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Aliases for SLC22A25 Gene

Aliases for SLC22A25 Gene

  • Solute Carrier Family 22 Member 25 2 3 5
  • MGI:2442751, MGI:2385316, MGI:3042283, MGI:3645714, MGI:3605624, MGI:2442750 2 3
  • Organic Anion Transporter UST6 3 4
  • UST6 3 4
  • Putative UST1-Like Organic Anion Transporter 3
  • Solute Carrier Family 22, Member 25 2
  • HIMTP 3

External Ids for SLC22A25 Gene

Previous GeneCards Identifiers for SLC22A25 Gene

  • GC11M062688
  • GC11M062931
  • GC11M059260

Summaries for SLC22A25 Gene

GeneCards Summary for SLC22A25 Gene

SLC22A25 (Solute Carrier Family 22 Member 25) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A9.

Gene Wiki entry for SLC22A25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A25 Gene

Genomics for SLC22A25 Gene

Regulatory Elements for SLC22A25 Gene

Enhancers for SLC22A25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G063243 0.8 FANTOM5 21.3 -0.2 -215 0.7 BCOR TAF1 ZMYM3 MAX YY1 JUND ATF3 GATA2 FOS HNF4A SLC22A10 SLC22A25 SLC22A9 SLC22A24 LOC105369334
GH11G063245 0.9 dbSUPER 9.5 -4.0 -4024 3.3 TBP FOXA2 ZBTB40 RARA YY1 GATA2 CREM MIXL1 SP5 CEBPA SLC22A8 SLC22A9 SLC22A25 LOC105369334
GH11G063249 1 dbSUPER 7.5 -7.4 -7391 2.8 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 GATA2 FOS SP5 MXD4 SLC22A10 SLC22A25 LOC105369334
GH11G063179 0.5 ENCODE 10.3 +63.8 63815 0.5 GATA3 NFE2 FOS SLC22A25 SLC22A24 GC11M063173
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC22A25 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A25 Gene

Chromosome:
11
Start:
63,162,266 bp from pter
End:
63,243,516 bp from pter
Size:
81,251 bases
Orientation:
Minus strand

Genomic View for SLC22A25 Gene

Genes around SLC22A25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A25 Gene

Proteins for SLC22A25 Gene

  • Protein details for SLC22A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6T423-S22AP_HUMAN
    Recommended name:
    Solute carrier family 22 member 25
    Protein Accession:
    Q6T423
    Secondary Accessions:
    • A4FU27

    Protein attributes for SLC22A25 Gene

    Size:
    547 amino acids
    Molecular mass:
    61008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A25 Gene

Post-translational modifications for SLC22A25 Gene

  • Glycosylation at Asn56 and isoforms=102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A25 Gene

Domains & Families for SLC22A25 Gene

Gene Families for SLC22A25 Gene

HGNC:
IUPHAR :

Protein Domains for SLC22A25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A25 Gene

Graphical View of Domain Structure for InterPro Entry

Q6T423

UniProtKB/Swiss-Prot:

S22AP_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A25: view

Function for SLC22A25 Gene

Gene Ontology (GO) - Molecular Function for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0015143 urate transmembrane transporter activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC22A25: view
genes like me logo Genes that share phenotypes with SLC22A25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A25 Gene

Localization for SLC22A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A25 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A25 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A25: view

Pathways & Interactions for SLC22A25 Gene

SuperPathways for SLC22A25 Gene

No Data Available

Interacting Proteins for SLC22A25 Gene

Gene Ontology (GO) - Biological Process for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015747 urate transport IBA --
GO:0043252 sodium-independent organic anion transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A25: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A25 Gene

Transcripts for SLC22A25 Gene

Unigene Clusters for SLC22A25 Gene

Solute carrier family 22, member 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1:
SP2: - - - - -
SP3: - -
SP4: - - - - - - -

Relevant External Links for SLC22A25 Gene

GeneLoc Exon Structure for
SLC22A25
ECgene alternative splicing isoforms for
SLC22A25

Expression for SLC22A25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A25 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A25 Gene

This gene is overexpressed in Liver (x50.1).

Protein differential expression in normal tissues from HIPED for SLC22A25 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A25 Gene



Protein tissue co-expression partners for SLC22A25 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC22A25 Gene:

SLC22A25

SOURCE GeneReport for Unigene cluster for SLC22A25 Gene:

Hs.332119

mRNA Expression by UniProt/SwissProt for SLC22A25 Gene:

Q6T423-S22AP_HUMAN
Tissue specificity: Expressed exclusively in liver in both embryo and adult.

Evidence on tissue expression from TISSUES for SLC22A25 Gene

  • Liver(2.3)
genes like me logo Genes that share expression patterns with SLC22A25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A25 Gene

Orthologs for SLC22A25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A25 34 35
  • 98.62 (n)
mouse
(Mus musculus)
Mammalia Slc22a30 34 16 35
  • 69.53 (n)
Slc22a19 35
  • 55 (a)
ManyToMany
Slc22a27 35
  • 55 (a)
ManyToMany
Slc22a28 35
  • 55 (a)
ManyToMany
Slc22a29 35
  • 55 (a)
ManyToMany
Slc22a26 35
  • 52 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 69 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ust5r 34
  • 68.86 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
Species where no ortholog for SLC22A25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC22A25 Gene

ENSEMBL:
Gene Tree for SLC22A25 (if available)
TreeFam:
Gene Tree for SLC22A25 (if available)

Paralogs for SLC22A25 Gene

Pseudogenes.org Pseudogenes for SLC22A25 Gene

genes like me logo Genes that share paralogs with SLC22A25: view

Variants for SLC22A25 Gene

Sequence variations from dbSNP and Humsavar for SLC22A25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000040877 -- 63,195,278(+) CTCTC(C/T)ACCCC intron-variant
rs1000064689 -- 63,231,599(+) GGTTG(C/T)CTGTT intron-variant, upstream-variant-2KB
rs1000092681 -- 63,210,849(+) AAAAA(A/G)TACAG intron-variant
rs1000097175 -- 63,232,334(+) TCCTT(A/G)AAGAG intron-variant
rs1000132225 -- 63,185,109(+) AATTT(C/T)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A25 Gene

Variant ID Type Subtype PubMed ID
esv2744609 CNV deletion 23290073
esv33721 CNV loss 17666407
esv34011 CNV loss 18971310
esv3626627 CNV loss 21293372
esv3626629 CNV loss 21293372
nsv555177 CNV loss 21841781

Variation tolerance for SLC22A25 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.76; 93.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A25 Gene

Human Gene Mutation Database (HGMD)
SLC22A25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A25 Gene

Disorders for SLC22A25 Gene

Relevant External Links for SLC22A25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A25

No disorders were found for SLC22A25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A25 Gene

Publications for SLC22A25 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 2 3 64
  2. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. (PMID: 15054140) Eraly S.A. … Nigam S.K. (Physiol. Genomics 2004) 3 4 64
  3. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. (PMID: 18466105) ZaA^r Z.M. … Kullak-Ublick G.A. (Pharmacogenomics 2008) 3 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for SLC22A25 Gene

Sources for SLC22A25 Gene

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