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SLC25A25 Gene

protein-coding   GIFtS: 50
GCID: GC09P130831

Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate...

  Search for SLC25A25
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier),
Member 251 2
     Small Calcium-Binding Mitochondrial Carrier 22
Mitochondrial ATP-Mg/Pi Carrier Protein 32 3     Solute Carrier Family 25, Member 252
Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 32 3     APC33
MCSC2     KIAA18963
PCSCL2     MCSC33
SCAMC-22     SCAMC23
Calcium-Binding Mitochondrial Carrier Protein SCaMC-22     Small Calcium-Binding Mitochondrial Carrier Protein 23
Short Calcium-Binding Mitochondrial Carrier 22     Solute Carrier Family 25 Member 253

External Ids:    HGNC: 206631   Entrez Gene: 1147892   Ensembl: ENSG000001483397   OMIM: 6087455   UniProtKB: Q6KCM73   

Export aliases for SLC25A25 gene to outside databases

Previous GC identifers: GC09P126209 GC09P127933 GC09P129870 GC09P100445


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A25 Gene:
The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a
characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of
mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the
mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may
function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely
responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively
spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been
described for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for SLC25A25 Gene:
SLC25A25 (solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SLC25A24.

UniProtKB/Swiss-Prot: SCMC2_HUMAN, Q6KCM7
Function: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites,
nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that
mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine
nucleotides into or from the mitochondria




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A25 gene promoter:
         CREB   FAC1   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC25A25 promoter sequence
   Search Chromatin IP Primers for SLC25A25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34

SLC25A25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A25 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P130831:  view genomic region     (about GC identifiers)

Start:
130,830,479 bp from pter      End:
130,871,524 bp from pter
Size:
41,046 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCMC2_HUMAN, Q6KCM7 (See protein sequence)
Recommended Name: Calcium-binding mitochondrial carrier protein SCaMC-2  
Size: 469 amino acids; 52663 Da
Sequence caution: Sequence=BAB67789.1; Type=Erroneous initiation; Sequence=CAH73133.1; Type=Erroneous gene model
prediction; Sequence=CAI13826.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5SYW7 Q5SYW8 Q5SYX3 Q5VWU2 Q5VWU3 Q5VWU4 Q6KCM4 Q6KCM6 Q6UX48 Q705K2
Q96PZ1 Q9BSA6
Alternative splicing: 6 isoforms:  Q6KCM7-1   Q6KCM7-2   Q6KCM7-3   Q6KCM7-4   Q6KCM7-5   Q6KCM7-6   

Explore the universe of human proteins at neXtProt for SLC25A25: NX_Q6KCM7

Explore proteomics data for SLC25A25 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC25A25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001006642.1  NP_001006643.1  NP_001252543.1  NP_443133.2  

    ENSEMBL proteins: 
     ENSP00000362159   ENSP00000362160   ENSP00000362157   ENSP00000410053   ENSP00000362155  
     ENSP00000419685   ENSP00000418600   ENSP00000401672  

    SLC25A25 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SLC25A25
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    Novus Biologicals SLC25A25 Proteins
    Novus Biologicals SLC25A25 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC25A25 

    SLC25A25 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for SLC25A25
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SLC25A25
    LSBio Antibodies in human, mouse, rat for SLC25A25

    SLC25A25 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC25A25 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers
    EFHAND: EF-hand domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial phosphate carrier 3
    Miscellaneous SLC25 mitochondrial transporters

    Selected InterPro protein domains (see all 6):
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR002067 Mit_carrier
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q6KCM7

    ProtoNet protein and cluster: Q6KCM7

    1 Blocks protein domain: IPB002067 Mitochondrial carrier protein signature

    UniProtKB/Swiss-Prot: SCMC2_HUMAN, Q6KCM7
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 EF-hand domains
    Similarity: Contains 3 Solcar repeats


    Find genes that share domains with SLC25A25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCMC2_HUMAN, Q6KCM7
    Function: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites,
    nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that
    mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine
    nucleotides into or from the mitochondria

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with SLC25A25           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc25a25):
     adipose tissue  behavior/neurological  cellular  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle  vision/eye 

    Find genes that share phenotypes with SLC25A25           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc25a25tm1.1Kz for SLC25A25

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A25
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC25A25
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC25A25

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC25A25 (see all 50):
    hsa-miR-4291 hsa-miR-607 hsa-miR-1197 hsa-miR-3664-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-1258 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A25

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    GenScript: all cDNA clones in your preferred vector (see all 4): SLC25A25 (NM_001006641)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A25

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCMC2_HUMAN, Q6KCM7: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with SLC25A25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A25: 
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC25A25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SLC25A25 (ENSP000003621594) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SURF1ENSP000003610424STRING: ENSP00000361042
    MTG1ENSP000003230474STRING: ENSP00000323047
    SLC25A31ENSP000002811544STRING: ENSP00000281154
    SLC25A4ENSP000002814564STRING: ENSP00000281456
    SLC25A5ENSP000003606714STRING: ENSP00000360671
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002021response to dietary excess IEA--
    GO:0014823response to activity IEA--
    GO:0032094response to food IEA--
    GO:0035264multicellular organism growth IEA--
    GO:0043010camera-type eye development IEA--

    Find genes that share ontologies with SLC25A25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC25A25 (SCMC2)

    1 HMDB Compound for SLC25A25    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC25A25 gene (5 alternative transcripts): 
    NM_001006641.3  NM_001006642.3  NM_001265614.2  NM_052901.4  NM_001006643.1  

    Unigene Cluster for SLC25A25:

    Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
    Hs.5476  [show with all ESTs]
    Unigene Representative Sequence: NM_001265614
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373068(uc004btb.3) ENST00000373069 ENST00000373066(uc004btd.3)
    ENST00000432073(uc004btc.3) ENST00000373064(uc004bte.3) ENST00000472769
    ENST00000445012 ENST00000466983 ENST00000433501(uc004btf.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC25A25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC25A25 (see all 50):
    hsa-miR-4291 hsa-miR-607 hsa-miR-1197 hsa-miR-3664-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-1258 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A25
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    GenScript: all cDNA clones in your preferred vector (see all 4): SLC25A25 (NM_001006641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A25
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A25
      QuantiTect SYBR Green Assays in human, mouse, rat SLC25A25
      QuantiFast Probe-based Assays in human, mouse, rat SLC25A25

    Additional mRNA sequence: 

    AB067483.1 AJ619963.1 AJ619989.1 AJ619990.1 AJ619991.1 AJ619992.1 AK290705.1 AK290991.1 
    AY358515.1 BC005163.2 BC036889.1 BC044631.1 BC061925.1 BC089448.1 BC103930.1 BC103931.1 
    BC103932.1 BC103933.1 BC109189.1 NR_049766.2 

    11 DOTS entries:

    DT.95274234  DT.100842904  DT.92379286  DT.99950577  DT.87016968  DT.102822289  DT.100764014  DT.121194289 
    DT.121194411  DT.91850643  DT.121194406 

    Selected AceView cDNA sequences (see all 206):

    BF870977 CA488675 CF529771 BM696461 BE645945 AJ619989 BQ719917 BC005163 
    BF870756 BF589689 BE269761 AJ619991 CR598512 BM717718 F15662 AW954916 
    AI291496 AJ619990 AI582469 BU180942 AA325835 BM854971 AI992287 BM053088 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A25 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:        -     -     -     -                                                                           
    SP2:                    -     -                 -                                                         
    SP3:        -     -     -     -                 -                                                         
    SP4:                          -                 -                                                         
    SP5:                                            -                                                         


    ECgene alternative splicing isoforms for SLC25A25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC25A25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGATTGTA
    SLC25A25 Expression
    About this image

    SLC25A25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC25A25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5476

    UniProtKB/Swiss-Prot: SCMC2_HUMAN, Q6KCM7
    Tissue specificity: Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and
    adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues
    tested. Isoform 2 expression is restricted to kidney and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A25: 
              Mitochondria in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SLC25A25
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC25A25 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a251 , 5 solute carrier family 25 (mitochondrial carrier, phosphate more1, 5 89.44(n)1
    96.02(a)1
      2 (22.09 cM)5
    2277311  NM_146118.31  NP_666230.21 
     324144875 
    chicken
    (Gallus gallus)
    Aves SLC25A251 solute carrier family 25 (mitochondrial carrier; phosphate more 81.39(n)
    90.87(a)
      417230  XM_004945811.1  XP_004945868.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043834.12   -- 79.5(n)    BC043834.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK141395.12   -- 77.69(n)    CK141395.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321031 CG32103 59.96(n)
    57.05(a)
      39415  NM_206345.2  NP_996067.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F17E5.21 F17E5.2 53.73(n)
    50.78(a)
      181399  NM_077680.5  NP_510081.3 


    ENSEMBL Gene Tree for SLC25A25 (if available)
    TreeFam Gene Tree for SLC25A25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC25A25 gene
    SLC25A242  SLC25A232  SLC25A422  SLC25A412  SLC25A162  SLC25A432  
    7 SIMAP similar genes for SLC25A25 using alignment to 4 protein entries:     SCMC2_HUMAN (see all proteins):
    SLC25A24    SLC25A23    SLC25A41    SLC25A19    SLC25A6    SLC25A4
    SLC25A14

    Find genes that share paralogs with SLC25A25           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC25A25 (see all 1066)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs564080331,2
    C--130833847(+) TTTTTT/-GTATT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1130557351,2
    F--130836327(+) TTTTTG/TTGTGT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs114033071,2
    C--130836627(+) TTTTT-/TAATAA 1 -- int10--------
    rs340545131,2
    C--130837787(+) ACCCC-/CATCTC 1 -- int11Minor allele frequency- C:0.00CSA 2
    rs1434310591,2
    C--130840679(+) CCCAG-/GGAGACAT 1 -- int10--------
    rs105790391,2
    C--130840680(+) CCAGG-/GAGACATA 2 -- int1 cds12Minor allele frequency- GAG:0.25NA 4
    rs2017743621,2
    C--130841709(+) AAAAA-/AAGGGTGG 1 -- int10--------
    rs1150986281,2
    F--130841820(+) CAAGCC/TGGGCC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs2019470111,2
    C--130842167(+) GGTGAC/GCGTGG 1 -- us2k11Minor allele frequency- G:0.00EU 693
    rs15393501,2
    C,F,H--130842321(+) CCGCCG/ACCACT 1 -- us2k113Minor allele frequency- A:0.01NA CSA WA EA EU 4827

    HapMap Linkage Disequilibrium report for SLC25A25 (130830479 - 130871524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SLC25A25:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv8294n71CNV Loss21882294
    nsv518112CNV Loss19592680
    nsv6723CNV Loss18451855
    nsv893890CNV Loss21882294
    nsv818724CNV Loss17921354
    nsv893891CNV Loss21882294
    nsv831727CNV Loss17160897
    nsv893859CNV Loss21882294
    nsv471324CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC25A25
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608745    OMIM disorders: --


    Find genes that share disorders with SLC25A25           About GenesLikeMe

    Genetic Association Database (GAD): SLC25A25
    Human Genome Epidemiology (HuGE) Navigator: SLC25A25 (2 documents)

    Export disorders for SLC25A25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC25A25 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SLC25A25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. (PubMed id 15123600)1, 2, 3 Fiermonte G....Palmieri F. (J. Biol. Chem. 2004)
    2. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. (PubMed id 15054102)1, 2, 9 del Arco A. and Satrustegui J. (J. Biol. Chem. 2004)
    3. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    7. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (Mol. Aspects Med. 2013)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114789 HGNC: 20663 AceView: SLC25A25 Ensembl:ENSG00000148339 euGenes: HUgn114789
    ECgene: SLC25A25 H-InvDB: SLC25A25

    (According to HUGE)
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    HUGE: KIAA1896

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC25A25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC25A25 gene:
    Search GeneIP for patents involving SLC25A25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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