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Aliases for SLC22A3 Gene

Aliases for SLC22A3 Gene

  • Solute Carrier Family 22 Member 3 2 3
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 3 2 3 5
  • Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 3 2 3
  • Extraneuronal Monoamine Transporter 3 4
  • Organic Cation Transporter 3 3 4
  • OCT3 3 4
  • EMTH 3 4
  • EMT 3 4
  • EMT Organic Cation Transporter 3 3

External Ids for SLC22A3 Gene

Previous GeneCards Identifiers for SLC22A3 Gene

  • GC06P160208
  • GC06P160642
  • GC06P160678
  • GC06P160739
  • GC06P158244

Summaries for SLC22A3 Gene

Entrez Gene Summary for SLC22A3 Gene

  • Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A3 Gene

SLC22A3 (Solute Carrier Family 22 Member 3) is a Protein Coding gene. Diseases associated with SLC22A3 include Solar Retinopathy and Spermatocytoma. Among its related pathways are Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transmembrane transporter activity and organic cation transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A3 Gene

  • Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Gene Wiki entry for SLC22A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A3 Gene

Genomics for SLC22A3 Gene

Regulatory Elements for SLC22A3 Gene

Enhancers for SLC22A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC22A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC22A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC22A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A3 Gene

Chromosome:
6
Start:
160,348,268 bp from pter
End:
160,452,581 bp from pter
Size:
104,314 bases
Orientation:
Plus strand

Genomic View for SLC22A3 Gene

Genes around SLC22A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A3 Gene

Proteins for SLC22A3 Gene

  • Protein details for SLC22A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75751-S22A3_HUMAN
    Recommended name:
    Solute carrier family 22 member 3
    Protein Accession:
    O75751
    Secondary Accessions:
    • Q5SYN6
    • Q9UP02

    Protein attributes for SLC22A3 Gene

    Size:
    556 amino acids
    Molecular mass:
    61280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A3 Gene

Proteomics data for SLC22A3 Gene at MOPED

Post-translational modifications for SLC22A3 Gene

  • Glycosylation at Asn 72, Asn 99, Asn 119, and Asn 322
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC22A3 Gene

Domains & Families for SLC22A3 Gene

Gene Families for SLC22A3 Gene

Protein Domains for SLC22A3 Gene

Graphical View of Domain Structure for InterPro Entry

O75751

UniProtKB/Swiss-Prot:

S22A3_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A3: view

Function for SLC22A3 Gene

Molecular function for SLC22A3 Gene

GENATLAS Biochemistry:
solute carrier family 22,member A3,polyspecific transporter of organic cations,most abundantly expressed in the placenta and moderatly in the intestine,heart and brain,clustered with SLC22A1 and SLC22A2
UniProtKB/Swiss-Prot Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
genes like me logo Genes that share phenotypes with SLC22A3: view

Animal Models for SLC22A3 Gene

MGI Knock Outs for SLC22A3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A3 Gene

Localization for SLC22A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A3 Gene COMPARTMENTS Subcellular localization image for SLC22A3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9933568
genes like me logo Genes that share ontologies with SLC22A3: view

Pathways & Interactions for SLC22A3 Gene

genes like me logo Genes that share pathways with SLC22A3: view

Gene Ontology (GO) - Biological Process for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015844 monoamine transport IEA --
GO:0015872 dopamine transport IEA,IBA --
GO:0044281 small molecule metabolic process TAS --
GO:0051608 histamine transport IEA --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with SLC22A3: view

No data available for SIGNOR curated interactions for SLC22A3 Gene

Drugs & Compounds for SLC22A3 Gene

(45) Drugs for SLC22A3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desipramine Approved Pharma Transporter, inhibitor 39
Dopamine Approved Pharma Full agonist, Agonist, Transporter, inhibitor 3636
Guanidine Approved Pharma Transporter, substrate, inhibitor 0
Norepinephrine Approved Pharma Transporter, substrate, inhibitor 654
Metformin Approved Pharma Transporter, substrate AMP-activated protein kinase (AMPK) activator 1668

(9) Additional Compounds for SLC22A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC22A3: view

Transcripts for SLC22A3 Gene

Unigene Clusters for SLC22A3 Gene

Solute carrier family 22 (extraneuronal monoamine transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for SLC22A3 Gene

GeneLoc Exon Structure for
SLC22A3
ECgene alternative splicing isoforms for
SLC22A3

Expression for SLC22A3 Gene

mRNA expression in normal human tissues for SLC22A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A3 Gene

This gene is overexpressed in Artery - Aorta (x6.5), Muscle - Skeletal (x6.0), Nerve - Tibial (x4.9), and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for SLC22A3 Gene

This gene is overexpressed in Seminal vesicle (19.6), Prostate (16.8), Liver (11.5), and Ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC22A3 Gene



SOURCE GeneReport for Unigene cluster for SLC22A3 Gene Hs.567337

mRNA Expression by UniProt/SwissProt for SLC22A3 Gene

O75751-S22A3_HUMAN
Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.
genes like me logo Genes that share expression patterns with SLC22A3: view

Primer Products

No data available for Protein tissue co-expression partners for SLC22A3 Gene

Orthologs for SLC22A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC22A3 35
  • 89.49 (n)
  • 93.87 (a)
SLC22A3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A3 35
  • 89.27 (n)
  • 92.36 (a)
SLC22A3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a3 35
  • 85 (n)
  • 87.3 (a)
Slc22a3 16
Slc22a3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC22A3 35
  • 99.52 (n)
  • 99.64 (a)
SLC22A3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a3 35
  • 85.48 (n)
  • 87.11 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC22A3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A3 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A3 35
  • 72.47 (n)
  • 75 (a)
SLC22A3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A3 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:175176 35
  • 54.41 (n)
  • 47.84 (a)
SLC22A3 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13610 37
  • 30 (a)
CG14857 37
  • 25 (a)
CG16727 37
  • 24 (a)
CG17751 37
  • 27 (a)
CG17752 37
  • 26 (a)
CG3790 37
  • 29 (a)
CG5592 37
  • 27 (a)
CG6126 37
  • 29 (a)
CG6231 37
  • 26 (a)
CG6600 37
  • 33 (a)
CG7084 37
  • 24 (a)
CG7442 37
  • 28 (a)
CG7458 37
  • 28 (a)
CG8654 37
  • 38 (a)
CG9317 37
  • 30 (a)
Orct 37
  • 31 (a)
CG4630 36
  • 29 (a)
ManyToMany
CG7442 36
  • 27 (a)
ManyToMany
CG7458 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea B0252.3 37
  • 27 (a)
F52F12.1a 37
  • 29 (a)
K05F1.6 37
  • 27 (a)
oct-1 37
  • 29 (a)
Y82E9BR.16 37
  • 26 (a)
ZK455.8a 37
  • 26 (a)
ZK455.8b 37
  • 26 (a)
Species with no ortholog for SLC22A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A3 Gene

ENSEMBL:
Gene Tree for SLC22A3 (if available)
TreeFam:
Gene Tree for SLC22A3 (if available)

Paralogs for SLC22A3 Gene

Pseudogenes.org Pseudogenes for SLC22A3 Gene

genes like me logo Genes that share paralogs with SLC22A3: view

Variants for SLC22A3 Gene

Sequence variations from dbSNP and Humsavar for SLC22A3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs8187715 - 160,348,550(+) GGGCA(C/G/T)GCAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs8187717 - 160,348,765(+) TCGCC(G/T)CCTTC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1050898 -- 160,451,705(+) AGGCC(C/T)TGTTC utr-variant-3-prime
rs1050908 -- 160,452,332(+) ATGTG(C/T)GCTAA utr-variant-3-prime
rs1112444 -- 160,414,160(+) cattt(A/C)cattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A3 Gene

Variant ID Type Subtype PubMed ID
dgv2024e1 CNV Complex 17122850
esv35098 CNV Gain 17911159
nsv818463 CNV Gain 17921354
dgv7013n71 CNV Gain 21882294
nsv886810 CNV Gain 21882294
essv6642 CNV CNV 17122850
essv24539 CNV CNV 17122850

Variation tolerance for SLC22A3 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A3 Gene

Human Gene Mutation Database (HGMD)
SLC22A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A3 Gene

Disorders for SLC22A3 Gene

MalaCards: The human disease database

(18) MalaCards diseases for SLC22A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
solar retinopathy
  • solar retinitis
spermatocytoma
  • spermatocytic seminoma
chorioretinal scar
vitreous detachment
combined thymoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC22A3

Genetic Association Database (GAD)
SLC22A3
Human Genome Epidemiology (HuGE) Navigator
SLC22A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A3
genes like me logo Genes that share disorders with SLC22A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A3 Gene

Publications for SLC22A3 Gene

  1. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (PMID: 10966924) Wu X. … Ganapathy V. (Am. J. Physiol. 2000) 3 23 25 26
  2. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. (PMID: 9933568) Verhaagh S. … Zwart R. (Genomics 1999) 2 3 4 67
  3. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. (PMID: 9632645) Kekuda R. … Ganapathy V. (J. Biol. Chem. 1998) 2 3 25 26
  4. Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine. (PMID: 19190342) Shnitsar V. … Hagos Y. (Cancer Res. 2009) 23 25 26
  5. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. (PMID: 19536068) Tzvetkov M.V. … BrockmAPller J. (Clin. Pharmacol. Ther. 2009) 23 25 26

Products for SLC22A3 Gene

Sources for SLC22A3 Gene

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