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Aliases for SLC22A23 Gene

Aliases for SLC22A23 Gene

  • Solute Carrier Family 22 Member 23 2 3 5
  • C6orf85 3 4
  • Solute Carrier Family 22, Member 23 2
  • Chromosome 6 Open Reading Frame 85 2
  • Ion Transporter Protein 3

External Ids for SLC22A23 Gene

Previous HGNC Symbols for SLC22A23 Gene

  • C6orf85

Previous GeneCards Identifiers for SLC22A23 Gene

  • GC06M003216
  • GC06M003147

Summaries for SLC22A23 Gene

Entrez Gene Summary for SLC22A23 Gene

  • SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC22A23 Gene

SLC22A23 (Solute Carrier Family 22 Member 23) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A17.

Additional gene information for SLC22A23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A23 Gene

Genomics for SLC22A23 Gene

Regulatory Elements for SLC22A23 Gene

Enhancers for SLC22A23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H003377 2 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +75.5 75531 8.9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 YY1 SLC30A9 SLC22A23 PSMG4 PRPF4B ENSG00000272320 ENSG00000228170 C6orf201 GC06M003358 GC06M003328
GH06H003401 2 FANTOM5 Ensembl ENCODE dbSUPER 14.8 +50.0 49987 11 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 YY1 SLC30A9 SLC22A23 SERPINB6 C6orf201 BPHL TUBB2B GC06M003358 LOC105374890
GH06H003337 1.6 Ensembl ENCODE dbSUPER 11.1 +117.1 117063 5.5 HDGF PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF766 FOS JUNB REST PRPF4B PSMG4 C6orf201 SLC22A23 RIPK1 TUBB2B ENSG00000272320 WRNIP1 GC06M003328 GC06M003358
GH06H003412 1.4 Ensembl ENCODE dbSUPER 12.2 +42.8 42824 3 ELF3 FOXA2 ARID4B RAD21 ZSCAN9 RARA ZSCAN5C ZNF207 RUNX3 MIXL1 SLC22A23 LOC105374890 GC06M003429
GH06H003421 1.3 Ensembl ENCODE dbSUPER 12.7 +33.7 33693 3.5 PKNOX1 ZBTB40 ETS1 ZNF366 FOS IKZF2 EGR2 SMARCA5 MAFF IKZF1 SLC22A23 SERPINB1 GC06M003429 LOC105374890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC22A23 on UCSC Golden Path with GeneCards custom track

Promoters for SLC22A23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000192253 222 1601 ARID4B DMAP1 ZNF2 GLIS2 ZNF143 SP3 SP5 MXD4 PPARG NFIL3

Genomic Locations for SLC22A23 Gene

Genomic Locations for SLC22A23 Gene
188,061 bases
Minus strand

Genomic View for SLC22A23 Gene

Genes around SLC22A23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A23 Gene

Proteins for SLC22A23 Gene

  • Protein details for SLC22A23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 22 member 23
    Protein Accession:
    Secondary Accessions:
    • A1A5C8
    • Q5T8B8
    • Q6ZMH3
    • Q8IW73

    Protein attributes for SLC22A23 Gene

    686 amino acids
    Molecular mass:
    73748 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18753.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12303.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A23 Gene


neXtProt entry for SLC22A23 Gene

Post-translational modifications for SLC22A23 Gene

  • Glycosylation at isoforms=424, Thr143, and isoforms=4279
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A23 Gene

Domains & Families for SLC22A23 Gene

Gene Families for SLC22A23 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A23 Gene

Suggested Antigen Peptide Sequences for SLC22A23 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A23: view

Function for SLC22A23 Gene

Phenotypes From GWAS Catalog for SLC22A23 Gene

Gene Ontology (GO) - Molecular Function for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008514 organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A23: view
genes like me logo Genes that share phenotypes with SLC22A23: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A23 Gene

Localization for SLC22A23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A23 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A23 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC22A23: view

Pathways & Interactions for SLC22A23 Gene

SuperPathways for SLC22A23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC22A23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015711 organic anion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A23: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A23 Gene

Drugs & Compounds for SLC22A23 Gene

No Compound Related Data Available

Transcripts for SLC22A23 Gene

Unigene Clusters for SLC22A23 Gene

Solute carrier family 22, member 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A23 Gene

No ASD Table

Relevant External Links for SLC22A23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC22A23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC22A23 Gene

This gene is overexpressed in Fetal Brain (49.3) and Frontal cortex (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A23 Gene

Protein tissue co-expression partners for SLC22A23 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC22A23 Gene:


SOURCE GeneReport for Unigene cluster for SLC22A23 Gene:


Evidence on tissue expression from TISSUES for SLC22A23 Gene

  • Intestine(4.2)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with SLC22A23: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A23 Gene

Orthologs for SLC22A23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC22A23 33 34
  • 98.3 (n)
(Canis familiaris)
Mammalia SLC22A23 33 34
  • 91.69 (n)
(Rattus norvegicus)
Mammalia Slc22a23 33
  • 89.23 (n)
(Mus musculus)
Mammalia Slc22a23 33 16 34
  • 89.18 (n)
(Bos Taurus)
Mammalia SLC22A23 33 34
  • 87.41 (n)
(Monodelphis domestica)
Mammalia SLC22A23 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SLC22A23 34
  • 59 (a)
(Gallus gallus)
Aves SLC22A23 33 34
  • 79.16 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
-- 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a23 33
  • 68.41 (n)
(Danio rerio)
Actinopterygii SLC22A23 (2 of 3) 34
  • 60 (a)
SLC22A23 (3 of 3) 34
  • 47 (a)
SLC22A23 (1 of 3) 34
  • 38 (a)
Species where no ortholog for SLC22A23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A23 Gene

Gene Tree for SLC22A23 (if available)
Gene Tree for SLC22A23 (if available)

Paralogs for SLC22A23 Gene

Paralogs for SLC22A23 Gene

(4) SIMAP similar genes for SLC22A23 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC22A23: view

Variants for SLC22A23 Gene

Sequence variations from dbSNP and Humsavar for SLC22A23 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000017346 -- 3,405,481(+) CTTCA(C/T)CCAAA intron-variant
rs1000058134 -- 3,283,963(+) TGACG(C/G)TGTCA intron-variant, nc-transcript-variant, reference, missense
rs1000087012 -- 3,399,056(+) AAACC(A/G)AAAAA intron-variant
rs1000128791 -- 3,379,959(+) GATGC(-/GTGT)GTGTG intron-variant, upstream-variant-2KB
rs1000138111 -- 3,359,440(+) AGATG(C/T)TCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A23 Gene

Variant ID Type Subtype PubMed ID
nsv1074904 CNV deletion 25765185
esv3607931 CNV loss 21293372
esv3607929 CNV gain 21293372
esv2731494 CNV deletion 23290073
esv2731493 CNV deletion 23290073
esv2731492 CNV deletion 23290073
esv2731491 CNV deletion 23290073
esv2678916 CNV deletion 23128226
esv2669587 CNV deletion 23128226
esv2461941 CNV insertion 19546169
esv24289 CNV loss 19812545
esv2167684 CNV deletion 18987734
dgv3257n106 CNV deletion 24896259
dgv1163e214 CNV loss 21293372

Variation tolerance for SLC22A23 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A23 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A23 Gene

Disorders for SLC22A23 Gene

Relevant External Links for SLC22A23

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC22A23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A23 Gene

Publications for SLC22A23 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson JA … Fredriksson R (Genomics 2007) 2 3 4 60
  2. Genome-wide association study of antipsychotic-induced QTc interval prolongation. (PMID: 20921969) Aberg K … van den Oord EJ (The pharmacogenomics journal 2012) 3 45 60
  3. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PMID: 19760754) Törkvist L … Pettersson S (Inflammatory bowel diseases 2010) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PMID: 20886065) Cleynen I … Vermeire S (PloS one 2010) 3 45 60

Products for SLC22A23 Gene

Sources for SLC22A23 Gene

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