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GIFtS

SLC22A3 Gene

protein-coding   GIFtS: 61
GCID: GC06P160739

solute carrier family 22 (extraneuronal monoamine transporter),...
 Explore 16 diseases affiliated with
SLC22A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC22A3    

Aliases
for SLC22A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 22 (Extraneuronal Monoamine Transporter), Member 31 2     Organic Cation Transporter 32 3
EMT1 2 3 5     EMTH2 3
OCT31 2 3     EMT Organic Cation Transporter 32
Extraneuronal Monoamine Transporter2 3     Solute Carrier Family 22 Member 32

External Ids:    HGNC: 109671   Entrez Gene: 65812   Ensembl: ENSG000001464777   OMIM: 6048425   UniProtKB: O757513   

Export aliases for SLC22A3 gene to outside databases

Previous GC identifers: GC06P160208 GC06P160642 GC06P160678 GC06P158244


Summaries
for SLC22A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC22A3:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination
of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one
of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve
putative transmembrane domains and is a plasma integral membrane protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the
disposition of cationic neurotoxins and neurotransmitters in the brain

Gene Wiki entry for SLC22A3


Genomic Views
for SLC22A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC22A3 gene promoter:
         MEF-2   Bach2   XBP-1   Ik-3   MEF-2A   Max   aMEF-2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC22A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC22A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

SLC22A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P160739:  view genomic region     (about GC identifiers)

Start:
 160,769,300 bp from pter      End:
 160,876,014 bp from pter
Size:
 106,715 bases      Orientation:
 plus strand

Proteins
for SLC22A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751 (See protein sequence)
Recommended Name: Solute carrier family 22 member 3  
Size: 556 amino acids; 61280 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5SYN6 Q9UP02

Explore the universe of human proteins at neXtProt for SLC22A3: NX_O75751

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75751

    • SLC22A3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_068812.1  
    ENSEMBL proteins: 
     ENSP00000275300   ENSP00000375989  
    Reactome Protein details: O75751
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC22A3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9933568
    GO:0016020membrane TAS9933568
    GO:0016021integral to membrane ----


    SLC22A3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLC22A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC22A3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR005829 Sugar_transporter_CS
     IPR020846 MFS_dom
     IPR004749 Orgcat_transp
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O75751

    ProtoNet protein and cluster: O75751

    1 Blocks protein family: IPB005829 Sugar transporter superfamily

    UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family


    Function
    for SLC22A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
    Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the
    disposition of cationic neurotoxins and neurotransmitters in the brain

         Genatlas biochemistry entry for SLC22A3:
    solute carrier family 22,member A3,polyspecific transporter of organic cations,most abundantly expressed in the
    placenta and moderatly in the intestine,heart and brain,clustered with SLC22A1 and SLC22A2

    miRNA
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    hsa-miR-142-5p hsa-miR-320a hsa-miR-539 hsa-miR-188-5p hsa-miR-513c hsa-miR-624 hsa-miR-29b-1* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: SLC22A3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005329dopamine transmembrane transporter activity IEA--
    GO:0005515protein binding IPI17474147
    GO:0015075ion transmembrane transporter activity ----
    GO:0015101organic cation transmembrane transporter activity IDA16024787
    GO:0015651quaternary ammonium group transmembrane transporter activity IDA10966924


    SLC22A3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Slc22a3tm1Dpb for SLC22A3
         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc22a3):
     behavior/neurological  cardiovascular system  cellular  growth/size  homeostasis/metabolism 
     mortality/aging  nervous system  reproductive system 

    SLC22A3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC22A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Abacavir transport and metabolism
    		Abacavir transport and metabolism1.00
    		Metformin Pathway, Pharmacokinetics0.21
    		Abacavir transmembrane transport0.50
    3Organic cation/anion/zwitterion transport
    		Organic cation/anion/zwitterion transport1.00
    		Organic cation transport0.62
    4Metabolism
    		Metabolism1.00
    5Sympathetic Nerve Pathway (Neuroeffector Junction)
    		Sympathetic Nerve Pathway (Neuroeffector Junction)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SLC22A3 
        Synaptic Vesicle Pathway

    5/8        Reactome Pathways for SLC22A3 (see all 8)
        Transmembrane transport of small molecules
    SLC-mediated transmembrane transport
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metabolism
    Organic cation/anion/zwitterion transport

    3 PharmGKB Pathways for SLC22A3
        Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Metformin Pathway, Pharmacokinetics
    Sympathetic Nerve Pathway (Neuroeffector Junction)


    SLC22A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC22A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLC22A3 (O757511, 3 ENSP000002753004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 3, ENSP000003614234EBI-1752674,EBI-1550796 I2D: score=1 STRING: ENSP00000361423
    NCK1P163333, ENSP000002889864I2D: score=1 STRING: ENSP00000288986
    ABCB1ENSP000002657244STRING: ENSP00000265724
    ABCG2ENSP000002376124STRING: ENSP00000237612
    PDZD3ENSP000003271074STRING: ENSP00000327107
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006855drug transmembrane transport TAS--
    GO:0015695organic cation transport IDA16024787
    GO:0015697quaternary ammonium group transport IDA10966924
    GO:0015844monoamine transport ----
    GO:0015872dopamine transport IEA--


    SLC22A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC22A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC22A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC22A3

    10/25 DrugBank Compounds for SLC22A3 (see all 25)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cimetidine-- 51481-61-9transportersubstrate inhibitor10966924 10385678 9632645 10196521
    DesipramineDemethylimipramine (see all 12)50-47-5transporterinhibitor9830022 10966924 9632645
    ClonidineChlornidinum (see all 6)4205-90-7transporterinhibitor10966924 11191835
    Estradiol17beta oestradiol (see all 7)50-28-2transporterinhibitor9830022 12110607
    GuanidineAminomethanamidine (see all 9)113-00-8transportersubstrate inhibitor10966924 9632645
    NorepinephrineArterenol (see all 4)51-41-2transportersubstrate inhibitor9830022 10196521
    ProgesteroneCorpus Luteum Hormone (see all 4)57-83-0transporterinhibitor9830022 12110607
    Adefovir DipivoxilAdefovir (see all 7)142340-99-6transportersubstrate10196521
    Amphetamine(+/-)-Benzedrine (see all 19)300-62-9transporterinhibitor9830022
    CholineBilineurine (see all 7)62-49-7transporterinhibitor9632645

    10/28 Novoseek chemical compound relationships for SLC22A3 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcnu 92.4 16 11181897 (5), 10582663 (5), 11349876 (2), 12525514 (1)
    moxa 89.2 3 12807698 (1), 15028572 (1), 11414662 (1)
    1 methyl 4 phenylpyridinium 85.7 29 8752596 (3), 12675912 (2), 11129104 (1), 16081676 (1) (see all 10)
    tetraethylammonium 71.7 1 10966924 (1)
    agmatine 71.4 5 12538837 (4), 16211406 (1)
    cirazoline 65.5 2 15028572 (1), 11414662 (1)
    desipramine 63.7 6 17727882 (2), 12807698 (1), 15028572 (1), 11414662 (1)
    corticosterone 62.2 7 12411423 (1), 16567367 (1), 12807698 (1), 12657510 (1) (see all 6)
    norepinephrine 61.6 24 15121658 (3), 11694456 (3), 12807698 (3), 17727882 (2) (see all 11)
    moxonidine 56 2 15028572 (1), 11414662 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC22A3 / S22A3 

    Transcripts
    for SLC22A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for SLC22A3 gene: 
    NM_021977.3  

    Unigene Cluster for SLC22A3:

    Solute carrier family 22 (extraneuronal monoamine transporter), member 3
    Hs.567337  [show with all ESTs]
    Unigene Representative Sequence: BX640965
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000275300 ENST00000392145(uc003qti.3 uc011efx.2)

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF078749.1 AJ001417.1 AK096980.1 AK125826.1 AK314590.1 BC070300.1 BC144280.1 BX640965.1 

    12 DOTS entries:

    DT.91748447  DT.95162937  DT.100806106  DT.100891418  DT.75115006  DT.95162930  DT.107356  DT.75185826 
    DT.100017645  DT.101960044  DT.102839295  DT.121324583 

    24/76 AceView cDNA sequences (see all 76):

    CA454231 AI240473 AI537481 CR619195 AI039455 AI446340 BF793289 BG563449 
    AI452614 AK096980 AI610187 NM_021977 AI810629 AA460012 AI829666 AA912636 
    AF078749 AA703015 AA583544 BX102816 BF090010 BX410218 AW021523 AA043225 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:        -     -                                         -                             -               
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for SLC22A3

    Expression
    for SLC22A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC22A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCGCTAATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC22A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See SLC22A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC22A3

    SOURCE GeneReport for Unigene cluster: Hs.567337

    UniProtKB/Swiss-Prot: S22A3_HUMAN, O75751
    Tissue specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal
    gland, kidney and brain cortex. No expression detected in spleen

        SABiosciences Expression via Pathway-Focused PCR Array including SLC22A3: 
              Drug Transporters in human mouse rat

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    In Situ
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    Orthologs
    for SLC22A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A3 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC22A31 solute carrier family 22 (extraneuronal monoamine transporter), more 72(n)
    75.2(a)    		   421582  XM_419620.3  XP_419620.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC22A36
    		 --
    		 66(a)
    		 1 ↔ 1
    		 1(211818613-211848589)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1751761 zgc:175176 54.86(n)
    48.38(a)    		   797890  NM_001114460.1  NP_001107932.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG86543 organic cation porter 38(a)
    (best of 16)    		   56F6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea oct-13 transporter 29(a)
    (best of 7)    		   I(9896504-9899565)   --


    ENSEMBL Gene Tree for SLC22A3 (if available)
    TreeFam Gene Tree for SLC22A3 (if available) 

    Paralogs
    for SLC22A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC22A3 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A92  
    SLC22A102  SLC22A132  SLC22A62  SLC22A152  SLC22A72  SLC22A122  SLC22A162  SLC22A252  
    15 SIMAP similar genes for SLC22A3 using alignment to 3 protein entries:     S22A3_HUMAN (see all proteins):
    SLC22A1    SLC22A2    SLC22A15    SLC22A5    SLC22A8    SLC22A13
    SLC22A4    SLC22A12    SLC22A16    SLC22A24    SLC22A6    SLC22A10
    SLC22A11    SLC22A7    SLC22A20

    SLC22A3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC22A3
    PGOHUM00000243451


    Genomic Variants
    for SLC22A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1775 NCBI SNPs in SLC22A3 are shown (see all 1775)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs30040771,2
    		C,--160767443(+) TATGAT/CAAATG 1 -- us2k1 tfbs34Minor allele frequency- C:0.20CSA WA NA 241
    rs1926210561,2
    		C,--160767819(+) TCTCTA/GAGCAG 1 -- us2k10--------
    rs5206851,2
    		C,F,--160767849(+) AAGGGG/ACAGGT 1 -- us2k17Minor allele frequency- A:0.31NA WA EA 366
    rs5208291,2
    		C,F,H,--160767905(+) AACAGG/TTGATT 1 -- us2k112Minor allele frequency- T:0.50NA WA CSA EA 374
    rs1895613001,2
    		--160767933(+) TACACA/TGACAA 1 -- us2k10--------
    rs30040781,2
    		C,F,--160767990(+) GGAAAA/CGCGTT 1 -- us2k11Minor allele frequency- C:0.17NA 120
    rs1509642241,2
    		--160768124(+) AAGGGA/GTTCCA 1 -- us2k10--------
    rs737825571,2
    		C,--160768176(+) TGTCCC/GCGCCA 1 -- us2k12Minor allele frequency- G:0.04WA 120
    rs1398620701,2
    		--160768178(+) TCCCCA/GCCATA 1 -- us2k10--------
    rs104557811,2
    		--160768212(+) GGACAC/TGGTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC22A3 (160769300 - 160876014 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SLC22A3
         4 CNVs: 8530 3648 9552 2661
    Human Gene Mutation Database (HGMD): SLC22A3

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    Disorders / Diseases
    for SLC22A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC22A3 for disorders           About GeneDecksing

    OMIM gene information: 604842    OMIM disorders: --

    16 diseases for SLC22A3:    About MalaCards
    obsessive-compulsive disorder    placental choriocarcinoma    choriocarcinoma    cholestasis
    nephropathy    prostate cancer    choroiditis    colon cancer
    colorectal cancer    lung cancer    prostatitis    ischemia
    asthma    cerebritis    neuronitis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for SLC22A3:
    Extragonadal seminoma

    2 Novoseek disease relationships for SLC22A3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 44.2 8 10582663 (4), 11349876 (2), 12525514 (1), 8692289 (1)
    tumors 0 4 11181897 (2), 10632359 (1), 11349876 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC22A3 (28 documents)

    Export disorders for SLC22A3 gene to outside databases

    Publications
    for SLC22A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC22A3 gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with SLC22A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. (PubMed id 10966924)1, 2, 7, 9 Wu X.... Ganapathy V. (2000)
    2. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. (PubMed id 9933568)1, 2, 3 Verhaagh S.... Zwart R. (1999)
    3. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. (PubMed id 9632645)1, 3, 7 Kekuda R....Ganapathy V. (1998)
    4. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. (PubMed id 10196521)1, 2, 7 Gruendemann D.... Schoemig E. (1998)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. (PubMed id 12110607)1, 7 Hayer-Zillgen M....Bonisch H. (2002)
    7. Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. (PubMed id 9830022)1, 7 Wu X....Ganapathy V. (1998)
    8. Expression of organic cation transporters OCT1 (SLC22 A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. (PubMed id 19591196)1, 9 Nies A.T....Schaeffeler E. (2009)
    9. Caki-1 cells as a model system for the interaction of renally secreted drugs with OCT3. (PubMed id 18253050)1, 9 Glube N. and Langguth P. (2008)
    10. Analysis of the gene structure of the human (SLC22A3) and murine (Slc22a3) extraneuronal monoamine transporter. (PubMed id 11129104)1, 9 Wieland A.... Bruss M. (2000)

    External Searches for SLC22A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing SLC22A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6581 HGNC: 10967 AceView: SLC22A3 Ensembl:ENSG00000146477 euGenes: HUgn6581
    ECgene: SLC22A3 H-InvDB: SLC22A3

    Other Databases showing SLC22A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC22A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC22A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC22A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC22A3 gene:
    Search GeneIP for patents involving SLC22A3

    GeneCards and IP:
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