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SLC25A21 Gene

protein-coding   GIFtS: 53
GCID: GC14M037148

Solute Carrier Family 25 (Mitochondrial Oxoadipate Carrier),...

(Previous names: solute carrier family 25 (mitochondrial oxodicarboxylate...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25 (Mitochondrial Oxoadipate Carrier), Member
211 2
     ODC12
ODC2 3 5     Mitochondrial 2-Oxodicarboxylate Carrier2
Solute Carrier Family 25 (Mitochondrial Oxodicarboxylate Carrier), Member
211 2
     Oxodicarboxylate Carrier2
Solute Carrier Family 25 Member 212 3     

External Ids:    HGNC: 144111   Entrez Gene: 898742   Ensembl: ENSG000001830327   OMIM: 6075715   UniProtKB: Q9BQT83   

Export aliases for SLC25A21 gene to outside databases

Previous GC identifers: GC14M034529 GC14M031006 GC14M035139 GC14M036218 GC14M017261


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A21 Gene:
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7
oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a
common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria,
2-oxoadipate is converted into acetyl-CoA.(supplied by OMIM, Apr 2004)

GeneCards Summary for SLC25A21 Gene:
SLC25A21 (solute carrier family 25 (mitochondrial oxoadipate carrier), member 21) is a protein-coding gene. Diseases associated with SLC25A21 include breast cancer, and malaria.

UniProtKB/Swiss-Prot: ODC_HUMAN, Q9BQT8
Function: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport
2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate,
2-aminoadipate, oxaloacetate, and citrate

Gene Wiki entry for SLC25A21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A21 gene promoter:
         Sox5   Pbx1a   Nkx6-1   AP-1   ATF-2   c-Jun   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A21 promoter sequence
   Search Chromatin IP Primers for SLC25A21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q13.3   HGNC cytogenetic band: 14q13.3

SLC25A21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A21 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M037148:  view genomic region     (about GC identifiers)

Start:
37,147,126 bp from pter      End:
37,642,071 bp from pter
Size:
494,946 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ODC_HUMAN, Q9BQT8 (See protein sequence)
Recommended Name: Mitochondrial 2-oxodicarboxylate carrier  
Size: 299 amino acids; 33303 Da
Secondary accessions: A8K0L0 G3V4L5 Q3MJ99
Alternative splicing: 2 isoforms:  Q9BQT8-1   Q9BQT8-2   

Explore the universe of human proteins at neXtProt for SLC25A21: NX_Q9BQT8

Explore proteomics data for SLC25A21 at MOPED


See SLC25A21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001164641.1  NP_085134.1  

ENSEMBL proteins: 
 ENSP00000451873   ENSP00000329452  
Reactome Protein details: Q9BQT8

SLC25A21 Human Recombinant Protein Products:

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Novus Biologicals SLC25A21 Lysate
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Cloud-Clone Corp. Proteins for SLC25A21

SLC25A21 Antibody Products:

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LSBio Antibodies in human, mouse, rat for SLC25A21

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Cloud-Clone Corp. ELISAs for SLC25A21
Cloud-Clone Corp. CLIAs for SLC25A21


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial oxodicarboxylate carrier
Mitochondrial di- and tri-carboxylic acid transporters

3 InterPro protein domains:
 IPR002067 Mit_carrier
 IPR023395 Mt_carrier_dom
 IPR018108 Mitochondrial_sb/sol_carrier

Graphical View of Domain Structure for InterPro Entry Q9BQT8

ProtoNet protein and cluster: Q9BQT8

UniProtKB/Swiss-Prot: ODC_HUMAN, Q9BQT8
Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
Similarity: Contains 3 Solcar repeats


SLC25A21 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ODC_HUMAN, Q9BQT8
Function: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport
2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate,
2-aminoadipate, oxaloacetate, and citrate

Phenotypes:
     9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc25a21):

 adipose tissue  behavior/neurological  craniofacial  growth/size/body  hearing/vestibular/ear 
 hematopoietic system  homeostasis/metabolism  limbs/digits/tail  skeleton 

SLC25A21 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A21
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC25A21

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC25A21
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC25A21

miRNA
Products:
    
miRTarBase miRNAs that target SLC25A21:
hsa-mir-15a-5p (MIRT051317), hsa-mir-192-5p (MIRT004127), hsa-mir-193b-3p (MIRT041549), hsa-mir-100-5p (MIRT048600), hsa-mir-324-3p (MIRT042942)

Block miRNA regulation of human, mouse, rat SLC25A21 using miScript Target Protectors
6 qRT-PCR Assays for microRNAs that regulate SLC25A21:
hsa-miR-1265 hsa-miR-1266 hsa-miR-187* hsa-miR-489 hsa-miR-3918 hsa-let-7f-2*
SwitchGear 3'UTR luciferase reporter plasmidSLC25A21 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SLC25A21

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): SLC25A21 (NM_030631)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A21

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A21


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ODC_HUMAN, Q9BQT8: Mitochondrion inner membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol2
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane TAS--
GO:0016021integral component of membrane IEA--

SLC25A21 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SLC25A21 About    
See pathways by source

SuperPathContained pathways About
1Metabolism of amino acids and derivatives
Lysine catabolism0.00
Metabolism of amino acids and derivatives
2Metabolism
Metabolism0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for SLC25A21
    Lysine catabolism



SLC25A21 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A21: 
          Mitochondria in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for SLC25A21

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for SLC25A21 (Q9BQT83 ENSP000003294524) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
InteractantInteraction Details
GeneCardExternal ID(s)
SLC25A29Q8N8R33, ENSP000003521674I2D: score=1 STRING: ENSP00000352167
PHGDHO431753I2D: score=5 
ADAP008133I2D: score=1 
ATAD2Q6PL183I2D: score=1 
CHMP2AO436333I2D: score=1 
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006554lysine catabolic process TAS--
GO:0034641cellular nitrogen compound metabolic process TAS--
GO:0044281small molecule metabolic process TAS--
GO:0055085transmembrane transport IEA--

SLC25A21 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC25A21 (ODC)

1 Novoseek inferred chemical compound relationship for SLC25A21 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
alpha-ketoglutarate 67.9 2 16600197 (1)



SLC25A21 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SLC25A21 gene (2 alternative transcripts): 
NM_001171170.1  NM_030631.3  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000555449 ENST00000331299(uc021rsf.1 uc001wtz.2) ENST00000556444
ENST00000546428 ENST00000557611
miRNA
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Block miRNA regulation of human, mouse, rat SLC25A21 using miScript Target Protectors
6 qRT-PCR Assays for microRNAs that regulate SLC25A21:
hsa-miR-1265 hsa-miR-1266 hsa-miR-187* hsa-miR-489 hsa-miR-3918 hsa-let-7f-2*
SwitchGear 3'UTR luciferase reporter plasmidSLC25A21 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for SLC25A21
Predesigned siRNA for gene silencing in human, mouse, rat SLC25A21
Clone
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OriGene ORF clones in mouse, rat for SLC25A21
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SLC25A21 (NM_030631)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A21
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A21
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A21
  QuantiTect SYBR Green Assays in human, mouse, rat SLC25A21
  QuantiFast Probe-based Assays in human, mouse, rat SLC25A21

13 AceView cDNA sequences:

AJ278148 NM_030631 BU618605 AA779664 BX482143 CD677090 AI823388 BU175930 
AI208721 BG495541 H70183 CD703751 R29313 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A21    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:              -           -                                                   
SP2:                                                                              


ECgene alternative splicing isoforms for SLC25A21

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC25A21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAATAAAATT
SLC25A21 Expression
About this image

SLC25A21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC25A21 Protein Expression

UniProtKB/Swiss-Prot: ODC_HUMAN, Q9BQT8
Tissue specificity: Ubiquitous

    Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A21: 
          Mitochondria in human mouse rat

Primer
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QuantiFast Probe-based Assays in human, mouse, rat SLC25A21
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A21 gene from Selected species (see all 20)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc25a211 , 5 solute carrier family 25 (mitochondrial oxodicarboxylate more1, 5 83.67(n)1
81.54(a)1
  12 (24.54 cM)5
2175931  NM_172577.31  NP_766165.21 
 567126345 
chicken
(Gallus gallus)
Aves SLC25A211 solute carrier family 25 (mitochondrial oxoadipate more 80.05(n)
84.59(a)
  423330  XM_001233199.3  XP_001233200.2 
lizard
(Anolis carolinensis)
Reptilia SLC25A216
solute carrier family 25 (mitochondrial oxoadipate...
84(a)
1 ↔ 1
1(24880477-25010151)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.179002 Transcribed sequence with moderate similarity to protein more 76.72(n)    BX751246.1 
zebrafish
(Danio rerio)
Actinopterygii slc25a211 solute carrier family 25 (mitochondrial oxodicarboxylate more 70.02(n)
76.85(a)
  767694  NM_001076632.1  NP_001070100.1 
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR19J1.23
CG52541
carrier3
CG52541
57(a)
(best of 2)3
59.11(n)1
59.45(a)1
  1C43
310201  NM_130500.31  NP_569856.21 
worm
(Caenorhabditis elegans)
Secernentea R11.11 , 3 mitochondrial transporter protein3
R11.11
52(a)3
60.19(n)1
59.36(a)1
  X(16220671-16225705)3
1816921  NM_078237.41  NP_510638.21 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ODC2(YOR222W)4
ODC21
Mitochondrial inner membrane transporter, exports 2-oxoadipate more4
ODC21
50.88(n)1
40.6(a)1
  15(758330-759253)4
8543971, 4  NP_014865.11, 4 


ENSEMBL Gene Tree for SLC25A21 (if available)
TreeFam Gene Tree for SLC25A21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC25A21 gene
3 SIMAP similar genes for SLC25A21 using alignment to 1 protein entry:     ODC_HUMAN:
SLC25A1    SLC25A12    SLC25A13

SLC25A21 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC25A21 (see all 9794)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs358562971,2
C--18242636(+) TTTTTT/-TTTTG 2 -- int11Minor allele frequency- -:0.00NA 2
rs1502418821,2
--37147588(+) GGATTA/GTAACT 2 -- ut310--------
rs1895272481,2
--37147684(+) GAGTTC/TCCAGT 2 -- ut310--------
rs339918031,2
C--37147861(+) AAAAA-/ATATTA 2 -- ut31 int10--------
rs1157230191,2
C,F--37147870(+) AATATT/CACTTG 2 -- ut31 int11Minor allele frequency- C:0.03WA 118
rs1995861871,2
C--37147909(+) TTCTT-/TATC  
        
TAAAT
2 -- int1 ut310--------
rs1821866681,2
--37147935(+) TGTTAC/TTGTGC 2 -- ut31 int10--------
rs1379527581,2
--37147940(+) TTGTGC/TTATTT 2 -- ut31 int10--------
rs116221231,2
H--37147961(+) TCTGGT/GTCTTG 2 -- ut31 int14Minor allele frequency- G:0.00NS EA 416
rs116221241,2
H--37147967(+) TCTTGT/GATTTT 2 -- ut31 int14Minor allele frequency- G:0.00NS EA 416

HapMap Linkage Disequilibrium report for SLC25A21 (37147126 - 37397126 bp, first 250kb of SLC25A21)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SLC25A21 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2670122CNV Deletion23128226
esv2748604CNV Deletion23290073
esv2669967CNV Deletion23128226
esv2748606CNV Deletion23290073
esv2748605CNV Deletion23290073
nsv507743CNV Insertion20534489
nsv1244CNV Insertion18451855
nsv507744CNV Insertion20534489
esv275403CNV Loss21479260
nsv523551CNV Loss19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC25A21
DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607571    OMIM disorders: --

2 diseases for SLC25A21:    
About MalaCards
breast cancer    malaria


SLC25A21 for disorders           About GeneDecksing

Genetic Association Database (GAD): SLC25A21
Human Genome Epidemiology (HuGE) Navigator: SLC25A21 (6 documents)

Export disorders for SLC25A21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC25A21 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with SLC25A21)
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  1. Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location. (PubMed id 11083877)1, 2, 3, 9 Fiermonte G.... Walker J.E. (J. Biol. Chem. 2001)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
  8. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (Mol. Aspects Med. 2013)
  9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
  10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89874 HGNC: 14411 AceView: SLC25A21 Ensembl:ENSG00000183032 euGenes: HUgn89874
ECgene: SLC25A21 H-InvDB: SLC25A21

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC25A21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC25A21 gene:
Search GeneIP for patents involving SLC25A21

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