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SLC22A6 Gene

protein-coding   GIFtS: 64
GCID: GC11M062744

Solute Carrier Family 22 (Organic Anion Transporter), Member...

  See SLC22A6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22 (Organic Anion Transporter), Member 61 2     PAH Transporter2 3
OAT12 3 5     HOAT12
PAHT2 3 5     ROAT12
Organic Anion Transporter 12 3     Para-Aminohippurate Transporter2
Renal Organic Anion Transporter 12 3     Solute Carrier Family 22 Member 62
hPAHT2 3     hOAT13
hROAT12 3     

External Ids:    HGNC: 109701   Entrez Gene: 93562   Ensembl: ENSG000001979017   OMIM: 6075825   UniProtKB: Q4U2R83   

Export aliases for SLC22A6 gene to outside databases

Previous GC identifers: GC11M065256 GC11M064319 GC11M062994 GC11M062519 GC11M062500 GC11M059073


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A6 Gene:
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions,
some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to
the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC22A6 Gene:
SLC22A6 (solute carrier family 22 (organic anion transporter), member 6) is a protein-coding gene. Diseases associated with SLC22A6 include bipolar i disorder. GO annotations related to this gene include inorganic anion exchanger activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8
Function: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion
exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of
endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of
2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of
p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD),
2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and
3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine
(PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by
p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen,
glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC),
S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol,
phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin,
bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate

Gene Wiki entry for SLC22A6 (Organic anion transporter 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A6 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A6 promoter sequence
   Search Chromatin IP Primers for SLC22A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

SLC22A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062744:  view genomic region     (about GC identifiers)

Start:
62,703,857 bp from pter      End:
62,752,495 bp from pter
Size:
48,639 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8 (See protein sequence)
Recommended Name: Solute carrier family 22 member 6  
Size: 563 amino acids; 61816 Da
Secondary accessions: A8MY93 B2D0R6 O95187 O95742 Q7LDA0 Q8N192 Q9NQA6 Q9NQC2 Q9UBG6 Q9UEQ8
Alternative splicing: 4 isoforms:  Q4U2R8-1   Q4U2R8-2   Q4U2R8-3   Q4U2R8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC22A6: NX_Q4U2R8

Explore proteomics data for SLC22A6 at MOPED

Post-translational modifications: 

  • Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper
    targeting of the transporter to the plasma membrane1
  • Glycosylation2 at Asn39, Asn56, Asn92, Asn97, Asn113
  • Modification sites at PhosphoSitePlus

  • See SLC22A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_004781.2  NP_695008.1  NP_695009.1  NP_695010.1  

    ENSEMBL proteins: 
     ENSP00000445946   ENSP00000353597   ENSP00000367102   ENSP00000396401   ENSP00000404441  
    Reactome Protein details: Q4U2R8

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for SLC22A6 (2 products) 

     
    antibodies-online peptides for SLC22A6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic anion transporter 1
    Organic anion transporters (OATs)

    4 InterPro protein domains:
     IPR004749 Orgcat_transp
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q4U2R8

    ProtoNet protein and cluster: Q4U2R8

    UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8
    Domain: Multiple cysteine residues are necessary for proper targeting to the plasma membrane (By similarity)
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22A6_HUMAN, Q4U2R8
    Function: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion
    exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of
    endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of
    2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of
    p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD),
    2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and
    3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine
    (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by
    p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen,
    glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC),
    S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol,
    phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin,
    bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate
    Biophysicochemical properties: Kinetic parameters: KM=9.3 uM for PAH (isoform 1); KM=4 uM for PAH (isoform 2);
    KM=11 uM for edaravone; KM=46 uM for cidofovir; KM=30 uM for adefovir; KM=5.77 uM for 2,4-D; KM=23.5 uM for HA;
    KM=14 uM for IA; KM=20.5 uM for IS; KM=141 uM for CMPF; Vmax=534 pmol/min/mg enzyme for 2,4-D uptake; Vmax=430
    pmol/min/mg enzyme for HA uptake; Vmax=110 pmol/min/mg enzyme for IA uptake; Vmax=216 pmol/min/mg enzyme for IS
    uptake; Vmax=801 pmol/min/mg enzyme for CMPF uptake;

         Genatlas biochemistry entry for SLC22A6:
    solute carrier protein family 22,member A6,polyspecific transporter for organic cations,mediating the coupled
    exchange of alpha-ketoglutarate with multiple organic ions,including p-aminohippurate (PAH),expressed strongly in
    kidney,weakly in brain

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005452inorganic anion exchanger activity IDA15037815
    GO:0005515protein binding IPI16189514
    GO:0008514organic anion transmembrane transporter activity IMP--
    GO:0015075ion transmembrane transporter activity ----
    GO:0015301anion:anion antiporter activity ----
         
    Find genes that share ontologies with SLC22A6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC22A6:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc22a6):
     hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 

    Find genes that share phenotypes with SLC22A6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC22A6

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SLC22A6:
    hsa-miR-204 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22A6_HUMAN, Q4U2R8: Cell membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA14749323
    GO:0005901caveola IEA--
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IDA15037815

    Find genes that share ontologies with SLC22A6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC22A6 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Organic anion transport0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Statin Pathway - Generalized, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics0.50
    Pravastatin Pathway, Pharmacokinetics0.00
    Ibuprofen Pathway, Pharmacokinetics0.50
    3Methotrexate Pathway, Pharmacokinetics
    Methotrexate Pathway (Brain Cell), Pharmacokinetics0.43
    Methotrexate Pathway, Pharmacokinetics0.43
    4Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    5Tenofovir/Adefovir Pathway, Pharmacokinetics
    Tenofovir/Adefovir Pathway, Pharmacokinetics


    Find genes that share SuperPaths with SLC22A6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC22A6
        Organic anion transport

    Selected PharmGKB Pathways for SLC22A6 (see all 7)
        Ibuprofen Pathway, Pharmacokinetics
    Methotrexate Pathway (Brain Cell), Pharmacokinetics
    Methotrexate Pathway, Pharmacokinetics
    Pravastatin Pathway, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC22A6: 
              Nephrotoxicity in human mouse rat
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC22A6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC22A6 (Q4U2R81, 2, 3 ENSP000003671024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926241, 2, 3, ENSP000000831824EBI-749741,EBI-743771 MINT-67592 I2D: score=5 STRING: ENSP00000083182
    SLC22A1ENSP000003559304STRING: ENSP00000355930
    SLC22A2ENSP000003559204STRING: ENSP00000355920
    SLC22A3ENSP000002753004STRING: ENSP00000275300
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006820anion transport ----
    GO:0015711organic anion transport IMP--
    GO:0015742alpha-ketoglutarate transport IDA9950961
    GO:0031427response to methotrexate IEA--
    GO:0034220ion transmembrane transport ----

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SLC22A6 (S22A6)

    2 HMDB Compounds for SLC22A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--

    Selected DrugBank Compounds for SLC22A6 (see all 110)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transportersubstrate inhibitor9880528 12837685 11408557 9950961 10929807 11602689 10703662 10991988 10336520 16434549 10462545 11815391 11669456 10594788 9228014 11641438 12538807 9374486 9887087 12472777
    Probenecid-- 57-66-9targetinhibitor15377641 11669456 11752352 11426832 12130730
    transporterinhibitor15377641 11669456 11752352 11426832 12130730 9880528 10991954 11408557 9950961 10929807 10336520 14978359 10049739 11669456 10594788 11099697 11426832 12130730 20460822 12472777
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor9880528 10991954 9950961 10220563 11669456 11099697 9887087 12130730 15716364
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate inhibitor9880528 9950961 9228014 12130730 20460822 9827570
    Penicillin G-- 61-33-6transporterinhibitor9950961 11669456 10411577 9887087 11861777 12130730
    Ketoprofen-- 22071-15-4transporterinhibitor10991954 10220563 10929807 11099697 12130730
    Piroxicam-- 36322-90-4transporterinhibitor10991954 10220563 10336520 11669456 12130730
    Salicyclic acid2-Carboxyphenol (see all 10)69-72-7transporterinhibitor10220563 10929807 10049739 11099697 12130730
    Cefacetrile7-Cyanacetylamino-cephalosporansaeure (see all 4)10206-21-0transportersubstrate inhibitor15618660 11909604 12005172 10411577
    CefazolinCefazolin sodium (see all 4)25953-19-9transportersubstrate inhibitor15618660 11909604 12005172 10411577

    Selected Novoseek inferred chemical compound relationships for SLC22A6 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutaric acid 90 2 10462545 (1), 18365245 (1)
    probenecid 86.1 12 10991954 (2), 15377641 (2), 15948029 (2), 18930752 (1) (see all 8)
    estrone sulfate 85.1 6 15377641 (1), 17674156 (1), 17639024 (1), 19394312 (1) (see all 5)
    indoxyl sulfate 77.2 5 14675047 (3), 19837111 (1)
    steviol 73.5 10 15644426 (4), 15948029 (3)
    p-aminohippuric acid 71.1 6 11744606 (2), 16038872 (1), 17312013 (1), 14737013 (1)
    adefovir 70 17 10462545 (4), 10991954 (3), 17372702 (2), 19001108 (1) (see all 6)
    cidofovir 68.8 13 10462545 (4), 17372702 (2), 19001108 (1), 17038320 (1) (see all 5)
    6-carboxyfluorescein 68.1 4 10929807 (2), 20237588 (1)
    dicarboxylate 66.3 3 10022228 (1), 12837685 (1), 15037815 (1)

    1 PharmGKB related drug/compound annotation for SLC22A6 gene    About this table
    Drug/compound PharmGKB Annotation
    dabrafenib



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A6 gene (5 alternative transcripts): 
    NM_004790.4  NM_153276.2  NM_153277.2  NM_153278.2  NM_153279.1  

    Unigene Cluster for SLC22A6:

    Solute carrier family 22 (organic anion transporter), member 6
    Hs.369252  [show with all ESTs]
    Unigene Representative Sequence: NM_004790
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540654 ENST00000360421(uc001nwl.3 uc001nwj.3) ENST00000377871(uc001nwk.3 uc001nwm.3)
    ENST00000458333 ENST00000421062 ENST00000537349
    miRNA
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    Additional mRNA sequence: 

    AB009697.1 AB009698.1 AF057039.2 AF097490.1 AF104038.1 AF124373.1 AJ251529.1 AJ271205.1 
    AK055764.1 AK091879.1 AK298374.1 BC033682.1 

    5 DOTS entries:

    DT.408377  DT.100751643  DT.91803256  DT.100021632  DT.120721226 

    Selected AceView cDNA sequences (see all 40):

    NM_153279 AB009698 NM_153278 AF124373 AI671740 AA351031 AF097490 BE222940 
    AB009697 NM_004790 BE048467 AW001738 AK055764 NM_153277 BC033682 AJ271205 
    BM725510 AJ251529 BX103715 NM_153276 AI017670 BI752244 AF057039 AK091879 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:                                                                          -               
    SP2:                                                                                          
    SP3:                                                              -           -               
    SP4:                                                              -                           


    ECgene alternative splicing isoforms for SLC22A6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCTCTTCA
    SLC22A6 Expression
    About this image


    SLC22A6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Proximal Tubule Cells Proximal Tubule
             Metanephros
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Eye (Sensory Organs)
             Retina
    SLC22A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369252

    UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8
    Tissue specificity: Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and
    placenta. Found at the basolateral membrane of the proximal tubule

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC22A6: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC22A6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a61 , 5 solute carrier family 22 (organic anion transporter), more1, 5 85.36(n)1
    86.21(a)1
      19 (5.44 cM)5
    183991  NM_008766.31  NP_032792.21 
     86179965 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    54(a)
    52(a)
    many ↔ many
    many ↔ many
    AAWZ02037376(2602-15801)
    GL344355.1(20356-33190)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.232852 Xenopus laevis, clone IMAGE4684003, mRNA 71.87(n)    BC042305.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oatx1 organic anion transporter X 53.81(n)
    48.2(a)
      555218  XM_001923093.4  XP_001923128.4 


    ENSEMBL Gene Tree for SLC22A6 (if available)
    TreeFam Gene Tree for SLC22A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A6 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  
    SLC22A132  SLC22A92  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A32  SLC22A252  
    Selected SIMAP similar genes for SLC22A6 using alignment to 2 protein entries:     S22A6_HUMAN (see all proteins) (see all similar genes):
    SLC22A8    SLC22A10    SLC22A20    SLC22A11    SLC22A12    UST6
    SLC22A24    SLC22A25    OAT7    SLC22A13    SLC22A9    SLC22A7
    SLC22A1    SLC22A14    SLC22A16    SLC22A2    SLC22A3    SLC22A4

    Find genes that share paralogs with SLC22A6           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SLC22A6
    PGOHUM00000258567 PGOHUM00000257893


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A6 (see all 257)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859454621,2
    --62744094(+) TAATGA/GTGTGG 4 -- ut310--------
    rs1915463291,2
    --62744136(+) CCTGGC/GAAGAT 4 -- ut310--------
    rs1812128221,2
    C--62744209(+) GTGGCC/TGGAGA 4 -- ut310--------
    rs1508112861,2
    C,F--62744220(+) CCTGTA/GGGACC 4 -- ut311Minor allele frequency- G:0.00--544
    rs1855764861,2
    C--62744339(+) GTCGCA/GTCTGT 8 T M mis10--------
    rs756472351,2
    C--62744362(+) CAGGGC/TGGCAG 4 -- int10--------
    rs3679645121,2
    C--62744399(+) TCCAGA/C/GCCAGG 4 -- int10--------
    rs1430410271,2
    --62744501(+) GATCCC/TCAGGA 4 -- int10--------
    rs724804161,2
    C--62744554(-) CCAAAG/ACTCTG 4 -- int16Minor allele frequency- A:0.00NS EU 779
    rs2013480521,2
    C--62744568(+) AGAAGA/GGGAAG 4 -- int11Minor allele frequency- G:0.00EU 1323

    HapMap Linkage Disequilibrium report for SLC22A6 (62703857 - 62752495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC22A6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34011CNV Loss18971310

    Human Gene Mutation Database (HGMD): SLC22A6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607582    OMIM disorders: --

    1 disease for SLC22A6:    
    About MalaCards
    bipolar i disorder

    1 disease from the University of Copenhagen DISEASES database for SLC22A6:
    Hyperuricemia

    Find genes that share disorders with SLC22A6           About GenesLikeMe

    3 Novoseek inferred disease relationships for SLC22A6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure acute 13.6 2 17312013 (1)
    immunodeficiency 7.4 5 15145940 (1), 19088254 (1)
    renal disease 1.61 1 14984259 (1)

    Genetic Association Database (GAD): SLC22A6
    Human Genome Epidemiology (HuGE) Navigator: SLC22A6 (5 documents)

    Export disorders for SLC22A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A6 gene, integrated from 10 sources (see all 170):
    (articles sorted by number of sources associating them with SLC22A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. (PubMed id 9950961)1, 2, 3, 7, 9 Lu R.... Schuster V.L. (Am. J. Physiol. 1999)
    2. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. (PubMed id 10462545)1, 2, 7, 9 Cihlar T....Sweet D.H. (Mol. Pharmacol. 1999)
    3. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. (PubMed id 9887087)1, 2, 7, 9 Hosoyamada M.... Endou H. (Am. J. Physiol. 1999)
    4. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PubMed id 10049739)1, 2, 7, 9 Race J.E.... Holtzman E.J. (Biochem. Biophys. Res. Commun. 1999)
    5. Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). (PubMed id 15914676)1, 2, 4, 9 Bleasby K.... Pritchard J.B. (J. Pharmacol. Exp. Ther. 2005)
    6. Cloning of a human renal p-aminohippurate transporter, hROAT1. (PubMed id 9762842)1, 2, 3 Reid G.... Burckhardt G. (Kidney Blood Press. Res. 1998)
    7. Urate transport via human PAH transporter hOAT1 and its gene structure. (PubMed id 12472777)1, 7, 9 Ichida K....Endou H. (Kidney Int. 2003)
    8. Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. (PubMed id 15145940)1, 2, 9 Hong M.... You G. (J. Biol. Chem. 2004)
    9. A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. (PubMed id 17038320)1, 2, 9 Perry J.L.... Pritchard J.B. (J. Biol. Chem. 2006)
    10. Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. (PubMed id 10964714)1, 2, 9 Bahn A.... Burckhardt G. (Biochem. Biophys. Res. Commun. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9356 HGNC: 10970 AceView: SLC22A6 Ensembl:ENSG00000197901 euGenes: HUgn9356
    ECgene: SLC22A6 H-InvDB: SLC22A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A6 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/slc22a6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A6 gene:
    Search GeneIP for patents involving SLC22A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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