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Aliases for SLC25A23 Gene

Aliases for SLC25A23 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 23 2 3
  • Mitochondrial Ca(2+)-Dependent Solute Carrier Protein 2 3 4
  • Small Calcium-Binding Mitochondrial Carrier Protein 3 3 4
  • Mitochondrial ATP-Mg/Pi Carrier Protein 2 3 4
  • Solute Carrier Family 25 Member 23 3 4
  • MCSC2 3 4
  • APC2 3 4
  • Calcium-Binding Mitochondrial Carrier Protein SCaMC-3 3
  • Mitochondrial Ca2+-Dependent Solute Carrier Protein 2 3
  • Short Calcium-Binding Mitochondrial Carrier 3 3
  • SCaMC-3 3
  • SCAMC3 4

External Ids for SLC25A23 Gene

Previous GeneCards Identifiers for SLC25A23 Gene

  • GC19M006387
  • GC19M006390
  • GC19M006200

Summaries for SLC25A23 Gene

GeneCards Summary for SLC25A23 Gene

SLC25A23 (Solute Carrier Family 25 (Mitochondrial Carrier; Phosphate Carrier), Member 23) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Pathways in cancer. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SLC25A42.

UniProtKB/Swiss-Prot for SLC25A23 Gene

  • Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A23 Gene

Genomics for SLC25A23 Gene

Regulatory Elements for SLC25A23 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A23 Gene

Start:
6,436,079 bp from pter
End:
6,465,203 bp from pter
Size:
29,125 bases
Orientation:
Minus strand

Genomic View for SLC25A23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A23 Gene

Proteins for SLC25A23 Gene

  • Protein details for SLC25A23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV35-SCMC3_HUMAN
    Recommended name:
    Calcium-binding mitochondrial carrier protein SCaMC-3
    Protein Accession:
    Q9BV35
    Secondary Accessions:
    • B4DGB6
    • Q4LBC2
    • Q705K3
    • Q86Y43
    • Q8N2N4
    • Q96NQ4

    Protein attributes for SLC25A23 Gene

    Size:
    468 amino acids
    Molecular mass:
    52378 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB70825.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11071.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC25A23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A23 Gene

Proteomics data for SLC25A23 Gene at MOPED

Post-translational modifications for SLC25A23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A23 Gene

Domains for SLC25A23 Gene

Gene Families for SLC25A23 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • SLC :Solute carriers
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q9BV35

UniProtKB/Swiss-Prot:

SCMC3_HUMAN :
  • Q9BV35
Domain:
  • Contains 3 EF-hand domains.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A23: view

Function for SLC25A23 Gene

Molecular function for SLC25A23 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.3 mM for AMP {ECO:0000269 PubMed:15123600}; KM=0.54 mM for ADP {ECO:0000269 PubMed:15123600}; KM=0.31 mM for ATP {ECO:0000269 PubMed:15123600}; KM=0.22 mM for ATP-Mg {ECO:0000269 PubMed:15123600}; KM=1.4 mM for Pi {ECO:0000269 PubMed:15123600}; Vmax=68 umol/min/g enzyme with AMP as substrate {ECO:0000269 PubMed:15123600}; Vmax=73 umol/min/g enzyme with ADP as substrate {ECO:0000269 PubMed:15123600}; Vmax=65 umol/min/g enzyme with ATP as substrate {ECO:0000269 PubMed:15123600}; Vmax=79 umol/min/g enzyme with ATP-Mg as substrate {ECO:0000269 PubMed:15123600}; Vmax=70 umol/min/g enzyme with Pi as substrate {ECO:0000269 PubMed:15123600};
UniProtKB/Swiss-Prot Function: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

Gene Ontology (GO) - Molecular Function for SLC25A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SLC25A23: view
genes like me logo Genes that share phenotypes with SLC25A23: view

Animal Models for SLC25A23 Gene

MGI Knock Outs for SLC25A23:

Animal Model Products

CRISPR Products

miRNA for SLC25A23 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC25A23 Gene

Localization for SLC25A23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A23 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A23 Gene COMPARTMENTS Subcellular localization image for SLC25A23 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A23: view

Pathways for SLC25A23 Gene

genes like me logo Genes that share pathways with SLC25A23: view

Pathways by source for SLC25A23 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLC25A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002082 regulation of oxidative phosphorylation IEA --
GO:0043457 regulation of cellular respiration IEA --
GO:0051282 regulation of sequestering of calcium ion IEA --
GO:0051503 adenine nucleotide transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A23: view

Compounds for SLC25A23 Gene

(1) HMDB Compounds for SLC25A23 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SLC25A23: view

Transcripts for SLC25A23 Gene

Unigene Clusters for SLC25A23 Gene

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A23

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC25A23

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A23 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7: -

Relevant External Links for SLC25A23 Gene

GeneLoc Exon Structure for
SLC25A23
ECgene alternative splicing isoforms for
SLC25A23

Expression for SLC25A23 Gene

mRNA expression in normal human tissues for SLC25A23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A23 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (5.0), Brain - Caudate (basal ganglia) (4.5), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A23 Gene

SOURCE GeneReport for Unigene cluster for SLC25A23 Gene Hs.356231

mRNA Expression by UniProt/SwissProt for SLC25A23 Gene

Q9BV35-SCMC3_HUMAN
Tissue specificity: Present in various cell lines (at protein level). Expressed at low levels in most tissues examined, with highest expression in brain, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with SLC25A23: view

In Situ Assay Products

Orthologs for SLC25A23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A23 35
  • 98.43 (n)
  • 98.5 (a)
SLC25A23 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A23 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A23 35
  • 90.46 (n)
  • 95.09 (a)
SLC25A23 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a23 35
  • 85.44 (n)
  • 93.79 (a)
Slc25a23 16
Slc25a23 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A23 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A23 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a23 35
  • 85.51 (n)
  • 94.22 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a23 35
  • 69.35 (n)
  • 73.86 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-196h16.11 36
  • 67 (a)
ManyToMany
si:dkey-204f11.59 35
  • 68.2 (n)
  • 71.05 (a)
si:dkey-204f11.59 36
  • 67 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32103 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F17E5.2 36
  • 42 (a)
ManyToMany
F55A11.4 36
  • 42 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os06g0604500 35
  • 47.78 (n)
  • 42.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5381 36
  • 42 (a)
OneToMany
Species with no ortholog for SLC25A23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A23 Gene

ENSEMBL:
Gene Tree for SLC25A23 (if available)
TreeFam:
Gene Tree for SLC25A23 (if available)

Paralogs for SLC25A23 Gene

Paralogs for SLC25A23 Gene

genes like me logo Genes that share paralogs with SLC25A23: view

Variants for SLC25A23 Gene

Sequence variations from dbSNP and Humsavar for SLC25A23 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs168348 -- 6,461,740(+) TCACT(C/T)GTCAC upstream-variant-2KB
rs173229 -- 6,452,294(+) AGAGG(A/G)ACGCG intron-variant
rs173230 -- 6,457,152(+) cctcc(A/G)cctct intron-variant
rs186996 -- 6,446,655(+) atgtc(C/T)tatgc intron-variant
rs187010 -- 6,448,761(+) actgc(A/G)cctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A23 Gene

Variant ID Type Subtype PubMed ID
dgv3698n71 CNV Loss 21882294
nsv910916 CNV Loss 21882294
nsv833727 CNV Loss 17160897
nsv910923 CNV Loss 21882294
esv2718065 CNV Deletion 23290073
esv2017710 CNV Deletion 18987734

Relevant External Links for SLC25A23 Gene

HapMap Linkage Disequilibrium report
SLC25A23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A23 Gene

Disorders for SLC25A23 Gene

Relevant External Links for SLC25A23

Genetic Association Database (GAD)
SLC25A23
Human Genome Epidemiology (HuGE) Navigator
SLC25A23
genes like me logo Genes that share disorders with SLC25A23: view

No data available for UniProtKB/Swiss-Prot for SLC25A23 Gene

Publications for SLC25A23 Gene

  1. Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. (PMID: 15716113) Bassi M.T. … Borsani G. (Gene 2005) 3 4 23
  2. Novel variants of human SCaMC-3, an isoform of the ATP-Mg/P(i) mitochondrial carrier, generated by alternative splicing from 3'- flanking transposable elements. (PMID: 15801905) Del Arco A. (Biochem. J. 2005) 3 4 23
  3. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. (PMID: 15123600) Fiermonte G. … Palmieri F. (J. Biol. Chem. 2004) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. (PMID: 15054102) del Arco A. … Satrustegui J. (J. Biol. Chem. 2004) 3 4

Products for SLC25A23 Gene

Sources for SLC25A23 Gene

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