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SLC22A8 Gene(Protein Coding)

Solute Carrier Family 22 Member 8

GCID:
GC11M063012
GIFtS:
60
Genes Participants
UDN Logo

Aliases for SLC22A8 Gene

Aliases for SLC22A8 Gene

  • Solute Carrier Family 22 Member 8 2 3
  • Solute Carrier Family 22 (Organic Anion Transporter), Member 8 2 3 5
  • Organic Anion Transporter 3 3 4
  • HOAT3 3 4
  • OAT3 3 4

External Ids for SLC22A8 Gene

Previous GeneCards Identifiers for SLC22A8 Gene

  • GC11M065273
  • GC11M064335
  • GC11M062536
  • GC11M062520
  • GC11M062516
  • GC11M062760
  • GC11M059089

Summaries for SLC22A8 Gene

Entrez Gene Summary for SLC22A8 Gene

  • This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for SLC22A8 Gene

SLC22A8 (Solute Carrier Family 22 Member 8) is a Protein Coding gene. Among its related pathways are Uricosurics Pathway, Pharmacodynamics and Statin Pathway - Generalized, Pharmacokinetics. GO annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A8 Gene

  • Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).

Gene Wiki entry for SLC22A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A8 Gene

Genomics for SLC22A8 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SLC22A8 Gene

Enhancers for SLC22A8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC22A8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SLC22A8 gene promoter:

Genomic Location for SLC22A8 Gene

Chromosome:
11
Start:
62,989,154 bp from pter
End:
63,015,845 bp from pter
Size:
26,692 bases
Orientation:
Minus strand

Genomic View for SLC22A8 Gene

Genes around SLC22A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLC22A8 Gene

Proteins for SLC22A8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SLC22A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCC7-S22A8_HUMAN
    Recommended name:
    Solute carrier family 22 member 8
    Protein Accession:
    Q8TCC7
    Secondary Accessions:
    • B4DPH7
    • F5GWA8
    • F5H5J1
    • O95820
    • Q59EW9
    • Q96TC1

    Protein attributes for SLC22A8 Gene

    Size:
    542 amino acids
    Molecular mass:
    59856 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD19357.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD92929.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A8 Gene

Proteomics data for SLC22A8 Gene at MOPED

Protein Expression for SLC22A8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SLC22A8 Gene

  • Glycosylation at Asn 86 and Asn 102
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A8 Gene

Domains & Families for SLC22A8 Gene

Gene Families for SLC22A8 Gene

HGNC:
IUPHAR :

Protein Domains for SLC22A8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCC7

UniProtKB/Swiss-Prot:

S22A8_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A8: view

Function for SLC22A8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SLC22A8 Gene

GENATLAS Biochemistry:
solute carrier protein family 22,member A8,polyspecific transporter for organic cations,mediating the coupled exchange of alpha-ketoglutarate with multiple organic ions,expressed strongly in kidney,weakly in brain
UniProtKB/Swiss-Prot Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).

Phenotypes for SLC22A8 Gene

MGI mutant phenotypes for SLC22A8:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLC22A8:
genes like me logo Genes that share phenotypes with SLC22A8: view

Animal Models for SLC22A8 Gene

MGI Knock Outs for SLC22A8:

Animal Model Products

CRISPR Products

miRNA for SLC22A8 Gene

miRTarBase miRNAs that target SLC22A8

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A8 Gene

Localization for SLC22A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A8 Gene

Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A8 Gene COMPARTMENTS Subcellular localization image for SLC22A8 gene
Compartment Confidence
extracellular 5
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for SLC22A8 Gene

Pathways & Interactions for SLC22A8 Gene

genes like me logo Genes that share pathways with SLC22A8: view

Interacting Proteins for SLC22A8 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000337335%0d%0a9606.ENSP00000269321%0d%0a9606.ENSP00000219409%0d%0a9606.ENSP00000228945%0d%0a9606.ENSP00000356436%0d%0a9606.ENSP00000363250%0d%0a
Selected Interacting proteins: ENSP00000337335 Q8TCC7-S22A8_HUMAN for SLC22A8 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC22A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043252 sodium-independent organic anion transport IBA --
genes like me logo Genes that share ontologies with SLC22A8: view

No data available for SIGNOR curated interactions for SLC22A8 Gene

Drugs & Compounds for SLC22A8 Gene

Products:

  1. Drug

(79) Drugs for SLC22A8 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved Pharma Inhibition, Inhibitor, blocker, Target, Transporter, inhibitor 27
Cefotaxime Approved Pharma Target, Transporter, inhibitor 34
Dabrafenib Approved Pharma Transporter, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 70
Cimetidine Approved Pharma Inhibition, Inhibitor, Transporter, substrate, inhibitor H2 receptor antagonist, H2 antagonist, I1 agonist 68
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR, Cytotoxic agent 1466

(7) Additional Compounds for SLC22A8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC22A8: view

Transcripts for SLC22A8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SLC22A8 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A8 Gene

Solute carrier family 22 (organic anion transporter), member 8:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6: - - -
SP7: - - - - - -
SP8:
SP9:

Relevant External Links for SLC22A8 Gene

GeneLoc Exon Structure for
SLC22A8
ECgene alternative splicing isoforms for
SLC22A8

Expression for SLC22A8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SLC22A8 Gene

mRNA expression in normal human tissues for SLC22A8 Gene
mRNA expression by BioGPS for SLC22A8 GenemRNA expression by GTEx for SLC22A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A8 Gene

This gene is overexpressed in Kidney - Cortex (x51.3).

Protein differential expression in normal tissues from HIPED for SLC22A8 Gene

This gene is overexpressed in Kidney (42.5), Urine (13.2), and Heart (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A8 Gene



SOURCE GeneReport for Unigene cluster for SLC22A8 Gene Hs.266223

mRNA Expression by UniProt/SwissProt for SLC22A8 Gene

Q8TCC7-S22A8_HUMAN
Tissue specificity: Expressed in kidney.
genes like me logo Genes that share expression patterns with SLC22A8: view

Protein tissue co-expression partners for SLC22A8 Gene

Primer Products

Orthologs for SLC22A8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC22A8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SLC22A8 35
  • 85.24 (n)
  • 81.92 (a)
OAT3 36
  • 82 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SLC22A8 35
  • 85.01 (n)
  • 78.62 (a)
SLC22A8 36
  • 70 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Slc22a8 35
  • 82.18 (n)
  • 78.21 (a)
Slc22a8 16
Slc22a8 36
  • 78 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SLC22A8 35
  • 95.28 (n)
  • 94.39 (a)
SLC22A8 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Slc22a8 35
  • 83.02 (n)
  • 79.66 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 39 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia SLC22A8 36
  • 62 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 49 (a)
 ManyToMany
-- 36
  • 50 (a)
 ManyToMany
-- 36
  • 46 (a)
 ManyToMany
-- 36
  • 50 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii slc22a6l 36
  • 47 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MPH3 38
Species with no ortholog for SLC22A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A8 Gene

ENSEMBL:
Gene Tree for SLC22A8 (if available)
TreeFam:
Gene Tree for SLC22A8 (if available)

Paralogs for SLC22A8 Gene

Paralogs for SLC22A8 Gene

(21) SIMAP similar genes for SLC22A8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC22A8: view

Variants for SLC22A8 Gene

Sequence variations from dbSNP and Humsavar for SLC22A8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11568479 - 63,000,770(-) ATCTT(A/C)ATGGC reference, missense
rs45566039 - 62,999,835(-) TTGGC(A/C/T)GCAGG reference, missense
rs11568493 - 62,996,135(-) GTCCA(G/T)ACGCT reference, missense
rs11568492 - 62,996,085(-) TACTC(C/T)GGCGG reference, missense
rs45438191 - 62,996,072(+) TGAAG(A/G)CAGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC22A8 Gene

Variant ID Type Subtype PubMed ID
esv34011 CNV Loss 18971310

Variation tolerance for SLC22A8 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC22A8 Gene

Disorders for SLC22A8 Gene

Relevant External Links for SLC22A8

Genetic Association Database (GAD)
SLC22A8
Human Genome Epidemiology (HuGE) Navigator
SLC22A8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A8

No disorders were found for SLC22A8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A8 Gene

Publications for SLC22A8 Gene

  1. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. (PMID: 16291576) Erdman A.R. … Giacomini K.M. (Am. J. Physiol. 2006) 3 4 23 48 67
  2. Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. (PMID: 14586168) Bakhiya A. … Wolff N. (Cell. Physiol. Biochem. 2003) 3 23 25
  3. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PMID: 10049739) Race J.E. … Holtzman E.J. (Biochem. Biophys. Res. Commun. 1999) 2 3 25
  4. Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS). (PMID: 20237588) RAPdiger M. … Bahn A. (Can. J. Physiol. Pharmacol. 2010) 3 23
  5. Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). (PMID: 19029202) Ose A. … Sugiyama Y. (Drug Metab. Dispos. 2009) 23 25

Products for SLC22A8 Gene

Sources for SLC22A8 Gene

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