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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A15 Gene

protein-coding   GIFtS: 58
GCID: GC13P041363

Solute Carrier Family 25 (Mitochondrial Carrier; Ornithine...


(Previous symbols: ORNT1, HHH)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Ornithine Transporter)
Member 151 2
     Solute Carrier Family 25 Member 152 3
ORNT11 2 3 5     D13S3272
HHH1 2 5     ORC12
Ornithine Transporter 11 2     Mitochondrial Ornithine Transporter 12

External Ids:    HGNC: 109851   Entrez Gene: 101662   Ensembl: ENSG000001027437   OMIM: 6038615   UniProtKB: Q9Y6193   

Export aliases for SLC25A15 gene to outside databases

Previous GC identifers: GC13P039350 GC13P035350 GC13P040300 GC13P039161 GC13P040261 GC13P022163


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A15 Gene:
This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the
inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component
of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine.
Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a
pseudogene of this locus on the Y chromosome.(provided by RefSeq, May 2009)

GeneCards Summary for SLC25A15 Gene: 
SLC25A15 (solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15) is a protein-coding gene. Diseases associated with SLC25A15 include gyrate atrophy, and urea cycle disorder, and among its related super-pathways are urea cycle and Metabolic pathways. GO annotations related to this gene include L-ornithine transmembrane transporter activity. An important paralog of this gene is SLC25A2.

UniProtKB/Swiss-Prot: ORNT1_HUMAN, Q9Y619
Function: Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A15 gene promoter:
         Max1   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   STAT2   Cart-1   STAT3   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLC25A15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.11   HGNC cytogenetic band: 13q14

SLC25A15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A15 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P041363:  view genomic region     (about GC identifiers)

Start:
41,363,547 bp from pter      End:
41,386,596 bp from pter
Size:
23,050 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ORNT1_HUMAN, Q9Y619 (See protein sequence)
Recommended Name: Mitochondrial ornithine transporter 1  
Size: 301 amino acids; 32736 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: Q5VZD8 Q9HC45

Explore the universe of human proteins at neXtProt for SLC25A15: NX_Q9Y619

Explore proteomics data for SLC25A15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y619

  • SLC25A15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC25A15 Protein Expression
    REFSEQ proteins: NP_055067.1  
    ENSEMBL proteins: 
     ENSP00000342267   ENSP00000415826   ENSP00000431429  
    Reactome Protein details: Q9Y619
    Human Recombinant Protein Products for SLC25A15: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral to membrane IEA--

    SLC25A15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial ornithine transporter 1  
    Mitochondrial ornithine transporters

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9Y619

    ProtoNet protein and cluster: Q9Y619

    UniProtKB/Swiss-Prot: ORNT1_HUMAN, Q9Y619
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORNT1_HUMAN, Q9Y619
    Function: Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix

         Genatlas biochemistry entry for SLC25A15:
    solute carrier family 25,member A15,ornithine transporter,inner mitochondrial membrane,expressed in liver and
    pancreas with variated changes in dietary protein linked to ornithine translocase

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000064L-ornithine transmembrane transporter activity TAS10369256
         
    SLC25A15 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidSLC25A15 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC25A15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1glutamate degradation X
    Urea cycle0.56
    2Metabolism
    Metabolism0.40
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for SLC25A15
        Metabolism
    Metabolism of amino acids and derivatives
    Urea cycle



    SLC25A15 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC25A15

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC25A15 (ENSP000003422674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASS1ENSP000002530044STRING: ENSP00000253004
    OTCENSP000000390074STRING: ENSP00000039007
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000050urea cycle TAS--
    GO:0000066mitochondrial ornithine transport TAS10369256
    GO:0006520cellular amino acid metabolic process TAS10369256
    GO:0006810transport ----
    GO:0034641cellular nitrogen compound metabolic process TAS--

    SLC25A15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC25A15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC25A15 (ORNT1)

    1 HMDB Compound for SLC25A15    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--

    1 DrugBank Compound for SLC25A15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--14759633 16940241

    2 Novoseek inferred chemical compound relationships for SLC25A15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 79.8 18 12948741 (3), 16940241 (2), 10369256 (2), 11712419 (1) (see all 10)
    urea 47.1 3 16940241 (1), 10369256 (1), 19287344 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC25A15 / ORNT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC25A15 gene: 
    NM_014252.3  

    Unigene Cluster for SLC25A15:

    Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
    Hs.646645  [show with all ESTs]
    Unigene Representative Sequence: NM_014252
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478827 ENST00000338625 ENST00000417731 ENST00000470509
    miRNA
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    Additional mRNA sequence: 

    AF177333.1 AK296862.1 AK313602.1 BC002702.2 

    5 DOTS entries:

    DT.95268372  DT.92008085  DT.95237088  DT.95320722  DT.75151949 

    24/127 AceView cDNA sequences (see all 127):

    BE384292 BU726339 AI672058 BQ642838 AW296850 BQ014130 BM833224 BQ060013 
    AA344884 AA683539 BC002702 AV685923 CR597405 AI339297 W88672 BQ062125 
    AA397728 AI885329 AI143096 AI380717 BG391603 AI474445 C20961 AI262596 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A15    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:                                -                     


    ECgene alternative splicing isoforms for SLC25A15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATGCTTA
    SLC25A15 Expression
    About this image


    See SLC25A15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC25A15

    SOURCE GeneReport for Unigene cluster: Hs.646645
        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC25A15: 
              Mitochondrial Energy Metabolism in human mouse rat
              Mitochondria in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC25A15 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a151 , 5 solute carrier family 25 (mitochondrial carrier ornithine more1, 5 86.49(n)1
    95.02(a)1
      8 (11.26 cM)5
    184081  NM_181325.41  NP_851842.11 
     223755545 
    chicken
    (Gallus gallus)
    Aves SLC25A151 solute carrier family 25 (mitochondrial carrier; ornithine more 75.53(n)
    80.4(a)
      418886  NM_001008442.1  NP_001008442.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    81(a)
    59(a)
    1 ↔ many
    possible ortholog
    1(132584192-132595501)
    GL343599.1(106922-121935)
    zebrafish
    (Danio rerio)
    Actinopterygii slc25a15a1 solute carrier family 25 (mitochondrial carrier; ornithine more 68.45(n)
    67.56(a)
      791156  NM_001080638.1  NP_001074107.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16281 , 3 carrier3
    CG16281
    47(a)3
    53.92(n)1
    48.42(a)1
      319901  NM_132411.21  NP_572639.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T10F2.21 , 3 Mitochondrial carrier protein3
    Protein T10F2.21
    49(a)3
    53.14(n)1
    51.66(a)1
      III(5235744-5237075)3
    1883871  NM_065693.21  NP_498094.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GGC1(YDL198C)4 Mitochondrial GTP/GDP transporter, essential for mitochondrial more   --   4(104551-103649) 851329  NP_010083.1 


    ENSEMBL Gene Tree for SLC25A15 (if available)
    TreeFam Gene Tree for SLC25A15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A15 gene
    SLC25A22  
    6 SIMAP similar genes for SLC25A15 using alignment to 3 protein entries:     ORNT1_HUMAN (see all proteins):
    SLC25A2    SLC25A45    SLC25A20    SLC25A29    SLC25A48    SLC25A47

    SLC25A15 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for SLC25A15
    PGOHUM00000248511 PGOHUM00000248543 PGOHUM00000239123 PGOHUM00000246199 PGOHUM00000233886


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/571 SNPs in SLC25A15 are shown (see all 571)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0589544
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0589542 T I mis40--------
    VAR_0589514
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0589512 G C mis40--------
    VAR_0127644
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0127642 R Q mis40--------
    VAR_0127604
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0127602 E K mis40--------
    VAR_0589494
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0589492 A L mis40--------
    VAR_0127574
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0127572 G E mis40--------
    VAR_0127584
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0127582 G R mis40--------
    VAR_0589564
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0589562 L F mis40--------
    VAR_0127624
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0127622 G D mis40--------
    VAR_0589484
    Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome)4--see VAR_0589482 M R mis40--------

    HapMap Linkage Disequilibrium report for SLC25A15 (41363547 - 41386596 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC25A15: --

    Human Gene Mutation Database (HGMD): SLC25A15

    Locus Specific Mutation Databases (LSDB): SLC25A15
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603861   
    OMIM disorders: 238970  
    UniProtKB/Swiss-Prot: ORNT1_HUMAN, Q9Y619
  • Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome) [MIM:238970]: Autosomal
    recessive disorder resulting in various neurologic symptoms, including mental retardation, spastic paraparesis
    with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma caused by
    hyperammonemia. It causes a functional impairment of the urea cycle. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 9 diseases for SLC25A15:    About MalaCards
    gyrate atrophy    urea cycle disorder    cerebellar ataxia    intellectual disability
    spastic paraparesis    spasticity    ataxia    mental retardation
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for SLC25A15:
    Ornithine translocase deficiency

    SLC25A15 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SLC25A15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hhh syndrome 99.5 21 12948741 (2), 16940241 (2), 10805333 (2), 10369256 (2) (see all 14)
    gyrate atrophy 92.1 9 14759633 (2), 11668643 (2), 10805333 (1)
    hyperammonemia 89.4 9 14759633 (2), 11668643 (2), 10805333 (1)

    Genetic Association Database (GAD): SLC25A15
    Human Genome Epidemiology (HuGE) Navigator: SLC25A15 (2 documents)

    Export disorders for SLC25A15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A15 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with SLC25A15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. (PubMed id 10369256)1, 2, 3, 9 Camacho J.A.... Valle D. (1999)
    2. Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family. (PubMed id 14759633)1, 7, 9 Korman S.H....Tsujino S. (2004)
    3. Seven novel mutations in the ORNT1 gene (SLC25A15) in patients with hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome. (PubMed id 11668643)1, 2, 9 Salvi S.... Santorelli F.M. (2001)
    4. Three novel mutations (G27E, insAAC, R179X) in the ORNT1 gene of Japanese patients with hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome. (PubMed id 10805333)1, 2, 9 Tsujino S....Yamada T. (2000)
    5. Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: a clinical, molecular, and functional study. (PubMed id 19242930)1, 2, 9 Tessa A.... Santorelli F.M. (2009)
    6. A novel mutation, P126R, in a Japanese patient with HHH syndrome. (PubMed id 11814739)1, 2, 9 Miyamoto T.... Tsujino S. (2002)
    7. Clinical and molecular findings in hyperornithinemia-hyperammonemia- homocitrullinuria syndrome. (PubMed id 11552031)1, 2, 9 Salvi S....Dionisi-Vici C. (2001)
    8. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    9. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10166 HGNC: 10985 AceView: SLC25A15 Ensembl:ENSG00000102743 euGenes: HUgn10166
    ECgene: SLC25A15 H-InvDB: SLC25A15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A15 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC25A15

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC25A15 gene:
    Search GeneIP for patents involving SLC25A15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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