SLC22A23 Gene
protein-coding GIFtS: 46
GCID: GC06M003269
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solute carrier family 22, member 23(Previous name: chromosome 6 open reading frame 85 )
(Previous symbol: C6orf85)
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Aliases
for SLC22A23 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 22, Member 231 2 | | C6orf851 2 3 5 | | FLJ221741 | | Chromosome 6 Open Reading Frame 851 | | Ion Transporter Protein2 | | Solute Carrier Family 22 Member 232 |
Export aliases for SLC22A23 gene to outside databasesPrevious GC identifers: GC06M003216 GC06M003147 |
Summaries
for SLC22A23 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC22A23:
SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiportersto transport organic ions across cell membranes (Jacobsson et al., 2007 (PubMed 17714910)).(supplied by OMIM, Mar2008)
|
Genomic Views
for SLC22A23 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC22A23 gene promoter:
Sox5 SREBP-1c Egr-4 Arnt SREBP-1b PPAR-gamma1 SREBP-1a PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC22A23
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A23 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p25.2 Ensembl cytogenetic band: 6p25.2 HGNC cytogenetic band: 6p25.2SLC22A23 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M003269: view genomic region
(about GC identifiers)
Start:
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3,269,196 bp from pter |
End:
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3,457,256 bp from pter |
Size:
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188,061 bases |
Orientation:
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minus strand |
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Proteins
for SLC22A23 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S22AN_HUMAN, A1A5C7 (See
protein sequence)Recommended Name: Solute carrier family 22 member 23 Size: 686 amino acids; 73748 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAD18753.1; Type=Erroneous initiation; Sequence=CAI12303.1; Type=Erroneous gene modelprediction; Sequence=CAI40959.1; Type=Erroneous gene model prediction;
Secondary accessions: A1A5C8 Q5T8B8 Q6ZMH3 Q8IW73Alternative splicing: 4 isoforms: A1A5C7-1 A1A5C7-2 A1A5C7-3 A1A5C7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC22A23: NX_A1A5C7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A1A5C7
SLC22A23 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_056297.1 NP_068764.3
ENSEMBL proteins: ENSP00000410245 ENSP00000385028 ENSP00000417737 ENSP00000369657 ENSP00000419463 ENSP00000418134 ENSP00000418985 ENSP00000369653
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC22A23 for ontologies About GeneDecksing
SLC22A23 Antibody Products:
Assay Products for SLC22A23: |
Protein
Domains /
Families
for SLC22A23 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC22A23 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A1A5C7ProtoNet protein and cluster: A1A5C7 UniProtKB/Swiss-Prot: S22AN_HUMAN, A1A5C7Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family |
Function
for SLC22A23 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A23 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A23 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SLC22A23 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A23 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A23 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0022857 | transmembrane transporter activity |
IEA | -- |
SLC22A23 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC22A23:
|
Pathways & Interactions
for SLC22A23 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC22A23
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SLC22A23 (ENSP000003850284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- |
SLC22A23 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC22A23 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC22A23
Search CenterWatch for drugs/clinical trials and news about SLC22A23 / S22AN
|
Transcripts
for SLC22A23 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC22A23 gene (2 alternative transcripts): NM_015482.1 NM_021945.5 Unigene Cluster for SLC22A23: Solute carrier family 22, member 23 Hs.713588 [show with all ESTs]Unigene Representative Sequence: NM_01548212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000436008(uc003mvn.3 uc003mvo.3 uc003mvm.3) ENST00000406686(uc010jnn.3)
ENST00000497691(uc003mvp.1) ENST00000380302 ENST00000490273 ENST00000482874
ENST00000485307 ENST00000467177 ENST00000467144 ENST00000496753 ENST00000380298(uc010jno.2)
ENST00000433689
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A23 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A23 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC22A23 (NM_021945) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC22A23 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A23 |
Additional cDNA sequence: AJ420525.1 AK000691.1 AK025033.1 AK025827.1 AK172770.1 AK225936.1 AK308282.1 AK308943.1 AL110245.1 AL512737.1 BC022217.1 BC038748.1 BC040876.1 BC090851.1 BC128580.1 BC128581.1 12 DOTS entries: DT.100787177 DT.97781715 DT.453023 DT.100017740 DT.95273920 DT.121379727 DT.121379756 DT.121380013 DT.40109362 DT.95246442 DT.121379781 DT.95273924 24/198 AceView cDNA sequences (see all 198): AI867904 Z41786 AI888634 BU739429 AI446649 BM980165 BM993128 CD722175 W80733 CR610126 AI632136 CB161497 AW291160 AI362326 NM_021945 AW136148 Z45225 AL110245 AA339438 AK172770 AI989962 F05032 BC040876 BF062357
GeneLoc Exon Structure
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Expression
for SLC22A23 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC22A23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTCGCATC
About this image
See SLC22A23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC22A23
SOURCE GeneReport for Unigene cluster: Hs.713588
SABiosciences Custom PCR Arrays for SLC22A23
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A23
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC22A23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A23 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A23 |
Orthologs
for SLC22A23 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC22A23 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for SLC22A23 (if available)
TreeFam Gene Tree for SLC22A23 (if available) |
Paralogs
for SLC22A23 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC22A23 gene
- SLC22A172
4 SIMAP similar genes for SLC22A23 using alignment to 6 protein entries: S22AN_HUMAN (see all proteins):DKFZp434F011 SLC22A10 SLC22A17 SLC22A31
SLC22A23 for paralogs About GeneDecksing
|
Genomic Variants
for SLC22A23 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC22A23 (3269196 - 3457256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC22A23
2 CNVs: 99408 69307 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A23 |
|
Disorders
/ Diseases
for SLC22A23 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC22A23 for disorders About GeneDecksing
OMIM gene information: 611697
OMIM disorders: --
5  diseases for SLC22A23: About MalaCardswolf-hirschhorn syndrome ankylosing spondylitis ulcerative colitis spondylitis
crohn's disease
1 disease from the University of Copenhagen DISEASES database for SLC22A23:Wolf-Hirschhorn syndrome Human Genome Epidemiology (HuGE) Navigator: SLC22A23 (9 documents)
Export disorders for SLC22A23 gene to outside databases
|
Publications
for SLC22A23 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC22A23 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SLC22A23) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PubMed id 17714910)1, 2, 3 Jacobsson J.A.... Fredriksson R. (2007)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-wide association study of antipsychotic-induce d QTc interval prolongation. (PubMed id 20921969)1 Aberg K....van den Oord E.J. (2010)
- Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. (PubMed id 21072187)1 Laukens D....De Vos M. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Analysis of 39 Crohn's disease risk loci in Swedish i nflammatory bowel disease patients. (PubMed id 19760754)1 TAPrkvist L....Pettersson S. (2010)
- Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1 Franke A....Parkes M. (2010)
- Molecular reclassification of Crohn's disease by clus ter analysis of genetic variants. (PubMed id 20886065)1 Cleynen I....Vermeire S. (2010)
- Genetic Risk Profiling And Prediction Of Disease Course In Crohn'S Disease Patients. (PubMed id 19422935)1 Henckaerts L....Vermeire S. (2009)
- Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1 Weersma R.K....Vermeire S. (2009)
|
External Searches for SLC22A23 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC22A23 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC22A23 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC22A23 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC22A23 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC22A23 gene:
Search GeneIP for patents involving SLC22A23
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC22A23 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC22A23 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A23 | | | OriGene Protein Over-expression Lysate for SLC22A23 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC22A23 | | OriGene 3'-UTR Clone for SLC22A23 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A23 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A23 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC22A23 | | OriGene Custom Protein Services for SLC22A23 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC22A23 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A23 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A23 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC22A23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A23 |
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 | | | SLC22A23 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A23 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC22A23 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A23 |
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