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Aliases for SLC25A10 Gene

Aliases for SLC25A10 Gene

  • Solute Carrier Family 25 Member 10 2 3 4 5
  • Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate Transporter), Member 10 2 3
  • DIC 3 4
  • Mitochondrial Dicarboxylate Carrier 3
  • Dicarboxylate Ion Carrier 3

External Ids for SLC25A10 Gene

Previous HGNC Symbols for SLC25A10 Gene

  • DIC

Previous GeneCards Identifiers for SLC25A10 Gene

  • GC17U990019
  • GC17P080239
  • GC17P080375
  • GC17P077289
  • GC17P079679
  • GC17P075125
  • GC17P079674

Summaries for SLC25A10 Gene

Entrez Gene Summary for SLC25A10 Gene

  • This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for SLC25A10 Gene

SLC25A10 (Solute Carrier Family 25 Member 10) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metabolism. GO annotations related to this gene include antiporter activity and phosphate ion transmembrane transporter activity. An important paralog of this gene is ENSG00000262660.

UniProtKB/Swiss-Prot for SLC25A10 Gene

  • Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Gene Wiki entry for SLC25A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A10 Gene

Genomics for SLC25A10 Gene

Regulatory Elements for SLC25A10 Gene

Enhancers for SLC25A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F081990 1.6 FANTOM5 Ensembl ENCODE 7 +279.6 279611 2.9 MLX ZFP64 ARID4B DMAP1 ZNF48 BRCA1 ZNF121 SLC30A9 PAF1 SP5 ENSG00000262049 ASPSCR1 GPS1 CEP131 ENSG00000265678 ARL16 RFNG ENSG00000262877 SLC25A10 DCXR
GH17F082095 1.6 FANTOM5 ENCODE 1.6 +389.2 389241 12.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CCDC57 NPLOC4 LOC105371942 ARL16 ENSG00000262877 TSPAN10 ARL2BPP9 ALYREF ENSG00000262049 CEP131
GH17F082094 0.6 FANTOM5 1.8 +382.7 382656 0.1 POLR2A SMAD5 FASN DUS1L SLC25A10 PCYT2 ASPSCR1 DCXR LRRC45 FOXK2 GCGR MRPL12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A10 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001810551 264 1801 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207
ENSR00001355401 1564 401 MLX ARID4B DMAP1 THRB ZNF48 ZSCAN9 RAD21 RARA YY1 SLC30A9

Genomic Location for SLC25A10 Gene

Chromosome:
17
Start:
81,712,236 bp from pter
End:
81,721,016 bp from pter
Size:
8,781 bases
Orientation:
Plus strand

Genomic View for SLC25A10 Gene

Genes around SLC25A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A10 Gene

Proteins for SLC25A10 Gene

  • Protein details for SLC25A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBX3-DIC_HUMAN
    Recommended name:
    Mitochondrial dicarboxylate carrier
    Protein Accession:
    Q9UBX3
    Secondary Accessions:
    • Q542Z3
    • Q96BA1
    • Q96IP1

    Protein attributes for SLC25A10 Gene

    Size:
    287 amino acids
    Molecular mass:
    31282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A10 Gene

Post-translational modifications for SLC25A10 Gene

  • Ubiquitination at Lys 254
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A10 Gene

No data available for DME Specific Peptides for SLC25A10 Gene

Domains & Families for SLC25A10 Gene

Gene Families for SLC25A10 Gene

Protein Domains for SLC25A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBX3

UniProtKB/Swiss-Prot:

DIC_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A10: view

Function for SLC25A10 Gene

Molecular function for SLC25A10 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Gene Ontology (GO) - Molecular Function for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005310 dicarboxylic acid transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 19060904
GO:0015114 phosphate ion transmembrane transporter activity IEA --
GO:0015116 sulfate transmembrane transporter activity IEA --
GO:0015117 thiosulfate transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC25A10: view
genes like me logo Genes that share phenotypes with SLC25A10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A10

miRNA for SLC25A10 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A10 Gene

Localization for SLC25A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A10 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A10 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A10: view

Pathways & Interactions for SLC25A10 Gene

genes like me logo Genes that share pathways with SLC25A10: view

Pathways by source for SLC25A10 Gene

Gene Ontology (GO) - Biological Process for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis TAS --
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006817 phosphate ion transport IEA --
GO:0006835 dicarboxylic acid transport TAS 9733776
genes like me logo Genes that share ontologies with SLC25A10: view

No data available for SIGNOR curated interactions for SLC25A10 Gene

Drugs & Compounds for SLC25A10 Gene

(1) Drugs for SLC25A10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with SLC25A10: view

Transcripts for SLC25A10 Gene

Unigene Clusters for SLC25A10 Gene

Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: - -

Relevant External Links for SLC25A10 Gene

GeneLoc Exon Structure for
SLC25A10
ECgene alternative splicing isoforms for
SLC25A10

Expression for SLC25A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC25A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A10 Gene

This gene is overexpressed in Liver (x6.1) and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for SLC25A10 Gene

This gene is overexpressed in Nasal epithelium (45.0) and Gallbladder (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A10 Gene



Protein tissue co-expression partners for SLC25A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A10 Gene:

SLC25A10

SOURCE GeneReport for Unigene cluster for SLC25A10 Gene:

Hs.548187

mRNA Expression by UniProt/SwissProt for SLC25A10 Gene:

Q9UBX3-DIC_HUMAN
Tissue specificity: Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.
genes like me logo Genes that share expression patterns with SLC25A10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC25A10 Gene

Orthologs for SLC25A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A10 34
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia SLC25A10 34
  • 88.4 (n)
-- 35
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc25a10 34 16 35
  • 86.55 (n)
cow
(Bos Taurus)
Mammalia SLC25A10 34
  • 86.37 (n)
MRPL12 35
  • 55 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc25a10 34
  • 84.8 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC25A10 34
  • 81.16 (n)
-- 35
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a10 34
  • 71.58 (n)
Str.15496 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11739 34
zebrafish
(Danio rerio)
Actinopterygii CABZ01059390.1 35
  • 77 (a)
ManyToMany
si:ch1073-100f3.2 35
  • 77 (a)
ManyToMany
LOC100332610 34
  • 71.99 (n)
zgc56614 34
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH02431 36
  • 58 (a)
CG4323 36
  • 51 (a)
Dic3 35
  • 46 (a)
ManyToMany
CG11196 36
  • 45 (a)
CG18363 36
  • 38 (a)
CG6893 35
  • 37 (a)
ManyToMany
Dic4 35
  • 36 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003073 34
  • 57.94 (n)
worm
(Caenorhabditis elegans)
Secernentea K11G12.5 36 35
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 34 35 37
  • 47.83 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01514 34
  • 53.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2426 35
  • 53 (a)
OneToMany
Species where no ortholog for SLC25A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A10 Gene

ENSEMBL:
Gene Tree for SLC25A10 (if available)
TreeFam:
Gene Tree for SLC25A10 (if available)

Paralogs for SLC25A10 Gene

(10) SIMAP similar genes for SLC25A10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC25A10: view

Variants for SLC25A10 Gene

Sequence variations from dbSNP and Humsavar for SLC25A10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111499289 -- 81,718,914(+) ACTGC(A/C)CTCCA intron-variant
rs11150813 -- 81,720,188(+) CACCC(A/G)TCCTC reference, missense, utr-variant-3-prime
rs111639655 -- 81,719,487(+) TTGCA(A/G)AGCCC intron-variant
rs112032635 -- 81,712,724(+) GGGCG(C/T)AGCCG intron-variant
rs112082309 -- 81,720,111(+) GCCAG(A/C)CACGC reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC25A10 Gene

Variant ID Type Subtype PubMed ID
nsv952390 CNV deletion 24416366
nsv828128 CNV loss 20364138
nsv470620 CNV loss 18288195
nsv428351 CNV gain 18775914
esv26223 CNV gain+loss 19812545

Variation tolerance for SLC25A10 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC25A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A10 Gene

Disorders for SLC25A10 Gene

Relevant External Links for SLC25A10

Genetic Association Database (GAD)
SLC25A10
Human Genome Epidemiology (HuGE) Navigator
SLC25A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A10

No disorders were found for SLC25A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A10 Gene

Publications for SLC25A10 Gene

  1. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. (PMID: 10585886) Fiermonte G. … Palmieri F. (Biochem. J. 1999) 3 4 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. (PMID: 16027120) Mizuarai S. … Kotani H. (J. Biol. Chem. 2005) 3 25 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLC25A10 Gene

Sources for SLC25A10 Gene

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