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Aliases for SLC25A16 Gene

Aliases for SLC25A16 Gene

  • Solute Carrier Family 25 Member 16 2 3 4 5
  • Mitochondrial Solute Carrier Protein Homolog 3 4
  • Graves Disease Autoantigen 2 4
  • GdA 3 4
  • GDC 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Graves Disease Autoantigen), Member 16 3
  • Solute Carrier Family 25 (Mitochondrial Carrier), Member 16 2
  • Graves Disease Carrier Protein 3
  • D10S105E 3
  • HGT.1 3
  • HML7 3
  • ML7 3

External Ids for SLC25A16 Gene

Previous GeneCards Identifiers for SLC25A16 Gene

  • GC10U990063
  • GC10M069329
  • GC10M070134
  • GC10M069586
  • GC10M069912
  • GC10M070242
  • GC10M064242

Summaries for SLC25A16 Gene

Entrez Gene Summary for SLC25A16 Gene

  • This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. This gene has a possible role in Graves' disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC25A16 Gene

SLC25A16 (Solute Carrier Family 25 Member 16) is a Protein Coding gene. Diseases associated with SLC25A16 include Graves' Disease and Subclavian Artery Aneurysm. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. GO annotations related to this gene include antiporter activity. An important paralog of this gene is SLC25A42.

UniProtKB/Swiss-Prot for SLC25A16 Gene

  • Required for the accumulation of coenzyme A in the mitochondrial matrix.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A16 Gene

Genomics for SLC25A16 Gene

Regulatory Elements for SLC25A16 Gene

Enhancers for SLC25A16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G068470 1.1 ENCODE 11.9 +56.2 56166 2.5 HDGF PKNOX1 MLX CREB3L1 ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 DNA2 RUFY2 SLC25A16 CCAR1 MIR1254-1 TET1 DDX50 ENSG00000260400 GC10P068471 RNA5SP319
GH10G068870 1.2 Ensembl ENCODE 10.8 -344.2 -344168 2.7 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF263 REST TSHZ1 ZNF518A ZNF610 SMARCA4 STOX1 RNU6-697P DDX50 SLC25A16 PIR60428 PIR50722 GC10M068883
GH10G068550 0.9 ENCODE 12 -23.4 -23436 0.2 ELF3 HDGF RAD21 ZNF121 EGR1 ZNF143 MIXL1 EGR2 ZNF263 ZNF654 SLC25A16 CCAR1 DDX50 MIR1254-1 SNORD98 TMEM14DP TET1
GH10G068526 1.2 ENCODE 8.7 +0.2 228 2.2 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 MEF2D DDX50 DNA2 CCAR1 SUPV3L1 SIRT1 TET1 MIR1254-1 DDX21 RPL12P8 SLC25A16
GH10G068496 0.7 ENCODE 12.1 +31.3 31305 0.2 SOX13 ARID4B DMAP1 ZNF384 ZNF48 ZNF7 TEAD3 GATAD2A SOX5 HMG20A SLC25A16 RPL26P27 DNA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A16 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029157 322 2000 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 MEF2D

Genomic Location for SLC25A16 Gene

68,473,387 bp from pter
68,527,523 bp from pter
54,137 bases
Minus strand

Genomic View for SLC25A16 Gene

Genes around SLC25A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A16 Gene

Proteins for SLC25A16 Gene

  • Protein details for SLC25A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Graves disease carrier protein
    Protein Accession:
    Secondary Accessions:
    • Q8N2U1

    Protein attributes for SLC25A16 Gene

    332 amino acids
    Molecular mass:
    36224 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA36329.1; Type=Frameshift; Positions=320; Evidence={ECO:0000305};

neXtProt entry for SLC25A16 Gene

Post-translational modifications for SLC25A16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A16 Gene

Domains & Families for SLC25A16 Gene

Gene Families for SLC25A16 Gene

Suggested Antigen Peptide Sequences for SLC25A16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A16: view

Function for SLC25A16 Gene

Molecular function for SLC25A16 Gene

GENATLAS Biochemistry:
solute carrier family 25,,member A16
UniProtKB/Swiss-Prot Function:
Required for the accumulation of coenzyme A in the mitochondrial matrix.

Gene Ontology (GO) - Molecular Function for SLC25A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015291 secondary active transmembrane transporter activity TAS --
GO:0015297 antiporter activity NAS 2575220
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A16: view
genes like me logo Genes that share phenotypes with SLC25A16: view

Animal Model Products

CRISPR Products

miRNA for SLC25A16 Gene

miRTarBase miRNAs that target SLC25A16

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A16 Gene

Localization for SLC25A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A16 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A16 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 3
plasma membrane 2
peroxisome 2
cytosol 2
extracellular 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC25A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC25A16: view

Pathways & Interactions for SLC25A16 Gene

genes like me logo Genes that share pathways with SLC25A16: view

Interacting Proteins for SLC25A16 Gene

Selected Interacting proteins: P16260-GDC_HUMAN for SLC25A16 Gene via IID

Gene Ontology (GO) - Biological Process for SLC25A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport NAS 2575220
GO:0006839 mitochondrial transport IBA --
GO:0009108 coenzyme biosynthetic process TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A16: view

No data available for SIGNOR curated interactions for SLC25A16 Gene

Drugs & Compounds for SLC25A16 Gene

No Compound Related Data Available

Transcripts for SLC25A16 Gene

Unigene Clusters for SLC25A16 Gene

Solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1: - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for SLC25A16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A16 Gene

This gene is overexpressed in Liver (28.4), Placenta (12.4), Heart (11.9), and Kidney (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A16 Gene

Protein tissue co-expression partners for SLC25A16 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A16 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A16 Gene:


Evidence on tissue expression from TISSUES for SLC25A16 Gene

  • Nervous system(4.5)
  • Intestine(4.3)
  • Thyroid gland(4.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with SLC25A16: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A16 Gene

Orthologs for SLC25A16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A16 34 35
  • 99.5 (n)
(Canis familiaris)
Mammalia SLC25A16 34 35
  • 94.26 (n)
(Ornithorhynchus anatinus)
Mammalia SLC25A16 35
  • 94 (a)
(Bos Taurus)
Mammalia SLC25A16 34 35
  • 93.74 (n)
(Rattus norvegicus)
Mammalia Slc25a16 34
  • 88.82 (n)
(Mus musculus)
Mammalia Slc25a16 34 16 35
  • 87.19 (n)
(Monodelphis domestica)
Mammalia SLC25A16 35
  • 86 (a)
(Gallus gallus)
Aves SLC25A16 34 35
  • 80.66 (n)
(Anolis carolinensis)
Reptilia SLC25A16 35
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a16 34
  • 72.87 (n)
(Danio rerio)
Actinopterygii slc25a16 34 35
  • 67.98 (n)
Dr.3222 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011308 34
  • 56.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4241 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F43G9.3 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 34 35
  • 50.11 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18701g 34
  • 49.89 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL065C 34
  • 45.87 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G14560 34
  • 52.66 (n)
(Oryza sativa)
Liliopsida Os01g0571000 34
  • 52.05 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08326 34
  • 47.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17H9.08 34
  • 47.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
Species where no ortholog for SLC25A16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A16 Gene

Gene Tree for SLC25A16 (if available)
Gene Tree for SLC25A16 (if available)

Paralogs for SLC25A16 Gene

Paralogs for SLC25A16 Gene Pseudogenes for SLC25A16 Gene

genes like me logo Genes that share paralogs with SLC25A16: view

Variants for SLC25A16 Gene

Sequence variations from dbSNP and Humsavar for SLC25A16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs869312864 Likely pathogenic 68,487,193(-) TGACT(C/T)GTCGG nc-transcript-variant, reference, missense
rs1000052110 -- 68,498,416(+) CAGGC(A/G)CAGTG intron-variant
rs1000100847 -- 68,522,862(+) ACCCA(C/G)CGGTA intron-variant
rs1000114981 -- 68,483,909(+) TCCAC(A/C)CACCT intron-variant
rs1000223135 -- 68,517,694(+) CTGGG(C/T)GCAGT intron-variant, nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A16 Gene

Variant ID Type Subtype PubMed ID
dgv919n100 CNV gain 25217958
dgv920n100 CNV gain 25217958
esv2660130 CNV deletion 23128226
esv2678038 CNV deletion 23128226
esv2738029 CNV deletion 23290073
esv2738040 CNV deletion 23290073
esv2762871 CNV gain 21179565
esv3546459 CNV deletion 23714750
esv3546460 CNV deletion 23714750
esv998654 CNV deletion 20482838
nsv1037679 CNV gain 25217958
nsv1044477 CNV gain 25217958
nsv1047983 CNV gain 25217958
nsv1050943 CNV gain 25217958
nsv1068702 CNV deletion 25765185
nsv1137933 CNV deletion 24896259
nsv1137934 CNV deletion 24896259
nsv1144496 CNV deletion 24896259
nsv1145465 CNV deletion 24896259
nsv1148426 CNV deletion 26484159
nsv551434 CNV loss 21841781
nsv948047 CNV duplication 23825009

Variation tolerance for SLC25A16 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A16 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A16 Gene

Disorders for SLC25A16 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SLC25A16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
graves' disease
  • toxic diffuse goiter
subclavian artery aneurysm
  • aneurysm of subclavian artery
basilar artery occlusion
vertebral artery occlusion
  • occlusion and stenosis of vertebral artery
lemierre's syndrome
  • acute sore throat
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC25A16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A16 Gene

Publications for SLC25A16 Gene

  1. Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. (PMID: 2575220) Zarrilli R. … Kohn L.D. (Mol. Endocrinol. 1989) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SLC25A16 Gene

Sources for SLC25A16 Gene

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