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SLC24A3 Gene

protein-coding   GIFtS: 55
GCID: GC20P019141

Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger),...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member
31 2
NCKX32 3 5
Solute Carrier Family 24 Member 32 3
Na(+)/K(+)/Ca(2+)-Exchange Protein 32 3
Sodium Calcium Exchanger2
Sodium/Potassium/Calcium Exchanger 32

External Ids:    HGNC: 109771   Entrez Gene: 574192   Ensembl: ENSG000001850527   OMIM: 6098395   UniProtKB: Q9HC583   

Export aliases for SLC24A3 gene to outside databases

Previous GC identifers: GC20P019181 GC20P019188


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC24A3 Gene:
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and
electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1
intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 (PubMed
11294880)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC24A3 Gene:
SLC24A3 (solute carrier family 24 (sodium/potassium/calcium exchanger), member 3) is a protein-coding gene. Diseases associated with SLC24A3 include tako-tsubo cardiomyopathy, and brain ischemia. GO annotations related to this gene include calcium, potassium:sodium antiporter activity and symporter activity. An important paralog of this gene is SLC24A5.

UniProtKB/Swiss-Prot: NCKX3_HUMAN, Q9HC58
Function: Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC24A3 gene promoter:
         SRF   p53   Nkx2-2   SRF (504 AA)   AP-4   LCR-F1   AREB6   FOXJ2 (long isoform)   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC24A3 promoter sequence
   Search Chromatin IP Primers for SLC24A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC24A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p13

SLC24A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC24A3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P019141:  view genomic region     (about GC identifiers)

Start:
19,193,290 bp from pter      End:
19,703,581 bp from pter
Size:
510,292 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NCKX3_HUMAN, Q9HC58 (See protein sequence)
Recommended Name: Sodium/potassium/calcium exchanger 3 precursor  
Size: 644 amino acids; 71992 Da
Secondary accessions: B1AKV7 Q9BQJ9 Q9BQL7 Q9BQY3 Q9H519

Explore the universe of human proteins at neXtProt for SLC24A3: NX_Q9HC58

Explore proteomics data for SLC24A3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn86
  • Modification sites at PhosphoSitePlus

  • See SLC24A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065740.2  
    ENSEMBL proteins: 
     ENSP00000333519  
    Reactome Protein details: Q9HC58

    SLC24A3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/potassium/calcium exchanger 3
    SLC24 family of sodium/potassium/calcium exchangers

    2 InterPro protein domains:
     IPR004481 K/Na/Ca-exchanger
     IPR004837 NaCa_Exmemb

    Graphical View of Domain Structure for InterPro Entry Q9HC58

    ProtoNet protein and cluster: Q9HC58

    1 Blocks protein domain: IPB004837 Sodium/calcium exchanger membrane region

    UniProtKB/Swiss-Prot: NCKX3_HUMAN, Q9HC58
    Similarity: Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily


    SLC24A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCKX3_HUMAN, Q9HC58
    Function: Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008273calcium, potassium:sodium antiporter activity IEA--
    GO:0015293symporter activity IEA--
         
    SLC24A3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC24A3:
     Increased circadian period len  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC24A3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC24A3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC24A3

    miRNA
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    Block miRNA regulation of human, mouse, rat SLC24A3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC24A3 (see all 39):
    hsa-miR-548j hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-301a hsa-miR-424 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC24A3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC24A3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC24A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCKX3_HUMAN, Q9HC58: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    SLC24A3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC24A3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Sodium/Calcium exchangers0.00
    2Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC24A3
        Visual Cycle in Retinal Rods

    1 Reactome Pathway for SLC24A3
        Sodium/Calcium exchangers



    SLC24A3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC24A3
    Interactions:

        Search GeneGlobe Interaction Network for SLC24A3

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0055085transmembrane transport TAS--

    SLC24A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC24A3 (NCKX3)

    2 HMDB Compounds for SLC24A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--

    Selected Novoseek inferred chemical compound relationships for SLC24A3 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    p-mca 80.9 4 17446465 (1), 17668452 (1), 16796818 (1), 17051729 (1)
    3',4'-dichlorobenzamil 78.1 2 15010500 (1)
    sea 0400 72.2 1 11877314 (1)
    calcium 65.1 71 10652193 (3), 9520864 (2), 17419759 (2), 8382966 (2) (see all 42)
    n-methyl-d-glucamine 60.1 1 15060069 (1)
    sodium 59.5 18 8410703 (2), 9212080 (1), 17805013 (1), 18523740 (1) (see all 11)
    ryanodine 47.3 5 16317512 (1), 19525500 (1), 9520864 (1), 19460074 (1) (see all 5)
    ouabain 44.7 3 15554913 (2), 8382966 (1)
    mgatp 33.6 1 11897850 (1)
    amiloride 32.8 3 11600230 (2), 15010500 (1)



    SLC24A3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC24A3 gene: 
    NM_020689.3  

    Unigene Cluster for SLC24A3:

    Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
    Hs.654790  [show with all ESTs]
    Unigene Representative Sequence: NM_020689
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328041(uc002wrl.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC24A3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC24A3 (see all 39):
    hsa-miR-548j hsa-miR-15a hsa-miR-503 hsa-miR-25 hsa-miR-301a hsa-miR-424 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC24A3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC24A3
      QuantiFast Probe-based Assays in human, mouse, rat SLC24A3

    Additional mRNA sequence: 

    AF169257.2 AF288087.1 

    2 DOTS entries:

    DT.312468  DT.97764313 

    Selected AceView cDNA sequences (see all 68):

    CD514688 BM090639 CA389783 BM090857 AI655223 BU580564 BG055727 AI753456 
    AW302348 BE671771 BM711865 AL603345 BE672267 BE714200 AI224564 BU727587 
    F12855 F10455 BE714350 AI091786 AA195627 AA827422 BE714260 T03762 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC24A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTTCACT
    SLC24A3 Expression
    About this image


    SLC24A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Uterus (Reproductive System)
    SLC24A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC24A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654790

    UniProtKB/Swiss-Prot: NCKX3_HUMAN, Q9HC58
    Tissue specificity: Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC24A3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc24a31 , 5 solute carrier family 24 (sodium/potassium/calcium more1, 5 89.47(n)1
    96.45(a)1
      2 (71.08 cM)5
    942491  NM_053195.21  NP_444425.11 
     1451677545 
    chicken
    (Gallus gallus)
    Aves SLC24A31 solute carrier family 24 (sodium/potassium/calcium more 79.34(n)
    88.79(a)
      421244  XM_004940145.1  XP_004940202.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC24A36
    solute carrier family 24 (sodium/potassium/calcium...
    79(a)
    1 ↔ 1
    4(80134886-80392654)
    zebrafish
    (Danio rerio)
    Actinopterygii slc24a31 solute carrier family 24 (sodium/potassium/calcium more 68.72(n)
    70.87(a)
      557196  XM_680210.5  XP_685302.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG28931 , 3 calcium, potassium:sodium antiporter3
    CG28931
    46(a)
    (best of 3)3
    52.8(n)1
    46(a)1
      33549921  NM_001015260.21  NP_001015260.31 


    ENSEMBL Gene Tree for SLC24A3 (if available)
    TreeFam Gene Tree for SLC24A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC24A3 gene
    SLC24A52  SLC8B12  SLC24A42  SLC24A12  SLC24A22  
    4 SIMAP similar genes for SLC24A3 using alignment to 1 protein entry:     NCKX3_HUMAN:
    SLC24A4    SLC24A2    SLC24A1    SLC24A5

    SLC24A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC24A3 (see all 10407)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58408351,2
    C--19173721(+) GGGGG-/AG    
       
    /G/GG
    TGCCC
    1 -- int11CSA 2
    rs61060301,2
    C,F,A--19191319(+) GAGCTA/TGTGTT 1 -- us2k111Minor allele frequency- T:0.40NA WA CSA EA 372
    rs1914331991,2
    --19191379(+) CCCTCG/TTTTTC 1 -- us2k10--------
    rs60459081,2
    C,F,A--19191404(+) TTTGAA/GTGACT 1 -- us2k112Minor allele frequency- G:0.33NA WA CSA EA 374
    rs1152351941,2
    C,F--19191564(+) AAAGCA/GAAGGG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1817582671,2
    --19191582(+) CTCAGC/GCATTG 1 -- us2k10--------
    rs41419811,2
    C,F--19191679(+) CTCCCG/TGGGTG 1 -- us2k15Minor allele frequency- T:0.39NA CSA EA 127
    rs114783641,2
    C--19191790(+) AGGTC-/GGGGGG 1 -- us2k12Minor allele frequency- G:0.00NA CSA 4
    rs1873222141,2
    C--19191996(+) CAGCGA/CCCCCC 1 -- us2k10--------
    rs1131992031,2
    C,F--19192005(+) CCCACC/TCTCCG 1 -- us2k13Minor allele frequency- T:0.04CSA WA EA 240

    HapMap Linkage Disequilibrium report for SLC24A3 (19193290 - 19443290 bp, first 250kb of SLC24A3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC24A3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722274CNV Deletion23290073
    esv2670085CNV Deletion23128226
    nsv3316CNV Insertion18451855
    esv2652551CNV Insertion19546169
    esv267761CNV Insertion20981092
    esv273939CNV Insertion20981092
    nsv3317CNV Insertion18451855
    nsv3315CNV Loss18451855
    nsv527125CNV Loss19592680
    nsv833938CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609839    OMIM disorders: --

    14 diseases for SLC24A3:    
    About MalaCards
    tako-tsubo cardiomyopathy    brain ischemia    ischemia    congestive heart failure
    pulmonary function    malignant glioma    multiple sclerosis    asthma
    cerebritis    retinitis    neuroblastoma    endotheliitis
    malaria    neuronitis


    SLC24A3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for SLC24A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arrhythmia 38.6 5 15653340 (1), 9653715 (1), 12555155 (1), 16079546 (1)
    heart failure 38.1 5 15653340 (1), 7864717 (1), 19661061 (1), 16079546 (1)
    myocardial ischemia 13.6 1 15653340 (1)
    ischemia 5.54 3 11257426 (2), 18373324 (1)

    Genetic Association Database (GAD): SLC24A3
    Human Genome Epidemiology (HuGE) Navigator: SLC24A3 (2 documents)

    Export disorders for SLC24A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC24A3 gene, integrated from 10 sources (see all 108):
    (articles sorted by number of sources associating them with SLC24A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3. (PubMed id 11294880)1, 2, 9 Kraev A.... Lytton J. (J. Biol. Chem. 2001)
    2. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels. (PubMed id 20031604)1, 4 Cheng Y.C....Pollin T.I. (Circ Cardiovasc Genet 2009)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Distinct expression of the calcium exchangers, NCKX3 and NCX1, and their regulation by steroid in the human endometrium during the menstrual cycle. (PubMed id 21321244)1 Yang H....Jeung E.B. (Reprod Sci 2011)
    7. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    8. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. (PubMed id 18463370)4 Maris J.M....Hakonarson H. (N. Engl. J. Med. 2008)
    9. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57419 HGNC: 10977 AceView: SLC24A3 Ensembl:ENSG00000185052 euGenes: HUgn57419
    ECgene: SLC24A3 H-InvDB: SLC24A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC24A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC24A3 gene:
    Search GeneIP for patents involving SLC24A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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