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Aliases for SLC22A23 Gene

Aliases for SLC22A23 Gene

  • Solute Carrier Family 22, Member 23 2 3
  • C6orf85 3 4 6
  • Chromosome 6 Open Reading Frame 85 2
  • Solute Carrier Family 22 Member 23 3
  • Ion Transporter Protein 3

External Ids for SLC22A23 Gene

Previous HGNC Symbols for SLC22A23 Gene

  • C6orf85

Previous GeneCards Identifiers for SLC22A23 Gene

  • GC06M003216
  • GC06M003147

Summaries for SLC22A23 Gene

Entrez Gene Summary for SLC22A23 Gene

  • SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC22A23 Gene

SLC22A23 (Solute Carrier Family 22, Member 23) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A17.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A23 Gene

Genomics for SLC22A23 Gene

Regulatory Elements for SLC22A23 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC22A23 Gene

Start:
3,268,962 bp from pter
End:
3,457,022 bp from pter
Size:
188,061 bases
Orientation:
Minus strand

Genomic View for SLC22A23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A23 Gene

Proteins for SLC22A23 Gene

  • Protein details for SLC22A23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A5C7-S22AN_HUMAN
    Recommended name:
    Solute carrier family 22 member 23
    Protein Accession:
    A1A5C7
    Secondary Accessions:
    • A1A5C8
    • Q5T8B8
    • Q6ZMH3
    • Q8IW73

    Protein attributes for SLC22A23 Gene

    Size:
    686 amino acids
    Molecular mass:
    73748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18753.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12303.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A23 Gene

Proteomics data for SLC22A23 Gene at MOPED

Post-translational modifications for SLC22A23 Gene

  • Glycosylation at Asn24, Thr143, and Asn279
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A23 Gene

Domains for SLC22A23 Gene

Gene Families for SLC22A23 Gene

Protein Domains for SLC22A23 Gene

Suggested Antigen Peptide Sequences for SLC22A23 Gene

Graphical View of Domain Structure for InterPro Entry

A1A5C7

UniProtKB/Swiss-Prot:

S22AN_HUMAN :
  • A1A5C7
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A23: view

Function for SLC22A23 Gene

Gene Ontology (GO) - Molecular Function for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A23: view

Phenotypes for SLC22A23 Gene

genes like me logo Genes that share phenotypes with SLC22A23: view

Animal Model Products

CRISPR Products

miRNA for SLC22A23 Gene

miRTarBase miRNAs that target SLC22A23

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A23

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC22A23 Gene

Localization for SLC22A23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A23 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A23 Gene COMPARTMENTS Subcellular localization image for SLC22A23 gene
Compartment Confidence
plasma membrane 3
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A23: view

Pathways for SLC22A23 Gene

SuperPathways for SLC22A23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A23: view

No data available for Pathways by source for SLC22A23 Gene

Transcripts for SLC22A23 Gene

Unigene Clusters for SLC22A23 Gene

Solute carrier family 22, member 23:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A23

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC22A23

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A23 Gene

No ASD Table

Relevant External Links for SLC22A23 Gene

GeneLoc Exon Structure for
SLC22A23
ECgene alternative splicing isoforms for
SLC22A23

Expression for SLC22A23 Gene

mRNA expression in normal human tissues for SLC22A23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC22A23 Gene

SOURCE GeneReport for Unigene cluster for SLC22A23 Gene Hs.713588

genes like me logo Genes that share expressions with SLC22A23: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC22A23 Gene

Orthologs for SLC22A23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A23 35
  • 98.3 (n)
  • 98.4 (a)
SLC22A23 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A23 35
  • 87.41 (n)
  • 90.62 (a)
SLC22A23 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A23 35
  • 91.69 (n)
  • 96.54 (a)
SLC22A23 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a23 35
  • 89.18 (n)
  • 92.51 (a)
Slc22a23 16
Slc22a23 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A23 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A23 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a23 35
  • 89.23 (n)
  • 92.8 (a)
chicken
(Gallus gallus)
Aves SLC22A23 35
  • 79.16 (n)
  • 81.89 (a)
SLC22A23 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a23 35
  • 68.41 (n)
  • 73.38 (a)
zebrafish
(Danio rerio)
Actinopterygii SLC22A23 (1 of 3) 36
  • 38 (a)
OneToMany
SLC22A23 (2 of 3) 36
  • 60 (a)
OneToMany
SLC22A23 (3 of 3) 36
  • 47 (a)
OneToMany
Species with no ortholog for SLC22A23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A23 Gene

ENSEMBL:
Gene Tree for SLC22A23 (if available)
TreeFam:
Gene Tree for SLC22A23 (if available)

Paralogs for SLC22A23 Gene

Paralogs for SLC22A23 Gene

Selected SIMAP similar genes for SLC22A23 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC22A23: view

Variants for SLC22A23 Gene

Sequence variations from dbSNP and Humsavar for SLC22A23 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4176 -- 3,269,660(+) AGGAC(-/AG)AGGGA utr-variant-3-prime, nc-transcript-variant
rs8790 -- 3,269,584(-) ATAGC(A/C)CAAGC utr-variant-3-prime, nc-transcript-variant
rs717123 -- 3,391,345(+) GTCAT(C/G)AGGCT intron-variant
rs729131 -- 3,444,736(+) ACTTA(A/G)ACACA intron-variant
rs730487 -- 3,349,796(+) ATATG(A/G)AGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A23 Gene

Variant ID Type Subtype PubMed ID
dgv6430n71 CNV Loss 21882294
nsv883410 CNV Loss 21882294
esv24289 CNV Loss 19812545
esv2731491 CNV Deletion 23290073
esv2731492 CNV Deletion 23290073
esv2731493 CNV Deletion 23290073
esv2167684 CNV Deletion 18987734
esv2731494 CNV Deletion 23290073
esv2669587 CNV Deletion 23128226
esv2461941 CNV Insertion 19546169
esv2678916 CNV Deletion 23128226

Relevant External Links for SLC22A23 Gene

HapMap Linkage Disequilibrium report
SLC22A23
Human Gene Mutation Database (HGMD)
SLC22A23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A23 Gene

Disorders for SLC22A23 Gene

(1) University of Copenhagen DISEASES for SLC22A23 Gene

Relevant External Links for SLC22A23

Genetic Association Database (GAD)
SLC22A23
Human Genome Epidemiology (HuGE) Navigator
SLC22A23
genes like me logo Genes that share disorders with SLC22A23: view

No data available for UniProtKB/Swiss-Prot for SLC22A23 Gene

Publications for SLC22A23 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 2 3 4
  2. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. (PMID: 19068216) Anderson C.A. … Parkes M. (Gastroenterology 2009) 3 48
  3. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PMID: 19174780) Weersma R.K. … Vermeire S. (Am. J. Gastroenterol. 2009) 3 48
  4. Genetic risk profiling and prediction of disease course in Crohn's disease patients. (PMID: 19422935) Henckaerts L. … Vermeire S. (Clin. Gastroenterol. Hepatol. 2009) 3 48
  5. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PMID: 19760754) TAPrkvist L. … Pettersson S. (Inflamm. Bowel Dis. 2010) 3 48

Products for SLC22A23 Gene

  • antibodies-online peptides for SLC22A23
  • antibodies-online antibodies for SLC22A23
  • antibodies-online kits for SLC22A23

Sources for SLC22A23 Gene

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