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Aliases for SLC25A16 Gene

Aliases for SLC25A16 Gene

  • Solute Carrier Family 25 Member 16 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier), Member 16 2 3 5
  • Graves Disease Autoantigen 2 3 4
  • Mitochondrial Solute Carrier Protein Homolog 3 4
  • GdA 3 4
  • GDC 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Graves Disease Autoantigen), Member 16 3
  • D10S105E 3
  • HGT.1 3
  • HML7 3
  • ML7 3

External Ids for SLC25A16 Gene

Previous GeneCards Identifiers for SLC25A16 Gene

  • GC10U990063
  • GC10M069329
  • GC10M070134
  • GC10M069586
  • GC10M069912
  • GC10M070242
  • GC10M064242

Summaries for SLC25A16 Gene

Entrez Gene Summary for SLC25A16 Gene

  • This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. This gene has a possible role in Graves' disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC25A16 Gene

SLC25A16 (Solute Carrier Family 25 Member 16) is a Protein Coding gene. Diseases associated with SLC25A16 include Graves' Disease and Sphenoid Sinusitis. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. GO annotations related to this gene include antiporter activity. An important paralog of this gene is SLC25A42.

UniProtKB/Swiss-Prot for SLC25A16 Gene

  • Required for the accumulation of coenzyme A in the mitochondrial matrix.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A16 Gene

Genomics for SLC25A16 Gene

Regulatory Elements for SLC25A16 Gene

Enhancers for SLC25A16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC25A16 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A16 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A16 Gene

68,473,387 bp from pter
68,527,523 bp from pter
54,137 bases
Minus strand

Genomic View for SLC25A16 Gene

Genes around SLC25A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A16 Gene

Proteins for SLC25A16 Gene

  • Protein details for SLC25A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Graves disease carrier protein
    Protein Accession:
    Secondary Accessions:
    • Q8N2U1

    Protein attributes for SLC25A16 Gene

    332 amino acids
    Molecular mass:
    36224 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA36329.1; Type=Frameshift; Positions=320; Evidence={ECO:0000305};

neXtProt entry for SLC25A16 Gene

Proteomics data for SLC25A16 Gene at MOPED

Post-translational modifications for SLC25A16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A16 Gene

Domains & Families for SLC25A16 Gene

Gene Families for SLC25A16 Gene

Suggested Antigen Peptide Sequences for SLC25A16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A16: view

Function for SLC25A16 Gene

Molecular function for SLC25A16 Gene

GENATLAS Biochemistry:
solute carrier family 25,,member A16
UniProtKB/Swiss-Prot Function:
Required for the accumulation of coenzyme A in the mitochondrial matrix.
genes like me logo Genes that share phenotypes with SLC25A16: view

Animal Model Products

CRISPR Products

miRNA for SLC25A16 Gene

miRTarBase miRNAs that target SLC25A16

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A16 Gene

Localization for SLC25A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A16 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A16 Gene COMPARTMENTS Subcellular localization image for SLC25A16 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2
peroxisome 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A16 Gene

Pathways & Interactions for SLC25A16 Gene

genes like me logo Genes that share pathways with SLC25A16: view

Interacting Proteins for SLC25A16 Gene

Selected Interacting proteins: P16260-GDC_HUMAN for SLC25A16 Gene via I2D

Gene Ontology (GO) - Biological Process for SLC25A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport NAS 2575220
GO:0015939 pantothenate metabolic process TAS --
genes like me logo Genes that share ontologies with SLC25A16: view

No data available for SIGNOR curated interactions for SLC25A16 Gene

Drugs & Compounds for SLC25A16 Gene

No Compound Related Data Available

Transcripts for SLC25A16 Gene

Unigene Clusters for SLC25A16 Gene

Solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1: - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for SLC25A16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A16 Gene

mRNA expression in normal human tissues for SLC25A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A16 Gene

This gene is overexpressed in Liver (28.4), Placenta (12.4), Heart (11.9), and Kidney (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLC25A16 Gene

SOURCE GeneReport for Unigene cluster for SLC25A16 Gene Hs.180408

genes like me logo Genes that share expression patterns with SLC25A16: view

Protein tissue co-expression partners for SLC25A16 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC25A16 Gene

Orthologs for SLC25A16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC25A16 35
  • 93.74 (n)
  • 95.54 (a)
SLC25A16 36
  • 61 (a)
(Canis familiaris)
Mammalia SLC25A16 35
  • 94.26 (n)
  • 96.69 (a)
SLC25A16 36
  • 96 (a)
(Mus musculus)
Mammalia Slc25a16 35
  • 87.19 (n)
  • 94.14 (a)
Slc25a16 16
Slc25a16 36
  • 93 (a)
(Pan troglodytes)
Mammalia SLC25A16 35
  • 99.5 (n)
  • 99.4 (a)
SLC25A16 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc25a16 35
  • 88.82 (n)
  • 95.44 (a)
(Monodelphis domestica)
Mammalia SLC25A16 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A16 36
  • 94 (a)
(Gallus gallus)
Aves SLC25A16 35
  • 80.66 (n)
  • 85.57 (a)
SLC25A16 36
  • 82 (a)
(Anolis carolinensis)
Reptilia SLC25A16 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a16 35
  • 72.87 (n)
  • 75.08 (a)
(Danio rerio)
Actinopterygii Dr.3222 35
slc25a16 35
  • 67.98 (n)
  • 76.72 (a)
slc25a16 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4241 37
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011308 35
  • 56.85 (n)
  • 57.82 (a)
(Caenorhabditis elegans)
Secernentea F43G9.3 37
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL065C 35
  • 45.87 (n)
  • 38.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18701g 35
  • 49.89 (n)
  • 43.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU5 35
  • 50.11 (n)
  • 41.78 (a)
LEU5 36
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G14560 35
  • 52.66 (n)
  • 46.74 (a)
(Oryza sativa)
Liliopsida Os01g0571000 35
  • 52.05 (n)
  • 46.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08326 35
  • 47.88 (n)
  • 44.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17H9.08 35
  • 47.1 (n)
  • 35.84 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for SLC25A16:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A16 Gene

Gene Tree for SLC25A16 (if available)
Gene Tree for SLC25A16 (if available)

Paralogs for SLC25A16 Gene

Paralogs for SLC25A16 Gene Pseudogenes for SLC25A16 Gene

genes like me logo Genes that share paralogs with SLC25A16: view

Variants for SLC25A16 Gene

Sequence variations from dbSNP and Humsavar for SLC25A16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1832875 -- 68,508,129(+) AGCAG(A/G)CTGAA intron-variant
rs3200066 -- 68,482,960(-) TGTTA(C/T)CTCTC intron-variant, utr-variant-3-prime
rs3740591 -- 68,527,546(+) TGTCA(C/G/T)GCGCC upstream-variant-2KB
rs3740592 -- 68,527,595(+) ACAGG(C/G)CGTCA upstream-variant-2KB
rs1969758 -- 68,480,687(-) AAACC(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A16 Gene

Variant ID Type Subtype PubMed ID
nsv895692 CNV Loss 21882294
esv2660130 CNV Deletion 23128226
esv2738029 CNV Deletion 23290073
esv2738040 CNV Deletion 23290073
esv2678038 CNV Deletion 23128226
esv998654 CNV Deletion 20482838

Variation tolerance for SLC25A16 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC25A16 Gene

Disorders for SLC25A16 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC25A16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
graves' disease
  • toxic diffuse goiter
sphenoid sinusitis
  • sphenoidal sinusitis
subclavian artery aneurysm
  • aneurysm of subclavian artery
basilar artery occlusion
  • hematometra
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC25A16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A16 Gene

Publications for SLC25A16 Gene

  1. Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. (PMID: 2575220) Zarrilli R. … Kohn L.D. (Mol. Endocrinol. 1989) 2 3 4 67
  2. Regional assignment of the gene coding for a human Graves' disease autoantigen to 10q21.3-q22.1. (PMID: 8444471) Rossi E. … Zuffardi O. (Hum. Genet. 1993) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PMID: 23266187) Palmieri F. (Mol. Aspects Med. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for SLC25A16 Gene

Sources for SLC25A16 Gene