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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A11 Gene

protein-coding   GIFtS: 61
GCID: GC17M004840

Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate...


(Previous symbol: SLC20A4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Oxoglutarate Carrier),
Member 111 2
     OGC2 5
SLC20A41 2 3 5     Mitochondrial 2-Oxoglutarate/Malate Carrier Protein2
Solute Carrier Family 25 Member 112 3     Solute Carrier Family 20 (Oxoglutarate Carrier), Member 42
OGCP2 3     

External Ids:    HGNC: 109811   Entrez Gene: 84022   Ensembl: ENSG000001085287   OMIM: 6041655   UniProtKB: Q029783   

Export aliases for SLC25A11 gene to outside databases

Previous GC identifers: GC17M005260 GC17M004785 GC17M005041 GC17M004782


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A11 Gene:
The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an
electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 (PubMed
1457818)).(supplied by OMIM, Jan 2011)

GeneCards Summary for SLC25A11 Gene: 
SLC25A11 (solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11) is a protein-coding gene. Diseases associated with SLC25A11 include granulomatous gastritis, and complex partial epilepsy, and among its related super-pathways are Glucose metabolism and MPS IIIC - Sanfilippo syndrome C. GO annotations related to this gene include oxoglutarate:malate antiporter activity. An important paralog of this gene is ENSG00000262660.

UniProtKB/Swiss-Prot: M2OM_HUMAN, Q02978
Function: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral
exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes,
including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and
in nitrogen metabolism

Gene Wiki entry for SLC25A11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A11 gene promoter:
         E2F-3a   E2F   E2F-1   E2F-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

SLC25A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M004840:  view genomic region     (about GC identifiers)

Start:
4,840,425 bp from pter      End:
4,843,546 bp from pter
Size:
3,122 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M2OM_HUMAN, Q02978 (See protein sequence)
Recommended Name: Mitochondrial 2-oxoglutarate/malate carrier protein  
Size: 314 amino acids; 34062 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: F5GY65 O75537 Q969P7
Alternative splicing: 2 isoforms:  Q02978-1   Q02978-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for SLC25A11: NX_Q02978

Explore proteomics data for SLC25A11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02978

  • SLC25A11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC25A11 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001158889.1  NP_001158890.1  NP_003553.2  

    ENSEMBL proteins: 
     ENSP00000225665   ENSP00000440804   ENSP00000458993  
    Reactome Protein details: Q02978
    Human Recombinant Protein Products for SLC25A11: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005887integral to plasma membrane TAS1457818
    GO:0016021integral to membrane ----

    SLC25A11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial oxoglutarate carrier 
    Mitochondrial di- and tri-carboxylic acid transporters

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q02978

    ProtoNet protein and cluster: Q02978

    UniProtKB/Swiss-Prot: M2OM_HUMAN, Q02978
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M2OM_HUMAN, Q02978
    Function: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral
    exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes,
    including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and
    in nitrogen metabolism

         Genatlas biochemistry entry for SLC25A11:
    solute carrier family 25 mitochondrial member 11,inner mitochondrial membrane,catalyzing the transport of
    2-oxoglutarate for malate and other dicarboxylic acids,involved in malate-aspartate
    shuttle,oxoglutarate-isocitrate shuttle,gluco neogenesis and nitrogen metabolism

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015367oxoglutarate:malate antiporter activity TAS--
         
    SLC25A11 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC25A11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucose metabolism
    Glucose metabolism0.50
    Gluconeogenesis0.50
    2MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    3Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SLC25A11
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism
    Glucose metabolism



    SLC25A11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/270 Interacting proteins for SLC25A11 (Q029782, 3 ENSP000002256654) via UniProtKB, MINT, STRING, and/or I2D (see all 270)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1BP203332, 3MINT-49458 I2D: score=2 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    COPAP536212, 3, ENSP000003570484MINT-64040 I2D: score=5 STRING: ENSP00000357048
    CDKN1AP389363, ENSP000002447414I2D: score=3 STRING: ENSP00000244741
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006810transport TAS1457818
    GO:0015742alpha-ketoglutarate transport TAS1457818

    SLC25A11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC25A11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC25A11 (M2OM)

    1 HMDB Compound for SLC25A11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--

    1 Novoseek inferred chemical compound relationship for SLC25A11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-ketoglutarate 82.7 15 16920706 (3), 16600197 (1), 19192628 (1), 11709077 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about SLC25A11 / M2OM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC25A11 gene (3 alternative transcripts): 
    NM_001165417.1  NM_001165418.1  NM_003562.4  

    Unigene Cluster for SLC25A11:

    Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
    Hs.184877  [show with all ESTs]
    Unigene Representative Sequence: BC016473
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225665(uc002fzo.2 uc021tod.1 uc021toe.1) ENST00000574710(uc002fzp.2)
    ENST00000544061 ENST00000576951 ENST00000570543
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    Additional mRNA sequence: 

    AF070548.1 AK290376.1 AK313010.1 BC006508.2 BC006519.2 BC016294.2 BC016473.1 BC017170.2 
    CR456834.1 

    20 DOTS entries:

    DT.75173986  DT.100887250  DT.100887252  DT.100887261  DT.100887258  DT.95348267  DT.100830162  DT.100887241 
    DT.100887245  DT.100887254  DT.100887253  DT.92446329  DT.100887255  DT.95167526  DT.100037898  DT.100887244 
    DT.100887251  DT.120891165  DT.95167525  DT.95167532 

    24/474 AceView cDNA sequences (see all 474):

    CA945187 BQ673203 BQ052294 BG982618 CR613107 BC016473 CR603391 CB153914 
    CR590793 BI918461 F01361 CR616117 BE906655 BM669422 AA311042 CB105683 
    BF339844 AA732656 BI824113 BE797365 BQ670695 BG764317 CB141930 BM310119 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A11    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                                          
    SP2:                                -     -                                                   
    SP3:                          -                                                               
    SP4:                                                  -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for SLC25A11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A11 expression in normal human tissues (normalized intensities)      SLC25A11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGATGATTG
    SLC25A11 Expression
    About this image


    SLC25A11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart muscle ; myocytes   
             atrial myocardium   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See SLC25A11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC25A11

    SOURCE GeneReport for Unigene cluster: Hs.184877
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A11 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a111 , 5 solute carrier family 25 (mitochondrial carrier oxoglutarate more1, 5 90.23(n)1
    96.5(a)1
      11 (43.21 cM)5
    678631  NM_024211.31  NP_077173.11 
     706441965 
    lizard
    (Anolis carolinensis)
    Reptilia SLC25A116
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL344523.1(22338-32286)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134802 Xenopus laevis transcribed sequence with moderate similarity more 80.08(n)    CD301759.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa07h092 wufa07h09 79.03(n)   334898  CK025948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19071 , 3 carrier3
    CG19071
    59(a)
    (best of 3)3
    63.09(n)1
    59.4(a)1
      99B53
    434831  NM_143446.21  NP_651703.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0432.43
    misc-11
    mitochrondrial 2-oxoglutarate/malate
    carrier protein3
    Protein MISC-11
    72(a)3
    63.05(n)1
    73.08(a)1
      II(286632-288605)3
    1734141  NM_061293.51  NP_493694.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIC16
    Mitochondrial dicarboxylate carrier, integral memb...
    35(a)
    1 → many
    XII(826977-827873)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G197601 Mitochondrial substrate carrier family protein 51.02(n)
    46.57(a)
      832096  NM_121981.4  NP_197477.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g04324001 hypothetical protein 53.06(n)
    49.32(a)
      4350398  NM_001074325.1  NP_001067793.1 


    ENSEMBL Gene Tree for SLC25A11 (if available)
    TreeFam Gene Tree for SLC25A11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A11 gene
    ENSG000002626602  UCP32  UCP12  UCP22  SLC25A102  SLC25A272  SLC25A142  SLC25A302  
    11 SIMAP similar genes for SLC25A11 using alignment to 3 protein entries:     M2OM_HUMAN (see all proteins):
    SLC25A10    SLC25A22    UCP1    SLC25A35    SLC25A14    SLC25A34
    SLC25A30    UCP2    UCP3    SLC25A27    SLC25A47

    SLC25A11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/57 SNPs in SLC25A11 are shown (see all 57)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs4006881,2
    C,F,A,H--4839930(+) TACACG/AGAGGC 3 -- int122Minor allele frequency- A:0.28NS EA NA WA 3012
    rs1890617441,2
    --4840042(+) AAGCAC/TTCCTC 3 -- int10--------
    rs611957031,2
    --4840111(+) GGCCTA/GGGAAC 3 -- int10--------
    rs22431071,2
    C,F,A,H--4840377(+) GCATCG/AGTGGC 3 -- int125Minor allele frequency- A:0.14NS EA NA 4918
    rs1926959371,2
    --4840387(+) CATTCC/TTGGGC 3 -- int10--------
    rs1382538421,2
    --4840393(+) TGGGCA/GAGTGG 3 -- int10--------
    rs1845059241,2
    --4840397(+) CGAGTG/TGCTGG 3 -- int10--------
    rs1438524461,2
    --4840411(+) AAACAC/TACCGG 3 -- int10--------
    rs1505822071,2
    --4840446(+) CCTGTC/TAGCTG 3 -- ut310--------
    rs1386338431,2
    --4840504(+) CTTTTC/TCTTTA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC25A11 (4840425 - 4843546 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC25A11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv907621CNV Loss21882294
    nsv907620CNV Loss21882294
    nsv833347CNV Loss17160897
    nsv833350CNV Loss17160897
    nsv833349CNV Loss17160897
    nsv907619CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604165    OMIM disorders: --

    8 diseases for SLC25A11:    About MalaCards
    granulomatous gastritis    complex partial epilepsy    lung giant cell carcinoma    gastritis
    giant cell tumor    intrahepatic cholangiocarcinoma    cholangiocarcinoma    alcoholism

    1 disease from the University of Copenhagen DISEASES database for SLC25A11:
    Asperger syndrome

    SLC25A11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC25A11
    Human Genome Epidemiology (HuGE) Navigator: SLC25A11 (4 documents)

    Export disorders for SLC25A11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A11 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with SLC25A11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier. (PubMed id 1457818)1, 2, 3 Iacobazzi V....Walker J.E. (1992)
    2. Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3. (PubMed id 10072597)1, 3, 9 Piccininni S....Palmieri F. (1998)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier. (PubMed id 8597574)1, 9 Bisaccia F....Palmieri F. (1996)
    7. Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. (PubMed id 16920706)1, 9 Kabe Y....Handa H. (2006)
    8. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (2013)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. The mitochondrial oxoglutarate carrier: from identific ation to mechanism. (PubMed id 23054077)1 Monne M....Fiermonte G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8402 HGNC: 10981 AceView: SLC25A11 Ensembl:ENSG00000108528 euGenes: HUgn8402
    ECgene: SLC25A11 H-InvDB: SLC25A11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC25A11 gene:
    Search GeneIP for patents involving SLC25A11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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