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SLC25A16 Gene

protein-coding   GIFtS: 57
GCID: GC10M070242

Solute Carrier Family 25 (Mitochondrial Carrier; Graves...

  See SLC25A16-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Graves Disease
Autoantigen), Member 161 2
     D10S105E2 5
GDA2 3 5     HGT.12
Graves Disease Autoantigen2 3     ML72
Mitochondrial Solute Carrier Protein Homolog2 3     Graves Disease Carrier Protein2
Solute Carrier Family 25 Member 162 3     hML72
GDC2 3     

External Ids:    HGNC: 109861   Entrez Gene: 80342   Ensembl: ENSG000001229127   OMIM: 1390805   UniProtKB: P162603   

Export aliases for SLC25A16 gene to outside databases

Previous GC identifers: GC10U990063 GC10M069329 GC10M070134 GC10M069586 GC10M069912 GC10M064242


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A16 Gene:
This gene encodes a protein that contains three tandemly repeated mitochondrial carrier protein domains. The
encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules
between the cytosol and the mitochondrial matrix space. This gene has a possible role in Graves' disease.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SLC25A16 Gene:
SLC25A16 (solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16) is a protein-coding gene. Diseases associated with SLC25A16 include sphenoid sinusitis, and subclavian artery aneurysm. GO annotations related to this gene include antiporter activity. An important paralog of this gene is SLC25A24.

UniProtKB/Swiss-Prot: GDC_HUMAN, P16260
Function: Required for the accumulation of coenzyme A in the mitochondrial matrix




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A16 gene promoter:
         c-Fos   CREB   c-Rel   AP-1   HOXA5   deltaCREB   Pax-6   c-Jun   RelA   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC25A16 promoter sequence
   Search Chromatin IP Primers for SLC25A16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q21.3-q22.1

SLC25A16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A16 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M070242:  view genomic region     (about GC identifiers)

Start:
70,237,756 bp from pter      End:
70,287,280 bp from pter
Size:
49,525 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GDC_HUMAN, P16260 (See protein sequence)
Recommended Name: Graves disease carrier protein  
Size: 332 amino acids; 36224 Da
Sequence caution: Sequence=AAA36329.1; Type=Frameshift; Positions=320;
Secondary accessions: Q8N2U1

Explore the universe of human proteins at neXtProt for SLC25A16: NX_P16260

Explore proteomics data for SLC25A16 at MOPED


See SLC25A16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689920.1  
ENSEMBL proteins: 
 ENSP00000476815   ENSP00000476283   ENSP00000477328   ENSP00000476587   ENSP00000476555  
 ENSP00000443914  
Reactome Protein details: P16260

SLC25A16 Human Recombinant Protein Products:

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Novus Biologicals SLC25A16 Lysate
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Cloud-Clone Corp. Proteins for SLC25A16

 
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SLC25A16 Antibody Products:

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LSBio Antibodies in human, mouse, rat for SLC25A16

SLC25A16 Assay Products:

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Cloud-Clone Corp. ELISAs for SLC25A16
Cloud-Clone Corp. CLIAs for SLC25A16
Search eBioscience for ELISAs for SLC25A16 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Graves disease carrier
Mitochondrial nucleotide transporters

4 InterPro protein domains:
 IPR002067 Mit_carrier
 IPR023395 Mt_carrier_dom
 IPR018108 Mitochondrial_sb/sol_carrier
 IPR002167 Graves_DC

Graphical View of Domain Structure for InterPro Entry P16260

ProtoNet protein and cluster: P16260

2 Blocks protein domains:
IPB002067 Mitochondrial carrier protein signature
IPB002167 Graves disease carrier protein signature


UniProtKB/Swiss-Prot: GDC_HUMAN, P16260
Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
Similarity: Contains 3 Solcar repeats


Find genes that share domains with SLC25A16           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: GDC_HUMAN, P16260
Function: Required for the accumulation of coenzyme A in the mitochondrial matrix

     Genatlas biochemistry entry for SLC25A16:
solute carrier family 25,,member A16

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015297antiporter activity NAS2575220
     
Find genes that share ontologies with SLC25A16           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for SLC25A16:
 Decreased Salmonella enterica  

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A16
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC25A16

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC25A16
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC25A16

miRNA
Products:
    
miRTarBase miRNAs that target SLC25A16:
hsa-mir-124-3p (MIRT022969)

Block miRNA regulation of human, mouse, rat SLC25A16 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC25A16 (see all 12):
hsa-miR-27a hsa-miR-1271 hsa-miR-16-1* hsa-miR-7 hsa-miR-1253 hsa-miR-1297 hsa-miR-182 hsa-miR-542-3p
SwitchGear 3'UTR luciferase reporter plasmidSLC25A16 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for SLC25A16
Predesigned siRNA for gene silencing in human, mouse, rat SLC25A16

Gene Editing
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OriGene clones in human, mouse for SLC25A16 (see all 6)
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GenScript: all cDNA clones in your preferred vector: SLC25A16 (NM_152707)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A16
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A16

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A16


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
GDC_HUMAN, P16260: Mitochondrion inner membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytoskeleton3
cytosol2
extracellular2
peroxisome2
chloroplast1
endoplasmic reticulum1
nucleus1
plasma membrane1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane TAS--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with SLC25A16           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SLC25A16 About    
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Defective BTD causes biotidinase deficiency
Defective BTD causes biotidinase deficiency1.00
Metabolism of vitamins and cofactors1.00
Defective AMN causes hereditary megaloblastic anemia 11.00
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
Defective MMAA causes methylmalonic aciduria type cblA1.00
Defective MUT causes methylmalonic aciduria mut type1.00
Defective CD320 causes methylmalonic aciduria1.00
Defects in cobalamin (B12) metabolism1.00
2Metabolism
Metabolism0.38
3Disease
Disease


Find genes that share SuperPaths with SLC25A16           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for SLC25A16
    Coenzyme A biosynthesis


    Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A16: 
          Mitochondria in human mouse rat

Interactions:

    GeneGlobe Interaction Network for SLC25A16

Selected Interacting proteins for SLC25A16 (P162603) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
InteractantInteraction Details
GeneCardExternal ID(s)
CEPT1Q9Y6K03I2D: score=1 
COQ7Q998073I2D: score=1 
DLSTP369573I2D: score=1 
DPH5Q9H2P93I2D: score=1 
FHP079543I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006766vitamin metabolic process TAS--
GO:0006767water-soluble vitamin metabolic process TAS--
GO:0006810transport NAS2575220
GO:0009108coenzyme biosynthetic process TAS--
GO:0015939pantothenate metabolic process TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC25A16 (GDC)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SLC25A16 gene: 
NM_152707.3  

Unigene Cluster for SLC25A16:

Solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
Hs.180408  [show with all ESTs]
Unigene Representative Sequence: AK123772
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000439904 ENST00000609923 ENST00000265870(uc001joi.3 uc010qiy.2 uc001joj.3)
ENST00000493963 ENST00000608053 ENST00000474927 ENST00000491102 ENST00000539557

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SLC25A16 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SLC25A16 (see all 12):
hsa-miR-27a hsa-miR-1271 hsa-miR-16-1* hsa-miR-7 hsa-miR-1253 hsa-miR-1297 hsa-miR-182 hsa-miR-542-3p
SwitchGear 3'UTR luciferase reporter plasmidSLC25A16 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SLC25A16
Predesigned siRNA for gene silencing in human, mouse, rat SLC25A16
Clone
Products:
     
OriGene clones in human, mouse for SLC25A16 (see all 6)
OriGene ORF clones in mouse, rat for SLC25A16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SLC25A16 (NM_152707)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A16
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A16
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A16
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A16
  QuantiTect SYBR Green Assays in human, mouse, rat SLC25A16
  QuantiFast Probe-based Assays in human, mouse, rat SLC25A16

Additional mRNA sequence: 

AK123772.1 AK290255.1 AK295287.1 AK298510.1 BC023330.1 BC030266.1 XR_159036.1 XR_159199.1 
XR_171859.1 

8 DOTS entries:

DT.442598  DT.92063802  DT.425169  DT.91683238  DT.91810434  DT.121292992  DT.91685595  DT.91685596 

Selected AceView cDNA sequences (see all 135):

BF430917 AI305170 BE894822 AW189403 CR609697 BM966945 BX356395 NM_152707 
BG770901 N58858 CA407379 AI927020 BX095000 AK123772 BI915572 AA411554 
AI271909 BX358664 CR607953 AA232631 AI718237 AI474167 BG253612 BE929733 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A16    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1:                    -     -     -           -                                 
SP2:                    -     -     -                             -               
SP3:                                            -                                 
SP4:                    -     -                                                   
SP5:                    -                                                         


ECgene alternative splicing isoforms for SLC25A16

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC25A16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SLC25A16 Expression
About this image


SLC25A16 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Heart (Cardiovascular System)
         Atrioventricular Node
SLC25A16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC25A16 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.180408
    Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A16: 
          Mitochondria in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A16
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A16
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QuantiFast Probe-based Assays in human, mouse, rat SLC25A16
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A16

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A16 gene from Selected species (see all 24)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc25a161 , 5 solute carrier family 25 (mitochondrial carrier, Graves more1, 5 87.19(n)1
94.14(a)1
  10 (32.50 cM)5
731321  NM_175194.21  NP_780403.11 
 629206335 
chicken
(Gallus gallus)
Aves SLC25A161 solute carrier family 25 (mitochondrial carrier; Graves more 80.66(n)
85.57(a)
  423689  XM_421570.4  XP_421570.2 
lizard
(Anolis carolinensis)
Reptilia SLC25A166
solute carrier family 25 (mitochondrial carrier; G...
80(a)
1 ↔ 1
GL343215.1(1603079-1639892)
African clawed frog
(Xenopus laevis)
Amphibia CA788199.12   -- 76.78(n)    CA788199.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.32222 Danio rerio mRNA similar to RIKEN cDNA 3110021G18 gene more 74.71(n)    BC045977.1 
mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP0113081 AgaP_AGAP011308 56.85(n)
57.82(a)
  1270626  XM_309341.4  XP_309341.4 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LEU51 LEU5 50.11(n)
41.78(a)
  856391   NP_011865.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G145601 AT1G14560 52.66(n)
46.74(a)
  838018  NM_101323.2  NP_172908.1 
rice
(Oryza sativa)
Liliopsida Os01g05710001 Os01g0571000 52.05(n)
46.54(a)
  4326348  NM_001049910.1  NP_001043375.1 


ENSEMBL Gene Tree for SLC25A16 (if available)
TreeFam Gene Tree for SLC25A16 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC25A16 gene
SLC25A242  SLC25A232  SLC25A422  SLC25A252  SLC25A412  SLC25A432  
10 SIMAP similar genes for SLC25A16 using alignment to 6 protein entries:     GDC_HUMAN (see all proteins):
LOC203427    SLC25A24    SLC25A23    SLC25A42    SLC25A43    DKFZp667O1614
SLC25A19    SLC25A31    SLC25A4    SLC25A17

Find genes that share paralogs with SLC25A16           About GenesLikeMe


1 Pseudogenes.org Pseudogene for SLC25A16
PGOHUM00000245960


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC25A16 (see all 1101)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs32000661,2
C,F,H--70242717(-) TGTTAT/CCTCTC 1 -- ut31 trp316Minor allele frequency- C:0.10MN NS EA NA CSA WA 1956
rs794589781,2
C,F--70242804(+) CCCTGT/CTTATT 1 -- ut311Minor allele frequency- C:0.07WA 118
rs109982191,2
C,F,A,H--70242905(+) AACCCC/TGTTTT 1 -- ut3115Minor allele frequency- T:0.10NS EA NA CSA WA 1893
rs43502641,2
C,F,A,H--70242946(+) AAAGCG/AGTTTA 1 -- ut31 ese310Minor allele frequency- A:0.09NS EA NA 802
rs1816118491,2
--70243016(+) AAAGTA/GTGGTA 1 -- ut310--------
rs1429722561,2
--70243115(+) AATGTA/TCCCCC 1 -- ut310--------
rs1507407521,2
C--70243179(+) AACCAA/C/TAATTT 2 -- ut310--------
rs1838602041,2
C--70243213(+) TGCTTC/TATAAG 2 I M mis10--------
rs1391077491,2
C--70243299(+) TTTTCA/GAATTC 2 R * stg10--------
rs1494567781,2
C--70243568(+) GCACGC/TGCCAC 1 -- int10--------

HapMap Linkage Disequilibrium report for SLC25A16 (70237756 - 70287280 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for SLC25A16:    About this table    
Variant IDTypeSubtypePubMed ID
esv2678038CNV Deletion23128226
esv998654CNV Deletion20482838
esv2738040CNV Deletion23290073
esv2738029CNV Deletion23290073
esv2660130CNV Deletion23128226
nsv895692CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 139080    OMIM disorders: --

4 diseases for SLC25A16:    
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sphenoid sinusitis    subclavian artery aneurysm    hemometra    graves' disease

5 diseases from the University of Copenhagen DISEASES database for SLC25A16:
Intracranial aneurysm     Congenital mitral regurgitation     Subclavian artery aneurysm     Hemometra
Sphenoid sinusitis

Find genes that share disorders with SLC25A16           About GenesLikeMe

Genetic Association Database (GAD): SLC25A16
Human Genome Epidemiology (HuGE) Navigator: SLC25A16 (3 documents)

Export disorders for SLC25A16 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC25A16 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with SLC25A16)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. (PubMed id 2575220)1, 2, 3 Zarrilli R.... Kohn L.D. (Mol. Endocrinol. 1989)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix. (PubMed id 11158296)1, 2 Prohl C....Lill R. (Mol. Cell. Biol. 2001)
  7. Regional assignment of the gene coding for a human Graves' disease autoantigen to 10q21.3-q22.1. (PubMed id 8444471)1, 3 Rossi E....Zuffardi O. (Hum. Genet. 1993)
  8. Sequence and pattern of expression of a bovine homologue of a human mitochondrial transport protein associated with Grave's disease. (PubMed id 1457817)1, 2 Fiermonte G.... Palmieri F. (DNA Seq. 1992)
  9. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (Mol. Aspects Med. 2013)
  10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8034 HGNC: 10986 AceView: SLC25A16 Ensembl:ENSG00000122912 euGenes: HUgn8034
ECgene: SLC25A16 H-InvDB: SLC25A16

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC25A16 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC25A16 gene:
Search GeneIP for patents involving SLC25A16

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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