Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC22A31 Gene

Aliases for SLC22A31 Gene

  • Solute Carrier Family 22 Member 31 2 3 5
  • Solute Carrier Family 22, Member 31 2

External Ids for SLC22A31 Gene

Previous GeneCards Identifiers for SLC22A31 Gene

  • GC16M089263

Summaries for SLC22A31 Gene

GeneCards Summary for SLC22A31 Gene

SLC22A31 (Solute Carrier Family 22 Member 31) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A17.

UniProtKB/Swiss-Prot for SLC22A31 Gene

  • Organic anion transporter that mediates the uptake of ions.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A31 Gene

Genomics for SLC22A31 Gene

Regulatory Elements for SLC22A31 Gene

Enhancers for SLC22A31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F089190 1.3 Ensembl ENCODE 27.7 +8.3 8336 6.0 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 SLC22A31 ACSF3 CDH15 ENSG00000260279
GH16F089216 1.1 ENCODE 9.6 -15.6 -15643 2.6 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000259877 CDK10 TRAPPC2L MIR4722 PIEZO1 CTU2 AFG3L1P SNORD68 MC1R SLC22A31
GH16F089355 1.7 FANTOM5 Ensembl ENCODE 5.7 -161.6 -161586 14.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 YY1 SLC30A9 ZNF143 FOS ENSG00000259877 CTU2 RNU6-430P ZNF778 ANKRD11 DBNDD1 SPG7 LINC00304 SLC22A31 ZNF276
GH16F089093 1.1 ENCODE 8.5 +107.4 107436 1.9 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ELK1 ZNF207 ZNF143 MXD4 ZNF778 ACSF3 SLC22A31 CDK10 LINC00304 PIR52081 ENSG00000261546
GH16F089313 2 VISTA FANTOM5 Ensembl ENCODE 4.6 -119.3 -119339 15.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 YY1 FOS ZNF263 SP5 LOC100289580 ENSG00000259877 TRAPPC2L CTU2 FAM157C ENSG00000261172 AFG3L1P CDK10 DBNDD1 ZNF276
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC22A31 on UCSC Golden Path with GeneCards custom track

Promoters for SLC22A31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000512241 -29 1401 TBP MXI1 SUZ12 SAP130 ARID4B SIN3A ZIC2 POLR2A ZSCAN29 EZH2

Genomic Location for SLC22A31 Gene

Chromosome:
16
Start:
89,195,756 bp from pter
End:
89,201,671 bp from pter
Size:
5,916 bases
Orientation:
Minus strand

Genomic View for SLC22A31 Gene

Genes around SLC22A31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A31 Gene

Proteins for SLC22A31 Gene

  • Protein details for SLC22A31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKX4-S22AV_HUMAN
    Recommended name:
    Putative solute carrier family 22 member 31
    Protein Accession:
    A6NKX4

    Protein attributes for SLC22A31 Gene

    Size:
    558 amino acids
    Molecular mass:
    58987 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A31 Gene

Post-translational modifications for SLC22A31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC22A31 Gene

Domains & Families for SLC22A31 Gene

Gene Families for SLC22A31 Gene

Protein Domains for SLC22A31 Gene

Graphical View of Domain Structure for InterPro Entry

A6NKX4

UniProtKB/Swiss-Prot:

S22AV_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A31: view

No data available for Suggested Antigen Peptide Sequences for SLC22A31 Gene

Function for SLC22A31 Gene

Molecular function for SLC22A31 Gene

UniProtKB/Swiss-Prot Function:
Organic anion transporter that mediates the uptake of ions.

Gene Ontology (GO) - Molecular Function for SLC22A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008514 organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A31: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A31 Gene

Localization for SLC22A31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A31 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC22A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A31: view

No data available for Subcellular locations from COMPARTMENTS for SLC22A31 Gene

Pathways & Interactions for SLC22A31 Gene

SuperPathways for SLC22A31 Gene

No Data Available

Interacting Proteins for SLC22A31 Gene

Gene Ontology (GO) - Biological Process for SLC22A31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015711 organic anion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A31: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A31 Gene

Transcripts for SLC22A31 Gene

mRNA/cDNA for SLC22A31 Gene

(8) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A31 Gene

Solute carrier family 22, member 31:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A31 Gene

No ASD Table

Relevant External Links for SLC22A31 Gene

GeneLoc Exon Structure for
SLC22A31
ECgene alternative splicing isoforms for
SLC22A31

Expression for SLC22A31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A31 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A31 Gene

This gene is overexpressed in Brain - Cerebellum (x19.2), Brain - Cerebellar Hemisphere (x15.5), Lung (x7.8), and Pancreas (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of SLC22A31 Gene:

SLC22A31

SOURCE GeneReport for Unigene cluster for SLC22A31 Gene:

Hs.447544
genes like me logo Genes that share expression patterns with SLC22A31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC22A31 Gene

Orthologs for SLC22A31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A31 34
  • 97.93 (n)
dog
(Canis familiaris)
Mammalia SLC22A31 34 35
  • 81.78 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC22A31 35
  • 59 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC157263 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A31 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A31 34
  • 65.45 (n)
lizard
(Anolis carolinensis)
Reptilia SLC22A31 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SLC22A31 35
  • 35 (a)
OneToOne
Species where no ortholog for SLC22A31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A31 Gene

ENSEMBL:
Gene Tree for SLC22A31 (if available)
TreeFam:
Gene Tree for SLC22A31 (if available)

Paralogs for SLC22A31 Gene

Paralogs for SLC22A31 Gene

(4) SIMAP similar genes for SLC22A31 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC22A31: view

Variants for SLC22A31 Gene

Sequence variations from dbSNP and Humsavar for SLC22A31 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111849627 -- 89,202,545(+) TGTTG(C/G)GGGAC intron-variant, upstream-variant-2KB
rs112083449 -- 89,201,529(+) CGCGG(A/G)CTGCG upstream-variant-2KB, utr-variant-5-prime
rs112092714 -- 89,196,895(+) GAGCT(C/G)AGATC intron-variant
rs112450324 -- 89,201,141(+) AGGAA(A/G)CCCAG intron-variant, upstream-variant-2KB
rs113158416 -- 89,201,469(+) GGGTC(C/T)GCGCA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC22A31 Gene

Variant ID Type Subtype PubMed ID
dgv3066n100 CNV gain 25217958
dgv5320n54 CNV loss 21841781
esv1002217 CNV deletion 20482838
esv1613886 CNV deletion 17803354
esv2715127 CNV deletion 23290073
esv2715128 CNV deletion 23290073
esv2715130 CNV deletion 23290073
esv2763149 CNV gain 21179565
nsv1063024 CNV gain 25217958
nsv457621 CNV loss 19166990
nsv471115 CNV loss 18288195
nsv482951 CNV loss 15286789
nsv509638 CNV insertion 20534489
nsv519104 CNV loss 19592680
nsv952072 CNV deletion 24416366
nsv573724 CNV loss 21841781
nsv573674 CNV gain 21841781

Variation tolerance for SLC22A31 Gene

Gene Damage Index Score: 13.04; 95.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A31 Gene

Disorders for SLC22A31 Gene

Relevant External Links for SLC22A31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A31

No disorders were found for SLC22A31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A31 Gene

Publications for SLC22A31 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64

Products for SLC22A31 Gene

Sources for SLC22A31 Gene

Content
Loading form....