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Aliases for SLC25A10 Gene

Aliases for SLC25A10 Gene

  • Solute Carrier Family 25 Member 10 2 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate Transporter), Member 10 2 3
  • DIC 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier Dicarboxylate Transporter), Member 10 5
  • Dicarboxylate Ion Carrier 3

External Ids for SLC25A10 Gene

Previous HGNC Symbols for SLC25A10 Gene

  • DIC

Previous GeneCards Identifiers for SLC25A10 Gene

  • GC17U990019
  • GC17P080239
  • GC17P080375
  • GC17P077289
  • GC17P079679
  • GC17P075125
  • GC17P079674

Summaries for SLC25A10 Gene

Entrez Gene Summary for SLC25A10 Gene

  • This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for SLC25A10 Gene

SLC25A10 (Solute Carrier Family 25 Member 10) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include antiporter activity and phosphate ion transmembrane transporter activity. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for SLC25A10 Gene

  • Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Gene Wiki entry for SLC25A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A10 Gene

Genomics for SLC25A10 Gene

Regulatory Elements for SLC25A10 Gene

Promoters for SLC25A10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC25A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC25A10 Gene

Chromosome:
17
Start:
81,712,236 bp from pter
End:
81,721,016 bp from pter
Size:
8,781 bases
Orientation:
Plus strand

Genomic View for SLC25A10 Gene

Genes around SLC25A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A10 Gene

Proteins for SLC25A10 Gene

  • Protein details for SLC25A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBX3-DIC_HUMAN
    Recommended name:
    Mitochondrial dicarboxylate carrier
    Protein Accession:
    Q9UBX3
    Secondary Accessions:
    • Q542Z3
    • Q96BA1
    • Q96IP1

    Protein attributes for SLC25A10 Gene

    Size:
    287 amino acids
    Molecular mass:
    31282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A10 Gene

Proteomics data for SLC25A10 Gene at MOPED

Post-translational modifications for SLC25A10 Gene

  • Ubiquitination at Lys 254
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A10 Gene

Antibody Products

No data available for DME Specific Peptides for SLC25A10 Gene

Domains & Families for SLC25A10 Gene

Gene Families for SLC25A10 Gene

Protein Domains for SLC25A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBX3

UniProtKB/Swiss-Prot:

DIC_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A10: view

Function for SLC25A10 Gene

Molecular function for SLC25A10 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
genes like me logo Genes that share phenotypes with SLC25A10: view

Animal Model Products

CRISPR Products

miRNA for SLC25A10 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A10 Gene

Localization for SLC25A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A10 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A10 Gene COMPARTMENTS Subcellular localization image for SLC25A10 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SLC25A10 Gene

Pathways & Interactions for SLC25A10 Gene

genes like me logo Genes that share pathways with SLC25A10: view

Gene Ontology (GO) - Biological Process for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006412 translation IBA --
GO:0006811 ion transport TAS --
genes like me logo Genes that share ontologies with SLC25A10: view

No data available for SIGNOR curated interactions for SLC25A10 Gene

Drugs & Compounds for SLC25A10 Gene

(1) Drugs for SLC25A10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with SLC25A10: view

Transcripts for SLC25A10 Gene

Unigene Clusters for SLC25A10 Gene

Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: - -

Relevant External Links for SLC25A10 Gene

GeneLoc Exon Structure for
SLC25A10
ECgene alternative splicing isoforms for
SLC25A10

Expression for SLC25A10 Gene

mRNA expression in normal human tissues for SLC25A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A10 Gene

This gene is overexpressed in Liver (x6.1) and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for SLC25A10 Gene

This gene is overexpressed in Nasal epithelium (45.0) and Gallbladder (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A10 Gene



SOURCE GeneReport for Unigene cluster for SLC25A10 Gene Hs.548187

mRNA Expression by UniProt/SwissProt for SLC25A10 Gene

Q9UBX3-DIC_HUMAN
Tissue specificity: Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.
genes like me logo Genes that share expression patterns with SLC25A10: view

Protein tissue co-expression partners for SLC25A10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC25A10 Gene

Orthologs for SLC25A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC25A10 35
  • 99.21 (n)
  • 98.65 (a)
cow
(Bos Taurus)
Mammalia SLC25A10 35
  • 86.37 (n)
  • 88.51 (a)
MRPL12 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
OneToMany
SLC25A10 35
  • 88.4 (n)
  • 90.2 (a)
mouse
(Mus musculus)
Mammalia Slc25a10 16
Slc25a10 36
  • 90 (a)
OneToMany
Slc25a10 35
  • 86.55 (n)
  • 90.18 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc25a10 35
  • 84.8 (n)
  • 89.47 (a)
chicken
(Gallus gallus)
Aves SLC25A10 35
  • 81.16 (n)
  • 85.96 (a)
-- 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.11739 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a10 35
  • 71.58 (n)
  • 83.16 (a)
Str.15496 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01059390.1 36
  • 77 (a)
ManyToMany
si:ch1073-100f3.2 36
  • 77 (a)
ManyToMany
LOC100332610 35
  • 71.99 (n)
  • 78.12 (a)
zgc56614 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003073 35
  • 57.94 (n)
  • 56.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6893 36
  • 37 (a)
ManyToMany
Dic3 36
  • 46 (a)
ManyToMany
Dic4 36
  • 36 (a)
ManyToMany
BcDNA:GH02431 37
  • 58 (a)
CG11196 37
  • 45 (a)
CG18363 37
  • 38 (a)
CG4323 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea K11G12.5 37
  • 59 (a)
K11G12.5 36
  • 57 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 35
  • 47.83 (n)
  • 41.26 (a)
DIC1 36
  • 35 (a)
OneToMany
DIC1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU01514 35
  • 53.09 (n)
  • 47.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2426 36
  • 53 (a)
OneToMany
Species with no ortholog for SLC25A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A10 Gene

ENSEMBL:
Gene Tree for SLC25A10 (if available)
TreeFam:
Gene Tree for SLC25A10 (if available)

Paralogs for SLC25A10 Gene

(10) SIMAP similar genes for SLC25A10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC25A10: view

Variants for SLC25A10 Gene

Sequence variations from dbSNP and Humsavar for SLC25A10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs13912 -- 81,720,863(-) ACCGC(A/G)GCCCG utr-variant-3-prime
rs1129920 -- 81,720,822(+) CCTGG(A/G)CCCCC utr-variant-3-prime
rs1129921 -- 81,720,830(+) CCCCC(A/G)CTTGG utr-variant-3-prime
rs2072700 -- 81,715,528(+) GACCG(C/T)GTGGC reference, synonymous-codon
rs8067421 -- 81,715,448(+) TGCCC(A/G)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A10 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
nsv909116 CNV Loss 21882294
dgv3334n71 CNV Loss 21882294
dgv3335n71 CNV Loss 21882294
dgv3336n71 CNV Loss 21882294
nsv909126 CNV Loss 21882294
nsv909127 CNV Loss 21882294

Variation tolerance for SLC25A10 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A10 Gene

HapMap Linkage Disequilibrium report
SLC25A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A10 Gene

Disorders for SLC25A10 Gene

Relevant External Links for SLC25A10

Genetic Association Database (GAD)
SLC25A10
Human Genome Epidemiology (HuGE) Navigator
SLC25A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC25A10

No disorders were found for SLC25A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A10 Gene

Publications for SLC25A10 Gene

  1. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. (PMID: 10585886) Fiermonte G. … Palmieri F. (Biochem. J. 1999) 3 4 23 67
  2. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. (PMID: 16027120) Mizuarai S. … Kotani H. (J. Biol. Chem. 2005) 3 25 26
  3. Differential inhibitory effect of long-chain acyl-CoA esters on succinate and glutamate transport into rat liver mitochondria and its possible implications for long-chain fatty acid oxidation defects. (PMID: 16176879) Ventura F.V. … Wanders R.J. (Mol. Genet. Metab. 2005) 25 26
  4. The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. (PMID: 9733776) Fiermonte G. … Walker J.E. (J. Biol. Chem. 1998) 2 3
  5. Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3. (PMID: 10072589) Pannone E. … Palmieri F. (Cytogenet. Cell Genet. 1998) 2 3

Products for SLC25A10 Gene

Sources for SLC25A10 Gene

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