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Aliases for SLC25A17 Gene

Aliases for SLC25A17 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kDa), Member 17 2 3
  • PMP34 3 4 6
  • Solute Carrier Family 25 Member 17 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kD), Member 17 2
  • Peroxisomal Membrane Protein (34kD) 2
  • 34 KDa Peroxisomal Membrane Protein 4
  • Peroxisomal Membrane Protein PMP34 3

External Ids for SLC25A17 Gene

Summaries for SLC25A17 Gene

Entrez Gene Summary for SLC25A17 Gene

  • This gene encodes a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers. It is expressed in the liver, and is likely involved in transport. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for SLC25A17 Gene

SLC25A17 (Solute Carrier Family 25 (Mitochondrial Carrier; Peroxisomal Membrane Protein, 34kDa), Member 17) is a Protein Coding gene. Diseases associated with SLC25A17 include adrenomyeloneuropathy and peroxisomal disease. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include chaperone binding and ADP transmembrane transporter activity. An important paralog of this gene is SLC25A32.

UniProtKB/Swiss-Prot for SLC25A17 Gene

  • Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3,5-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5-phosphate and bathophenanthroline in vitro.

Gene Wiki entry for SLC25A17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A17 Gene

Genomics for SLC25A17 Gene

Genomic Location for SLC25A17 Gene

Start:
40,769,630 bp from pter
End:
40,819,399 bp from pter
Size:
49,770 bases
Orientation:
Minus strand

Genomic View for SLC25A17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A17 Gene

Regulatory Elements for SLC25A17 Gene

Proteins for SLC25A17 Gene

  • Protein details for SLC25A17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43808-PM34_HUMAN
    Recommended name:
    Peroxisomal membrane protein PMP34
    Protein Accession:
    O43808
    Secondary Accessions:
    • A8KA59
    • Q5TFL0
    • Q9UGW8
    • Q9UGY7

    Protein attributes for SLC25A17 Gene

    Size:
    307 amino acids
    Molecular mass:
    34567 Da
    Quaternary structure:
    • Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.

neXtProt entry for SLC25A17 Gene

Proteomics data for SLC25A17 Gene at MOPED

Post-translational modifications for SLC25A17 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys268

No data available for DME Specific Peptides for SLC25A17 Gene

Domains for SLC25A17 Gene

Gene Families for SLC25A17 Gene

Protein Domains for SLC25A17 Gene

UniProtKB/Swiss-Prot:

PM34_HUMAN
Domain:
  • The N- and C-terminal portions are exposed to the cytoplasm. Lacks a typical peroxisomal sorting signal. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity:
    • O43808
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • O43808
Similarity:
  • Contains 3 Solcar repeats.:
    • O43808
genes like me logo Genes that share domains with SLC25A17: view

Function for SLC25A17 Gene

Molecular function for SLC25A17 Gene

GENATLAS Biochemistry: solute carrier protein family 25,member A17,mitochondrial carrier,peroxisomal protein,34kDa,widely expressed
UniProtKB/Swiss-Prot Function: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3,5-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5-phosphate and bathophenanthroline in vitro.

Gene Ontology (GO) - Molecular Function for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005347 ATP transmembrane transporter activity IGI 12445829
GO:0005515 protein binding IPI 10704444
GO:0015217 ADP transmembrane transporter activity IDA 22185573
GO:0015228 coenzyme A transmembrane transporter activity IDA 22185573
genes like me logo Genes that share ontologies with SLC25A17: view

Phenotypes for SLC25A17 Gene

GenomeRNAi human phenotypes for SLC25A17:
genes like me logo Genes that share phenotypes with SLC25A17: view

miRNA for SLC25A17 Gene

miRTarBase miRNAs that target SLC25A17

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A17 Gene

Localization for SLC25A17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A17 Gene

Cytoplasm. Peroxisome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A17 Gene COMPARTMENTS Subcellular localization image for SLC25A17 gene
Compartment Confidence
peroxisome 5
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
plasma membrane 2
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane --
GO:0005777 peroxisome IDA 9874197
GO:0005778 peroxisomal membrane TAS --
GO:0005779 integral component of peroxisomal membrane IDA 11121399
genes like me logo Genes that share ontologies with SLC25A17: view

Pathways for SLC25A17 Gene

genes like me logo Genes that share pathways with SLC25A17: view

Pathways by source for SLC25A17 Gene

1 KEGG pathway for SLC25A17 Gene

Gene Ontology (GO) - Biological Process for SLC25A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001561 fatty acid alpha-oxidation TAS --
GO:0006635 fatty acid beta-oxidation IGI 12445829
GO:0006810 transport --
GO:0015866 ADP transport IDA 22185573
GO:0015867 ATP transport IGI 12445829
genes like me logo Genes that share ontologies with SLC25A17: view

Compounds for SLC25A17 Gene

(3) Novoseek inferred chemical compound relationships for SLC25A17 Gene

Compound -log(P) Hits PubMed IDs
acyl-coa 69.5 3
atp 20 5
gold 0 1
genes like me logo Genes that share compounds with SLC25A17: view

Transcripts for SLC25A17 Gene

Unigene Clusters for SLC25A17 Gene

Solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A17 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7:
SP8:

Relevant External Links for SLC25A17 Gene

GeneLoc Exon Structure for
SLC25A17
ECgene alternative splicing isoforms for
SLC25A17

Expression for SLC25A17 Gene

mRNA expression in normal human tissues for SLC25A17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A17 Gene

SOURCE GeneReport for Unigene cluster for SLC25A17 Gene Hs.474938

mRNA Expression by UniProt/SwissProt for SLC25A17 Gene

O43808-PM34_HUMAN
Tissue specificity: Ubiquitous. Expressed in liver.
genes like me logo Genes that share expressions with SLC25A17: view

Orthologs for SLC25A17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A17 36
  • 99.26 (n)
  • 99.26 (a)
SLC25A17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A17 36
  • 90.77 (n)
  • 94.46 (a)
SLC25A17 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A17 36
  • 93.7 (n)
  • 96.74 (a)
SLC25A17 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a17 36
  • 88.17 (n)
  • 95.44 (a)
Slc25a17 16
Slc25a17 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC25A17 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A17 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a17 36
  • 87.51 (n)
  • 94.79 (a)
chicken
(Gallus gallus)
Aves SLC25A17 36
  • 80.78 (n)
  • 89.58 (a)
SLC25A17 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A17 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398157 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a17 36
  • 70.89 (n)
  • 78.67 (a)
Str.1440 36
zebrafish
(Danio rerio)
Actinopterygii slc25a17 36
  • 67 (n)
  • 75.58 (a)
slc25a17 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007520 36
  • 56.69 (n)
  • 57.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32250 36
  • 54.58 (n)
  • 51.76 (a)
CG32250 37
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR147C 36
  • 45.93 (n)
  • 36.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ANT1 39
YEA6 37
  • 24 (a)
ManyToMany
YIA6 37
  • 21 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02817g 36
  • 46.31 (n)
  • 32.44 (a)
rice
(Oryza sativa)
Liliopsida Os09g0508900 36
  • 47.79 (n)
  • 38.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03556 36
  • 46.45 (n)
  • 36.1 (a)
Species with no ortholog for SLC25A17:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A17 Gene

ENSEMBL:
Gene Tree for SLC25A17 (if available)
TreeFam:
Gene Tree for SLC25A17 (if available)

Paralogs for SLC25A17 Gene

Paralogs for SLC25A17 Gene

genes like me logo Genes that share paralogs with SLC25A17: view

Variants for SLC25A17 Gene

Sequence variations from dbSNP and Humsavar for SLC25A17 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs11806 -- 40,770,131(-) TCCAT(C/T)CTTAC utr-variant-3-prime, nc-transcript-variant
rs118026 -- 40,801,429(-) AGAAT(A/G)CTCTC intron-variant
rs138293 -- 40,785,332(+) tgagc(A/G)gagat intron-variant
rs138294 -- 40,785,582(+) tgtaa(A/G)taaag intron-variant
rs138295 -- 40,785,816(+) ttttt(G/T)gtaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A17 Gene

Variant ID Type Subtype PubMed ID
nsv834205 CNV Gain+Loss 17160897
nsv915112 CNV Loss 21882294
dgv4978n71 CNV Loss 21882294
nsv834206 CNV Gain 17160897
nsv915115 CNV Gain 21882294

Relevant External Links for SLC25A17 Gene

HapMap Linkage Disequilibrium report
SLC25A17

Disorders for SLC25A17 Gene

(3) University of Copenhagen DISEASES for SLC25A17 Gene

(7) Novoseek inferred disease relationships for SLC25A17 Gene

Disease -log(P) Hits PubMed IDs
zellweger syndrome 92.4 4
adrenoleukodystrophy 92.2 11
peroxisomal disorders 88.9 2
demyelinating diseases 38.8 1
glomerulosclerosis 14.3 2
genes like me logo Genes that share disorders with SLC25A17: view

No data available for UniProtKB/Swiss-Prot for SLC25A17 Gene

Publications for SLC25A17 Gene

  1. Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. (PMID: 9874197) Wylin T. … Van Veldhoven P.P. (Eur. J. Biochem. 1998) 2 3 4 23
  2. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. (PMID: 10704444) Sacksteder K.A. … Gould S.J. (J. Cell Biol. 2000) 3 4 23
  3. Multiple distinct targeting signals in integral peroxisomal membrane proteins. (PMID: 11402059) Jones J.M. … Gould S.J. (J. Cell Biol. 2001) 3 4 23
  4. Topogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments: study using human membrane protein PMP34. (PMID: 11121399) Honsho M. … Fujiki Y. (J. Biol. Chem. 2001) 3 4 23
  5. Identification of human PMP34 as a peroxisomal ATP transporter. (PMID: 12445829) Visser W.F. … Wanders R.J. (Biochem. Biophys. Res. Commun. 2002) 3 4 23

Products for SLC25A17 Gene

Sources for SLC25A17 Gene

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