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Aliases for SLC25A21 Gene

Aliases for SLC25A21 Gene

  • Solute Carrier Family 25 Member 21 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Oxodicarboxylate Carrier), Member 21 2 3
  • Solute Carrier Family 25 (Mitochondrial Oxoadipate Carrier), Member 21 2 3
  • ODC 3 4
  • Mitochondrial 2-Oxodicarboxylate Carrier 3
  • Oxodicarboxylate Carrier 3
  • ODC1 3

External Ids for SLC25A21 Gene

Previous GeneCards Identifiers for SLC25A21 Gene

  • GC14M034529
  • GC14M031006
  • GC14M035139
  • GC14M036218
  • GC14M037148
  • GC14M017261

Summaries for SLC25A21 Gene

Entrez Gene Summary for SLC25A21 Gene

  • SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC25A21 Gene

SLC25A21 (Solute Carrier Family 25 Member 21) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism.

UniProtKB/Swiss-Prot for SLC25A21 Gene

  • Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

Gene Wiki entry for SLC25A21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A21 Gene

Genomics for SLC25A21 Gene

Regulatory Elements for SLC25A21 Gene

Enhancers for SLC25A21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G036975 1.3 FANTOM5 ENCODE 6.8 +196.4 196388 1.6 PKNOX1 FOXA2 CREB3L1 ARNT TCF12 GATA2 ELK1 FOS NCOA1 ZNF592 MIPOL1 NKX2-8 SLC25A21 GC14P036975 GC14P037020
GH14G036995 0.6 FANTOM5 12.9 +176.7 176732 0.3 KLF16 RFXANK TAL1 HMBOX1 ZNF652 YY1 MIPOL1 NKX2-8 SLC25A21 GC14P036975 GC14P037020
GH14G036848 0.7 FANTOM5 9.9 +324.5 324548 0.4 HDAC1 TBP PKNOX1 ZNF837 GFI1B CEBPB YBX1 CEBPG IRF9 ZSCAN21 MIPOL1 NKX2-8 SLC25A21 ENSG00000258601 MIR4503
GH14G037000 0.4 FANTOM5 13.8 +172.2 172207 0.3 NBN FOXP1 MIPOL1 NKX2-8 SLC25A21 GC14P037020 GC14P036975
GH14G037116 1 ENCODE 5.2 +55.7 55657 2.2 PKNOX1 FOXA2 ARNT DMAP1 FEZF1 YY1 FOS ZNF202 SP5 MXD4 SLC25A21-AS1 SLC25A21 GC14P037106
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A21 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067760 465 1600 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for SLC25A21 Gene

Chromosome:
14
Start:
36,677,318 bp from pter
End:
37,172,866 bp from pter
Size:
495,549 bases
Orientation:
Minus strand

Genomic View for SLC25A21 Gene

Genes around SLC25A21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A21 Gene

Proteins for SLC25A21 Gene

  • Protein details for SLC25A21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQT8-ODC_HUMAN
    Recommended name:
    Mitochondrial 2-oxodicarboxylate carrier
    Protein Accession:
    Q9BQT8
    Secondary Accessions:
    • A8K0L0
    • G3V4L5
    • Q3MJ99

    Protein attributes for SLC25A21 Gene

    Size:
    299 amino acids
    Molecular mass:
    33303 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A21 Gene

Post-translational modifications for SLC25A21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A21 Gene

No data available for DME Specific Peptides for SLC25A21 Gene

Domains & Families for SLC25A21 Gene

Gene Families for SLC25A21 Gene

Protein Domains for SLC25A21 Gene

Suggested Antigen Peptide Sequences for SLC25A21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQT8

UniProtKB/Swiss-Prot:

ODC_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A21: view

Function for SLC25A21 Gene

Molecular function for SLC25A21 Gene

UniProtKB/Swiss-Prot Function:
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

Gene Ontology (GO) - Molecular Function for SLC25A21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005310 dicarboxylic acid transmembrane transporter activity IBA --
GO:0015139 alpha-ketoglutarate transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC25A21: view
genes like me logo Genes that share phenotypes with SLC25A21: view

Animal Models for SLC25A21 Gene

MGI Knock Outs for SLC25A21:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC25A21 Gene

Localization for SLC25A21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A21 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A21 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with SLC25A21: view

Pathways & Interactions for SLC25A21 Gene

genes like me logo Genes that share pathways with SLC25A21: view

Gene Ontology (GO) - Biological Process for SLC25A21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006554 lysine catabolic process TAS --
GO:0006810 transport IEA --
GO:0006835 dicarboxylic acid transport IBA --
GO:0006839 mitochondrial transport IBA --
GO:0015742 alpha-ketoglutarate transport IEA --
genes like me logo Genes that share ontologies with SLC25A21: view

No data available for SIGNOR curated interactions for SLC25A21 Gene

Drugs & Compounds for SLC25A21 Gene

(1) Additional Compounds for SLC25A21 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A21: view

Transcripts for SLC25A21 Gene

Unigene Clusters for SLC25A21 Gene

Solute carrier family 25 (mitochondrial oxoadipate carrier), member 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2:

Relevant External Links for SLC25A21 Gene

GeneLoc Exon Structure for
SLC25A21
ECgene alternative splicing isoforms for
SLC25A21

Expression for SLC25A21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A21 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A21 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for SLC25A21 Gene

This gene is overexpressed in Testis (10.8), Skin (9.9), and Plasma (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A21 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC25A21 Gene:

SLC25A21

SOURCE GeneReport for Unigene cluster for SLC25A21 Gene:

Hs.730857

mRNA Expression by UniProt/SwissProt for SLC25A21 Gene:

Q9BQT8-ODC_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SLC25A21 Gene

  • Liver(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC25A21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A21 Gene

Orthologs for SLC25A21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A21 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia SLC25A21 34 35
  • 92.42 (n)
cow
(Bos Taurus)
Mammalia SLC25A21 34 35
  • 89.89 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a21 34
  • 84.45 (n)
mouse
(Mus musculus)
Mammalia Slc25a21 34 16 35
  • 83.67 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A21 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A21 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A21 34 35
  • 80.05 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A21 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a21 34
  • 71.79 (n)
Str.17900 34
zebrafish
(Danio rerio)
Actinopterygii slc25a21 34 35
  • 70.02 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002939 34
  • 61.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5254 34 35
  • 59.11 (n)
EG:BACR19J1.2 36
  • 57 (a)
CG9582 36 35
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea R11.1 36 34 35
  • 60.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ODC2 34 35 37
  • 50.88 (n)
ODC1 35
  • 33 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07073g 34
  • 50.44 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR109W 34
  • 47.57 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC328.09 34
  • 49.75 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04837 34
  • 47.48 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7287 34
Species where no ortholog for SLC25A21 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A21 Gene

ENSEMBL:
Gene Tree for SLC25A21 (if available)
TreeFam:
Gene Tree for SLC25A21 (if available)

Paralogs for SLC25A21 Gene

(3) SIMAP similar genes for SLC25A21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A21: view

No data available for Paralogs for SLC25A21 Gene

Variants for SLC25A21 Gene

Sequence variations from dbSNP and Humsavar for SLC25A21 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs886050495 Uncertain significance 36,677,503(+) ATGTT(G/T)TGCAA downstream-variant-500B, utr-variant-3-prime
rs1000021322 -- 37,133,986(+) AACTG(G/T)CAACT intron-variant
rs1000024470 -- 37,156,794(+) GACTA(G/T)ATCTA intron-variant
rs1000027869 -- 36,935,598(+) CTGAC(C/G)AATTC intron-variant
rs1000028926 -- 36,980,212(+) TCTGA(C/T)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A21 Gene

Variant ID Type Subtype PubMed ID
dgv1870n100 CNV loss 25217958
dgv1871n100 CNV gain 25217958
esv2669967 CNV deletion 23128226
esv2670122 CNV deletion 23128226
esv2748604 CNV deletion 23290073
esv2748605 CNV deletion 23290073
esv2748606 CNV deletion 23290073
esv275403 CNV loss 21479260
esv28302 CNV loss 19812545
esv3302679 CNV tandem duplication 20981092
esv3343084 CNV duplication 20981092
esv3551386 CNV deletion 23714750
esv3581120 CNV loss 25503493
esv3581121 CNV loss 25503493
esv3584271 CNV gain 25503493
esv3634077 CNV loss 21293372
esv3634079 CNV loss 21293372
esv3634080 CNV loss 21293372
esv3634082 CNV loss 21293372
esv3634083 CNV loss 21293372
esv3634084 CNV loss 21293372
nsv1116740 CNV tandem duplication 24896259
nsv1152919 CNV insertion 26484159
nsv1153559 CNV deletion 26484159
nsv1244 CNV insertion 18451855
nsv473147 CNV novel sequence insertion 20440878
nsv478224 CNV novel sequence insertion 20440878
nsv478449 CNV novel sequence insertion 20440878
nsv507743 OTHER sequence alteration 20534489
nsv507744 OTHER sequence alteration 20534489
nsv511032 OTHER complex 20534489
nsv523551 CNV loss 19592680
nsv526786 CNV loss 19592680
nsv564347 CNV loss 21841781
nsv564348 CNV loss 21841781

Variation tolerance for SLC25A21 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A21 Gene

Human Gene Mutation Database (HGMD)
SLC25A21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A21 Gene

Disorders for SLC25A21 Gene

Relevant External Links for SLC25A21

Genetic Association Database (GAD)
SLC25A21
Human Genome Epidemiology (HuGE) Navigator
SLC25A21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A21

No disorders were found for SLC25A21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A21 Gene

Publications for SLC25A21 Gene

  1. Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location. (PMID: 11083877) Fiermonte G. … Walker J.E. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for SLC25A21 Gene

Sources for SLC25A21 Gene

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