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SLC23A2 Gene

protein-coding   GIFtS: 57

GC20M004781
solute carrier family 23 (nucleobase transporters), member 2
(Previous names: solute carrier family 23 (nucleobase transporters), member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SLC23A1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
KIAA0238 1, 2, 3
NBTL1 2, 3
OTTHUMP00000030173 2
OTTHUMP00000030174 2
SLC23A1 2, 3
SVCT2 1, 2, 3, 5
YSPL2 1, 2, 3
hSVCT2 3
Descriptions
Na(+)/L-ascorbic acid transporter 2 2, 3
Nucleobase transporter-like 1 protein 3
Sodium-dependent vitamin C transporter 2 3
Yolk sac permease-like molecule 2 2, 3
sodium-dependent vitamin C transporter-2 2
solute carrier family 23 (nucleobase transporters), member
1 1, 2
solute carrier family 23 (nucleobase transporters), member
2 2
External Ids
HGNC: 109731
Entrez Gene: 99622
UniProtKB: Q9UGH33
Ensembl: ENSG000000890577
Search outside databases for aliases for SLC23A2 gene

Previous GC identifers: GC05U990085 GC20M004783 GC20M004832 GC20M004828

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC23A2:
The absorption of vitamin C into the body and its distribution to organs requires two
sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters
and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene
had an official symbol of SLC23A1. [provided by RefSeq]

UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3
Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a
stoichiometry of 2 Na(+) for each ascorbate

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SLC23A2 gene  

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SLC23A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M004781:     (about GC identifiers)

Start:
4,781,002 bp from pter
End:
4,938,939 bp from pter
Size:
157,938 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000020.9  NT_011387.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3 (See protein sequence)
Recommended Name: Solute carrier family 23 member 2  
Size: 650 amino acids; 70337 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q8WWR4 Q92512 Q96D54 Q9UNU1 Q9UP85

Post-translational modifications:

  • Phosphorylated (Probable)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_005107.4  NP_976072.1  


    ENSEMBL proteins: 
    ENSP00000368628 ENSP00000344322 ENSP00000368637 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SLC23A2)
    Human Recombinant Proteins from Abnova (SLC23A2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction TAS9804989
    GO:0005887 integral to plasma membrane TAS9804989
    GO:0016020 membrane IEA--
    About this table

    Antibodies for SLC23A2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SLC23A2), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for SLC23A2

    Assays for SLC23A2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR006042 Xan_ur_permease
     IPR006043 Xant/urac/vitC


       GeneDecks  SLC23A2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UGH3

    ProtoNet protein and cluster: Q9UGH3

    1 Blocks protein family: IPB006042 Xanthine/uracil permease family

    UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3
    Similarity: Belongs to the xanthine/uracil permease family. SLC23A subfamily

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SLC23A2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SLC23A2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005116

                  Applied Biosystems Silencer® siRNAs for SLC23A2

                  Sigma-Aldrich siRNA and siRNA Panels for SLC23A2  
                         Sigma-Aldrich shRNA for SLC23A2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for SLC23A2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005116
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005116
                                     untagged cDNA clones in CMV expression vector (see all 3): AK025668 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_203327

    UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3
    Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a
    stoichiometry of 2 Na(+) for each ascorbate

    Genatlas biochemistry entry for SLC23A2:
    solute carrier family 23,member 2 (nucleobase transport),mainly expressed in kidney,liver,intestine

    6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc23a2):

    endocrine/exocrine glandhomeostasis/metabolismlethality-prenatal/perinatalnervous system
    respiratory system

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215 transporter activity IEA--
    GO:0008523 sodium-dependent multivitamin transmembrane transporter activity NAS10471399
    GO:0015205 nucleobase transmembrane transporter activity TAS9804989
    GO:0015293 symporter activity IEA--
    GO:0031402 sodium ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for SLC23A2 (ENSP000003443223) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A1ENSP000003615793STRING (score=.732)
    About this table

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process TAS9804989
    GO:0006811 ion transport IEA--
    GO:0006814 sodium ion transport IEA--
    GO:0015851 nucleobase transport TAS9804989
    GO:0015993 molecular hydrogen transport NAS10471399
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for SLC23A2:
    Antagonist

    Browse Tocris compounds for SLC23A2
    2 Novoseek chemical compound relationships for SLC23A2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 16.36 5 15921655 (1), 12381735 (1), 14993613 (1), 19125272 (1)
    calcium 0.00 2 12788230 (2)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SLC23A2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SLC23A2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005116

                  Sigma-Aldrich siRNA and siRNA Panels for SLC23A2  
                         Sigma-Aldrich shRNA for SLC23A2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005116  NM_203327  

    REFSEQ mRNAs for SLC23A2 gene (2 alternative transcripts): 

    NM_005116.5   NM_203327.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005116  NM_203327  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005116
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005116
                                     untagged cDNA clones in CMV expression vector (see all 3): AK025668 

    Additional cDNA sequence: 

    AB075494.1 AF058319.1 AF092511.1 AF164142.1 AJ269478.1 AJ292318.1 AK025668.1 AK296304.1 
    AK297253.1 AY380556.1 BC013112.2 BC073895.1 D87075.2 DQ011866.1 EF032501.1 

    17 DOTS entries:

    DT.87016611  DT.100000350  DT.100722970  DT.95163565  DT.92437958  DT.92437953  DT.120809847  DT.91987360 
    DT.95163567  DT.100817059  DT.40117140  DT.100657065  DT.100817060  DT.100026927  DT.75151236  DT.95163566 
    DT.95321997 

    24/234 AceView cDNA sequences (see all 234 ):

    CA389030 BQ899222 BX283621 AA347858 BM703038 AW140065 BM973710 CA396546 
    AV707484 BE047928 NM_203327 AA782627 BQ068884 BQ214524 AU140378 AI916298 
    BM709956 AA075501 AA323329 AI056144 AA460499 AI804060 D87075 CA394378 

    highest scoring ESTs for SLC23A2:

    AF164142 BC013112 BE893514 D87075 AA000999 AA001558 AA007420 AA007487 AA012920 AA013005 

    Unigene Cluster for SLC23A2:

    Solute carrier family 23 (nucleobase transporters), member 2
    Hs.516866  [show with all ESTs]
    Unigene Representative Sequence: NM_203327


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC23A2 (see all 6 )

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                    -     -     -                                                                       -           -                                 
    SP2:                    -     -     -                                                                       -                                             
    SP3:                    -     -     -                                                                                                                     
    SP4:                                -                                                                                                                     
    SP5:                                                                                                                                                      

    About this scheme

    ECgene alternative splicing isoforms for SLC23A2

    3 Ensembl transcripts including schematic representations:
    ENST00000379324  ENST00000338244  ENST00000379333  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SLC23A2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SLC23A2

    1 / 2 / 3

    8 probe-sets matching SLC23A2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38122_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D87075 0.80 1.00 0.91 1

    211572_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF092511 0.60 1.00 0.82 1

    209236_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    209237_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF164142 0.80 1.00 0.91 1

    211572_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554692_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    209236_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    209237_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SLC23A2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCTTCATTAA

    SOURCE GeneReport for Unigene cluster: Hs.516866

    UniProtKB/Swiss-Prot: S23A2_HUMAN, Q9UGH3
    Tissue specificity: Ubiquitous

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for SLC23A2 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SLC23A11   -- solute carrier family 23 (nucleobase transporters), more 90.55(n)
    98.46(a)
    403490  XM_534357.2  XP_534357.2 
    chimpanzee
    (Pan troglodytes)
    SLC23A11   -- solute carrier family 23 (nucleobase transporters), more 99.23(n)
    100(a)
    458079  XM_001164748.1  XP_001164748.1 
    cow
    (Bos taurus)
    SLC23A21   -- similar to Solute carrier family 23 member 2 (Sodium-dependent more 91.2(n)
    98.15(a)
    783536  XM_001251156.1  XP_001251157.1 
    rat
    (Rattus norvegicus)
    Slc23a21   -- solute carrier family 23 (nucleobase transporters), more 88.44(n)
    95.94(a)
    50622  NM_017316.1  NP_059012.1 
    mouse
    (Mus musculus)
    Slc23a21, 5 25
    solute carrier family 23 (nucleobase transporters), more1, 5 88.15(n)1
    95.05(a)1
    543381  NM_018824.21  NP_061294.21 
     AB0381455  AI8447365  (see all 11)
    About this table        Species with no ortholog for SLC23A2

    ENSEMBL Gene Tree for SLC23A2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SLC23A2 gene
    SLC23A12  SLC23A32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1227 NCBI SNPs in SLC23A2 are shown (see all 1227 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 355)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs11313821,2
    A,C,F,H,O4782338(-) TTTATA/GCTGTA 2 -- ut3113Minor allele frequency- G:0.43MN EU EA WA NA 1238
    rs12796831,2
    A,C,F,H4931092(+) AAACCG/ATTGTC 2 -- ng31 int19Minor allele frequency- A:0.45MN EU EA WA NA 958
    rs65159641,2
    A,C,F,H4939090(+) acaccG/Atccca 1 -- ng317Minor allele frequency- A:0.01EU EA WA NA 524
    rs60529371,2
    A,C,F,H4783338(+) TGATAC/AAACCC 2 -- ut31 ese37Minor allele frequency- A:0.37EU EA WA NA 562
    --
    rs22549641,2
    A,C,F,H4930772(+) ttgtcC/Gccagg 2 -- ng31 int14Minor allele frequency- G:0.18EU EA WA 412
    rs60529351,2
    A,C,F,H4781623(+) TGGCCG/CTTCTT 2 -- ut31 ese38Minor allele frequency- C:0.06EU EA WA 838
    rs169903141,2
    C,F,H4785159(+) ATACTA/GGTGCC 2 -- ut31 ese37Minor allele frequency- G:0.13NA EU EA WA 560
    rs169903091,2
    C,F,H4784440(+) GGCTCC/TGGTCC 2 -- ut31 ese315Minor allele frequency- T:0.32NA EU EA WA 1400
    rs60530011,2
    C,F,H4899458(+) GTAGAC/TCTGTC 2 -- ut51 ese39Minor allele frequency- T:0.00EU EA WA MN CSAM 826
    rs169903121,2
    C,F,H4785063(+) GAGCCA/GCGCCA 2 -- ut31 ese312Minor allele frequency- N:0.00NA EA EU WA 1056
    About this table

    HapMap Linkage Disequilibrium images for SLC23A2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603791

    Human Genome Epidemiology Navigator: SLC23A2 (7 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/64 PubMed articles for SLC23A2 gene (see all 64 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9962 HGNC: 10973 AceView: SLC23A2 Ensembl:ENSG00000089057 euGenes: HUgn9962
    ECgene: SLC23A2 H-InvDB: SLC23A2
    (According to HUGE)
    About This Section

    HUGE: KIAA0238
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SLC23A2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for SLC23A2 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SLC23A2 Small molecules for SLC23A2
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