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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC22A8 Gene

protein-coding   GIFtS: 59
GCID: GC11M062760

solute carrier family 22 (organic anion transporter), member...
 Explore 8 diseases affiliated with
SLC22A8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC22A8    

Aliases
for SLC22A8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 22 (Organic Anion Transporter), Member 81 2
OAT31 2 3 5
Organic Anion Transporter 32 3
HOAT31
Solute Carrier Family 22 Member 82

External Ids:    HGNC: 109721   Entrez Gene: 93762   Ensembl: ENSG000001494527   OMIM: 6075815   UniProtKB: Q8TCC73   

Export aliases for SLC22A8 gene to outside databases

Previous GC identifers: GC11M065273 GC11M064335 GC11M063012 GC11M062536 GC11M062520 GC11M062516 GC11M059089


Summaries
for SLC22A8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC22A8:
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which
are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the
basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein
isoforms have been described for this gene. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7
Function: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions,
especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports
benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D),
p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA)

Gene Wiki entry for SLC22A8


Genomic Views
for SLC22A8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC22A8 gene promoter:
         CREB   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC22A8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC22A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

SLC22A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062760:  view genomic region     (about GC identifiers)

Start:
 62,756,626 bp from pter      End:
 62,783,317 bp from pter
Size:
 26,692 bases      Orientation:
 minus strand

Proteins
for SLC22A8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7 (See protein sequence)
Recommended Name: Solute carrier family 22 member 8  
Size: 542 amino acids; 59856 Da
Subcellular location: Basolateral cell membrane; Multi-pass membrane protein (Potential). Note=Localizes on the brush
border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells.
Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By
similarity)
Sequence caution: Sequence=AAD19357.1; Type=Frameshift; Positions=Several; Sequence=BAD92929.1; Type=Erroneous
initiation;
Secondary accessions: B4DPH7 F5GWA8 F5H5J1 O95820 Q59EW9 Q96TC1
Alternative splicing: 5 isoforms:  Q8TCC7-1   Q8TCC7-2   Q8TCC7-5   Q8TCC7-3   Q8TCC7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC22A8: NX_Q8TCC7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TCC7

    • SLC22A8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001171661.1  NP_001171662.1  NP_001171665.1  NP_004245.2  

    ENSEMBL proteins: 
     ENSP00000337335   ENSP00000441658   ENSP00000443368   ENSP00000311463   ENSP00000398548  
    Reactome Protein details: Q8TCC7
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC22A8 Proteins
    Novus Biologicals SLC22A8 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC22A8

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane IDA15037815


    SLC22A8 for ontologies           About GeneDecksing



    SLC22A8 Antibody Products: 
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    Protein Domains /
    Families
    for SLC22A8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC22A8 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR004749 Orgcat_transp
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8TCC7

    ProtoNet protein and cluster: Q8TCC7

    1 Blocks protein family: IPB005829 Sugar transporter superfamily

    UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family


    Function
    for SLC22A8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7
    Function: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions,
    especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports
    benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D),
    p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA)

         Genatlas biochemistry entry for SLC22A8:
    solute carrier protein family 22,member A8,polyspecific transporter for organic cations,mediating the coupled exchange
    of alpha-ketoglutarate with multiple organic ions,expressed strongly in kidney,weakly in brain

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC22A8
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC22A8:
    hsa-miR-4271 hsa-miR-3117-3p hsa-miR-625 hsa-miR-3202 hsa-miR-1258 hsa-miR-1207-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC22A8 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding IEA--
    GO:0005452inorganic anion exchanger activity IDA15037815
    GO:0008514organic anion transmembrane transporter activity IEA--
    GO:0015075ion transmembrane transporter activity ----
    GO:0015651quaternary ammonium group transmembrane transporter activity IEA--


    SLC22A8 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SLC22A8:
     Decreased viability with cispl  Increased circadian period len 

    Animal Models:
         Mouse knock-out Slc22a8tm1Ngm for SLC22A8
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc22a8):
     homeostasis/metabolism  renal/urinary system 

    SLC22A8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC22A8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Pravastatin Pathway, Pharmacokinetics
    		Pravastatin Pathway, Pharmacokinetics1.00
    		Methotrexate Pathway (Brain Cell), Pharmacokinetics0.33
    		Methotrexate Pathway, Pharmacokinetics0.47
    3Organic cation/anion/zwitterion transport
    		Organic cation/anion/zwitterion transport1.00
    		Organic anion transport0.38
    4Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    		Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics1.00
    5Bile secretion
    		Bile secretion1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SLC22A8
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Organic cation/anion/zwitterion transport
    Organic anion transport

    5/6 PharmGKB Pathways for SLC22A8 (see all 6)
        Methotrexate Pathway (Brain Cell), Pharmacokinetics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics
    Methotrexate Pathway, Pharmacokinetics
    Pravastatin Pathway, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics

    1         Kegg Pathway  (Kegg details for SLC22A8):
        Bile secretion


    SLC22A8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC22A8

    1 Interacting protein for SLC22A8 (Q8TCC73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCZQ055133I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009636response to toxin IEA--
    GO:0015697quaternary ammonium group transport ----
    GO:0015711organic anion transport ----
    GO:0031427response to methotrexate IEA--
    GO:0034635glutathione transport IEA--


    SLC22A8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC22A8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC22A8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC22A8

    10/64 DrugBank Compounds for SLC22A8 (see all 64)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ProbenecidProbenecid Acid (see all 2)57-66-9targetinhibitor10224140 12488248 11669456 11426832 12130730 10592235
    transporterinhibitor10224140 12488248 11669456 11426832 12130730 10592235 20519552 11408557 14978359 10224140 11306713 11669456 11961115 11426832 14762099 12130730 20460822 12679720
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transportersubstrate inhibitor14586168 11408557 15100168 10224140 11306713 10049739 11669456 11961115 14762099 11861777 12679720 12011098
    Cimetidine-- 51481-61-9transportersubstrate inhibitor14586168 15100168 16291876 14978359 10224140 11306713 11669456 11961115 14762099 12679720 15496291
    Penicillin G-- 61-33-6transportersubstrate inhibitor10224140 11306713 11669456 11961115 14762099 11861777 12130730 12679720
    Conjugated EstrogensEstrogens (see all 10)438-67-5transportersubstrate inhibitor15100168 10224140 11306713 11961115 14762099 12679720 12011098
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor10224140 11306713 11669456 14762099 12130730 12679720
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate inhibitor10224140 11306713 14762099 12130730 20460822
    Taurocholic Acid-- 81-24-3transportersubstrate inhibitor11408557 10224140 11306713 14762099 12011098
    Cefacetrile7-Cyanacetylamino-cephalosporansaeure (see all 4)10206-21-0transportersubstrate inhibitor15618660 11909604 12005172 10411577
    Aciclovir9-Hyroxyethoxymethylguanine (see all 8)59277-89-3transportersubstrate inhibitor11306713 11861798 12358729

    10/16 Novoseek chemical compound relationships for SLC22A8 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrone sulfate 86.2 5 17674156 (1), 14586168 (1), 17639024 (1), 12605306 (1)
    probenecid 81.9 2 18930752 (1), 15820748 (1)
    glutaric acid 78 2 20237588 (1), 15820748 (1)
    indoxyl sulfate 77.4 2 17264878 (1), 19837111 (1)
    benzylpenicillin 75.2 1 15846473 (1)
    cimetidine 62.8 1 16997449 (1)
    thiopurine 60.4 1 15287899 (1)
    pravastatin 58.2 3 14729100 (1), 12811365 (1)
    alpha-ketoglutarate 57.6 1 15319545 (1)
    dicarboxylate 57.5 1 15319545 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC22A8 / S22A8 

    Transcripts
    for SLC22A8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC22A8 gene (4 alternative transcripts): 
    NM_001184732.1  NM_001184733.1  NM_001184736.1  NM_004254.3  

    Unigene Cluster for SLC22A8:

    Solute carrier family 22 (organic anion transporter), member 8
    Hs.266223  [show with all ESTs]
    Unigene Representative Sequence: AB209692
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539841(uc001nwn.1) ENST00000336232(uc001nwp.2 uc009yom.3 uc009yon.3 uc001nwo.3 uc010rmm.2)
    ENST00000451262 ENST00000545207 ENST00000535878 ENST00000311438 ENST00000430500
    ENST00000542795 ENST00000542904 ENST00000544707

    miRNA
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    hsa-miR-4271 hsa-miR-3117-3p hsa-miR-625 hsa-miR-3202 hsa-miR-1258 hsa-miR-1207-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC22A8 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB042505.1 AB209692.1 AK123243.1 AK298351.1 AK307850.1 AK313187.1 BC022387.1 

    6 DOTS entries:

    DT.109514  DT.100742934  DT.86821046  DT.91756860  DT.99974907  DT.120760606 

    24/46 AceView cDNA sequences (see all 46):

    CD672262 H20273 AB042505 NM_004254 BM923908 BM707779 BU732935 BM686171 
    BM707837 BC022387 BU733288 AK123243 H41333 BI762768 AA877205 AW305206 
    AI245108 AI460025 AW025372 BI760120 BX096071 BG427793 BG432030 H18608 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A8 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:                                -     -                       -                                               -                                       
    SP2:                                -     -                       -                                               -                                       
    SP3:                                      -                       -                                                                                       
    SP4:              -     -           -     -                       -                                                                                       
    SP5:                                                              -                                                                                       


    ECgene alternative splicing isoforms for SLC22A8

    Expression
    for SLC22A8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC22A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGATCCAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC22A8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC22A8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC22A8

    SOURCE GeneReport for Unigene cluster: Hs.266223

    UniProtKB/Swiss-Prot: S22A8_HUMAN, Q8TCC7
    Tissue specificity: Expressed in kidney

        SABiosciences Expression via Pathway-Focused PCR Array including SLC22A8: 
              Drug Transporters in human mouse rat

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    In Situ
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    Orthologs
    for SLC22A8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A8 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 4)    		 --
    		 51(a)
    50(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 AAWZ02037376(3916-15587)
    AAWZ02038813(6-2374)
    zebrafish
    (Danio rerio)    		 Actinopterygii oat6
    CU638714.26
    		 --
    		 47(a)
    39(a)
    		 1 ↔ many
    possible ortholog
    		 21(27873057-27888716)
    24(20432232-20434293)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG60066
    CG315306
    (see all 6)    		 --
    		 21(a)
    17(a)
    (see all 6)    		 many ↔ many
    possible ortholog
    (see all 6)    		 3R(11981040-11997488)
    3R(576129-598807)
    worm
    (Caenorhabditis elegans)    		 Secernentea B0252.36
    T12B3.26
    (see all 24)    		 Protein T12B3.2
    (see all 24)    		 23(a)
    19(a)
    (see all 24)    		 possible ortholog
    possible ortholog
    (see all 24)    		 II(6902826-6907713)
    IV(7376886-7378889)


    ENSEMBL Gene Tree for SLC22A8 (if available)
    TreeFam Gene Tree for SLC22A8 (if available) 

    Paralogs
    for SLC22A8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC22A8 gene
    SLC22A12  SLC22A102  SLC22A152  SLC22A72  SLC22A122  SLC22A52  SLC22A112  SLC22A42  
    SLC22A242  SLC22A132  SLC22A22  SLC22A92  SLC22A62  SLC22A252  SLC22A162  SLC22A32  
    18/21 SIMAP similar genes for SLC22A8 using alignment to 2 protein entries:     S22A8_HUMAN (see all proteins) (see all similar genes):
    SLC22A6    SLC22A20    SLC22A11    HMFN2567    SLC22A12    SLC22A10
    SLC22A7    SLC22A13    OAT7    SLC22A9    SLC22A24    SLC22A25
    UST6    SLC22A5    SLC22A3    SLC22A14    SLC22A2    SLC22A4

    SLC22A8 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC22A8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/403 NCBI SNPs in SLC22A8 are shown (see all 403)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs588550551,2
    		C,--62759859(+) ACAGCG/AGTCAG 4 -- ds50013Minor allele frequency- A:0.27WA 122
    rs747580981,2
    		--62759942(+) CTATCA/TGCTGG 4 -- ds50010--------
    rs1880434171,2
    		--62759944(+) ATCTGC/TTGGGC 4 -- ds50010--------
    rs1114363311,2
    		C,--62759968(+) ATAGAC/TCAGAG 4 -- ds50010--------
    rs1380528751,2
    		--62759986(+) GTGATC/GAGGGG 4 -- ds50010--------
    rs1925049601,2
    		--62759993(+) GGGGAA/TAGAAA 4 -- ds50010--------
    rs1838881231,2
    		--62760030(+) GTCTGC/TAGCCA 4 -- ds50010--------
    rs754740131,2
    		C,F,--62760038(+) CCACTC/ATGGGC 4 -- ds50013Minor allele frequency- A:0.17WA CSA 122
    rs1160778751,2
    		F,--62760063(+) GCTCAT/CATGCA 4 -- ds50012Minor allele frequency- C:0.02WA EA 238
    rs1882219471,2
    		--62760112(+) CAGGCA/GTGGTG 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC22A8 (62756626 - 62783317 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC22A8
         1 CNV: 47961

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    Disorders / Diseases
    for SLC22A8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC22A8 for disorders           About GeneDecksing

    OMIM gene information: 607581    OMIM disorders: --

    8 diseases for SLC22A8:    About MalaCards
    extrahepatic cholestasis    osteosclerosis    cholestasis    choroiditis
    nephropathy    hypertension    cerebritis    retinitis

    Genetic Association Database (GAD): SLC22A8
    Human Genome Epidemiology (HuGE) Navigator: SLC22A8 (6 documents)

    Export disorders for SLC22A8 gene to outside databases

    Publications
    for SLC22A8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC22A8 gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with SLC22A8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PubMed id 10049739)1, 2, 3, 7 Race J.E.... Holtzman E.J. (1999)
    2. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. (PubMed id 16291576)1, 2, 4, 9 Erdman A.R.... Giacomini K.M. (2006)
    3. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. (PubMed id 12811365)1, 2, 4, 9 Nishizato Y.... Sugiyama Y. (2003)
    4. Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. (PubMed id 14586168)1, 2, 7, 9 Bakhiya A.... Wolff N. (2003)
    5. Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. (PubMed id 15846473)1, 2, 9 Tahara H.... Sugiyama Y. (2005)
    6. Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. (PubMed id 16455804)1, 2, 9 Tahara H.... Sugiyama Y. (2006)
    7. Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). (PubMed id 15644426)1, 2 Srimaroeng C.... Pritchard J.B. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Gene expression levels and immunolocalization of organic ion transporters in the human kidney. (PubMed id 11912245)1, 2 Motohashi H.... Inui K. (2002)
    10. Human organic anion transporters mediate the transport of tetracycline. (PubMed id 11855680)1, 7 Babu E.... Endou H. (2002)

    External Searches for SLC22A8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing SLC22A8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9376 HGNC: 10972 AceView: SLC22A8 Ensembl:ENSG00000149452 euGenes: HUgn9376
    ECgene: SLC22A8 Kegg: 9376 H-InvDB: SLC22A8

    Other Databases showing SLC22A8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC22A8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC22A8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC22A8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC22A8 gene:
    Search GeneIP for patents involving SLC22A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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