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Aliases for SLC22A2 Gene

Aliases for SLC22A2 Gene

  • Solute Carrier Family 22 (Organic Cation Transporter), Member 2 2 3
  • OCT2 3 4 6
  • Organic Cation Transporter 2 3 4
  • Solute Carrier Family 22 Member 2 3
  • HOCT2 4

External Ids for SLC22A2 Gene

Previous GeneCards Identifiers for SLC22A2 Gene

  • GC06M160077
  • GC06M160511
  • GC06M160547
  • GC06M160608
  • GC06M160557
  • GC06M160592
  • GC06M158107

Summaries for SLC22A2 Gene

Entrez Gene Summary for SLC22A2 Gene

  • Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A2 Gene

SLC22A2 (Solute Carrier Family 22 (Organic Cation Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC22A2 include choriocarcinoma. Among its related pathways are Metabolism and PEDF Induced Signaling. GO annotations related to this gene include steroid binding and quaternary ammonium group transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A2 Gene

  • Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

Gene Wiki entry for SLC22A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A2 Gene

Genomics for SLC22A2 Gene

Regulatory Elements for SLC22A2 Gene

Genomic Location for SLC22A2 Gene

Start:
160,171,061 bp from pter
End:
160,277,638 bp from pter
Size:
106,578 bases
Orientation:
Minus strand

Genomic View for SLC22A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A2 Gene

Proteins for SLC22A2 Gene

  • Protein details for SLC22A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15244-S22A2_HUMAN
    Recommended name:
    Solute carrier family 22 member 2
    Protein Accession:
    O15244
    Secondary Accessions:
    • Q5T7Q6
    • Q6PIQ8
    • Q8NG62
    • Q9NQB9

    Protein attributes for SLC22A2 Gene

    Size:
    555 amino acids
    Molecular mass:
    62581 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A2 Gene

Proteomics data for SLC22A2 Gene at MOPED

Post-translational modifications for SLC22A2 Gene

  • Glycosylation at Asn72
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A2 Gene

Domains for SLC22A2 Gene

Gene Families for SLC22A2 Gene

Protein Domains for SLC22A2 Gene

Suggested Antigen Peptide Sequences for SLC22A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15244

UniProtKB/Swiss-Prot:

S22A2_HUMAN :
  • O15244
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A2: view

Function for SLC22A2 Gene

Molecular function for SLC22A2 Gene

GENATLAS Biochemistry: solute carrier family 22,member A2,polyspecific transporter oforganic cations,mainly expressed in kidney (luminal membrane of distal tube)
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1 mM for agmatine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=95 uM for amiloride {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=24 uM for ASP {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=34 uM for memantine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=27 uM for amantadine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=1.38 mM for metformin {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=1.9 mM for noradrenaline {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=1.9 mM for norepinephrine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=1.3 mM for histamine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=0.39 mM for dopamine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=0.08 mM for serotonine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=72.6 uM for cimetidine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=56.1 uM for famotidine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=65.2 uM for ranitidine {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=431 uM for TEA (isoform 1) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; KM=63 uM for TEA (isoform 2) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=3770 pmol/min/mg enzyme for TEA uptake (isoform 1) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=314 pmol/min/mg enzyme for TEA uptake (isoform 2) {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=11.9 nmol/min/mg enzyme for metformin uptake {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=2170 pmol/min/mg enzyme for cimetidine uptake {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=204 pmol/min/mg enzyme for famotidine uptake {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576}; Vmax=265 pmol/min/mg enzyme for ranitidine uptake {ECO:0000269 PubMed:11758759, ECO:0000269 PubMed:12089365, ECO:0000269 PubMed:12538837, ECO:0000269 PubMed:15783073, ECO:0000269 PubMed:16006492, ECO:0000269 PubMed:16272756, ECO:0000269 PubMed:16394027, ECO:0000269 PubMed:9687576};
UniProtKB/Swiss-Prot Function: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
UniProtKB/Swiss-Prot Induction: May be down-regulated in diabetic patients.

Gene Ontology (GO) - Molecular Function for SLC22A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005496 steroid binding IEA --
GO:0015075 ion transmembrane transporter activity --
GO:0015101 organic cation transmembrane transporter activity IDA 16024787
GO:0015220 choline transmembrane transporter activity IEA --
GO:0015651 quaternary ammonium group transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A2: view

Phenotypes for SLC22A2 Gene

genes like me logo Genes that share phenotypes with SLC22A2: view

Animal Models for SLC22A2 Gene

MGI Knock Outs for SLC22A2:

miRNA for SLC22A2 Gene

miRTarBase miRNAs that target SLC22A2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC22A2 Gene

Localization for SLC22A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A2 Gene COMPARTMENTS Subcellular localization image for SLC22A2 gene
Compartment Confidence
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC22A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane TAS 9260930
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC22A2: view

Pathways for SLC22A2 Gene

genes like me logo Genes that share pathways with SLC22A2: view

Interacting Proteins for SLC22A2 Gene

Gene Ontology (GO) - Biological Process for SLC22A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006855 drug transmembrane transport TAS --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0007589 body fluid secretion TAS 9260930
genes like me logo Genes that share ontologies with SLC22A2: view

Compounds for SLC22A2 Gene

(55) Drugbank Compounds for SLC22A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Agmatine
306-60-5 transporter substrate
Amantadine
  • 1-aminoadamantane
768-94-5 transporter inhibitor
Amiloride
  • Amilorida [INN-Spanish]
2016-88-8 transporter inhibitor
Aminoguanidine
79-17-4 transporter inhibitor
Aminohippurate
  • Aminohippurate Sodium
94-16-6 transporter inhibitor

(57) Novoseek inferred chemical compound relationships for SLC22A2 Gene

Compound -log(P) Hits PubMed IDs
1 methyl 4 phenylpyridinium 84.9 11
tetraethylammonium 84.4 15
cimetidine 82 11
cyanine 863 80.8 2
deoxytubercidin 79.1 1

(7) PharmGKB related drug/compound annotations for SLC22A2 Gene

genes like me logo Genes that share compounds with SLC22A2: view

Transcripts for SLC22A2 Gene

Unigene Clusters for SLC22A2 Gene

Solute carrier family 22 (organic cation transporter), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: -
SP3:

Relevant External Links for SLC22A2 Gene

GeneLoc Exon Structure for
SLC22A2
ECgene alternative splicing isoforms for
SLC22A2

Expression for SLC22A2 Gene

mRNA expression in normal human tissues for SLC22A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A2 Gene

This gene is overexpressed in Kidney - Cortex (47.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC22A2 Gene

SOURCE GeneReport for Unigene cluster for SLC22A2 Gene Hs.436385

mRNA Expression by UniProt/SwissProt for SLC22A2 Gene

O15244-S22A2_HUMAN
Tissue specificity: Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma.
genes like me logo Genes that share expressions with SLC22A2: view

Orthologs for SLC22A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC22A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A2 35
  • 99.44 (n)
  • 99.07 (a)
SLC22A2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A2 35
  • 84.58 (n)
  • 86.7 (a)
SLC22A2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A2 35
  • 84.37 (n)
  • 84.62 (a)
SLC22A2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a2 35
  • 83.06 (n)
  • 83.85 (a)
Slc22a2 16
Slc22a2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A2 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a2 35
  • 81.51 (n)
  • 82.19 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 69 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
SLC22A2 35
  • 71.31 (n)
  • 70.51 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC68647 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487774 35
  • 62.66 (n)
  • 62.66 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13231 35
slc22a2 35
  • 56.23 (n)
  • 50.64 (a)
slc22a2 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4630 36
  • 28 (a)
ManyToMany
CG7442 36
  • 27 (a)
ManyToMany
CG7458 36
  • 25 (a)
ManyToMany
CG3790 37
  • 30 (a)
CG17751 37
  • 27 (a)
CG8654 37
  • 30 (a)
CG16727 37
  • 27 (a)
CG5592 37
  • 29 (a)
CG7458 37
  • 26 (a)
CG13610 37
  • 32 (a)
CG7084 37
  • 26 (a)
CG4630 37
  • 30 (a)
CG6126 37
  • 28 (a)
CG17752 37
  • 26 (a)
CG9317 37
  • 31 (a)
CG7442 37
  • 28 (a)
CG6231 37
  • 26 (a)
CG6356 37
  • 25 (a)
Orct 37
  • 33 (a)
CG6600 37
  • 31 (a)
CG7333 37
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea F52F12.1a 37
  • 31 (a)
K05F1.6 37
  • 24 (a)
oct-1 37
  • 31 (a)
Y82E9BR.16 37
  • 27 (a)
ZK455.8a 37
  • 26 (a)
B0252.3 37
  • 27 (a)
ZK455.8b 37
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO84 38
Species with no ortholog for SLC22A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC22A2 Gene

ENSEMBL:
Gene Tree for SLC22A2 (if available)
TreeFam:
Gene Tree for SLC22A2 (if available)

Paralogs for SLC22A2 Gene

Selected SIMAP similar genes for SLC22A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC22A2: view

Variants for SLC22A2 Gene

Sequence variations from dbSNP and Humsavar for SLC22A2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs315978 -- 160,231,826(+) tccta(C/T)gctgg intron-variant
rs315979 -- 160,232,895(+) ttctt(G/T)gacca intron-variant
rs315980 -- 160,232,949(+) atttc(A/G)tagtc intron-variant
rs315981 -- 160,233,393(+) tggaa(A/C)cttca intron-variant
rs315982 -- 160,233,982(+) gtata(C/T)atcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A2 Gene

Variant ID Type Subtype PubMed ID
dgv2024e1 CNV Complex 17122850
esv35098 CNV Gain 17911159
nsv818463 CNV Gain 17921354
nsv509159 CNV Insertion 20534489
nsv886808 CNV Loss 21882294
esv2660610 CNV Deletion 23128226
esv2421683 CNV Deletion 20811451
nsv520963 CNV Loss 19592680
esv2433457 CNV Deletion 19546169
esv2669393 CNV Deletion 23128226
esv23439 CNV Loss 19812545
dgv7013n71 CNV Gain 21882294

Relevant External Links for SLC22A2 Gene

HapMap Linkage Disequilibrium report
SLC22A2
Human Gene Mutation Database (HGMD)
SLC22A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A2 Gene

Disorders for SLC22A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC22A2 Gene including...

Search for SLC22A2 Gene in MalaCards »

(13) Novoseek inferred disease relationships for SLC22A2 Gene

Disease -log(P) Hits PubMed IDs
carnitine deficiency, primary 79.7 1
hodgkin disease 49.4 7
cholestasis 35.2 2
lymphoma b-cell 32.3 2
choriocarcinoma 28.8 1

Relevant External Links for SLC22A2

Genetic Association Database (GAD)
SLC22A2
Human Genome Epidemiology (HuGE) Navigator
SLC22A2
genes like me logo Genes that share disorders with SLC22A2: view

No data available for UniProtKB/Swiss-Prot for SLC22A2 Gene

Publications for SLC22A2 Gene

  1. Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin. (PMID: 17111267) Shikata E. … Ieiri I. (J. Hum. Genet. 2007) 3 4 23 48
  2. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). (PMID: 12538837) Grundemann D. … Schomig E. (J. Pharmacol. Exp. Ther. 2003) 3 4 23 25
  3. Organic cation transporters are determinants of oxaliplatin cytotoxicity. (PMID: 16951202) Zhang S. … Giacomini K.M. (Cancer Res. 2006) 3 4 23
  4. Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. (PMID: 16314463) Ciarimboli G. … Schlatter E. (Am. J. Pathol. 2005) 3 4 23
  5. The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. (PMID: 9605850) Koehler M.R. … Schmid M. (Cytogenet. Cell Genet. 1997) 2 3 23

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