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Aliases for SLC22A20 Gene

Aliases for SLC22A20 Gene

  • Solute Carrier Family 22, Member 20 2 3
  • Oat6 3 4 6
  • Organic Anion Transporter 6 3 4
  • Solute Carrier Family 22 Member 20 3

External Ids for SLC22A20 Gene

Previous GeneCards Identifiers for SLC22A20 Gene

  • GC11P064739
  • GC11P064981
  • GC11P061308

Summaries for SLC22A20 Gene

Entrez Gene Summary for SLC22A20 Gene

  • SLC22A20 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC22A20 Gene

SLC22A20 (Solute Carrier Family 22, Member 20) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC22A20 Gene

  • Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A20 Gene

Genomics for SLC22A20 Gene

Regulatory Elements for SLC22A20 Gene

Genomic Location for SLC22A20 Gene

Start:
65,213,840 bp from pter
End:
65,242,757 bp from pter
Size:
28,918 bases
Orientation:
Plus strand

Genomic View for SLC22A20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A20 Gene

Proteins for SLC22A20 Gene

  • Protein details for SLC22A20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK97-S22AK_HUMAN
    Recommended name:
    Solute carrier family 22 member 20
    Protein Accession:
    A6NK97
    Secondary Accessions:
    • B9EJB2
    • Q6ZN88

    Protein attributes for SLC22A20 Gene

    Size:
    555 amino acids
    Molecular mass:
    60459 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18487.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A20 Gene

Proteomics data for SLC22A20 Gene at MOPED

Post-translational modifications for SLC22A20 Gene

  • Glycosylation at Asn54 and Asn114
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A20 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A20 Gene

Domains for SLC22A20 Gene

Gene Families for SLC22A20 Gene

Protein Domains for SLC22A20 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NK97

UniProtKB/Swiss-Prot:

S22AK_HUMAN :
  • A6NK97
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A20: view

Function for SLC22A20 Gene

Molecular function for SLC22A20 Gene

UniProtKB/Swiss-Prot Function: Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity).

Gene Ontology (GO) - Molecular Function for SLC22A20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A20: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC22A20 Gene

Localization for SLC22A20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A20 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A20 Gene COMPARTMENTS Subcellular localization image for SLC22A20 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC22A20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A20: view

Pathways for SLC22A20 Gene

SuperPathways for SLC22A20 Gene

No Data Available

Interacting Proteins for SLC22A20 Gene

Gene Ontology (GO) - Biological Process for SLC22A20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A20: view

No data available for Pathways by source for SLC22A20 Gene

Transcripts for SLC22A20 Gene

mRNA/cDNA for SLC22A20 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A20 Gene

Solute carrier family 22, member 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A20 Gene

No ASD Table

Relevant External Links for SLC22A20 Gene

GeneLoc Exon Structure for
SLC22A20
ECgene alternative splicing isoforms for
SLC22A20

Expression for SLC22A20 Gene

mRNA expression in normal human tissues for SLC22A20 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A20 Gene

This gene is overexpressed in Brain - Cerebellum (5.0) and Brain - Cerebellar Hemisphere (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC22A20 Gene

SOURCE GeneReport for Unigene cluster for SLC22A20 Gene Hs.532372

genes like me logo Genes that share expressions with SLC22A20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC22A20 Gene

Orthologs for SLC22A20 Gene

Evolution for SLC22A20 Gene

ENSEMBL:
Gene Tree for SLC22A20 (if available)
TreeFam:
Gene Tree for SLC22A20 (if available)

No data available for Orthologs for SLC22A20 Gene

Paralogs for SLC22A20 Gene

Selected SIMAP similar genes for SLC22A20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC22A20: view

No data available for Paralogs for SLC22A20 Gene

Variants for SLC22A20 Gene

Sequence variations from dbSNP and Humsavar for SLC22A20 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs171193 -- 65,215,128(-) AAGGT(C/T)GAAGC intron-variant
rs180964 -- 65,216,392(+) gagtg(A/G)atgag intron-variant
rs184734 -- 65,214,732(+) CATTT(C/T)TCTTT intron-variant
rs239251 -- 65,216,560(+) gggtg(A/G)atgag intron-variant
rs239252 -- 65,216,684(+) gagtc(A/G)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A20 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
nsv897713 CNV Loss 21882294
nsv832190 CNV Loss 17160897

Relevant External Links for SLC22A20 Gene

HapMap Linkage Disequilibrium report
SLC22A20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A20 Gene

Disorders for SLC22A20 Gene

No disorders were found for SLC22A20 Gene.

No data available for UniProtKB/Swiss-Prot for SLC22A20 Gene

Publications for SLC22A20 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. (PMID: 15369770) Monte J.C. … Nigam S.K. (Biochem. Biophys. Res. Commun. 2004) 2 3
  3. Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). (PMID: 16478971) Schnabolk G.W. … Sweet D.H. (Am. J. Physiol. Renal Physiol. 2006) 2 3
  4. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SLC22A20 Gene

Sources for SLC22A20 Gene

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