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SLC22A8 Gene

protein-coding GIFtS: 59
GCID: GC11M062760

Solute Carrier Family 22 (Organic Anion Transporter), Member...

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Solute Carrier Family 22 (Organic Anion Transporter), Member 8¹ ²
OAT3² ³ ⁵
Organic Anion Transporter 3² ³
hOAT3² ³
Solute Carrier Family 22 Member 8²

External Ids:	HGNC: 10972¹	Entrez Gene: 9376²	Ensembl: ENSG00000149452⁷	OMIM: 607581⁵	UniProtKB: Q8TCC7³

Export aliases for SLC22A8 gene to outside databases

Previous GC identifers: GC11M065273 GC11M064335 GC11M063012 GC11M062536 GC11M062520 GC11M062516 GC11M059089

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC22A8 Gene:

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of

which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to

the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different

protein isoforms have been described for this gene. (provided by RefSeq, May 2010)

GeneCards Summary for SLC22A8 Gene:

SLC22A8 (solute carrier family 22 (organic anion transporter), member 8) is a protein-coding gene. GO annotations related to this gene include protein kinase C binding and organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7

Function: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions,

especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports

benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D),

p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA)

Gene Wiki entry for SLC22A8 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000011.9 NC_018922.2 NT_167190.2

Regulatory elements:

Regulatory transcription factor binding sites in the SLC22A8 gene promoter:
CREB deltaCREB aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC22A8 promoter sequence

Search Chromatin IP Primers for SLC22A8

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12.3

SLC22A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A8 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M062760: view genomic region (about GC identifiers)

Start:	62,756,626 bp from pter	End:	62,783,317 bp from pter
Size:	26,692 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7 (See protein sequence)

Recommended Name: Solute carrier family 22 member 8

Size: 542 amino acids; 59856 Da

Sequence caution: Sequence=AAD19357.1; Type=Frameshift; Positions=Several; Sequence=BAD92929.1; Type=Erroneous

initiation;

Secondary accessions: B4DPH7 F5GWA8 F5H5J1 O95820 Q59EW9 Q96TC1

Alternative splicing: 5 isoforms: Q8TCC7-1 Q8TCC7-2 Q8TCC7-5 Q8TCC7-3 Q8TCC7-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC22A8: NX_Q8TCC7

Explore proteomics data for SLC22A8 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SLC22A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001171661.1 NP_001171662.1 NP_001171665.1 NP_004245.2

ENSEMBL proteins:

ENSP00000337335 ENSP00000441658 ENSP00000443368 ENSP00000311463 ENSP00000398548

Reactome Protein details: Q8TCC7

SLC22A8 Human Recombinant Protein Products:

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	Novus Biologicals SLC22A8 Proteins Novus Biologicals SLC22A8 Lysates
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	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for SLC22A8
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	antibodies-online proteins for SLC22A8 (4 products)
	antibodies-online peptides for SLC22A8

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	antibodies-online antibodies for SLC22A8 (39 products)

SLC22A8 Assay Products:

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	antibodies-online kits for SLC22A8 (11 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Organic anion transporter 3

Organic anion transporters (OATs)

5 InterPro protein domains:

IPR004749 Orgcat_transp

IPR005829 Sugar_transporter_CS

IPR005828 Sub_transporter

IPR020846 MFS_dom

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q8TCC7

ProtoNet protein and cluster: Q8TCC7

1 Blocks protein domain: IPB005829 Sugar transporter superfamily

UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7

Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)

family

Find genes that share domains with SLC22A8 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S22A8_HUMAN, Q8TCC7

Function: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions,

especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports

benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D),

p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA)

Genatlas biochemistry entry for SLC22A8:

solute carrier protein family 22,member A8,polyspecific transporter for organic cations,mediating the coupled

exchange of alpha-ketoglutarate with multiple organic ions,expressed strongly in kidney,weakly in brain

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005080	protein kinase C binding	IEA	--
GO:0005452	inorganic anion exchanger activity	IDA	15037815
GO:0008514	organic anion transmembrane transporter activity	IEA	--
GO:0015075	ion transmembrane transporter activity	--	--
GO:0015651	quaternary ammonium group transmembrane transporter activity	IEA	--

Find genes that share ontologies with SLC22A8 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for SLC22A8:

Decreased viability with cispl

Increased circadian period len

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc22a8):

homeostasis/metabolism

renal/urinary system

Find genes that share phenotypes with SLC22A8 About GenesLikeMe

Animal Models:
MGI mouse knock-out Slc22a8^tm1Ngm for SLC22A8

genOway: Develop your customized and physiologically relevant rodent model for SLC22A8

miRNA Products:		miRTarBase miRNAs that target SLC22A8: hsa-mir-26b-5p (MIRT028886)

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		7 qRT-PCR Assays for microRNAs that regulate SLC22A8:
		hsa-miR-4271 hsa-miR-3117-3p hsa-miR-625 hsa-miR-3202 hsa-miR-1258 hsa-miR-1207-5p hsa-miR-3616-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SLC22A8 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SLC22A8
		Predesigned siRNA for gene silencing in human, mouse, rat SLC22A8

Gene Editing
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DNA2.0 Custom Protein Engineering Service for SLC22A8

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A8

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

S22A8_HUMAN, Q8TCC7: Basolateral cell membrane; Multi-pass membrane protein (Potential). Note=Localizes on the

brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal

tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells

(BCEC) (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
cytosol	1
golgi apparatus	1
nucleus	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral component of membrane	IEA	--
GO:0016323	basolateral plasma membrane	IDA	15037815
GO:0070062	extracellular vesicular exosome	IDA	19056867

Find genes that share ontologies with SLC22A8 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for SLC22A8 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

SLC-mediated transmembrane transport	0.47	Organic anion transport	0.00
Transmembrane transport of small molecules	0.47	Organic cation/anion/zwitterion transport	0.00
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38

Statin Pathway - Generalized, Pharmacokinetics

	Statin Pathway - Generalized, Pharmacokinetics	0.50			Pravastatin Pathway, Pharmacokinetics	0.00
	Ibuprofen Pathway, Pharmacokinetics	0.50

Methotrexate Pathway, Pharmacokinetics

Methotrexate Pathway (Brain Cell), Pharmacokinetics

0.43

Methotrexate Pathway, Pharmacokinetics

0.43

Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

Bile secretion

Bile secretion

Find genes that share SuperPaths with SLC22A8 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for SLC22A8

Organic anion transport

Selected PharmGKB Pathways for SLC22A8 (see all 6)

	Ibuprofen Pathway, Pharmacokinetics
	Methotrexate Pathway (Brain Cell), Pharmacokinetics
	Methotrexate Pathway, Pharmacokinetics
	Pravastatin Pathway, Pharmacokinetics
	Statin Pathway - Generalized, Pharmacokinetics

1 Kegg Pathway (Kegg details for SLC22A8):

Bile secretion

Pathway & Disease-focused RT² Profiler PCR Array including SLC22A8:

Drug Transporters in human mouse rat

Interactions:

GeneGlobe Interaction Network for SLC22A8

1 Interacting protein for SLC22A8 (Q8TCC7³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKCZ	Q05513³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009636	response to toxic substance	IEA	--
GO:0015697	quaternary ammonium group transport	--	--
GO:0031427	response to methotrexate	IEA	--
GO:0034220	ion transmembrane transport	--	--
GO:0034635	glutathione transport	IEA	--

Find genes that share ontologies with SLC22A8 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SLC22A8 (S22A8)

Selected DrugBank Compounds for SLC22A8 (see all 73) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Probenecid	--	57-66-9	target	inhibitor	10224140 12488248 11669456 11426832 12130730 10592235
Probenecid	--	57-66-9	transporter	inhibitor	10224140 12488248 11669456 11426832 12130730 10592235 20519552 11408557 14978359 10224140 11306713 11669456 11961115 11426832 14762099 12130730 20460822 12679720
Aminohippurate	Aminohippurate Sodium (see all 7)	94-16-6	transporter	substrate inhibitor	14586168 11408557 15100168 10224140 11306713 10049739 11669456 11961115 14762099 11861777 12679720 12011098
Cimetidine	--	51481-61-9	transporter	substrate inhibitor	14586168 15100168 16291876 14978359 10224140 11306713 11669456 11961115 14762099 12679720 15496291
Penicillin G	--	61-33-6	transporter	substrate inhibitor	10224140 11306713 11669456 11961115 14762099 11861777 12130730 12679720
Conjugated Estrogens	Estrogens (see all 10)	438-67-5	transporter	substrate inhibitor	15100168 10224140 11306713 11961115 14762099 12679720 12011098
Indomethacin	IMN (see all 9)	53-86-1	transporter	inhibitor	10224140 11306713 11669456 14762099 12130730 12679720
Methotrexate	Amethopterin (see all 12)	59-05-2	transporter	substrate inhibitor	10224140 11306713 14762099 12130730 20460822
Taurocholic Acid	--	81-24-3	transporter	substrate inhibitor	11408557 10224140 11306713 14762099 12011098
Cefacetrile	7-Cyanacetylamino-cephalosporansaeure (see all 4)	10206-21-0	transporter	substrate inhibitor	15618660 11909604 12005172 10411577
Acyclovir	9-Hyroxyethoxymethylguanine (see all 8)	59277-89-3	transporter	substrate inhibitor	11306713 11861798 12358729

Selected Novoseek inferred chemical compound relationships for SLC22A8 gene (see all 16) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrone sulfate	86.2	5	17674156 (1), 14586168 (1), 17639024 (1), 12605306 (1)
probenecid	81.9	2	18930752 (1), 15820748 (1)
glutaric acid	78	2	20237588 (1), 15820748 (1)
indoxyl sulfate	77.4	2	17264878 (1), 19837111 (1)
benzylpenicillin	75.2	1	15846473 (1)
cimetidine	62.8	1	16997449 (1)
thiopurine	60.4	1	15287899 (1)
pravastatin	58.2	3	14729100 (1), 12811365 (1)
alpha-ketoglutarate	57.6	1	15319545 (1)
dicarboxylate	57.5	1	15319545 (1)

1 PharmGKB related drug/compound annotation for SLC22A8 gene About this table

Drug/compound	PharmGKB Annotation
dabrafenib

Find genes that share compounds with SLC22A8 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for SLC22A8 gene (4 alternative transcripts):

NM_001184732.1 NM_001184733.1 NM_001184736.1 NM_004254.3

Unigene Cluster for SLC22A8:

Solute carrier family 22 (organic anion transporter), member 8

Hs.266223 [show with all ESTs]

Unigene Representative Sequence: AB209692

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000539841(uc001nwn.1) ENST00000336232(uc001nwp.2 uc009yom.3 uc009yon.3 uc001nwo.3 uc010rmm.2)

ENST00000451262 ENST00000545207 ENST00000535878 ENST00000311438 ENST00000430500

ENST00000542795 ENST00000542904 ENST00000544707

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		7 qRT-PCR Assays for microRNAs that regulate SLC22A8:
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		SwitchGear 3'UTR luciferase reporter plasmid: SLC22A8 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat SLC22A8

Clone Products:		OriGene clones in human, mouse for SLC22A8 (see all 17) OriGene ORF clones in mouse, rat for SLC22A8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SLC22A8 (NM_004254)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A8

Primer Products:		OriGene qPCR primer pairs and template standards for SLC22A8 OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A8
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SLC22A8
		QuantiTect SYBR Green Assays in human, mouse, rat SLC22A8
		QuantiFast Probe-based Assays in human, mouse, rat SLC22A8

Additional mRNA sequence:

AB042505.1 AB209692.1 AK123243.1 AK298351.1 AK307850.1 AK313187.1 BC022387.1

6 DOTS entries:

DT.109514 DT.100742934 DT.86821046 DT.91756860 DT.99974907 DT.120760606

Selected AceView cDNA sequences (see all 46):

BC022387 BM707779 BM707837 H20273 BM686171 NM_004254 BU732935 AB042505

CD672262 BM923908 BI762768 BX096071 BI760662 BG427793 H41333 AW025372

H18608 AA877205 BG427817 BG427890 AI245108 AK123243 CA392575 BG399906

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A8 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c
SP1:											-		-								-																-
SP2:											-		-								-																-
SP3:													-								-
SP4:					-		-				-		-								-
SP5:																					-

ECgene alternative splicing isoforms for SLC22A8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC22A8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGATCCAAT

About this image

SLC22A8 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Brain (Nervous System) fully expand to see all 7 entries
Mature Choroid Plexus Cells Choroid Plexus
Cerebral Cortex

Neural Tube (Nervous System) fully expand to see all 4 entries
Metencephalon

Epithelial Cells
Mature Choroid Plexus Cells Choroid Plexus

Endothelium (Cardiovascular System)
Endothelial Cells Blood Brain Barrier

Kidney (Urinary System)

SLC22A8 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SLC22A8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.266223

UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7

Tissue specificity: Expressed in kidney

Pathway & Disease-focused RT² Profiler PCR Array including SLC22A8:

Drug Transporters in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for SLC22A8 OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A8
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A8 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slc22a8^{1 , 5}	solute carrier family 22 (organic anion transporter), more^{1, 5}	82.18(n)¹ 78.21(a)¹		19 (5.44 cM)⁵ 19879¹ NM_001164635.1¹ NP_001158107.1¹ 8591254⁵
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	Uncharacterized protein (see all 4)	50(a) 50(a) (see all 4)	many ↔ many many ↔ many (see all 4)	GL344355.1(20356-33190) GL343672.1(16823-23266)
zebrafish (Danio rerio)	Actinopterygii	slc22a6l⁶	solute carrier family 22 (organic anion transporte...	47(a)	1 → many	21(27873057-27888716) ENSDARG00000055523

ENSEMBL Gene Tree for SLC22A8 (if available)
TreeFam Gene Tree for SLC22A8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for SLC22A8 gene

SLC22A11² SLC22A5² SLC22A1² SLC22A24² SLC22A4² SLC22A2² SLC22A10² SLC22A13²

SLC22A9² SLC22A6² SLC22A15² SLC22A12² SLC22A7² SLC22A16² SLC22A3² SLC22A25²

Selected SIMAP similar genes for SLC22A8 using alignment to 2 protein entries: S22A8_HUMAN (see all proteins) (see all similar genes):

SLC22A6 SLC22A20 SLC22A11 HMFN2567 SLC22A12 SLC22A10

SLC22A7 SLC22A13 OAT7 SLC22A9 SLC22A24 SLC22A25

UST6 SLC22A5 SLC22A3 SLC22A14 SLC22A2 SLC22A4

Find genes that share paralogs with SLC22A8 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58855055^1,2	C,F	--	62759859(+)	`ACAGCG/AGTCAG`	4	--	ds500¹		3		WA	122
rs74758098^1,2	C	--	62759942(+)	`CTATCA/TGCTGG`	4	--	ds500¹		0	--	--	--	--
rs188043417^1,2		--	62759944(+)	`ATCTGC/TTGGGC`	4	--	ds500¹		0	--	--	--	--
rs111436331^1,2	C	--	62759968(+)	`ATAGAC/TCAGAG`	4	--	ds500¹		0	--	--	--	--
rs138052875^1,2	C	--	62759986(+)	`GTGATC/GAGGGG`	4	--	ds500¹		0	--	--	--	--
rs192504960^1,2		--	62759993(+)	`GGGGAA/TAGAAA`	4	--	ds500¹		0	--	--	--	--
rs183888123^1,2		--	62760030(+)	`GTCTGC/TAGCCA`	4	--	ds500¹		0	--	--	--	--
rs75474013^1,2	C,F	--	62760038(+)	`CCACTC/ATGGGC`	4	--	ds500¹		3		WA CSA	122
rs116077875^1,2	C,F	--	62760063(+)	`GCTCAT/CATGCA`	4	--	ds500¹		2		WA EA	238
rs188221947^1,2		--	62760112(+)	`CAGGCA/GTGGTG`	4	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC22A8 (62756626 - 62783317 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for SLC22A8: About this table

Variant ID	Type	Subtype	PubMed ID
esv34011	CNV	Loss	18971310

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 607581 OMIM disorders: --

Find genes that share disorders with SLC22A8 About GenesLikeMe

Genetic Association Database (GAD): SLC22A8
Human Genome Epidemiology (HuGE) Navigator: SLC22A8 (6 documents)

Export disorders for SLC22A8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC22A8 gene, integrated from 10 sources (see all 122):
(articles sorted by number of sources associating them with SLC22A8)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PubMed id 10049739)^{1, 2, 3, 7} Race J.E.... Holtzman E.J. (Biochem. Biophys. Res. Commun. 1999)
The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. (PubMed id 16291576)^{1, 2, 4, 9} Erdman A.R.... Giacomini K.M. (Am. J. Physiol. 2006)
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. (PubMed id 12811365)^{1, 2, 4, 9} Nishizato Y.... Sugiyama Y. (Clin. Pharmacol. Ther. 2003)
Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. (PubMed id 14586168)^{1, 2, 7, 9} Bakhiya A.... Wolff N. (Cell. Physiol. Biochem. 2003)
Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. (PubMed id 15846473)^{1, 2, 9} Tahara H.... Sugiyama Y. (Pharm. Res. 2005)
Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. (PubMed id 16455804)^{1, 2, 9} Tahara H.... Sugiyama Y. (Drug Metab. Dispos. 2006)
Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)^{1, 4} Holmes M.V....Casas J.P. (PLoS ONE 2009)
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)^{1, 4} Saito A....Kamatani N. (J. Hum. Genet. 2009)
Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). (PubMed id 15644426)^{1, 2} Srimaroeng C.... Pritchard J.B. (J. Pharmacol. Exp. Ther. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9376	HGNC: 10972	AceView: SLC22A8	Ensembl:ENSG00000149452	euGenes: HUgn9376
ECgene: SLC22A8	Kegg: 9376	H-InvDB: SLC22A8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC22A8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC22A8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC22A8 gene:
Search GeneIP for patents involving SLC22A8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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SLC22A8 Gene

Solute Carrier Family 22 (Organic Anion Transporter), Member...

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SLC22A8 Gene

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