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Aliases for SLC25A11 Gene

Aliases for SLC25A11 Gene

  • Solute Carrier Family 25 Member 11 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate Carrier), Member 11 2 3
  • SLC20A4 3 4
  • OGCP 3 4
  • Solute Carrier Family 20 (Oxoglutarate Carrier), Member 4 3
  • Mitochondrial 2-Oxoglutarate/Malate Carrier Protein 3
  • OGC 3

External Ids for SLC25A11 Gene

Previous HGNC Symbols for SLC25A11 Gene

  • SLC20A4

Previous GeneCards Identifiers for SLC25A11 Gene

  • GC17M005260
  • GC17M004785
  • GC17M005041
  • GC17M004782
  • GC17M004840

Summaries for SLC25A11 Gene

Entrez Gene Summary for SLC25A11 Gene

  • The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]

GeneCards Summary for SLC25A11 Gene

SLC25A11 (Solute Carrier Family 25 Member 11) is a Protein Coding gene. Diseases associated with SLC25A11 include Breast Leiomyosarcoma and Oculogyric Crisis. Among its related pathways are Glucose metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include poly(A) RNA binding and oxoglutarate:malate antiporter activity. An important paralog of this gene is ENSG00000262660.

UniProtKB/Swiss-Prot for SLC25A11 Gene

  • Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

Gene Wiki entry for SLC25A11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A11 Gene

Genomics for SLC25A11 Gene

Regulatory Elements for SLC25A11 Gene

Enhancers for SLC25A11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G004852 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +86.6 86616 3.3 CTCF NFIB ZIC2 RAD21 ZFHX2 POLR2A ZNF547 EED PRDM10 EGR2 CHRNE MINK1 PLD2 CXCL16 ZMYND15 SLC25A11 RNF167 SPAG7 ENO3 PFN1
GH17G004965 1.4 ENCODE dbSUPER 12.3 -28.4 -28366 5.4 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 SPAG7 ZNF232 INCA1 CHRNE LOC100130950 LOC101927979 KIF1C DHX33 CAMTA2 RNF167
GH17G004856 1.5 Ensembl ENCODE dbSUPER 10.8 +81.5 81476 5.3 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ETS1 TCF12 GATA2 CHRNE C17orf107 ZFP3 MINK1 PLD2 ARRB2 PELP1 RPS12P29 LOC101559451 ENO3
GH17G004996 1.1 ENCODE 11.8 -58.6 -58596 4.2 HDGF MLX ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF766 ZNF143 CHRNE CAMTA2 ENSG00000234203 SPAG7 SLC25A11 RNF167 PFN1 ENO3 INCA1 KIF1C
GH17G004837 1.2 ENCODE dbSUPER 10.5 +101.1 101143 3.9 HDAC1 HDGF PKNOX1 CBX3 TBL1XR1 CREB3L1 ARNT ZSCAN4 ZBTB40 ZNF335 CHRNE ENO3 SPAG7 PLD2 VMO1 GLTPD2 ZMYND15 CXCL16 ENSG00000234203 PFN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A11 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A11 Gene

Chromosome:
17
Start:
4,937,130 bp from pter
End:
4,940,251 bp from pter
Size:
3,122 bases
Orientation:
Minus strand

Genomic View for SLC25A11 Gene

Genes around SLC25A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A11 Gene

Proteins for SLC25A11 Gene

  • Protein details for SLC25A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02978-M2OM_HUMAN
    Recommended name:
    Mitochondrial 2-oxoglutarate/malate carrier protein
    Protein Accession:
    Q02978
    Secondary Accessions:
    • F5GY65
    • O75537
    • Q969P7

    Protein attributes for SLC25A11 Gene

    Size:
    314 amino acids
    Molecular mass:
    34062 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A11 Gene

Post-translational modifications for SLC25A11 Gene

  • Ubiquitination at isoforms=57, Lys62, isoforms=73, and Lys162
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A11 Gene

No data available for DME Specific Peptides for SLC25A11 Gene

Domains & Families for SLC25A11 Gene

Gene Families for SLC25A11 Gene

Protein Domains for SLC25A11 Gene

Graphical View of Domain Structure for InterPro Entry

Q02978

UniProtKB/Swiss-Prot:

M2OM_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A11: view

Function for SLC25A11 Gene

Molecular function for SLC25A11 Gene

GENATLAS Biochemistry:
solute carrier family 25 mitochondrial member 11,inner mitochondrial membrane,catalyzing the transport of 2-oxoglutarate for malate and other dicarboxylic acids,involved in malate-aspartate shuttle,oxoglutarate-isocitrate shuttle,gluco neogenesis and nitrogen metabolism
UniProtKB/Swiss-Prot Function:
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

Gene Ontology (GO) - Molecular Function for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0015367 oxoglutarate:malate antiporter activity TAS --
genes like me logo Genes that share ontologies with SLC25A11: view
genes like me logo Genes that share phenotypes with SLC25A11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A11

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A11 Gene

Localization for SLC25A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A11 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A11 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA,IEA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1457818
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A11: view

Pathways & Interactions for SLC25A11 Gene

genes like me logo Genes that share pathways with SLC25A11: view

Pathways by source for SLC25A11 Gene

Gene Ontology (GO) - Biological Process for SLC25A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
GO:0006810 transport TAS,IEA 1457818
GO:0006839 mitochondrial transport IBA --
GO:0015742 alpha-ketoglutarate transport IEA --
genes like me logo Genes that share ontologies with SLC25A11: view

No data available for SIGNOR curated interactions for SLC25A11 Gene

Drugs & Compounds for SLC25A11 Gene

(2) Additional Compounds for SLC25A11 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with SLC25A11: view

Transcripts for SLC25A11 Gene

Unigene Clusters for SLC25A11 Gene

Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for SLC25A11 Gene

GeneLoc Exon Structure for
SLC25A11
ECgene alternative splicing isoforms for
SLC25A11

Expression for SLC25A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC25A11 Gene

This gene is overexpressed in Nasal epithelium (19.5) and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A11 Gene



Protein tissue co-expression partners for SLC25A11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A11 Gene:

SLC25A11

SOURCE GeneReport for Unigene cluster for SLC25A11 Gene:

Hs.184877

Evidence on tissue expression from TISSUES for SLC25A11 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Muscle(4.4)
  • Lung(2.3)
  • Intestine(2.2)
  • Kidney(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with SLC25A11: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A11 Gene

Orthologs for SLC25A11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC25A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A11 34 35
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia SLC25A11 34 35
  • 92.25 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC25A11 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC25A11 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A11 34 35
  • 91.61 (n)
mouse
(Mus musculus)
Mammalia Slc25a11 34 16 35
  • 90.32 (n)
rat
(Rattus norvegicus)
Mammalia Slc25a11 34
  • 89.33 (n)
lizard
(Anolis carolinensis)
Reptilia SLC25A11 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a11 34
  • 78.18 (n)
Str.8212 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13480 34
zebrafish
(Danio rerio)
Actinopterygii slc25a11 34 35
  • 73.8 (n)
wufa07h09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11128 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012097 34
  • 63.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1907 36 34 35
  • 62.98 (n)
CG18418 36 35
  • 54 (a)
CG7514 36 35
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea B0432.4 36
  • 72 (a)
misc-1 34 35
  • 63.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 35
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19760 34
  • 51.02 (n)
rice
(Oryza sativa)
Liliopsida Os11g0432400 34
  • 52.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7200 35
  • 75 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU10732 34
  • 50.66 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.987 34
Species where no ortholog for SLC25A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A11 Gene

ENSEMBL:
Gene Tree for SLC25A11 (if available)
TreeFam:
Gene Tree for SLC25A11 (if available)

Paralogs for SLC25A11 Gene

(11) SIMAP similar genes for SLC25A11 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC25A11: view

Variants for SLC25A11 Gene

Sequence variations from dbSNP and Humsavar for SLC25A11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000580299 -- 4,937,142(+) TTTTC(C/T)GGCCC utr-variant-3-prime
rs1001333628 -- 4,939,520(+) GACTC(C/T)AGGTA intron-variant, upstream-variant-2KB
rs1001935294 -- 4,940,684(+) ACCAG(A/G)AAAGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002984190 -- 4,941,730(+) TGGCC(A/G)ACATG intron-variant, upstream-variant-2KB
rs1003134444 -- 4,937,351(+) GAGGG(A/G)GAGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A11 Gene

Variant ID Type Subtype PubMed ID
dgv3088n100 CNV gain 25217958
esv3572365 CNV gain 25503493
nsv574273 CNV gain 21841781
nsv574275 CNV gain 21841781
nsv833347 CNV loss 17160897
nsv833349 CNV loss 17160897
nsv833350 CNV loss 17160897

Variation tolerance for SLC25A11 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A11 Gene

Disorders for SLC25A11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC25A11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast leiomyosarcoma
  • leiomyosarcoma of the breast
oculogyric crisis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC25A11

Genetic Association Database (GAD)
SLC25A11
Human Genome Epidemiology (HuGE) Navigator
SLC25A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A11
genes like me logo Genes that share disorders with SLC25A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC25A11 Gene

Publications for SLC25A11 Gene

  1. Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3. (PMID: 10072597) Piccininni S. … Palmieri F. (Cytogenet. Cell Genet. 1998) 2 3 22 64
  2. Sequences of the human and bovine genes for the mitochondrial 2- oxoglutarate carrier. (PMID: 1457818) Iacobazzi V. … Walker J.E. (DNA Seq. 1992) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. (PMID: 16920706) Kabe Y. … Handa H. (J. Biol. Chem. 2006) 3 22 64

Products for SLC25A11 Gene

Sources for SLC25A11 Gene

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