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GIFtS

SLC25A17 Gene

protein-coding   GIFtS: 59
GCID: GC22M041165

solute carrier family 25 (mitochondrial carrier; peroxisomal...

(Previous names: solute carrier family 25 (mitochondrial carrier; peroxisomal...)
 Explore 18 diseases affiliated with
SLC25A17 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC25A17    

Aliases
for SLC25A17 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane
Protein, 34kDa), Member 171 2
     Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein,
34kD), Member 171
PMP341 2 3 5     Peroxisomal Membrane Protein (34kD)2
Solute Carrier Family 25 Member 172 3     Peroxisomal Membrane Protein PMP342
34 KDa Peroxisomal Membrane Protein2 3     

External Ids:    HGNC: 109871   Entrez Gene: 104782   Ensembl: ENSG000001003727   OMIM: 6067955   UniProtKB: O438083   

Export aliases for SLC25A17 gene to outside databases

Previous GC identifers: GC22M037780 GC22M039408 GC22M039409 GC22M039490 GC22M024127


Summaries
for SLC25A17 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC25A17:
This gene encodes a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers. It is
expressed in the liver, and is likely involved in transport. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: PM34_HUMAN, O43808
Function: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD),
flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide
adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the
transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism.
Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro

Gene Wiki entry for SLC25A17


Genomic Views
for SLC25A17 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A17 gene promoter:
         NCX/Ncx   Nkx2-5   NF-AT   Evi-1   NF-AT4   NF-AT2   IRF-7A   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC25A17 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

SLC25A17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A17 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041165:  view genomic region     (about GC identifiers)

Start:
 41,165,634 bp from pter      End:
 41,215,403 bp from pter
Size:
 49,770 bases      Orientation:
 minus strand

Proteins
for SLC25A17 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PM34_HUMAN, O43808 (See protein sequence)
Recommended Name: Peroxisomal membrane protein PMP34  
Size: 307 amino acids; 34567 Da
Subunit: Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the
newly synthesized SLC25A17 in the cytosol
Subcellular location: Cytoplasm. Peroxisome membrane; Multi-pass membrane protein
Caution: Was first identified as a peroxisomal ATP transporter (PubMed:12445829). However, later experiments showed
that it acts as a peroxisomal transporter for multiple cofactors (PubMed:22185573)
Secondary accessions: A8KA59 Q5TFL0 Q9UGW8 Q9UGY7

Explore the universe of human proteins at neXtProt for SLC25A17: NX_O43808

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43808

    • SLC25A17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006349.1  
    ENSEMBL proteins: 
     ENSP00000263255   ENSP00000390722   ENSP00000385303   ENSP00000390502   ENSP00000394539  
     ENSP00000407096   ENSP00000416618   ENSP00000387478   ENSP00000414908   ENSP00000400053  
     ENSP00000388966   ENSP00000410565   ENSP00000409781   ENSP00000404200   ENSP00000446471  
     ENSP00000438355  
    Reactome Protein details: O43808
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC25A17 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC25A17

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005743mitochondrial inner membrane ----
    GO:0005777peroxisome IDA9874197
    GO:0005778peroxisomal membrane TAS--
    GO:0005779integral to peroxisomal membrane IDA11121399


    SLC25A17 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC25A17

    Protein Domains /
    Families
    for SLC25A17 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC25A17 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002067 Mit_carrier
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry O43808

    ProtoNet protein and cluster: O43808

    UniProtKB/Swiss-Prot: PM34_HUMAN, O43808
    Domain: The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A
    region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the
    peroxisome-targeting activity
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    Function
    for SLC25A17 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PM34_HUMAN, O43808
    Function: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD),
    flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide
    adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the
    transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism.
    Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro

         Genatlas biochemistry entry for SLC25A17:
    solute carrier protein family 25,member A17,mitochondrial carrier,peroxisomal protein,34kDa,widely expressed

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005347ATP transmembrane transporter activity IGI12445829
    GO:0005515protein binding IPI14709540
    GO:0015217ADP transmembrane transporter activity IDA--
    GO:0015228coenzyme A transmembrane transporter activity IDA--


    SLC25A17 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC25A17:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for SLC25A17 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    2Peroxisome
    		Peroxisome1.00
    3Peroxisomal lipid metabolism
    		Peroxisomal lipid metabolism1.00
    4fatty acid alpha-oxidation II
    		Alpha-oxidation of phytanate0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC25A17
        Alpha-oxidation of phytanate
    Metabolism
    Peroxisomal lipid metabolism
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for SLC25A17):
        Peroxisome


    SLC25A17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC25A17

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC25A17 (O438081, 3 ENSP000003907224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PEX19P408551, 3, ENSP000003570514EBI-594912,EBI-981972 I2D: score=4 STRING: ENSP00000357051
    SLC27A2ENSP000002678424STRING: ENSP00000267842
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001561fatty acid alpha-oxidation TAS--
    GO:0006635fatty acid beta-oxidation IGI12445829
    GO:0006810transport ----
    GO:0006839mitochondrial transport ----
    GO:0015866ADP transport IDA--


    SLC25A17 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC25A17 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC25A17 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC25A17
    3 Novoseek chemical compound relationships for SLC25A17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acyl-coa 69.5 4 10357777 (1), 1468458 (1), 12475388 (1)
    atp 20 5 9425230 (1), 8577752 (1), 7666063 (1), 11248239 (1) (see all 5)
    gold 0 1 1468458 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC25A17 / PM34 

    Transcripts
    for SLC25A17 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC25A17 gene: 
    NM_006358.2  

    Unigene Cluster for SLC25A17:

    Solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
    Hs.474938  [show with all ESTs]
    Unigene Representative Sequence: BC024741
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263255 ENST00000491545(uc010gyg.3) ENST00000435456(uc003azc.3 uc011aou.2 uc003azd.3 uc011aov.2)
    ENST00000402844 ENST00000447566 ENST00000420970 ENST00000430221 ENST00000427084
    ENST00000458600 ENST00000443810 ENST00000412879 ENST00000426396 ENST00000434193
    ENST00000478550 ENST00000449676 ENST00000434185 ENST00000542412 ENST00000544408


    miRNA
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    hsa-miR-579 hsa-miR-3065-5p hsa-miR-3150b-3p hsa-miR-3121-3p hsa-miR-3153 hsa-miR-628-5p hsa-miR-2113 hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC25A17 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK094062.1 AK292924.1 AK298215.1 AK300553.1 BC005957.1 BC012998.2 BC024741.1 BC039064.1 
    BX647991.1 CR456577.1 Y12860.1 

    10 DOTS entries:

    DT.113298  DT.101984188  DT.40131540  DT.100799102  DT.101984187  DT.100808014  DT.120652997  DT.120653029 
    DT.120653039  DT.91764232 

    24/217 AceView cDNA sequences (see all 217):

    BM989309 CR598344 BU627684 BI838245 BX647991 BC012998 BX417089 CF139045 
    AI366781 BM821257 BQ434459 AA678698 AI288460 BM905270 C05876 AA385739 
    CD622459 BM829767 AW182439 BU171732 AA928104 BU730132 NM_006358 AU123445 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A17 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                -     -                       -     -                                                               
    SP2:                                      -                       -     -                                                               
    SP3:                                -     -           -     -     -     -                                                               
    SP4:                                            -     -           -     -                                                               
    SP5:                          -     -     -     -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for SLC25A17

    Expression
    for SLC25A17 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTTTATTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC25A17 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC25A17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC25A17

    SOURCE GeneReport for Unigene cluster: Hs.474938

    UniProtKB/Swiss-Prot: PM34_HUMAN, O43808
    Tissue specificity: Ubiquitous. Expressed in liver

        SABiosciences Expression via Pathway-Focused PCR Array including SLC25A17: 
              Mitochondria in human mouse rat

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    In Situ
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    Orthologs
    for SLC25A17 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A17 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC25A171 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 less 80.78(n)
    89.58(a)    		   418004  XM_416242.3  XP_416242.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC25A176
    		 --
    		 87(a)
    		 1 ↔ 1
    		 5(25955231-25971244)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3981572 peroxisomal membrane protein PMP34 75.08(n)    AJ289240.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CD583726.12   -- 76.7(n)    CD583726.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG322501 CG32250 53.17(n)
    49.83(a)    		   38532  NM_168081.2  NP_728982.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G399706
    PNC26
    (see all 3)    		 peroxisomal adenine nucleotide carrier 2
    (see all 3)    		 26(a)
    25(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2(16683832-16686709)
    5(9714382-9716354)
    rice
    (Oryza sativa)    		 Liliopsida Os09g05089001 hypothetical protein 49.12(n)
    39.3(a)    		   4347528  NM_001070159.1  NP_001063624.1 


    ENSEMBL Gene Tree for SLC25A17 (if available)
    TreeFam Gene Tree for SLC25A17 (if available) 

    Paralogs
    for SLC25A17 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A17 gene
    SLC25A322  
    5 SIMAP similar genes for SLC25A17 using alignment to 13 protein entries:     PM34_HUMAN (see all proteins):
    SLC25A42    SLC25A32    SLC25A1    SLC25A16    SLC25A38

    SLC25A17 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC25A17 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/880 NCBI SNPs in SLC25A17 are shown (see all 880)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1417612101,2
    		--41165137(+) TCAAGG/TTCTGC 1 -- ds50010--------
    rs1900937471,2
    		--41165403(+) ATTTCA/TTTATT 1 -- ds50010--------
    rs1462603091,2
    		--41165449(+) AAACCC/TGCCAT 1 -- ds50010--------
    rs60021191,2
    		--41165460(+) TTTGTC/TATAGG 1 -- ds50010--------
    rs1416276541,2
    		--41165557(+) CCACTC/GCTGGC 1 -- ds50010--------
    rs1825594281,2
    		--41165565(+) GGCCGC/TATAAT 1 -- ds50010--------
    rs412812811,2
    		--41165678(+) TTTGAG/TAAAAA 1 -- ut310--------
    rs1858147581,2
    		--41165741(+) GGGTCC/TTATGG 1 -- ut310--------
    rs1911134471,2
    		--41165778(+) ATCACA/CTGGGA 1 -- ut310--------
    rs1170123451,2
    		C,--41165795(+) AAATAC/TGGAAC 1 -- ut311Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for SLC25A17 (41165634 - 41215403 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC25A17
         1 CNV: 91067

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SLC25A17 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC25A17 for disorders           About GeneDecksing

    OMIM gene information: 606795    OMIM disorders: --

    18 diseases for SLC25A17:    About MalaCards
    peroxisomal biogenesis disorder    peroxisome biogenesis disorders    rhizomelic chondrodysplasia punctata    chondrodysplasia punctata
    infantile refsum disease    adrenomyeloneuropathy    zellweger syndrome    chondrodysplasia
    adrenoleukodystrophy    cystic fibrosis    refsum disease    peroxisomal disease
    protein s deficiency    fibrosis    colon carcinoma    cholesterol
    carcinoma    hepatitis

    4 diseases from the University of Copenhagen DISEASES database for SLC25A17:
    Adrenoleukodystrophy     Zellweger syndrome     Infantile refsum disease     Rhizomelic chondrodysplasia punctata

    7 Novoseek disease relationships for SLC25A17 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zellweger syndrome 92.4 4 10871277 (1), 10942428 (1), 1511694 (1), 8507691 (1)
    adrenoleukodystrophy 92.2 12 14654352 (1), 8577752 (1), 8876235 (1), 11248239 (1) (see all 11)
    peroxisomal disorders 88.9 2 8521871 (1), 11565790 (1)
    demyelinating diseases 38.8 1 8577752 (1)
    glomerulosclerosis 14.3 2 16631601 (1), 12471025 (1)
    tumors 0.753 1 11056045 (1)
    cystic fibrosis 0 1 11056045 (1)


    Export disorders for SLC25A17 gene to outside databases

    Publications
    for SLC25A17 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A17 gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with SLC25A17)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. (PubMed id 9874197)1, 2, 3, 9 Wylin T....Van Veldhoven P.P. (1998)
    2. Topogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments: study using human membrane protein PMP34. (PubMed id 11121399)1, 2, 9 Honsho M. and Fujiki Y. (2001)
    3. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. (PubMed id 10704444)1, 2, 9 Sacksteder K.A.... Gould S.J. (2000)
    4. Identification of human PMP34 as a peroxisomal ATP transporter. (PubMed id 12445829)1, 2, 9 Visser W.F....Wanders R.J. (2002)
    5. Multiple distinct targeting signals in integral peroxisomal membrane proteins. (PubMed id 11402059)1, 2, 9 Jones J.M....Gould S.J. (2001)
    6. The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+. (PubMed id 22185573)1, 2 Agrimi G.... Palmieri F. (2012)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    9. PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. (PubMed id 14709540)1, 2 Jones J.M.... Gould S.J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for SLC25A17 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC25A17 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10478 HGNC: 10987 AceView: SLC25A17 Ensembl:ENSG00000100372 euGenes: HUgn10478
    ECgene: SLC25A17 Kegg: 10478 H-InvDB: SLC25A17

    Other Databases showing SLC25A17 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC25A17 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A17 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC25A17 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC25A17 gene:
    Search GeneIP for patents involving SLC25A17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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