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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC24A2 Gene

protein-coding   GIFtS: 51
GCID: GC09M019507

Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger),...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member
21 2
NCKX22 3 5
Retinal Cone Na-Ca+K Exchanger2 3
Na(+)/K(+)/Ca(2+)-Exchange Protein 22 3
Sodium/Potassium/Calcium Exchanger 22
Solute Carrier Family 24 Member 23

External Ids:    HGNC: 109761   Entrez Gene: 257692   Ensembl: ENSG000001558867   OMIM: 6098385   UniProtKB: Q9UI403   

Export aliases for SLC24A2 gene to outside databases

Previous GC identifers: GC09M019846 GC09M019704 GC09M019505 GC09M019468


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC24A2 Gene:
This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein
belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in
exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced
decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain
injury. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for SLC24A2 Gene: 
SLC24A2 (solute carrier family 24 (sodium/potassium/calcium exchanger), member 2) is a protein-coding gene. Diseases associated with SLC24A2 include brain injury, and retinitis, and among its related super-pathways are Sodium/Calcium exchangers and Transmembrane transport of small molecules. GO annotations related to this gene include calcium channel activity and protein dimerization activity. An important paralog of this gene is SLC24A3.

UniProtKB/Swiss-Prot: NCKX2_HUMAN, Q9UI40
Function: Critical component of the visual transduction cascade, controlling the calcium concentration of outer
segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment
of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via
this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in
exchange for 4 Na(+)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC24A2 gene promoter:
         AML1a   STAT5A   Tal-1beta   E47   YY1   FAC1   HSF2   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC24A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC24A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC24A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.1   Ensembl cytogenetic band:  9p22.1   HGNC cytogenetic band: 9p22.1

SLC24A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC24A2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M019507:  view genomic region     (about GC identifiers)

Start:
19,507,450 bp from pter      End:
19,788,591 bp from pter
Size:
281,142 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCKX2_HUMAN, Q9UI40 (See protein sequence)
Recommended Name: Sodium/potassium/calcium exchanger 2  
Size: 661 amino acids; 73664 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B7ZLL8 Q9NTN5 Q9NZQ4
Alternative splicing: 2 isoforms:  Q9UI40-1   Q9UI40-2   

Explore the universe of human proteins at neXtProt for SLC24A2: NX_Q9UI40

Explore proteomics data for SLC24A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UI40

  • SLC24A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC24A2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180217.1  NP_065077.1  

    ENSEMBL proteins: 
     ENSP00000344801   ENSP00000286344  
    Reactome Protein details: Q9UI40
    Human Recombinant Protein Products for SLC24A2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC24A2 for ontologies           About GeneDecksing



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    Assay Products for SLC24A2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/potassium/calcium exchanger 2 
    SLC24 family of sodium/potassium/calcium exchangers

    2 InterPro protein domains:
     IPR004481 K/Na/Ca-exchanger
     IPR004837 NaCa_Exmemb

    Graphical View of Domain Structure for InterPro Entry Q9UI40

    ProtoNet protein and cluster: Q9UI40

    1 Blocks protein domain: IPB004837 Sodium/calcium exchanger membrane region

    UniProtKB/Swiss-Prot: NCKX2_HUMAN, Q9UI40
    Similarity: Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily


    SLC24A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCKX2_HUMAN, Q9UI40
    Function: Critical component of the visual transduction cascade, controlling the calcium concentration of outer
    segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment
    of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via
    this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in
    exchange for 4 Na(+)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005262calcium channel activity IEA--
    GO:0015293symporter activity IEA--
    GO:0015297antiporter activity IEA--
    GO:0046983protein dimerization activity IEA--
         
    SLC24A2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc24a2):
     behavior/neurological  homeostasis/metabolism  nervous system  vision/eye 

    SLC24A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc24a2tm1Jlyt for SLC24A2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC24A2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC24A2 
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    miRNA
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    8/155 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC24A2 (see all 155):
    hsa-miR-194* hsa-miR-124* hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSLC24A2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC24A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC24A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sodium-coupled transporters and pumps
    Sodium/Calcium exchangers0.30
    Sodium-coupled transporters and pumps0.30
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    3Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    4Visual signal transduction- Rods
    Visual signal transduction- Cones0.39
    5Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SLC24A2
        Sodium-coupled transporters and pumps

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLC24A2
        Visual Cycle in Retinal Rods

    1 BioSystems Pathway for SLC24A2
        Visual signal transduction- Cones

    4        Reactome Pathways for SLC24A2
        Sodium/Calcium exchangers
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides



    SLC24A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC24A2

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006813potassium ion transport IEA--
    GO:0006814sodium ion transport IEA--
    GO:0006816calcium ion transport ----
    GO:0006874cellular calcium ion homeostasis IEA--

    SLC24A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC24A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC24A2 (NCKX2)

    2 HMDB Compounds for SLC24A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--

    2 Novoseek inferred chemical compound relationships for SLC24A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 22.7 3 17716241 (1)
    cysteine 14.5 4 15196038 (3)

    Search CenterWatch for drugs/clinical trials and news about SLC24A2 / NCKX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC24A2 gene (2 alternative transcripts): 
    NM_001193288.2  NM_020344.3  

    Unigene Clusters for SLC24A2:

    Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
    Hs.283014  [show with all ESTs], Hs.590750 , Hs.738749  [show with all ESTs]
    Unigene Representative Sequences: NM_020344, DQ067464, BP309913
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341998(uc003zoa.2) ENST00000286344(uc003zob.2)
    miRNA
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    8/155 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC24A2 (see all 155):
    hsa-miR-194* hsa-miR-124* hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSLC24A2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC24A2
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    Additional mRNA sequence: 

    DQ067462.1 DQ067463.1 

    5 DOTS entries:

    DT.430826  DT.92046410  DT.92046413  DT.40293866  DT.91687944 

    8 AceView cDNA sequences:

    AF177987 BC069622 AF097366 NM_020344 BP361339 AW837896 AW837895 CD630041 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC24A2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                            
    SP2:              -                                             


    ECgene alternative splicing isoforms for SLC24A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC24A2 expression in normal human tissues (normalized intensities)      SLC24A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTCATTC
    SLC24A2 Expression
    About this image


    SLC24A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             postcentral gyrus   
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Larynx (Respiratory System)

    See SLC24A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC24A2

    SOURCE GeneReport for Unigene clusters: Hs.283014 Hs.590750 Hs.738749
        SABiosciences Custom PCR Arrays for SLC24A2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC24A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC24A2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc24a21 , 5 solute carrier family 24 (sodium/potassium/calcium more1, 5 87.85(n)1
    90.17(a)1
      4 (40.69 cM)5
    763761  NM_172426.21  NP_766014.11 
     869831245 
    chicken
    (Gallus gallus)
    Aves SLC24A21 solute carrier family 24 (sodium/potassium/calcium more 75.44(n)
    77.5(a)
      414891  NM_001001772.1  NP_001001772.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC24A26
    solute carrier family 24 (sodium/potassium/calcium...
    73(a)
    1 ↔ 1
    2(62282114-62397912)
    zebrafish
    (Danio rerio)
    Actinopterygii SLC24A2 (1 of 2)6
    SLC24A2 (2 of 2)6
    solute carrier family 24 (sodium/potassium/calcium...
    solute carrier family 24 (sodium/potassium/calcium...
    67(a)
    65(a)
    1 ↔ many
    1 ↔ many
    7(76339344-76404022)
    1(11245714-11280431)
    fruit fly
    (Drosophila melanogaster)
    Insecta Nckx30C1 , 3 calcium, potassium:sodium antiporter3
    CG18660-PA1
    52(a)
    (best of 2)3
    57.58(n)1
    58.46(a)1
      452481  NM_001201832.11  NP_001188761.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ncx-43 Na/Ca,K exchanger 54(a)   I(9816958-9820866)   --


    ENSEMBL Gene Tree for SLC24A2 (if available)
    TreeFam Gene Tree for SLC24A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC24A2 gene
    SLC24A32  SLC24A52  SLC8B12  SLC24A42  SLC24A12  
    4 SIMAP similar genes for SLC24A2 using alignment to 1 protein entry:     NCKX2_HUMAN:
    SLC24A1    SLC24A4    SLC24A3    SLC24A5

    SLC24A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7117 SNPs in SLC24A2 are shown (see all 7117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs610197001,2
    C--19474624(+) TATAT-/AT/A  
      TAT
    /TG
    GTATA
    6 -- ut310--------
    rs674459061,2
    C--19479362(+) TTAAA-/AC/CA 
            
    ACACA
    2 -- int11NA 2
    rs107094561,2
    C--19480779(+) AGTGAT/-TTTTT 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1509386251,2
    C--19483315(+) TTTTC-/TTTTTT 2 -- int10--------
    rs2003719931,2
    --19483322(+) TTTTT-/CTCTTT 2 -- int10--------
    rs766729811,2
    F--19495899(-) TAGCAC/AACCAC 2 -- int12Minor allele frequency- A:0.50NA 6
    rs1476272921,2
    --19501980(+) TTTTTG/TACTTA 2 -- ds50010--------
    rs1834357141,2
    --19502090(+) ATCTCC/TGCAAT 2 -- ds50010--------
    rs1885426761,2
    --19502142(+) GGTCCC/TGATTA 2 -- ds50010--------
    rs1144415211,2
    C,F--19502235(+) ACTTAG/ATTACA 2 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for SLC24A2 (19507450 - 19757450 bp, first 250kb of SLC24A2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for SLC24A2 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667371CNV Deletion23128226
    esv2676649CNV Deletion23128226
    esv2671085CNV Deletion23128226
    esv2738265CNV Deletion23290073
    esv2333274CNV Deletion18987734
    esv2000234CNV Deletion18987734
    esv2559680CNV Deletion19546169
    nsv507508CNV Insertion20534489
    esv25330CNV Loss19812545
    esv22657CNV Loss19812545


    Human Gene Mutation Database (HGMD): SLC24A2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC24A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC24A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609838    OMIM disorders: --

    6 diseases for SLC24A2:    About MalaCards
    brain injury    retinitis    achromatopsia    ischemia
    cerebritis    neuronitis


    SLC24A2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC24A2
    Human Genome Epidemiology (HuGE) Navigator: SLC24A2 (10 documents)

    Export disorders for SLC24A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC24A2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with SLC24A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of the potassium- dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors. (PubMed id 10662833)1, 2, 3 Prinsen C.F.M.... Schnetkamp P.P.M. (2000)
    2. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (2009)
    3. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exchangers NCKX2, NCKX3, and NCKX4: identification of Thr-551 as a key residue in defining the apparent K(+) affinity of NCKX2. (PubMed id 17172467)1, 9 Visser F....Lytton J. (2007)
    7. Role of cysteine residues in the NCKX2 Na+/Ca(2+)-K+ Exchanger: generation of a functional cysteine-free exchanger. (PubMed id 15196038)1, 9 Kinjo T.G....Schnetkamp P.P. (2004)
    8. Ionic selectivity of NCKX2, NCKX3, and NCKX4 for monovalent cations at K+-binding site. (PubMed id 17446453)1, 9 Lee J.Y....Lee S.H. (2007)
    9. Involvement of the potassium-dependent sodium/calcium exchanger gene product NCKX2 in the brain insult induced by permanent focal cerebral ischemia. (PubMed id 17446491)1, 9 Cuomo O....Annunziato L. (2007)
    10. Structure-function relationships of the NCKX2 Na+/Ca2+-K+ exchanger. (PubMed id 17303823)1, 9 Shibukawa Y....Schnetkamp P.P. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25769 HGNC: 10976 AceView: SLC24A2 Ensembl:ENSG00000155886 euGenes: HUgn25769
    ECgene: SLC24A2 H-InvDB: SLC24A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC24A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC24A2 gene:
    Search GeneIP for patents involving SLC24A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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