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Aliases for SLC25A18 Gene

Aliases for SLC25A18 Gene

  • Solute Carrier Family 25 Member 18 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier), Member 18 2 3
  • Solute Carrier Family 25 (Glutamate Carrier), Member 18 2 3
  • Glutamate/H(+) Symporter 2 3 4
  • GC2 3 4
  • Mitochondrial Glutamate Carrier 2 3
  • GC-2 4

External Ids for SLC25A18 Gene

Previous GeneCards Identifiers for SLC25A18 Gene

  • GC22P014986
  • GC22P016417
  • GC22P016423
  • GC22P018043
  • GC22P001861
  • GC22P017564
  • GC22P017567
  • GC22P017568
  • GC22P017569
  • GC22P017570
  • GC22P017571
  • GC22P017572

Summaries for SLC25A18 Gene

GeneCards Summary for SLC25A18 Gene

SLC25A18 (Solute Carrier Family 25 Member 18) is a Protein Coding gene. Diseases associated with SLC25A18 include Cat Eye Syndrome and Phencyclidine Abuse. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include symporter activity. An important paralog of this gene is SLC25A22.

UniProtKB/Swiss-Prot for SLC25A18 Gene

  • Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).

Additional gene information for SLC25A18 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A18 Gene

Genomics for SLC25A18 Gene

GeneHancer (GH) Regulatory Elements for SLC25A18 Gene

Promoters and enhancers for SLC25A18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I017562 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 572 +0.2 174 2.3 FOXA2 ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 RARA YY1 CREM RXRA SLC25A18 GC22P017566 TPTEP1 BID MICAL3 TMEM121B LOC105372850
GH22I017564 Promoter 0.6 EPDnew 550.8 +1.7 1673 0.1 RNF2 SLC25A18 LOC105372850
GH22I017637 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 +75.9 75873 3.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 BCL2L13 ATP6V1E1 SLC25A18 BID HDHD5-AS1 PIR47030
GH22I017631 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.6 +70.4 70350 3.2 HDGF FOXA2 ARNT TCF12 ARID2 FOS REST ZNF592 ATF4 MAFF BID ATP6V1E1 SLC25A18 ENSG00000236890 BCL2L13 PIR47030
GH22I017528 Enhancer 1 Ensembl ENCODE 11.7 -34.1 -34083 0.8 ELF3 ATF1 ZBTB40 ZNF48 IKZF2 CREM ZHX2 ELF1 NR2F2 SP1 SLC25A18 TPTEP1 DNAJA1P6 PIR55461 CECR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC25A18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC25A18 gene promoter:

Genomic Locations for SLC25A18 Gene

Genomic Locations for SLC25A18 Gene
27,830 bases
Plus strand

Genomic View for SLC25A18 Gene

Genes around SLC25A18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A18 Gene

Proteins for SLC25A18 Gene

  • Protein details for SLC25A18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial glutamate carrier 2
    Protein Accession:

    Protein attributes for SLC25A18 Gene

    315 amino acids
    Molecular mass:
    33849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A18 Gene

Post-translational modifications for SLC25A18 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC25A18 Gene

Domains & Families for SLC25A18 Gene

Gene Families for SLC25A18 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC25A18 Gene

Suggested Antigen Peptide Sequences for SLC25A18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A18: view

Function for SLC25A18 Gene

Molecular function for SLC25A18 Gene

UniProtKB/Swiss-Prot Function:
Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).

Gene Ontology (GO) - Molecular Function for SLC25A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005280 hydrogen:amino acid symporter activity TAS --
GO:0005314 high-affinity glutamate transmembrane transporter activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A18: view
genes like me logo Genes that share phenotypes with SLC25A18: view

Animal Model Products

miRNA for SLC25A18 Gene

miRTarBase miRNAs that target SLC25A18

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A18 Gene

Localization for SLC25A18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A18 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A18 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC25A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC25A18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC25A18 Gene

Pathways & Interactions for SLC25A18 Gene

genes like me logo Genes that share pathways with SLC25A18: view

Gene Ontology (GO) - Biological Process for SLC25A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006839 mitochondrial transport IBA --
GO:0015992 proton transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A18: view

No data available for SIGNOR curated interactions for SLC25A18 Gene

Drugs & Compounds for SLC25A18 Gene

(1) Drugs for SLC25A18 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
genes like me logo Genes that share compounds with SLC25A18: view

Transcripts for SLC25A18 Gene

mRNA/cDNA for SLC25A18 Gene

(16) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC25A18 Gene

Solute carrier family 25 (glutamate carrier), member 18:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A18 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - -
SP10: - - -
SP12: -
SP13: - - -

ExUns: 12a · 12b ^ 13a · 13b
SP1: -
SP2: -

Relevant External Links for SLC25A18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A18 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A18 Gene

This gene is overexpressed in Brain - Amygdala (x5.7), Liver (x5.3), Brain - Caudate (basal ganglia) (x4.7), Brain - Putamen (basal ganglia) (x4.5), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for SLC25A18 Gene

This gene is overexpressed in Brain (27.5), Liver (9.1), Frontal cortex (8.3), and Spinal cord (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A18 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A18 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A18 Gene:


Evidence on tissue expression from TISSUES for SLC25A18 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with SLC25A18: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A18 Gene

Orthologs for SLC25A18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A18 33 34
  • 98.2 (n)
(Canis familiaris)
Mammalia SLC25A18 33 34
  • 87.47 (n)
(Mus musculus)
Mammalia Slc25a18 33 16 34
  • 85.19 (n)
(Rattus norvegicus)
Mammalia Slc25a18 33
  • 85.19 (n)
(Ornithorhynchus anatinus)
Mammalia SLC25A18 34
  • 70 (a)
(Monodelphis domestica)
Mammalia SLC25A18 34
  • 62 (a)
(Anolis carolinensis)
Reptilia SLC25A18 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a18 33
  • 70.21 (n)
(Danio rerio)
Actinopterygii slc25a18 33 34
  • 66.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18347 35 34
  • 51 (a)
CG12201 35 34
  • 47 (a)
(Caenorhabditis elegans)
Secernentea F20D1.9 35 34
  • 48 (a)
F55G1.5 35 34
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGC1 34
  • 12 (a)
Species where no ortholog for SLC25A18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A18 Gene

Gene Tree for SLC25A18 (if available)
Gene Tree for SLC25A18 (if available)

Paralogs for SLC25A18 Gene

Paralogs for SLC25A18 Gene

(3) SIMAP similar genes for SLC25A18 Gene using alignment to 1 proteins: Pseudogenes for SLC25A18 Gene

genes like me logo Genes that share paralogs with SLC25A18: view

Variants for SLC25A18 Gene

Sequence variations from dbSNP and Humsavar for SLC25A18 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000136944 -- 17,574,974(+) T/C intron_variant
rs1000187943 -- 17,567,423(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000208610 -- 17,584,178(+) G/C intron_variant
rs1000222450 -- 17,589,484(+) A/C intron_variant
rs1000307803 -- 17,589,207(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A18 Gene

Variant ID Type Subtype PubMed ID
dgv1278e212 CNV loss 25503493
dgv4464n100 CNV gain 25217958
dgv4465n100 CNV gain 25217958
esv2657458 CNV deletion 23128226
esv2672971 CNV deletion 23128226
esv3568229 CNV loss 25503493
esv3568230 CNV loss 25503493
esv3647223 CNV loss 21293372
esv3647225 CNV loss 21293372
esv3647226 CNV loss 21293372
esv3893428 CNV loss 25118596
nsv1065055 CNV gain 25217958
nsv1116939 CNV deletion 24896259
nsv3553 CNV deletion 18451855
nsv428385 CNV gain+loss 18775914
nsv510802 CNV deletion 20534489
nsv526826 CNV gain 19592680
nsv9871 CNV loss 18304495

Variation tolerance for SLC25A18 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC25A18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A18 Gene

Disorders for SLC25A18 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC25A18 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cat eye syndrome
  • ces
phencyclidine abuse
  • pcp abuse
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC25A18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC25A18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A18 Gene

Publications for SLC25A18 Gene

  1. Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. (PMID: 11897791) Fiermonte G … Walker JE (The Journal of biological chemistry 2002) 2 3 4 58
  2. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. (PMID: 11381032) Footz TK … McDermid HE (Genome research 2001) 2 3 4 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLC25A18 Gene

Sources for SLC25A18 Gene

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