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Aliases for SLC22A7 Gene

Aliases for SLC22A7 Gene

  • Solute Carrier Family 22 Member 7 2 3 5
  • Solute Carrier Family 22 (Organic Anion Transporter), Member 7 2 3
  • Organic Anion Transporter 2 3 4
  • Novel Liver Transporter 3 4
  • HOAT2 3 4
  • OAT2 3 4
  • NLT 3 4
  • Organic Anion Transporter 11 3
  • Liver-Specific Transporter 3
  • HOAT11 3

External Ids for SLC22A7 Gene

Previous GeneCards Identifiers for SLC22A7 Gene

  • GC06P043268
  • GC06P043312
  • GC06P043373
  • GC06P043263
  • GC06P042985

Summaries for SLC22A7 Gene

Entrez Gene Summary for SLC22A7 Gene

  • The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A7 Gene

SLC22A7 (Solute Carrier Family 22 Member 7) is a Protein Coding gene. Diseases associated with SLC22A7 include Bilirubin Metabolic Disorder. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Pyrimidine metabolism (REACTOME). GO annotations related to this gene include transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A6.

UniProtKB/Swiss-Prot for SLC22A7 Gene

  • Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.

Gene Wiki entry for SLC22A7 Gene

Additional gene information for SLC22A7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A7 Gene

Genomics for SLC22A7 Gene

Regulatory Elements for SLC22A7 Gene

Enhancers for SLC22A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H043334 1.1 Ensembl ENCODE 25.8 +39.6 39592 1 ELF3 PKNOX1 ARID4B DMAP1 ZBTB40 ZSCAN9 RAD21 RFX5 SLC30A9 SCRT2 SLC22A7 RPL12P47 CRIP3 ZNF318 DLK2 LRRC73 POLR1C YIPF3 RPL34P14 GC06P043362
GH06H043367 1.4 ENCODE dbSUPER 13.8 +73.4 73393 3 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF318 RPL34P14 SLC22A7 CUL7 SLC35B2 ABCC10 POLH RPL24P4 GTPBP2 RPS2P29
GH06H043308 1.2 Ensembl ENCODE 14.2 +13.0 13007 1 HDGF ARID4B DMAP1 YY1 GLIS2 SP3 MXD4 NFYC REST PPARG SLC22A7 ABCC10 RPL7L1 ENSG00000271970 ZNF318 POLR1C CUL7 CRIP3
GH06H043382 1.4 Ensembl ENCODE dbSUPER 11.7 +88.2 88165 2 PKNOX1 TBL1XR1 BMI1 YBX1 BATF YY1 FOS ATF7 ETV6 RUNX3 SLC22A7 ABCC10 RPL12P47 CRIP3 DLK2 TTBK1 DNPH1 TJAP1 RNU6-1113P LRRC73
GH06H043261 1.3 FANTOM5 ENCODE dbSUPER 12.3 -33.3 -33329 1 ELF3 SAP130 CEBPG RAD21 ZIC2 ZNF644 ZSCAN9 RARA TEAD3 GLIS2 DNPH1 SLC22A7 ZNF318 RPL12P47 CRIP3 DLK2 ENSG00000245261 CUL9 YIPF3 POLR1C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC22A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A7 Gene

Chromosome:
6
Start:
43,295,694 bp from pter
End:
43,305,538 bp from pter
Size:
9,845 bases
Orientation:
Plus strand

Genomic View for SLC22A7 Gene

Genes around SLC22A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A7 Gene

Proteins for SLC22A7 Gene

  • Protein details for SLC22A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y694-S22A7_HUMAN
    Recommended name:
    Solute carrier family 22 member 7
    Protein Accession:
    Q9Y694
    Secondary Accessions:
    • B2CZX6
    • Q5T046
    • Q5T048
    • Q5T050
    • Q9H2W5

    Protein attributes for SLC22A7 Gene

    Size:
    548 amino acids
    Molecular mass:
    60026 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A7 Gene

Post-translational modifications for SLC22A7 Gene

  • Glycosylation at Asn91
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A7 Gene

Domains & Families for SLC22A7 Gene

Gene Families for SLC22A7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A7 Gene

Suggested Antigen Peptide Sequences for SLC22A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y694

UniProtKB/Swiss-Prot:

S22A7_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A7: view

Function for SLC22A7 Gene

Molecular function for SLC22A7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=713 nM for prostaglandin E2 {ECO:0000269 PubMed:11855680, ECO:0000269 PubMed:11907186}; KM=440 uM for tetracycline {ECO:0000269 PubMed:11855680, ECO:0000269 PubMed:11907186};
UniProtKB/Swiss-Prot Function:
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.

Phenotypes From GWAS Catalog for SLC22A7 Gene

Gene Ontology (GO) - Molecular Function for SLC22A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0005515 protein binding IPI 15846844
GO:0008514 organic anion transmembrane transporter activity IEA --
GO:0015301 anion:anion antiporter activity TAS --
GO:0015347 sodium-independent organic anion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC22A7: view
genes like me logo Genes that share phenotypes with SLC22A7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A7

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC22A7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A7 Gene

Localization for SLC22A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A7 Gene

Basolateral cell membrane; Multi-pass membrane protein. Note=Apical side of the renal tubule.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A7 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC22A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9650585
GO:0016020 membrane TAS,IEA 9650585
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC22A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A7 Gene

Pathways & Interactions for SLC22A7 Gene

genes like me logo Genes that share pathways with SLC22A7: view

Gene Ontology (GO) - Biological Process for SLC22A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015711 organic anion transport TAS 9650585
GO:0043252 sodium-independent organic anion transport IBA --
genes like me logo Genes that share ontologies with SLC22A7: view

No data available for SIGNOR curated interactions for SLC22A7 Gene

Drugs & Compounds for SLC22A7 Gene

(45) Drugs for SLC22A7 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bumetanide Approved Pharma Agonist, Transporter, inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 17
Docetaxel Approved May 1996, Investigational Pharma Transporter, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1993
Allopurinol Approved Pharma Transporter, substrate 149
Aspirin Approved, Vet_approved Pharma Channel blocker, Transporter, substrate 1196
Cefalotin Approved, Vet_approved Pharma Transporter, inhibitor 0

(3) Additional Compounds for SLC22A7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-ene-Valproic acid
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC22A7: view

Transcripts for SLC22A7 Gene

Unigene Clusters for SLC22A7 Gene

Solute carrier family 22 (organic anion transporter), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC22A7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - -
SP6: - -
SP7:
SP8: - - - -
SP9:

Relevant External Links for SLC22A7 Gene

GeneLoc Exon Structure for
SLC22A7
ECgene alternative splicing isoforms for
SLC22A7

Expression for SLC22A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A7 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A7 Gene

This gene is overexpressed in Liver (x39.4) and Kidney - Cortex (x11.9).

Protein differential expression in normal tissues from HIPED for SLC22A7 Gene

This gene is overexpressed in Tlymphocyte (31.0), Liver (19.6), and Heart (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A7 Gene



Protein tissue co-expression partners for SLC22A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC22A7 Gene:

SLC22A7

SOURCE GeneReport for Unigene cluster for SLC22A7 Gene:

Hs.485438

mRNA Expression by UniProt/SwissProt for SLC22A7 Gene:

Q9Y694-S22A7_HUMAN
Tissue specificity: Expressed in liver and kidney.

Evidence on tissue expression from TISSUES for SLC22A7 Gene

  • Liver(4.7)
  • Kidney(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with SLC22A7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A7 Gene

Orthologs for SLC22A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A7 33 34
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia SLC22A7 33 34
  • 87.18 (n)
rat
(Rattus norvegicus)
Mammalia Slc22a7 33
  • 83.05 (n)
mouse
(Mus musculus)
Mammalia Slc22a7 33 16 34
  • 82.51 (n)
dog
(Canis familiaris)
Mammalia SLC22A7 33 34
  • 81.67 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC22A7 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A7 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A7 33 34
  • 60 (n)
lizard
(Anolis carolinensis)
Reptilia SLC22A7 34
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc22a7a 33 34
  • 53.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8654 35
  • 32 (a)
CG13610 35
  • 31 (a)
CG3790 35
  • 31 (a)
Orct 35
  • 31 (a)
CG6126 35
  • 30 (a)
CG6600 35
  • 30 (a)
CG14857 35
  • 27 (a)
CG16727 35
  • 27 (a)
CG5592 35
  • 27 (a)
CG17752 35
  • 26 (a)
CG6356 35
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK455.8a 35
  • 29 (a)
ZK455.8b 35
  • 29 (a)
K05F1.6 35
  • 26 (a)
Y82E9BR.16 35
  • 25 (a)
oat-1 35
  • 24 (a)
Species where no ortholog for SLC22A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A7 Gene

ENSEMBL:
Gene Tree for SLC22A7 (if available)
TreeFam:
Gene Tree for SLC22A7 (if available)

Paralogs for SLC22A7 Gene

Variants for SLC22A7 Gene

Sequence variations from dbSNP and Humsavar for SLC22A7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000109187 -- 43,304,762(+) TCTGC(A/C)GCAGG intron-variant, utr-variant-3-prime
rs1000227416 -- 43,301,500(+) AATAG(A/G)GAGGG intron-variant
rs1000285504 -- 43,293,924(+) CATTA(C/T)CACCA upstream-variant-2KB
rs1000561772 -- 43,299,748(+) CAGCC(C/T)TGGCT intron-variant, reference, synonymous-codon
rs1000698327 -- 43,294,402(+) TACCA(C/T)CATCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC22A7 Gene

Variant ID Type Subtype PubMed ID
esv3446612 CNV duplication 20981092
nsv1017398 CNV gain 25217958
nsv479044 CNV novel sequence insertion 20440878
nsv602998 CNV loss 21841781
nsv602999 CNV loss 21841781
nsv950170 CNV deletion 24416366

Variation tolerance for SLC22A7 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A7 Gene

Disorders for SLC22A7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC22A7 Gene - From: Novoseek

Disorder Aliases PubMed IDs
bilirubin metabolic disorder
  • hereditary hyperbilirubinemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC22A7

Genetic Association Database (GAD)
SLC22A7
Human Genome Epidemiology (HuGE) Navigator
SLC22A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A7
genes like me logo Genes that share disorders with SLC22A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A7 Gene

Publications for SLC22A7 Gene

  1. Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. (PMID: 12023506) Enomoto A … Endou H (The Journal of pharmacology and experimental therapeutics 2002) 3 4 25 60
  2. Human organic anion transporters mediate the transport of tetracycline. (PMID: 11855680) Babu E … Endou H (Japanese journal of pharmacology 2002) 3 4 25 60
  3. Isolation of a family of organic anion transporters from human liver and kidney. (PMID: 11327718) Sun W … Erion MD (Biochemical and biophysical research communications 2001) 3 4 25 60
  4. Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2-->p21.1 using radiation hybrids. (PMID: 10773670) Kok LD … Waye MM (Cytogenetics and cell genetics 2000) 2 3 22 60
  5. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. (PMID: 9650585) Sekine T … Endou H (FEBS letters 1998) 2 3 25 60

Products for SLC22A7 Gene

Sources for SLC22A7 Gene

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