Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC22A23 Gene

protein-coding   GIFtS: 47
GCID: GC06M003269

Solute Carrier Family 22, Member 23

(Previous name: chromosome 6 open reading frame 85)
(Previous symbol: C6orf85)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 22, Member 231 2
C6orf851 2 3 5
Chromosome 6 Open Reading Frame 851
Ion Transporter Protein2
Solute Carrier Family 22 Member 232

External Ids:    HGNC: 211061   Entrez Gene: 630272   Ensembl: ENSG000001372667   OMIM: 6116975   UniProtKB: A1A5C73   

Export aliases for SLC22A23 gene to outside databases

Previous GC identifers: GC06M003216 GC06M003147


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC22A23 Gene:
SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and
antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 (PubMed 17714910)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for SLC22A23 Gene: 
SLC22A23 (solute carrier family 22, member 23) is a protein-coding gene. Diseases associated with SLC22A23 include wolf-hirschhorn syndrome, and spondylitis. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A17.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC22A23 gene promoter:
         Sox5   SREBP-1c   Egr-4   Arnt   SREBP-1b   PPAR-gamma1   SREBP-1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A23 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC22A23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

SLC22A23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A23 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M003269:  view genomic region     (about GC identifiers)

Start:
3,269,196 bp from pter      End:
3,457,256 bp from pter
Size:
188,061 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S22AN_HUMAN, A1A5C7 (See protein sequence)
Recommended Name: Solute carrier family 22 member 23  
Size: 686 amino acids; 73748 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAD18753.1; Type=Erroneous initiation; Sequence=CAI12303.1; Type=Erroneous gene model
prediction; Sequence=CAI40959.1; Type=Erroneous gene model prediction;
Secondary accessions: A1A5C8 Q5T8B8 Q6ZMH3 Q8IW73
Alternative splicing: 4 isoforms:  A1A5C7-1   A1A5C7-2   A1A5C7-3   A1A5C7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC22A23: NX_A1A5C7

Explore proteomics data for SLC22A23 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A1A5C7

  • SLC22A23 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC22A23 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_056297.1  NP_068764.3  

    ENSEMBL proteins: 
     ENSP00000410245   ENSP00000385028   ENSP00000417737   ENSP00000369657   ENSP00000419463  
     ENSP00000418134   ENSP00000418985   ENSP00000369653  

    Human Recombinant Protein Products for SLC22A23: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC22A23
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC22A23
    GenScript Custom Purified and Recombinant Proteins Services for SLC22A23
    Novus Biologicals SLC22A23 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC22A23 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SLC22A23 for ontologies           About GeneDecksing



    SLC22A23 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC22A23
    GenScript Custom Superior Antibodies Services for SLC22A23
    Novus Biologicals SLC22A23 Antibody
    Abcam antibodies for SLC22A23
    Cloud-Clone Corp. Antibodies for SLC22A23 
    Search ThermoFisher Antibodies for SLC22A23
    LSBio Antibodies in human, mouse, rat for SLC22A23 

    Assay Products for SLC22A23: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC22A23
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC22A23
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC22A23 
    Cloud-Clone Corp. CLIAs for SLC22A23


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SLC22A23 
    Orphan or poorly characterized SLC22 family members

    4 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry A1A5C7

    ProtoNet protein and cluster: A1A5C7

    UniProtKB/Swiss-Prot: S22AN_HUMAN, A1A5C7
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    SLC22A23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity IEA--
         
    SLC22A23 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC22A23:
     Increased viability after born 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC22A23 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC22A23

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC22A23 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC22A23 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC22A23
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC22A23 (see all 109):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-106a hsa-miR-128 hsa-miR-938
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC22A23
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC22A23

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC22A23
    Sirion Biotech Customized adenovirus for overexpression of SLC22A23

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC22A23 (see all 12)
    OriGene ORF clones in mouse, rat for SLC22A23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC22A23 (NM_021945)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A23
    Sirion Biotech Customized lentivirus for stable overexpression of SLC22A23 
                         Customized lentivirus expression plasmids for stable overexpression of SLC22A23 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC22A23
    Search LifeMap BioReagents cell lines for SLC22A23
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A23


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC22A23

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC22A23 (ENSP000003850284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0055085transmembrane transport ----

    SLC22A23 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC22A23 (S22AN)

    Search CenterWatch for drugs/clinical trials and news about SLC22A23 / S22AN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC22A23 gene (2 alternative transcripts): 
    NM_015482.1  NM_021945.5  

    Unigene Cluster for SLC22A23:

    Solute carrier family 22, member 23
    Hs.713588  [show with all ESTs]
    Unigene Representative Sequence: NM_015482
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436008(uc003mvn.3 uc003mvo.3 uc003mvm.3) ENST00000406686(uc010jnn.3)
    ENST00000497691(uc003mvp.1) ENST00000380302 ENST00000490273 ENST00000482874
    ENST00000485307 ENST00000467177 ENST00000467144 ENST00000496753 ENST00000433689
    ENST00000380298(uc010jno.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC22A23
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC22A23 (see all 109):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-106a hsa-miR-128 hsa-miR-938
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC22A23
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC22A23
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC22A23 (see all 12)
    OriGene ORF clones in mouse, rat for SLC22A23
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC22A23 (NM_021945)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A23
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A23
    Sirion Biotech Customized lentivirus for stable overexpression of SLC22A23 
                         Customized lentivirus expression plasmids for stable overexpression of SLC22A23 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A23
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC22A23
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A23

    Additional mRNA sequence: 

    AJ420525.1 AK000691.1 AK025033.1 AK025827.1 AK172770.1 AK225936.1 AK308282.1 AK308943.1 
    AL110245.1 AL512737.1 BC022217.1 BC038748.1 BC040876.1 BC090851.1 BC128580.1 BC128581.1 

    12 DOTS entries:

    DT.100787177  DT.97781715  DT.453023  DT.100017740  DT.95273920  DT.121379727  DT.121379756  DT.121380013 
    DT.40109362  DT.95246442  DT.121379781  DT.95273924 

    24/198 AceView cDNA sequences (see all 198):

    AI867904 Z41786 CD722175 BM993128 AI446649 BM980165 AI888634 BU739429 
    CR610126 W80733 AI632136 CB161497 AW291160 NM_021945 AI362326 AW136148 
    Z45225 AL110245 AK172770 AA339438 AI989962 F05032 BC040876 BF062357 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC22A23 expression in normal human tissues (normalized intensities)      SLC22A23 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCGCATC
    SLC22A23 Expression
    About this image


    SLC22A23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Epithelium
             Human Choroid Plexus Epithelial Cells (HCPEpiC)   
     
     Choroid Plexus (Uncategorized)
             Human Choroid Plexus Epithelial Cells (HCPEpiC)   
     
     Brain (Nervous System)
             Human Hippocampal Astrocytes   

    See SLC22A23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC22A23

    SOURCE GeneReport for Unigene cluster: Hs.713588
        SABiosciences Custom PCR Arrays for SLC22A23
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A23
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC22A23
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A23
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A23
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC22A23 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a231 , 5 solute carrier family 22, member 231, 5 89.18(n)1
    92.51(a)1
      13 (14.05 cM)5
    731021  NM_001033167.31  NP_001028339.11 
     341791585 
    chicken
    (Gallus gallus)
    Aves SLC22A231 solute carrier family 22, member 23 79.32(n)
    82.36(a)
      420881  XM_418968.3  XP_418968.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC22A236
    --
    Uncharacterized protein
    65(a)
    63(a)
    1 ↔ many
    1 ↔ many
    GL343247.1(1132804-1250195)
    GL344288.1(16254-43885)
    zebrafish
    (Danio rerio)
    Actinopterygii SLC22A23 (2 of 2)6
    --
    (see all 3)
    --
    61(a)
    47(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    20(53322080-53328383)
    20(53373636-53389790)


    ENSEMBL Gene Tree for SLC22A23 (if available)
    TreeFam Gene Tree for SLC22A23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC22A23 gene
    SLC22A172  SLC22A312  
    4 SIMAP similar genes for SLC22A23 using alignment to 6 protein entries:     S22AN_HUMAN (see all proteins):
    DKFZp434F011    SLC22A10    SLC22A17    SLC22A31

    SLC22A23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4329 SNPs in SLC22A23 are shown (see all 4329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491328881,2
    C--3268898(+) GTGCA-/GGGCAA 2 -- int10--------
    rs1473651991,2
    --3268957(+) AACCCG/TTTTTG 2 -- int10--------
    rs1394096091,2
    --3269021(+) GTGACC/GCTGGC 2 -- int10--------
    rs1819610721,2
    --3269096(+) TTCCCA/GTGCTA 2 -- int10--------
    rs65969621,2
    C,F,A,H--3269147(+) TGAGTA/GGACAC 2 -- int111Minor allele frequency- G:0.19NA WA CSA EA 374
    rs1862963811,2
    --3269247(+) TTTTCA/GTTAAA 2 -- ut310--------
    rs1998324431,2
    C--3269409(+) TGATGC/GCCCCC 2 -- ut310--------
    rs1898952661,2
    --3269512(+) CAGAGA/TGAGAG 2 -- ut310--------
    rs755097751,2
    C--3269835(+) GCACCG/ATCAGA 2 -- ut311Minor allele frequency- A:0.01NA 120
    rs3776698801,2
    C--3269895(+) GGACA-/AGGGGAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC22A23 (3269196 - 3457256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for SLC22A23 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669587CNV Deletion23128226
    esv2731492CNV Deletion23290073
    esv2678916CNV Deletion23128226
    esv2731493CNV Deletion23290073
    esv2731494CNV Deletion23290073
    esv2731491CNV Deletion23290073
    esv2167684CNV Deletion18987734
    esv2461941CNV Insertion19546169
    nsv883410CNV Loss21882294
    dgv6430n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A23
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611697    OMIM disorders: --

    5 diseases for SLC22A23:    About MalaCards
    wolf-hirschhorn syndrome    spondylitis    ankylosing spondylitis    crohn's disease
    ulcerative colitis

    1 disease from the University of Copenhagen DISEASES database for SLC22A23:
    Wolf-Hirschhorn syndrome

    SLC22A23 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC22A23
    Human Genome Epidemiology (HuGE) Navigator: SLC22A23 (9 documents)

    Export disorders for SLC22A23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC22A23 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SLC22A23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PubMed id 17714910)1, 2, 3 Jacobsson J.A.... Fredriksson R. (2007)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (2010)
    4. Genome-wide association study of antipsychotic-induce d QTc interval prolongation. (PubMed id 20921969)1, 4 Aberg K....van den Oord E.J. (2010)
    5. Analysis of 39 Crohn's disease risk loci in Swedish i nflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (2010)
    6. Molecular reclassification of Crohn's disease by clus ter analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (2010)
    7. Genetic Risk Profiling And Prediction Of Disease Course In Crohn'S Disease Patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (2009)
    8. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1, 4 Weersma R.K....Vermeire S. (2009)
    9. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. (PubMed id 19068216)1, 4 Anderson C.A....Parkes M. (2009)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63027 HGNC: 21106 AceView: C6orf85 Ensembl:ENSG00000137266 euGenes: HUgn63027
    ECgene: SLC22A23 H-InvDB: SLC22A23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC22A23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC22A23 gene:
    Search GeneIP for patents involving SLC22A23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC22A23  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SLC22A23  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC22A23  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A23   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC22A23   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC22A23   OriGene Custom Protein Services for SLC22A23  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC22A23
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC22A23
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A23
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC22A23
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A23
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A23
     GenScript Custom Purified and Recombinant Proteins Services for SLC22A23 GenScript cDNA clones with any tag delivered in your preferred vector for SLC22A23
     GenScript Custom Assay Services for SLC22A23 GenScript Custom Superior Antibodies Services for SLC22A23
     GenScript Custom overexpressing Cell Line Services for SLC22A23 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC22A23 promoter
     Search Chromatin IP Primers for SLC22A23
     RT2 qPCR Primer Assay in human, mouse, rat SLC22A23
     Search GNC Networks for SLC22A23
     SABiosciences Custom PCR Arrays for SLC22A23
     Search Tocris compounds for SLC22A23 (S22AN)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC22A23 antibodies
     SLC22A23 lysates
     Antibodies for SLC22A23
     See all of Abcam's Antibodies, Kits and Proteins for SLC22A23
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLC22A23
     Antibodies for SLC22A23
     ELISAs for SLC22A23
     CLIAs for SLC22A23
     Search LifeMap BioReagents cell lines for SLC22A23
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A23
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SLC22A23
     SwitchGear Promoter luciferase reporter plasmids for SLC22A23
     Search ThermoFisher Antibodies for SLC22A23
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A23
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC22A23
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC22A23
    Customized:
     lentivirus for stable overexpression of SLC22A23
     lentivirus expression plasmids for stable overexpression of SLC22A23
     adenovirus for overexpression of SLC22A23
     LSBio Antibodies in human, mouse, rat for SLC22A23
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC22A23 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4