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SLC24A2 Gene

protein-coding   GIFtS: 52
GCID: GC09M019507

Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger),...

  See SLC24A2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member
21 2
NCKX22 3 5
Retinal Cone Na-Ca+K Exchanger2 3
Na(+)/K(+)/Ca(2+)-Exchange Protein 22 3
Sodium/Potassium/Calcium Exchanger 22
Solute Carrier Family 24 Member 23

External Ids:    HGNC: 109761   Entrez Gene: 257692   Ensembl: ENSG000001558867   OMIM: 6098385   UniProtKB: Q9UI403   

Export aliases for SLC24A2 gene to outside databases

Previous GC identifers: GC09M019846 GC09M019704 GC09M019505 GC09M019468


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC24A2 Gene:
This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein
belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in
exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced
decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain
injury. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for SLC24A2 Gene:
SLC24A2 (solute carrier family 24 (sodium/potassium/calcium exchanger), member 2) is a protein-coding gene. Diseases associated with SLC24A2 include brain injury. GO annotations related to this gene include protein dimerization activity and symporter activity. An important paralog of this gene is SLC24A3.

UniProtKB/Swiss-Prot: NCKX2_HUMAN, Q9UI40
Function: Critical component of the visual transduction cascade, controlling the calcium concentration of outer
segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment
of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via
this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in
exchange for 4 Na(+)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC24A2 gene promoter:
         AML1a   STAT5A   Tal-1beta   E47   YY1   FAC1   HSF2   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC24A2 promoter sequence
   Search Chromatin IP Primers for SLC24A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC24A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.1   Ensembl cytogenetic band:  9p22.1   HGNC cytogenetic band: 9p22.1

SLC24A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC24A2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M019507:  view genomic region     (about GC identifiers)

Start:
19,507,450 bp from pter      End:
19,788,591 bp from pter
Size:
281,142 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NCKX2_HUMAN, Q9UI40 (See protein sequence)
Recommended Name: Sodium/potassium/calcium exchanger 2  
Size: 661 amino acids; 73664 Da
Secondary accessions: B7ZLL8 Q9NTN5 Q9NZQ4
Alternative splicing: 2 isoforms:  Q9UI40-1   Q9UI40-2   

Explore the universe of human proteins at neXtProt for SLC24A2: NX_Q9UI40

Explore proteomics data for SLC24A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn111
  • Modification sites at PhosphoSitePlus

  • See SLC24A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180217.1  NP_065077.1  

    ENSEMBL proteins: 
     ENSP00000344801   ENSP00000286344  
    Reactome Protein details: Q9UI40

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    antibodies-online peptides for SLC24A2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/potassium/calcium exchanger 2
    SLC24 family of sodium/potassium/calcium exchangers

    2 InterPro protein domains:
     IPR004481 K/Na/Ca-exchanger
     IPR004837 NaCa_Exmemb

    Graphical View of Domain Structure for InterPro Entry Q9UI40

    ProtoNet protein and cluster: Q9UI40

    1 Blocks protein domain: IPB004837 Sodium/calcium exchanger membrane region

    UniProtKB/Swiss-Prot: NCKX2_HUMAN, Q9UI40
    Similarity: Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily


    Find genes that share domains with SLC24A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCKX2_HUMAN, Q9UI40
    Function: Critical component of the visual transduction cascade, controlling the calcium concentration of outer
    segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment
    of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via
    this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in
    exchange for 4 Na(+)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005262calcium channel activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008273calcium, potassium:sodium antiporter activity IDA18166528
    GO:0015293symporter activity IEA--
    GO:0016151nickel cation binding IEA--
         
    Find genes that share ontologies with SLC24A2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc24a2):
     behavior/neurological  homeostasis/metabolism  nervous system  vision/eye 

    Find genes that share phenotypes with SLC24A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc24a2tm1Jlyt for SLC24A2

       genOway: Develop your customized and physiologically relevant rodent model for SLC24A2

    miRNA
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    hsa-miR-194* hsa-miR-124* hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSLC24A2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCKX2_HUMAN, Q9UI40: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031226intrinsic component of plasma membrane IEA--

    Find genes that share ontologies with SLC24A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC24A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    Sodium/Calcium exchangers0.00
    2The phototransduction cascade
    Visual signal transduction- Cones0.39
    3Visual Cycle in Retinal Rods
    Visual Cycle in Retinal Rods
    4Sodium coupled transporters and pumps
    Sodium coupled transporters and pumps


    Find genes that share SuperPaths with SLC24A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC24A2
        Visual Cycle in Retinal Rods

    1 BioSystems Pathway for SLC24A2
        Visual signal transduction- Cones

    1 Reactome Pathway for SLC24A2
        Sodium/Calcium exchangers


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC24A2
    Interactions:

        Search GeneGlobe Interaction Network for SLC24A2

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006816calcium ion transport ----
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0007601visual perception IEA--
    GO:0007612learning IEA--

    Find genes that share ontologies with SLC24A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC24A2 (NCKX2)

    2 HMDB Compounds for SLC24A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--

    2 Novoseek inferred chemical compound relationships for SLC24A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 22.7 3 17716241 (1)
    cysteine 14.5 4 15196038 (3)



    Find genes that share compounds with SLC24A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC24A2 gene (2 alternative transcripts): 
    NM_001193288.2  NM_020344.3  

    Unigene Clusters for SLC24A2:

    Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
    Hs.283014  [show with all ESTs], Hs.590750
    Unigene Representative Sequences: NM_020344, DQ067464
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341998(uc003zoa.2) ENST00000286344(uc003zob.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC24A2 (see all 155):
    hsa-miR-194* hsa-miR-124* hsa-miR-361-5p hsa-miR-199a-3p hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-877*
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      QuantiFast Probe-based Assays in human, mouse, rat SLC24A2

    Additional mRNA sequence: DQ067464.1 

    5 DOTS entries:

    DT.430826  DT.92046410  DT.40293866  DT.92046413  DT.91687944 

    8 AceView cDNA sequences:

    AF097366 BC069622 AF177987 NM_020344 BP361339 AW837896 AW837895 CD630041 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC24A2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                            
    SP2:              -                                             


    ECgene alternative splicing isoforms for SLC24A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC24A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTCATTC
    SLC24A2 Expression
    About this image


    SLC24A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Larynx (Respiratory System)
    SLC24A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC24A2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.283014 Hs.590750
        Custom PCR Arrays for SLC24A2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC24A2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc24a21 , 5 solute carrier family 24 (sodium/potassium/calcium more1, 5 87.85(n)1
    90.17(a)1
      4 (40.69 cM)5
    763761  NM_172426.21  NP_766014.11 
     869831245 
    chicken
    (Gallus gallus)
    Aves SLC24A21 solute carrier family 24 (sodium/potassium/calcium more 75.54(n)
    77.81(a)
      414891  NM_001001772.1  NP_001001772.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC24A26
    solute carrier family 24 (sodium/potassium/calcium...
    74(a)
    1 ↔ 1
    2(62282114-62397912)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc24a21 solute carrier family 24 (sodium/potassium/calcium more 69.8(n)
    72.73(a)
      100494112  XM_002935665.2  XP_002935711.2 
    zebrafish
    (Danio rerio)
    Actinopterygii SLC24A2 (2 of 2)6
    SLC24A2 (1 of 2)6
    solute carrier family 24 (sodium/potassium/calcium...
    solute carrier family 24 (sodium/potassium/calcium...
    69(a)
    66(a)
    1 ↔ many
    1 ↔ many
    7(76339344-76404022) ENSDARG00000063158
    1(11245714-11280431) ENSDARG00000042988
    fruit fly
    (Drosophila melanogaster)
    Insecta Nckx30C1 , 3 calcium, potassium:sodium antiporter3
    Nckx30C1
    52(a)
    (best of 2)3
    58.75(n)1
    58.5(a)1
      452481  NM_001201832.21  NP_001188761.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ncx-43 Na/Ca,K exchanger 54(a)   I(9816958-9820866)   --


    ENSEMBL Gene Tree for SLC24A2 (if available)
    TreeFam Gene Tree for SLC24A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC24A2 gene
    SLC24A32  SLC24A52  SLC8B12  SLC24A42  SLC24A12  
    4 SIMAP similar genes for SLC24A2 using alignment to 1 protein entry:     NCKX2_HUMAN:
    SLC24A1    SLC24A4    SLC24A3    SLC24A5

    Find genes that share paralogs with SLC24A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC24A2 (see all 7117)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs610197001,2
    C--19474624(+) TATAT-/AT/A  
      TAT
    /TG
    GTATA
    6 -- ut310--------
    rs674459061,2
    C--19479362(+) TTAAA-/AC/CA 
            
    ACACA
    2 -- int11NA 2
    rs107094561,2
    C--19480779(+) AGTGAT/-TTTTT 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1509386251,2
    C--19483315(+) TTTTC-/TTTTTT 2 -- int10--------
    rs2003719931,2
    --19483322(+) TTTTT-/CTCTTT 2 -- int10--------
    rs766729811,2
    F--19495899(-) TAGCAC/AACCAC 2 -- int12Minor allele frequency- A:0.50NA 6
    rs1476272921,2
    --19501980(+) TTTTTG/TACTTA 2 -- ds50010--------
    rs1834357141,2
    --19502090(+) ATCTCC/TGCAAT 2 -- ds50010--------
    rs1885426761,2
    --19502142(+) GGTCCC/TGATTA 2 -- ds50010--------
    rs1144415211,2
    C,F--19502235(+) ACTTAG/ATTACA 2 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for SLC24A2 (19507450 - 19757450 bp, first 250kb of SLC24A2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC24A2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667371CNV Deletion23128226
    esv2676649CNV Deletion23128226
    esv2671085CNV Deletion23128226
    esv2738265CNV Deletion23290073
    esv2333274CNV Deletion18987734
    esv2000234CNV Deletion18987734
    esv2559680CNV Deletion19546169
    nsv507508CNV Insertion20534489
    esv25330CNV Loss19812545
    esv22657CNV Loss19812545

    Human Gene Mutation Database (HGMD): SLC24A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC24A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC24A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609838    OMIM disorders: --

    1 disease for SLC24A2:    
    About MalaCards
    brain injury


    Find genes that share disorders with SLC24A2           About GenesLikeMe

    Genetic Association Database (GAD): SLC24A2
    Human Genome Epidemiology (HuGE) Navigator: SLC24A2 (10 documents)

    Export disorders for SLC24A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC24A2 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with SLC24A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of the potassium- dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors. (PubMed id 10662833)1, 2, 3 Prinsen C.F.M.... Schnetkamp P.P.M. (J. Neurosci. 2000)
    2. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exchangers NCKX2, NCKX3, and NCKX4: identification of Thr-551 as a key residue in defining the apparent K(+) affinity of NCKX2. (PubMed id 17172467)1, 9 Visser F....Lytton J. (J. Biol. Chem. 2007)
    7. Role of cysteine residues in the NCKX2 Na+/Ca(2+)-K+ Exchanger: generation of a functional cysteine-free exchanger. (PubMed id 15196038)1, 9 Kinjo T.G....Schnetkamp P.P. (Biochemistry 2004)
    8. Ionic selectivity of NCKX2, NCKX3, and NCKX4 for monovalent cations at K+-binding site. (PubMed id 17446453)1, 9 Lee J.Y....Lee S.H. (Ann. N. Y. Acad. Sci. 2007)
    9. Involvement of the potassium-dependent sodium/calcium exchanger gene product NCKX2 in the brain insult induced by permanent focal cerebral ischemia. (PubMed id 17446491)1, 9 Cuomo O....Annunziato L. (Ann. N. Y. Acad. Sci. 2007)
    10. Structure-function relationships of the NCKX2 Na+/Ca2+-K+ exchanger. (PubMed id 17303823)1, 9 Shibukawa Y....Schnetkamp P.P. (Ann. N. Y. Acad. Sci. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25769 HGNC: 10976 AceView: SLC24A2 Ensembl:ENSG00000155886 euGenes: HUgn25769
    ECgene: SLC24A2 H-InvDB: SLC24A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC24A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC24A2 gene:
    Search GeneIP for patents involving SLC24A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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