Aliases for SLC22A8 Gene
Aliases for SLC22A8 Gene
External Ids for SLC22A8 Gene
- HGNC: 10972
- Entrez Gene: 9376
- Ensembl: ENSG00000149452
- OMIM: 607581
- UniProtKB: Q8TCC7
Previous GeneCards Identifiers for SLC22A8 Gene
- GC11M065273
- GC11M064335
- GC11M062536
- GC11M062520
- GC11M062516
- GC11M062760
- GC11M059089
Summaries for SLC22A8 Gene
-
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
GeneCards Summary for SLC22A8 Gene
SLC22A8 (Solute Carrier Family 22 Member 8) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Methotrexate Pathway, Pharmacokinetics. GO annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A6.
UniProtKB/Swiss-Prot for SLC22A8 Gene
-
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A8 Gene
Genomics for SLC22A8 Gene
Regulatory Elements for SLC22A8 Gene
Enhancers for SLC22A8 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G063245 | 0.9 | dbSUPER | 10.6 | -231.7 | -231695 | 3.3 | TBP FOXA2 ZBTB40 RARA YY1 GATA2 CREM MIXL1 SP5 CEBPA | SLC22A8 SLC22A9 SLC22A25 LOC105369334 |
| GH11G062896 | 0.5 | dbSUPER | 11 | +119.4 | 119390 | 0.6 | EGR1 CHD1 ZBTB33 ZNF384 NR2F2 | SLC22A8 BSCL2 ROM1 GC11P062886 ENSG00000257002 |
| GH11G062895 | 0.4 | dbSUPER | 11 | +120.3 | 120305 | 0.5 | GLIS1 | SLC22A8 GC11P062886 ENSG00000257002 |
| GH11G063020 | 0.8 | ENCODE | 0.7 | -5.0 | -4989 | 0.2 | HDGF BCOR CTCF KLF1 RB1 ZNF239 SMC3 KLF13 ZBTB20 SMARCA5 | SLC22A8 LOC100127954 |
| GH11G063023 | 1.3 | Ensembl ENCODE | 0.4 | -8.3 | -8344 | 1.1 | HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 | COX8A LOC100127954 SLC22A8 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SLC22A8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SLC22A8 gene promoter:
Regulatory Element Products
Genomic Location for SLC22A8 Gene
- Chromosome:
- 11
- Start:
- 62,989,154 bp from pter
- End:
- 63,015,845 bp from pter
- Size:
- 26,692 bases
- Orientation:
- Minus strand
Genomic View for SLC22A8 Gene
Genes around SLC22A8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by Ensembl
- 11q12.3 by Entrez Gene
- 11q12.3 by HGNC
SLC22A8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC22A8 Gene
Proteins for SLC22A8 Gene
-
Protein details for SLC22A8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TCC7-S22A8_HUMAN
- Recommended name:
- Solute carrier family 22 member 8
- Protein Accession:
- Q8TCC7
- B4DPH7
- F5GWA8
- F5H5J1
- O95820
- Q59EW9
- Q96TC1
Protein attributes for SLC22A8 Gene
- Size:
- 542 amino acids
- Molecular mass:
- 59856 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD19357.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD92929.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SLC22A8 Gene
Post-translational modifications for SLC22A8 Gene
Other Protein References for SLC22A8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SLC22A8
- Invitrogen Antibodies for SLC22A8
- antibodies-online Antibodies for SLC22A8: See all 53
- GeneTex SLC22A8 antibody for SLC22A8
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC22A8
Protein Products
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Assay Products
- antibodies-online Kits for SLC22A8: See all 3
No data available for DME Specific Peptides for SLC22A8 Gene
Domains & Families for SLC22A8 Gene
Gene Families for SLC22A8 Gene
- HGNC:
- IUPHAR :
Protein Domains for SLC22A8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC22A8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TCC7UniProtKB/Swiss-Prot:
S22A8_HUMAN :- Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
- Family:
-
- Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Function for SLC22A8 Gene
Molecular function for SLC22A8 Gene
- GENATLAS Biochemistry:
- solute carrier protein family 22,member A8,polyspecific transporter for organic cations,mediating the coupled exchange of alpha-ketoglutarate with multiple organic ions,expressed strongly in kidney,weakly in brain
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005452 | inorganic anion exchanger activity | IDA | 15037815 |
| GO:0015301 | anion:anion antiporter activity | TAS | -- |
| GO:0015347 | sodium-independent organic anion transmembrane transporter activity | IBA | -- |
| GO:0022857 | transmembrane transporter activity | IEA | -- |
Phenotypes for SLC22A8 Gene
- MGI mutant phenotypes for SLC22A8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SLC22A8:
Animal Model Products
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-
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ViGene Biosciences lentiviral particle packaged cDNA for SLC22A8 gene
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- Search ViGene Biosciences for SLC22A8
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miRNA for SLC22A8 Gene
- miRTarBase miRNAs that target SLC22A8
miRNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SLC22A8
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC22A8 gene
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A8 Gene
Localization for SLC22A8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC22A8 Gene
- Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016323 | basolateral plasma membrane | IDA,IEA | 15037815 |
Pathways & Interactions for SLC22A8 Gene
Pathways by source for SLC22A8 Gene
5 Reactome pathways for SLC22A8 Gene
1 KEGG pathway for SLC22A8 Gene
2 R&D Systems pathways for SLC22A8 Gene
Interacting Proteins for SLC22A8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0009636 | response to toxic substance | IEA | -- |
| GO:0015698 | inorganic anion transport | IEA | -- |
| GO:0043252 | sodium-independent organic anion transport | IBA | -- |
No data available for SIGNOR curated interactions for SLC22A8 Gene
Drugs & Compounds for SLC22A8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Probenecid | Approved | Pharma | Inhibition, Inhibitor, blocker, Target, Transporter, inhibitor | 29 | ||
| Cefotaxime | Approved | Pharma | Target, Transporter, inhibitor | 36 | ||
| Dabrafenib | Approved | Pharma | Transporter, inhibitor | BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase | 84 | |
| Cimetidine | Approved | Pharma | Inhibition, Inhibitor, Transporter, substrate, inhibitor | H2 receptor antagonist, H2 antagonist, I1 agonist | 75 | |
| Methotrexate | Approved | Pharma | Transporter, substrate, inhibitor | Folate antagonist,inhibits DFHR | 1551 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for SLC22A8 Gene
mRNA/cDNA for SLC22A8 Gene
- (5) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC22A8 Gene
CRISPR Products
-
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-
Applied Biological Materials CRISPR for SLC22A8
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC22A8
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miRNA Products
- Search ViGene Biosciences for SLC22A8
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for SLC22A8
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-
ViGene Biosciences ready-to-package AAV shRNAs for SLC22A8 gene
Clone Products
- Sino Biological Human cDNA Clone for SLC22A8
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- VectorBuilder custom plasmid, inducible vectors for SLC22A8
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for SLC22A8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Endothelial Cells Blood Brain Barrier
- Cerebellum
- Medulla Oblongata
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
-
Spinal Cord (Nervous System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for SLC22A8 Gene
This gene is overexpressed in Kidney - Cortex (x51.3).
This gene is overexpressed in Kidney (42.5), Urine (13.2), and Heart (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A8 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC22A8 Gene:
SLC22A8SOURCE GeneReport for Unigene cluster for SLC22A8 Gene:
Hs.266223mRNA Expression by UniProt/SwissProt for SLC22A8 Gene:
Q8TCC7-S22A8_HUMAN
Tissue specificity:
Expressed in kidney.
Evidence on tissue expression from TISSUES for SLC22A8 Gene
- Kidney(4.9)
- Nervous system(4.4)
- Blood(2.2)
- Urine(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for SLC22A8
-
OriGene qPCR primer pairs for SLC22A8
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A8 Gene
Orthologs for SLC22A8 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC22A8 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC22A8 34 |
|
||
| OAT3 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SLC22A8 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc22a8 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc22a8 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC22A8 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | slc22a6l 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MPH3 37 |
|
|
- Species where no ortholog for SLC22A8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SLC22A8 Gene
Paralogs for SLC22A8 Gene
(21) SIMAP similar genes for SLC22A8 Gene using alignment to 2 proteins:
Variants for SLC22A8 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000192624 | -- | 63,005,576(+) | TATAA(C/T)ATGAG | intron-variant | |
| rs1000234719 | -- | 63,017,156(+) | ATCAC(C/T)GGAAC | upstream-variant-2KB | |
| rs1000242749 | -- | 63,010,530(+) | TGAAC(A/C)ACAAA | intron-variant | |
| rs1000358390 | -- | 63,010,288(+) | ACGAT(C/T)CCACA | intron-variant | |
| rs1000396503 | -- | 63,010,800(+) | ACTGG(C/T)TCAAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv204e214 | CNV | gain | 21293372 |
| esv34011 | CNV | loss | 18971310 |
Residual Variation Intolerance Score:
49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.60;
56.35% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SLC22A8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC22A8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A8 Gene
Disorders for SLC22A8 Gene
Relevant External Links for SLC22A8
No disorders were found for SLC22A8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A8 Gene
Publications for SLC22A8 Gene
- The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. (PMID: 16291576) Erdman A.R. … Giacomini K.M. (Am. J. Physiol. 2006) 3 4 22 46 64
- Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. (PMID: 12811365) Nishizato Y. … Sugiyama Y. (Clin. Pharmacol. Ther. 2003) 3 4 22 46 64
- Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. (PMID: 16455804) Tahara H. … Sugiyama Y. (Drug Metab. Dispos. 2006) 3 4 22 64
- Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. (PMID: 15846473) Tahara H. … Sugiyama Y. (Pharm. Res. 2005) 3 4 22 64
- Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. (PMID: 14586168) Bakhiya A. … Wolff N. (Cell. Physiol. Biochem. 2003) 3 4 22 64
Products for SLC22A8 Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for SLC22A8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC22A8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC22A8 gene
- Search ViGene Biosciences for SLC22A8
- Santa Cruz Biotechnology (SCBT) Antibodies for SLC22A8
- Search Santa Cruz Biotechnology (SCBT) for SLC22A8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SLC22A8
- Horizon Cell Lines for SLC22A8
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC22A8
- VectorBuilder custom plasmid, inducible vectors for SLC22A8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC22A8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SLC22A8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio