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Aliases for SLC22A25 Gene

Aliases for SLC22A25 Gene

  • Solute Carrier Family 22 Member 25 2 3 5
  • MGI:2442751, MGI:2385316, MGI:3042283, MGI:3645714, MGI:3605624, MGI:2442750 2 3
  • Solute Carrier Family 22, Member 25 2 3
  • Organic Anion Transporter UST6 3 4
  • UST6 3 4
  • Putative UST1-Like Organic Anion Transporter 3
  • HIMTP 3

External Ids for SLC22A25 Gene

Previous GeneCards Identifiers for SLC22A25 Gene

  • GC11M062688
  • GC11M062931
  • GC11M059260

Summaries for SLC22A25 Gene

GeneCards Summary for SLC22A25 Gene

SLC22A25 (Solute Carrier Family 22 Member 25) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A12.

Gene Wiki entry for SLC22A25 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A25 Gene

Genomics for SLC22A25 Gene

Regulatory Elements for SLC22A25 Gene

Enhancers for SLC22A25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC22A25 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A25 Gene

63,162,266 bp from pter
63,243,516 bp from pter
81,251 bases
Minus strand

Genomic View for SLC22A25 Gene

Genes around SLC22A25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A25 Gene

Proteins for SLC22A25 Gene

  • Protein details for SLC22A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 22 member 25
    Protein Accession:
    Secondary Accessions:
    • A4FU27

    Protein attributes for SLC22A25 Gene

    547 amino acids
    Molecular mass:
    61008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC22A25 Gene

Proteomics data for SLC22A25 Gene at MOPED

Post-translational modifications for SLC22A25 Gene

  • Glycosylation at Asn 56 and Asn 102
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A25 Gene

No data available for DME Specific Peptides for SLC22A25 Gene

Domains & Families for SLC22A25 Gene

Gene Families for SLC22A25 Gene


Protein Domains for SLC22A25 Gene


Suggested Antigen Peptide Sequences for SLC22A25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A25: view

Function for SLC22A25 Gene

genes like me logo Genes that share phenotypes with SLC22A25: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A25 Gene

Localization for SLC22A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A25 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC22A25 Gene COMPARTMENTS Subcellular localization image for SLC22A25 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for SLC22A25 Gene

Pathways & Interactions for SLC22A25 Gene

SuperPathways for SLC22A25 Gene

No Data Available

Interacting Proteins for SLC22A25 Gene

Gene Ontology (GO) - Biological Process for SLC22A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043252 sodium-independent organic anion transport IBA --
genes like me logo Genes that share ontologies with SLC22A25: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A25 Gene

Drugs & Compounds for SLC22A25 Gene

No Compound Related Data Available

Transcripts for SLC22A25 Gene

Unigene Clusters for SLC22A25 Gene

Solute carrier family 22, member 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP2: - - - - -
SP3: - -
SP4: - - - - - - -

Relevant External Links for SLC22A25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC22A25 Gene

mRNA expression in normal human tissues for SLC22A25 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A25 Gene

This gene is overexpressed in Liver (x50.1).

Protein differential expression in normal tissues from HIPED for SLC22A25 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A25 Gene

SOURCE GeneReport for Unigene cluster for SLC22A25 Gene Hs.332119

mRNA Expression by UniProt/SwissProt for SLC22A25 Gene

Tissue specificity: Expressed exclusively in liver in both embryo and adult.
genes like me logo Genes that share expression patterns with SLC22A25: view

Protein tissue co-expression partners for SLC22A25 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC22A25 Gene

Orthologs for SLC22A25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A25 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Slc22a30 35
  • 69.53 (n)
  • 56.12 (a)
Slc22a30 16
Slc22a19 36
  • 55 (a)
Slc22a26 36
  • 52 (a)
Slc22a27 36
  • 55 (a)
Slc22a28 36
  • 55 (a)
Slc22a29 36
  • 55 (a)
Slc22a30 36
  • 56 (a)
(Pan troglodytes)
Mammalia SLC22A25 35
  • 98.62 (n)
  • 97.19 (a)
SLC22A25 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Ust5r 35
  • 68.86 (n)
  • 54.41 (a)
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 69 (a)
(Canis familiaris)
Mammalia -- 36
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
-- 36
  • 36 (a)
Species with no ortholog for SLC22A25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC22A25 Gene

Gene Tree for SLC22A25 (if available)
Gene Tree for SLC22A25 (if available)

Paralogs for SLC22A25 Gene Pseudogenes for SLC22A25 Gene

genes like me logo Genes that share paralogs with SLC22A25: view

Variants for SLC22A25 Gene

Sequence variations from dbSNP and Humsavar for SLC22A25 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11231409 - 63,217,396(+) CAGGC(C/T)TCCCA reference, missense
rs11231397 - 63,183,749(+) CTTTT(C/G)TAAGT reference, missense
rs35722529 - 63,229,388(+) GCGAC(A/G)ACACT reference, missense
rs17157907 - 63,164,577(+) TAATG(C/G/T)CAAGA reference, missense
rs6591771 - 63,164,012(+) CATCA(C/T)GAGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC22A25 Gene

Variant ID Type Subtype PubMed ID
esv34011 CNV Loss 18971310
nsv897626 CNV Loss 21882294
esv2744609 CNV Deletion 23290073
esv33721 CNV Loss 17666407
nsv897627 CNV Loss 21882294

Variation tolerance for SLC22A25 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.76; 93.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A25 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A25 Gene

Disorders for SLC22A25 Gene

Relevant External Links for SLC22A25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC22A25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A25 Gene

Publications for SLC22A25 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 2 3 67
  2. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. (PMID: 18466105) ZaA^r Z.M. … Kullak-Ublick G.A. (Pharmacogenomics 2008) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. (PMID: 15054140) Eraly S.A. … Nigam S.K. (Physiol. Genomics 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC22A25 Gene

Sources for SLC22A25 Gene