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Aliases for SLC25A24 Gene

Aliases for SLC25A24 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 24 2 3
  • Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 1 3 4
  • Small Calcium-Binding Mitochondrial Carrier Protein 1 3 4
  • Mitochondrial ATP-Mg/Pi Carrier Protein 1 3 4
  • APC1 3 4
  • Calcium-Binding Mitochondrial Carrier Protein SCaMC-1 3
  • Short Calcium-Binding Mitochondrial Carrier 1 3
  • Solute Carrier Family 25 Member 24 4
  • Calcium-Binding Transporter 3
  • SCAMC-1 3
  • SCAMC1 4
  • MCSC1 4

External Ids for SLC25A24 Gene

Previous GeneCards Identifiers for SLC25A24 Gene

  • GC01M108033
  • GC01M108389
  • GC01M108677
  • GC01M106625

Summaries for SLC25A24 Gene

Entrez Gene Summary for SLC25A24 Gene

  • This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for SLC25A24 Gene

SLC25A24 (Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 24) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SLC25A42.

UniProtKB/Swiss-Prot for SLC25A24 Gene

  • Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A24 Gene

Genomics for SLC25A24 Gene

Regulatory Elements for SLC25A24 Gene

Genomic Location for SLC25A24 Gene

Start:
108,134,036 bp from pter
End:
108,200,849 bp from pter
Size:
66,814 bases
Orientation:
Minus strand

Genomic View for SLC25A24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A24 Gene

Proteins for SLC25A24 Gene

  • Protein details for SLC25A24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUK1-SCMC1_HUMAN
    Recommended name:
    Calcium-binding mitochondrial carrier protein SCaMC-1
    Protein Accession:
    Q6NUK1
    Secondary Accessions:
    • B7ZAI9
    • Q5T331
    • Q5T485
    • Q6PJJ9
    • Q705K4
    • Q9P129

    Protein attributes for SLC25A24 Gene

    Size:
    477 amino acids
    Molecular mass:
    53354 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28888.1; Type=Frameshift; Positions=418, 464; Evidence={ECO:0000305}; Sequence=CAI13622.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14512.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC25A24 Gene

    Alternative splice isoforms for SLC25A24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A24 Gene

Proteomics data for SLC25A24 Gene at MOPED

Post-translational modifications for SLC25A24 Gene

  • Ubiquitination at Lys62
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A24 Gene

No data available for DME Specific Peptides for SLC25A24 Gene

Domains for SLC25A24 Gene

Gene Families for SLC25A24 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • SLC :Solute carriers
IUPHAR :

Suggested Antigen Peptide Sequences for SLC25A24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NUK1

UniProtKB/Swiss-Prot:

SCMC1_HUMAN :
  • Q6NUK1
Domain:
  • The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (PubMed:24332718).
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A24: view

Function for SLC25A24 Gene

Molecular function for SLC25A24 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.97 mM for AMP {ECO:0000269 PubMed:15123600}; KM=0.3 mM for ADP {ECO:0000269 PubMed:15123600}; KM=0.33 mM for ATP {ECO:0000269 PubMed:15123600}; KM=0.2 mM for ATP-Mg {ECO:0000269 PubMed:15123600}; KM=1.64 mM for Pi {ECO:0000269 PubMed:15123600}; Vmax=337 umol/min/g enzyme with AMP as substrate {ECO:0000269 PubMed:15123600}; Vmax=345 umol/min/g enzyme with ADP as substrate {ECO:0000269 PubMed:15123600}; Vmax=320 umol/min/g enzyme with ATP as substrate {ECO:0000269 PubMed:15123600}; Vmax=365 umol/min/g enzyme with ATP-Mg as substrate {ECO:0000269 PubMed:15123600}; Vmax=380 umol/min/g enzyme with Pi as substrate {ECO:0000269 PubMed:15123600};
UniProtKB/Swiss-Prot Function: Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.

Gene Ontology (GO) - Molecular Function for SLC25A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005347 ATP transmembrane transporter activity IMP 22015608
GO:0005509 calcium ion binding IDA 24332718
genes like me logo Genes that share ontologies with SLC25A24: view

miRNA for SLC25A24 Gene

miRTarBase miRNAs that target SLC25A24

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A24 Gene

Localization for SLC25A24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A24 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A24 Gene COMPARTMENTS Subcellular localization image for SLC25A24 gene
Compartment Confidence
mitochondrion 5
cytosol 3
peroxisome 2
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC25A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IDA 24332718
genes like me logo Genes that share ontologies with SLC25A24: view

Pathways for SLC25A24 Gene

SuperPathways for SLC25A24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006839 mitochondrial transport IMP 22015608
GO:0010941 regulation of cell death IMP 22015608
GO:0015867 ATP transport IMP 22015608
GO:0034599 cellular response to oxidative stress IMP 22015608
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A24: view

No data available for Pathways by source for SLC25A24 Gene

Compounds for SLC25A24 Gene

(1) HMDB Compounds for SLC25A24 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SLC25A24: view

Transcripts for SLC25A24 Gene

mRNA/cDNA for SLC25A24 Gene

Unigene Clusters for SLC25A24 Gene

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A24 Gene

No ASD Table

Relevant External Links for SLC25A24 Gene

GeneLoc Exon Structure for
SLC25A24
ECgene alternative splicing isoforms for
SLC25A24

Expression for SLC25A24 Gene

mRNA expression in normal human tissues for SLC25A24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A24 Gene

SOURCE GeneReport for Unigene cluster for SLC25A24 Gene Hs.656870

mRNA Expression by UniProt/SwissProt for SLC25A24 Gene

Q6NUK1-SCMC1_HUMAN
Tissue specificity: Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart.
genes like me logo Genes that share expressions with SLC25A24: view

No data available for mRNA differential expression in normal tissues for SLC25A24 Gene

Orthologs for SLC25A24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A24 35
  • 99.72 (n)
  • 99.58 (a)
SLC25A24 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC534742 35
  • 91.68 (n)
  • 94.76 (a)
SLC25A24 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A24 35
  • 91.35 (n)
  • 91.59 (a)
SLC25A24 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a24 35
  • 87.37 (n)
  • 93.68 (a)
Slc25a24 16
Slc25a24 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A24 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A24 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a24 35
  • 86.88 (n)
  • 92.84 (a)
chicken
(Gallus gallus)
Aves SLC25A24 35
  • 77.46 (n)
  • 79.62 (a)
SLC25A24 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398474 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a24 35
  • 70.68 (n)
  • 72.73 (a)
zebrafish
(Danio rerio)
Actinopterygii SLC25A24 36
  • 65 (a)
OneToOne
zgc:92470 35
  • 65.41 (n)
  • 65.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32103 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F17E5.2 36
  • 40 (a)
ManyToMany
F55A11.4 36
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51050 35
  • 49.96 (n)
  • 43.18 (a)
rice
(Oryza sativa)
Liliopsida Os.26881 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01564 35
  • 47.03 (n)
  • 40.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12D12.05c 35
  • 50.46 (n)
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5381 36
  • 43 (a)
OneToMany
Species with no ortholog for SLC25A24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A24 Gene

ENSEMBL:
Gene Tree for SLC25A24 (if available)
TreeFam:
Gene Tree for SLC25A24 (if available)

Paralogs for SLC25A24 Gene

Paralogs for SLC25A24 Gene

Selected SIMAP similar genes for SLC25A24 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC25A24 Gene

genes like me logo Genes that share paralogs with SLC25A24: view

Variants for SLC25A24 Gene

Sequence variations from dbSNP and Humsavar for SLC25A24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs476386 -- 108,194,964(+) TATTA(C/T)ATCCA intron-variant
rs479537 -- 108,175,054(+) cgctg(A/G)gggac intron-variant
rs481267 -- 108,175,198(+) gtcac(A/G)ggagg intron-variant
rs483253 -- 108,175,422(+) aaagt(A/G)agtca intron-variant
rs490680 -- 108,181,896(+) TGCAG(A/G)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A24 Gene

Variant ID Type Subtype PubMed ID
nsv524680 CNV Gain 19592680
dgv83e1 CNV Complex 17122850
nsv428179 CNV Gain 18775914
nsv517978 CNV Loss 19592680
nsv872136 CNV Loss 21882294
nsv508459 CNV Loss 20534489
esv22495 CNV Loss 19812545
dgv84e1 CNV Complex 17122850
esv32800 CNV Loss 17666407
nsv2265 CNV Loss 18451855
esv33273 CNV Gain 17666407
nsv526757 CNV Loss 19592680
esv32547 CNV Gain 17666407
nsv10539 CNV Gain+Loss 18304495
esv2665550 CNV Deletion 23128226
esv2498743 CNV Loss 19546169
esv2623047 CNV Deletion 19546169
nsv820521 CNV Deletion 20802225
nsv823842 CNV Gain 20364138
esv2122744 CNV Deletion 18987734
nsv823853 CNV Loss 20364138
esv3739 CNV Deletion 18987735
dgv5e180 CNV Gain 20482838
dgv62n67 CNV Loss 20364138
esv2715906 CNV Deletion 23290073
esv9427 CNV Loss 19470904
nsv819227 CNV Gain 19587683
nsv498678 CNV Loss 21111241
esv2675031 CNV Deletion 23128226
dgv59e199 CNV Deletion 23128226
esv21858 CNV Gain+Loss 19812545
nsv433387 CNV Loss 18776910
esv2421780 CNV Deletion 20811451
nsv513999 CNV Loss 21397061
nsv442958 CNV CNV 18776908

Relevant External Links for SLC25A24 Gene

HapMap Linkage Disequilibrium report
SLC25A24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A24 Gene

Disorders for SLC25A24 Gene

Relevant External Links for SLC25A24

Genetic Association Database (GAD)
SLC25A24
Human Genome Epidemiology (HuGE) Navigator
SLC25A24
genes like me logo Genes that share disorders with SLC25A24: view

No data available for UniProtKB/Swiss-Prot for SLC25A24 Gene

Publications for SLC25A24 Gene

  1. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. (PMID: 15123600) Fiermonte G. … Palmieri F. (J. Biol. Chem. 2004) 2 3 4
  2. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. (PMID: 15054102) del Arco A. … Satrustegui J. (J. Biol. Chem. 2004) 3 4
  3. SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering. (PMID: 22015608) Traba J. … SatrA_stegui J. (Cell Death Differ. 2012) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for SLC25A24 Gene

Sources for SLC25A24 Gene

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