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Aliases for SLC22A23 Gene

Aliases for SLC22A23 Gene

  • Solute Carrier Family 22 Member 23 2 3 5
  • Solute Carrier Family 22, Member 23 2 3
  • C6orf85 3 4
  • Chromosome 6 Open Reading Frame 85 2
  • Ion Transporter Protein 3

External Ids for SLC22A23 Gene

Previous HGNC Symbols for SLC22A23 Gene

  • C6orf85

Previous GeneCards Identifiers for SLC22A23 Gene

  • GC06M003216
  • GC06M003147

Summaries for SLC22A23 Gene

Entrez Gene Summary for SLC22A23 Gene

  • SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC22A23 Gene

SLC22A23 (Solute Carrier Family 22 Member 23) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A17.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A23 Gene

Genomics for SLC22A23 Gene

Regulatory Elements for SLC22A23 Gene

Promoters for SLC22A23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC22A23 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A23 Gene

Chromosome:
6
Start:
3,268,962 bp from pter
End:
3,457,022 bp from pter
Size:
188,061 bases
Orientation:
Minus strand

Genomic View for SLC22A23 Gene

Genes around SLC22A23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A23 Gene

Proteins for SLC22A23 Gene

  • Protein details for SLC22A23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A5C7-S22AN_HUMAN
    Recommended name:
    Solute carrier family 22 member 23
    Protein Accession:
    A1A5C7
    Secondary Accessions:
    • A1A5C8
    • Q5T8B8
    • Q6ZMH3
    • Q8IW73

    Protein attributes for SLC22A23 Gene

    Size:
    686 amino acids
    Molecular mass:
    73748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18753.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12303.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A23 Gene

Proteomics data for SLC22A23 Gene at MOPED

Post-translational modifications for SLC22A23 Gene

  • Glycosylation at Asn 24, Thr 143, and Asn 279
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A23 Gene

Domains & Families for SLC22A23 Gene

Gene Families for SLC22A23 Gene

Protein Domains for SLC22A23 Gene

Suggested Antigen Peptide Sequences for SLC22A23 Gene

Graphical View of Domain Structure for InterPro Entry

A1A5C7

UniProtKB/Swiss-Prot:

S22AN_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A23: view

Function for SLC22A23 Gene

genes like me logo Genes that share phenotypes with SLC22A23: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A23 Gene

Localization for SLC22A23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A23 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A23 Gene COMPARTMENTS Subcellular localization image for SLC22A23 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for SLC22A23 Gene

Pathways & Interactions for SLC22A23 Gene

SuperPathways for SLC22A23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC22A23 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC22A23 Gene

Drugs & Compounds for SLC22A23 Gene

No Compound Related Data Available

Transcripts for SLC22A23 Gene

Unigene Clusters for SLC22A23 Gene

Solute carrier family 22, member 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A23 Gene

No ASD Table

Relevant External Links for SLC22A23 Gene

GeneLoc Exon Structure for
SLC22A23
ECgene alternative splicing isoforms for
SLC22A23

Expression for SLC22A23 Gene

mRNA expression in normal human tissues for SLC22A23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC22A23 Gene

This gene is overexpressed in Fetal Brain (49.3) and Frontal cortex (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A23 Gene



SOURCE GeneReport for Unigene cluster for SLC22A23 Gene Hs.713588

genes like me logo Genes that share expression patterns with SLC22A23: view

Protein tissue co-expression partners for SLC22A23 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC22A23 Gene

Orthologs for SLC22A23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A23 35
  • 98.3 (n)
  • 98.4 (a)
SLC22A23 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A23 36
  • 89 (a)
OneToOne
SLC22A23 35
  • 87.41 (n)
  • 90.62 (a)
dog
(Canis familiaris)
Mammalia SLC22A23 35
  • 91.69 (n)
  • 96.54 (a)
SLC22A23 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a23 35
  • 89.18 (n)
  • 92.51 (a)
Slc22a23 16
Slc22a23 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A23 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A23 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a23 35
  • 89.23 (n)
  • 92.8 (a)
chicken
(Gallus gallus)
Aves SLC22A23 35
  • 79.16 (n)
  • 81.89 (a)
SLC22A23 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a23 35
  • 68.41 (n)
  • 73.38 (a)
zebrafish
(Danio rerio)
Actinopterygii SLC22A23 (1 of 3) 36
  • 38 (a)
OneToMany
SLC22A23 (2 of 3) 36
  • 60 (a)
OneToMany
SLC22A23 (3 of 3) 36
  • 47 (a)
OneToMany
Species with no ortholog for SLC22A23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A23 Gene

ENSEMBL:
Gene Tree for SLC22A23 (if available)
TreeFam:
Gene Tree for SLC22A23 (if available)

Paralogs for SLC22A23 Gene

Paralogs for SLC22A23 Gene

(4) SIMAP similar genes for SLC22A23 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC22A23: view

Variants for SLC22A23 Gene

Sequence variations from dbSNP and Humsavar for SLC22A23 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs729131 -- 3,444,736(+) ACTTA(A/G)ACACA intron-variant
rs965650 -- 3,452,952(+) ACAAC(A/G)TTGGA intron-variant
rs928027 -- 3,454,812(+) TCCAT(G/T)AGCTA intron-variant
rs928028 -- 3,431,460(+) AACCA(C/T)CTATG intron-variant
rs1079284 -- 3,372,311(-) TGTTA(C/T)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A23 Gene

Variant ID Type Subtype PubMed ID
dgv6430n71 CNV Loss 21882294
nsv883410 CNV Loss 21882294
esv24289 CNV Loss 19812545
esv2731491 CNV Deletion 23290073
esv2731492 CNV Deletion 23290073
esv2731493 CNV Deletion 23290073
esv2167684 CNV Deletion 18987734
esv2731494 CNV Deletion 23290073
esv2669587 CNV Deletion 23128226
esv2461941 CNV Insertion 19546169
esv2678916 CNV Deletion 23128226

Variation tolerance for SLC22A23 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A23 Gene

HapMap Linkage Disequilibrium report
SLC22A23
Human Gene Mutation Database (HGMD)
SLC22A23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A23 Gene

Disorders for SLC22A23 Gene

Relevant External Links for SLC22A23

Genetic Association Database (GAD)
SLC22A23
Human Genome Epidemiology (HuGE) Navigator
SLC22A23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A23

No disorders were found for SLC22A23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A23 Gene

Publications for SLC22A23 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Single-nucleotide polymorphisms in SLC22A23 are associated with ulcerative colitis in a Canadian white cohort. (PMID: 24740203) Serrano LeA^n A. … Eck P. (Am. J. Clin. Nutr. 2014) 3
  5. Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. (PMID: 24204828) Zheng J.S. … Lai C.Q. (PLoS ONE 2013) 3

Products for SLC22A23 Gene

Sources for SLC22A23 Gene

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