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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC22A3 Gene

protein-coding   GIFtS: 61
GCID: GC06P160739

Solute Carrier Family 22 (Organic Cation Transporter), Member...

(Previous names: solute carrier family 22 (extraneuronal monoamine transporter),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 22 (Organic Cation Transporter), Member 31 2     EMTH2 3
EMT2 3 5     OCT32 3
Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 31 2     EMT Organic Cation Transporter 32
Extraneuronal Monoamine Transporter2 3     Solute Carrier Family 22 Member 32
Organic Cation Transporter 32 3     

External Ids:    HGNC: 109671   Entrez Gene: 65812   Ensembl: ENSG000001464777   OMIM: 6048425   UniProtKB: O757513   

Export aliases for SLC22A3 gene to outside databases

Previous GC identifers: GC06P160208 GC06P160642 GC06P160678 GC06P158244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC22A3 Gene:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for
elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins.
This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded
protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SLC22A3 Gene: 
SLC22A3 (solute carrier family 22 (organic cation transporter), member 3) is a protein-coding gene. Diseases associated with SLC22A3 include extragonadal seminoma, and placental choriocarcinoma, and among its related super-pathways are Abacavir metabolism and Transmembrane transport of small molecules. GO annotations related to this gene include organic cation transmembrane transporter activity and quaternary ammonium group transmembrane transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in
the disposition of cationic neurotoxins and neurotransmitters in the brain

Gene Wiki entry for SLC22A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC22A3 gene promoter:
         MEF-2   Bach2   XBP-1   Ik-3   MEF-2A   Max   aMEF-2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC22A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

SLC22A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P160739:  view genomic region     (about GC identifiers)

Start:
160,769,300 bp from pter      End:
160,876,014 bp from pter
Size:
106,715 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751 (See protein sequence)
Recommended Name: Solute carrier family 22 member 3  
Size: 556 amino acids; 61280 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5SYN6 Q9UP02

Explore the universe of human proteins at neXtProt for SLC22A3: NX_O75751

Explore proteomics data for SLC22A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75751

  • SLC22A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC22A3 Protein Expression
    REFSEQ proteins: NP_068812.1  
    ENSEMBL proteins: 
     ENSP00000275300   ENSP00000375989  
    Reactome Protein details: O75751
    Human Recombinant Protein Products for SLC22A3: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9933568
    GO:0016020membrane TAS9933568
    GO:0016021integral to membrane ----

    SLC22A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic cation transporter 3 
    Organic cation transporters (OCT)

    5 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR020846 MFS_dom
     IPR004749 Orgcat_transp
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O75751

    ProtoNet protein and cluster: O75751

    1 Blocks protein domain: IPB005829 Sugar transporter superfamily

    UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    SLC22A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22A3_HUMAN, O75751
    Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in
    the disposition of cationic neurotoxins and neurotransmitters in the brain

         Genatlas biochemistry entry for SLC22A3:
    solute carrier family 22,member A3,polyspecific transporter of organic cations,most abundantly expressed in the
    placenta and moderatly in the intestine,heart and brain,clustered with SLC22A1 and SLC22A2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005329dopamine transmembrane transporter activity IEA--
    GO:0005515protein binding IPI17474147
    GO:0015075ion transmembrane transporter activity ----
    GO:0015101organic cation transmembrane transporter activity IDA10966924
    GO:0015651quaternary ammonium group transmembrane transporter activity IDA10966924
         
    SLC22A3 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc22a3):
     behavior/neurological  cardiovascular system  cellular  growth/size  homeostasis/metabolism 
     mortality/aging  nervous system  reproductive system 

    SLC22A3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc22a3tm1Dpb for SLC22A3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC22A3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC22A3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Abacavir transport and metabolism
    Abacavir transport and metabolism0.50
    Metformin Pathway, Pharmacokinetics0.33
    Abacavir transmembrane transport0.50
    2SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    3Organic cation/anion/zwitterion transport
    Organic cation/anion/zwitterion transport0.62
    Organic cation transport0.62
    4Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    5Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC22A3
        Synaptic Vesicle Pathway

    5/8        Reactome Pathways for SLC22A3 (see all 8)
        Transmembrane transport of small molecules
    SLC-mediated transmembrane transport
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metabolism
    Organic cation/anion/zwitterion transport

    3 PharmGKB Pathways for SLC22A3
        Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Metformin Pathway, Pharmacokinetics
    Sympathetic Nerve Pathway (Neuroeffector Junction)


    SLC22A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC22A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLC22A3 (O757511, 3 ENSP000002753004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 3, ENSP000003614234EBI-1752674,EBI-375543 I2D: score=1 STRING: ENSP00000361423
    NCK1P163333, ENSP000002889864I2D: score=1 STRING: ENSP00000288986
    ABCB1ENSP000002657244STRING: ENSP00000265724
    ABCG2ENSP000002376124STRING: ENSP00000237612
    PDZD3ENSP000003271074STRING: ENSP00000327107
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006855drug transmembrane transport TAS--
    GO:0015695organic cation transport IDA10966924
    GO:0015697quaternary ammonium group transport IDA10966924
    GO:0015844monoamine transport ----
    GO:0015872dopamine transport IEA--

    SLC22A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC22A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC22A3 (S22A3)

    10/28 DrugBank Compounds for SLC22A3 (see all 28)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cimetidine-- 51481-61-9transportersubstrate inhibitor10966924 10385678 9632645 10196521
    DesipramineDemethylimipramine (see all 11)50-47-5transporterinhibitor9830022 10966924 9632645
    ClonidineChlornidinum (see all 6)4205-90-7transporterinhibitor10966924 11191835
    Estradiol17beta oestradiol (see all 7)50-28-2transporterinhibitor9830022 12110607
    GuanidineAminomethanamidine (see all 9)113-00-8transportersubstrate inhibitor10966924 9632645
    Lamivudine-- 134678-17-4transportersubstrate20504255 19141712
    NorepinephrineArterenol (see all 4)51-41-2transportersubstrate inhibitor9830022 10196521
    ProgesteroneCorpus Luteum Hormone (see all 4)57-83-0transporterinhibitor9830022 12110607
    Adefovir DipivoxilAdefovir (see all 7)142340-99-6transportersubstrate10196521
    Agmatine-- 306-60-5transportersubstrate12538837

    10/28 Novoseek inferred chemical compound relationships for SLC22A3 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcnu 92.4 16 11181897 (5), 10582663 (5), 11349876 (2), 12525514 (1)
    moxa 89.2 3 12807698 (1), 15028572 (1), 11414662 (1)
    1 methyl 4 phenylpyridinium 85.7 29 8752596 (3), 12675912 (2), 11129104 (1), 16081676 (1) (see all 10)
    tetraethylammonium 71.7 1 10966924 (1)
    agmatine 71.4 5 12538837 (4), 16211406 (1)
    cirazoline 65.5 2 15028572 (1), 11414662 (1)
    desipramine 63.7 6 17727882 (2), 12807698 (1), 15028572 (1), 11414662 (1)
    corticosterone 62.2 7 12411423 (1), 16567367 (1), 12807698 (1), 12657510 (1) (see all 6)
    norepinephrine 61.6 24 15121658 (3), 11694456 (3), 12807698 (3), 17727882 (2) (see all 11)
    moxonidine 56 2 15028572 (1), 11414662 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC22A3 / S22A3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for SLC22A3 gene: 
    NM_021977.3  

    Unigene Cluster for SLC22A3:

    Solute carrier family 22 (extraneuronal monoamine transporter), member 3
    Hs.567337  [show with all ESTs]
    Unigene Representative Sequence: BX640965
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275300 ENST00000392145(uc003qti.3 uc011efx.2)
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    Additional mRNA sequence: 

    AF078749.1 AJ001417.1 AK096980.1 AK125826.1 AK314590.1 BC070300.1 BC144280.1 BX640965.1 

    16 DOTS entries:

    DT.91748447  DT.95162937  DT.100806106  DT.100891418  DT.75115006  DT.95162930  DT.107356  DT.453213 
    DT.75185826  DT.100017645  DT.121324583  DT.100891422  DT.101960044  DT.102839295  DT.91686404  DT.91748451 

    24/76 AceView cDNA sequences (see all 76):

    NM_021977 AI039455 AI810629 AI240473 AI610187 CA454231 BF793289 AA460012 
    AI829666 CR619195 AK096980 AI446340 BG563449 AF078749 AI452614 AI537481 
    AA912636 CB963661 BU681689 BX102816 BF090038 BX640965 AA583544 BU930244 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:        -     -                                         -                             -               
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for SLC22A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC22A3 expression in normal human tissues (normalized intensities)      SLC22A3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGCTAATC
    SLC22A3 Expression
    About this image


    SLC22A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Thymus (Hematopoietic System)
             Thymus
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Chorion (Extraembryonic Tissues)
             Human Chorionic Mesenchymal Stromal Cells (HCMSC)   

    See SLC22A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC22A3

    SOURCE GeneReport for Unigene cluster: Hs.567337

    UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
    Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland,
    adrenal gland, kidney and brain cortex. No expression detected in spleen

        SABiosciences Expression via Pathway-Focused PCR Array including SLC22A3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a31 , 5 solute carrier family 22 (organic cation transporter), more1, 5 85.19(n)1
    87.61(a)1
      17 (8.52 cM)5
    205191  NM_011395.21  NP_035525.11 
     124199725 
    chicken
    (Gallus gallus)
    Aves SLC22A31 solute carrier family 22 (extraneuronal monoamine transporter), more 72(n)
    75.2(a)
      421582  XM_419620.3  XP_419620.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC22A36
    solute carrier family 22 (extraneuronal monoamine ...
    66(a)
    1 ↔ 1
    1(211822897-211848883)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1751761 zgc:175176 54.86(n)
    48.38(a)
      797890  NM_001114460.1  NP_001107932.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86543 organic cation porter 38(a)
    (best of 16)
      56F6   --
    worm
    (Caenorhabditis elegans)
    Secernentea oct-13 transporter 29(a)
    (best of 7)
      I(9896504-9899565)   --


    ENSEMBL Gene Tree for SLC22A3 (if available)
    TreeFam Gene Tree for SLC22A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC22A3 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  
    SLC22A132  SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A252  
    14 SIMAP similar genes for SLC22A3 using alignment to 3 protein entries:     S22A3_HUMAN (see all proteins):
    SLC22A1    SLC22A2    SLC22A15    SLC22A5    SLC22A8    SLC22A13
    SLC22A4    SLC22A12    SLC22A16    SLC22A24    SLC22A6    SLC22A10
    SLC22A11    SLC22A7

    SLC22A3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC22A3
    PGOHUM00000243451


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2134 SNPs in SLC22A3 are shown (see all 2134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs599771171,2
    C--158296640(+) AAAAA-/A/AAA 
            
    CCCAC
    1 -- int11NA 2
    rs30040771,2
    C,F--160767443(+) TATGAT/CAAATG 1 -- us2k1 tfbs34Minor allele frequency- C:0.20CSA WA NA 241
    rs1926210561,2
    C--160767819(+) TCTCTA/GAGCAG 1 -- us2k10--------
    rs5206851,2
    C,F--160767849(+) AAGGGG/ACAGGT 1 -- us2k17Minor allele frequency- A:0.31NA WA EA 366
    rs5208291,2
    C,F,H--160767905(+) AACAGG/TTGATT 1 -- us2k112Minor allele frequency- T:0.50NA WA CSA EA 374
    rs1895613001,2
    --160767933(+) TACACA/TGACAA 1 -- us2k10--------
    rs30040781,2
    C,F--160767990(+) GGAAAA/CGCGTT 1 -- us2k11Minor allele frequency- C:0.17NA 120
    rs1509642241,2
    C--160768124(+) AAGGGA/GTTCCA 1 -- us2k10--------
    rs737825571,2
    C,F--160768176(+) TGTCCC/GCGCCA 1 -- us2k12Minor allele frequency- G:0.04WA 120
    rs1398620701,2
    --160768178(+) TCCCCA/GCCATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC22A3 (160769300 - 160876014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SLC22A3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv7013n71CNV Gain21882294
    nsv818463CNV Gain17921354
    nsv886810CNV Gain21882294
    esv35098CNV Gain17911159
    essv6642CNV CNV17122850
    essv24539CNV CNV17122850
    dgv2024e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): SLC22A3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604842    OMIM disorders: --

    20 diseases for SLC22A3:    About MalaCards
    extragonadal seminoma    placental choriocarcinoma    obsessive-compulsive disorder    choriocarcinoma
    seminoma    cholestasis    choroiditis    ischemia
    asthma    cervical cancer    colon cancer    prostate cancer
    cerebritis    hepatitis c    prostatitis    cervicitis
    colorectal cancer    lung cancer    neuronitis    hepatitis


    SLC22A3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SLC22A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 44.2 8 10582663 (4), 11349876 (2), 12525514 (1), 8692289 (1)
    tumors 0 4 11181897 (2), 10632359 (1), 11349876 (1)

    Genetic Association Database (GAD): SLC22A3
    Human Genome Epidemiology (HuGE) Navigator: SLC22A3 (28 documents)

    Export disorders for SLC22A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC22A3 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with SLC22A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (PubMed id 10966924)1, 2, 7, 9 Wu X.... Ganapathy V. (2000)
    2. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. (PubMed id 9933568)1, 2, 3 Verhaagh S.... Zwart R. (1999)
    3. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. (PubMed id 9632645)1, 3, 7 Kekuda R....Ganapathy V. (1998)
    4. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. (PubMed id 10196521)1, 2, 7 Gruendemann D.... Schoemig E. (1998)
    5. Expression of organic cation transporters OCT1 (SLC22 A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. (PubMed id 19591196)1, 4, 9 Nies A.T....Schaeffeler E. (2009)
    6. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). (PubMed id 12538837)1, 7, 9 Grundemann D....Schomig E. (2003)
    7. Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. (PubMed id 17010131)1, 4, 9 Aoyama N....Ozaki N. (2006)
    8. Serum ferritin levels are associated with a distinct p henotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PubMed id 22095909)1, 4 Lange C.M....Bochud P.Y. (2012)
    9. Genetic and clinical correlates of early-outgrowth co lony-forming units. (PubMed id 21493818)1, 4 Shaw S.Y....Wang T.J. (2011)
    10. Meta-analysis of genome-wide and replication associat ion studies on prostate cancer. (PubMed id 20690139)1, 4 Liu H....Han C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6581 HGNC: 10967 AceView: SLC22A3 Ensembl:ENSG00000146477 euGenes: HUgn6581
    ECgene: SLC22A3 H-InvDB: SLC22A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC22A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC22A3 gene:
    Search GeneIP for patents involving SLC22A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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