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Aliases for SLC25A2 Gene

Aliases for SLC25A2 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Ornithine Transporter) Member 2 2 3
  • ORNT2 3 4 6
  • Mitochondrial Ornithine Transporter 2 3
  • Solute Carrier Family 25 Member 2 4
  • ORC2 3

External Ids for SLC25A2 Gene

Previous GeneCards Identifiers for SLC25A2 Gene

  • GC05M140665
  • GC05M140710
  • GC05M140662
  • GC05M135827

Summaries for SLC25A2 Gene

Entrez Gene Summary for SLC25A2 Gene

  • This intronless gene encodes a protein that localizes to the mitochondrial inner membrane and likely functions as a transporter of small molecules such as ornithine. This gene is located between the protocadherin beta and gamma gene clusters on chromosome 5. [provided by RefSeq, Dec 2014]

GeneCards Summary for SLC25A2 Gene

SLC25A2 (Solute Carrier Family 25 (Mitochondrial Carrier; Ornithine Transporter) Member 2) is a Protein Coding gene. Diseases associated with SLC25A2 include urea cycle disorder. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include L-ornithine transmembrane transporter activity. An important paralog of this gene is SLC25A15.

UniProtKB/Swiss-Prot for SLC25A2 Gene

  • Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A2 Gene

Genomics for SLC25A2 Gene

Regulatory Elements for SLC25A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A2 Gene

141,302,629 bp from pter
141,304,045 bp from pter
1,417 bases
Minus strand

Genomic View for SLC25A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A2 Gene

Proteins for SLC25A2 Gene

  • Protein details for SLC25A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial ornithine transporter 2
    Protein Accession:
    Secondary Accessions:
    • Q496C1
    • Q6XUI0
    • Q8NFZ2

    Protein attributes for SLC25A2 Gene

    301 amino acids
    Molecular mass:
    32580 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A2 Gene

Proteomics data for SLC25A2 Gene at MOPED

Post-translational modifications for SLC25A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC25A2 Gene

Domains for SLC25A2 Gene

Gene Families for SLC25A2 Gene

Protein Domains for SLC25A2 Gene

Suggested Antigen Peptide Sequences for SLC25A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BXI2
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A2: view

Function for SLC25A2 Gene

Molecular function for SLC25A2 Gene

UniProtKB/Swiss-Prot Function:
Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix

Phenotypes for SLC25A2 Gene

GenomeRNAi human phenotypes for SLC25A2:
genes like me logo Genes that share phenotypes with SLC25A2: view

Animal Model Products

CRISPR Products

miRNA for SLC25A2 Gene

miRTarBase miRNAs that target SLC25A2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A2 Gene

Localization for SLC25A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A2 Gene COMPARTMENTS Subcellular localization image for SLC25A2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC25A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A2: view

Pathways for SLC25A2 Gene

genes like me logo Genes that share pathways with SLC25A2: view

Pathways by source for SLC25A2 Gene

1 Cell Signaling Technology pathway for SLC25A2 Gene
3 BioSystems pathways for SLC25A2 Gene
1 KEGG pathway for SLC25A2 Gene
1 GeneGo (Thomson Reuters) pathway for SLC25A2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC25A2 Gene

Gene Ontology (GO) - Biological Process for SLC25A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000050 urea cycle TAS --
GO:0006810 transport IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SLC25A2: view

Compounds for SLC25A2 Gene

(1) HMDB Compounds for SLC25A2 Gene

Compound Synonyms Cas Number PubMed IDs
  • (+)-S-Ornithine

(1) Drugbank Compounds for SLC25A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • (S)-2,5-Diaminopentanoate
70-26-8 target
genes like me logo Genes that share compounds with SLC25A2: view

Transcripts for SLC25A2 Gene

mRNA/cDNA for SLC25A2 Gene

(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC25A2 Gene

Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A2 Gene

No ASD Table

Relevant External Links for SLC25A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A2 Gene

mRNA expression in normal human tissues for SLC25A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A2 Gene

This gene is overexpressed in Testis (30.7).

SOURCE GeneReport for Unigene cluster for SLC25A2 Gene Hs.97647

mRNA Expression by UniProt/SwissProt for SLC25A2 Gene

Tissue specificity: Expressed in liver, kidney, pancreas and cultured fibroblasts
genes like me logo Genes that share expressions with SLC25A2: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for SLC25A2 Gene

Orthologs for SLC25A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC25A2 35
  • 86.49 (n)
  • 86.71 (a)
(Canis familiaris)
Mammalia LOC102151234 35
  • 86.16 (n)
  • 87.04 (a)
SLC25A2 36
  • 87 (a)
(Pan troglodytes)
Mammalia SLC25A2 35
  • 99.78 (n)
  • 99.67 (a)
(Mus musculus)
Mammalia Slc25a2 16
Slc25a2 36
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
-- 36
  • 81 (a)
(Gallus gallus)
Aves SLC25A15 36
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC108450 35
  • 74.22 (n)
  • 74.33 (a)
(Danio rerio)
Actinopterygii slc25a15b 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1628 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea T10F2.2 36
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORT1 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for SLC25A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A2 Gene

Gene Tree for SLC25A2 (if available)
Gene Tree for SLC25A2 (if available)

Paralogs for SLC25A2 Gene

Paralogs for SLC25A2 Gene

Selected SIMAP similar genes for SLC25A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A2: view

Variants for SLC25A2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A2 Gene

Variant Cys-159 has a reduced ornithine transport activity, while variant Gly-181 has an increased activity

Sequence variations from dbSNP and Humsavar for SLC25A2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3749779 - 141,303,324(-) AGAAG(G/T)ACCGG missense, reference
rs3749780 - 141,303,190(-) GGCTT(A/G/T)TCGTG missense, reference
rs3749781 -- 141,303,107(-) ACCCT(C/T)TTAAG reference, synonymous-codon
rs6870500 -- 141,305,932(+) GCCCA(C/T)GCTCC upstream-variant-2KB
rs7705024 -- 141,305,211(+) ataAA(C/G)TAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A2 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
nsv428127 CNV Loss 18775914
dgv1858e1 CNV Complex 17122850

Relevant External Links for SLC25A2 Gene

HapMap Linkage Disequilibrium report

Disorders for SLC25A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC25A2 Gene in MalaCards »

(1) Diseases for SLC25A2 Gene including...

(1) University of Copenhagen DISEASES for SLC25A2 Gene

Relevant External Links for SLC25A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC25A2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SLC25A2 Gene

Publications for SLC25A2 Gene

  1. Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder. (PMID: 12948741) Camacho J.A. III … Kong J. (Mol. Genet. Metab. 2003) 3 4 25
  2. Mammalian mitochondrial inner membrane cationic and neutral amino acid carriers. (PMID: 11004451) Porter R.K. (Biochim. Biophys. Acta 2000) 2 3
  3. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3 4
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for SLC25A2 Gene

Sources for SLC25A2 Gene

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