SLC23A2 Gene
protein-coding GIFtS : 57
GC20M004781
solute carrier family 23 (nucleobase transporters), member 2 (Previous names: solute carrier family 23 (nucleobase transporters), member 1 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: SLC23A1 )
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Aliases & Descriptions for SLC23A2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KIAA0238 1 , 2 , 3 NBTL1 2 , 3 OTTHUMP00000030173 2 OTTHUMP00000030174 2 SLC23A1 2 , 3 SVCT2 1 , 2 , 3 , 5 YSPL2 1 , 2 , 3 hSVCT2 3
Descriptions Na(+)/L-ascorbic acid transporter 2 2 , 3 Nucleobase transporter-like 1 protein 3 Sodium-dependent vitamin C transporter 2 3 Yolk sac permease-like molecule 2 2 , 3 sodium-dependent vitamin C transporter-2 2 solute carrier family 23 (nucleobase transporters), member 1 1 , 2 solute carrier family 23 (nucleobase transporters), member 2 2
Search outside databases for aliases for SLC23A2 genePrevious GC identifers: GC05U990085 GC20M004783 GC20M004832 GC20M004828
Summaries for SLC23A2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for SLC23A2 : The absorption of vitamin C into the body and its distribution to organs requires twosodium-dependent vitamin C transporters. This gene encodes one of the two required transportersand the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this genehad an official symbol of SLC23A1. [provided by RefSeq] UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3 Function : Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with astoichiometry of 2 Na(+) for each ascorbate
Genomic Location for SLC23A2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the SLC23A2 gene Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13 SLC23A2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M004781:
(about GC identifiers )
Start:
4,781,002 bp from pter
End:
4,938,939 bp from pter
Size:
157,938 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000020.9 NT_011387.8 Proteins for SLC23A2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3 (See
protein sequence )Recommended Name: Solute carrier family 23 member 2 Size : 650 amino acids; 70337 Da
Subcellular location : Membrane; Multi-pass membrane protein
Secondary accessions : Q8WWR4 Q92512 Q96D54 Q9UNU1 Q9UP85
Post-translational modifications:
Phosphorylated (Probable)1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_005107.4 NP_976072.1 ENSEMBL proteins: ENSP00000368628 ENSP00000344322 ENSP00000368637 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for SLC23A2: Assays for SLC23A2:
Protein
Domains/ Families for SLC23A2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UGH3 ProtoNet protein and cluster: Q9UGH3
1 Blocks protein family : IPB006042 Xanthine/uracil permease family UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3 Similarity : Belongs to the xanthine/uracil permease family. SLC23A subfamily
Gene Function for SLC23A2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005116 Applied Biosystems Silencer ® siRNAs for SLC23A2 Sigma-Aldrich siRNA and siRNA Panels for SLC23A2 Sigma-Aldrich shRNA for SLC23A2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_005116                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_005116                                  untagged cDNA clones in CMV expression vector (see all 3 ): AK025668  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_203327 UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3 Function : Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with astoichiometry of 2 Na(+) for each ascorbate
Genatlas biochemistry entry for SLC23A2 :solute carrier family 23,member 2 (nucleobase transport),mainly expressed in kidney,liver,intestine
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Slc23a2) :5 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for SLC23A2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for SLC23A2 (ENSP00000344322 3 ) via UniProtKB, MINT, and/or STRING About this table 5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
):
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Drugs & Compounds for SLC23A2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Sigma-Aldrich Small Molecules for SLC23A2:Antagonist
Browse Tocris compounds for SLC23A2 2 Novoseek chemical compound relationships for SLC23A2 gene
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Transcripts for SLC23A2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005116 Sigma-Aldrich siRNA and siRNA Panels for SLC23A2 Sigma-Aldrich shRNA for SLC23A2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005116 NM_203327
REFSEQ mRNAs for SLC23A2 gene (2 alternative transcripts): NM_005116.5 NM_203327.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005116 NM_203327
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_005116                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_005116                                  untagged cDNA clones in CMV expression vector (see all 3 ): AK025668  
Additional cDNA sequence: AB075494.1 AF058319.1 AF092511.1 AF164142.1 AJ269478.1 AJ292318.1 AK025668.1 AK296304.1 AK297253.1 AY380556.1 BC013112.2 BC073895.1 D87075.2 DQ011866.1 EF032501.1
17 DOTS entries : DT.87016611 DT.100000350 DT.100722970 DT.95163565 DT.92437958 DT.92437953 DT.120809847 DT.91987360 DT.95163567 DT.100817059 DT.40117140 DT.100657065 DT.100817060 DT.100026927 DT.75151236 DT.95163566 DT.95321997
24/234 AceView cDNA sequences (see all 234
):CA389030 BQ899222 BX283621 AA347858 BM703038 AW140065 BM973710 CA396546 AV707484 BE047928 NM_203327 AA782627 BQ068884 BQ214524 AU140378 AI916298 BM709956 AA075501 AA323329 AI056144 AA460499 AI804060 D87075 CA394378
highest scoring ESTs for SLC23A2 :AF164142 BC013112 BE893514 D87075 AA000999 AA001558 AA007420 AA007487 AA012920 AA013005
Unigene Cluster for SLC23A2: Solute carrier family 23 (nucleobase transporters), member 2 Hs.516866 [show with all ESTs ] Unigene Representative Sequence: NM_203327 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC23A2 (see all 6
) ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 SP1 :       -   -   -                         -     -             SP2 :       -   -   -                         -                 SP3 :       -   -   -                                         SP4 :           -                                         SP5 :                                                  
About this scheme ECgene alternative splicing isoforms for SLC23A2 3 Ensembl transcripts including schematic representations : ENST00000379324
ENST00000338244
ENST00000379333
Expression for SLC23A2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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SLC23A2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for SLC23A2 1 / 2 / 3
8 probe-sets matching SLC23A2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCTTCATTAASOURCE GeneReport for Unigene cluster: Hs.516866 UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3 Tissue specificity : Ubiquitous
Orthologs for SLC23A2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for SLC23A2 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for SLC23A2 ENSEMBL Gene Tree for SLC23A2 Paralogs for SLC23A2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for SLC23A2 gene SLC23A1 2 SLC23A3 2
SNPs/Variants for SLC23A2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for SLC23A2 (up to first 250kb)
Disorders & Mutations for SLC23A2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 603791 Human Genome Epidemiology Navigator: SLC23A2 (7 documents)
Medical News for SLC23A2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for SLC23A2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/64 PubMed articles for SLC23A2 gene (see all 64
): Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters. (PubMed id 9804989) 2, 3, 4 Faaland C.A....Holtzman E.J. (1998) Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. (PubMed id 10471399) 1, 3, 4 Rajan D.P.... Prasad P.D. (1999) Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. (PubMed id 10556521) 1, 3, 4 Daruwala R.C.... Levine M. (1999) A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. (PubMed id 10395795) 1, 3, 4 Hogue D.L. and Ling V. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954) 3, 4 Nakajima D.... Nagase T. (2002) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 3, 4 Deloukas P....Rogers J. (2001) Vitamin C transport systems of mammalian cells. (PubMed id 11396616) 3, 4 Liang W.J.... Jarvis S.M. (2001) A family of mammalian Na+-dependent L-ascorbic acid transporters. (PubMed id 10331392) 2, 3 Tsukaguchi H....Hediger M.A. (1999) Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502) 3, 4 Nagase T....Nomura N. (1996)
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Genome Databases showing SLC23A2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing SLC23A2
(According to HUGE )
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Specialized Databases showing SLC23A2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for SLC23A2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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