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Aliases for SLC22A4 Gene

Aliases for SLC22A4 Gene

  • Solute Carrier Family 22 Member 4 2 3
  • Solute Carrier Family 22 (Organic Cation/Zwitterion Transporter), Member 4 2 3 5
  • Solute Carrier Family 22 (Organic Cation/Ergothioneine Transporter), Member 4 2 3
  • Organic Cation/Carnitine Transporter 1 3 4
  • Ergothioneine Transporter 3 4
  • ET Transporter 3 4
  • OCTN1 3 4
  • Integral Membrane Transport Protein 3
  • UT2H 4
  • ETT 4

External Ids for SLC22A4 Gene

Previous GeneCards Identifiers for SLC22A4 Gene

  • GC05P131152
  • GC05P132077
  • GC05P131660
  • GC05P131706
  • GC05P131658
  • GC05P126822

Summaries for SLC22A4 Gene

Entrez Gene Summary for SLC22A4 Gene

  • Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A4 Gene

SLC22A4 (Solute Carrier Family 22 Member 4) is a Protein Coding gene. Diseases associated with SLC22A4 include Rheumatoid Arthritis and Tracheal Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Phospholipase D signaling pathway. GO annotations related to this gene include nucleotide binding and transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A4 Gene

  • Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).

Gene Wiki entry for SLC22A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A4 Gene

Genomics for SLC22A4 Gene

Regulatory Elements for SLC22A4 Gene

Enhancers for SLC22A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC22A4 on UCSC Golden Path with GeneCards custom track

Promoters for SLC22A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC22A4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SLC22A4 gene promoter:

Genomic Location for SLC22A4 Gene

Chromosome:
5
Start:
132,294,384 bp from pter
End:
132,344,206 bp from pter
Size:
49,823 bases
Orientation:
Plus strand

Genomic View for SLC22A4 Gene

Genes around SLC22A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A4 Gene

Proteins for SLC22A4 Gene

  • Protein details for SLC22A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H015-S22A4_HUMAN
    Recommended name:
    Solute carrier family 22 member 4
    Protein Accession:
    Q9H015
    Secondary Accessions:
    • O14546

    Protein attributes for SLC22A4 Gene

    Size:
    551 amino acids
    Molecular mass:
    62155 Da
    Quaternary structure:
    • Interacts with PDZK1.

neXtProt entry for SLC22A4 Gene

Proteomics data for SLC22A4 Gene at MOPED

Post-translational modifications for SLC22A4 Gene

  • Glycosylation at Asn 57, Asn 64, and Asn 91
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A4 Gene

Domains & Families for SLC22A4 Gene

Gene Families for SLC22A4 Gene

Protein Domains for SLC22A4 Gene

Suggested Antigen Peptide Sequences for SLC22A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H015

UniProtKB/Swiss-Prot:

S22A4_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A4: view

Function for SLC22A4 Gene

Molecular function for SLC22A4 Gene

GENATLAS Biochemistry:
solute carrier family 22,member A4,polyspecific transporter of organic cations,strongly expressed in kidney
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.470 mM for TEA (at 37 degrees Celsius and pH 7.4) {ECO:0000269 PubMed:15459889, ECO:0000269 PubMed:9426230}; Vmax=0.974 nmol/min/mg enzyme toward TEA (at 37 degrees Celsius and pH 7.4) {ECO:0000269 PubMed:15459889, ECO:0000269 PubMed:9426230}; pH dependence: More active at neutral and alkaline pHs than at acidic pHs. {ECO:0000269 PubMed:15459889, ECO:0000269 PubMed:9426230};
UniProtKB/Swiss-Prot Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
UniProtKB/Swiss-Prot Induction:
Overexpressed upon TNF treatment.

Gene Ontology (GO) - Molecular Function for SLC22A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008513 secondary active organic cation transmembrane transporter activity TAS --
GO:0015491 cation:cation antiporter activity IDA 9426230
GO:0015651 quaternary ammonium group transmembrane transporter activity IDA 9426230
genes like me logo Genes that share ontologies with SLC22A4: view
genes like me logo Genes that share phenotypes with SLC22A4: view

Animal Models for SLC22A4 Gene

MGI Knock Outs for SLC22A4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A4

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A4 Gene

Localization for SLC22A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A4 Gene COMPARTMENTS Subcellular localization image for SLC22A4 gene
Compartment Confidence
mitochondrion 5
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC22A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SLC22A4: view

Pathways & Interactions for SLC22A4 Gene

genes like me logo Genes that share pathways with SLC22A4: view

Interacting Proteins for SLC22A4 Gene

Gene Ontology (GO) - Biological Process for SLC22A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009437 carnitine metabolic process IEA,IBA --
GO:0015695 organic cation transport TAS 9426230
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A4: view

No data available for SIGNOR curated interactions for SLC22A4 Gene

Drugs & Compounds for SLC22A4 Gene

(34) Drugs for SLC22A4 Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desipramine Approved Pharma Transporter, inhibitor 39
Quinidine Approved Pharma Pore Blocker, Transporter, inhibitor 43
Amiloride Approved Pharma Channel blocker, Transporter, inhibitor 47
Cimetidine Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor H2 receptor antagonist, H2 antagonist, I1 agonist 68
Guanidine Approved Pharma Transporter, inhibitor 0

(7) Additional Compounds for SLC22A4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ergothioneine
  • Ergothionine
  • L-Ergothioneine
  • L-Thioneine
  • Sympectothion
  • Thiolhistidine-betaine
497-30-3
sodium
  • Sodium
  • Sodium ion
7440-23-5
O-Desmethylverapamil (D-702)
genes like me logo Genes that share compounds with SLC22A4: view

Transcripts for SLC22A4 Gene

mRNA/cDNA for SLC22A4 Gene

Unigene Clusters for SLC22A4 Gene

Solute carrier family 22 (organic cation/ergothioneine transporter), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A4 Gene

No ASD Table

Relevant External Links for SLC22A4 Gene

GeneLoc Exon Structure for
SLC22A4
ECgene alternative splicing isoforms for
SLC22A4

Expression for SLC22A4 Gene

mRNA expression in normal human tissues for SLC22A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A4 Gene

This gene is overexpressed in Whole Blood (x23.9).

Protein differential expression in normal tissues from HIPED for SLC22A4 Gene

This gene is overexpressed in Nasal epithelium (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A4 Gene



SOURCE GeneReport for Unigene cluster for SLC22A4 Gene Hs.310591

mRNA Expression by UniProt/SwissProt for SLC22A4 Gene

Q9H015-S22A4_HUMAN
Tissue specificity: Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells.
genes like me logo Genes that share expression patterns with SLC22A4: view

Protein tissue co-expression partners for SLC22A4 Gene

Primer Products

Orthologs for SLC22A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC22A4 35
  • 89.96 (n)
  • 86.93 (a)
bta-mir-2457 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A4 35
  • 91.6 (n)
  • 90.74 (a)
SLC22A4 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a4 35
  • 86.93 (n)
  • 85.12 (a)
Slc22a4 16
Slc22a4 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC22A4 35
  • 99.64 (n)
  • 99.09 (a)
SLC22A4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a4 35
  • 86.09 (n)
  • 85.66 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC22A4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A4 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A4 35
  • 78.02 (n)
  • 77.23 (a)
SLC22A4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A4 36
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100000685 35
  • 56.78 (n)
  • 48.88 (a)
slc22a21 36
  • 59 (a)
ManyToMany
slc22a4 36
  • 49 (a)
ManyToMany
slc22a5 36
  • 48 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13517 35
fruit fly
(Drosophila melanogaster)
Insecta CG13610 37
  • 33 (a)
CG14857 37
  • 25 (a)
CG16727 37
  • 27 (a)
CG17751 37
  • 26 (a)
CG17752 37
  • 26 (a)
CG3790 37
  • 31 (a)
CG4630 37
  • 32 (a)
CG5592 37
  • 25 (a)
CG6126 37
  • 27 (a)
CG6231 37
  • 24 (a)
CG6356 37
  • 28 (a)
CG6600 37
  • 30 (a)
CG7084 37
  • 28 (a)
CG7333 37
  • 26 (a)
CG7442 37
  • 26 (a)
CG7458 37
  • 27 (a)
CG9317 37
  • 29 (a)
Orct 37
  • 36 (a)
CG8654 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea B0252.3 37
  • 27 (a)
F52F12.1a 37
  • 30 (a)
K05F1.6 37
  • 26 (a)
oct-1 37
  • 30 (a)
Y82E9BR.16 37
  • 26 (a)
ZK455.8a 37
  • 27 (a)
ZK455.8b 37
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for SLC22A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A4 Gene

ENSEMBL:
Gene Tree for SLC22A4 (if available)
TreeFam:
Gene Tree for SLC22A4 (if available)

Paralogs for SLC22A4 Gene

(13) SIMAP similar genes for SLC22A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC22A4: view

Variants for SLC22A4 Gene

Sequence variations from dbSNP and Humsavar for SLC22A4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_019528 -
VAR_019529 -
VAR_019530 -
rs2631358 -- 132,305,848(-) ttata(G/T)ttttt intron-variant
rs162887 -- 132,293,472(-) GGCTG(C/T)CAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC22A4 Gene

Variant ID Type Subtype PubMed ID
nsv882890 CNV Loss 21882294
dgv6327n71 CNV Loss 21882294
dgv6328n71 CNV Loss 21882294
dgv6329n71 CNV Loss 21882294
nsv882898 CNV Loss 21882294
dgv6330n71 CNV Loss 21882294
dgv6331n71 CNV Loss 21882294
nsv882902 CNV Loss 21882294
nsv882903 CNV Loss 21882294
nsv882904 CNV Loss 21882294

Variation tolerance for SLC22A4 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A4 Gene

Human Gene Mutation Database (HGMD)
SLC22A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A4 Gene

Disorders for SLC22A4 Gene

MalaCards: The human disease database

(9) MalaCards diseases for SLC22A4 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • rheumatoid arthritis, progression of
tracheal disease
  • tracheal diseases
crohn's disease
  • ileitis
tracheomalacia
  • congenital tracheomalacia
epithelioid trophoblastic tumor
  • trophoblastic tumor, epithelioid
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

S22A4_HUMAN
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:14608356}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for SLC22A4

Genetic Association Database (GAD)
SLC22A4
Human Genome Epidemiology (HuGE) Navigator
SLC22A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A4
genes like me logo Genes that share disorders with SLC22A4: view

No data available for Genatlas for SLC22A4 Gene

Publications for SLC22A4 Gene

  1. Discovery of the ergothioneine transporter. (PMID: 15795384) Gruendemann D. … Schoemig E. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 23 67
  2. Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. (PMID: 20020740) Nakamura T. … Tamai I. (Mol. Pharm. 2010) 3 23 25 26
  3. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. (PMID: 19536068) Tzvetkov M.V. … BrockmAPller J. (Clin. Pharmacol. Ther. 2009) 3 23 25 26
  4. Epitope shared by functional variant of organic cation/carnitine transporter, OCTN1, Campylobacter jejuni and Mycobacterium paratuberculosis may underlie susceptibility to Crohn's disease at 5q31. (PMID: 16246312) Lamhonwah A.M. … Tein I. (Biochem. Biophys. Res. Commun. 2005) 3 25 26
  5. Functional domains in the carnitine transporter OCTN2, defective in primary carnitine deficiency. (PMID: 14506273) Amat di San Filippo C. … Longo N. (J. Biol. Chem. 2003) 23 25 26

Products for SLC22A4 Gene

Sources for SLC22A4 Gene

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