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Aliases for SLC23A3 Gene

Aliases for SLC23A3 Gene

  • Solute Carrier Family 23, Member 3 2 3
  • Sodium-Dependent Vitamin C Transporter 3 3 4
  • Na(+)/L-Ascorbic Acid Transporter 3 3 4
  • HPC E2-Binding Protein 3 3 4
  • E2BP3 3 4
  • SVCT3 3 4
  • Solute Carrier Family 23 (Nucleobase Transporters), Member 3 3
  • Solute Carrier Family 23 Member 3 3
  • E2-Binding Protein 3 3
  • Yspl1 3

External Ids for SLC23A3 Gene

Previous GeneCards Identifiers for SLC23A3 Gene

  • GC02M218662
  • GC02M219905
  • GC02M220143
  • GC02M220228
  • GC02M219766
  • GC02M219851
  • GC02M219649
  • GC02M219940
  • GC02M211879

Summaries for SLC23A3 Gene

GeneCards Summary for SLC23A3 Gene

SLC23A3 (Solute Carrier Family 23, Member 3) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SLC23A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC23A3 Gene

Genomics for SLC23A3 Gene

Regulatory Elements for SLC23A3 Gene

Genomic Location for SLC23A3 Gene

219,075,329 bp from pter
219,170,827 bp from pter
95,499 bases
Minus strand

Genomic View for SLC23A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC23A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC23A3 Gene

Proteins for SLC23A3 Gene

  • Protein details for SLC23A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 23 member 3
    Protein Accession:
    Secondary Accessions:
    • B7Z512
    • Q2PYN6
    • Q96NA6

    Protein attributes for SLC23A3 Gene

    610 amino acids
    Molecular mass:
    64531 Da
    Quaternary structure:
    No Data Available
    • Sequence=ABC17635.1; Type=Miscellaneous discrepancy; Note=Fragment of a potential novel isoform.; Evidence={ECO:0000305}; Sequence=BAB70999.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC23A3 Gene


neXtProt entry for SLC23A3 Gene

Proteomics data for SLC23A3 Gene at MOPED

Post-translational modifications for SLC23A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC23A3 Gene

Domains for SLC23A3 Gene

Gene Families for SLC23A3 Gene

Protein Domains for SLC23A3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q6PIS1
  • Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
genes like me logo Genes that share domains with SLC23A3: view

Function for SLC23A3 Gene

Gene Ontology (GO) - Molecular Function for SLC23A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SLC23A3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC23A3 Gene

Localization for SLC23A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC23A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC23A3 Gene COMPARTMENTS Subcellular localization image for SLC23A3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC23A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC23A3: view

Pathways for SLC23A3 Gene

SuperPathways for SLC23A3 Gene

No Data Available

Interacting Proteins for SLC23A3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000406546 Q6PIS1-S23A3_HUMAN for SLC23A3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC23A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC23A3: view

No data available for Pathways by source for SLC23A3 Gene

Compounds for SLC23A3 Gene

(1) HMDB Compounds for SLC23A3 Gene

Compound Synonyms Cas Number PubMed IDs
Ascorbic acid
  • (+)-ascorbate
genes like me logo Genes that share compounds with SLC23A3: view

Transcripts for SLC23A3 Gene

Unigene Clusters for SLC23A3 Gene

Solute carrier family 23 (nucleobase transporters), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC23A3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC23A3 Gene

No ASD Table

Relevant External Links for SLC23A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC23A3 Gene

mRNA expression in normal human tissues for SLC23A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC23A3 Gene

This gene is overexpressed in Kidney - Cortex (7.5) and Small Intestine - Terminal Ileum (6.7).

Protein differential expression in normal tissues for SLC23A3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC23A3 Gene

SOURCE GeneReport for Unigene cluster for SLC23A3 Gene Hs.124565

genes like me logo Genes that share expressions with SLC23A3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC23A3 Gene

Orthologs for SLC23A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC23A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC23A3 35
  • 85.11 (n)
  • 80.36 (a)
SLC23A3 36
  • 79 (a)
(Canis familiaris)
Mammalia SLC23A3 35
  • 86.52 (n)
  • 82.65 (a)
SLC23A3 36
  • 82 (a)
(Mus musculus)
Mammalia Slc23a3 35
  • 82.37 (n)
  • 78.75 (a)
Slc23a3 16
Slc23a3 36
  • 78 (a)
(Pan troglodytes)
Mammalia SLC23A3 35
  • 99.57 (n)
  • 99.19 (a)
SLC23A3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc23a3 35
  • 81.71 (n)
  • 77.43 (a)
(Monodelphis domestica)
Mammalia SLC23A3 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
(Gallus gallus)
Aves SLC23A3 35
  • 58.89 (n)
  • 52.99 (a)
SLC23A3 36
  • 50 (a)
(Anolis carolinensis)
Reptilia SLC23A3 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc23a3 35
  • 54.45 (n)
  • 46.02 (a)
(Danio rerio)
Actinopterygii LOC100333020 35
  • 50.14 (n)
  • 45 (a)
slc23a3 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea C51E3.6 36
  • 25 (a)
R11E3.2 36
  • 22 (a)
T07G12.2 36
  • 22 (a)
T07G12.5 36
  • 21 (a)
Y59E9AL.4 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for SLC23A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC23A3 Gene

Gene Tree for SLC23A3 (if available)
Gene Tree for SLC23A3 (if available)

Paralogs for SLC23A3 Gene

Paralogs for SLC23A3 Gene

Selected SIMAP similar genes for SLC23A3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC23A3: view

Variants for SLC23A3 Gene

Sequence variations from dbSNP and Humsavar for SLC23A3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3795986 -- 219,169,108(+) CTAGG(A/G)AAAGT intron-variant
rs6436121 -- 219,169,234(+) AATTC(C/T)GCACC intron-variant
rs6753739 -- 219,164,178(+) TGATC(A/G)GGCCA intron-variant
rs7570721 -- 219,168,092(+) TCTGA(A/G)CCAGC intron-variant
rs7575555 -- 219,163,985(+) GTGTG(A/G)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC23A3 Gene

Variant ID Type Subtype PubMed ID
nsv875868 CNV Gain 21882294
nsv508200 CNV Loss 20534489

Relevant External Links for SLC23A3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC23A3 Gene

Disorders for SLC23A3 Gene

Relevant External Links for SLC23A3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SLC23A3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC23A3 Gene

Publications for SLC23A3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for SLC23A3 Gene

Sources for SLC23A3 Gene

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