Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC24A3 Gene

Aliases for SLC24A3 Gene

  • Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 3 2 3
  • Na(+)/K(+)/Ca(2+)-Exchange Protein 3 3 4
  • Solute Carrier Family 24 Member 3 3 4
  • NCKX3 3 4
  • Sodium Calcium Exchanger 3

External Ids for SLC24A3 Gene

Previous GeneCards Identifiers for SLC24A3 Gene

  • GC20P019181
  • GC20P019188

Summaries for SLC24A3 Gene

Entrez Gene Summary for SLC24A3 Gene

  • Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC24A3 Gene

SLC24A3 (Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Visual Cycle in Retinal Rods. GO annotations related to this gene include symporter activity and calcium, potassium:sodium antiporter activity. An important paralog of this gene is SLC24A4.

UniProtKB/Swiss-Prot for SLC24A3 Gene

  • Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC24A3 Gene

Genomics for SLC24A3 Gene

Regulatory Elements for SLC24A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC24A3 Gene

Chromosome:
20
Start:
19,212,646 bp from pter
End:
19,722,937 bp from pter
Size:
510,292 bases
Orientation:
Plus strand

Genomic View for SLC24A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC24A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC24A3 Gene

Proteins for SLC24A3 Gene

  • Protein details for SLC24A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC58-NCKX3_HUMAN
    Recommended name:
    Sodium/potassium/calcium exchanger 3
    Protein Accession:
    Q9HC58
    Secondary Accessions:
    • B1AKV7
    • Q9BQJ9
    • Q9BQL7
    • Q9BQY3
    • Q9H519

    Protein attributes for SLC24A3 Gene

    Size:
    644 amino acids
    Molecular mass:
    71992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC24A3 Gene

Proteomics data for SLC24A3 Gene at MOPED

Post-translational modifications for SLC24A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC24A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC24A3

No data available for DME Specific Peptides for SLC24A3 Gene

Domains & Families for SLC24A3 Gene

Gene Families for SLC24A3 Gene

Protein Domains for SLC24A3 Gene

Suggested Antigen Peptide Sequences for SLC24A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HC58

UniProtKB/Swiss-Prot:

NCKX3_HUMAN :
  • Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.
Family:
  • Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.
genes like me logo Genes that share domains with SLC24A3: view

Function for SLC24A3 Gene

Molecular function for SLC24A3 Gene

UniProtKB/Swiss-Prot Function:
Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Gene Ontology (GO) - Molecular Function for SLC24A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 calcium channel activity IBA --
GO:0005509 calcium ion binding IBA --
GO:0008273 calcium, potassium:sodium antiporter activity IBA --
GO:0015293 symporter activity IEA --
GO:0030955 potassium ion binding IBA --
genes like me logo Genes that share ontologies with SLC24A3: view
genes like me logo Genes that share phenotypes with SLC24A3: view

Animal Model Products

CRISPR Products

miRNA for SLC24A3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC24A3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC24A3 Gene

Localization for SLC24A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC24A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC24A3 Gene COMPARTMENTS Subcellular localization image for SLC24A3 gene
Compartment Confidence
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC24A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC24A3: view

Pathways & Interactions for SLC24A3 Gene

genes like me logo Genes that share pathways with SLC24A3: view

Interacting Proteins for SLC24A3 Gene

Gene Ontology (GO) - Biological Process for SLC24A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006813 potassium ion transport IEA --
GO:0006816 calcium ion transport --
GO:0006874 cellular calcium ion homeostasis IBA --
GO:0035725 sodium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC24A3: view

No data available for SIGNOR curated interactions for SLC24A3 Gene

Drugs & Compounds for SLC24A3 Gene

(9) Drugs for SLC24A3 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amiloride Approved Pharma Channel blocker 45
Isoproterenol Approved Pharma Full agonist, Agonist 15
Lithium Approved Pharma 206
Ouabain Approved Pharma Na+/K+ ATPase inhibitor 0
Caffeine Approved Nutra Activator 317

(8) Additional Compounds for SLC24A3 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
3,4-Dichlorobenzamil
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
MgAtp
n-methyl-d-glucamine
genes like me logo Genes that share compounds with SLC24A3: view

Transcripts for SLC24A3 Gene

mRNA/cDNA for SLC24A3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC24A3 Gene

Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC24A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC24A3 Gene

No ASD Table

Relevant External Links for SLC24A3 Gene

GeneLoc Exon Structure for
SLC24A3
ECgene alternative splicing isoforms for
SLC24A3

Expression for SLC24A3 Gene

mRNA expression in normal human tissues for SLC24A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC24A3 Gene

This gene is overexpressed in Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for SLC24A3 Gene

This gene is overexpressed in Heart (52.9) and Peripheral blood mononuclear cells (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC24A3 Gene



SOURCE GeneReport for Unigene cluster for SLC24A3 Gene Hs.654790

mRNA Expression by UniProt/SwissProt for SLC24A3 Gene

Q9HC58-NCKX3_HUMAN
Tissue specificity: Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine
genes like me logo Genes that share expression patterns with SLC24A3: view

Protein tissue co-expression partners for SLC24A3 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC24A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC24A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC24A3 35
  • 88.8 (n)
  • 92.68 (a)
SLC24A3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC24A3 35
  • 90.44 (n)
  • 96.29 (a)
SLC24A3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc24a3 35
  • 89.47 (n)
  • 96.45 (a)
Slc24a3 16
Slc24a3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC24A3 35
  • 98.71 (n)
  • 98.71 (a)
SLC24A3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc24a3 35
  • 89.25 (n)
  • 95.33 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC24A3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC24A3 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC24A3 35
  • 79.34 (n)
  • 88.79 (a)
SLC24A3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC24A3 36
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc24a3 35
  • 68.72 (n)
  • 70.87 (a)
slc24a3 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1090 37
  • 35 (a)
CG12061 37
  • 37 (a)
CG2893 37
  • 46 (a)
CG2893 35
  • 52.8 (n)
  • 46 (a)
CG12061 36
  • 37 (a)
ManyToMany
CG17167 36
  • 29 (a)
ManyToMany
CG2893 36
  • 38 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010975 35
  • 53.09 (n)
  • 47.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1993 36
  • 32 (a)
OneToMany
Species with no ortholog for SLC24A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC24A3 Gene

ENSEMBL:
Gene Tree for SLC24A3 (if available)
TreeFam:
Gene Tree for SLC24A3 (if available)

Paralogs for SLC24A3 Gene

Paralogs for SLC24A3 Gene

(4) SIMAP similar genes for SLC24A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC24A3: view

Variants for SLC24A3 Gene

Sequence variations from dbSNP and Humsavar for SLC24A3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8994 -- 19,722,691(+) AACCT(A/G)CTACA utr-variant-3-prime
rs591340 -- 19,522,569(-) AAGAT(A/C)AAAAA intron-variant
rs592780 -- 19,522,234(-) TCAAG(C/T)TGATG intron-variant
rs598361 -- 19,518,331(-) AGTGA(A/G)GCCAT intron-variant
rs606246 -- 19,524,580(-) CTCCA(A/C/T)ATGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC24A3 Gene

Variant ID Type Subtype PubMed ID
esv2722274 CNV Deletion 23290073
esv2670085 CNV Deletion 23128226
nsv833937 CNV Gain 17160897
nsv912811 CNV Loss 21882294
nsv3315 CNV Loss 18451855
esv273939 CNV Insertion 20981092
esv267761 CNV Insertion 20981092
nsv527125 CNV Loss 19592680
nsv833938 CNV Loss 17160897
nsv3316 CNV Insertion 18451855
esv2652551 CNV Insertion 19546169
nsv3317 CNV Insertion 18451855

Variation tolerance for SLC24A3 Gene

Residual Variation Intolerance Score: 74.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.90; 94.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC24A3 Gene

HapMap Linkage Disequilibrium report
SLC24A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC24A3 Gene

Disorders for SLC24A3 Gene

Relevant External Links for SLC24A3

Genetic Association Database (GAD)
SLC24A3
Human Genome Epidemiology (HuGE) Navigator
SLC24A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC24A3
genes like me logo Genes that share disorders with SLC24A3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC24A3 Gene

Publications for SLC24A3 Gene

  1. The initiation of the heart beat. (PMID: 20019407) Chen P.S. … Lin S.F. (Circ. J. 2010) 23 67
  2. Binding of calcium is sensed structurally and dynamically throughout the second calcium-binding domain of the sodium/calcium exchanger. (PMID: 20187120) Breukels V. … Vuister G.W. (Proteins 2010) 23 67
  3. Plasma membrane calcium pump and sodium-calcium exchanger in maintenance and control of calcium concentrations in platelets. (PMID: 20045675) Juska A. (Biochem. Biophys. Res. Commun. 2010) 23 67
  4. Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner. (PMID: 19481548) Soliman D. … Light P.E. (J. Mol. Cell. Cardiol. 2009) 23 67
  5. Deficiency of testosterone associates with the substrate of atrial fibrillation in the rat model. (PMID: 19460074) Tsuneda T. … Inoue H. (J. Cardiovasc. Electrophysiol. 2009) 23 67

Products for SLC24A3 Gene

Sources for SLC24A3 Gene

Back to Top

Content