Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC25A14 Gene

protein-coding   GIFtS: 58
GCID: GC0XP129473

Solute Carrier Family 25 (Mitochondrial Carrier, Brain),...

  See SLC25A14-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 25 (Mitochondrial Carrier, Brain), Member 141 2     Brain Mitochondrial Carrier Protein 12
BMCP12 3 5     BMCP-13
Mitochondrial Uncoupling Protein 52 3     Solute Carrier Family 25 Member 143
UCP52 3     UCP 53

External Ids:    HGNC: 109841   Entrez Gene: 90162   Ensembl: ENSG000001020787   OMIM: 3002425   UniProtKB: O952583   

Export aliases for SLC25A14 gene to outside databases

Previous GC identifers: GC0XP124119 GC0XP126319 GC0XP127418 GC0XP128179 GC0XP129199 GC0XP129301 GC0XP118868


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC25A14 Gene:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins
(MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat,
also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the
inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner
mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is
widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in
multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. (provided by RefSeq,
Aug 2013)

GeneCards Summary for SLC25A14 Gene:
SLC25A14 (solute carrier family 25 (mitochondrial carrier, brain), member 14) is a protein-coding gene. Diseases associated with SLC25A14 include congenital nystagmus. An important paralog of this gene is UCP3.

UniProtKB/Swiss-Prot: UCP5_HUMAN, O95258
Function: Participates in the mitochondrial proton leak measured in brain mitochondria

Gene Wiki entry for SLC25A14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A14 gene promoter:
         Bach1   GR   AML1a   AP-4   CUTL1   Evi-1   FOXL1   FOXC1   Sox9   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A14 promoter sequence
   Search Chromatin IP Primers for SLC25A14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq24

SLC25A14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A14 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP129473:  view genomic region     (about GC identifiers)

Start:
129,473,874 bp from pter      End:
129,507,335 bp from pter
Size:
33,462 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UCP5_HUMAN, O95258 (See protein sequence)
Recommended Name: Brain mitochondrial carrier protein 1  
Size: 325 amino acids; 36202 Da
Secondary accessions: D3DTG2 Q0VDH7 Q9HC60 Q9HC61
Alternative splicing: 3 isoforms:  O95258-1   O95258-2   O95258-3   

Explore the universe of human proteins at neXtProt for SLC25A14: NX_O95258

Explore proteomics data for SLC25A14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC25A14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269124.1  NP_001269125.1  NP_001269126.1  NP_001269127.1  

    ENSEMBL proteins: 
     ENSP00000402578   ENSP00000218197   ENSP00000354455   ENSP00000342797   ENSP00000444642  
     ENSP00000445225  

    SLC25A14 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC25A14
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC25A14
    GenScript Custom Purified and Recombinant Proteins Services for SLC25A14
    Novus Biologicals SLC25A14 Protein
    Novus Biologicals SLC25A14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC25A14 

    SLC25A14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC25A14
    Novus Biologicals SLC25A14 Antibodies
    Search for Antibodies for SLC25A14 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SLC25A14
    LSBio Antibodies in human, mouse, rat for SLC25A14

    SLC25A14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC25A14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC25A14
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC25A14 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Uncoupling protein 5
    Mitochondrial uncoupling proteins

    3 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR002030 Mit_uncoupling
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry O95258

    ProtoNet protein and cluster: O95258

    1 Blocks protein domain: IPB002030 Mitochondrial brown fat uncoupling protein signature

    UniProtKB/Swiss-Prot: UCP5_HUMAN, O95258
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    Find genes that share domains with SLC25A14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCP5_HUMAN, O95258
    Function: Participates in the mitochondrial proton leak measured in brain mitochondria

         Genatlas biochemistry entry for SLC25A14:
    solute carrier family 25,mitochondrial,predominantly expressed in the brain,particularily in
    cortex,hippocampus,thalamus,amygdala,hyppothalamus

    Phenotypes:
         1 GenomeRNAi human phenotype for SLC25A14:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC25A14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC25A14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC25A14

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC25A14:
    hsa-mir-331-3p (MIRT043502), hsa-mir-182-5p (MIRT047204)

    Block miRNA regulation of human, mouse, rat SLC25A14 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SLC25A14:
    hsa-miR-376b hsa-miR-637 hsa-miR-532-5p hsa-miR-3176 hsa-miR-589 hsa-miR-376a hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC25A14
    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC25A14

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC25A14 (see all 12)
    OriGene ORF clones in mouse, rat for SLC25A14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC25A14 (NM_003951)
    Sino Biological Human cDNA Clone for SLC25A14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A14

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC25A14
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC25A14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UCP5_HUMAN, O95258: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane4
    extracellular1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS9852133
    GO:0005740mitochondrial envelope ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005887integral component of plasma membrane TAS9852133
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC25A14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC25A14 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.75


    1 BioSystems Pathway for SLC25A14
        Electron Transport Chain



        Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A14: 
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC25A14

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9852133
    GO:0006839mitochondrial transport IEA--
    GO:0009060aerobic respiration TAS9852133

    Find genes that share ontologies with SLC25A14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC25A14 (UCP5)

    1 Novoseek inferred chemical compound relationship for SLC25A14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydrogen 7.01 3 10736318 (1), 15119950 (1)



    Find genes that share compounds with SLC25A14           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC25A14 gene (6 alternative transcripts): 
    NM_001282195.1  NM_001282196.1  NM_001282197.1  NM_001282198.1  NM_003951.2  NM_022810.1  

    Unigene Cluster for SLC25A14:

    Solute carrier family 25 (mitochondrial carrier, brain), member 14
    Hs.194686  [show with all ESTs]
    Unigene Representative Sequence: AF078544
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495156 ENST00000464342 ENST00000464184 ENST00000424447 ENST00000218197(uc004evp.1 uc004evq.1 uc004evr.1)
    ENST00000467496 ENST00000361980 ENST00000339231 ENST00000478474 ENST00000467346
    ENST00000471795 ENST00000465988 ENST00000545805 ENST00000543953(uc011muu.2 uc010nrg.3 uc011mut.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC25A14 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SLC25A14:
    hsa-miR-376b hsa-miR-637 hsa-miR-532-5p hsa-miR-3176 hsa-miR-589 hsa-miR-376a hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC25A14
    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A14
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC25A14 (see all 12)
    OriGene ORF clones in mouse, rat for SLC25A14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC25A14 (NM_003951)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A14
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC25A14
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A14
      QuantiTect SYBR Green Assays in human, mouse, rat SLC25A14
      QuantiFast Probe-based Assays in human, mouse, rat SLC25A14

    Additional mRNA sequence: 

    AF078544.1 AF155809.1 AF155811.1 AK296155.1 AK297499.1 AK304649.1 AK309433.1 AY358099.1 
    BC119666.2 BC119667.1 

    11 DOTS entries:

    DT.114058  DT.91740284  DT.95273783  DT.121320137  DT.101968332  DT.95283410  DT.121320135  DT.95273786 
    DT.91740282  DT.91740289  DT.95296309 

    Selected AceView cDNA sequences (see all 111):

    AA401224 AL552019 AA015832 CR611993 CR606300 CR609375 BI764542 NM_022810 
    AI697106 AF155809 AI131262 BI488448 AF155811 AA035652 BM451371 BQ022609 
    AL711106 AF155810 NM_003951 BE677828 BF347687 BE294015 BU677812 R19440 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A14    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
    SP1:                                                  -     -                       -                           
    SP2:              -                                   -     -                       -                           
    SP3:                                                  -                                                         
    SP4:                          -                       -     -                                                   
    SP5:              -     -     -                                                                                 


    ECgene alternative splicing isoforms for SLC25A14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC25A14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACTTTTC
    SLC25A14 Expression
    About this image

    SLC25A14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC25A14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194686

    UniProtKB/Swiss-Prot: UCP5_HUMAN, O95258
    Tissue specificity: Mainly expressed in brain. Some expression in testis and pituitary

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC25A14: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC25A14
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A14
    QuantiTect SYBR Green Assays in human, mouse, rat SLC25A14
    QuantiFast Probe-based Assays in human, mouse, rat SLC25A14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SLC25A14 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a141 , 5 solute carrier family 25 (mitochondrial carrier, brain), more1, 5 89.44(n)1
    97.52(a)1
      X (25.69 cM)5
    205231  NM_001166450.11  NP_001159922.11 
     486234135 
    chicken
    (Gallus gallus)
    Aves SLC25A141 solute carrier family 25 (mitochondrial carrier, brain), more 77.18(n)
    91.04(a)
      422141  NM_001012883.1  NP_001012901.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC25A146
    solute carrier family 25 (mitochondrial carrier, b...
    85(a)
    1 ↔ 1
    GL343451.1(308653-321101)
    zebrafish
    (Danio rerio)
    Actinopterygii slc25a141 solute carrier family 25 (mitochondrial carrier, brain), more 71.21(n)
    79.37(a)
      393133  NM_200164.1  NP_956458.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bmcp3 carrier 55(a)   68D3   --


    ENSEMBL Gene Tree for SLC25A14 (if available)
    TreeFam Gene Tree for SLC25A14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC25A14 gene
    UCP32  UCP12  UCP22  SLC25A112  ENSG000002626602  SLC25A102  SLC25A302  SLC25A272  
    10 SIMAP similar genes for SLC25A14 using alignment to 4 protein entries:     UCP5_HUMAN (see all proteins):
    SLC25A30    UCP3    UCP2    UCP1    SLC25A27    SLC25A11
    SLC25A10    SLC25A35    SLC25A23    SLC25A25

    Find genes that share paralogs with SLC25A14           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLC25A14
    PGOHUM00000245987


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC25A14 (see all 426)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38346941,2
    C--129428402(-) cgatc-/TCggctc 2 -- us2k10--------
    rs1462048611,2
    --129428465(+) ACAAAC/TAAAAC 2 -- us2k10--------
    rs1813426551,2
    C--129428506(+) GAGAAA/CTATCC 2 -- us2k10--------
    rs1843011221,2
    --129428630(+) TCTCGC/TGTGAT 2 -- us2k10--------
    rs1886003511,2
    --129428687(+) AAATCA/GGACGT 2 -- us2k10--------
    rs347159351,2
    C,F,H--129428767(+) GAGTCG/AGAAGC 2 -- us2k18Minor allele frequency- A:0.39EA NS NA 700
    rs173149101,2
    C,F--129428810(+) TTATGA/GGGTTT 2 -- us2k16Minor allele frequency- G:0.33NA CSA 147
    rs1810761201,2
    --129428854(+) GCCTCA/CTCTGT 2 -- us2k10--------
    rs1860596511,2
    C--129428940(+) TCGAGC/TAAGGG 2 -- us2k10--------
    rs37615711,2
    C--129429354(-) CGGGCA/GCATCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC25A14 (129473874 - 129507335 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC25A14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510559CNV Loss20534489
    nsv528290CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): SLC25A14

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC25A14
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300242    OMIM disorders: --

    1 disease for SLC25A14:    
    About MalaCards
    congenital nystagmus

    1 disease from the University of Copenhagen DISEASES database for SLC25A14:
    Congenital nystagmus

    Find genes that share disorders with SLC25A14           About GenesLikeMe

    Genetic Association Database (GAD): SLC25A14
    Human Genome Epidemiology (HuGE) Navigator: SLC25A14 (2 documents)

    Export disorders for SLC25A14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC25A14 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with SLC25A14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. (PubMed id 9852133)1, 2, 3, 9 Sanchis D....Ricquier D. (J. Biol. Chem. 1998)
    2. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. (PubMed id 10928996)1, 2, 9 Yu X.X.... Pan G. (FASEB J. 2000)
    3. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PubMed id 17066476)1, 4 Yasuno K....Tamiya G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Amplified expression of uncoupling proteins in human brain ischemic lesions. (PubMed id 18018477)1, 9 Nakase T....Nagata K. (Neuropathology 2007)
    8. Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude. (PubMed id 23266757)1 Xu Y....Liu J.Z. (Neurochem. Res. 2013)
    9. The mitochondrial transporter family SLC25: identification, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (Mol. Aspects Med. 2013)
    10. Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5. (PubMed id 22524567)1 Hoang T....Jelokhani-Niaraki M. (Biochemistry 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9016 HGNC: 10984 AceView: SLC25A14 Ensembl:ENSG00000102078 euGenes: HUgn9016
    ECgene: SLC25A14 H-InvDB: SLC25A14

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC25A14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC25A14 gene:
    Search GeneIP for patents involving SLC25A14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC25A14  
     OriGene qPCR primer pairs and template standards for SLC25A14   OriGene Protein Over-expression Lysate for SLC25A14  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC25A14  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC25A14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC25A14   OriGene Custom Protein Services for SLC25A14  

     
     
     Block miRNA regulation of human, mouse, rat SLC25A14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC25A14
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A14 Predesigned siRNA for gene silencing in human, mouse, rat SLC25A14
     QuantiFast Probe-based Assays in human, mouse, rat SLC25A14 QuantiTect SYBR Green Assays in human, mouse, rat SLC25A14
     PCR Arrays including human, mouse, rat SLC25A14 Search Chromatin IP Primers for SLC25A14
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A14  Search GeneGlobe Interaction Network for SLC25A14
     Regulatory tfbs in SLC25A14 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC25A14 GenScript cDNA clones with any tag delivered in your preferred vector for SLC25A14
     GenScript Custom Assay Services for SLC25A14 GenScript Custom overexpressing Cell Line Services for SLC25A14
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC25A14 (UCP5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SLC25A14
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC25A14 antibodies
     SLC25A14 proteins
     SLC25A14 lysates
     Search for Antibodies for SLC25A14 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC25A14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC25A14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A14
     SwitchGear 3'UTR luciferase reporter plasmids for SLC25A14
     SwitchGear Promoter luciferase reporter plasmids for SLC25A14
     ThermoFisher Antibodies for SLC25A14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A14
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A14
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC25A14
     LSBio Antibodies in human, mouse, rat for SLC25A14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC25A14
      Search eBioscience for proteins for SLC25A14
      Search eBioscience for elisas for SLC25A14
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC25A14 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4