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Aliases for SLC22A31 Gene

Aliases for SLC22A31 Gene

  • Solute Carrier Family 22 Member 31 2 3 5
  • Solute Carrier Family 22, Member 31 2

External Ids for SLC22A31 Gene

Previous GeneCards Identifiers for SLC22A31 Gene

  • GC16M089263

Summaries for SLC22A31 Gene

GeneCards Summary for SLC22A31 Gene

SLC22A31 (Solute Carrier Family 22 Member 31) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A17.

UniProtKB/Swiss-Prot for SLC22A31 Gene

  • Organic anion transporter that mediates the uptake of ions.

Additional gene information for SLC22A31 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A31 Gene

Genomics for SLC22A31 Gene

GeneHancer (GH) Regulatory Elements for SLC22A31 Gene

Promoters and enhancers for SLC22A31 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I089201 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 574.9 -0.2 -230 0.6 MXI1 USF1 RB1 SAP130 ARID4B SIN3A ZIC2 POLR2A VEZF1 ZSCAN29 SLC22A31 ZNF778 CDH15 LINC02138 CBFA2T3 ENSG00000259877
GH16I089200 Enhancer 1 ENCODE dbSUPER 550.8 +1.3 1253 0.2 ELF3 ARID4B DMAP1 THRB RARA CREM THAP11 KLF11 SP5 ZHX2 ZNF778 SLC22A31 CDH15 LINC02138 CBFA2T3
GH16I089199 Promoter/Enhancer 1 EPDnew dbSUPER 550.8 +1.7 1728 0.1 POLR2A MXD3 MXD4 NR2C2 SLC22A31 CDH15
GH16I089191 Enhancer 1.4 Ensembl ENCODE dbSUPER 27.7 +8.8 8786 3.3 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 GLIS2 SLC22A31 ENSG00000259877 ACSF3 ENSG00000260279 CDH15
GH16I089216 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.6 -15.6 -15644 2.6 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 ENSG00000259877 PIR52460 ZNF778 AFG3L1P TCF25 CDK10 TRAPPC2L PIEZO1 CTU2 ZNF276
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC22A31 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC22A31 Gene

Genomic Locations for SLC22A31 Gene
5,916 bases
Minus strand

Genomic View for SLC22A31 Gene

Genes around SLC22A31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A31 Gene

Proteins for SLC22A31 Gene

  • Protein details for SLC22A31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative solute carrier family 22 member 31
    Protein Accession:

    Protein attributes for SLC22A31 Gene

    558 amino acids
    Molecular mass:
    58987 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A31 Gene

Post-translational modifications for SLC22A31 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC22A31 Gene

Domains & Families for SLC22A31 Gene

Gene Families for SLC22A31 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SLC22A31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A31: view

No data available for Suggested Antigen Peptide Sequences for SLC22A31 Gene

Function for SLC22A31 Gene

Molecular function for SLC22A31 Gene

UniProtKB/Swiss-Prot Function:
Organic anion transporter that mediates the uptake of ions.

Gene Ontology (GO) - Molecular Function for SLC22A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008514 organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A31: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A31 Gene

Localization for SLC22A31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A31 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC22A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC22A31: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SLC22A31 Gene

Pathways & Interactions for SLC22A31 Gene

SuperPathways for SLC22A31 Gene

No Data Available

Interacting Proteins for SLC22A31 Gene

Gene Ontology (GO) - Biological Process for SLC22A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015711 organic anion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A31: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A31 Gene

Drugs & Compounds for SLC22A31 Gene

No Compound Related Data Available

Transcripts for SLC22A31 Gene

mRNA/cDNA for SLC22A31 Gene

(8) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A31 Gene

Solute carrier family 22, member 31:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A31 Gene

No ASD Table

Relevant External Links for SLC22A31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC22A31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A31 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A31 Gene

This gene is overexpressed in Brain - Cerebellum (x19.2), Brain - Cerebellar Hemisphere (x15.5), Lung (x7.8), and Pancreas (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of SLC22A31 Gene:


SOURCE GeneReport for Unigene cluster for SLC22A31 Gene:

genes like me logo Genes that share expression patterns with SLC22A31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A31 Gene

Orthologs for SLC22A31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC22A31 33
  • 97.93 (n)
(Canis familiaris)
Mammalia SLC22A31 33 34
  • 81.78 (n)
(Monodelphis domestica)
Mammalia SLC22A31 34
  • 59 (a)
(Bos Taurus)
Mammalia MGC157263 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia SLC22A31 34
  • 55 (a)
(Gallus gallus)
Aves SLC22A31 33
  • 65.45 (n)
(Anolis carolinensis)
Reptilia SLC22A31 34
  • 51 (a)
(Danio rerio)
Actinopterygii SLC22A31 34
  • 35 (a)
Species where no ortholog for SLC22A31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A31 Gene

Gene Tree for SLC22A31 (if available)
Gene Tree for SLC22A31 (if available)

Paralogs for SLC22A31 Gene

Paralogs for SLC22A31 Gene

(4) SIMAP similar genes for SLC22A31 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC22A31: view

Variants for SLC22A31 Gene

Sequence variations from dbSNP and Humsavar for SLC22A31 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000041781 -- 89,201,760(-) G/C upstream_transcript_variant
rs1000523714 -- 89,196,137(-) C/T coding_sequence_variant, synonymous_variant
rs1000653062 -- 89,198,953(-) C/T 5_prime_UTR_variant, intron_variant
rs1000749275 -- 89,200,455(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000800276 -- 89,200,275(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A31 Gene

Variant ID Type Subtype PubMed ID
dgv3066n100 CNV gain 25217958
dgv5320n54 CNV loss 21841781
esv1002217 CNV deletion 20482838
esv1613886 CNV deletion 17803354
esv2715127 CNV deletion 23290073
esv2715128 CNV deletion 23290073
esv2715130 CNV deletion 23290073
esv2763149 CNV gain 21179565
nsv1063024 CNV gain 25217958
nsv457621 CNV loss 19166990
nsv471115 CNV loss 18288195
nsv482951 CNV loss 15286789
nsv509638 CNV insertion 20534489
nsv519104 CNV loss 19592680
nsv573674 CNV gain 21841781
nsv573724 CNV loss 21841781
nsv952072 CNV deletion 24416366

Variation tolerance for SLC22A31 Gene

Gene Damage Index Score: 13.04; 95.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A31 Gene

Disorders for SLC22A31 Gene

Additional Disease Information for SLC22A31

No disorders were found for SLC22A31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A31 Gene

Publications for SLC22A31 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58

Products for SLC22A31 Gene

Sources for SLC22A31 Gene

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