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Aliases for SLC25A22 Gene

Aliases for SLC25A22 Gene

  • Solute Carrier Family 25 Member 22 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier: Glutamate), Member 22 2 3 5
  • Glutamate/H(+) Symporter 1 3 4
  • GC-1 3 4
  • GC1 3 4
  • EIEE3 3
  • NET44 3

External Ids for SLC25A22 Gene

Previous GeneCards Identifiers for SLC25A22 Gene

  • GC11P000747
  • GC11P000400
  • GC11M000783
  • GC11M000784
  • GC11M000785
  • GC11M000608

Summaries for SLC25A22 Gene

Entrez Gene Summary for SLC25A22 Gene

  • This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010]

GeneCards Summary for SLC25A22 Gene

SLC25A22 (Solute Carrier Family 25 Member 22) is a Protein Coding gene. Diseases associated with SLC25A22 include Epileptic Encephalopathy, Early Infantile, 3 and Early Myoclonic Encephalopathy. GO annotations related to this gene include symporter activity and L-glutamate transmembrane transporter activity. An important paralog of this gene is SLC25A13.

UniProtKB/Swiss-Prot for SLC25A22 Gene

  • Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A22 Gene

Genomics for SLC25A22 Gene

Regulatory Elements for SLC25A22 Gene

Enhancers for SLC25A22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A22 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A22 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A22 Gene

790,475 bp from pter
798,333 bp from pter
7,859 bases
Minus strand

Genomic View for SLC25A22 Gene

Genes around SLC25A22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A22 Gene

Proteins for SLC25A22 Gene

  • Protein details for SLC25A22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial glutamate carrier 1
    Protein Accession:
    Secondary Accessions:
    • A8K366
    • C9J1H6
    • E9PJD3
    • E9PKB2
    • E9PL68
    • E9PN26
    • E9PNQ3
    • E9PP01
    • E9PR97
    • Q8TBU8

    Protein attributes for SLC25A22 Gene

    323 amino acids
    Molecular mass:
    34470 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH24212.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC25A22 Gene

Proteomics data for SLC25A22 Gene at MOPED

Post-translational modifications for SLC25A22 Gene

  • Ubiquitination at Lys 55, Lys 96, Lys 142, Lys 188, and Lys 286
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SLC25A22 Gene

Domains & Families for SLC25A22 Gene

Gene Families for SLC25A22 Gene

Protein Domains for SLC25A22 Gene

Suggested Antigen Peptide Sequences for SLC25A22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A22: view

Function for SLC25A22 Gene

Molecular function for SLC25A22 Gene

UniProtKB/Swiss-Prot Function:
Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).
genes like me logo Genes that share phenotypes with SLC25A22: view

Human Phenotype Ontology for SLC25A22 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A22

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A22 Gene

Localization for SLC25A22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A22 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A22 Gene COMPARTMENTS Subcellular localization image for SLC25A22 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SLC25A22: view

Pathways & Interactions for SLC25A22 Gene

SuperPathways for SLC25A22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0055085 transmembrane transport IEA --
GO:0089711 L-glutamate transmembrane transport IDA 11897791
genes like me logo Genes that share ontologies with SLC25A22: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A22 Gene

Drugs & Compounds for SLC25A22 Gene

(1) Drugs for SLC25A22 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with SLC25A22: view

Transcripts for SLC25A22 Gene

Unigene Clusters for SLC25A22 Gene

Solute carrier family 25 (mitochondrial carrier: glutamate), member 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A22 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for SLC25A22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A22 Gene

mRNA expression in normal human tissues for SLC25A22 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A22 Gene

This gene is overexpressed in Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for SLC25A22 Gene

This gene is overexpressed in Nasal epithelium (21.5), Brain (20.0), and Retina (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A22 Gene

SOURCE GeneReport for Unigene cluster for SLC25A22 Gene Hs.99486

mRNA Expression by UniProt/SwissProt for SLC25A22 Gene

Tissue specificity: Highly expressed in most tissues.
genes like me logo Genes that share expression patterns with SLC25A22: view

Protein tissue co-expression partners for SLC25A22 Gene

- Elite partner

Primer Products

Orthologs for SLC25A22 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC25A22 35
  • 88.85 (n)
  • 94.01 (a)
SLC25A22 36
  • 93 (a)
(Mus musculus)
Mammalia Slc25a22 35
  • 88.24 (n)
  • 95.67 (a)
Slc25a22 16
Slc25a22 36
  • 96 (a)
(Pan troglodytes)
Mammalia SLC25A22 35
  • 99.15 (n)
  • 98.88 (a)
(Rattus norvegicus)
Mammalia LOC100911440 35
  • 88.13 (n)
  • 94.74 (a)
(Gallus gallus)
Aves SLC25A22 35
  • 78.47 (n)
  • 86.52 (a)
SLC25A22 36
  • 82 (a)
(Anolis carolinensis)
Reptilia SLC25A22 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488953 35
  • 73.61 (n)
  • 84.62 (a)
Str.12092 35
(Danio rerio)
Actinopterygii LOC571044 35
  • 73.66 (n)
  • 82.95 (a)
wufa12h05 35
SLC25A22 (1 of 2) 36
  • 76 (a)
SLC25A22 (2 of 2) 36
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8623 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010293 35
  • 56.84 (n)
  • 62.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18347 35
  • 65.32 (n)
  • 63.18 (a)
CG12201 36
  • 52 (a)
CG18347 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea CELE_F20D1.9 35
  • 55.56 (n)
  • 56.38 (a)
F20D1.9 36
  • 51 (a)
F55G1.5 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGC1 36
  • 13 (a)
Species with no ortholog for SLC25A22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A22 Gene

Gene Tree for SLC25A22 (if available)
Gene Tree for SLC25A22 (if available)

Paralogs for SLC25A22 Gene

Paralogs for SLC25A22 Gene

genes like me logo Genes that share paralogs with SLC25A22: view

Variants for SLC25A22 Gene

Sequence variations from dbSNP and Humsavar for SLC25A22 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_022737 Epileptic encephalopathy, early infantile, 3 (EIEE3)
rs11549717 -- 792,644(-) CTGCC(C/T)CTCGG reference, missense
rs61876731 -- 795,310(+) AGCGG(A/G)AGGCA intron-variant
rs71022975 -- 794,694(+) CAGGG(-/G)TGGGG intron-variant
rs113091974 -- 792,860(+) TCCCC(A/C)CGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A22 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
nsv896583 CNV Gain 21882294
dgv946n71 CNV Loss 21882294
nsv896587 CNV Loss 21882294
essv11734 CNV CNV 17122850
nsv8759 CNV Gain 18304495
dgv947n71 CNV Loss 21882294
dgv948n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294

Variation tolerance for SLC25A22 Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A22 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A22 Gene

Disorders for SLC25A22 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC25A22 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 3
  • eiee3
early myoclonic encephalopathy
  • epileptic seizures - myoclonic
ohtahara syndrome
  • epileptic encephalopathy, early infantile, 15
malignant migrating partial seizures of infancy
  • epileptic encephalopathy, early infantile, 14
persistent vegetative state
- elite association - COSMIC cancer census association via MalaCards


  • Epileptic encephalopathy, early infantile, 3 (EIEE3) [MIM:609304]: A severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Epileptic encephalopathy early infantile type 3 is characterized by a very early onset, erratic and fragmentary myoclonus, massive myoclonus, partial motor seizures and late tonic spasms. The prognosis is poor, with no effective treatment, and children with the condition either die within 1 to 2 years after birth or survive in a persistent vegetative state. {ECO:0000269 PubMed:15592994}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC25A22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC25A22: view

No data available for Genatlas for SLC25A22 Gene

Publications for SLC25A22 Gene

  1. Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. (PMID: 11897791) Fiermonte G. … Walker J.E. (J. Biol. Chem. 2002) 2 3 4 67
  2. Mutations in the mitochondrial glutamate carrier SLC25A22 in neonatal epileptic encephalopathy with suppression bursts. (PMID: 19780765) Molinari F. … Colleaux L. (Clin. Genet. 2009) 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for SLC25A22 Gene

Sources for SLC25A22 Gene