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SLC22A8 Gene

protein-coding   GIFtS: 59
GCID: GC11M062760

Solute Carrier Family 22 (Organic Anion Transporter), Member...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22 (Organic Anion Transporter), Member 81 2
OAT32 3 5
Organic Anion Transporter 32 3
hOAT32 3
Solute Carrier Family 22 Member 82

External Ids:    HGNC: 109721   Entrez Gene: 93762   Ensembl: ENSG000001494527   OMIM: 6075815   UniProtKB: Q8TCC73   

Export aliases for SLC22A8 gene to outside databases

Previous GC identifers: GC11M065273 GC11M064335 GC11M063012 GC11M062536 GC11M062520 GC11M062516 GC11M059089


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A8 Gene:
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of
which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to
the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different
protein isoforms have been described for this gene. (provided by RefSeq, May 2010)

GeneCards Summary for SLC22A8 Gene:
SLC22A8 (solute carrier family 22 (organic anion transporter), member 8) is a protein-coding gene. GO annotations related to this gene include protein kinase C binding and organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7
Function: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions,
especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports
benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D),
p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA)

Gene Wiki entry for SLC22A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A8 gene promoter:
         CREB   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A8 promoter sequence
   Search Chromatin IP Primers for SLC22A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

SLC22A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062760:  view genomic region     (about GC identifiers)

Start:
62,756,626 bp from pter      End:
62,783,317 bp from pter
Size:
26,692 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7 (See protein sequence)
Recommended Name: Solute carrier family 22 member 8  
Size: 542 amino acids; 59856 Da
Sequence caution: Sequence=AAD19357.1; Type=Frameshift; Positions=Several; Sequence=BAD92929.1; Type=Erroneous
initiation;
Secondary accessions: B4DPH7 F5GWA8 F5H5J1 O95820 Q59EW9 Q96TC1
Alternative splicing: 5 isoforms:  Q8TCC7-1   Q8TCC7-2   Q8TCC7-5   Q8TCC7-3   Q8TCC7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC22A8: NX_Q8TCC7

Explore proteomics data for SLC22A8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC22A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001171661.1  NP_001171662.1  NP_001171665.1  NP_004245.2  

    ENSEMBL proteins: 
     ENSP00000337335   ENSP00000441658   ENSP00000443368   ENSP00000311463   ENSP00000398548  
    Reactome Protein details: Q8TCC7

    SLC22A8 Human Recombinant Protein Products:

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    Novus Biologicals SLC22A8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC22A8 

     
    antibodies-online proteins for SLC22A8 (4 products) 

     
    antibodies-online peptides for SLC22A8

    SLC22A8 Antibody Products:

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    antibodies-online antibodies for SLC22A8 (39 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic anion transporter 3
    Organic anion transporters (OATs)

    5 InterPro protein domains:
     IPR004749 Orgcat_transp
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8TCC7

    ProtoNet protein and cluster: Q8TCC7

    1 Blocks protein domain: IPB005829 Sugar transporter superfamily

    UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22A8_HUMAN, Q8TCC7
    Function: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions,
    especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports
    benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D),
    p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA)

         Genatlas biochemistry entry for SLC22A8:
    solute carrier protein family 22,member A8,polyspecific transporter for organic cations,mediating the coupled
    exchange of alpha-ketoglutarate with multiple organic ions,expressed strongly in kidney,weakly in brain

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005452inorganic anion exchanger activity IDA15037815
    GO:0008514organic anion transmembrane transporter activity IEA--
    GO:0015075ion transmembrane transporter activity ----
    GO:0015651quaternary ammonium group transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC22A8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC22A8:
     Decreased viability with cispl  Increased circadian period len 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc22a8):
     homeostasis/metabolism  renal/urinary system 

    Find genes that share phenotypes with SLC22A8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc22a8tm1Ngm for SLC22A8

       genOway: Develop your customized and physiologically relevant rodent model for SLC22A8

    miRNA
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    miRTarBase miRNAs that target SLC22A8:
    hsa-mir-26b-5p (MIRT028886)

    Block miRNA regulation of human, mouse, rat SLC22A8 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SLC22A8:
    hsa-miR-4271 hsa-miR-3117-3p hsa-miR-625 hsa-miR-3202 hsa-miR-1258 hsa-miR-1207-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC22A8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22A8_HUMAN, Q8TCC7: Basolateral cell membrane; Multi-pass membrane protein (Potential). Note=Localizes on the
    brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal
    tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells
    (BCEC) (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0016323basolateral plasma membrane IDA15037815
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLC22A8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC22A8 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Organic anion transport0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Statin Pathway - Generalized, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics0.50
    Pravastatin Pathway, Pharmacokinetics0.00
    Ibuprofen Pathway, Pharmacokinetics0.50
    3Methotrexate Pathway, Pharmacokinetics
    Methotrexate Pathway (Brain Cell), Pharmacokinetics0.43
    Methotrexate Pathway, Pharmacokinetics0.43
    4Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    5Bile secretion
    Bile secretion


    Find genes that share SuperPaths with SLC22A8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC22A8
        Organic anion transport

    Selected PharmGKB Pathways for SLC22A8 (see all 6)
        Ibuprofen Pathway, Pharmacokinetics
    Methotrexate Pathway (Brain Cell), Pharmacokinetics
    Methotrexate Pathway, Pharmacokinetics
    Pravastatin Pathway, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics

    1 Kegg Pathway  (Kegg details for SLC22A8):
        Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC22A8: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC22A8

    1 Interacting protein for SLC22A8 (Q8TCC73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCZQ055133I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009636response to toxic substance IEA--
    GO:0015697quaternary ammonium group transport ----
    GO:0031427response to methotrexate IEA--
    GO:0034220ion transmembrane transport ----
    GO:0034635glutathione transport IEA--

    Find genes that share ontologies with SLC22A8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A8 (S22A8)

    Selected DrugBank Compounds for SLC22A8 (see all 73)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Probenecid-- 57-66-9targetinhibitor10224140 12488248 11669456 11426832 12130730 10592235
    transporterinhibitor10224140 12488248 11669456 11426832 12130730 10592235 20519552 11408557 14978359 10224140 11306713 11669456 11961115 11426832 14762099 12130730 20460822 12679720
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transportersubstrate inhibitor14586168 11408557 15100168 10224140 11306713 10049739 11669456 11961115 14762099 11861777 12679720 12011098
    Cimetidine-- 51481-61-9transportersubstrate inhibitor14586168 15100168 16291876 14978359 10224140 11306713 11669456 11961115 14762099 12679720 15496291
    Penicillin G-- 61-33-6transportersubstrate inhibitor10224140 11306713 11669456 11961115 14762099 11861777 12130730 12679720
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate inhibitor15100168 10224140 11306713 11961115 14762099 12679720 12011098
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor10224140 11306713 11669456 14762099 12130730 12679720
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate inhibitor10224140 11306713 14762099 12130730 20460822
    Taurocholic Acid-- 81-24-3transportersubstrate inhibitor11408557 10224140 11306713 14762099 12011098
    Cefacetrile7-Cyanacetylamino-cephalosporansaeure (see all 4)10206-21-0transportersubstrate inhibitor15618660 11909604 12005172 10411577
    Acyclovir9-Hyroxyethoxymethylguanine (see all 8)59277-89-3transportersubstrate inhibitor11306713 11861798 12358729

    Selected Novoseek inferred chemical compound relationships for SLC22A8 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrone sulfate 86.2 5 17674156 (1), 14586168 (1), 17639024 (1), 12605306 (1)
    probenecid 81.9 2 18930752 (1), 15820748 (1)
    glutaric acid 78 2 20237588 (1), 15820748 (1)
    indoxyl sulfate 77.4 2 17264878 (1), 19837111 (1)
    benzylpenicillin 75.2 1 15846473 (1)
    cimetidine 62.8 1 16997449 (1)
    thiopurine 60.4 1 15287899 (1)
    pravastatin 58.2 3 14729100 (1), 12811365 (1)
    alpha-ketoglutarate 57.6 1 15319545 (1)
    dicarboxylate 57.5 1 15319545 (1)

    1 PharmGKB related drug/compound annotation for SLC22A8 gene    About this table
    Drug/compound PharmGKB Annotation
    dabrafenib



    Find genes that share compounds with SLC22A8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A8 gene (4 alternative transcripts): 
    NM_001184732.1  NM_001184733.1  NM_001184736.1  NM_004254.3  

    Unigene Cluster for SLC22A8:

    Solute carrier family 22 (organic anion transporter), member 8
    Hs.266223  [show with all ESTs]
    Unigene Representative Sequence: AB209692
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539841(uc001nwn.1) ENST00000336232(uc001nwp.2 uc009yom.3 uc009yon.3 uc001nwo.3 uc010rmm.2)
    ENST00000451262 ENST00000545207 ENST00000535878 ENST00000311438 ENST00000430500
    ENST00000542795 ENST00000542904 ENST00000544707
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    hsa-miR-4271 hsa-miR-3117-3p hsa-miR-625 hsa-miR-3202 hsa-miR-1258 hsa-miR-1207-5p hsa-miR-3616-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC22A8
      QuantiFast Probe-based Assays in human, mouse, rat SLC22A8

    Additional mRNA sequence: 

    AB042505.1 AB209692.1 AK123243.1 AK298351.1 AK307850.1 AK313187.1 BC022387.1 

    6 DOTS entries:

    DT.109514  DT.100742934  DT.86821046  DT.91756860  DT.99974907  DT.120760606 

    Selected AceView cDNA sequences (see all 46):

    BC022387 BM707779 BM707837 H20273 BM686171 NM_004254 BU732935 AB042505 
    CD672262 BM923908 BI762768 BX096071 BI760662 BG427793 H41333 AW025372 
    H18608 AA877205 BG427817 BG427890 AI245108 AK123243 CA392575 BG399906 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A8 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:                                -     -                       -                                               -                                       
    SP2:                                -     -                       -                                               -                                       
    SP3:                                      -                       -                                                                                       
    SP4:              -     -           -     -                       -                                                                                       
    SP5:                                                              -                                                                                       


    ECgene alternative splicing isoforms for SLC22A8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATCCAAT
    SLC22A8 Expression
    About this image


    SLC22A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Kidney (Urinary System)
    SLC22A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.266223

    UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7
    Tissue specificity: Expressed in kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC22A8: 
              Drug Transporters in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC22A8 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a81 , 5 solute carrier family 22 (organic anion transporter), more1, 5 82.18(n)1
    78.21(a)1
      19 (5.44 cM)5
    198791  NM_001164635.11  NP_001158107.11 
     85912545 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    50(a)
    50(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL344355.1(20356-33190)
    GL343672.1(16823-23266)
    zebrafish
    (Danio rerio)
    Actinopterygii slc22a6l6
    solute carrier family 22 (organic anion transporte...
    47(a)
    1 → many
    21(27873057-27888716) ENSDARG00000055523


    ENSEMBL Gene Tree for SLC22A8 (if available)
    TreeFam Gene Tree for SLC22A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A8 gene
    SLC22A112  SLC22A52  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  SLC22A132  
    SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A32  SLC22A252  
    Selected SIMAP similar genes for SLC22A8 using alignment to 2 protein entries:     S22A8_HUMAN (see all proteins) (see all similar genes):
    SLC22A6    SLC22A20    SLC22A11    HMFN2567    SLC22A12    SLC22A10
    SLC22A7    SLC22A13    OAT7    SLC22A9    SLC22A24    SLC22A25
    UST6    SLC22A5    SLC22A3    SLC22A14    SLC22A2    SLC22A4

    Find genes that share paralogs with SLC22A8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A8 (see all 531)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs588550551,2
    C,F--62759859(+) ACAGCG/AGTCAG 4 -- ds50013Minor allele frequency- A:0.27WA 122
    rs747580981,2
    C--62759942(+) CTATCA/TGCTGG 4 -- ds50010--------
    rs1880434171,2
    --62759944(+) ATCTGC/TTGGGC 4 -- ds50010--------
    rs1114363311,2
    C--62759968(+) ATAGAC/TCAGAG 4 -- ds50010--------
    rs1380528751,2
    C--62759986(+) GTGATC/GAGGGG 4 -- ds50010--------
    rs1925049601,2
    --62759993(+) GGGGAA/TAGAAA 4 -- ds50010--------
    rs1838881231,2
    --62760030(+) GTCTGC/TAGCCA 4 -- ds50010--------
    rs754740131,2
    C,F--62760038(+) CCACTC/ATGGGC 4 -- ds50013Minor allele frequency- A:0.17WA CSA 122
    rs1160778751,2
    C,F--62760063(+) GCTCAT/CATGCA 4 -- ds50012Minor allele frequency- C:0.02WA EA 238
    rs1882219471,2
    --62760112(+) CAGGCA/GTGGTG 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC22A8 (62756626 - 62783317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC22A8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34011CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607581    OMIM disorders: --


    Find genes that share disorders with SLC22A8           About GenesLikeMe

    Genetic Association Database (GAD): SLC22A8
    Human Genome Epidemiology (HuGE) Navigator: SLC22A8 (6 documents)

    Export disorders for SLC22A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A8 gene, integrated from 10 sources (see all 122):
    (articles sorted by number of sources associating them with SLC22A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PubMed id 10049739)1, 2, 3, 7 Race J.E.... Holtzman E.J. (Biochem. Biophys. Res. Commun. 1999)
    2. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. (PubMed id 16291576)1, 2, 4, 9 Erdman A.R.... Giacomini K.M. (Am. J. Physiol. 2006)
    3. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. (PubMed id 12811365)1, 2, 4, 9 Nishizato Y.... Sugiyama Y. (Clin. Pharmacol. Ther. 2003)
    4. Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. (PubMed id 14586168)1, 2, 7, 9 Bakhiya A.... Wolff N. (Cell. Physiol. Biochem. 2003)
    5. Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. (PubMed id 15846473)1, 2, 9 Tahara H.... Sugiyama Y. (Pharm. Res. 2005)
    6. Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. (PubMed id 16455804)1, 2, 9 Tahara H.... Sugiyama Y. (Drug Metab. Dispos. 2006)
    7. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    8. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    9. Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). (PubMed id 15644426)1, 2 Srimaroeng C.... Pritchard J.B. (J. Pharmacol. Exp. Ther. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9376 HGNC: 10972 AceView: SLC22A8 Ensembl:ENSG00000149452 euGenes: HUgn9376
    ECgene: SLC22A8 Kegg: 9376 H-InvDB: SLC22A8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A8 gene:
    Search GeneIP for patents involving SLC22A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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