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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC24A6 Gene

protein-coding   GIFtS: 50
GCID: GC12M113736

solute carrier family 24 (sodium/lithium/calcium exchanger),...

(Previous names: solute carrier family 24 (sodium/potassium/calcium exchanger),...)
 Explore 1 disease affiliated with
SLC24A6 via our new
 Human Malady Compendium 
Biological research products
for SLC24A6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 24 (Sodium/Lithium/Calcium Exchanger), Member 61 2     Solute Carrier Family 24 Member 62 3
NCKX61 2 3 5     Na(+)/K(+)/Ca(2+)-Exchange Protein 62 3
NCLX1 2 3     FLJ222331
Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 61 2     Sodium/Potassium/Calcium Exchanger 6, Mitochondrial2
Sodium/Calcium Exchanger Protein, Mitochondrial2 3     

External Ids:    HGNC: 261751   Entrez Gene: 800242   Ensembl: ENSG000000890607   OMIM: 6098415   UniProtKB: Q6J4K23   

Export aliases for SLC24A6 gene to outside databases

Previous GC identifers: GC12M112149 GC12M112199 GC12M110749


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC24A6:
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis
through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004
(PubMed 14625281)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: NCKX6_HUMAN, Q6J4K2
Function: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion,
thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin
secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium
from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either
Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its
function is independent of K(+)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC24A6 gene promoter:
         Bach1   NF-YA   HSF1 (long)   CBF-C   NF-YB   CBF-B   HSF1short   CP1A   CP1C   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC24A6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC24A6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC24A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.13

SLC24A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC24A6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M113736:  view genomic region     (about GC identifiers)

Start:
113,736,564 bp from pter      End:
113,797,298 bp from pter
Size:
60,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NCKX6_HUMAN, Q6J4K2 (See protein sequence)
Recommended Name: Sodium/potassium/calcium exchanger 6, mitochondrial precursor  
Size: 584 amino acids; 64231 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane
protein (By similarity). Note=Mainly localizes to mitochondrion inner membrane
Sequence caution: Sequence=BAB15271.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NP50 Q4KMS9 Q6J4K1 Q9H6I8
Alternative splicing: 2 isoforms:  Q6J4K2-1   Q6J4K2-2   

Explore the universe of human proteins at neXtProt for SLC24A6: NX_Q6J4K2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6J4K2

  • SLC24A6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079235.2  
    ENSEMBL proteins: 
     ENSP00000447091   ENSP00000448758   ENSP00000447585   ENSP00000449519   ENSP00000450081  
     ENSP00000448703   ENSP00000448749   ENSP00000447502   ENSP00000449448   ENSP00000447972  
     ENSP00000202831  
    Reactome Protein details: Q6J4K2
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC24A6

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane ----
    GO:0032592integral to mitochondrial membrane IDA--
    GO:0042383sarcolemma IEA--


    SLC24A6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC24A6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004837 NaCa_Exmemb

    Graphical View of Domain Structure for InterPro Entry Q6J4K2

    ProtoNet protein and cluster: Q6J4K2

    1 Blocks protein family: IPB004837 Sodium/calcium exchanger membrane region

    UniProtKB/Swiss-Prot: NCKX6_HUMAN, Q6J4K2
    Similarity: Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NCKX6_HUMAN, Q6J4K2
    Function: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion,
    thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin
    secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium
    from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either
    Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its
    function is independent of K(+)
    Enzyme regulation: Strongly inhibited by zinc

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005432calcium:sodium antiporter activity IDA--
    GO:0015297antiporter activity ----


    SLC24A6 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport1.00
    Transmembrane transport of small molecules0.50
    2Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    3Sodium-coupled transporters and pumps
    Sodium/Calcium exchangers0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC24A6
        Sodium/Calcium exchangers
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides



    SLC24A6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC24A6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/7 Interacting proteins for SLC24A6 (Q6J4K23 ENSP000002028314) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALG1Q9BT223I2D: score=1 
    DHX8Q145623I2D: score=1 
    HSD17B12Q53GQ03I2D: score=1 
    HSP90AA1P079003I2D: score=1 
    SUPT16HQ9Y5B93I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport ----
    GO:0006816calcium ion transport ----
    GO:0006851mitochondrial calcium ion transport IMP--
    GO:0042593glucose homeostasis IDA--


    SLC24A6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC24A6 for compounds           About GeneDecksing

    EMD Millipore small molecules for SLC24A6:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC24A6

    3 HMDB Compounds for SLC24A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    LithiumLi (see all 5)7439-93-2--
    SodiumSodium (see all 2)7440-23-5--
    2 Novoseek chemical compound relationships for SLC24A6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 27 2 10662833 (1), 12502573 (1)
    calcium 25.3 2 17716241 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC24A6 / NCKX6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC24A6 gene: 
    NM_024959.2  

    Unigene Cluster for SLC24A6:

    Solute carrier family 24 (sodium/lithium/calcium exchanger), member 6
    Hs.286194  [show with all ESTs]
    Unigene Representative Sequence: NM_024959
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552014(uc001tvb.3) ENST00000552565(uc001tuz.3) ENST00000550672(uc001tva.3)
    ENST00000550047 ENST00000549069 ENST00000546737 ENST00000553238 ENST00000551230
    ENST00000548477(uc001tvd.1) ENST00000549181 ENST00000549605 ENST00000552613
    ENST00000548186 ENST00000549372 ENST00000548518 ENST00000202831(uc001tvc.3)


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    Additional cDNA sequence: 

    AK025886.1 AK293216.1 AY601759.1 AY601760.1 BC020463.1 BC032397.1 BC033070.1 BC098174.1 
    BC098360.1 BC098430.1 CR749870.1 

    12 DOTS entries:

    DT.100781621  DT.97843132  DT.100025518  DT.100694105  DT.121178265  DT.100808236  DT.91700950  DT.102826742 
    DT.100025516  DT.75165491  DT.100025519  DT.101977390 

    24/197 AceView cDNA sequences (see all 197):

    AI363389 AI923622 BP344661 NM_024959 BI753221 AY601760 BX509340 BQ082488 
    CR749870 BM980568 BC033070 AW615186 BE741004 AI828651 BQ947796 BQ878274 
    AW001889 AI923644 T34433 AI685377 M62040 AK094074 BC032397 BQ936418 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SLC24A6 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                                                                          -     -                                         -           -                 -   
    SP2:                                                                    -     -     -                                         -           -                 -   
    SP3:                                                                          -     -                                         -           -                     
    SP4:                                                                                                  -                       -           -                 -   
    SP5:                    -                 -                                                                                                                     

    ExUns: 18a · 18b · 18c · 18d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SLC24A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC24A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SLC24A6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC24A6

    SOURCE GeneReport for Unigene cluster: Hs.286194

    UniProtKB/Swiss-Prot: NCKX6_HUMAN, Q6J4K2
    Tissue specificity: Present in pancreatic beta-cells (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC24A6 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC24A61 solute carrier family 24 (sodium/potassium/calcium more 69.99(n)
    68.13(a)
      417032  XM_415321.2  XP_415321.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC24A66
    --
    68(a)
    1 ↔ 1
    GL343338.1(847464-861025)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.161302 Transcribed sequence with weak similarity to protein more 75.66(n)    AL888077.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5606011 sodium/potassium/calcium exchanger 6-like 61.54(n)
    59.89(a)
      560601  XM_683999.5  XP_689091.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG147441 CG14744 45.67(n)
    31.59(a)
      35858  NM_001103762.2  NP_001097232.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ncx-71 Protein NCX-7 43.81(n)
    37.77(a)
      176370  NM_066746.5  NP_499147.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G178501 Sodium/calcium exchanger family protein 44.09(n)
    36.5(a)
      831653  NM_121791.1  NP_197287.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06565001 hypothetical protein 49.15(n)
    35.26(a)
      4333615  NM_001057344.1  NP_001050809.1 


    ENSEMBL Gene Tree for SLC24A6 (if available)
    TreeFam Gene Tree for SLC24A6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC24A6 gene
    SLC24A52  SLC24A42  SLC8A22  SLC24A22  SLC8A32  SLC24A32  SLC8A12  SLC24A12  

    SLC24A6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/665 NCBI SNPs in SLC24A6 are shown (see all 665    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784685501,2
    C,--113736985(+) GCCACG/AANNNN 1 -- ut313Minor allele frequency- A:0.25WA NA 240
    rs752736201,2
    --113737005(+) CTTTTG/AGCTTT 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1899705351,2
    --113737076(+) GGTGCA/GGCTCT 1 -- ut310--------
    rs1826316441,2
    --113737083(+) CTCTGG/TAGCTC 1 -- ut310--------
    rs1863280841,2
    --113737099(+) TCGGCA/GGCCTG 1 -- ut310--------
    rs169342531,2
    C,F,H,--113737225(+) GCCTCG/AGGGGT 1 -- ut31 ese318Minor allele frequency- A:0.20NA NS EA WA CSA 1673
    rs731928451,2
    C,--113737267(+) ATCCCC/TTTCCC 1 -- ut310--------
    rs1481487451,2
    --113737270(+) CCCTTC/TCCCCA 1 -- ut310--------
    rs1440943951,2
    --113737303(+) GCTCTA/GGGGGT 1 -- ut310--------
    rs1473371591,2
    --113737382(+) CCCACA/GGCAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC24A6 (113736564 - 113797298 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC24A6: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC24A6 for disorders           About GeneDecksing

    OMIM gene information: 609841    OMIM disorders: --

    1 disease for SLC24A6:    About MalaCards
    retinitis


    Export disorders for SLC24A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC24A6 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SLC24A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lithium-calcium exchange is mediated by a distinct potassium- independent sodium-calcium exchanger. (PubMed id 15060069)1, 2, 9 Palty R.... Sekler I. (2004)
    2. Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6. (PubMed id 14625281)1, 3 Cai X. and Lytton J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The mitochondrial na(+)/ca(2+) exchanger upregulates glucose dependent ca(2+) signalling linked to insulin secretion. (PubMed id 23056385)2 Nita I.I.... Sekler I. (2012)
    6. The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic beta-cells. (PubMed id 22829870)2 Tarasov A.I.... Rutter G.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. NCLX is an essential component of mitochondrial Na+/C a2+ exchange. (PubMed id 20018762)2 Palty R....Sekler I. (2010)
    10. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80024 HGNC: 26175 AceView: SLC24A6 Ensembl:ENSG00000089060 euGenes: HUgn80024
    ECgene: SLC24A6 H-InvDB: SLC24A6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC24A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC24A6 gene:
    Search GeneIP for patents involving SLC24A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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