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Aliases for SLC22A3 Gene

Aliases for SLC22A3 Gene

  • Solute Carrier Family 22 Member 3 2 3 5
  • Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 3 2 3
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 3 2 3
  • Extraneuronal Monoamine Transporter 3 4
  • Organic Cation Transporter 3 3 4
  • OCT3 3 4
  • EMTH 3 4
  • EMT 3 4
  • EMT Organic Cation Transporter 3 3

External Ids for SLC22A3 Gene

Previous GeneCards Identifiers for SLC22A3 Gene

  • GC06P160208
  • GC06P160642
  • GC06P160678
  • GC06P160739
  • GC06P158244

Summaries for SLC22A3 Gene

Entrez Gene Summary for SLC22A3 Gene

  • Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A3 Gene

SLC22A3 (Solute Carrier Family 22 Member 3) is a Protein Coding gene. Diseases associated with SLC22A3 include Extragonadal Seminoma and Prostate Cancer Susceptibility. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Synaptic vesicle cycle. GO annotations related to this gene include transmembrane transporter activity and organic cation transmembrane transporter activity. An important paralog of this gene is SLC22A2.

UniProtKB/Swiss-Prot for SLC22A3 Gene

  • Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Gene Wiki entry for SLC22A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A3 Gene

Genomics for SLC22A3 Gene

Regulatory Elements for SLC22A3 Gene

Enhancers for SLC22A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC22A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC22A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC22A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A3 Gene

Chromosome:
6
Start:
160,348,268 bp from pter
End:
160,452,581 bp from pter
Size:
104,314 bases
Orientation:
Plus strand

Genomic View for SLC22A3 Gene

Genes around SLC22A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A3 Gene

Proteins for SLC22A3 Gene

  • Protein details for SLC22A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75751-S22A3_HUMAN
    Recommended name:
    Solute carrier family 22 member 3
    Protein Accession:
    O75751
    Secondary Accessions:
    • Q5SYN6
    • Q9UP02

    Protein attributes for SLC22A3 Gene

    Size:
    556 amino acids
    Molecular mass:
    61280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A3 Gene

Post-translational modifications for SLC22A3 Gene

  • Glycosylation at Asn 72, Asn 99, Asn 119, and Asn 322
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC22A3 Gene

Domains & Families for SLC22A3 Gene

Gene Families for SLC22A3 Gene

Protein Domains for SLC22A3 Gene

Graphical View of Domain Structure for InterPro Entry

O75751

UniProtKB/Swiss-Prot:

S22A3_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A3: view

Function for SLC22A3 Gene

Molecular function for SLC22A3 Gene

GENATLAS Biochemistry:
solute carrier family 22,member A3,polyspecific transporter of organic cations,most abundantly expressed in the placenta and moderatly in the intestine,heart and brain,clustered with SLC22A1 and SLC22A2
UniProtKB/Swiss-Prot Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

Gene Ontology (GO) - Molecular Function for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005329 dopamine transmembrane transporter activity IBA --
GO:0005515 protein binding IEA,IPI 17474147
GO:0015101 organic cation transmembrane transporter activity IEA,TAS --
GO:0015651 quaternary ammonium group transmembrane transporter activity IEA,IDA 10966924
GO:0019534 toxin transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A3: view
genes like me logo Genes that share phenotypes with SLC22A3: view

Animal Models for SLC22A3 Gene

MGI Knock Outs for SLC22A3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC22A3 Gene

Localization for SLC22A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A3 Gene COMPARTMENTS Subcellular localization image for SLC22A3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9933568
GO:0016020 membrane TAS 9933568
genes like me logo Genes that share ontologies with SLC22A3: view

Pathways & Interactions for SLC22A3 Gene

genes like me logo Genes that share pathways with SLC22A3: view

Gene Ontology (GO) - Biological Process for SLC22A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006855 drug transmembrane transport TAS --
GO:0015695 organic cation transport IEA,IDA 10966924
GO:0015697 quaternary ammonium group transport IEA,IDA 10966924
GO:0015844 monoamine transport IEA --
GO:0015872 dopamine transport IEA,IBA --
genes like me logo Genes that share ontologies with SLC22A3: view

No data available for SIGNOR curated interactions for SLC22A3 Gene

Drugs & Compounds for SLC22A3 Gene

(47) Drugs for SLC22A3 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desipramine Approved Pharma Transporter, inhibitor 39
Dopamine Approved Pharma Full agonist, Agonist, Transporter, inhibitor 3678
Guanidine Approved Pharma Transporter, substrate, inhibitor 0
Norepinephrine Approved Pharma Transporter, substrate, inhibitor 664
Metformin Approved Pharma Transporter, substrate AMP-activated protein kinase (AMPK) activator 1701

(8) Additional Compounds for SLC22A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC22A3: view

Transcripts for SLC22A3 Gene

Unigene Clusters for SLC22A3 Gene

Solute carrier family 22 (extraneuronal monoamine transporter), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for SLC22A3 Gene

GeneLoc Exon Structure for
SLC22A3
ECgene alternative splicing isoforms for
SLC22A3

Expression for SLC22A3 Gene

mRNA expression in normal human tissues for SLC22A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A3 Gene

This gene is overexpressed in Artery - Aorta (x6.5), Muscle - Skeletal (x6.0), Nerve - Tibial (x4.9), and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for SLC22A3 Gene

This gene is overexpressed in Seminal vesicle (19.6), Prostate (16.8), Liver (11.5), and Ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC22A3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC22A3 Gene:

SLC22A3

SOURCE GeneReport for Unigene cluster for SLC22A3 Gene:

Hs.567337

mRNA Expression by UniProt/SwissProt for SLC22A3 Gene:

O75751-S22A3_HUMAN
Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.
genes like me logo Genes that share expression patterns with SLC22A3: view

Primer Products

No data available for Protein tissue co-expression partners for SLC22A3 Gene

Orthologs for SLC22A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC22A3 34
  • 89.49 (n)
  • 93.87 (a)
SLC22A3 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A3 34
  • 89.27 (n)
  • 92.36 (a)
SLC22A3 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a3 34
  • 85 (n)
  • 87.3 (a)
Slc22a3 16
Slc22a3 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC22A3 34
  • 99.52 (n)
  • 99.64 (a)
SLC22A3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a3 34
  • 85.48 (n)
  • 87.11 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC22A3 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A3 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A3 34
  • 72.47 (n)
  • 75 (a)
SLC22A3 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A3 35
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:175176 34
  • 54.41 (n)
  • 47.84 (a)
SLC22A3 35
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13610 36
  • 30 (a)
CG14857 36
  • 25 (a)
CG16727 36
  • 24 (a)
CG17751 36
  • 27 (a)
CG17752 36
  • 26 (a)
CG3790 36
  • 29 (a)
CG5592 36
  • 27 (a)
CG6126 36
  • 29 (a)
CG6231 36
  • 26 (a)
CG6600 36
  • 33 (a)
CG7084 36
  • 24 (a)
CG7442 36
  • 28 (a)
CG7458 36
  • 28 (a)
CG8654 36
  • 38 (a)
CG9317 36
  • 30 (a)
Orct 36
  • 31 (a)
CG4630 35
  • 29 (a)
ManyToMany
CG7442 35
  • 27 (a)
ManyToMany
CG7458 35
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea B0252.3 36
  • 27 (a)
F52F12.1a 36
  • 29 (a)
K05F1.6 36
  • 27 (a)
oct-1 36
  • 29 (a)
Y82E9BR.16 36
  • 26 (a)
ZK455.8a 36
  • 26 (a)
ZK455.8b 36
  • 26 (a)
Species where no ortholog for SLC22A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC22A3 Gene

ENSEMBL:
Gene Tree for SLC22A3 (if available)
TreeFam:
Gene Tree for SLC22A3 (if available)

Paralogs for SLC22A3 Gene

Pseudogenes.org Pseudogenes for SLC22A3 Gene

genes like me logo Genes that share paralogs with SLC22A3: view

Variants for SLC22A3 Gene

Sequence variations from dbSNP and Humsavar for SLC22A3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs8187715 - 160,348,550(+) GGGCA(C/G/T)GCAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs8187717 - 160,348,765(+) TCGCC(G/T)CCTTC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs992942 -- 160,410,978(+) tgtat(A/G)tatat intron-variant
rs1050898 -- 160,451,705(+) AGGCC(C/T)TGTTC utr-variant-3-prime
rs1050908 -- 160,452,332(+) ATGTG(C/T)GCTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC22A3 Gene

Variant ID Type Subtype PubMed ID
esv2759484 CNV gain+loss 17122850
esv35098 CNV gain 17911159
esv3611428 CNV gain 21293372
nsv1020357 CNV loss 25217958
nsv1026543 CNV gain 25217958
nsv818463 CNV gain 17921354
nsv969462 CNV duplication 23825009

Variation tolerance for SLC22A3 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A3 Gene

Human Gene Mutation Database (HGMD)
SLC22A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A3 Gene

Disorders for SLC22A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC22A3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
extragonadal seminoma
  • primary extragonadal seminoma
prostate cancer susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC22A3

Genetic Association Database (GAD)
SLC22A3
Human Genome Epidemiology (HuGE) Navigator
SLC22A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A3
genes like me logo Genes that share disorders with SLC22A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A3 Gene

Publications for SLC22A3 Gene

  1. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (PMID: 10966924) Wu X. … Ganapathy V. (Am. J. Physiol. 2000) 3 4 22 25 65
  2. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. (PMID: 19591196) Nies A.T. … Schaeffeler E. (Hepatology 2009) 3 22 46 65
  3. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. (PMID: 17010131) Aoyama N. … Ozaki N. (Alcohol. Clin. Exp. Res. 2006) 3 22 46 65
  4. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. (PMID: 9933568) Verhaagh S. … Zwart R. (Genomics 1999) 2 3 4 65
  5. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. (PMID: 9632645) Kekuda R. … Ganapathy V. (J. Biol. Chem. 1998) 2 3 25 65

Products for SLC22A3 Gene

Sources for SLC22A3 Gene

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