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Aliases for SLC25A24 Gene

Aliases for SLC25A24 Gene

  • Solute Carrier Family 25 Member 24 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 24 2 3
  • Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 1 3 4
  • Small Calcium-Binding Mitochondrial Carrier Protein 1 3 4
  • Mitochondrial ATP-Mg/Pi Carrier Protein 1 3 4
  • APC1 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier Phosphate Carrier), Member 24 5
  • Short Calcium-Binding Mitochondrial Carrier 1 3
  • Calcium-Binding Transporter 3
  • SCAMC-1 3
  • SCAMC1 4
  • MCSC1 4

External Ids for SLC25A24 Gene

Previous GeneCards Identifiers for SLC25A24 Gene

  • GC01M108033
  • GC01M108389
  • GC01M108677
  • GC01M106625

Summaries for SLC25A24 Gene

Entrez Gene Summary for SLC25A24 Gene

  • This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for SLC25A24 Gene

SLC25A24 (Solute Carrier Family 25 Member 24) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and ATP transmembrane transporter activity. An important paralog of this gene is SLC25A42.

UniProtKB/Swiss-Prot for SLC25A24 Gene

  • Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A24 Gene

Genomics for SLC25A24 Gene

Regulatory Elements for SLC25A24 Gene

Enhancers for SLC25A24 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A24 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A24 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A24 Gene

Chromosome:
1
Start:
108,134,036 bp from pter
End:
108,200,849 bp from pter
Size:
66,814 bases
Orientation:
Minus strand

Genomic View for SLC25A24 Gene

Genes around SLC25A24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A24 Gene

Proteins for SLC25A24 Gene

  • Protein details for SLC25A24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUK1-SCMC1_HUMAN
    Recommended name:
    Calcium-binding mitochondrial carrier protein SCaMC-1
    Protein Accession:
    Q6NUK1
    Secondary Accessions:
    • B7ZAI9
    • Q5T331
    • Q5T485
    • Q6PJJ9
    • Q705K4
    • Q9P129

    Protein attributes for SLC25A24 Gene

    Size:
    477 amino acids
    Molecular mass:
    53354 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28888.1; Type=Frameshift; Positions=418, 464; Evidence={ECO:0000305}; Sequence=CAI13622.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14512.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC25A24 Gene

    Alternative splice isoforms for SLC25A24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A24 Gene

Proteomics data for SLC25A24 Gene at MOPED

Post-translational modifications for SLC25A24 Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A24 Gene

Antibody Products

No data available for DME Specific Peptides for SLC25A24 Gene

Domains & Families for SLC25A24 Gene

Suggested Antigen Peptide Sequences for SLC25A24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NUK1

UniProtKB/Swiss-Prot:

SCMC1_HUMAN :
  • The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (PubMed:24332718).
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Domain:
  • The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (PubMed:24332718).
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A24: view

Function for SLC25A24 Gene

Molecular function for SLC25A24 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.97 mM for AMP {ECO:0000269 PubMed:15123600}; KM=0.3 mM for ADP {ECO:0000269 PubMed:15123600}; KM=0.33 mM for ATP {ECO:0000269 PubMed:15123600}; KM=0.2 mM for ATP-Mg {ECO:0000269 PubMed:15123600}; KM=1.64 mM for Pi {ECO:0000269 PubMed:15123600}; Vmax=337 umol/min/g enzyme with AMP as substrate {ECO:0000269 PubMed:15123600}; Vmax=345 umol/min/g enzyme with ADP as substrate {ECO:0000269 PubMed:15123600}; Vmax=320 umol/min/g enzyme with ATP as substrate {ECO:0000269 PubMed:15123600}; Vmax=365 umol/min/g enzyme with ATP-Mg as substrate {ECO:0000269 PubMed:15123600}; Vmax=380 umol/min/g enzyme with Pi as substrate {ECO:0000269 PubMed:15123600};
UniProtKB/Swiss-Prot Function:
Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.
genes like me logo Genes that share phenotypes with SLC25A24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A24

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A24 Gene

Localization for SLC25A24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A24 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A24 Gene COMPARTMENTS Subcellular localization image for SLC25A24 gene
Compartment Confidence
mitochondrion 5
cytosol 3
peroxisome 2
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC25A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with SLC25A24: view

Pathways & Interactions for SLC25A24 Gene

SuperPathways for SLC25A24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0015867 ATP transport IMP 22015608
GO:0034599 cellular response to oxidative stress IMP 22015608
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A24: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A24 Gene

Drugs & Compounds for SLC25A24 Gene

(1) Drugs for SLC25A24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SLC25A24: view

Transcripts for SLC25A24 Gene

Unigene Clusters for SLC25A24 Gene

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A24 Gene

No ASD Table

Relevant External Links for SLC25A24 Gene

GeneLoc Exon Structure for
SLC25A24
ECgene alternative splicing isoforms for
SLC25A24

Expression for SLC25A24 Gene

mRNA expression in normal human tissues for SLC25A24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A24 Gene

This gene is overexpressed in Nasal epithelium (31.4) and Bone (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A24 Gene



SOURCE GeneReport for Unigene cluster for SLC25A24 Gene Hs.656870

mRNA Expression by UniProt/SwissProt for SLC25A24 Gene

Q6NUK1-SCMC1_HUMAN
Tissue specificity: Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with SLC25A24: view

Protein tissue co-expression partners for SLC25A24 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC25A24 Gene

Orthologs for SLC25A24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC534742 35
  • 91.68 (n)
  • 94.76 (a)
SLC25A24 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A24 35
  • 91.35 (n)
  • 91.59 (a)
SLC25A24 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a24 35
  • 87.37 (n)
  • 93.68 (a)
Slc25a24 16
Slc25a24 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A24 35
  • 99.72 (n)
  • 99.58 (a)
SLC25A24 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a24 35
  • 86.88 (n)
  • 92.84 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A24 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A24 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A24 35
  • 77.46 (n)
  • 79.62 (a)
SLC25A24 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a24 35
  • 70.68 (n)
  • 72.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398474 35
zebrafish
(Danio rerio)
Actinopterygii zgc:92470 35
  • 65.41 (n)
  • 65.76 (a)
SLC25A24 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32103 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F17E5.2 36
  • 40 (a)
ManyToMany
F55A11.4 36
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51050 35
  • 49.96 (n)
  • 43.18 (a)
rice
(Oryza sativa)
Liliopsida Os.26881 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01564 35
  • 47.03 (n)
  • 40.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12D12.05c 35
  • 50.46 (n)
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5381 36
  • 43 (a)
OneToMany
Species with no ortholog for SLC25A24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A24 Gene

ENSEMBL:
Gene Tree for SLC25A24 (if available)
TreeFam:
Gene Tree for SLC25A24 (if available)

Paralogs for SLC25A24 Gene

Paralogs for SLC25A24 Gene

(15) SIMAP similar genes for SLC25A24 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC25A24 Gene

genes like me logo Genes that share paralogs with SLC25A24: view

Variants for SLC25A24 Gene

Sequence variations from dbSNP and Humsavar for SLC25A24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs476386 -- 108,194,964(+) TATTA(C/T)ATCCA intron-variant
rs479537 -- 108,175,054(+) cgctg(A/G)gggac intron-variant
rs481267 -- 108,175,198(+) gtcac(A/G)ggagg intron-variant
rs483253 -- 108,175,422(+) aaagt(A/G)agtca intron-variant
rs490680 -- 108,181,896(+) TGCAG(A/G)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A24 Gene

Variant ID Type Subtype PubMed ID
nsv524680 CNV Gain 19592680
dgv83e1 CNV Complex 17122850
nsv428179 CNV Gain 18775914
nsv517978 CNV Loss 19592680
nsv872136 CNV Loss 21882294
nsv508459 CNV Loss 20534489
esv22495 CNV Loss 19812545
dgv84e1 CNV Complex 17122850
esv32800 CNV Loss 17666407
nsv2265 CNV Loss 18451855
esv33273 CNV Gain 17666407
nsv526757 CNV Loss 19592680
esv32547 CNV Gain 17666407
nsv10539 CNV Gain+Loss 18304495
esv2665550 CNV Deletion 23128226
esv2498743 CNV Loss 19546169
esv2623047 CNV Deletion 19546169
nsv820521 CNV Deletion 20802225
nsv823842 CNV Gain 20364138
esv2122744 CNV Deletion 18987734
nsv823853 CNV Loss 20364138
esv3739 CNV Deletion 18987735
dgv5e180 CNV Gain 20482838
dgv62n67 CNV Loss 20364138
esv2715906 CNV Deletion 23290073
esv9427 CNV Loss 19470904
nsv819227 CNV Gain 19587683
nsv498678 CNV Loss 21111241
esv2675031 CNV Deletion 23128226
dgv59e199 CNV Deletion 23128226
esv21858 CNV Gain+Loss 19812545
nsv433387 CNV Loss 18776910
esv2421780 CNV Deletion 20811451
nsv513999 CNV Loss 21397061
nsv442958 CNV CNV 18776908

Variation tolerance for SLC25A24 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A24 Gene

HapMap Linkage Disequilibrium report
SLC25A24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A24 Gene

Disorders for SLC25A24 Gene

Relevant External Links for SLC25A24

Genetic Association Database (GAD)
SLC25A24
Human Genome Epidemiology (HuGE) Navigator
SLC25A24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A24

No disorders were found for SLC25A24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A24 Gene

Publications for SLC25A24 Gene

  1. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. (PMID: 15123600) Fiermonte G. … Palmieri F. (J. Biol. Chem. 2004) 2 3 4 67
  2. SLC25A24 as a novel susceptibility gene for low fat mass in humans and mice. (PMID: 25599384) Urano T. … Inoue S. (J. Clin. Endocrinol. Metab. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SLC25A24 Gene

Sources for SLC25A24 Gene

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