Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC25A10 Gene

protein-coding   GIFtS: 61
GCID: GC17P079674

Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate...


(Previous symbol: DIC)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate
Transporter), Member 101 2
DIC1 2 3 5
Dicarboxylate Ion Carrier2
Mitochondrial Dicarboxylate Carrier2
Solute Carrier Family 25 Member 103

External Ids:    HGNC: 109801   Entrez Gene: 14682   Ensembl: ENSG000001830487   OMIM: 6067945   UniProtKB: Q9UBX33   

Export aliases for SLC25A10 gene to outside databases

Previous GC identifers: GC17U990019 GC17P080239 GC17P080375 GC17P077289 GC17P079679 GC17P075125


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC25A10 Gene:
This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial
membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and
other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty
acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Aug 2012)

GeneCards Summary for SLC25A10 Gene:
SLC25A10 (solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10) is a protein-coding gene. GO annotations related to this gene include antiporter activity and phosphate ion transmembrane transporter activity. An important paralog of this gene is UCP3.

UniProtKB/Swiss-Prot: DIC_HUMAN, Q9UBX3
Function: Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite
or thiosulfate across mitochondrial inner membrane

Gene Wiki entry for SLC25A10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC25A10 gene promoter:
         NRSF form 1   AP-4   Nkx2-5   LCR-F1   NRSF form 2   Roaz   HEN1   RORalpha1   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC25A10 promoter sequence
   Search Chromatin IP Primers for SLC25A10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

SLC25A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079674:  view genomic region     (about GC identifiers)

Start:
79,670,404 bp from pter      End:
79,688,042 bp from pter
Size:
17,639 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DIC_HUMAN, Q9UBX3 (See protein sequence)
Recommended Name: Mitochondrial dicarboxylate carrier  
Size: 287 amino acids; 31282 Da
Secondary accessions: Q542Z3 Q96BA1 Q96IP1
Alternative splicing: 2 isoforms:  Q9UBX3-1   Q9UBX3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC25A10: NX_Q9UBX3

Explore proteomics data for SLC25A10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys254
  • Modification sites at PhosphoSitePlus

  • See SLC25A10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257817.1  NP_001257882.1  NP_036272.2  

    ENSEMBL proteins: 
     ENSP00000460597   ENSP00000328403   ENSP00000345580   ENSP00000458785   ENSP00000439565  
     ENSP00000446242  
    Reactome Protein details: Q9UBX3

    SLC25A10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC25A10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC25A10
    GenScript Custom Purified and Recombinant Proteins Services for SLC25A10
    Novus Biologicals SLC25A10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC25A10 

    SLC25A10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC25A10
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC25A10
    Novus Biologicals SLC25A10 Antibodies
    Search for Antibodies for SLC25A10 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SLC25A10
    LSBio Antibodies in human, mouse, rat for SLC25A10

    SLC25A10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC25A10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC25A10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC25A10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial dicarboxylate transporter
    Mitochondrial di- and tri-carboxylic acid transporters

    3 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR002030 Mit_uncoupling
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9UBX3

    ProtoNet protein and cluster: Q9UBX3

    UniProtKB/Swiss-Prot: DIC_HUMAN, Q9UBX3
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    Find genes that share domains with SLC25A10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DIC_HUMAN, Q9UBX3
    Function: Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite
    or thiosulfate across mitochondrial inner membrane

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome ----
    GO:0005310dicarboxylic acid transmembrane transporter activity TAS9733776
    GO:0005515protein binding IPI19060904
    GO:0015114phosphate ion transmembrane transporter activity ----
    GO:0015116sulfate transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC25A10           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC25A10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC25A10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC25A10

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC25A10:
    hsa-mir-1 (MIRT023781), hsa-mir-222-3p (MIRT046668), hsa-mir-193b-3p (MIRT041535)

    Block miRNA regulation of human, mouse, rat SLC25A10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC25A10:
    hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC25A10
    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC25A10

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC25A10 (see all 6)
    OriGene ORF clones in mouse, rat for SLC25A10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC25A10 (NM_012140)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC25A10
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC25A10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DIC_HUMAN, Q9UBX3: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    cytosol1
    endoplasmic reticulum1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005840ribosome ----

    Find genes that share ontologies with SLC25A10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC25A10 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Organic anion transporters0.00
    2Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Sulfide oxidation to sulfate0.00
    Degradation of cysteine and homocysteine0.00
    3Glucose metabolism
    Glucose metabolism0.44
    Gluconeogenesis0.44
    4MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with SLC25A10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SLC25A10
        Sulfide oxidation to sulfate
    Gluconeogenesis
    Organic anion transporters


    1 Kegg Pathway  (Kegg details for SLC25A10):
        Proximal tubule bicarbonate reclamation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC25A10: 
              Mitochondrial Energy Metabolism in human mouse rat
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC25A10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC25A10 (Q9UBX31, 2, 3 ENSP000003455804) via UniProtKB, MINT, STRING, and/or I2D (see all 279)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-67782 I2D: score=5 STRING: ENSP00000377582
    ATP5A1P257052, 3MINT-8079030 I2D: score=1 
    UQCRFS1P479852, 3MINT-8079030 I2D: score=1 
    MDFIQ997501, 3, ENSP000002303214EBI-750394,EBI-724076 I2D: score=3 STRING: ENSP00000230321
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0000098sulfur amino acid catabolic process TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--

    Find genes that share ontologies with SLC25A10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC25A10 (DIC)

    1 HMDB Compound for SLC25A10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Succinic acid1,2-Ethanedicarboxylate (see all 11)110-15-6--

    1 DrugBank Compound for SLC25A10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Succinic acid1,2-Ethanedicarboxylic acid (see all 8)110-15-6target--16176879 16027120



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC25A10 gene (3 alternative transcripts): 
    NM_001270888.1  NM_001270953.1  NM_012140.4  

    Unigene Cluster for SLC25A10:

    Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
    Hs.548187  [show with all ESTs]
    Unigene Representative Sequence: NM_001270888
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574129 ENST00000331531(uc010dif.3) ENST00000350690(uc002kbi.3 uc010wuu.2)
    ENST00000574884 ENST00000571876 ENST00000570310 ENST00000573246 ENST00000541223
    ENST00000545862
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC25A10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC25A10:
    hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidSLC25A10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC25A10
    Predesigned siRNA for gene silencing in human, mouse, rat SLC25A10
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC25A10 (see all 6)
    OriGene ORF clones in mouse, rat for SLC25A10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC25A10 (NM_012140)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC25A10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC25A10
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A10
      QuantiTect SYBR Green Assays in human, mouse, rat SLC25A10
      QuantiFast Probe-based Assays in human, mouse, rat SLC25A10

    Additional mRNA sequence: 

    AJ131613.1 AK075249.1 AK303808.1 BC007355.2 BC015797.1 

    7 DOTS entries:

    DT.208213  DT.100760785  DT.92435440  DT.92059979  DT.95239687  DT.100747064  DT.97845473 

    Selected AceView cDNA sequences (see all 185):

    AW246762 BF058424 NM_012140 AI972040 BQ065993 AI469842 BM470204 CK431149 
    BM129729 BQ920816 BC007355 BM851347 BE272036 AI373475 BI226141 CB111910 
    AW513012 BU521866 BF476113 BQ943394 BU176451 BG703609 AL565392 AI926040 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A10 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c
    SP1:                    -     -                             -     -           -                             -                                             
    SP2:                    -     -                             -     -           -                             -     -                                       
    SP3:                    -     -                             -     -           -                                                                           
    SP4:                                                        -     -           -                             -     -                                       
    SP5:                    -     -                             -     -           -                       -     -     -                                       


    ECgene alternative splicing isoforms for SLC25A10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC25A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCGGGCA
    SLC25A10 Expression
    About this image


    SLC25A10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SLC25A10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC25A10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.548187

    UniProtKB/Swiss-Prot: DIC_HUMAN, Q9UBX3
    Tissue specificity: Present in high amounts in liver and kidney, and at lower levels in all the other tissues
    analyzed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC25A10: 
              Mitochondrial Energy Metabolism in human mouse rat
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC25A10
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A10
    QuantiTect SYBR Green Assays in human, mouse, rat SLC25A10
    QuantiFast Probe-based Assays in human, mouse, rat SLC25A10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC25A10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc25a101 , 5 solute carrier family 25 (mitochondrial carrier, dicarboxylate more1, 5 86.55(n)1
    90.18(a)1
      11 (84.19 cM)5
    273761  NM_013770.21  NP_038798.21 
     1204918405 
    chicken
    (Gallus gallus)
    Aves SLC25A101 solute carrier family 25 (mitochondrial carrier; dicarboxylate more 81.16(n)
    85.96(a)
      769048  XM_001232237.3  XP_001232238.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    84(a)
    1 → many
    2(118760589-118776177)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.117392 Xenopus laevis transcribed sequence with weak similarity more 77(n)    BX846152.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc566142 similar to solute carrier family 25 (mitochondrial more 76.56(n)   394147  BC049505.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH024313 carrier 58(a)
    (best of 4)
      87E8   --
    worm
    (Caenorhabditis elegans)
    Secernentea K11G12.53 mitochondrial 2-oxoglutartae 59(a)   X(6759255-6760923)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIC1(YLR348C)4
    DIC11
    Mitochondrial dicarboxylate carrier, integral membrane more4
    DIC11
    47.83(n)1
    41.26(a)1
      12(827873-826977)4
    8510631, 4  NP_013452.11, 4 


    ENSEMBL Gene Tree for SLC25A10 (if available)
    TreeFam Gene Tree for SLC25A10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC25A10 gene
    UCP32  UCP12  UCP22  SLC25A142  SLC25A112  ENSG000002626602  SLC25A302  SLC25A272  
    10 SIMAP similar genes for SLC25A10 using alignment to 5 protein entries:     DIC_HUMAN (see all proteins):
    MRPL12    MRPL7/L12    SLC25A11    UCP2    UCP1    SLC25A14
    SLC25A30    SLC25A27    UCP3    SLC25A34

    Find genes that share paralogs with SLC25A10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC25A10 (see all 322)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895232811,2
    --79677327(+) TGTGGG/TTTGGG 3 -- us2k10--------
    rs1495607401,2
    --79677359(+) TTCAGC/TCCTGT 3 -- us2k10--------
    rs1148458061,2
    C,F--79677370(+) CTTGCA/GGGTGG 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs794693561,2
    F--79677536(+) CATCTC/TGGTTT 3 -- us2k11Minor allele frequency- T:0.04WA 118
    rs353876851,2
    C,F--79677583(+) TCTGCG/AGGACT 3 -- us2k16Minor allele frequency- A:0.11NA CSA WA EA 364
    rs754942581,2
    F--79677638(+) CTCTTG/TCTGGG 3 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1832730481,2
    C--79677670(+) CACTTC/TCCCTG 3 -- us2k10--------
    rs65656241,2
    C,F,A,H--79677750(+) TGCATT/CTGCGC 3 -- us2k122Minor allele frequency- C:0.31NS EA NA WA CSA 2353
    rs791939691,2
    C--79677792(+) AGGCTC/TGGTGC 3 -- us2k10--------
    rs72174521,2
    C,F--79677797(+) TGGTGC/TGGGCA 3 -- us2k14Minor allele frequency- T:0.21NA WA 124

    HapMap Linkage Disequilibrium report for SLC25A10 (79670404 - 79688042 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC25A10 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3335n71CNV Loss21882294
    nsv909116CNV Loss21882294
    nsv909126CNV Loss21882294
    dgv3330n71CNV Loss21882294
    nsv909127CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv828128CNV Loss20364138
    nsv909109CNV Loss21882294
    nsv909052CNV Loss21882294
    dgv3334n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC25A10
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC25A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606794    OMIM disorders: --


    Find genes that share disorders with SLC25A10           About GenesLikeMe

    Genetic Association Database (GAD): SLC25A10
    Human Genome Epidemiology (HuGE) Navigator: SLC25A10 (1 document)

    Export disorders for SLC25A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC25A10 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with SLC25A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. (PubMed id 10585886)1, 2, 9 Fiermonte G....Palmieri F. (Biochem. J. 1999)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. (PubMed id 16027120)1, 7 Mizuarai S....Kotani H. (J. Biol. Chem. 2005)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3. (PubMed id 10072589)1, 3 Pannone E....Palmieri F. (Cytogenet. Cell Genet. 1998)
    7. The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. (PubMed id 9733776)1, 3 Fiermonte G....Walker J.E. (J. Biol. Chem. 1998)
    8. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1468 HGNC: 10980 AceView: SLC25A10 Ensembl:ENSG00000183048 euGenes: HUgn1468
    ECgene: SLC25A10 Kegg: 1468 H-InvDB: SLC25A10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC25A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC25A10 gene:
    Search GeneIP for patents involving SLC25A10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC25A10
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC25A10  
     OriGene qPCR primer pairs and template standards for SLC25A10   OriGene Protein Over-expression Lysate for SLC25A10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC25A10  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC25A10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC25A10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC25A10   OriGene Custom Protein Services for SLC25A10  

     
     
     Block miRNA regulation of human, mouse, rat SLC25A10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC25A10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC25A10 Predesigned siRNA for gene silencing in human, mouse, rat SLC25A10
     QuantiFast Probe-based Assays in human, mouse, rat SLC25A10 QuantiTect SYBR Green Assays in human, mouse, rat SLC25A10
     PCR Arrays including human, mouse, rat SLC25A10 Search Chromatin IP Primers for SLC25A10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC25A10  Search GeneGlobe Interaction Network for SLC25A10
     Regulatory tfbs in SLC25A10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC25A10 GenScript cDNA clones with any tag delivered in your preferred vector for SLC25A10
     GenScript Custom Assay Services for SLC25A10 GenScript Custom overexpressing Cell Line Services for SLC25A10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC25A10 (DIC)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC25A10 antibodies
     SLC25A10 lysates
     Search for Antibodies for SLC25A10 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC25A10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC25A10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC25A10
     SwitchGear 3'UTR luciferase reporter plasmids for SLC25A10
     SwitchGear Promoter luciferase reporter plasmids for SLC25A10
     ThermoFisher Antibodies for SLC25A10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC25A10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC25A10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC25A10
     LSBio Antibodies in human, mouse, rat for SLC25A10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC25A10
      Search eBioscience for proteins for SLC25A10
      Search eBioscience for elisas for SLC25A10
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC25A10 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4