Aliases for SLC24A2 Gene
External Ids for SLC24A2 Gene
Previous GeneCards Identifiers for SLC24A2 Gene
This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for SLC24A2 Gene
SLC24A2 (Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 2) is a Protein Coding gene. Diseases associated with SLC24A2 include brain injury. Among its related pathways are Visual Cycle in Retinal Rods and The phototransduction cascade. GO annotations related to this gene include protein dimerization activity and symporter activity. An important paralog of this gene is SLC24A4.
UniProtKB/Swiss-Prot for SLC24A2 Gene
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)