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Aliases for SLC25A17 Gene

Aliases for SLC25A17 Gene

  • Solute Carrier Family 25 Member 17 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kDa), Member 17 2 3
  • PMP34 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier Peroxisomal Membrane Protein, 34kDa), Member 17 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kD), Member 17 2
  • Peroxisomal Membrane Protein (34kD) 2
  • 34 KDa Peroxisomal Membrane Protein 4

External Ids for SLC25A17 Gene

Previous GeneCards Identifiers for SLC25A17 Gene

  • GC22M037780
  • GC22M039408
  • GC22M039409
  • GC22M039490
  • GC22M041165
  • GC22M024127
  • GC22M040771
  • GC22M040772

Summaries for SLC25A17 Gene

Entrez Gene Summary for SLC25A17 Gene

  • This gene encodes a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers. It is expressed in the liver, and is likely involved in transport. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for SLC25A17 Gene

SLC25A17 (Solute Carrier Family 25 Member 17) is a Protein Coding gene. Diseases associated with SLC25A17 include adrenoleukodystrophy and adrenomyeloneuropathy. Among its related pathways are Metabolism and Peroxisomal lipid metabolism. GO annotations related to this gene include transporter activity and ATP transmembrane transporter activity. An important paralog of this gene is SLC25A32.

UniProtKB/Swiss-Prot for SLC25A17 Gene

  • Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3,5-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5-phosphate and bathophenanthroline in vitro.

Gene Wiki entry for SLC25A17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A17 Gene

Genomics for SLC25A17 Gene

Regulatory Elements for SLC25A17 Gene

Promoters for SLC25A17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A17 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A17 Gene

Chromosome:
22
Start:
40,769,630 bp from pter
End:
40,819,399 bp from pter
Size:
49,770 bases
Orientation:
Minus strand

Genomic View for SLC25A17 Gene

Genes around SLC25A17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A17 Gene

Proteins for SLC25A17 Gene

  • Protein details for SLC25A17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43808-PM34_HUMAN
    Recommended name:
    Peroxisomal membrane protein PMP34
    Protein Accession:
    O43808
    Secondary Accessions:
    • A8KA59
    • Q5TFL0
    • Q9UGW8
    • Q9UGY7

    Protein attributes for SLC25A17 Gene

    Size:
    307 amino acids
    Molecular mass:
    34567 Da
    Quaternary structure:
    • Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.

neXtProt entry for SLC25A17 Gene

Proteomics data for SLC25A17 Gene at MOPED

Post-translational modifications for SLC25A17 Gene

  • Ubiquitination at Lys 268
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC25A17

No data available for DME Specific Peptides for SLC25A17 Gene

Domains & Families for SLC25A17 Gene

Gene Families for SLC25A17 Gene

Protein Domains for SLC25A17 Gene

Suggested Antigen Peptide Sequences for SLC25A17 Gene

Graphical View of Domain Structure for InterPro Entry

O43808

UniProtKB/Swiss-Prot:

PM34_HUMAN :
  • The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Domain:
  • The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A17: view

Function for SLC25A17 Gene

Molecular function for SLC25A17 Gene

GENATLAS Biochemistry:
solute carrier protein family 25,member A17,mitochondrial carrier,peroxisomal protein,34kDa,widely expressed
UniProtKB/Swiss-Prot Function:
Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3,5-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5-phosphate and bathophenanthroline in vitro.

Gene Ontology (GO) - Molecular Function for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005347 ATP transmembrane transporter activity IGI 12445829
genes like me logo Genes that share ontologies with SLC25A17: view
genes like me logo Genes that share phenotypes with SLC25A17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A17 Gene

Localization for SLC25A17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A17 Gene

Cytoplasm. Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A17 Gene COMPARTMENTS Subcellular localization image for SLC25A17 gene
Compartment Confidence
peroxisome 5
mitochondrion 3
cytosol 2
endoplasmic reticulum 2
plasma membrane 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005779 integral component of peroxisomal membrane IDA 11121399
genes like me logo Genes that share ontologies with SLC25A17: view

Pathways & Interactions for SLC25A17 Gene

genes like me logo Genes that share pathways with SLC25A17: view

Pathways by source for SLC25A17 Gene

1 KEGG pathway for SLC25A17 Gene

Gene Ontology (GO) - Biological Process for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001561 fatty acid alpha-oxidation TAS --
GO:0006412 translation IBA --
GO:0006810 transport IEA --
GO:0035349 coenzyme A transmembrane transport IDA 22185573
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A17: view

No data available for SIGNOR curated interactions for SLC25A17 Gene

Drugs & Compounds for SLC25A17 Gene

(1) Drugs for SLC25A17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SLC25A17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A17: view

Transcripts for SLC25A17 Gene

Unigene Clusters for SLC25A17 Gene

Solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A17 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7:
SP8:

Relevant External Links for SLC25A17 Gene

GeneLoc Exon Structure for
SLC25A17
ECgene alternative splicing isoforms for
SLC25A17

Expression for SLC25A17 Gene

mRNA expression in normal human tissues for SLC25A17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A17 Gene

This gene is overexpressed in Plasma (35.4), Adrenal (10.8), and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A17 Gene



SOURCE GeneReport for Unigene cluster for SLC25A17 Gene Hs.474938

mRNA Expression by UniProt/SwissProt for SLC25A17 Gene

O43808-PM34_HUMAN
Tissue specificity: Ubiquitous. Expressed in liver.
genes like me logo Genes that share expression patterns with SLC25A17: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SLC25A17 Gene

Orthologs for SLC25A17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A17 35
  • 90.77 (n)
  • 94.46 (a)
SLC25A17 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A17 35
  • 93.7 (n)
  • 96.74 (a)
SLC25A17 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a17 35
  • 88.17 (n)
  • 95.44 (a)
Slc25a17 16
Slc25a17 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A17 35
  • 99.26 (n)
  • 99.26 (a)
SLC25A17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a17 35
  • 87.51 (n)
  • 94.79 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A17 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A17 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A17 35
  • 80.78 (n)
  • 89.58 (a)
SLC25A17 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A17 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a17 35
  • 70.89 (n)
  • 78.67 (a)
Str.1440 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398157 35
zebrafish
(Danio rerio)
Actinopterygii slc25a17 35
  • 67 (n)
  • 75.58 (a)
slc25a17 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007520 35
  • 56.69 (n)
  • 57.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32250 35
  • 54.58 (n)
  • 51.76 (a)
CG32250 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR147C 35
  • 45.93 (n)
  • 36.26 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02817g 35
  • 46.31 (n)
  • 32.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEA6 36
  • 24 (a)
ManyToMany
YIA6 36
  • 21 (a)
ManyToMany
ANT1 38
rice
(Oryza sativa)
Liliopsida Os09g0508900 35
  • 47.79 (n)
  • 38.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03556 35
  • 46.45 (n)
  • 36.1 (a)
Species with no ortholog for SLC25A17:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A17 Gene

ENSEMBL:
Gene Tree for SLC25A17 (if available)
TreeFam:
Gene Tree for SLC25A17 (if available)

Paralogs for SLC25A17 Gene

Paralogs for SLC25A17 Gene

genes like me logo Genes that share paralogs with SLC25A17: view

Variants for SLC25A17 Gene

Sequence variations from dbSNP and Humsavar for SLC25A17 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs12159334 - 40,792,566(+) TAGAA(C/T)GTTGA intron-variant, nc-transcript-variant, reference, missense
rs11806 -- 40,770,131(-) TCCAT(C/T)CTTAC nc-transcript-variant, utr-variant-3-prime
rs118026 -- 40,801,429(-) AGAAT(A/G)CTCTC intron-variant
rs138293 -- 40,785,332(+) tgagc(A/G)gagat intron-variant
rs138294 -- 40,785,582(+) tgtaa(A/G)taaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A17 Gene

Variant ID Type Subtype PubMed ID
nsv834205 CNV Gain+Loss 17160897
nsv915112 CNV Loss 21882294
dgv4978n71 CNV Loss 21882294
nsv834206 CNV Gain 17160897
nsv915115 CNV Gain 21882294

Variation tolerance for SLC25A17 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A17 Gene

HapMap Linkage Disequilibrium report
SLC25A17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A17 Gene

Disorders for SLC25A17 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLC25A17 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adrenoleukodystrophy
  • adrenomyeloneuropathy, adult
adrenomyeloneuropathy
  • adrenoleukodystrophy
peroxisome disorders
  • peroxisomal disease
cerebral degeneration
  • brain degeneration
peroxisome biogenesis disorder 1b
  • infantile refsum disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A17
genes like me logo Genes that share disorders with SLC25A17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A17 Gene

Publications for SLC25A17 Gene

  1. Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. (PMID: 9874197) Wylin T. … Van Veldhoven P.P. (Eur. J. Biochem. 1998) 2 3 4 23 67
  2. Identification of human PMP34 as a peroxisomal ATP transporter. (PMID: 12445829) Visser W.F. … Wanders R.J. (Biochem. Biophys. Res. Commun. 2002) 3 23
  3. Topogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments: study using human membrane protein PMP34. (PMID: 11121399) Honsho M. … Fujiki Y. (J. Biol. Chem. 2001) 3 23
  4. Multiple distinct targeting signals in integral peroxisomal membrane proteins. (PMID: 11402059) Jones J.M. … Gould S.J. (J. Cell Biol. 2001) 3 23
  5. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. (PMID: 10704444) Sacksteder K.A. … Gould S.J. (J. Cell Biol. 2000) 3 23

Products for SLC25A17 Gene

Sources for SLC25A17 Gene

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