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SLC22A24 Gene

protein-coding   GIFtS: 44
GCID: GC11M062847

Solute Carrier Family 22, Member 24

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22, Member 241 2
NET462
Solute Carrier Family 22 Member 242

External Ids:    HGNC: 285421   Entrez Gene: 2832382   Ensembl: ENSG000001976587   OMIM: 6116985   UniProtKB: Q8N4F43   

Export aliases for SLC22A24 gene to outside databases

Previous GC identifers: GC11M062644 GC11M062603 GC11M059176


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A24 Gene:
SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and
antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 (PubMed 17714910)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for SLC22A24 Gene:
SLC22A24 (solute carrier family 22, member 24) is a protein-coding gene. An important paralog of this gene is SLC22A11.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A24 gene promoter:
         AP-2rep   AREB6   IRF-2   IRF-1   LCR-F1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLC22A24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

SLC22A24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A24 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062847:  view genomic region     (about GC identifiers)

Start:
62,847,412 bp from pter      End:
62,911,693 bp from pter
Size:
64,282 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S22AO_HUMAN, Q8N4F4 (See protein sequence)
Recommended Name: Solute carrier family 22 member 24  
Size: 322 amino acids; 35933 Da

Explore the universe of human proteins at neXtProt for SLC22A24: NX_Q8N4F4

Explore proteomics data for SLC22A24 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC22A24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129978.2  NP_775857.2  

    ENSEMBL proteins: 
     ENSP00000396586   ENSP00000321549  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SLC22A24
    Orphan or poorly characterized SLC22 family members

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8N4F4

    ProtoNet protein and cluster: Q8N4F4

    UniProtKB/Swiss-Prot: S22AO_HUMAN, Q8N4F4
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC22A24           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC22A24

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22AO_HUMAN, Q8N4F4: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC22A24           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A24
    Interactions:

        Search GeneGlobe Interaction Network for SLC22A24

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for SLC22A24 (Q8N4F42, 3 ENSP000003965864) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443, ENSP000003810314I2D: score=1 STRING: ENSP00000381031
    --Q9BWA23, 2MINT-66087 I2D: score=1 
    --Q9BWA23, 2MINT-66087 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0055085transmembrane transport IEA--

    Find genes that share ontologies with SLC22A24           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A24 (S22AO)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A24 gene (2 alternative transcripts): 
    NM_001136506.2  NM_173586.2  

    Unigene Cluster for SLC22A24:

    Solute carrier family 22, member 24
    Hs.375139  [show with all ESTs]
    Unigene Representative Sequence: NM_001136506
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417740(uc021qkp.1) ENST00000326192(uc010rmn.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLC22A24

    Additional mRNA sequence: BC034394.1 

    1 DOTS entry:

    DT.95206215 

    5 AceView cDNA sequences:

    BC034394 BI763962 NM_173586 BV172845 AI796281 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATTATCAT
    SLC22A24 Expression
    About this image

    SLC22A24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375139
        Custom PCR Arrays for SLC22A24
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC22A24 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a191 , 5 solute carrier family 22 (organic anion transporter), more1, 5 67.15(n)1
    53.01(a)1
      19 (5.34 cM)5
    2071511  NM_144785.21  NP_659034.11 
     76730615 
    soybean
    (Glycine max)
    eudicotyledons 467656072   -- 91.67(n)  


    ENSEMBL Gene Tree for SLC22A24 (if available)
    TreeFam Gene Tree for SLC22A24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A24 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A42  SLC22A22  SLC22A102  SLC22A132  
    SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A32  SLC22A252  
    15 SIMAP similar genes for SLC22A24 using alignment to 2 protein entries:     S22AO_HUMAN (see all proteins):
    UST6    SLC22A25    OAT7    SLC22A9    SLC22A10    HMFN2567
    SLC22A11    SLC22A12    SLC22A6    SLC22A20    SLC22A8    SLC22A7
    SLC22A13    SLC22A3    SLC22A2

    Find genes that share paralogs with SLC22A24           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A24 (see all 1635)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383019401,2
    --62846947(+) CATAGG/TTTACT 1 -- ds50010--------
    rs569644321,2
    C--62846985(+) AGACT-/CTTTCTG 1 -- ds50010--------
    rs1176399941,2
    C,F--62847023(+) CATTAC/TGGTGT 1 -- ds50011Minor allele frequency- T:0.04NA 120
    rs757318501,2
    C,F--62847024(+) ATTACG/AGTGTG 1 -- ds50013Minor allele frequency- A:0.13WA CSA 122
    rs1830402011,2
    --62847111(+) TTTACC/TGTATA 1 -- ds50010--------
    rs1418144801,2
    C--62847112(+) TTACCA/GTATAT 1 -- ds50010--------
    rs791560181,2
    C,F--62847132(+) TGATCG/ATCACT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs171577161,2
    C,F,H--62847161(+) TGAATC/AATCTT 1 -- ds500116Minor allele frequency- A:0.10NA NS EA WA CSA 1355
    rs1507048481,2
    --62847254(+) TAAACG/TTATAA 1 -- ds50010--------
    rs729182181,2
    C,F--62847335(+) GGCTAG/CTTTTG 1 -- ds50011Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for SLC22A24 (62847412 - 62911693 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SLC22A24:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744607CNV Deletion23290073
    esv1159693CNV Deletion17803354
    esv1629652CNV Insertion17803354
    nsv468587CNV Loss19166990
    esv34011CNV Loss18971310
    nsv517447CNV Loss19592680
    nsv897626CNV Loss21882294
    nsv897625CNV Loss21882294
    nsv522971CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611698    OMIM disorders: --


    Find genes that share disorders with SLC22A24           About GenesLikeMe

    Genetic Association Database (GAD): SLC22A24

    Export disorders for SLC22A24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A24 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SLC22A24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PubMed id 17714910)1, 2, 3 Jacobsson J.A.... Fredriksson R. (Genomics 2007)
    2. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283238 HGNC: 28542 AceView: MGC34821 Ensembl:ENSG00000197658 euGenes: HUgn283238
    ECgene: SLC22A24 H-InvDB: SLC22A24

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A24 gene:
    Search GeneIP for patents involving SLC22A24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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