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Aliases for SLC25A18 Gene

Aliases for SLC25A18 Gene

  • Solute Carrier Family 25 (Glutamate Carrier), Member 18 2 3
  • GC2 3 4 6
  • Solute Carrier Family 25 (Mitochondrial Carrier), Member 18 2 3
  • Glutamate/H(+) Symporter 2 3 4
  • Solute Carrier Family 25 Member 18 4
  • Mitochondrial Glutamate Carrier 2 3
  • GC-2 4

External Ids for SLC25A18 Gene

Summaries for SLC25A18 Gene

GeneCards Summary for SLC25A18 Gene

SLC25A18 (Solute Carrier Family 25 (Glutamate Carrier), Member 18) is a Protein Coding gene. Diseases associated with SLC25A18 include cat eye syndrome. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC25A13.

UniProtKB/Swiss-Prot for SLC25A18 Gene

  • Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A18 Gene

Genomics for SLC25A18 Gene

Genomic Location for SLC25A18 Gene

Start:
17,563,439 bp from pter
End:
17,590,994 bp from pter
Size:
27,556 bases
Orientation:
Plus strand

Genomic View for SLC25A18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A18 Gene

Regulatory Elements for SLC25A18 Gene

Proteins for SLC25A18 Gene

  • Protein details for SLC25A18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1K4-GHC2_HUMAN
    Recommended name:
    Mitochondrial glutamate carrier 2
    Protein Accession:
    Q9H1K4
    Secondary Accessions:

    Protein attributes for SLC25A18 Gene

    Size:
    315 amino acids
    Molecular mass:
    33849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC25A18 Gene

Proteomics data for SLC25A18 Gene at MOPED

Post-translational modifications for SLC25A18 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys82

Other Protein References for SLC25A18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A18 Gene

Domains for SLC25A18 Gene

Gene Families for SLC25A18 Gene

Protein Domains for SLC25A18 Gene

UniProtKB/Swiss-Prot:

GHC2_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q9H1K4
Similarity:
  • Contains 3 Solcar repeats.:
    • Q9H1K4
genes like me logo Genes that share domains with SLC25A18: view

Function for SLC25A18 Gene

Molecular function for SLC25A18 Gene

UniProtKB/Swiss-Prot Function: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).

Gene Ontology (GO) - Molecular Function for SLC25A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A18: view

Phenotypes for SLC25A18 Gene

GenomeRNAi human phenotypes for SLC25A18:
genes like me logo Genes that share phenotypes with SLC25A18: view

miRNA for SLC25A18 Gene

miRTarBase miRNAs that target SLC25A18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A18 Gene

Localization for SLC25A18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A18 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A18 Gene COMPARTMENTS Subcellular localization image for SLC25A18 gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC25A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A18: view

Pathways for SLC25A18 Gene

SuperPathways for SLC25A18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC25A18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A18: view

No data available for Pathways by source for SLC25A18 Gene

Compounds for SLC25A18 Gene

(1) HMDB Compounds for SLC25A18 Gene

Compound Synonyms Cas Number PubMed IDs
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
56-86-0

(1) Drugbank Compounds for SLC25A18 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
genes like me logo Genes that share compounds with SLC25A18: view

Transcripts for SLC25A18 Gene

Unigene Clusters for SLC25A18 Gene

Solute carrier family 25 (glutamate carrier), member 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A18 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - -
SP10: - - -
SP11:
SP12: -
SP13: - - -

ExUns: 12a · 12b ^ 13a · 13b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SLC25A18 Gene

GeneLoc Exon Structure for
SLC25A18
ECgene alternative splicing isoforms for
SLC25A18

Expression for SLC25A18 Gene

mRNA expression in normal human tissues for SLC25A18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A18 Gene

This gene is overexpressed in Brain - Amygdala (5.7), Liver (5.3), Brain - Caudate (basal ganglia) (4.7), Brain - Putamen (basal ganglia) (4.5), Brain - Nucleus accumbens (basal ganglia) (4.1), and Brain - Hippocampus (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A18 Gene

SOURCE GeneReport for Unigene cluster for SLC25A18 Gene Hs.282982

genes like me logo Genes that share expressions with SLC25A18: view

Orthologs for SLC25A18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A18 36
  • 98.2 (n)
  • 96.83 (a)
SLC25A18 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A18 36
  • 87.47 (n)
  • 92.04 (a)
SLC25A18 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a18 36
  • 85.19 (n)
  • 87.94 (a)
Slc25a18 16
Slc25a18 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A18 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A18 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a18 36
  • 85.19 (n)
  • 87.3 (a)
lizard
(Anolis carolinensis)
Reptilia SLC25A18 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a18 36
  • 70.21 (n)
  • 75.75 (a)
zebrafish
(Danio rerio)
Actinopterygii slc25a18 36
  • 66.02 (n)
  • 69.58 (a)
slc25a18 37
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12201 37
  • 48 (a)
ManyToMany
CG18347 37
  • 52 (a)
ManyToMany
CG12201 38
  • 47 (a)
CG18347 38
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea F20D1.9 37
  • 49 (a)
ManyToMany
F55G1.5 37
  • 48 (a)
ManyToMany
F55G1.5 38
  • 46 (a)
F20D1.9 38
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGC1 37
  • 12 (a)
OneToMany
Species with no ortholog for SLC25A18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A18 Gene

ENSEMBL:
Gene Tree for SLC25A18 (if available)
TreeFam:
Gene Tree for SLC25A18 (if available)

Paralogs for SLC25A18 Gene

Paralogs for SLC25A18 Gene

Selected SIMAP similar genes for SLC25A18 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC25A18 Gene

genes like me logo Genes that share paralogs with SLC25A18: view

Variants for SLC25A18 Gene

Sequence variations from dbSNP and Humsavar for SLC25A18 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs174357 -- 17,562,393(+) gcctc(A/T)gcctc upstream-variant-2KB
rs174358 -- 17,563,390(+) GCAAT(C/G)CCAGC upstream-variant-2KB
rs174359 -- 17,564,372(+) gaagg(G/T)cctag intron-variant
rs174360 -- 17,564,557(+) AAAAA(A/T)TTTTT intron-variant
rs174361 -- 17,564,675(+) gctaa(C/T)gtgaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A18 Gene

Variant ID Type Subtype PubMed ID
nsv526826 CNV Gain 19592680
nsv428385 CNV Gain+Loss 18775914
nsv9871 CNV Loss 18304495
nsv510802 CNV Loss 20534489
nsv914150 CNV Loss 21882294
nsv3553 CNV Loss 18451855
esv2029533 CNV Deletion 18987734
esv2723950 CNV Deletion 23290073
esv4931 CNV Deletion 18987735
esv7255 CNV Loss 19470904
esv1371480 CNV Deletion 17803354
esv2672971 CNV Deletion 23128226
nsv511650 CNV Loss 21212237
nsv914151 CNV Gain 21882294
esv2530228 CNV Loss 19546169
nsv436351 CNV Deletion 17901297
esv2533793 CNV Deletion 19546169
esv991669 CNV Deletion 20482838
nsv512645 CNV Loss 21212237
esv2170081 CNV Deletion 18987734
esv2723952 CNV Deletion 23290073
esv2670900 CNV Deletion 23128226
nsv498980 CNV Loss 21111241
esv1116778 CNV Deletion 17803354
nsv828927 CNV Loss 20364138
nsv828928 CNV Loss 20364138
esv23474 CNV Gain 19812545
nsv820867 CNV Deletion 20802225
esv33220 CNV Loss 17666407
esv2657458 CNV Deletion 23128226

Relevant External Links for SLC25A18 Gene

HapMap Linkage Disequilibrium report
SLC25A18

Disorders for SLC25A18 Gene

(1) MalaCards Diseases for SLC25A18 Gene

Search for SLC25A18 Gene in MalaCards »

Relevant External Links for SLC25A18

Genetic Association Database (GAD)
SLC25A18
Human Genome Epidemiology (HuGE) Navigator
SLC25A18
genes like me logo Genes that share disorders with SLC25A18: view

No data available for UniProtKB/Swiss-Prot for SLC25A18 Gene

Publications for SLC25A18 Gene

  1. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. (PMID: 11381032) Footz T.K. … McDermid H.E. (Genome Res. 2001) 2 3 4
  2. Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. (PMID: 11897791) Fiermonte G. … Walker J.E. (J. Biol. Chem. 2002) 2 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC25A18 Gene

Sources for SLC25A18 Gene

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