25 Gene

ENSEMBL:
Gene Tree for SLC25A25 (if available)
TreeFam:
Gene Tree for SLC25A25 (if available)

Paralogs for SLC25A25 Gene

Paralogs for SLC25A25 Gene

Selected SIMAP similar genes for SLC25A25 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC25A25: view

Variants for SLC25A25 Gene

Sequence variations from dbSNP and Humsavar for SLC25A25 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2517 -- 128,092,756(+) ATTTC(A/G)TAGAT intron-variant
rs947622 -- 128,104,440(-) TGTGC(A/G)ACACA intron-variant
rs947623 -- 128,098,760(-) TTGAA(C/T)GCGCC intron-variant, nc-transcript-variant, utr-variant-5-prime
rs947624 -- 128,098,587(-) GGCAC(A/G)TACAG intron-variant, upstream-variant-2KB, synonymous-codon, reference
rs1418420 -- 128,106,552(+) AAACC(C/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A25 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv831727 CNV Loss 17160897
nsv471324 CNV Gain 18288195
nsv518112 CNV Loss 19592680
nsv893890 CNV Loss 21882294
nsv818724 CNV Loss 17921354
nsv893891 CNV Loss 21882294
dgv8294n71 CNV Loss 21882294
nsv6723 CNV Loss 18451855

Relevant External Links for SLC25A25 Gene

HapMap Linkage Disequilibrium report
SLC25A25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A25 Gene

Disorders for SLC25A25 Gene

Relevant External Links for SLC25A25

Genetic Association Database (GAD)
SLC25A25
Human Genome Epidemiology (HuGE) Navigator
SLC25A25
genes like me logo Genes that share disorders with SLC25A25: view

No data available for UniProtKB/Swiss-Prot for SLC25A25 Gene

Publications for SLC25A25 Gene

  1. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. (PMID: 15054102) del Arco A. … Satrustegui J. (J. Biol. Chem. 2004) 3 4 23
  2. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. (PMID: 15123600) Fiermonte G. … Palmieri F. (J. Biol. Chem. 2004) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  5. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 48

Products for SLC25A25 Gene

Sources for SLC25A25 Gene

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