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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC22A6 Gene

protein-coding   GIFtS: 64
GCID: GC11M062744

solute carrier family 22 (organic anion transporter), member...
 Explore 8 diseases affiliated with
SLC22A6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC22A6    

Aliases
for SLC22A6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 22 (Organic Anion Transporter), Member 61 2     HROAT11
OAT11 2 3 5     PAH Transporter2 3
PAHT1 2 3 5     HOAT12
ROAT11 2     Para-Aminohippurate Transporter2
Organic Anion Transporter 12 3     Solute Carrier Family 22 Member 62
Renal Organic Anion Transporter 12 3     HOAT12
HPAHT1     

External Ids:    HGNC: 109701   Entrez Gene: 93562   Ensembl: ENSG000001979017   OMIM: 6075825   UniProtKB: Q4U2R83   

Export aliases for SLC22A6 gene to outside databases

Previous GC identifers: GC11M065256 GC11M064319 GC11M062994 GC11M062519 GC11M062500 GC11M059073


Summaries
for SLC22A6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC22A6:
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of
which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the
basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8
Function: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion
exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous
dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of
2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of
p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD),
2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and
3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine
(PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by
p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and
okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine
(CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate
(PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol
red, urate, and alpha-ketoglutarate

Gene Wiki entry for SLC22A6 (Organic anion transporter 1)


Genomic Views
for SLC22A6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC22A6 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC22A6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC22A6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

SLC22A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062744:  view genomic region     (about GC identifiers)

Start:
 62,703,857 bp from pter      End:
 62,752,469 bp from pter
Size:
 48,613 bases      Orientation:
 minus strand

Proteins
for SLC22A6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8 (See protein sequence)
Recommended Name: Solute carrier family 22 member 6  
Size: 563 amino acids; 61816 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8MY93 B2D0R6 O95187 O95742 Q7LDA0 Q8N192 Q9NQA6 Q9NQC2 Q9UBG6 Q9UEQ8
Alternative splicing: 4 isoforms:  Q4U2R8-1   Q4U2R8-2   Q4U2R8-3   Q4U2R8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC22A6: NX_Q4U2R8

Post-translational modifications:

  • Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting
    • of the transporter to the plasma membrane1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q4U2R8

    • SLC22A6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_004781.2  NP_695008.1  NP_695009.1  NP_695010.1  

    ENSEMBL proteins: 
     ENSP00000445946   ENSP00000353597   ENSP00000367102   ENSP00000396401   ENSP00000404441  
    Reactome Protein details: Q4U2R8
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC22A6

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA14749323
    GO:0005901caveola IEA--
    GO:0016323basolateral plasma membrane IDA9887087


    SLC22A6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC22A6

    Protein Domains /
    Families
    for SLC22A6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC22A6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR004749 Orgcat_transp
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q4U2R8

    ProtoNet protein and cluster: Q4U2R8

    UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8
    Domain: Multiple cysteine residues are necessary for proper targeting to the plasma membrane (By similarity)
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family


    Function
    for SLC22A6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8
    Function: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion
    exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous
    dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of
    2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of
    p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD),
    2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and
    3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine
    (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by
    p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and
    okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine
    (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate
    (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol
    red, urate, and alpha-ketoglutarate
    Biophysicochemical properties: Kinetic parameters: KM=9.3 uM for PAH (isoform 1); KM=4 uM for PAH (isoform 2); KM=11 uM
    for edaravone; KM=46 uM for cidofovir; KM=30 uM for adefovir; KM=5.77 uM for 2,4-D; KM=23.5 uM for HA; KM=14 uM for
    IA; KM=20.5 uM for IS; KM=141 uM for CMPF; Vmax=534 pmol/min/mg enzyme for 2,4-D uptake; Vmax=430 pmol/min/mg enzyme
    for HA uptake; Vmax=110 pmol/min/mg enzyme for IA uptake; Vmax=216 pmol/min/mg enzyme for IS uptake; Vmax=801
    pmol/min/mg enzyme for CMPF uptake;

         Genatlas biochemistry entry for SLC22A6:
    solute carrier protein family 22,member A6,polyspecific transporter for organic cations,mediating the coupled exchange
    of alpha-ketoglutarate with multiple organic ions,including p-aminohippurate (PAH),expressed strongly in kidney,weakly
    in brain

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    SwitchGear 3'UTR luciferase reporter plasmid: SLC22A6 3' UTR sequence
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005452inorganic anion exchanger activity IDA15037815
    GO:0005515protein binding IPI19060904
    GO:0008514organic anion transmembrane transporter activity IMP--
    GO:0015347sodium-independent organic anion transmembrane transporter activity IEA--


    SLC22A6 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SLC22A6:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc22a6):
     hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 

    SLC22A6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC22A6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Pravastatin Pathway, Pharmacokinetics
    		Pravastatin Pathway, Pharmacokinetics1.00
    		Methotrexate Pathway (Brain Cell), Pharmacokinetics0.33
    		Methotrexate Pathway, Pharmacokinetics0.47
    3Organic cation/anion/zwitterion transport
    		Organic cation/anion/zwitterion transport1.00
    		Organic anion transport0.38
    4Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    		Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics1.00
    5Tenofovir/Adefovir Pathway, Pharmacokinetics
    		Tenofovir/Adefovir Pathway, Pharmacokinetics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SLC22A6
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Organic cation/anion/zwitterion transport
    Organic anion transport

    5/7 PharmGKB Pathways for SLC22A6 (see all 7)
        Methotrexate Pathway (Brain Cell), Pharmacokinetics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics
    Methotrexate Pathway, Pharmacokinetics
    Pravastatin Pathway, Pharmacokinetics
    Statin Pathway - Generalized, Pharmacokinetics


    SLC22A6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC22A6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC22A6 (Q4U2R81, 2, 3 ENSP000003671024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926241, 2, 3, ENSP000000831824EBI-749741,EBI-743771 MINT-67592 I2D: score=5 STRING: ENSP00000083182
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006820anion transport ----
    GO:0015711organic anion transport IMP--
    GO:0015742alpha-ketoglutarate transport IDA9950961
    GO:0031427response to methotrexate IEA--
    GO:0043252sodium-independent organic anion transport IEA--


    SLC22A6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC22A6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC22A6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC22A6

    2 HMDB Compounds for SLC22A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    SodiumSodium (see all 2)7440-23-5--

    10/101 DrugBank Compounds for SLC22A6 (see all 101)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ProbenecidProbenecid Acid (see all 2)57-66-9targetinhibitor15377641 11669456 11752352 11426832 12130730
    transporterinhibitor15377641 11669456 11752352 11426832 12130730 9880528 10991954 11408557 9950961 10929807 10336520 14978359 10049739 11669456 10594788 11099697 11426832 12130730 20460822 12472777
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transportersubstrate inhibitor9880528 12837685 11408557 9950961 10929807 11602689 10703662 10991988 10336520 10462545 11815391 11669456 10594788 9228014 11641438 12538807 9374486 9887087 12472777
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor9880528 10991954 9950961 10220563 11669456 11099697 9887087 12130730 15716364
    MethotrexateAmethopterin (see all 12)59-05-2transportersubstrate inhibitor9880528 9950961 9228014 12130730 20460822 9827570
    Penicillin G-- 61-33-6transporterinhibitor9950961 11669456 10411577 9887087 11861777 12130730
    Ketoprofen-- 22071-15-4transporterinhibitor10991954 10220563 10929807 11099697 12130730
    Piroxicam-- 36322-90-4transporterinhibitor10991954 10220563 10336520 11669456 12130730
    Salicyclic acid2-Carboxyphenol (see all 10)69-72-7transporterinhibitor10220563 10929807 10049739 11099697 12130730
    Cefacetrile7-Cyanacetylamino-cephalosporansaeure (see all 4)10206-21-0transportersubstrate inhibitor15618660 11909604 12005172 10411577
    CefazolinCefazolin sodium (see all 4)25953-19-9transportersubstrate inhibitor15618660 11909604 12005172 10411577

    10/49 Novoseek chemical compound relationships for SLC22A6 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutaric acid 90 2 10462545 (1), 18365245 (1)
    probenecid 86.1 12 10991954 (2), 15377641 (2), 15948029 (2), 18930752 (1) (see all 8)
    estrone sulfate 85.1 6 15377641 (1), 17674156 (1), 17639024 (1), 19394312 (1) (see all 5)
    indoxyl sulfate 77.2 5 14675047 (3), 19837111 (1)
    steviol 73.5 10 15644426 (4), 15948029 (3)
    p-aminohippuric acid 71.1 6 11744606 (2), 16038872 (1), 17312013 (1), 14737013 (1)
    adefovir 70 17 10462545 (4), 10991954 (3), 17372702 (2), 19001108 (1) (see all 6)
    cidofovir 68.8 13 10462545 (4), 17372702 (2), 19001108 (1), 17038320 (1) (see all 5)
    6-carboxyfluorescein 68.1 4 10929807 (2), 20237588 (1)
    dicarboxylate 66.3 3 10022228 (1), 12837685 (1), 15037815 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC22A6 / S22A6 

    Transcripts
    for SLC22A6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC22A6 gene (5 alternative transcripts): 
    NM_004790.4  NM_153276.2  NM_153277.2  NM_153278.2  NM_153279.1  

    Unigene Cluster for SLC22A6:

    Solute carrier family 22 (organic anion transporter), member 6
    Hs.369252  [show with all ESTs]
    Unigene Representative Sequence: NM_004790
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540654 ENST00000360421(uc001nwl.3 uc001nwj.3) ENST00000377871(uc001nwk.3 uc001nwm.3)
    ENST00000458333 ENST00000421062 ENST00000537349

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB009697.1 AB009698.1 AF057039.2 AF097490.1 AF104038.1 AF124373.1 AJ251529.1 AJ271205.1 
    AK055764.1 AK091879.1 AK298374.1 BC033682.1 

    5 DOTS entries:

    DT.408377  DT.100751643  DT.91803256  DT.100021632  DT.120721226 

    24/40 AceView cDNA sequences (see all 40):

    NM_004790 AB009698 AK055764 AI671740 AF097490 NM_153277 NM_153279 BE048467 
    AB009697 AJ251529 AF124373 BC033682 BM725510 AJ271205 AA351031 NM_153278 
    NM_153276 BE222940 BX103715 AW001738 BM678141 AI017670 AW242860 BI761774 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:                                                                          -               
    SP2:                                                                                          
    SP3:                                                              -           -               
    SP4:                                                              -                           


    ECgene alternative splicing isoforms for SLC22A6

    Expression
    for SLC22A6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC22A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCTCTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC22A6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyEpithelial TubuleKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC22A6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC22A6

    SOURCE GeneReport for Unigene cluster: Hs.369252

    UniProtKB/Swiss-Prot: S22A6_HUMAN, Q4U2R8
    Tissue specificity: Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta.
    Found at the basolateral membrane of the proximal tubule

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC22A6: 
              Nephrotoxicity in human mouse rat
              Drug Transporters in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for SLC22A6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A6 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 4)    		 --
    		 56(a)
    55(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 AAWZ02037376(3916-15587)
    AAWZ02038813(6-2374)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.232852 Xenopus laevis, clone IMAGE4684003, mRNA 71.87(n)    BC042305.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii oat1 organic anion transporter 57.45(n)
    52.52(a)    		   404609  NM_207077.1  NP_996960.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG37903 carnitine transporter 30(a)
    (best of 13)    		   49D6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK455.8a3 membrane transporter 28(a)
    (best of 5)    		   X(11381686-11385364)   --


    ENSEMBL Gene Tree for SLC22A6 (if available)
    TreeFam Gene Tree for SLC22A6 (if available) 

    Paralogs
    for SLC22A6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC22A6 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A92  SLC22A22  
    SLC22A102  SLC22A132  SLC22A152  SLC22A72  SLC22A122  SLC22A32  SLC22A162  SLC22A252  
    18/19 SIMAP similar genes for SLC22A6 using alignment to 2 protein entries:     S22A6_HUMAN (see all proteins) (see all similar genes):
    SLC22A8    SLC22A10    SLC22A20    SLC22A11    SLC22A12    SLC22A24
    UST6    SLC22A25    OAT7    SLC22A13    SLC22A9    SLC22A7
    SLC22A14    SLC22A1    SLC22A16    SLC22A2    SLC22A3    SLC22A4

    SLC22A6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SLC22A6
    PGOHUM00000258567 PGOHUM00000257893


    Genomic Variants
    for SLC22A6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in SLC22A6 are shown (see all 185)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1859454621,2
    		--62744094(+) TAATGA/GTGTGG 4 -- ut310--------
    rs1915463291,2
    		--62744136(+) CCTGGC/GAAGAT 4 -- ut310--------
    rs1812128221,2
    		--62744209(+) GTGGCC/TGGAGA 4 -- ut310--------
    rs1508112861,2
    		C,F,--62744220(+) CCTGTA/GGGACC 4 -- ut311Minor allele frequency- G:0.00--544
    rs1855764861,2
    		C,--62744339(+) GTCGCA/GTCTGT 8 T M mis10--------
    rs756472351,2
    		C,--62744362(+) CAGGGC/TGGCAG 4 -- int10--------
    rs1430410271,2
    		--62744501(+) GATCCC/TCAGGA 4 -- int10--------
    rs724804161,2
    		C--62744554(-) CCAAAG/ACTCTG 4 -- int16Minor allele frequency- A:0.00NS EU 779
    rs115686351,2
    		C,F,H,--62744751(-) ATCTAC/TGGTGC 6 Y int1 syn115Minor allele frequency- T:0.01NS NA WA 6262
    rs2007935071,2
    		C,--62744798(+) GCTCAA/CCAGTG 6 V L int1 mis10--------

    HapMap Linkage Disequilibrium report for SLC22A6 (62703857 - 62752469 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLC22A6
         1 CNV: 47961
    Human Gene Mutation Database (HGMD): SLC22A6

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    Disorders / Diseases
    for SLC22A6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC22A6 for disorders           About GeneDecksing

    OMIM gene information: 607582    OMIM disorders: --

    8 diseases for SLC22A6:    About MalaCards
    bipolar i disorder    cholestasis    homocysteine    choroiditis
    influenza    immunodeficiency    ischemia    hypertension

    1 disease from the University of Copenhagen DISEASES database for SLC22A6:
    Hyperuricemia

    3 Novoseek disease relationships for SLC22A6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure acute 13.6 2 17312013 (1)
    immunodeficiency 7.4 5 15145940 (1), 19088254 (1)
    renal disease 1.61 1 14984259 (1)

    Genetic Association Database (GAD): SLC22A6
    Human Genome Epidemiology (HuGE) Navigator: SLC22A6 (5 documents)

    Export disorders for SLC22A6 gene to outside databases

    Publications
    for SLC22A6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC22A6 gene, integrated from 9 sources (see all 163):
    (articles sorted by number of sources associating them with SLC22A6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. (PubMed id 9950961)1, 2, 3, 7, 9 Lu R.... Schuster V.L. (1999)
    2. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. (PubMed id 10462545)1, 2, 7, 9 Cihlar T....Sweet D.H. (1999)
    3. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. (PubMed id 9887087)1, 2, 7, 9 Hosoyamada M....Endou H. (1999)
    4. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). (PubMed id 10049739)1, 2, 7, 9 Race J.E.... Holtzman E.J. (1999)
    5. Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). (PubMed id 15914676)1, 2, 4, 9 Bleasby K....Pritchard J.B. (2005)
    6. Cloning of a human renal p-aminohippurate transporter, hROAT1. (PubMed id 9762842)1, 2, 3 Reid G.... Burckhardt G. (1998)
    7. Urate transport via human PAH transporter hOAT1 and its gene structure. (PubMed id 12472777)1, 7, 9 Ichida K....Endou H. (2003)
    8. Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. (PubMed id 15145940)1, 2, 9 Hong M.... You G. (2004)
    9. A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. (PubMed id 17038320)1, 2, 9 Perry J.L.... Pritchard J.B. (2006)
    10. Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. (PubMed id 10964714)1, 2, 9 Bahn A.... Burckhardt G. (2000)

    External Searches for SLC22A6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC22A6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9356 HGNC: 10970 AceView: SLC22A6 Ensembl:ENSG00000197901 euGenes: HUgn9356
    ECgene: SLC22A6 H-InvDB: SLC22A6

    Other Databases showing SLC22A6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC22A6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC22A6 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/slc22a6/

    Intellectual Property
    for SLC22A6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC22A6 gene:
    Search GeneIP for patents involving SLC22A6

    GeneCards and IP:
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