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SLC22A25 Gene

protein-coding   GIFtS: 46
GCID: GC11M062931

Solute Carrier Family 22, Member 25

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22, Member 251 2
UST62 3 5
Organic Anion Transporter UST62 3
HIMTP2
Putative UST1-Like Organic Anion Transporter2
Solute Carrier Family 22 Member 252

External Ids:    HGNC: 329351   Entrez Gene: 3876012   Ensembl: ENSG000001966007   OMIM: 6107925   UniProtKB: Q6T4233   

Export aliases for SLC22A25 gene to outside databases

Previous GC identifers: GC11M062688 GC11M059260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC22A25 Gene:
SLC22A25 (solute carrier family 22, member 25) is a protein-coding gene. An important paralog of this gene is SLC22A11.

Gene Wiki entry for SLC22A25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A25 gene promoter:
         Pax-5   GCNF   Pax-6   E4BP4   Pax-3   FAC1   PPAR-gamma1   GCNF-1   PPAR-gamma2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A25 promoter sequence
   Search Chromatin IP Primers for SLC22A25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

SLC22A25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A25 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062931:  view genomic region     (about GC identifiers)

Start:
62,931,248 bp from pter      End:
62,997,124 bp from pter
Size:
65,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S22AP_HUMAN, Q6T423 (See protein sequence)
Recommended Name: Solute carrier family 22 member 25  
Size: 547 amino acids; 61008 Da
Secondary accessions: A4FU27

Explore the universe of human proteins at neXtProt for SLC22A25: NX_Q6T423

Explore proteomics data for SLC22A25 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56, Asn102
  • Modification sites at PhosphoSitePlus

  • See SLC22A25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_955384.3  
    ENSEMBL proteins: 
     ENSP00000307443   ENSP00000432242   ENSP00000431235   ENSP00000435614   ENSP00000384208  

    SLC22A25 Human Recombinant Protein Products:

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    antibodies-online peptides for SLC22A25

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    antibodies-online kits for SLC22A25 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: UST6
    Orphan or poorly characterized SLC22 family members

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q6T423

    ProtoNet protein and cluster: Q6T423

    UniProtKB/Swiss-Prot: S22AP_HUMAN, Q6T423
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC22A25           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC22A25

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22AP_HUMAN, Q6T423: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC22A25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A25
    Interactions:

        Search GeneGlobe Interaction Network for SLC22A25

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055085transmembrane transport IEA--

    Find genes that share ontologies with SLC22A25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A25 (S22AP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A25 gene: 
    NM_199352.3  

    Unigene Cluster for SLC22A25:

    Solute carrier family 22, member 25
    Hs.332119  [show with all ESTs]
    Unigene Representative Sequence: BC101314
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306494(uc001nwr.1) ENST00000527057 ENST00000528239(uc009yoq.1 uc001nws.1 uc001nwt.1)
    ENST00000525295 ENST00000403374
    miRNA
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    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC22A25
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC22A25
      QuantiFast Probe-based Assays in human, mouse, rat SLC22A25

    Additional mRNA sequence: 

    AK091990.1 AK127610.1 AY437532.1 AY517500.1 BC101314.2 BC101315.1 BC101316.1 BC101317.1 

    6 DOTS entries:

    DT.40113328  DT.120717923  DT.404532  DT.103938  DT.442178  DT.92061044 

    Selected AceView cDNA sequences (see all 34):

    CB161594 AV660430 AY437532 NM_199352 N73833 AA010384 AV656281 AK127610 
    BG618159 BG567042 AA010320 N71631 AV659781 BX283020 H65471 AK091990 
    AX747296 N39517 T95616 H91000 H90890 AV651324 N45340 R93229 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A25    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
    SP1:                                                                              
    SP2:                    -     -                             -     -     -         
    SP3:                    -     -                                                   
    SP4:              -     -     -     -     -                       -     -         


    ECgene alternative splicing isoforms for SLC22A25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATACAAT
    SLC22A25 Expression
    About this image

    SLC22A25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.332119

    UniProtKB/Swiss-Prot: S22AP_HUMAN, Q6T423
    Tissue specificity: Expressed exclusively in liver in both embryo and adult

        Custom PCR Arrays for SLC22A25
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SLC22A25 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a301 solute carrier family 22, member 30 69.53(n)
    56.12(a)
      319800  NM_177002.3  NP_795976.1 


    ENSEMBL Gene Tree for SLC22A25 (if available)
    TreeFam Gene Tree for SLC22A25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A25 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  
    SLC22A132  SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A32  
    15 SIMAP similar genes for SLC22A25 using alignment to 5 protein entries:     S22AP_HUMAN (see all proteins):
    UST6    OAT7    SLC22A9    SLC22A24    SLC22A10    HMFN2567
    SLC22A11    SLC22A12    SLC22A6    SLC22A16    SLC22A20    SLC22A8
    SLC22A13    SLC22A7    SVOP

    Find genes that share paralogs with SLC22A25           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SLC22A25
    PGOHUM00000257835 PGOHUM00000257836 PGOHUM00000257891


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A25 (see all 1681)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460039281,2
    C--62930796(+) CCAACA/GCTTTT 1 -- ds50010--------
    rs1386377331,2
    --62930808(+) TTCCCC/TCGTGA 1 -- ds50010--------
    rs583015661,2
    C,F--62930863(+) CATCTG/TTGGGA 1 -- ds50012Minor allele frequency- T:0.13WA 120
    rs781213211,2
    C--62931014(+) GATCCC/TTGCAT 1 -- ds50012Minor allele frequency- T:0.09CSA WA 120
    rs1420433281,2
    --62931129(+) GGGCAA/GAGATG 1 -- ds50010--------
    rs773948721,2
    C,F--62931148(+) GATCTA/GGTGAG 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs79378561,2
    C,F,H--62931254(+) TGGGGG/AATGGT 1 -- ds500112Minor allele frequency- A:0.07NS EA NA CSA WA 1474
    rs1404603871,2
    C--62931298(+) GACCTA/C/TTAGCA 3 K E * stop-lost1EU 1323
    rs2006657871,2
    --62931354(+) CCACAA/TCCTGG 2 D V mis10--------
    rs1469985141,2
    C,F--62931398(+) GGAAGG/AAGGAG 2 /L syn11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for SLC22A25 (62931248 - 62997124 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC22A25:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744609CNV Deletion23290073
    nsv897627CNV Loss21882294
    esv33721CNV Loss17666407
    nsv897626CNV Loss21882294
    esv34011CNV Loss18971310

    Human Gene Mutation Database (HGMD): SLC22A25
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A25
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610792    OMIM disorders: --


    Find genes that share disorders with SLC22A25           About GenesLikeMe


    Export disorders for SLC22A25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A25 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SLC22A25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PubMed id 17714910)1, 3 Jacobsson J.A.... Fredriksson R. (Genomics 2007)
    2. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. (PubMed id 15054140)1, 2 Eraly S.A.... Nigam S.K. (Physiol. Genomics 2004)
    3. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. (PubMed id 18466105)1 ZaA^r Z.M....Kullak-Ublick G.A. (Pharmacogenomics 2008)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387601 HGNC: 32935 AceView: LOC387601 Ensembl:ENSG00000196600 euGenes: HUgn387601
    ECgene: SLC22A25 H-InvDB: SLC22A25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A25 gene:
    Search GeneIP for patents involving SLC22A25

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC22A25
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     antibodies-online antibodies for SLC22A25
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      Search antibodies-online for proteins for SLC22A25
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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