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SLC25A11 Gene

protein-coding   GIFtS: 61
GCID: GC17M004840

Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate...


(Previous symbol: SLC20A4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate Carrier),
Member 111 2
     OGC2 5
SLC20A41 2 3 5     Mitochondrial 2-Oxoglutarate/Malate Carrier Protein2
Solute Carrier Family 25 Member 112 3     Solute Carrier Family 20 (Oxoglutarate Carrier), Member 42
OGCP2 3     

External Ids:    HGNC: 109811   Entrez Gene: 84022   Ensembl: ENSG000001085287   OMIM: 6041655   UniProtKB: Q029783   

Export aliases for SLC25A11 gene to outside databases

Previous GC identifers: GC17M005260 GC17M004785 GC17M005041 GC17M004782


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC25A11 Gene:
The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an
electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 (PubMed
1457818)).(supplied by OMIM, Jan 2011)

GeneCards Summary for SLC25A11 Gene:
SLC25A11 (solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11) is a protein-coding gene. Diseases associated with SLC25A11 include granulomatous gastritis, and complex partial epilepsy. GO annotations related to this gene include oxoglutarate:malate antiporter activity. An important paralog of this gene is ENSG00000262660.

UniProtKB/Swiss-Prot: M2OM_HUMAN, Q02978
Function: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral
exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes,
including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and
in nitrogen metabolism

Gene Wiki entry for SLC25A11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A11 gene promoter:
         E2F-3a   E2F   E2F-1   E2F-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A11 promoter sequence
   Search Chromatin IP Primers for SLC25A11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

SLC25A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M004840:  view genomic region     (about GC identifiers)

Start:
4,840,425 bp from pter      End:
4,843,546 bp from pter
Size:
3,122 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M2OM_HUMAN, Q02978 (See protein sequence)
Recommended Name: Mitochondrial 2-oxoglutarate/malate carrier protein  
Size: 314 amino acids; 34062 Da
Secondary accessions: F5GY65 O75537 Q969P7
Alternative splicing: 2 isoforms:  Q02978-1   Q02978-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for SLC25A11: NX_Q02978

Explore proteomics data for SLC25A11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15, Lys57, Lys62, Lys73, Lys162
  • Modification sites at PhosphoSitePlus

  • See SLC25A11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001158889.1  NP_001158890.1  NP_003553.2  

    ENSEMBL proteins: 
     ENSP00000225665   ENSP00000440804   ENSP00000458993  
    Reactome Protein details: Q02978

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial oxoglutarate carrier
    Mitochondrial di- and tri-carboxylic acid transporters

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q02978

    ProtoNet protein and cluster: Q02978

    UniProtKB/Swiss-Prot: M2OM_HUMAN, Q02978
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M2OM_HUMAN, Q02978
    Function: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral
    exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes,
    including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and
    in nitrogen metabolism

         Genatlas biochemistry entry for SLC25A11:
    solute carrier family 25 mitochondrial member 11,inner mitochondrial membrane,catalyzing the transport of
    2-oxoglutarate for malate and other dicarboxylic acids,involved in malate-aspartate
    shuttle,oxoglutarate-isocitrate shuttle,gluco neogenesis and nitrogen metabolism

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015367oxoglutarate:malate antiporter activity TAS--
    GO:0044822poly(A) RNA binding IDA--
         
    SLC25A11 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidSLC25A11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M2OM_HUMAN, Q02978: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane4
    cytosol2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005887integral component of plasma membrane TAS1457818
    GO:0016021integral component of membrane ----

    SLC25A11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC25A11 About    
    See pathways by source

    SuperPathContained pathways About
    1Glucose metabolism
    Glucose metabolism0.44
    Gluconeogenesis0.44
    2MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    3Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SLC25A11
        Gluconeogenesis



    SLC25A11 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC25A11
    Interactions:

        Search GeneGlobe Interaction Network for SLC25A11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC25A11 (Q029782, 3 ENSP000002256654) via UniProtKB, MINT, STRING, and/or I2D (see all 279)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1BP203332, 3MINT-49458 I2D: score=2 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    COPAP536212, 3, ENSP000003570484MINT-64040 I2D: score=5 STRING: ENSP00000357048
    CDKN1AP389363, ENSP000002447414I2D: score=3 STRING: ENSP00000244741
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006810transport TAS1457818
    GO:0015742alpha-ketoglutarate transport TAS1457818

    SLC25A11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC25A11 (M2OM)

    1 HMDB Compound for SLC25A11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--

    1 Novoseek inferred chemical compound relationship for SLC25A11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-ketoglutarate 82.7 15 16920706 (3), 16600197 (1), 19192628 (1), 11709077 (1) (see all 6)



    SLC25A11 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC25A11 gene (3 alternative transcripts): 
    NM_001165417.1  NM_001165418.1  NM_003562.4  

    Unigene Cluster for SLC25A11:

    Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
    Hs.184877  [show with all ESTs]
    Unigene Representative Sequence: BC016473
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225665(uc002fzo.2 uc021tod.1 uc021toe.1) ENST00000574710(uc002fzp.2)
    ENST00000544061 ENST00000576951 ENST00000570543
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    Additional mRNA sequence: 

    AF070548.1 AK290376.1 AK313010.1 BC006508.2 BC006519.2 BC016294.2 BC016473.1 BC017170.2 
    CR456834.1 

    20 DOTS entries:

    DT.75173986  DT.100887250  DT.100887252  DT.100887261  DT.100887258  DT.95348267  DT.100830162  DT.100887241 
    DT.100887245  DT.100887254  DT.100887253  DT.92446329  DT.100887255  DT.95167526  DT.100037898  DT.100887244 
    DT.100887251  DT.120891165  DT.95167525  DT.95167532 

    Selected AceView cDNA sequences (see all 474):

    BE906655 BQ225289 CB124740 BG982618 CF126377 AA344994 BU634021 CB147486 
    CR615026 BM749948 BG697141 BE797365 BI824113 BI822717 CR609603 BC017170 
    BQ670695 CR625556 BM921557 BF346954 CA866076 BM456740 BM310119 CB137300 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A11    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                                          
    SP2:                                -     -                                                   
    SP3:                          -                                                               
    SP4:                                                  -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for SLC25A11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC25A11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGATGATTG
    SLC25A11 Expression
    About this image


    SLC25A11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SLC25A11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC25A11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.184877
        Custom PCR Arrays for SLC25A11
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A11 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a111 , 5 solute carrier family 25 (mitochondrial carrier oxoglutarate more1, 5 90.32(n)1
    97.03(a)1
      11 (43.21 cM)5
    678631  NM_024211.31  NP_077173.11 
     706441965 
    lizard
    (Anolis carolinensis)
    Reptilia SLC25A116
    solute carrier family 25 (mitochondrial carrier; o...
    86(a)
    1 ↔ 1
    GL344523.1(22338-32286)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134802 Xenopus laevis transcribed sequence with moderate similarity more 80.08(n)    CD301759.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa07h092 wufa07h09 79.03(n)   334898  CK025948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19071 , 3 carrier3
    CG19071
    59(a)
    (best of 3)3
    62.98(n)1
    59.4(a)1
      99B53
    434831  NM_143446.21  NP_651703.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0432.43
    misc-11
    mitochrondrial 2-oxoglutarate/malate
    carrier protein3
    misc-11
    72(a)3
    63.05(n)1
    73.08(a)1
      II(286632-288605)3
    1734141  NM_061293.61  NP_493694.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIC16
    Mitochondrial dicarboxylate carrier, integral memb...
    37(a)
    1 → many
    XII(826977-827873) YLR348C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G197601 AT5G19760 51.02(n)
    46.57(a)
      832096  NM_121981.4  NP_197477.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g04324001 Os11g0432400 52.65(n)
    49.12(a)
      4350398  NM_001074325.1  NP_001067793.1 


    ENSEMBL Gene Tree for SLC25A11 (if available)
    TreeFam Gene Tree for SLC25A11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC25A11 gene
    ENSG000002626602  UCP32  UCP12  SLC25A102  UCP22  SLC25A272  SLC25A142  SLC25A302  
    11 SIMAP similar genes for SLC25A11 using alignment to 3 protein entries:     M2OM_HUMAN (see all proteins):
    SLC25A10    SLC25A22    UCP1    SLC25A35    SLC25A14    SLC25A34
    SLC25A30    SLC25A27    UCP2    UCP3    SLC25A47

    SLC25A11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC25A11 (see all 57)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs4006881,2
    C,F,A,H--4839930(+) TACACG/AGAGGC 3 -- int122Minor allele frequency- A:0.28NS EA NA WA 3012
    rs1890617441,2
    --4840042(+) AAGCAC/TTCCTC 3 -- int10--------
    rs611957031,2
    --4840111(+) GGCCTA/GGGAAC 3 -- int10--------
    rs22431071,2
    C,F,A,H--4840377(+) GCATCG/AGTGGC 3 -- int125Minor allele frequency- A:0.14NS EA NA 4918
    rs1926959371,2
    --4840387(+) CATTCC/TTGGGC 3 -- int10--------
    rs1382538421,2
    --4840393(+) TGGGCA/GAGTGG 3 -- int10--------
    rs1845059241,2
    --4840397(+) CGAGTG/TGCTGG 3 -- int10--------
    rs1438524461,2
    --4840411(+) AAACAC/TACCGG 3 -- int10--------
    rs1505822071,2
    --4840446(+) CCTGTC/TAGCTG 3 -- ut310--------
    rs1386338431,2
    --4840504(+) CTTTTC/TCTTTA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC25A11 (4840425 - 4843546 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC25A11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907621CNV Loss21882294
    nsv907620CNV Loss21882294
    nsv833347CNV Loss17160897
    nsv833350CNV Loss17160897
    nsv833349CNV Loss17160897
    nsv907619CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC25A11
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604165    OMIM disorders: --

    15 diseases for SLC25A11:    
    About MalaCards
    granulomatous gastritis    complex partial epilepsy    lung giant cell carcinoma    asperger syndrome
    gastritis    giant cell tumor    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    tonsillitis    choroiditis    malaria    neuroblastoma
    cerebritis    thyroiditis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SLC25A11:
    Asperger syndrome

    SLC25A11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC25A11
    Human Genome Epidemiology (HuGE) Navigator: SLC25A11 (4 documents)

    Export disorders for SLC25A11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC25A11 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with SLC25A11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequences of the human and bovine genes for the mitochondrial 2- oxoglutarate carrier. (PubMed id 1457818)1, 2, 3 Iacobazzi V.... Walker J.E. (DNA Seq. 1992)
    2. Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3. (PubMed id 10072597)1, 3, 9 Piccininni S....Palmieri F. (Cytogenet. Cell Genet. 1998)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier. (PubMed id 8597574)1, 9 Bisaccia F....Palmieri F. (Biochim. Biophys. Acta 1996)
    7. Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. (PubMed id 16920706)1, 9 Kabe Y....Handa H. (J. Biol. Chem. 2006)
    8. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The mitochondrial oxoglutarate carrier: from identification to mechanism. (PubMed id 23054077)1 MonnAc M....Fiermonte G. (J. Bioenerg. Biomembr. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8402 HGNC: 10981 AceView: SLC25A11 Ensembl:ENSG00000108528 euGenes: HUgn8402
    ECgene: SLC25A11 H-InvDB: SLC25A11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC25A11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC25A11 gene:
    Search GeneIP for patents involving SLC25A11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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