Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC25A18 Gene

Aliases for SLC25A18 Gene

  • Solute Carrier Family 25 Member 18 2 3 4
  • Solute Carrier Family 25 (Glutamate Carrier), Member 18 2 3 5
  • Solute Carrier Family 25 (Mitochondrial Carrier), Member 18 2 3
  • Glutamate/H(+) Symporter 2 3 4
  • GC2 3 4
  • GC-2 4

External Ids for SLC25A18 Gene

Previous GeneCards Identifiers for SLC25A18 Gene

  • GC22P014986
  • GC22P016417
  • GC22P016423
  • GC22P018043
  • GC22P001861
  • GC22P017564
  • GC22P017567

Summaries for SLC25A18 Gene

GeneCards Summary for SLC25A18 Gene

SLC25A18 (Solute Carrier Family 25 Member 18) is a Protein Coding gene. Diseases associated with SLC25A18 include Cat Eye Syndrome. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC25A13.

UniProtKB/Swiss-Prot for SLC25A18 Gene

  • Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A18 Gene

Genomics for SLC25A18 Gene

Regulatory Elements for SLC25A18 Gene

Enhancers for SLC25A18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A18 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A18 Gene

17,563,165 bp from pter
17,590,994 bp from pter
27,830 bases
Plus strand

Genomic View for SLC25A18 Gene

Genes around SLC25A18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A18 Gene

Proteins for SLC25A18 Gene

  • Protein details for SLC25A18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial glutamate carrier 2
    Protein Accession:

    Protein attributes for SLC25A18 Gene

    315 amino acids
    Molecular mass:
    33849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A18 Gene

Proteomics data for SLC25A18 Gene at MOPED

Post-translational modifications for SLC25A18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A18 Gene

Domains & Families for SLC25A18 Gene

Gene Families for SLC25A18 Gene

Protein Domains for SLC25A18 Gene

Suggested Antigen Peptide Sequences for SLC25A18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A18: view

Function for SLC25A18 Gene

Molecular function for SLC25A18 Gene

UniProtKB/Swiss-Prot Function:
Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).
genes like me logo Genes that share phenotypes with SLC25A18: view

Animal Model Products

CRISPR Products

miRNA for SLC25A18 Gene

miRTarBase miRNAs that target SLC25A18

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A18 Gene

Localization for SLC25A18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A18 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A18 Gene COMPARTMENTS Subcellular localization image for SLC25A18 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A18 Gene

Pathways & Interactions for SLC25A18 Gene

SuperPathways for SLC25A18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A18: view

No data available for Pathways by source and SIGNOR curated interactions for SLC25A18 Gene

Drugs & Compounds for SLC25A18 Gene

(1) Drugs for SLC25A18 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with SLC25A18: view

Transcripts for SLC25A18 Gene

Unigene Clusters for SLC25A18 Gene

Solute carrier family 25 (glutamate carrier), member 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A18 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - -
SP10: - - -
SP12: -
SP13: - - -

ExUns: 12a · 12b ^ 13a · 13b
SP1: -
SP2: -

Relevant External Links for SLC25A18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A18 Gene

mRNA expression in normal human tissues for SLC25A18 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A18 Gene

This gene is overexpressed in Brain - Amygdala (x5.7), Liver (x5.3), Brain - Caudate (basal ganglia) (x4.7), Brain - Putamen (basal ganglia) (x4.5), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for SLC25A18 Gene

This gene is overexpressed in Brain (27.5), Liver (9.1), Frontal cortex (8.3), and Spinal cord (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A18 Gene

SOURCE GeneReport for Unigene cluster for SLC25A18 Gene Hs.282982

genes like me logo Genes that share expression patterns with SLC25A18: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC25A18 Gene

Orthologs for SLC25A18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A18 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLC25A18 35
  • 87.47 (n)
  • 92.04 (a)
SLC25A18 36
  • 90 (a)
(Mus musculus)
Mammalia Slc25a18 35
  • 85.19 (n)
  • 87.94 (a)
Slc25a18 16
Slc25a18 36
  • 87 (a)
(Pan troglodytes)
Mammalia SLC25A18 35
  • 98.2 (n)
  • 96.83 (a)
SLC25A18 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Slc25a18 35
  • 85.19 (n)
  • 87.3 (a)
(Monodelphis domestica)
Mammalia SLC25A18 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A18 36
  • 70 (a)
(Anolis carolinensis)
Reptilia SLC25A18 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a18 35
  • 70.21 (n)
  • 75.75 (a)
(Danio rerio)
Actinopterygii slc25a18 35
  • 66.02 (n)
  • 69.58 (a)
slc25a18 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12201 37
  • 47 (a)
CG18347 37
  • 51 (a)
CG12201 36
  • 48 (a)
CG18347 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F20D1.9 37
  • 48 (a)
F55G1.5 37
  • 46 (a)
F20D1.9 36
  • 49 (a)
F55G1.5 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGC1 36
  • 12 (a)
Species with no ortholog for SLC25A18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A18 Gene

Gene Tree for SLC25A18 (if available)
Gene Tree for SLC25A18 (if available)

Paralogs for SLC25A18 Gene

Paralogs for SLC25A18 Gene

(3) SIMAP similar genes for SLC25A18 Gene using alignment to 1 proteins: Pseudogenes for SLC25A18 Gene

genes like me logo Genes that share paralogs with SLC25A18: view

Variants for SLC25A18 Gene

Sequence variations from dbSNP and Humsavar for SLC25A18 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs34134204 -- 17,577,256(+) TGGCC(A/C)TGTGA intron-variant
rs174354 -- 17,561,187(+) ctgcc(C/T)ggccg upstream-variant-2KB
rs174355 -- 17,561,392(+) caccc(C/T)gtccg upstream-variant-2KB
rs174356 -- 17,561,436(+) cagcc(A/G)ccccg upstream-variant-2KB
rs174357 -- 17,562,393(+) gcctc(A/T)gcctc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC25A18 Gene

Variant ID Type Subtype PubMed ID
nsv526826 CNV Gain 19592680
nsv428385 CNV Gain+Loss 18775914
nsv9871 CNV Loss 18304495
nsv510802 CNV Loss 20534489
nsv914150 CNV Loss 21882294
nsv3553 CNV Loss 18451855
esv2029533 CNV Deletion 18987734
esv2723950 CNV Deletion 23290073
esv4931 CNV Deletion 18987735
esv7255 CNV Loss 19470904
esv1371480 CNV Deletion 17803354
esv2672971 CNV Deletion 23128226
nsv511650 CNV Loss 21212237
nsv914151 CNV Gain 21882294
esv2530228 CNV Loss 19546169
nsv436351 CNV Deletion 17901297
esv2533793 CNV Deletion 19546169
esv991669 CNV Deletion 20482838
nsv512645 CNV Loss 21212237
esv2170081 CNV Deletion 18987734
esv2723952 CNV Deletion 23290073
esv2670900 CNV Deletion 23128226
nsv498980 CNV Loss 21111241
esv1116778 CNV Deletion 17803354
nsv828927 CNV Loss 20364138
nsv828928 CNV Loss 20364138
esv23474 CNV Gain 19812545
nsv820867 CNV Deletion 20802225
esv33220 CNV Loss 17666407
esv2657458 CNV Deletion 23128226

Variation tolerance for SLC25A18 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC25A18 Gene

Disorders for SLC25A18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC25A18 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cat eye syndrome
  • ces
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC25A18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A18 Gene

Publications for SLC25A18 Gene

  1. Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. (PMID: 11897791) Fiermonte G. … Walker J.E. (J. Biol. Chem. 2002) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. (PMID: 11381032) Footz T.K. … McDermid H.E. (Genome Res. 2001) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SLC25A18 Gene

Sources for SLC25A18 Gene