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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC25A1 Gene

protein-coding   GIFtS: 64
GCID: GC22M019163

solute carrier family 25 (mitochondrial carrier; citrate...

(Previous names: solute carrier family 20 (mitochondrial citrate transporter),...)
(Previous symbol: SLC20A3)
 Explore 4 diseases affiliated with
SLC25A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC25A1    

Aliases
for SLC25A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Family 25 (Mitochondrial Carrier; Citrate Transporter),
Member 11 2
     Tricarboxylate Carrier Protein2 3
CTP1 2 3 5     SEA2
SLC20A31 2 3 5     Tricarboxylate Transport Protein, Mitochondrial2
Solute Carrier Family 20 (Mitochondrial Citrate Transporter), Member 31 2     Solute Carrier Family 25 Member 13
Citrate Transport Protein2 3     

External Ids:    HGNC: 109791   Entrez Gene: 65762   Ensembl: ENSG000001000757   OMIM: 1903155   UniProtKB: P530073   
ORGUL members:         
NONCODE:n409332    

Export aliases for SLC25A1 gene to outside databases

Previous GC identifers: GC22M016103 GC22M017537 GC22M002784


Summaries
for SLC25A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC25A1:
The mitochondrial tricarboxylate transporter (also called citrate transport protein, or CTP) is responsible for the
movement of citrate across the mitochondrial inner membrane (Kaplan et al., 1993 (PubMed 8514800)).(supplied by OMIM,
Jan 2011)

UniProtKB/Swiss-Prot: TXTP_HUMAN, P53007
Function: Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a
carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway

Gene Wiki entry for SLC25A1


Genomic Views
for SLC25A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011519.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC25A1 gene promoter:
         AhR   USF1   Sp1   GATA-2   AREB6   FAC1   USF-1   ARP-1   IRF-7A   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC25A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC25A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC25A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11

SLC25A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC25A1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M019163:  view genomic region     (about GC identifiers)

Start:
 19,163,094 bp from pter      End:
 19,166,343 bp from pter
Size:
 3,250 bases      Orientation:
 minus strand

Proteins
for SLC25A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TXTP_HUMAN, P53007 (See protein sequence)
Recommended Name: Tricarboxylate transport protein, mitochondrial precursor  
Size: 311 amino acids; 34013 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: A8K8E8 Q9BSK6

Explore the universe of human proteins at neXtProt for SLC25A1: NX_P53007

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P53007

    • SLC25A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243463.1  NP_005975.1  

    ENSEMBL proteins: 
     ENSP00000215882   ENSP00000401480  
    Reactome Protein details: P53007
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC25A1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC25A1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral to membrane IEA--


    SLC25A1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC25A1

    Protein Domains /
    Families
    for SLC25A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC25A1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002067 Mit_carrier
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry P53007

    ProtoNet protein and cluster: P53007

    UniProtKB/Swiss-Prot: TXTP_HUMAN, P53007
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 3 Solcar repeats


    Function
    for SLC25A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TXTP_HUMAN, P53007
    Function: Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a
    carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway

         Genatlas biochemistry entry for SLC25A1:
    solute carrier family 25 mitochondrial,member A1,citrate transporter,disrupted by ADU breakpoint

    miRNA
    Products:            		miRTarBase miRNAs that target SLC25A1:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC25A1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC25A1 (see all 25):
    hsa-miR-3673 hsa-miR-10b hsa-miR-331-3p hsa-miR-1271 hsa-miR-339-5p hsa-miR-650 hsa-miR-3190 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: SLC25A1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SLC25A1
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SLC25A1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015137citrate transmembrane transporter activity TAS8666394


    SLC25A1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC25A1:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for SLC25A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucose metabolism
    		Glucose metabolism1.00
    		Gluconeogenesis0.50
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3Fatty Acyl-CoA Biosynthesis
    		Fatty Acyl-CoA Biosynthesis1.00
    		Triglyceride Biosynthesis0.47
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    5MPS IIIC - Sanfilippo syndrome C
    		Metabolism of carbohydrates0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for SLC25A1 (see all 8)
        Metabolism of carbohydrates
    Metabolism
    Triglyceride Biosynthesis
    Fatty acid, triacylglycerol, and ketone body metabolism
    Gluconeogenesis



    SLC25A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC25A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/277 Interacting proteins for SLC25A1 (P530072, 3 ENSP000002158824) via UniProtKB, MINT, STRING, and/or I2D (see all 277)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1BP203332, 3MINT-49457 I2D: score=2 
    HSPD1P108092, 3MINT-8079030 I2D: score=1 
    MRPL2Q5T6532, 3MINT-8079030 I2D: score=1 
    YME1L1Q96TA22, 3MINT-8079030 I2D: score=1 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006810transport ----
    GO:0006843mitochondrial citrate transport TAS--


    SLC25A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC25A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC25A1

    1 HMDB Compound for SLC25A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Search CenterWatch for drugs/clinical trials and news about SLC25A1 / TXTP 

    Transcripts
    for SLC25A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC25A1 gene (2 alternative transcripts): 
    NM_001256534.1  NM_005984.3  

    Unigene Cluster for SLC25A1:

    Solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
    Hs.111024  [show with all ESTs]
    Unigene Representative Sequence: NM_001256534
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215882(uc021wlb.1 uc002zoz.3) ENST00000451283(uc002zoy.3)
    ENST00000470922 ENST00000461267 ENST00000468824

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC25A1 (see all 25):
    hsa-miR-3673 hsa-miR-10b hsa-miR-331-3p hsa-miR-1271 hsa-miR-339-5p hsa-miR-650 hsa-miR-3190 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: SLC25A1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC25A1 (see all 7)
    OriGene shRNA RFP: SLC25A1
    OriGene siRNA: SLC25A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC25A1
    Clone
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    GenScript: all cDNA clones in your preferred vector: SLC25A1 (NM_012140)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC25A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC25A1

    Additional cDNA sequence: 

    AK292313.1 AK298204.1 BC004980.1 BC008061.2 BC018590.1 HM037273.1 L75823.1 L77567.1 
    NR_033687.2 NR_046298.1 U25147.1 

    22 DOTS entries:

    DT.450055  DT.100031321  DT.95166683  DT.101985047  DT.100884306  DT.100884307  DT.75127184  DT.100884304 
    DT.92444537  DT.100884310  DT.92444536  DT.95166678  DT.95166686  DT.100697812  DT.100772950  DT.102828320 
    DT.92051523  DT.100649618  DT.100884309  DT.92444539  DT.95166694  DT.102828321 

    24/454 AceView cDNA sequences (see all 454):

    CR603634 BX325571 AA383697 BP381826 CR622978 BC018590 BG760237 BM709181 
    BX281981 F12880 CB138751 BU957783 BU957389 R70172 BQ928999 BI871661 
    CR607685 BM687150 CB126735 BU737987 BE293695 R72424 CB250435 BQ957301 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:              -     -     -     -                             -                                             
    SP2:                                                              -                                             
    SP3:                                                              -                                             
    SP4:                                                              -                                             
    SP5:                                                              -                                             


    ECgene alternative splicing isoforms for SLC25A1

    Expression
    for SLC25A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC25A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTGTGTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC25A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC25A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC25A1

    SOURCE GeneReport for Unigene cluster: Hs.111024
        SABiosciences Expression via Pathway-Focused PCR Array including SLC25A1: 
              Mitochondria in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for SLC25A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC25A1 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC25A11 solute carrier family 25 (mitochondrial carrier; citrate more 80.65(n)
    87.42(a)    		   416764  XM_415059.3  XP_415059.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC25A16
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343282.1(823691-836227)
    African clawed frog
    (Xenopus laevis)    		 Amphibia slc25a1-prov2 solute carrier family 25 (mitochondrial carrier; citrate more 75.97(n)    BC041303.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc635782 hypothetical protein MGC63578 73.98(n)   393579  BC056787.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG67823
    fabp1    		 carrier3
    fatty acid bindin protein1    		 66(a)3
    66.78(n)1
    67.58(a)1    		   37722321  NM_001032006.11  NP_001027177.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea K11H3.31 , 3 Mitochondrial carrier family3
    Protein K11H3.31    		 65(a)3
    56.77(n)1
    65.02(a)1    		   III(9923601-9924980)3
    1763981  NM_066786.31  NP_499187.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CTP1(YBR291C)4
    CTP11    		 Mitochondrial inner membrane citrate transporter, member more4
    Ctp1p1    		 46.52(n)1
    40.65(a)1    		   2(784572-783673)4
    8525941, 4  NP_009850.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G013406
    		 Mitochondrial substrate carrier family protein
    		 28(a)
    		 1 ↔ 1
    		 5(143055-144720)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 mitochondrial carrier protein, putative, expressed...
    		 28(a)
    		 1 ↔ 1
    		 3(10170705-10173430)


    ENSEMBL Gene Tree for SLC25A1 (if available)
    TreeFam Gene Tree for SLC25A1 (if available) 

    Paralogs
    for SLC25A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC25A1 gene
    6 SIMAP similar genes for SLC25A1 using alignment to 3 protein entries:     TXTP_HUMAN (see all proteins):
    FLJ00351    SLC25A45    SLC25A21    SLC25A27    SLC25A47    SLC25A17

    SLC25A1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for SLC25A1
    PGOHUM00000242831 PGOHUM00000249101 PGOHUM00000234273 PGOHUM00000233319 PGOHUM00000233347


    Genomic Variants
    for SLC25A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 NCBI SNPs in SLC25A1 are shown (see all 121)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs121706451,2
    		H--19162658(+) GCAGCC/TCATTT 4 -- int14Minor allele frequency- T:0.00NS EA 420
    rs8076681,2
    		C,F,A,H,--19162686(+) GGCATG/ACCCCA 4 -- int19Minor allele frequency- A:0.34NA MN WA CSA EA 555
    rs37470531,2
    		C,A,--19162696(+) AGAGGA/GGCCCT 4 -- int15Minor allele frequency- G:0.27WA CSA EA 243
    rs1162720271,2
    		F,--19162701(+) GGCCCT/CGGGCA 4 -- int11Minor allele frequency- C:0.05WA 118
    rs106773461,2
    		C,--19162752(+) CAGTC-/CTGGTCCT 4 -- int10--------
    rs1147535901,2
    		F,--19162774(+) CTCCTG/AGGCCC 4 -- int11Minor allele frequency- A:0.02WA 118
    rs37470541,2
    		C,F,H,--19162883(+) GCCAGG/CGTGCA 4 -- int17Minor allele frequency- C:0.38NS EA WA 656
    rs1395598031,2
    		--19163011(+) TGGGGA/GTGGCC 4 -- int10--------
    rs57466731,2
    		--19163047(+) CAATGC/TCCATG 4 -- int10--------
    rs733927961,2
    		C,--19163249(+) AGGCCG/AAGGCC 4 -- nc-transcript-variantut312Minor allele frequency- A:0.04WA 120

    HapMap Linkage Disequilibrium report for SLC25A1 (19163094 - 19166343 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC25A1
         1 CNV: 31071

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    Disorders / Diseases
    for SLC25A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC25A1 for disorders           About GeneDecksing

    OMIM gene information: 190315    OMIM disorders: --

    4 diseases for SLC25A1:    About MalaCards
    velocardiofacial syndrome    digeorge syndrome    hepatitis    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for SLC25A1:
    Velocardiofacial syndrome     DiGeorge syndrome
    Human Genome Epidemiology (HuGE) Navigator: SLC25A1 (2 documents)

    Export disorders for SLC25A1 gene to outside databases

    Publications
    for SLC25A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC25A1 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with SLC25A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the human mitochondrial citrate transporter protein gene to chromosome 22q11 in the DiGeorge syndrome critical region. (PubMed id 8666394)1, 2, 3 Heisterkamp N.... Groffen J. (1995)
    2. Cloning, genomic organization, and chromosomal localization of human citrate transport protein to the DiGeorge/velocardiofacial syndrome minimal critical region. (PubMed id 8660975)1, 2, 9 Goldmuntz E.... Budarf M.L. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Organization and sequence of the human gene for the mitochondrial citrate transport protein. (PubMed id 9254007)1, 3 Iacobazzi V....Palmieri F. (1997)
    5. The mitochondrial tricarboxylate transport protein. c DNA cloning, primary structure, and comparison with other mitochondrial transpo rt proteins. (PubMed id 8514800)1, 9 Kaplan R.S....Wood D.O. (1993)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (2012)
    8. The mitochondrial citrate carrier (CIC) is present and regulates insulin secretion by human male gamete. (PubMed id 22355067)1 Cappello A.R....Aquila S. (2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    10. Treatment by oral creatine, L-arginine and L-glycine i n six severely affected patients with creatine transporter defect. (PubMed id 21660517)1 Valayannopoulos V....de Lonlay P. (2012)

    External Searches for SLC25A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing SLC25A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6576 HGNC: 10979 AceView: SLC25A1 Ensembl:ENSG00000100075 euGenes: HUgn6576
    ECgene: SLC25A1 H-InvDB: SLC25A1

    Other Databases showing SLC25A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC25A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC25A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC25A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC25A1 gene:
    Search GeneIP for patents involving SLC25A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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