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SLC22A7 Gene

protein-coding   GIFtS: 55
GCID: GC06P043263

Solute Carrier Family 22 (Organic Anion Transporter), Member...

  See SLC22A7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22 (Organic Anion Transporter), Member 71 2     NLT2 3
OAT22 3 5     hOAT22 3
Novel Liver Transporter2 3     Liver-Specific Transporter2
Organic Anion Transporter 22 3     Solute Carrier Family 22 Member 72

External Ids:    HGNC: 109711   Entrez Gene: 108642   Ensembl: ENSG000001372047   OMIM: 6049955   UniProtKB: Q9Y6943   

Export aliases for SLC22A7 gene to outside databases

Previous GC identifers: GC06P043268 GC06P043312 GC06P043373 GC06P042985


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A7 Gene:
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions,
some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be
localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different
isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC22A7 Gene:
SLC22A7 (solute carrier family 22 (organic anion transporter), member 7) is a protein-coding gene. Diseases associated with SLC22A7 include citrullinemia, and citrin deficiency. GO annotations related to this gene include sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22A7_HUMAN, Q9Y694
Function: Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2,
prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate,
allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate

Gene Wiki entry for SLC22A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A7 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A7 promoter sequence
   Search Chromatin IP Primers for SLC22A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

SLC22A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043263:  view genomic region     (about GC identifiers)

Start:
43,263,432 bp from pter      End:
43,273,276 bp from pter
Size:
9,845 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S22A7_HUMAN, Q9Y694 (See protein sequence)
Recommended Name: Solute carrier family 22 member 7  
Size: 548 amino acids; 60026 Da
Secondary accessions: B2CZX6 Q5T046 Q5T048 Q5T050 Q9H2W5
Alternative splicing: 4 isoforms:  Q9Y694-1   Q9Y694-2   Q9Y694-3   Q9Y694-4   

Explore the universe of human proteins at neXtProt for SLC22A7: NX_Q9Y694

Explore proteomics data for SLC22A7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn91
  • Modification sites at PhosphoSitePlus

  • See SLC22A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006663.2  NP_696961.2  

    ENSEMBL proteins: 
     ENSP00000416052   ENSP00000411818   ENSP00000434707   ENSP00000361670   ENSP00000361666  
     ENSP00000361655   ENSP00000393836  
    Reactome Protein details: Q9Y694

    SLC22A7 Human Recombinant Protein Products:

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    Novus Biologicals SLC22A7 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC22A7 

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    Search eBioscience for ELISAs for SLC22A7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic anion transporter 2
    Organic anion transporters (OATs)

    4 InterPro protein domains:
     IPR004749 Orgcat_transp
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9Y694

    ProtoNet protein and cluster: Q9Y694

    UniProtKB/Swiss-Prot: S22A7_HUMAN, Q9Y694
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22A7_HUMAN, Q9Y694
    Function: Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2,
    prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate,
    allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate
    Biophysicochemical properties: Kinetic parameters: KM=713 nM for prostaglandin E2; KM=440 uM for tetracycline;

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015075ion transmembrane transporter activity ----
    GO:0015347sodium-independent organic anion transmembrane transporter activity TAS9650585
    GO:0022857transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC22A7           About GenesLikeMe


    Animal Models:
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    miRNA
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    hsa-miR-3163 hsa-miR-409-3p hsa-miR-1255a hsa-miR-3662 hsa-miR-29c hsa-miR-29a hsa-miR-26b* hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A7 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22A7_HUMAN, Q9Y694: Basolateral cell membrane; Multi-pass membrane protein. Note=Apical side of the renal tubule
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9650585
    GO:0016020membrane TAS9650585
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IEA--

    Find genes that share ontologies with SLC22A7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC22A7 About    
    See pathways by source

    SuperPathContained pathways About
    1Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Organic anion transport0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    3Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    4Bile secretion
    Bile secretion


    Find genes that share SuperPaths with SLC22A7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC22A7
        Fluoropyrimidine Activity

    1 Reactome Pathway for SLC22A7
        Organic anion transport

    2 PharmGKB Pathways for SLC22A7
        Fluoropyrimidine Pathway, Pharmacokinetics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

    1 Kegg Pathway  (Kegg details for SLC22A7):
        Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC22A7: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC22A7

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC22A7 (ENSP000003616664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC22A1ENSP000003559304STRING: ENSP00000355930
    SLC22A2ENSP000003559204STRING: ENSP00000355920
    SLC22A3ENSP000002753004STRING: ENSP00000275300
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015711organic anion transport TAS9650585
    GO:0034220ion transmembrane transport ----
    GO:0035634response to stilbenoid IEA--
    GO:0055085transmembrane transport TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A7 (S22A7)

    5 HMDB Compounds for SLC22A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dehydroepiandrosterone(+)-Dehydroisoandrosterone (see all 42)53-43-0--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--
    SodiumSodium (see all 2)7440-23-5--

    Selected DrugBank Compounds for SLC22A7 (see all 37)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DinoprostoneDinoprostone Prostaglandin E2 (see all 3)363-24-6transportersubstrate inhibitor11907186 9650585 12065749 11504818
    Ketoprofen-- 22071-15-4transporterinhibitor10991954 9650585 11504818 12130730
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transportersubstrate9650585 11327718 12065749
    CefoperazoneCefoperazono [inn-spanish] (see all 2)62893-19-0transporterinhibitor9650585 12065749 12650826
    Salicyclic acid2-Carboxyphenol (see all 10)69-72-7transportersubstrate9650585 12065749 11504818
    Cimetidine-- 51481-61-9transportersubstrate inhibitor12065749 10224140
    EnalaprilEnalapril Maleate (see all 4)75847-73-3transporterinhibitor9650585 12065749
    ErythromycinEM (see all 7)114-07-8transporterinhibitor12065749 15708966
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate9650585 11327718
    Probenecid-- 57-66-9transporterinhibitor12023506 14978359

    4 Novoseek inferred chemical compound relationships for SLC22A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 85.1 6 11023036 (1), 19661216 (1), 15499184 (1), 19074973 (1)
    pravastatin 57.4 2 7811739 (1), 11356905 (1)
    bumetanide 48.1 1 16256982 (1)
    glucose 6-phosphate 47 3 15864125 (1), 15319464 (1), 15757503 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A7 gene (2 alternative transcripts): 
    NM_006672.3  NM_153320.2  

    Unigene Cluster for SLC22A7:

    Solute carrier family 22 (organic anion transporter), member 7
    Hs.485438  [show with all ESTs]
    Unigene Representative Sequence: NM_153320
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480882 ENST00000487175 ENST00000451757 ENST00000449231 ENST00000498232
    ENST00000372589(uc010jyl.1 uc003out.3) ENST00000372585(uc021yzt.1)
    ENST00000372574(uc003ous.3) ENST00000436107
    miRNA
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    Additional mRNA sequence: 

    AF210455.1 AK290796.1 AK290806.1 AK309570.1 AK314822.1 AY050498.1 BC017963.1 BC033805.1 

    12 DOTS entries:

    DT.100019750  DT.100759232  DT.443865  DT.95268336  DT.100759230  DT.121405390  DT.421185  DT.97792715 
    DT.97834798  DT.121405579  DT.121405719  DT.40273127 

    Selected AceView cDNA sequences (see all 64):

    BX112596 AA702356 BF196005 NM_153320 NM_006672 R29132 N74370 BM923779 
    AI016020 BC017963 R00498 CB161620 BF197339 AW237757 BX118061 BX496425 
    N74422 BI761074 BI517857 BI759441 R00599 AW976604 BI759340 BM923554 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                            -           -           -                       -           -                                       
    SP2:                                                        -           -                       -           -                             -         
    SP3:                    -     -     -                       -                                                                                       
    SP4:              -     -     -     -           -           -           -                                                                           
    SP5:                                                        -           -                                                                           


    ECgene alternative splicing isoforms for SLC22A7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCCAACA
    SLC22A7 Expression
    About this image

    SLC22A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485438

    UniProtKB/Swiss-Prot: S22A7_HUMAN, Q9Y694
    Tissue specificity: Expressed in liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC22A7: 
              Drug Transporters in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC22A7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a71 , 5 solute carrier family 22 (organic anion transporter), more1, 5 82.51(n)1
    78.98(a)1
      17 (22.90 cM)5
    1081141  NM_144856.21  NP_659105.21 
     464321855 
    chicken
    (Gallus gallus)
    Aves SLC22A71 solute carrier family 22 (organic anion transporter), more 60(n)
    54.02(a)
      416712  NM_001199438.1  NP_001186367.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC22A76
    solute carrier family 22 (organic anion transporte...
    51(a)
    1 ↔ 1
    2(143560017-143588585)
    zebrafish
    (Danio rerio)
    Actinopterygii slc22a7a1 solute carrier family 22 (organic anion transporter), more 53.57(n)
    47.93(a)
      794188  NM_001083861.1  NP_001077330.1 


    ENSEMBL Gene Tree for SLC22A7 (if available)
    TreeFam Gene Tree for SLC22A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A7 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  
    SLC22A132  SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A162  SLC22A32  SLC22A252  
    Selected SIMAP similar genes for SLC22A7 using alignment to 4 protein entries:     S22A7_HUMAN (see all proteins) (see all similar genes):
    SLC22A8    SLC22A16    SVOPL    UST6    SLC22A20    SLC22A6
    SLC22A10    SLC22A13    SLC22A25    SLC22A11    SLC22A24    SLC22A5
    OAT7    SLC22A4    SLC22A9    SLC22A12    SLC22A15    SLC22A14

    Find genes that share paralogs with SLC22A7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A7 (see all 280)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28416521,2
    C,F,H--43175067(-) TGACGC/ACTTAG 2 -- us2k118Minor allele frequency- A:0.04NS EA WA NA CSA 858
    rs1868043281,2
    --43175069(+) AAGTCA/GTCACA 2 -- us2k10--------
    rs709536671,2
    C,F--43175076(+) CACAGC/GCAATG 2 -- us2k16Minor allele frequency- G:0.02NS WA 306
    rs1445393921,2
    --43175132(+) TTCAGA/GGTATT 2 -- us2k10--------
    rs1901306021,2
    --43175155(+) CACTGC/GATGGG 2 -- us2k10--------
    rs1827224801,2
    --43175320(+) GAGGTA/GTCTCC 2 -- us2k10--------
    rs709536691,2
    C,F--43175418(+) ACATGC/TCAATG 2 -- us2k15Minor allele frequency- T:0.01NS 188
    rs680295731,2
    C,F--43175431(+) CTGGTG/ATGTGC 2 -- us2k16Minor allele frequency- A:0.01NS WA 192
    rs1883886631,2
    --43175457(+) AGGGAC/GCATGT 2 -- us2k10--------
    rs28416511,2
    C,F,H--43175557(-) CTTCTA/GCTGCC 2 -- us2k121Minor allele frequency- G:0.02NS EA NA WA CSA 964

    HapMap Linkage Disequilibrium report for SLC22A7 (43263432 - 43273276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC22A7:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6840n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A7
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604995    OMIM disorders: --

    2 diseases for SLC22A7:    
    About MalaCards
    citrullinemia    citrin deficiency


    Find genes that share disorders with SLC22A7           About GenesLikeMe

    2 Novoseek inferred disease relationships for SLC22A7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperbilirubinemia 62.2 3 15965581 (1), 20514852 (1), 15319464 (1)
    g6pd deficiency 61.8 1 15319464 (1)

    Genetic Association Database (GAD): SLC22A7
    Human Genome Epidemiology (HuGE) Navigator: SLC22A7 (1 document)

    Export disorders for SLC22A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A7 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with SLC22A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. (PubMed id 11907186)1, 2, 7 Kimura H.... Endou H. (J. Pharmacol. Exp. Ther. 2002)
    2. Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. (PubMed id 12023506)1, 2, 7 Enomoto A.... Endou H. (J. Pharmacol. Exp. Ther. 2002)
    3. Human organic anion transporters mediate the transport of tetracycline. (PubMed id 11855680)1, 2, 7 Babu E.... Endou H. (Jpn. J. Pharmacol. 2002)
    4. Isolation of a family of organic anion transporters from human liver and kidney. (PubMed id 11327718)1, 2, 7 Sun W.... Erion M.D. (Biochem. Biophys. Res. Commun. 2001)
    5. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. (PubMed id 9650585)1, 3, 7 Sekine T....Endou H. (FEBS Lett. 1998)
    6. Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). (PubMed id 15901346)2, 7, 9 Kobayashi Y....Yamamoto T. (J. Pharm. Pharmacol. 2005)
    7. Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2--&gt;p21.1 using radiation hybrids. (PubMed id 10773670)1, 3, 9 Kok L.D....Waye M.M. (Cytogenet. Cell Genet. 2000)
    8. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    9. Identification of genetic polymorphisms of human OAT1 and OAT2 genes and their relationship to hOAT2 expression in human liver. (PubMed id 19854166)1, 9 Shin H.J....Shin J.G. ( international journal of clinical chemistry 2010)
    10. Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. (PubMed id 15708966)7, 9 Kobayashi Y....Yamamoto T. (Drug Metab. Dispos. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10864 HGNC: 10971 AceView: SLC22A7 Ensembl:ENSG00000137204 euGenes: HUgn10864
    ECgene: SLC22A7 Kegg: 10864 H-InvDB: SLC22A7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A7 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/slc22a7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A7 gene:
    Search GeneIP for patents involving SLC22A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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