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SLC22A3 Gene

protein-coding   GIFtS: 61
GCID: GC06P160739

Solute Carrier Family 22 (Organic Cation Transporter), Member...

(Previous names: solute carrier family 22 (extraneuronal monoamine transporter),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22 (Organic Cation Transporter), Member 31 2     EMTH2 3
EMT2 3 5     OCT32 3
Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 31 2     EMT Organic Cation Transporter 32
Extraneuronal Monoamine Transporter2 3     Solute Carrier Family 22 Member 32
Organic Cation Transporter 32 3     

External Ids:    HGNC: 109671   Entrez Gene: 65812   Ensembl: ENSG000001464777   OMIM: 6048425   UniProtKB: O757513   

Export aliases for SLC22A3 gene to outside databases

Previous GC identifers: GC06P160208 GC06P160642 GC06P160678 GC06P158244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A3 Gene:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for
elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins.
This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded
protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SLC22A3 Gene:
SLC22A3 (solute carrier family 22 (organic cation transporter), member 3) is a protein-coding gene. Diseases associated with SLC22A3 include extragonadal seminoma, and nephropathy-hypertension. GO annotations related to this gene include organic cation transmembrane transporter activity and toxin transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in
the disposition of cationic neurotoxins and neurotransmitters in the brain

Gene Wiki entry for SLC22A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A3 gene promoter:
         MEF-2   Bach2   XBP-1   Ik-3   MEF-2A   Max   aMEF-2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A3 promoter sequence
   Search Chromatin IP Primers for SLC22A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

SLC22A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P160739:  view genomic region     (about GC identifiers)

Start:
160,769,300 bp from pter      End:
160,876,014 bp from pter
Size:
106,715 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751 (See protein sequence)
Recommended Name: Solute carrier family 22 member 3  
Size: 556 amino acids; 61280 Da
Secondary accessions: Q5SYN6 Q9UP02

Explore the universe of human proteins at neXtProt for SLC22A3: NX_O75751

Explore proteomics data for SLC22A3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn72, Asn99, Asn119, Asn322

  • See SLC22A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068812.1  
    ENSEMBL proteins: 
     ENSP00000275300   ENSP00000375989  
    Reactome Protein details: O75751

    SLC22A3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC22A3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC22A3
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    Abcam antibodies for SLC22A3
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    LSBio Antibodies in human, mouse, rat for SLC22A3

    SLC22A3 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic cation transporter 3
    Organic cation transporters (OCT)

    5 InterPro protein domains:
     IPR004749 Orgcat_transp
     IPR011701 MFS
     IPR005829 Sugar_transporter_CS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O75751

    ProtoNet protein and cluster: O75751

    1 Blocks protein domain: IPB005829 Sugar transporter superfamily

    UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    SLC22A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22A3_HUMAN, O75751
    Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in
    the disposition of cationic neurotoxins and neurotransmitters in the brain

         Genatlas biochemistry entry for SLC22A3:
    solute carrier family 22,member A3,polyspecific transporter of organic cations,most abundantly expressed in the
    placenta and moderatly in the intestine,heart and brain,clustered with SLC22A1 and SLC22A2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005329dopamine transmembrane transporter activity IEA--
    GO:0005515protein binding IPI17474147
    GO:0015075ion transmembrane transporter activity ----
    GO:0015101organic cation transmembrane transporter activity IDA10966924
    GO:0015651quaternary ammonium group transmembrane transporter activity IDA10966924
         
    SLC22A3 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc22a3):
     behavior/neurological  cardiovascular system  cellular  growth/size/body  homeostasis/metabolism 
     mortality/aging  nervous system  reproductive system 

    SLC22A3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc22a3tm1Dpb for SLC22A3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC22A3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC22A3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC22A3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC22A3

    miRNA
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    miRTarBase miRNAs that target SLC22A3:
    hsa-mir-9-5p (MIRT021441), hsa-mir-124-3p (MIRT022967), hsa-mir-148b-3p (MIRT019444)

    Block miRNA regulation of human, mouse, rat SLC22A3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC22A3 (see all 27):
    hsa-miR-142-5p hsa-miR-320a hsa-miR-539 hsa-miR-188-5p hsa-miR-513c hsa-miR-624 hsa-miR-29b-1* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22A3_HUMAN, O75751: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9933568
    GO:0016020membrane TAS9933568
    GO:0016021integral component of membrane ----

    SLC22A3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC22A3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Organic cation transport0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Abacavir transport and metabolism
    Abacavir transport and metabolism
    Abacavir transmembrane transport0.00
    3Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    4Metabolism
    Metabolism0.38
    5Sympathetic Nerve Pathway (Neuroeffector Junction)
    Sympathetic Nerve Pathway (Neuroeffector Junction)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC22A3
        Synaptic Vesicle Pathway

    2 Reactome Pathways for SLC22A3
        Organic cation transport
    Abacavir transmembrane transport

    3 PharmGKB Pathways for SLC22A3
        Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Metformin Pathway, Pharmacokinetics
    Sympathetic Nerve Pathway (Neuroeffector Junction)


    SLC22A3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC22A3: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC22A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SLC22A3 (O757511, 3 ENSP000002753004) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 3, ENSP000003614234EBI-1752674,EBI-375543 I2D: score=1 STRING: ENSP00000361423
    NCK1P163333, ENSP000002889864I2D: score=1 STRING: ENSP00000288986
    ABCB1ENSP000002657244STRING: ENSP00000265724
    ABCG2ENSP000002376124STRING: ENSP00000237612
    PDZD3ENSP000003271074STRING: ENSP00000327107
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006855drug transmembrane transport TAS--
    GO:0015695organic cation transport IDA10966924
    GO:0015697quaternary ammonium group transport IDA10966924
    GO:0015844monoamine transport ----
    GO:0015872dopamine transport IEA--

    SLC22A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A3 (S22A3)

    Selected DrugBank Compounds for SLC22A3 (see all 28)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cimetidine-- 51481-61-9transportersubstrate inhibitor10966924 10385678 9632645 10196521
    DesipramineDemethylimipramine (see all 11)50-47-5transporterinhibitor9830022 10966924 9632645
    ClonidineChlornidinum (see all 6)4205-90-7transporterinhibitor10966924 11191835
    Estradiol17beta oestradiol (see all 7)50-28-2transporterinhibitor9830022 12110607
    GuanidineAminomethanamidine (see all 9)113-00-8transportersubstrate inhibitor10966924 9632645
    Lamivudine-- 134678-17-4transportersubstrate20504255 19141712
    NorepinephrineArterenol (see all 4)51-41-2transportersubstrate inhibitor9830022 10196521
    ProgesteroneCorpus Luteum Hormone (see all 4)57-83-0transporterinhibitor9830022 12110607
    Adefovir DipivoxilAdefovir (see all 7)142340-99-6transportersubstrate10196521
    Agmatine-- 306-60-5transportersubstrate12538837

    Selected Novoseek inferred chemical compound relationships for SLC22A3 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcnu 92.4 16 11181897 (5), 10582663 (5), 11349876 (2), 12525514 (1)
    moxa 89.2 3 12807698 (1), 15028572 (1), 11414662 (1)
    1 methyl 4 phenylpyridinium 85.7 29 8752596 (3), 12675912 (2), 11129104 (1), 16081676 (1) (see all 10)
    tetraethylammonium 71.7 1 10966924 (1)
    agmatine 71.4 5 12538837 (4), 16211406 (1)
    cirazoline 65.5 2 15028572 (1), 11414662 (1)
    desipramine 63.7 6 17727882 (2), 12807698 (1), 15028572 (1), 11414662 (1)
    corticosterone 62.2 7 12411423 (1), 16567367 (1), 12807698 (1), 12657510 (1) (see all 6)
    norepinephrine 61.6 24 15121658 (3), 11694456 (3), 12807698 (3), 17727882 (2) (see all 11)
    moxonidine 56 2 15028572 (1), 11414662 (1)



    SLC22A3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC22A3 gene: 
    NM_021977.3  

    Unigene Cluster for SLC22A3:

    Solute carrier family 22 (extraneuronal monoamine transporter), member 3
    Hs.567337  [show with all ESTs]
    Unigene Representative Sequence: BX640965
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275300 ENST00000392145(uc003qti.3 uc011efx.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC22A3
      QuantiFast Probe-based Assays in human, mouse, rat SLC22A3

    Additional mRNA sequence: 

    AF078749.1 AJ001417.1 AK096980.1 AK125826.1 AK314590.1 BC070300.1 BC144280.1 BX640965.1 

    16 DOTS entries:

    DT.91748447  DT.95162937  DT.100806106  DT.100891418  DT.75115006  DT.95162930  DT.107356  DT.453213 
    DT.75185826  DT.100017645  DT.121324583  DT.100891422  DT.101960044  DT.102839295  DT.91686404  DT.91748451 

    Selected AceView cDNA sequences (see all 76):

    AI537481 CA454231 AI452614 AI829666 CR619195 AF078749 AA460012 AA912636 
    AK096980 BF793289 AI810629 AI610187 BG563449 AI039455 AI240473 AI446340 
    NM_021977 AW022774 CF141401 BM971925 BX506246 BU930244 CD300732 BX422932 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:        -     -                                         -                             -               
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for SLC22A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGCTAATC
    SLC22A3 Expression
    About this image


    SLC22A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Thymus (Hematopoietic System)
             Thymus
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Neural Tube (Nervous System)
             Metencephalon
    SLC22A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567337

    UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
    Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland,
    adrenal gland, kidney and brain cortex. No expression detected in spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC22A3: 
              Drug Transporters in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat SLC22A3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a31 , 5 solute carrier family 22 (organic cation transporter), more1, 5 85(n)1
    87.3(a)1
      17 (8.52 cM)5
    205191  NM_011395.21  NP_035525.11 
     124199725 
    chicken
    (Gallus gallus)
    Aves SLC22A31 solute carrier family 22 (extraneuronal monoamine transporter), more 72.47(n)
    75(a)
      421582  XM_419620.4  XP_419620.4 
    lizard
    (Anolis carolinensis)
    Reptilia SLC22A36
    solute carrier family 22 (organic cation transport...
    66(a)
    1 ↔ 1
    1(211822897-211848883)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1751761 zgc:175176 54.41(n)
    47.84(a)
      797890  NM_001114460.1  NP_001107932.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86543 organic cation porter 38(a)
    (best of 16)
      56F6   --


    ENSEMBL Gene Tree for SLC22A3 (if available)
    TreeFam Gene Tree for SLC22A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A3 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  
    SLC22A132  SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A252  
    14 SIMAP similar genes for SLC22A3 using alignment to 3 protein entries:     S22A3_HUMAN (see all proteins):
    SLC22A1    SLC22A2    SLC22A15    SLC22A5    SLC22A8    SLC22A13
    SLC22A4    SLC22A12    SLC22A16    SLC22A24    SLC22A6    SLC22A10
    SLC22A11    SLC22A7

    SLC22A3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC22A3
    PGOHUM00000243451


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A3 (see all 2134)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs599771171,2
    C--158296640(+) AAAAA-/A/AAA 
            
    CCCAC
    1 -- int11NA 2
    rs30040771,2
    C,F--160767443(+) TATGAT/CAAATG 1 -- us2k1 tfbs34Minor allele frequency- C:0.20CSA WA NA 241
    rs1926210561,2
    C--160767819(+) TCTCTA/GAGCAG 1 -- us2k10--------
    rs5206851,2
    C,F--160767849(+) AAGGGG/ACAGGT 1 -- us2k17Minor allele frequency- A:0.31NA WA EA 366
    rs5208291,2
    C,F,H--160767905(+) AACAGG/TTGATT 1 -- us2k112Minor allele frequency- T:0.50NA WA CSA EA 374
    rs1895613001,2
    --160767933(+) TACACA/TGACAA 1 -- us2k10--------
    rs30040781,2
    C,F--160767990(+) GGAAAA/CGCGTT 1 -- us2k11Minor allele frequency- C:0.17NA 120
    rs1509642241,2
    C--160768124(+) AAGGGA/GTTCCA 1 -- us2k10--------
    rs737825571,2
    C,F--160768176(+) TGTCCC/GCGCCA 1 -- us2k12Minor allele frequency- G:0.04WA 120
    rs1398620701,2
    --160768178(+) TCCCCA/GCCATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC22A3 (160769300 - 160876014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SLC22A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7013n71CNV Gain21882294
    nsv818463CNV Gain17921354
    nsv886810CNV Gain21882294
    esv35098CNV Gain17911159
    essv6642CNV CNV17122850
    essv24539CNV CNV17122850
    dgv2024e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SLC22A3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604842    OMIM disorders: --

    Selected diseases for SLC22A3 (see all 26):    
    About MalaCards
    extragonadal seminoma    nephropathy-hypertension    placental choriocarcinoma    seminoma
    obsessive-compulsive disorder    choriocarcinoma    cholestasis    lung cancer susceptibility
    diabetic nephropathy    choroiditis    bronchiolitis    coronary artery disease
    cervical cancer    ischemia    asthma    cervicitis
    hepatitis c    prostate cancer    cerebritis    prostatitis


    SLC22A3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SLC22A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 44.2 8 10582663 (4), 11349876 (2), 12525514 (1), 8692289 (1)
    tumors 0 4 11181897 (2), 10632359 (1), 11349876 (1)

    Genetic Association Database (GAD): SLC22A3
    Human Genome Epidemiology (HuGE) Navigator: SLC22A3 (28 documents)

    Export disorders for SLC22A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A3 gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with SLC22A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (PubMed id 10966924)1, 2, 7, 9 Wu X.... Ganapathy V. (Am. J. Physiol. 2000)
    2. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. (PubMed id 9933568)1, 2, 3 Verhaagh S.... Zwart R. (Genomics 1999)
    3. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. (PubMed id 9632645)1, 3, 7 Kekuda R....Ganapathy V. (J. Biol. Chem. 1998)
    4. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. (PubMed id 10196521)1, 2, 7 Gruendemann D.... Schoemig E. (Nat. Neurosci. 1998)
    5. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. (PubMed id 19591196)1, 4, 9 Nies A.T....Schaeffeler E. (Hepatology 2009)
    6. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). (PubMed id 12538837)1, 7, 9 Grundemann D.... Schomig E. (J. Pharmacol. Exp. Ther. 2003)
    7. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. (PubMed id 17010131)1, 4, 9 Aoyama N....Ozaki N. (Alcohol. Clin. Exp. Res. 2006)
    8. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PubMed id 22095909)1, 4 Lange C.M....Bochud P.Y. (Hepatology 2012)
    9. Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study. (PubMed id 20717903)1, 4 Wang Y....Lange E.M. (Prostate 2011)
    10. Genetic and clinical correlates of early-outgrowth colony-forming units. (PubMed id 21493818)1, 4 Shaw S.Y....Wang T.J. (Circ Cardiovasc Genet 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6581 HGNC: 10967 AceView: SLC22A3 Ensembl:ENSG00000146477 euGenes: HUgn6581
    ECgene: SLC22A3 H-InvDB: SLC22A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A3 gene:
    Search GeneIP for patents involving SLC22A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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