Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC22A4 Gene

protein-coding   GIFtS: 62
GCID: GC05P131658

Solute Carrier Family 22 (Organic Cation/Zwitterion Transporter),...

(Previous names: solute carrier family 22 (organic cation/ergothioneine transporter),...)
  See SLC22A4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 22 (Organic Cation/Zwitterion Transporter),
Member 41 2
     ET Transporter2 3
OCTN12 3 5     Integral Membrane Transport Protein2
Solute Carrier Family 22 (Organic Cation/Ergothioneine Transporter),
Member 41 2
     Solute Carrier Family 22 Member 42
Ergothioneine Transporter2 3     ETT3
Organic Cation/Carnitine Transporter 12 3     UT2H3

External Ids:    HGNC: 109681   Entrez Gene: 65832   Ensembl: ENSG000001972087   OMIM: 6041905   UniProtKB: Q9H0153   

Export aliases for SLC22A4 gene to outside databases

Previous GC identifers: GC05P131152 GC05P132077 GC05P131660 GC05P131706 GC05P126822


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC22A4 Gene:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for
elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins.
The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven
putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least
partially ATP-dependent. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC22A4 Gene:
SLC22A4 (solute carrier family 22 (organic cation/zwitterion transporter), member 4) is a protein-coding gene. Diseases associated with SLC22A4 include rheumatoid arthritis. GO annotations related to this gene include symporter activity and nucleotide binding. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22A4_HUMAN, Q9H015
Function: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one
molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement
of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems
to be ergothioneine (ET)

Gene Wiki entry for SLC22A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A4 promoter sequence
   Search Chromatin IP Primers for SLC22A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23.3

SLC22A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P131658:  view genomic region     (about GC identifiers)

Start:
131,630,136 bp from pter      End:
131,679,899 bp from pter
Size:
49,764 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S22A4_HUMAN, Q9H015 (See protein sequence)
Recommended Name: Solute carrier family 22 member 4  
Size: 551 amino acids; 62155 Da
Subunit: Interacts with PDZK1 (By similarity)
Caution: PubMed:9426230 reported that this protein does not transport carnitine, however, experiments were done
with the Phe-503 variant, which affects the ability to transport carnitine. PubMed:15459889 showed that, although
weakly, it can also transport carnitine at some level. Its function in carnitine transport is therefore unclear
Secondary accessions: O14546

Explore the universe of human proteins at neXtProt for SLC22A4: NX_Q9H015

Explore proteomics data for SLC22A4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn64, Asn91
  • Modification sites at PhosphoSitePlus

  • See SLC22A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003050.2  
    ENSEMBL proteins: 
     ENSP00000200652  
    Reactome Protein details: Q9H015

    SLC22A4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC22A4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC22A4
    GenScript Custom Purified and Recombinant Proteins Services for SLC22A4
    Novus Biologicals SLC22A4 Protein
    Novus Biologicals SLC22A4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC22A4 

    SLC22A4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC22A4
    Novus Biologicals SLC22A4 Antibodies
    Abcam antibodies for SLC22A4
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SLC22A4
    LSBio Antibodies in human, mouse, rat for SLC22A4

    SLC22A4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC22A4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC22A4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC22A4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic cation/carnitine transporter 1
    Organic zwitterions/cation transporters (OCTN)

    5 InterPro protein domains:
     IPR004749 Orgcat_transp
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9H015

    ProtoNet protein and cluster: Q9H015

    UniProtKB/Swiss-Prot: S22A4_HUMAN, Q9H015
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22A4_HUMAN, Q9H015
    Function: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one
    molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement
    of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems
    to be ergothioneine (ET)
    Biophysicochemical properties: Kinetic parameters: KM=0.470 mM for TEA (at 37 degrees Celsius and pH 7.4);
    Vmax=0.974 nmol/min/mg enzyme toward TEA (at 37 degrees Celsius and pH 7.4); pH dependence: More active at
    neutral and alkaline pHs than at acidic pHs;
    Induction: Overexpressed upon TNF treatment

         Genatlas biochemistry entry for SLC22A4:
    solute carrier family 22,member A4,polyspecific transporter of organic cations,strongly expressed in kidney

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS9426230
    GO:0005515protein binding IPI15523054
    GO:0005524ATP binding IEA--
    GO:0008513secondary active organic cation transmembrane transporter activity TAS9426230
    GO:0015075ion transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC22A4           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc22a4):
     digestive/alimentary  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with SLC22A4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc22a4tm1Atsu for SLC22A4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC22A4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC22A4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC22A4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC22A4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SLC22A4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC22A4
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC22A4
    Predesigned siRNA for gene silencing in human, mouse, rat SLC22A4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC22A4

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC22A4 (see all 7)
    OriGene ORF clones in mouse, rat for SLC22A4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC22A4 (NM_003059)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC22A4
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC22A4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    S22A4_HUMAN, Q9H015: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane4
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA16729965
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9426230
    GO:0016021integral component of membrane ----
    GO:0016324apical plasma membrane IDA18641280

    Find genes that share ontologies with SLC22A4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC22A4 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Organic cation transport0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38


    Find genes that share SuperPaths with SLC22A4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC22A4
        Organic cation transport


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A4
    Interactions:

        GeneGlobe Interaction Network for SLC22A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SLC22A4 (Q9H0153 ENSP000002006524) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    PDZK1Q5T2W13, ENSP000003421434I2D: score=2 STRING: ENSP00000342143
    SLC9A3R2Q155993, ENSP000004080054I2D: score=1 STRING: ENSP00000408005
    PDZD3ENSP000003271074STRING: ENSP00000327107
    ATG4AENSP000003613064STRING: ENSP00000361306
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006641triglyceride metabolic process IEA--
    GO:0006814sodium ion transport IEA--
    GO:0007589body fluid secretion TAS9426230
    GO:0009437carnitine metabolic process IEA--
    GO:0015695organic cation transport TAS9426230

    Find genes that share ontologies with SLC22A4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A4 (S22A4)

    3 HMDB Compounds for SLC22A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ErgothioneineErgothionine (see all 5)497-30-3--
    L-Carnitine(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate (see all 33)541-15-1--
    SodiumSodium (see all 2)7440-23-5--

    Selected DrugBank Compounds for SLC22A4 (see all 27)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Carnitine(-)-Carnitine (see all 6)541-15-1target--14506273 12181285 16997449 16246312
    transportersubstrate inhibitor14506273 12181285 16997449 16246312 11010964 10215651
    Cimetidine-- 51481-61-9transporterinhibitor10825452 10215651
    NicotineL-Nicotine (see all 2)54-11-5transporterinhibitor10825452 10215651
    Procainamide-- 51-06-9transporterinhibitor10825452 10215651
    VerapamilVerapamil [Usan:Ban:Inn] (see all 4)52-53-9transporterinhibitor10825452 10215651
    AmilorideAmilorida [INN-Spanish] (see all 6)2016-88-8transporterinhibitor10825452
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transporterinhibitor10215651
    CholineBilineurine (see all 7)62-49-7transporterinhibitor10215651
    ClonidineChlornidinum (see all 6)4205-90-7transporterinhibitor10215651
    DesipramineDemethylimipramine (see all 11)50-47-5transporterinhibitor10825452

    Selected Novoseek inferred chemical compound relationships for SLC22A4 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ergothioneine 93.8 34 17532304 (7), 17086603 (4), 18670092 (3), 15795384 (3) (see all 8)
    moxa 80.8 2 15028572 (1), 11414662 (1)
    carnitine 80.2 40 14506273 (6), 16729965 (4), 18670092 (2), 17142562 (2) (see all 18)
    cirazoline 66.1 2 15028572 (1), 11414662 (1)
    quinidine 58.3 6 19528813 (4)
    tetraethylammonium 57.3 9 15459889 (2), 15795384 (2), 10825452 (1)
    moxonidine 56.7 2 15028572 (1), 11414662 (1)
    desipramine 43.5 2 15028572 (1), 11414662 (1)
    verapamil 38.8 2 15028572 (1), 11414662 (1)
    putrescine 31.7 1 15028572 (1)

    1 PharmGKB related drug/compound annotation for SLC22A4 gene    About this table
    Drug/compound PharmGKB Annotation
    imatinibCA  



    Find genes that share compounds with SLC22A4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC22A4 gene: 
    NM_003059.2  

    Unigene Cluster for SLC22A4:

    Solute carrier family 22 (organic cation/ergothioneine transporter), member 4
    Hs.310591  [show with all ESTs]
    Unigene Representative Sequence: NM_003059
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000200652(uc003kwq.3) ENST00000491257(uc010jdq.1) ENST00000425923

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC22A4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC22A4
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC22A4
    Predesigned siRNA for gene silencing in human, mouse, rat SLC22A4
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC22A4 (see all 7)
    OriGene ORF clones in mouse, rat for SLC22A4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC22A4 (NM_003059)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC22A4
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC22A4
      QuantiTect SYBR Green Assays in human, mouse, rat SLC22A4
      QuantiFast Probe-based Assays in human, mouse, rat SLC22A4

    Additional mRNA sequence: 

    AB007448.1 AK309243.1 AK310818.1 BC028313.1 Y09881.1 

    2 DOTS entries:

    DT.412871  DT.120834236 

    17 AceView cDNA sequences:

    BX492102 AA424257 AW027260 BG748566 BM045364 BX538252 BX091654 AA910874 
    BG831622 BG012623 AV724303 AW139326 BG681821 AL699579 BG201058 AA228830 
    BG436520 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC22A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGTCAAGG
    SLC22A4 Expression
    About this image


    SLC22A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Eye (Sensory Organs)
             Retina
    SLC22A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.310591

    UniProtKB/Swiss-Prot: S22A4_HUMAN, Q9H015
    Tissue specificity: Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver.
    Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal
    cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed
    in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral
    blood mononuclear cells

        Custom PCR Arrays for SLC22A4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC22A4
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC22A4
    QuantiTect SYBR Green Assays in human, mouse, rat SLC22A4
    QuantiFast Probe-based Assays in human, mouse, rat SLC22A4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a41 , 5 solute carrier family 22 (organic cation transporter), member 4 less1, 5 86.93(n)1
    85.12(a)1
      11 (32.07 cM)5
    308051  NM_019687.31  NP_062661.11 
     539831235 
    chicken
    (Gallus gallus)
    Aves SLC22A41 solute carrier family 22 (organic cation transporter), member 4 less 78.02(n)
    77.23(a)
      416327  NM_001146131.1  NP_001139603.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC22A46
    solute carrier family 22 (organic cation/zwitterio...
    75(a)
    1 ↔ 1
    2(127902870-127973293)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000006851 solute carrier family 22 member 4-like 56.78(n)
    48.88(a)
      100000685  XM_005170337.1  XP_005170394.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Orct3 carnitine transporter 36(a)
    (best of 18)
      95F8   --


    ENSEMBL Gene Tree for SLC22A4 (if available)
    TreeFam Gene Tree for SLC22A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC22A4 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A22  SLC22A102  SLC22A132  
    SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A32  SLC22A252  
    13 SIMAP similar genes for SLC22A4 using alignment to 2 protein entries:     S22A4_HUMAN (see all proteins):
    SLC22A5    SLC22A15    SLC22A1    SLC22A16    SLC22A2    SLC22A13
    SLC22A3    SLC22A7    SLC22A8    SLC22A6    SLC22A12    SLC22A11
    SLC22A20

    Find genes that share paralogs with SLC22A4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC22A4 (see all 1066)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10501521,2,,4
    C,F,Hnon-pathogenic1131952171(+) GAATCC/TTCACC 2 L F mis1 ese327Minor allele frequency- T:0.27NA NS EA EU 8877
    rs1922533971,2
    --126834371(+) ATATAA/TATATA 1 -- int10--------
    rs3691671961,2
    C--131633712(+) TTGAA-/CCCTTG 1 -- int10--------
    rs1474448431,2
    C--131635088(+) TTTCG-/TTTTA 
            
    TTTTA
    1 -- int10--------
    rs4047711,2
    C,A--131635092(+) GTTTTT/ATTTTA 1 -- int15Minor allele frequency- A:0.00NA WA CSA 8
    rs678068761,2
    C--131635113(+) TTTTATTTTA/
            
    TTTTA
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs1116752891,2
    C--131635292(+) AGTTTTTTG/-  
            
    TTTGT
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs578122591,2
    C--131635295(+) TGTTT-/GTTT  
            
    TTTGT
    1 -- int11Minor allele frequency- GTTT:0.50NA 2
    rs2012823711,2
    C--131637519(+) TTTCT-/TTC   
      T
    /TTTC
    ATCAG
    1 -- int10--------
    rs578670251,2
    C--131638989(+) ACACA-/AC/CA 
            
    TTTAG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC22A4 (131630136 - 131679899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SLC22A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882898CNV Loss21882294
    nsv882890CNV Loss21882294
    nsv882903CNV Loss21882294
    dgv6331n71CNV Loss21882294
    dgv6330n71CNV Loss21882294
    dgv6328n71CNV Loss21882294
    nsv882902CNV Loss21882294
    nsv882904CNV Loss21882294
    dgv6329n71CNV Loss21882294
    dgv6327n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLC22A4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604190   
    OMIM disorders: 180300  
    UniProtKB/Swiss-Prot: S22A4_HUMAN, Q9H015
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex
    genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial
    membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal
    tissues, and by atrophy and rarefaction of bony structures. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 1 disease for SLC22A4:    
    About MalaCards
    rheumatoid arthritis

    3 diseases from the University of Copenhagen DISEASES database for SLC22A4:
    Crohn's disease     Ulcerative colitis     Rheumatoid arthritis

    Find genes that share disorders with SLC22A4           About GenesLikeMe

    6 Novoseek inferred disease relationships for SLC22A4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory bowel diseases 59.3 2 16519742 (1)
    rheumatoid arthritis 40.3 14 17142562 (2), 17086603 (1), 16796743 (1), 18328148 (1) (see all 9)
    genetic susceptibility 32.8 1 16333318 (1)
    necrosis 0 1 17142562 (1)
    tumors 0 1 17142562 (1)
    cancer 0 1 12021398 (1)

    Genetic Association Database (GAD): SLC22A4
    Human Genome Epidemiology (HuGE) Navigator: SLC22A4 (70 documents)

    Export disorders for SLC22A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC22A4 gene, integrated from 10 sources (see all 157):
    (articles sorted by number of sources associating them with SLC22A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of the ergothioneine transporter. (PubMed id 15795384)1, 2, 3, 9 Gruendemann D.... Schoemig E. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. (PubMed id 9426230)1, 2, 3, 9 Tamai I.... Tsuji A. (FEBS Lett. 1997)
    3. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. (PubMed id 19536068)1, 4, 7, 9 Tzvetkov M.V....BrockmAPller J. (Clin. Pharmacol. Ther. 2009)
    4. Functional variants of OCTN cation transporter genes are associated with Crohn disease. (PubMed id 15107849)1, 2, 4 Peltekova V.D.... Siminovitch K.A. (Nat. Genet. 2004)
    5. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. (PubMed id 14608356)1, 2, 4 Tokuhiro S.... Yamamoto K. (Nat. Genet. 2003)
    6. Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. (PubMed id 10215651)1, 2, 7 Yabuuchi H.... Tsuji A. (J. Pharmacol. Exp. Ther. 1999)
    7. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. (PubMed id 17609685)1, 4, 9 Urban T.J....Giacomini K.M. (Clin. Pharmacol. Ther. 2008)
    8. Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population. (PubMed id 15459889)1, 2, 9 Kawasaki Y.... Tsuji A. (J. Pharm. Sci. 2004)
    9. Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5). (PubMed id 19141711)1, 4, 9 Tahara H....Giacomini K.M. (J. Pharmacol. Exp. Ther. 2009)
    10. Genetic variations of the SLC22A4 gene in Chinese and Indian populations of Singapore. (PubMed id 19881261)1, 4, 9 Toh D.S....Lee E.J. (Drug Metab. Pharmacokinet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6583 HGNC: 10968 AceView: SLC22A4.1 Ensembl:ENSG00000197208 euGenes: HUgn6583
    ECgene: SLC22A4 H-InvDB: SLC22A4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC22A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC22A4 gene:
    Search GeneIP for patents involving SLC22A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for SLC22A4 (OCTN1/SLC22A4)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC22A4  
     OriGene qPCR primer pairs and template standards for SLC22A4   OriGene Protein Over-expression Lysate for SLC22A4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC22A4  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC22A4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC22A4   OriGene Custom Protein Services for SLC22A4  

     
     
     Block miRNA regulation of human, mouse, rat SLC22A4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC22A4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A4 Predesigned siRNA for gene silencing in human, mouse, rat SLC22A4
     QuantiFast Probe-based Assays in human, mouse, rat SLC22A4 QuantiTect SYBR Green Assays in human, mouse, rat SLC22A4
     Custom PCR Arrays for SLC22A4 Search Chromatin IP Primers for SLC22A4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC22A4  GeneGlobe Interaction Network for SLC22A4
     Regulatory tfbs in SLC22A4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC22A4 GenScript cDNA clones with any tag delivered in your preferred vector for SLC22A4
     GenScript Custom Assay Services for SLC22A4 GenScript Custom overexpressing Cell Line Services for SLC22A4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC22A4 (S22A4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC22A4 antibodies
     SLC22A4 proteins
     SLC22A4 lysates
     Antibodies for SLC22A4
     See all of Abcam's Antibodies, Kits and Proteins for SLC22A4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC22A4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A4
     SwitchGear 3'UTR luciferase reporter plasmids for SLC22A4
     SwitchGear Promoter luciferase reporter plasmids for SLC22A4
     ThermoFisher Antibodies for SLC22A4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC22A4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC22A4
     LSBio Antibodies in human, mouse, rat for SLC22A4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC22A4
      Search eBioscience for proteins for SLC22A4
      Search eBioscience for elisas for SLC22A4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC22A4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4