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SLC22A31 Gene

protein-coding   GIFtS: 28
GCID: GC16M089263

Solute Carrier Family 22, Member 31

  Search for SLC22A31
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22, Member 311 2
Putative Solute Carrier Family 22 Member 312
Putative Solute Carrier Family 22 Member ENSG000001821572

External Ids:    HGNC: 270911   Entrez Gene: 1464292   Ensembl: ENSG000002598037   UniProtKB: A6NKX43   

Export aliases for SLC22A31 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC22A31 Gene:
SLC22A31 (solute carrier family 22, member 31) is a protein-coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A23.

UniProtKB/Swiss-Prot: S22AV_HUMAN, A6NKX4
Function: Organic anion transporter that mediates the uptake of ions (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC22A31
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

SLC22A31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A31 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M089263:  view genomic region     (about GC identifiers)

Start:
89,262,169 bp from pter      End:
89,268,072 bp from pter
Size:
5,904 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: S22AV_HUMAN, A6NKX4 (See protein sequence)
Recommended Name: Putative solute carrier family 22 member 31  
Size: 558 amino acids; 58987 Da

Explore the universe of human proteins at neXtProt for SLC22A31: NX_A6NKX4

REFSEQ proteins: NP_001229686.1  
ENSEMBL proteins: 
 ENSP00000474621  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

3 InterPro protein domains:
 IPR005828 Sub_transporter
 IPR020846 MFS_dom
 IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry A6NKX4

ProtoNet protein and cluster: A6NKX4

UniProtKB/Swiss-Prot: S22AV_HUMAN, A6NKX4
Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
family


SLC22A31 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: S22AV_HUMAN, A6NKX4
Function: Organic anion transporter that mediates the uptake of ions (Potential)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0022857transmembrane transporter activity IEA--
     
SLC22A31 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S22AV_HUMAN, A6NKX4: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

SLC22A31 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A31
Interactions:

    Search GeneGlobe Interaction Network for SLC22A31

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006811ion transport IEA--
GO:0055085transmembrane transport ----

SLC22A31 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for SLC22A31 (S22AV)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SLC22A31 gene: 
NM_001242757.1  

Unigene Cluster for SLC22A31:

Solute carrier family 22, member 31
Hs.447544  [show with all ESTs]
Unigene Representative Sequence: NM_001242757
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000562855(uc021tmr.1) ENST00000563595 ENST00000562916 ENST00000568161
ENST00000603735
miRNA
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4 DOTS entries:

DT.40214388  DT.75145325  DT.92031041  DT.102821140 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC22A31 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTGAGTACC
SLC22A31 Expression
About this image

SLC22A31 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.447544
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SLC22A31 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia SLC22A311 solute carrier family 22, member 31 81.78(n)
76.09(a)
  608796  XM_005620560.1  XP_005620617.1 
chicken
(Gallus gallus)
Aves SLC22A311 solute carrier family 22, member 31 65.45(n)
54.88(a)
  100857161  XM_003643532.2  XP_003643580.2 
lizard
(Anolis carolinensis)
Reptilia SLC22A316
solute carrier family 22, member 31
51(a)
1 ↔ 1
GL343487.1(243167-254378)
zebrafish
(Danio rerio)
Actinopterygii SLC22A316
solute carrier family 22, member 31
35(a)
1 ↔ 1
7(57690264-57732027) ENSDARG00000078882


ENSEMBL Gene Tree for SLC22A31 (if available)
TreeFam Gene Tree for SLC22A31 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC22A31 gene
SLC22A232  SLC22A172  
4 SIMAP similar genes for SLC22A31 using alignment to 2 protein entries:     S22AV_HUMAN (see all proteins):
SLC22A17    DKFZp434F011    SLC22A23    SLC22A7

SLC22A31 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC22A31 (see all 111)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs351469331,2
--89262419(+) TGCTCA/GGGGGT 2 P syn10--------
rs22873531,2
C,F--89262431(-) TGGGCC/TGGCCA 2 A syn14Minor allele frequency- T:0.18EA NS NA 1780
rs1871687621,2
C--89262438(+) CCCAGC/TAGGAG 2 Y C mis10--------
rs1511275611,2
--89262453(+) AGGGCA/GGCAGC 2 P L mis10--------
rs1920412291,2
--89262610(+) GAAGAC/TGACTT 2 I V mis10--------
rs1172344711,2
C,F--89262646(+) GTGCAG/AGGTGT 2 /L syn11Minor allele frequency- A:0.03EA 120
rs1171696281,2
C,F--89262657(+) CCAGGG/AGGCCG 2 /P /L mis11Minor allele frequency- A:0.15NA 120
rs1414220891,2
C--89262866(+) CCAGG-/AACCCGGC 1 -- cds10--------
rs732640061,2
C,F--89262964(+) GGCCCG/AGCCTC 1 -- int12Minor allele frequency- A:0.06WA 120
rs1834469121,2
--89263103(+) GTAATC/TCCAGC 1 -- int10--------

HapMap Linkage Disequilibrium report for SLC22A31 (89262169 - 89268072 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SLC22A31 (see all 19):    About this table    
Variant IDTypeSubtypePubMed ID
esv2715127CNV Deletion23290073
esv2715130CNV Deletion23290073
esv1002217CNV Deletion20482838
esv2715128CNV Deletion23290073
esv1613886CNV Deletion17803354
nsv509638CNV Insertion20534489
nsv907394CNV Loss21882294
nsv907360CNV Loss21882294
nsv907357CNV Loss21882294
nsv907268CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for SLC22A31 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SLC22A31)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 146429 HGNC: 27091 Ensembl:ENSG00000259803 euGenes: HUgn146429 ECgene: SLC22A31
H-InvDB: SLC22A31

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC22A31 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC22A31 gene:
Search GeneIP for patents involving SLC22A31

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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