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Aliases for SLC23A1 Gene

Aliases for SLC23A1 Gene

  • Solute Carrier Family 23 (Ascorbic Acid Transporter), Member 1 2 3
  • SVCT1 3 4 6
  • Solute Carrier Family 23 (Nucleobase Transporters), Member 2 2 3
  • Sodium-Dependent Vitamin C Transporter 1 3 4
  • Na(+)/L-Ascorbic Acid Transporter 1 3 4
  • Yolk Sac Permease-Like Molecule 3 3 4
  • HSVCT1 3 4
  • YSPL3 3 4
  • Solute Carrier Family 23 (Nucleobase Transporters), Member 1 3
  • Sodium-Dependent Vitamin C Transporter-1 3
  • Solute Carrier Family 23 Member 1 3
  • SLC23A2 3

External Ids for SLC23A1 Gene

Previous HGNC Symbols for SLC23A1 Gene

  • SLC23A2

Previous GeneCards Identifiers for SLC23A1 Gene

  • GC20M004823
  • GC05M138733
  • GC05M138779
  • GC05M138730
  • GC05M133892
  • GC05M138702

Summaries for SLC23A1 Gene

Entrez Gene Summary for SLC23A1 Gene

  • The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for SLC23A1 Gene

SLC23A1 (Solute Carrier Family 23 (Ascorbic Acid Transporter), Member 1) is a Protein Coding gene. Among its related pathways are Disease and PAK Pathway. GO annotations related to this gene include sodium ion transmembrane transporter activity and L-ascorbate:sodium symporter activity. An important paralog of this gene is SLC23A3.

UniProtKB/Swiss-Prot for SLC23A1 Gene

  • Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate

Gene Wiki entry for SLC23A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC23A1 Gene

Genomics for SLC23A1 Gene

Regulatory Elements for SLC23A1 Gene

Genomic Location for SLC23A1 Gene

Start:
139,367,196 bp from pter
End:
139,384,943 bp from pter
Size:
17,748 bases
Orientation:
Minus strand

Genomic View for SLC23A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC23A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC23A1 Gene

Proteins for SLC23A1 Gene

  • Protein details for SLC23A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHI7-S23A1_HUMAN
    Recommended name:
    Solute carrier family 23 member 1
    Protein Accession:
    Q9UHI7
    Secondary Accessions:
    • O95191
    • Q8WWB6
    • Q9UGH4
    • Q9UI39

    Protein attributes for SLC23A1 Gene

    Size:
    598 amino acids
    Molecular mass:
    64831 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells

    Alternative splice isoforms for SLC23A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC23A1 Gene

Proteomics data for SLC23A1 Gene at MOPED

Post-translational modifications for SLC23A1 Gene

Other Protein References for SLC23A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC23A1 Gene

Domains for SLC23A1 Gene

Gene Families for SLC23A1 Gene

Protein Domains for SLC23A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC23A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHI7

UniProtKB/Swiss-Prot:

S23A1_HUMAN :
  • Q9UHI7
Family:
  • Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
genes like me logo Genes that share domains with SLC23A1: view

Function for SLC23A1 Gene

Molecular function for SLC23A1 Gene

GENATLAS Biochemistry: solute carrier family 23,member 1 (nucleobase transport),expressed in a host of metabolically active cells and specialized tissues in the brain,eye and other organs
UniProtKB/Swiss-Prot Function: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate

Gene Ontology (GO) - Molecular Function for SLC23A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding IPI 17474147
GO:0008520 L-ascorbate:sodium symporter activity IDA 18094143
GO:0015081 sodium ion transmembrane transporter activity IDA 18094143
GO:0015205 nucleobase transmembrane transporter activity TAS 10395795
genes like me logo Genes that share ontologies with SLC23A1: view
genes like me logo Genes that share phenotypes with SLC23A1: view

Animal Models for SLC23A1 Gene

MGI Knock Outs for SLC23A1:

Animal Model Products

CRISPR Products

miRNA for SLC23A1 Gene

miRTarBase miRNAs that target SLC23A1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC23A1 Gene

Localization for SLC23A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC23A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC23A1 Gene COMPARTMENTS Subcellular localization image for SLC23A1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC23A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10395795
GO:0005903 brush border IEA --
GO:0009925 basal plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC23A1: view

Pathways for SLC23A1 Gene

SuperPathways for SLC23A1 Gene

genes like me logo Genes that share pathways with SLC23A1: view

Pathways by source for SLC23A1 Gene

Gene Ontology (GO) - Biological Process for SLC23A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9804989
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006810 transport --
GO:0006814 sodium ion transport IDA 18094143
genes like me logo Genes that share ontologies with SLC23A1: view

Compounds for SLC23A1 Gene

(2) HMDB Compounds for SLC23A1 Gene

Compound Synonyms Cas Number PubMed IDs
Ascorbic acid
  • (+)-ascorbate
50-81-7
Sodium
  • Sodium
7440-23-5

(2) Drugbank Compounds for SLC23A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin C
  • Ascorbate
50-81-7 target
Vitamin C
  • Ascorbate
50-81-7 transporter

(2) IUPHAR Ligand for SLC23A1 Gene

Ligand Type Action Affinity Pubmed IDs
[14C]ascorbic acid None None
phloretin Inhibitor Inhibition

(3) Novoseek inferred chemical compound relationships for SLC23A1 Gene

Compound -log(P) Hits PubMed IDs
dehydroascorbic acid 83.5 2
ascorbic acid 81.3 51
glucose 8.8 1
genes like me logo Genes that share compounds with SLC23A1: view

Transcripts for SLC23A1 Gene

Unigene Clusters for SLC23A1 Gene

Solute carrier family 23 (nucleobase transporters), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC23A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC23A1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - -
SP3: -
SP4: - - - -
SP5: -
SP6:

Relevant External Links for SLC23A1 Gene

GeneLoc Exon Structure for
SLC23A1
ECgene alternative splicing isoforms for
SLC23A1

Expression for SLC23A1 Gene

mRNA expression in normal human tissues for SLC23A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC23A1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (13.9), Liver (11.9), and Kidney - Cortex (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC23A1 Gene

SOURCE GeneReport for Unigene cluster for SLC23A1 Gene Hs.643467

mRNA Expression by UniProt/SwissProt for SLC23A1 Gene

Q9UHI7-S23A1_HUMAN
Tissue specificity: Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus
genes like me logo Genes that share expressions with SLC23A1: view

In Situ Assay Products

Orthologs for SLC23A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC23A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC23A1 35
  • 99.39 (n)
  • 98.84 (a)
SLC23A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC23A1 35
  • 89.77 (n)
  • 92.95 (a)
SLC23A1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC23A1 35
  • 89.58 (n)
  • 92.64 (a)
SLC23A1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc23a1 35
  • 86.73 (n)
  • 90.8 (a)
Slc23a1 16
Slc23a1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC23A1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC23A1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc23a1 35
  • 87.16 (n)
  • 91.46 (a)
chicken
(Gallus gallus)
Aves SLC23A1 35
  • 77.01 (n)
  • 80 (a)
SLC23A1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC23A1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493636 35
  • 65.53 (n)
  • 73.47 (a)
zebrafish
(Danio rerio)
Actinopterygii slc23a1 35
  • 69.65 (n)
  • 76.1 (a)
slc23a1 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6293 36
  • 43 (a)
OneToMany
CG6293 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea C51E3.6 37
  • 35 (a)
T07G12.2 37
  • 32 (a)
T07G12.5 37
  • 31 (a)
R11E3.2 37
  • 33 (a)
Y59E9AL.4 37
  • 33 (a)
T07G12.4 37
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NAT8 35
  • 43.88 (n)
  • 34.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for SLC23A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC23A1 Gene

ENSEMBL:
Gene Tree for SLC23A1 (if available)
TreeFam:
Gene Tree for SLC23A1 (if available)

Paralogs for SLC23A1 Gene

Paralogs for SLC23A1 Gene

Selected SIMAP similar genes for SLC23A1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC23A1 Gene

genes like me logo Genes that share paralogs with SLC23A1: view

Variants for SLC23A1 Gene

Sequence variations from dbSNP and Humsavar for SLC23A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4257763 -- 139,378,470(+) GGGGC(A/G)AGGCC intron-variant
rs4274973 -- 139,378,477(+) GGCCT(C/T)TCAAA intron-variant
rs6596473 -- 139,374,887(+) TCTCA(C/G)GCCCA intron-variant
rs6596474 - 139,378,270(+) CGAGG(A/C)GAAGA reference, missense
rs6596475 -- 139,383,969(+) CCGGG(C/T)CTGCA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC23A1 Gene

Variant ID Type Subtype PubMed ID
esv28262 CNV Gain 19812545

Relevant External Links for SLC23A1 Gene

HapMap Linkage Disequilibrium report
SLC23A1
Human Gene Mutation Database (HGMD)
SLC23A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC23A1 Gene

Disorders for SLC23A1 Gene

Relevant External Links for SLC23A1

Genetic Association Database (GAD)
SLC23A1
Human Genome Epidemiology (HuGE) Navigator
SLC23A1
genes like me logo Genes that share disorders with SLC23A1: view

No data available for UniProtKB/Swiss-Prot for SLC23A1 Gene

Publications for SLC23A1 Gene

  1. Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non- functional splice variant. (PMID: 10556483) Wang H. … Prasad P.D. (Biochim. Biophys. Acta 1999) 3 4 23
  2. Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. (PMID: 10556521) Daruwala R.C. … Levine M. (FEBS Lett. 1999) 3 4 23
  3. Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2). (PMID: 11584081) Erichsen H.C. … Chanock S. (J. Nutr. 2001) 3 4 23
  4. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. (PMID: 16357110) Erichsen H.C. … Chanock S.J. (Am. J. Epidemiol. 2006) 3 23 48
  5. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PMID: 18636124) Skibola C.F. … Smith M.T. (PLoS ONE 2008) 3 23 48

Products for SLC23A1 Gene

Sources for SLC23A1 Gene

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