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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A10 Gene

protein-coding   GIFtS: 60
GCID: GC17P079674

Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate...


(Previous symbol: DIC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate
Transporter), Member 101 2
DIC1 2 3 5
Dicarboxylate Ion Carrier2
Mitochondrial Dicarboxylate Carrier2
Solute Carrier Family 25 Member 103

External Ids:    HGNC: 109801   Entrez Gene: 14682   Ensembl: ENSG000001830487   OMIM: 6067945   UniProtKB: Q9UBX33   

Export aliases for SLC25A10 gene to outside databases

Previous GC identifers: GC17U990019 GC17P080239 GC17P080375 GC17P077289 GC17P079679 GC17P075125


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC25A10 Gene:
This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial
membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and
other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty
acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Aug 2012)

GeneCards Summary for SLC25A10 Gene: 
SLC25A10 (solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10) is a protein-coding gene. Diseases associated with SLC25A10 include clivus chordoma, and breast malignant phyllodes tumor, and among its related super-pathways are Amino acid transport across the plasma membrane and Sulfide oxidation to sulfate. GO annotations related to this gene include protein binding and dicarboxylic acid transmembrane transporter activity. An important paralog of this gene is UCP3.

UniProtKB/Swiss-Prot: DIC_HUMAN, Q9UBX3
Function: Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite
or thiosulfate across mitochondrial inner membrane

Gene Wiki entry for SLC25A10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A10 gene promoter:
         NRSF form 1   AP-4   Nkx2-5   LCR-F1   NRSF form 2   Roaz   HEN1   RORalpha1   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

SLC25A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079674:  view genomic region     (about GC identifiers)

Start:
79,670,404 bp from pter      End:
79,688,042 bp from pter
Size:
17,639 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DIC_HUMAN, Q9UBX3 (See protein sequence)
Recommended Name: Mitochondrial dicarboxylate carrier  
Size: 287 amino acids; 31282 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: Q542Z3 Q96BA1 Q96IP1
Alternative splicing: 2 isoforms:  Q9UBX3-1   Q9UBX3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC25A10: NX_Q9UBX3

Explore proteomics data for SLC25A10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBX3

  • SLC25A10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC25A10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001257817.1  NP_001257882.1  NP_036272.2  

    ENSEMBL proteins: 
     ENSP00000460597   ENSP00000328403   ENSP00000345580   ENSP00000458785   ENSP00000439565  
     ENSP00000446242  
    Reactome Protein details: Q9UBX3
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    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--

    SLC25A10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial dicarboxylate transporter 
    Mitochondrial di- and tri-carboxylic acid transporters

    3 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR002030 Mit_uncoupling
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9UBX3

    ProtoNet protein and cluster: Q9UBX3

    UniProtKB/Swiss-Prot: DIC_HUMAN, Q9UBX3
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    SLC25A10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DIC_HUMAN, Q9UBX3
    Function: Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite
    or thiosulfate across mitochondrial inner membrane

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome ----
    GO:0005310dicarboxylic acid transmembrane transporter activity TAS9733776
    GO:0005515protein binding IPI19060904
    GO:0015114phosphate ion transmembrane transporter activity IEA--
    GO:0015116sulfate transmembrane transporter activity IEA--
         
    SLC25A10 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC25A10 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Amino acid and oligopeptide SLC transporters
    Amino acid and oligopeptide SLC transporters0.63
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    2Degradation of cysteine and homocysteine
    Degradation of cysteine and homocysteine0.62
    Sulfide oxidation to sulfate0.62
    3SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    4Glucose metabolism
    Glucose metabolism0.50
    Gluconeogenesis0.50
    5MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/13        Reactome Pathways for SLC25A10 (see all 13)
        Sulfide oxidation to sulfate
    Metabolism of carbohydrates
    Metabolism
    Sulfur amino acid metabolism
    Gluconeogenesis


    1         Kegg Pathway  (Kegg details for SLC25A10):
        Proximal tubule bicarbonate reclamation


    SLC25A10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/270 Interacting proteins for SLC25A10 (Q9UBX31, 2, 3 ENSP000003455804) via UniProtKB, MINT, STRING, and/or I2D (see all 270)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-67782 I2D: score=5 STRING: ENSP00000377582
    ATP5A1P257052, 3MINT-8079030 I2D: score=1 
    UQCRFS1P479852, 3MINT-8079030 I2D: score=1 
    MDFIQ997501, 3, ENSP000002303214EBI-750394,EBI-724076 I2D: score=3 STRING: ENSP00000230321
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0000098sulfur amino acid catabolic process TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--

    SLC25A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC25A10 (DIC)

    1 HMDB Compound for SLC25A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Succinic acid1,2-Ethanedicarboxylate (see all 11)110-15-6--

    1 DrugBank Compound for SLC25A10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Succinic acid1,2-Ethanedicarboxylic acid (see all 8)110-15-6target--16176879 16027120

    Search CenterWatch for drugs/clinical trials and news about SLC25A10 / DIC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC25A10 gene (3 alternative transcripts): 
    NM_001270888.1  NM_001270953.1  NM_012140.4  

    Unigene Cluster for SLC25A10:

    Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
    Hs.548187  [show with all ESTs]
    Unigene Representative Sequence: NM_001270888
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574129 ENST00000331531(uc010dif.3) ENST00000350690(uc002kbi.3 uc010wuu.2)
    ENST00000574884 ENST00000571876 ENST00000570310 ENST00000573246 ENST00000541223
    ENST00000545862
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    Additional mRNA sequence: 

    AJ131613.1 AK075249.1 AK303808.1 BC007355.2 BC015797.1 

    7 DOTS entries:

    DT.208213  DT.100760785  DT.92435440  DT.92059979  DT.95239687  DT.100747064  DT.97845473 

    24/185 AceView cDNA sequences (see all 185):

    BQ065993 NM_012140 BQ943394 CB111910 BI226141 AI972040 BQ920816 BF058424 
    BM470204 AI469842 BM129729 AI373475 BM851347 AW513012 BU521866 BC007355 
    AW246762 CK431149 BE272036 BF476113 BG470572 BM126548 BM561945 BX456010 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A10 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c
    SP1:                    -     -                             -     -           -                             -                                             
    SP2:                    -     -                             -     -           -                             -     -                                       
    SP3:                    -     -                             -     -           -                                                                           
    SP4:                                                        -     -           -                             -     -                                       
    SP5:                    -     -                             -     -           -                       -     -     -                                       


    ECgene alternative splicing isoforms for SLC25A10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A10 expression in normal human tissues (normalized intensities)      SLC25A10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCGGGCA
    SLC25A10 Expression
    About this image


    SLC25A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See SLC25A10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC25A10

    SOURCE GeneReport for Unigene cluster: Hs.548187

    UniProtKB/Swiss-Prot: DIC_HUMAN, Q9UBX3
    Tissue specificity: Present in high amounts in liver and kidney, and at lower levels in all the other tissues
    analyzed

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC25A10: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC25A10 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a101 , 5 solute carrier family 25 (mitochondrial carrier, dicarboxylate more1, 5 86.55(n)1
    90.18(a)1
      11 (84.19 cM)5
    273761  NM_013770.21  NP_038798.21 
     1204918405 
    chicken
    (Gallus gallus)
    Aves SLC25A101 solute carrier family 25 (mitochondrial carrier; dicarboxylate more 81.63(n)
    86.57(a)
      769048  XM_001232237.2  XP_001232238.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    84(a)
    1 → many
    2(118760589-118776177)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.117392 Xenopus laevis transcribed sequence with weak similarity more 77(n)    BX846152.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc566142 similar to solute carrier family 25 (mitochondrial more 76.56(n)   394147  BC049505.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH024313
    Dic11
    carrier3
    Dicarboxylate carrier 11
    58(a)
    (best of 4)3
    58.33(n)1
    59.78(a)1
      87E83
    416401  NM_142022.31  NP_650279.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K11G12.51 , 3 mitochondrial 2-oxoglutartae3
    Protein K11G12.51
    59(a)3
    57.95(n)1
    59.86(a)1
      X(6759255-6760923)3
    1809401  NM_076732.41  NP_509133.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIC1(YLR348C)4
    DIC11
    Mitochondrial dicarboxylate carrier, integral membrane more4
    Dic1p1
    47.71(n)1
    41.26(a)1
      12(827873-826977)4
    8510631, 4  NP_013452.11, 4 


    ENSEMBL Gene Tree for SLC25A10 (if available)
    TreeFam Gene Tree for SLC25A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A10 gene
    UCP32  UCP12  UCP22  SLC25A142  SLC25A112  ENSG000002626602  SLC25A302  SLC25A272  
    10 SIMAP similar genes for SLC25A10 using alignment to 5 protein entries:     DIC_HUMAN (see all proteins):
    MRPL12    MRPL7/L12    SLC25A11    UCP2    UCP1    SLC25A14
    SLC25A30    SLC25A27    UCP3    SLC25A34

    SLC25A10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/322 SNPs in SLC25A10 are shown (see all 322)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895232811,2
    --79677327(+) TGTGGG/TTTGGG 3 -- us2k10--------
    rs1495607401,2
    --79677359(+) TTCAGC/TCCTGT 3 -- us2k10--------
    rs1148458061,2
    C,F--79677370(+) CTTGCA/GGGTGG 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs794693561,2
    F--79677536(+) CATCTC/TGGTTT 3 -- us2k11Minor allele frequency- T:0.04WA 118
    rs353876851,2
    C,F--79677583(+) TCTGCG/AGGACT 3 -- us2k16Minor allele frequency- A:0.11NA CSA WA EA 364
    rs754942581,2
    F--79677638(+) CTCTTG/TCTGGG 3 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1832730481,2
    C--79677670(+) CACTTC/TCCCTG 3 -- us2k10--------
    rs65656241,2
    C,F,A,H--79677750(+) TGCATT/CTGCGC 3 -- us2k122Minor allele frequency- C:0.31NS EA NA WA CSA 2353
    rs791939691,2
    C--79677792(+) AGGCTC/TGGTGC 3 -- us2k10--------
    rs72174521,2
    C,F--79677797(+) TGGTGC/TGGGCA 3 -- us2k14Minor allele frequency- T:0.21NA WA 124

    HapMap Linkage Disequilibrium report for SLC25A10 (79670404 - 79688042 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for SLC25A10 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3335n71CNV Loss21882294
    nsv909116CNV Loss21882294
    nsv909126CNV Loss21882294
    dgv3330n71CNV Loss21882294
    nsv909127CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv828128CNV Loss20364138
    nsv909109CNV Loss21882294
    nsv909052CNV Loss21882294
    dgv3334n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606794    OMIM disorders: --

    14 diseases for SLC25A10:    About MalaCards
    clivus chordoma    breast malignant phyllodes tumor    patau syndrome    phyllode tumor
    edwards syndrome    gonadoblastoma    amenorrhea    turner syndrome
    chordoma    retinitis pigmentosa    herpes simplex    down syndrome
    retinitis    pancreatitis


    SLC25A10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC25A10
    Human Genome Epidemiology (HuGE) Navigator: SLC25A10 (1 document)

    Export disorders for SLC25A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A10 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with SLC25A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. (PubMed id 10585886)1, 2, 9 Fiermonte G....Palmieri F. (1999)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. (PubMed id 16027120)1, 7 Mizuarai S....Kotani H. (2005)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3. (PubMed id 10072589)1, 3 Pannone E....Palmieri F. (1998)
    7. The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. (PubMed id 9733776)1, 3 Fiermonte G....Walker J.E. (1998)
    8. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (2013)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. The mitochondrial transporter family SLC25: identifica tion, properties and physiopathology. (PubMed id 23266187)1 Palmieri F. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1468 HGNC: 10980 AceView: SLC25A10 Ensembl:ENSG00000183048 euGenes: HUgn1468
    ECgene: SLC25A10 Kegg: 1468 H-InvDB: SLC25A10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC25A10 gene:
    Search GeneIP for patents involving SLC25A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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