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Aliases for SLC25A16 Gene

Aliases for SLC25A16 Gene

  • Solute Carrier Family 25 Member 16 2 3 4 5
  • Mitochondrial Solute Carrier Protein Homolog 3 4
  • Graves Disease Autoantigen 2 4
  • GdA 3 4
  • GDC 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Graves Disease Autoantigen), Member 16 3
  • Solute Carrier Family 25 (Mitochondrial Carrier), Member 16 2
  • Graves Disease Carrier Protein 3
  • D10S105E 3
  • HGT.1 3
  • HML7 3
  • ML7 3

External Ids for SLC25A16 Gene

Previous GeneCards Identifiers for SLC25A16 Gene

  • GC10U990063
  • GC10M069329
  • GC10M070134
  • GC10M069586
  • GC10M069912
  • GC10M070242
  • GC10M064242

Summaries for SLC25A16 Gene

Entrez Gene Summary for SLC25A16 Gene

  • This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. This gene has a possible role in Graves' disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC25A16 Gene

SLC25A16 (Solute Carrier Family 25 Member 16) is a Protein Coding gene. Diseases associated with SLC25A16 include Graves' Disease and Lemierre's Syndrome. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include antiporter activity.

UniProtKB/Swiss-Prot for SLC25A16 Gene

  • Required for the accumulation of coenzyme A in the mitochondrial matrix.

Additional gene information for SLC25A16 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A16 Gene

Genomics for SLC25A16 Gene

Regulatory Elements for SLC25A16 Gene

Enhancers for SLC25A16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H068470 1.1 ENCODE 11.9 +56.2 56166 2 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 DNA2 HERC4 SLC25A16 CCAR1 MIR1254-1 DDX50 GC10P068471 RNA5SP319
GH10H068870 1.2 Ensembl ENCODE 10.8 -344.2 -344168 2 PKNOX1 FEZF1 ZNF2 GLIS2 REST TSHZ1 ZNF518A ZNF610 GLIS1 HMBOX1 STOX1 RNU6-697P DDX50 SLC25A16 GC10M068883 PIR60428 PIR50722
GH10H068550 0.8 ENCODE 12 -23.4 -23436 0 ELF3 HDGF RAD21 ZNF121 EGR1 ZNF143 MIXL1 EGR2 ZNF654 HCFC1 SLC25A16 CCAR1 DDX50 MIR1254-1 SNORD98 TET1 TMEM14DP
GH10H068526 1.1 ENCODE 8.7 +0.2 228 2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 DDX50 CCAR1 DNA2 HNRNPH3 HERC4 SIRT1 DDX21 RPL26P27 SUPV3L1 MIR1254-1
GH10H068553 0.5 ENCODE 12 -25.8 -25836 0 HDAC2 TAL1 IKZF1 RELA SLC25A16 CCAR1 DDX50 MIR1254-1 SNORD98 TMEM14DP TET1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A16 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029157 322 2000 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for SLC25A16 Gene

Chromosome:
10
Start:
68,473,387 bp from pter
End:
68,527,523 bp from pter
Size:
54,137 bases
Orientation:
Minus strand

Genomic View for SLC25A16 Gene

Genes around SLC25A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A16 Gene

Proteins for SLC25A16 Gene

  • Protein details for SLC25A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16260-GDC_HUMAN
    Recommended name:
    Graves disease carrier protein
    Protein Accession:
    P16260
    Secondary Accessions:
    • Q8N2U1

    Protein attributes for SLC25A16 Gene

    Size:
    332 amino acids
    Molecular mass:
    36224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36329.1; Type=Frameshift; Positions=320; Evidence={ECO:0000305};

neXtProt entry for SLC25A16 Gene

Post-translational modifications for SLC25A16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A16 Gene

Domains & Families for SLC25A16 Gene

Gene Families for SLC25A16 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC25A16 Gene

Graphical View of Domain Structure for InterPro Entry

P16260

UniProtKB/Swiss-Prot:

GDC_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A16: view

Function for SLC25A16 Gene

Molecular function for SLC25A16 Gene

GENATLAS Biochemistry:
solute carrier family 25,,member A16
UniProtKB/Swiss-Prot Function:
Required for the accumulation of coenzyme A in the mitochondrial matrix.

Gene Ontology (GO) - Molecular Function for SLC25A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015291 secondary active transmembrane transporter activity TAS --
GO:0015297 antiporter activity NAS 2575220
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A16: view
genes like me logo Genes that share phenotypes with SLC25A16: view

Animal Model Products

CRISPR Products

miRNA for SLC25A16 Gene

miRTarBase miRNAs that target SLC25A16

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A16 Gene

Localization for SLC25A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A16 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A16 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 3
plasma membrane 2
peroxisome 2
cytosol 2
extracellular 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC25A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC25A16: view

Pathways & Interactions for SLC25A16 Gene

genes like me logo Genes that share pathways with SLC25A16: view

Interacting Proteins for SLC25A16 Gene

Selected Interacting proteins: P16260-GDC_HUMAN for SLC25A16 Gene via IID

Gene Ontology (GO) - Biological Process for SLC25A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport NAS 2575220
GO:0006839 mitochondrial transport IBA --
GO:0009108 coenzyme biosynthetic process TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A16: view

No data available for SIGNOR curated interactions for SLC25A16 Gene

Drugs & Compounds for SLC25A16 Gene

No Compound Related Data Available

Transcripts for SLC25A16 Gene

Unigene Clusters for SLC25A16 Gene

Solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC25A16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1: - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for SLC25A16 Gene

GeneLoc Exon Structure for
SLC25A16
ECgene alternative splicing isoforms for
SLC25A16

Expression for SLC25A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A16 Gene

This gene is overexpressed in Liver (28.4), Placenta (12.4), Heart (11.9), and Kidney (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC25A16 Gene



Protein tissue co-expression partners for SLC25A16 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC25A16 Gene:

SLC25A16

SOURCE GeneReport for Unigene cluster for SLC25A16 Gene:

Hs.180408

Evidence on tissue expression from TISSUES for SLC25A16 Gene

  • Nervous system(4.5)
  • Intestine(4.3)
  • Thyroid gland(4.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with SLC25A16: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A16 Gene

Orthologs for SLC25A16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A16 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia SLC25A16 33 34
  • 94.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A16 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC25A16 33 34
  • 93.74 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a16 33
  • 88.82 (n)
mouse
(Mus musculus)
Mammalia Slc25a16 33 16 34
  • 87.19 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A16 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC25A16 33 34
  • 80.66 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A16 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a16 33
  • 72.87 (n)
zebrafish
(Danio rerio)
Actinopterygii slc25a16 33 34
  • 67.98 (n)
Dr.3222 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011308 33
  • 56.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4241 35
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea F43G9.3 35
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 33 34
  • 50.11 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18701g 33
  • 49.89 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL065C 33
  • 45.87 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G14560 33
  • 52.66 (n)
rice
(Oryza sativa)
Liliopsida Os01g0571000 33
  • 52.05 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08326 33
  • 47.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17H9.08 33
  • 47.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for SLC25A16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A16 Gene

ENSEMBL:
Gene Tree for SLC25A16 (if available)
TreeFam:
Gene Tree for SLC25A16 (if available)

Paralogs for SLC25A16 Gene

Pseudogenes.org Pseudogenes for SLC25A16 Gene

genes like me logo Genes that share paralogs with SLC25A16: view

No data available for Paralogs for SLC25A16 Gene

Variants for SLC25A16 Gene

Sequence variations from dbSNP and Humsavar for SLC25A16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs869312864 Likely pathogenic 68,487,193(-) TGACT(C/T)GTCGG nc-transcript-variant, reference, missense
rs1000052110 -- 68,498,416(+) CAGGC(A/G)CAGTG intron-variant
rs1000100847 -- 68,522,862(+) ACCCA(C/G)CGGTA intron-variant
rs1000114981 -- 68,483,909(+) TCCAC(A/C)CACCT intron-variant
rs1000223135 -- 68,517,694(+) CTGGG(C/T)GCAGT intron-variant, nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A16 Gene

Variant ID Type Subtype PubMed ID
dgv919n100 CNV gain 25217958
dgv920n100 CNV gain 25217958
esv2660130 CNV deletion 23128226
esv2678038 CNV deletion 23128226
esv2738029 CNV deletion 23290073
esv2738040 CNV deletion 23290073
esv2762871 CNV gain 21179565
esv3546459 CNV deletion 23714750
esv3546460 CNV deletion 23714750
esv998654 CNV deletion 20482838
nsv1037679 CNV gain 25217958
nsv1044477 CNV gain 25217958
nsv1047983 CNV gain 25217958
nsv1050943 CNV gain 25217958
nsv1068702 CNV deletion 25765185
nsv1137933 CNV deletion 24896259
nsv1137934 CNV deletion 24896259
nsv1144496 CNV deletion 24896259
nsv1145465 CNV deletion 24896259
nsv1148426 CNV deletion 26484159
nsv551434 CNV loss 21841781
nsv948047 CNV duplication 23825009

Variation tolerance for SLC25A16 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A16 Gene

Human Gene Mutation Database (HGMD)
SLC25A16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A16 Gene

Disorders for SLC25A16 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SLC25A16 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
graves' disease
  • toxic diffuse goiter
lemierre's syndrome
  • acute sore throat
subclavian artery aneurysm
  • aneurysm of subclavian artery
vertebral artery occlusion
  • occlusion and stenosis of vertebral artery
basilar artery occlusion
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A16

Genetic Association Database (GAD)
SLC25A16
Human Genome Epidemiology (HuGE) Navigator
SLC25A16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A16
genes like me logo Genes that share disorders with SLC25A16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A16 Gene

Publications for SLC25A16 Gene

  1. Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. (PMID: 2575220) Zarrilli R … Kohn LD (Molecular endocrinology (Baltimore, Md.) 1989) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for SLC25A16 Gene

Sources for SLC25A16 Gene

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