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Aliases for SLC22A25 Gene

Aliases for SLC22A25 Gene

  • Solute Carrier Family 22, Member 25 2 3
  • UST6 3 4 6
  • MGI:2442751, MGI:2385316, MGI:3042283, MGI:3645714, MGI:3605624, MGI:2442750 2 3
  • Organic Anion Transporter UST6 3 4
  • Putative UST1-Like Organic Anion Transporter 3
  • Solute Carrier Family 22 Member 25 3
  • HIMTP 3

External Ids for SLC22A25 Gene

Previous GeneCards Identifiers for SLC22A25 Gene

  • GC11M062688
  • GC11M062931
  • GC11M059260

Summaries for SLC22A25 Gene

GeneCards Summary for SLC22A25 Gene

SLC22A25 (Solute Carrier Family 22, Member 25) is a Protein Coding gene. An important paralog of this gene is SLC22A12.

Gene Wiki entry for SLC22A25 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A25 Gene

Genomics for SLC22A25 Gene

Regulatory Elements for SLC22A25 Gene

Genomic Location for SLC22A25 Gene

Start:
63,163,051 bp from pter
End:
63,237,943 bp from pter
Size:
74,893 bases
Orientation:
Minus strand

Genomic View for SLC22A25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A25 Gene

Proteins for SLC22A25 Gene

  • Protein details for SLC22A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6T423-S22AP_HUMAN
    Recommended name:
    Solute carrier family 22 member 25
    Protein Accession:
    Q6T423
    Secondary Accessions:
    • A4FU27

    Protein attributes for SLC22A25 Gene

    Size:
    547 amino acids
    Molecular mass:
    61008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A25 Gene

Proteomics data for SLC22A25 Gene at MOPED

Post-translational modifications for SLC22A25 Gene

  • Glycosylation at Asn56 and Asn102
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A25 Gene

No data available for DME Specific Peptides for SLC22A25 Gene

Domains for SLC22A25 Gene

Gene Families for SLC22A25 Gene

Protein Domains for SLC22A25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6T423

UniProtKB/Swiss-Prot:

S22AP_HUMAN :
  • Q6T423
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A25: view

Function for SLC22A25 Gene

Gene Ontology (GO) - Molecular Function for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC22A25: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC22A25 Gene

Localization for SLC22A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A25 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A25 Gene COMPARTMENTS Subcellular localization image for SLC22A25 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A25: view

Pathways for SLC22A25 Gene

SuperPathways for SLC22A25 Gene

No Data Available

Interacting Proteins for SLC22A25 Gene

Gene Ontology (GO) - Biological Process for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A25: view

No data available for Pathways by source for SLC22A25 Gene

Transcripts for SLC22A25 Gene

Unigene Clusters for SLC22A25 Gene

Solute carrier family 22, member 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1:
SP2: - - - - -
SP3: - -
SP4: - - - - - - -

Relevant External Links for SLC22A25 Gene

GeneLoc Exon Structure for
SLC22A25
ECgene alternative splicing isoforms for
SLC22A25

Expression for SLC22A25 Gene

mRNA expression in normal human tissues for SLC22A25 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A25 Gene

This gene is overexpressed in Liver (50.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC22A25 Gene

SOURCE GeneReport for Unigene cluster for SLC22A25 Gene Hs.332119

mRNA Expression by UniProt/SwissProt for SLC22A25 Gene

Q6T423-S22AP_HUMAN
Tissue specificity: Expressed exclusively in liver in both embryo and adult.
genes like me logo Genes that share expressions with SLC22A25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC22A25 Gene

Orthologs for SLC22A25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A25 35
  • 98.62 (n)
  • 97.19 (a)
SLC22A25 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc22a19 36
  • 55 (a)
ManyToMany
Slc22a26 36
  • 52 (a)
ManyToMany
Slc22a27 36
  • 55 (a)
ManyToMany
Slc22a28 36
  • 55 (a)
ManyToMany
Slc22a29 36
  • 55 (a)
ManyToMany
Slc22a30 35
  • 69.53 (n)
  • 56.12 (a)
Slc22a30 36
  • 56 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ust5r 35
  • 68.86 (n)
  • 54.41 (a)
Species with no ortholog for SLC22A25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC22A25 Gene

ENSEMBL:
Gene Tree for SLC22A25 (if available)
TreeFam:
Gene Tree for SLC22A25 (if available)

Paralogs for SLC22A25 Gene

Pseudogenes.org Pseudogenes for SLC22A25 Gene

genes like me logo Genes that share paralogs with SLC22A25: view

Variants for SLC22A25 Gene

Sequence variations from dbSNP and Humsavar for SLC22A25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1122524 -- 63,163,285(-) GAATT(G/T)TTTAA utr-variant-3-prime
rs1152250 -- 63,220,542(-) gtatg(C/T)ctgtt intron-variant
rs1193642 -- 63,216,402(-) tatag(C/T)agaag intron-variant
rs1193643 -- 63,215,964(-) atgca(A/G)ccata intron-variant
rs1193644 -- 63,215,877(-) aacac(A/G)aaacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A25 Gene

Variant ID Type Subtype PubMed ID
esv34011 CNV Loss 18971310
nsv897626 CNV Loss 21882294
esv2744609 CNV Deletion 23290073
esv33721 CNV Loss 17666407
nsv897627 CNV Loss 21882294

Relevant External Links for SLC22A25 Gene

HapMap Linkage Disequilibrium report
SLC22A25
Human Gene Mutation Database (HGMD)
SLC22A25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A25 Gene

Disorders for SLC22A25 Gene

No disorders were found for SLC22A25 Gene.

No data available for UniProtKB/Swiss-Prot for SLC22A25 Gene

Publications for SLC22A25 Gene

  1. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. (PMID: 15054140) Eraly S.A. … Nigam S.K. (Physiol. Genomics 2004) 3 4
  2. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 2 3
  3. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. (PMID: 18466105) ZaA^r Z.M. … Kullak-Ublick G.A. (Pharmacogenomics 2008) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for SLC22A25 Gene

Sources for SLC22A25 Gene

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