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Aliases for SLC25A24 Gene

Aliases for SLC25A24 Gene

  • Solute Carrier Family 25 Member 24 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 24 2 3
  • Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 1 3 4
  • Small Calcium-Binding Mitochondrial Carrier Protein 1 3 4
  • Mitochondrial ATP-Mg/Pi Carrier Protein 1 3 4
  • APC1 3 4
  • Calcium-Binding Mitochondrial Carrier Protein SCaMC-1 3
  • Short Calcium-Binding Mitochondrial Carrier 1 3
  • Calcium-Binding Transporter 3
  • SCAMC-1 3
  • SCAMC1 4
  • MCSC1 4

External Ids for SLC25A24 Gene

Previous GeneCards Identifiers for SLC25A24 Gene

  • GC01M108033
  • GC01M108389
  • GC01M108677
  • GC01M106625

Summaries for SLC25A24 Gene

Entrez Gene Summary for SLC25A24 Gene

  • This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for SLC25A24 Gene

SLC25A24 (Solute Carrier Family 25 Member 24) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and ATP transmembrane transporter activity. An important paralog of this gene is SLC25A25.

UniProtKB/Swiss-Prot for SLC25A24 Gene

  • Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A24 Gene

Genomics for SLC25A24 Gene

Regulatory Elements for SLC25A24 Gene

Enhancers for SLC25A24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F108197 1.4 FANTOM5 ENCODE 31.8 +1.2 1207 3.9 CREB3L1 WRNIP1 SIN3A ZNF2 YY1 FOS SP3 ZHX2 REST SMARCB1 SLC25A24 PRPF38B RPL17P7 ENSG00000226822 FAM102B ENSG00000260879 PIR34396
GH01F108501 1.1 Ensembl ENCODE 11.6 -302.0 -302010 1.8 GTF2F1 TBP TEAD4 RAD21 BRCA1 RFX5 TEAD3 ZNF664 ZNF316 RCOR1 FAM102B SLC25A24 PRPF38B ST13P21 LOC100420170
GH01F108118 1.3 FANTOM5 Ensembl 9.6 +82.4 82449 0.8 CBX3 SREBF2 SIN3A ELK1 ZNF366 SCRT2 ZNF143 ZNF207 ZNF548 FOS PRPF38B RPL17P7 SLC25A24 ENSG00000226822 FAM102B PIR34712 GC01M108027
GH01F108152 0.7 FANTOM5 Ensembl 12.6 +48.0 48029 0.8 IKZF1 SLC25A24 ENSG00000226822 FAM102B GC01M108145 PIR34712
GH01F108077 1.5 FANTOM5 Ensembl ENCODE 5.8 +120.6 120593 6.3 HDAC1 PKNOX1 CBX3 ATF1 TBL1XR1 ZNF133 GATA2 ZNF143 FOS KDM4B ENSG00000226822 VAV3 VAV3-AS1 FAM102B SLC25A24 GC01M108027 PIR34712
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A24 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000542233 749 2601 CREB3L1 WRNIP1 SIN3A FEZF1 ZNF2 FOS SP3 ZHX2 REST SMARCB1

Genomic Location for SLC25A24 Gene

Chromosome:
1
Start:
108,134,036 bp from pter
End:
108,200,849 bp from pter
Size:
66,814 bases
Orientation:
Minus strand

Genomic View for SLC25A24 Gene

Genes around SLC25A24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A24 Gene

Proteins for SLC25A24 Gene

  • Protein details for SLC25A24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUK1-SCMC1_HUMAN
    Recommended name:
    Calcium-binding mitochondrial carrier protein SCaMC-1
    Protein Accession:
    Q6NUK1
    Secondary Accessions:
    • B7ZAI9
    • Q5T331
    • Q5T485
    • Q6PJJ9
    • Q705K4
    • Q9P129

    Protein attributes for SLC25A24 Gene

    Size:
    477 amino acids
    Molecular mass:
    53354 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28888.1; Type=Frameshift; Positions=418, 464; Evidence={ECO:0000305}; Sequence=CAI13622.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14512.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC25A24 Gene

    Alternative splice isoforms for SLC25A24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A24 Gene

Post-translational modifications for SLC25A24 Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A24 Gene

No data available for DME Specific Peptides for SLC25A24 Gene

Domains & Families for SLC25A24 Gene

Suggested Antigen Peptide Sequences for SLC25A24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NUK1

UniProtKB/Swiss-Prot:

SCMC1_HUMAN :
  • The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (PubMed:24332718).
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Domain:
  • The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (PubMed:24332718).
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A24: view

Function for SLC25A24 Gene

Molecular function for SLC25A24 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.97 mM for AMP {ECO:0000269 PubMed:15123600}; KM=0.3 mM for ADP {ECO:0000269 PubMed:15123600}; KM=0.33 mM for ATP {ECO:0000269 PubMed:15123600}; KM=0.2 mM for ATP-Mg {ECO:0000269 PubMed:15123600}; KM=1.64 mM for Pi {ECO:0000269 PubMed:15123600}; Vmax=337 umol/min/g enzyme with AMP as substrate {ECO:0000269 PubMed:15123600}; Vmax=345 umol/min/g enzyme with ADP as substrate {ECO:0000269 PubMed:15123600}; Vmax=320 umol/min/g enzyme with ATP as substrate {ECO:0000269 PubMed:15123600}; Vmax=365 umol/min/g enzyme with ATP-Mg as substrate {ECO:0000269 PubMed:15123600}; Vmax=380 umol/min/g enzyme with Pi as substrate {ECO:0000269 PubMed:15123600};
UniProtKB/Swiss-Prot Function:
Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.

Gene Ontology (GO) - Molecular Function for SLC25A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005347 ATP transmembrane transporter activity IMP 22015608
GO:0005509 calcium ion binding IEA,IDA 24332718
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SLC25A24: view
genes like me logo Genes that share phenotypes with SLC25A24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A24

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A24 Gene

Localization for SLC25A24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A24 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A24 gene
Compartment Confidence
mitochondrion 5
cytosol 3
peroxisome 2
plasma membrane 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC25A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 22015608
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 24332718
genes like me logo Genes that share ontologies with SLC25A24: view

Pathways & Interactions for SLC25A24 Gene

SuperPathways for SLC25A24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006839 mitochondrial transport IMP 22015608
GO:0010941 regulation of cell death IMP 22015608
GO:0015867 ATP transport IMP 22015608
GO:0034599 cellular response to oxidative stress IMP 22015608
genes like me logo Genes that share ontologies with SLC25A24: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A24 Gene

Drugs & Compounds for SLC25A24 Gene

(1) Drugs for SLC25A24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SLC25A24: view

Transcripts for SLC25A24 Gene

Unigene Clusters for SLC25A24 Gene

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A24 Gene

No ASD Table

Relevant External Links for SLC25A24 Gene

GeneLoc Exon Structure for
SLC25A24
ECgene alternative splicing isoforms for
SLC25A24

Expression for SLC25A24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A24 Gene

This gene is overexpressed in Nasal epithelium (31.4) and Bone (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A24 Gene



Protein tissue co-expression partners for SLC25A24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A24 Gene:

SLC25A24

SOURCE GeneReport for Unigene cluster for SLC25A24 Gene:

Hs.656870

mRNA Expression by UniProt/SwissProt for SLC25A24 Gene:

Q6NUK1-SCMC1_HUMAN
Tissue specificity: Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with SLC25A24: view

Primer Products

No data available for mRNA differential expression in normal tissues for SLC25A24 Gene

Orthologs for SLC25A24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A24 34 35
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia SLC25A24 35
  • 95 (a)
OneToOne
LOC534742 34
  • 91.68 (n)
dog
(Canis familiaris)
Mammalia SLC25A24 34 35
  • 91.35 (n)
mouse
(Mus musculus)
Mammalia Slc25a24 34 16 35
  • 87.37 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a24 34
  • 86.88 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A24 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A24 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A24 34 35
  • 77.46 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 78 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a24 34
  • 70.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398474 34
zebrafish
(Danio rerio)
Actinopterygii zgc:92470 34
  • 65.41 (n)
SLC25A24 35
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32103 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F17E5.2 35
  • 40 (a)
ManyToMany
F55A11.4 35
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAL1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51050 34
  • 49.96 (n)
rice
(Oryza sativa)
Liliopsida Os.26881 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12D12.05c 34
  • 50.46 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01564 34
  • 47.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5381 35
  • 43 (a)
OneToMany
Species where no ortholog for SLC25A24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A24 Gene

ENSEMBL:
Gene Tree for SLC25A24 (if available)
TreeFam:
Gene Tree for SLC25A24 (if available)

Paralogs for SLC25A24 Gene

Paralogs for SLC25A24 Gene

(15) SIMAP similar genes for SLC25A24 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC25A24 Gene

genes like me logo Genes that share paralogs with SLC25A24: view

Variants for SLC25A24 Gene

Sequence variations from dbSNP and Humsavar for SLC25A24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10127755 -- 108,167,043(+) gagta(A/C)ccggc intron-variant
rs1020172 -- 108,153,180(+) CACTA(C/T)TACAC intron-variant
rs1020173 -- 108,153,279(+) ACATA(C/T)CAGGT intron-variant
rs1020174 -- 108,154,138(+) CGTAA(A/T)CTTCT intron-variant
rs10218750 -- 108,170,694(+) AATCT(A/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A24 Gene

Variant ID Type Subtype PubMed ID
dgv248n100 CNV gain 25217958
dgv469n54 CNV gain 21841781
dgv475n54 CNV loss 21841781
dgv476n54 CNV loss 21841781
dgv477n54 CNV loss 21841781
dgv478n54 CNV loss 21841781
dgv479n54 CNV loss 21841781
dgv480n54 CNV loss 21841781
dgv481n54 CNV loss 21841781
dgv482n54 CNV loss 21841781
dgv59e199 CNV deletion 23128226
dgv5e180 CNV gain 20482838
dgv62n67 CNV loss 20364138
dgv73e212 CNV loss 25503493
esv2122744 CNV deletion 18987734
nsv947441 CNV deletion 23825009
nsv823853 CNV loss 20364138
nsv823842 CNV gain 20364138
nsv820521 CNV deletion 20802225
nsv819227 CNV gain 19587683
nsv547396 CNV loss 21841781
nsv547393 CNV gain 21841781
nsv547358 CNV gain 21841781
nsv526757 CNV loss 19592680
nsv524680 CNV gain 19592680
nsv517978 CNV loss 19592680
nsv513999 CNV loss 21397061
nsv508459 CNV deletion 20534489
nsv498678 CNV loss 21111241
nsv442958 CNV loss 18776908
nsv433387 CNV loss 18776910
nsv428179 CNV gain 18775914
nsv2265 CNV deletion 18451855
nsv1161256 CNV deletion 26073780
nsv10539 CNV gain+loss 18304495
nsv1011093 CNV gain 25217958
nsv1007150 CNV gain 25217958
nsv1004890 CNV loss 25217958
esv9427 CNV loss 19470904
esv3739 CNV loss 18987735
esv3587126 CNV gain 21293372
esv3587125 CNV loss 21293372
esv3578071 CNV loss 25503493
esv3578068 CNV loss 25503493
esv3578065 CNV loss 25503493
esv3578060 CNV loss 25503493
esv3567170 CNV deletion 23714750
esv33273 CNV gain 17666407
esv32800 CNV loss 17666407
esv32547 CNV gain 17666407
esv2763802 CNV loss 21179565
esv2758958 CNV gain+loss 17122850
esv2715906 CNV deletion 23290073
esv2675031 CNV deletion 23128226
esv2665550 CNV deletion 23128226
esv2623047 CNV deletion 19546169
esv2498743 CNV loss 19546169
esv2421780 CNV deletion 20811451
esv22495 CNV loss 19812545
esv21858 CNV gain+loss 19812545

Variation tolerance for SLC25A24 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A24 Gene

Disorders for SLC25A24 Gene

Relevant External Links for SLC25A24

Genetic Association Database (GAD)
SLC25A24
Human Genome Epidemiology (HuGE) Navigator
SLC25A24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A24

No disorders were found for SLC25A24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A24 Gene

Publications for SLC25A24 Gene

  1. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. (PMID: 15123600) Fiermonte G. … Palmieri F. (J. Biol. Chem. 2004) 2 3 4 64
  2. A self-sequestered calmodulin-like Ca(2+) sensor of mitochondrial SCaMC carrier and its implication to Ca(2+)-dependent ATP-Mg/Pi transport. (PMID: 24332718) Yang Q. … Chou J.J. (Structure 2013) 3 4 64
  3. SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering. (PMID: 22015608) Traba J. … SatrA_stegui J. (Cell Death Differ. 2012) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64

Products for SLC25A24 Gene

Sources for SLC25A24 Gene

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