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Aliases for SLC22A20 Gene

Aliases for SLC22A20 Gene

  • Solute Carrier Family 22 Member 20 2 3 5
  • Organic Anion Transporter 6 3 4
  • OAT6 3 4
  • Solute Carrier Family 22, Member 20 2

External Ids for SLC22A20 Gene

Previous GeneCards Identifiers for SLC22A20 Gene

  • GC11P064739
  • GC11P064981
  • GC11P061308

Summaries for SLC22A20 Gene

Entrez Gene Summary for SLC22A20 Gene

  • SLC22A20 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC22A20 Gene

SLC22A20 (Solute Carrier Family 22 Member 20) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC22A20 Gene

  • Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A20 Gene

Genomics for SLC22A20 Gene

Regulatory Elements for SLC22A20 Gene

Enhancers for SLC22A20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065377 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +168.6 168642 10.3 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ENSG00000254461 LOC105369352 KAT5 NEAT1 DPF2 LOC728975 KLC2 SSSCA1-AS1 SNX15 ZFPL1
GH11G065174 0.8 ENCODE 7.9 -39.2 -39193 1.0 HDAC1 HDGF PKNOX1 ATF1 FOXA2 NFRKB DDX20 SIN3A ZBTB40 POLR2A SLC22A20 SPDYC PGAM1P8
GH11G065115 1.4 ENCODE dbSUPER 4.5 -96.5 -96477 3.5 MLX AGO1 DMAP1 YY1 ZNF143 SP3 TBX21 ZFP41 MEF2D ZNF610 SAC3D1 SYVN1 LOC728975 SNX15 SLC22A20 ZNHIT2 ENSG00000255173
GH11G065442 1.5 Ensembl ENCODE dbSUPER 4.2 +230.4 230391 10.7 HNRNPUL1 PKNOX1 AGO1 SIN3A YY1 TCF12 ZNF121 GLIS2 ZNF143 ZNF207 NEAT1 FRMD8 SLC25A45 MALAT1 ENSG00000255478 TIGD3 CDC42EP2 LOC101927789 LOC728975 BANF1
GH11G065119 1.2 ENCODE 4.5 -92.2 -92177 3.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC LOC728975 SLC22A20 BANF1 MRPL49 ENSG00000278952
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC22A20 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A20 Gene

Chromosome:
11
Start:
65,213,840 bp from pter
End:
65,242,757 bp from pter
Size:
28,918 bases
Orientation:
Plus strand

Genomic View for SLC22A20 Gene

Genes around SLC22A20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A20 Gene

Proteins for SLC22A20 Gene

  • Protein details for SLC22A20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK97-S22AK_HUMAN
    Recommended name:
    Solute carrier family 22 member 20
    Protein Accession:
    A6NK97
    Secondary Accessions:
    • B9EJB2
    • Q6ZN88

    Protein attributes for SLC22A20 Gene

    Size:
    555 amino acids
    Molecular mass:
    60459 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18487.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A20 Gene

Post-translational modifications for SLC22A20 Gene

  • Glycosylation at Asn54 and Asn114
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A20 Gene

No data available for DME Specific Peptides for SLC22A20 Gene

Domains & Families for SLC22A20 Gene

Gene Families for SLC22A20 Gene

HGNC:
IUPHAR :

Protein Domains for SLC22A20 Gene

Suggested Antigen Peptide Sequences for SLC22A20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NK97

UniProtKB/Swiss-Prot:

S22AK_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A20: view

Function for SLC22A20 Gene

Molecular function for SLC22A20 Gene

UniProtKB/Swiss-Prot Function:
Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity).

Gene Ontology (GO) - Molecular Function for SLC22A20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0015143 urate transmembrane transporter activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC22A20: view

Phenotypes for SLC22A20 Gene

genes like me logo Genes that share phenotypes with SLC22A20: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A20

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A20 Gene

Localization for SLC22A20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A20 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SLC22A20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with SLC22A20: view

No data available for Subcellular locations from COMPARTMENTS for SLC22A20 Gene

Pathways & Interactions for SLC22A20 Gene

SuperPathways for SLC22A20 Gene

No Data Available

Interacting Proteins for SLC22A20 Gene

Selected Interacting proteins: A6NK97-S22AK_HUMAN for SLC22A20 Gene via IID

Symbol External ID(s) Details
NDUFA13

Gene Ontology (GO) - Biological Process for SLC22A20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015698 inorganic anion transport IEA --
GO:0015747 urate transport IBA --
GO:0043252 sodium-independent organic anion transport IBA --
GO:1903825 organic acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A20: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A20 Gene

Transcripts for SLC22A20 Gene

mRNA/cDNA for SLC22A20 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A20 Gene

Solute carrier family 22, member 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A20 Gene

No ASD Table

Relevant External Links for SLC22A20 Gene

GeneLoc Exon Structure for
SLC22A20
ECgene alternative splicing isoforms for
SLC22A20

Expression for SLC22A20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A20 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A20 Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.9).

Protein differential expression in normal tissues from HIPED for SLC22A20 Gene

This gene is overexpressed in Adipocyte (36.3) and Fetal testis (32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A20 Gene



Protein tissue co-expression partners for SLC22A20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC22A20 Gene:

SLC22A20

SOURCE GeneReport for Unigene cluster for SLC22A20 Gene:

Hs.532372
genes like me logo Genes that share expression patterns with SLC22A20: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A20 Gene

Orthologs for SLC22A20 Gene

Evolution for SLC22A20 Gene

ENSEMBL:
Gene Tree for SLC22A20 (if available)
TreeFam:
Gene Tree for SLC22A20 (if available)

No data available for Orthologs for SLC22A20 Gene

Paralogs for SLC22A20 Gene

(15) SIMAP similar genes for SLC22A20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC22A20: view

No data available for Paralogs for SLC22A20 Gene

Variants for SLC22A20 Gene

Sequence variations from dbSNP and Humsavar for SLC22A20 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000042482 -- 65,241,611(+) AATAG(C/T)GCCCA intron-variant
rs1000048720 -- 65,237,217(+) GGCTT(C/T)TTCAC intron-variant, utr-variant-3-prime
rs1000150227 -- 65,226,700(+) TAGAA(C/G)CTACC intron-variant, downstream-variant-500B
rs1000203362 -- 65,221,256(+) TGACC(G/T)GGGCT intron-variant
rs1000259425 -- 65,240,590(+) TGAGC(C/T)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A20 Gene

Variant ID Type Subtype PubMed ID
dgv666n106 CNV deletion 24896259
nsv1069594 CNV deletion 25765185
nsv526181 CNV gain 19592680
nsv832190 CNV loss 17160897
nsv951015 CNV deletion 24416366

Relevant External Links for SLC22A20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SLC22A20 Gene

Disorders for SLC22A20 Gene

Relevant External Links for SLC22A20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A20

No disorders were found for SLC22A20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A20 Gene

Publications for SLC22A20 Gene

  1. Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). (PMID: 16478971) Schnabolk G.W. … Sweet D.H. (Am. J. Physiol. Renal Physiol. 2006) 2 3 64
  2. Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. (PMID: 15369770) Monte J.C. … Nigam S.K. (Biochem. Biophys. Res. Commun. 2004) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3 64
  5. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3 64

Products for SLC22A20 Gene

Sources for SLC22A20 Gene

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