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Aliases for SLC24A2 Gene

Aliases for SLC24A2 Gene

  • Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 2 2 3
  • NCKX2 3 4 6
  • Na(+)/K(+)/Ca(2+)-Exchange Protein 2 3 4
  • Retinal Cone Na-Ca+K Exchanger 3 4
  • Sodium/Potassium/Calcium Exchanger 2 3
  • Solute Carrier Family 24 Member 2 4

External Ids for SLC24A2 Gene

Previous GeneCards Identifiers for SLC24A2 Gene

  • GC09M019846
  • GC09M019704
  • GC09M019505
  • GC09M019468

Summaries for SLC24A2 Gene

Entrez Gene Summary for SLC24A2 Gene

  • This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for SLC24A2 Gene

SLC24A2 (Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 2) is a Protein Coding gene. Diseases associated with SLC24A2 include brain injury. Among its related pathways are Visual Cycle in Retinal Rods and The phototransduction cascade. GO annotations related to this gene include protein dimerization activity and symporter activity. An important paralog of this gene is SLC24A4.

UniProtKB/Swiss-Prot for SLC24A2 Gene

  • Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC24A2 Gene

Genomics for SLC24A2 Gene

Regulatory Elements for SLC24A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC24A2 Gene

Start:
19,507,452 bp from pter
End:
19,789,059 bp from pter
Size:
281,608 bases
Orientation:
Minus strand

Genomic View for SLC24A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC24A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC24A2 Gene

Proteins for SLC24A2 Gene

  • Protein details for SLC24A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI40-NCKX2_HUMAN
    Recommended name:
    Sodium/potassium/calcium exchanger 2
    Protein Accession:
    Q9UI40
    Secondary Accessions:
    • B7ZLL8
    • Q9NTN5
    • Q9NZQ4

    Protein attributes for SLC24A2 Gene

    Size:
    661 amino acids
    Molecular mass:
    73664 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC24A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC24A2 Gene

Proteomics data for SLC24A2 Gene at MOPED

Post-translational modifications for SLC24A2 Gene

  • Glycosylation at Asn111
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC24A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC24A2 Gene

Domains for SLC24A2 Gene

Gene Families for SLC24A2 Gene

Protein Domains for SLC24A2 Gene

Suggested Antigen Peptide Sequences for SLC24A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI40

UniProtKB/Swiss-Prot:

NCKX2_HUMAN :
  • Q9UI40
Family:
  • Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.
genes like me logo Genes that share domains with SLC24A2: view

Function for SLC24A2 Gene

Molecular function for SLC24A2 Gene

UniProtKB/Swiss-Prot Function: Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)

Gene Ontology (GO) - Molecular Function for SLC24A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 calcium channel activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008273 calcium, potassium:sodium antiporter activity IDA 18166528
GO:0015293 symporter activity IEA --
GO:0016151 nickel cation binding IEA --
genes like me logo Genes that share ontologies with SLC24A2: view
genes like me logo Genes that share phenotypes with SLC24A2: view

Animal Models for SLC24A2 Gene

MGI Knock Outs for SLC24A2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC24A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC24A2 Gene

Localization for SLC24A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC24A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC24A2 Gene COMPARTMENTS Subcellular localization image for SLC24A2 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC24A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC24A2: view

Pathways for SLC24A2 Gene

genes like me logo Genes that share pathways with SLC24A2: view

Interacting Proteins for SLC24A2 Gene

Gene Ontology (GO) - Biological Process for SLC24A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006813 potassium ion transport IEA --
GO:0006816 calcium ion transport --
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0007601 visual perception IEA --
genes like me logo Genes that share ontologies with SLC24A2: view

Compounds for SLC24A2 Gene

(2) HMDB Compounds for SLC24A2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Sodium
  • Sodium
7440-23-5

(2) Novoseek inferred chemical compound relationships for SLC24A2 Gene

Compound -log(P) Hits PubMed IDs
calcium 22.7 1
cysteine 14.5 3
genes like me logo Genes that share compounds with SLC24A2: view

Transcripts for SLC24A2 Gene

mRNA/cDNA for SLC24A2 Gene

(5) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC24A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC24A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -

Relevant External Links for SLC24A2 Gene

GeneLoc Exon Structure for
SLC24A2
ECgene alternative splicing isoforms for
SLC24A2

Expression for SLC24A2 Gene

mRNA expression in normal human tissues for SLC24A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC24A2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.4), Brain - Putamen (basal ganglia) (6.0), Brain - Caudate (basal ganglia) (5.7), Brain - Spinal cord (cervical c-1) (5.0), Brain - Cortex (4.8), Brain - Anterior cingulate cortex (BA24) (4.5), Brain - Hippocampus (4.4), and Brain - Substantia nigra (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC24A2 Gene

SOURCE GeneReport for Unigene cluster for SLC24A2 Gene Hs.283014

genes like me logo Genes that share expressions with SLC24A2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC24A2 Gene

Orthologs for SLC24A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC24A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC24A2 35
  • 99.6 (n)
  • 99.7 (a)
SLC24A2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC24A2 35
  • 90.57 (n)
  • 92.59 (a)
SLC24A2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC24A2 35
  • 92.69 (n)
  • 93.49 (a)
SLC24A2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc24a2 35
  • 87.85 (n)
  • 90.17 (a)
Slc24a2 16
Slc24a2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC24A2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC24A2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc24a2 35
  • 87.59 (n)
  • 89.71 (a)
chicken
(Gallus gallus)
Aves SLC24A2 35
  • 75.54 (n)
  • 77.81 (a)
SLC24A2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC24A2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc24a2 35
  • 69.8 (n)
  • 72.73 (a)
zebrafish
(Danio rerio)
Actinopterygii SLC24A2 (1 of 2) 36
  • 66 (a)
OneToMany
SLC24A2 (2 of 2) 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nckx30C 35
  • 58.75 (n)
  • 58.5 (a)
Nckx30C 36
  • 36 (a)
OneToMany
Nckx30C 37
  • 52 (a)
CG1090 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea ncx-4 36
  • 45 (a)
ManyToMany
ncx-5 36
  • 41 (a)
ManyToMany
ncx-4 37
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SLC24A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC24A2 Gene

ENSEMBL:
Gene Tree for SLC24A2 (if available)
TreeFam:
Gene Tree for SLC24A2 (if available)

Paralogs for SLC24A2 Gene

Paralogs for SLC24A2 Gene

Selected SIMAP similar genes for SLC24A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC24A2: view

Variants for SLC24A2 Gene

Sequence variations from dbSNP and Humsavar for SLC24A2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs715253 -- 19,628,507(+) CCTTC(C/G)CCTGA intron-variant
rs715254 -- 19,628,719(+) GGTCT(A/G)AGACA intron-variant
rs718623 -- 19,628,635(+) TCACA(C/T)GAATT intron-variant
rs731407 -- 19,572,706(+) AATAC(A/C)TATGT intron-variant
rs748530 -- 19,639,715(+) CAAGT(C/T)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC24A2 Gene

Variant ID Type Subtype PubMed ID
nsv466286 CNV Gain 19166990
nsv524474 CNV Gain 19592680
nsv831524 CNV Gain+Loss 17160897
esv2671085 CNV Deletion 23128226
esv2667371 CNV Deletion 23128226
nsv415862 CNV Loss 16902084
esv22657 CNV Loss 19812545
esv2333274 CNV Deletion 18987734
nsv892703 CNV Gain 21882294
esv34141 CNV Loss 18971310
dgv8118n71 CNV Gain 21882294
nsv892706 CNV Loss 21882294
nsv892707 CNV Gain 21882294
nsv892708 CNV Loss 21882294
nsv507508 CNV Insertion 20534489
esv2559680 CNV Deletion 19546169
nsv512091 CNV Loss 21212237
esv2000234 CNV Deletion 18987734
esv2738265 CNV Deletion 23290073
esv2676649 CNV Deletion 23128226
esv25330 CNV Loss 19812545
nsv511417 CNV Loss 21212237
nsv892709 CNV Gain 21882294
nsv892710 CNV Gain 21882294

Relevant External Links for SLC24A2 Gene

HapMap Linkage Disequilibrium report
SLC24A2
Human Gene Mutation Database (HGMD)
SLC24A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC24A2 Gene

Disorders for SLC24A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC24A2 Gene including...

Search for SLC24A2 Gene in MalaCards »

Relevant External Links for SLC24A2

Genetic Association Database (GAD)
SLC24A2
Human Genome Epidemiology (HuGE) Navigator
SLC24A2
genes like me logo Genes that share disorders with SLC24A2: view

No data available for UniProtKB/Swiss-Prot for SLC24A2 Gene

Publications for SLC24A2 Gene

  1. Molecular cloning and functional expression of the potassium- dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors. (PMID: 10662833) Prinsen C.F.M. … Schnetkamp P.P.M. (J. Neurosci. 2000) 2 3 4
  2. Role of cysteine residues in the NCKX2 Na+/Ca(2+)-K+ Exchanger: generation of a functional cysteine-free exchanger. (PMID: 15196038) Kinjo T.G. … Schnetkamp P.P. (Biochemistry 2004) 3 23
  3. Scanning mutagenesis of the alpha repeats and of the transmembrane acidic residues of the human retinal cone Na/Ca-K exchanger. (PMID: 12525183) Winkfein R.J. … Schnetkamp P.P. (Biochemistry 2003) 3 23
  4. Topology of the retinal cone NCKX2 Na/Ca-K exchanger. (PMID: 12600216) Kinjo T.G. … Schnetkamp P.P. (Biochemistry 2003) 4 23
  5. Residues contributing to the Ca2+ and K+ binding pocket of the NCKX2 Na+/Ca2+-K+ exchanger. (PMID: 15583008) Kang K.J. … Schnetkamp P.P. (J. Biol. Chem. 2005) 3 23

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Sources for SLC24A2 Gene

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