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SLC22A2 Gene

protein-coding   GIFtS: 62
GCID: GC06M160592

Solute Carrier Family 22 (Organic Cation Transporter), Member...

  See SLC22A2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22 (Organic Cation Transporter), Member 21 2
OCT22 3 5
Organic Cation Transporter 22 3
Solute Carrier Family 22 Member 22
hOCT23

External Ids:    HGNC: 109661   Entrez Gene: 65822   Ensembl: ENSG000001124997   OMIM: 6026085   UniProtKB: O152443   

Export aliases for SLC22A2 gene to outside databases

Previous GC identifers: GC06M160077 GC06M160511 GC06M160547 GC06M160608 GC06M160557 GC06M158107


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A2 Gene:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for
elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins.
This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded
protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found
primarily in the kidney, where it may mediate the first step in cation reabsorption. (provided by RefSeq, Jul
2008)

GeneCards Summary for SLC22A2 Gene:
SLC22A2 (solute carrier family 22 (organic cation transporter), member 2) is a protein-coding gene. Diseases associated with SLC22A2 include choriocarcinoma. GO annotations related to this gene include quaternary ammonium group transmembrane transporter activity and steroid binding. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22A2_HUMAN, O15244
Function: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine,
dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine,
amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin,
N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin
and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by
fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of
oxaliplatin and may contribute to antitumor specificity

Gene Wiki entry for SLC22A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A2 gene promoter:
         ATF-2   Bach2   XBP-1   NF-kappaB   Roaz   YY1   Evi-1   S8   NF-kappaB1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A2 promoter sequence
   Search Chromatin IP Primers for SLC22A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

SLC22A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M160592:  view genomic region     (about GC identifiers)

Start:
160,592,093 bp from pter      End:
160,698,670 bp from pter
Size:
106,578 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S22A2_HUMAN, O15244 (See protein sequence)
Recommended Name: Solute carrier family 22 member 2  
Size: 555 amino acids; 62581 Da
Secondary accessions: Q5T7Q6 Q6PIQ8 Q8NG62 Q9NQB9
Alternative splicing: 3 isoforms:  O15244-1   O15244-2   O15244-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC22A2: NX_O15244

Explore proteomics data for SLC22A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn72
  • Modification sites at PhosphoSitePlus

  • See SLC22A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003049.2  
    ENSEMBL proteins: 
     ENSP00000355920   ENSP00000355919  
    Reactome Protein details: O15244

    SLC22A2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC22A2 

     
    antibodies-online proteins for SLC22A2 (3 products) 

     
    antibodies-online peptides for SLC22A2

    SLC22A2 Antibody Products:

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    antibodies-online kits for SLC22A2 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic cation transporter 2
    Organic cation transporters (OCT)

    5 InterPro protein domains:
     IPR004749 Orgcat_transp
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry O15244

    ProtoNet protein and cluster: O15244

    1 Blocks protein domain: IPB005829 Sugar transporter superfamily

    UniProtKB/Swiss-Prot: S22A2_HUMAN, O15244
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22A2_HUMAN, O15244
    Function: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine,
    dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine,
    amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin,
    N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin
    and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by
    fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of
    oxaliplatin and may contribute to antitumor specificity
    Biophysicochemical properties: Kinetic parameters: KM=1 mM for agmatine; KM=95 uM for amiloride; KM=24 uM for ASP;
    KM=34 uM for memantine; KM=27 uM for amantadine; KM=1.38 mM for metformin; KM=1.9 mM for noradrenaline; KM=1.9 mM
    for norepinephrine; KM=1.3 mM for histamine; KM=0.39 mM for dopamine; KM=0.08 mM for serotonine; KM=72.6 uM for
    cimetidine (at pH 7.4 and 37 degrees Celsius); KM=56.1 uM for famotidine; KM=65.2 uM for ranitidine; KM=431 uM
    for TEA (isoform 1); KM=63 uM for TEA (isoform 2); Vmax=3770 pmol/min/mg enzyme for TEA uptake (isoform 1);
    Vmax=314 pmol/min/mg enzyme for TEA uptake (isoform 2); Vmax=11.9 nmol/min/mg enzyme for metformin uptake;
    Vmax=2170 pmol/min/mg enzyme for cimetidine uptake; Vmax=204 pmol/min/mg enzyme for famotidine uptake; Vmax=265
    pmol/min/mg enzyme for ranitidine uptake;
    Induction: May be down-regulated in diabetic patients

         Genatlas biochemistry entry for SLC22A2:
    solute carrier family 22,member A2,polyspecific transporter oforganic cations,mainly expressed in kidney (luminal
    membrane of distal tube)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005496steroid binding IEA--
    GO:0008513secondary active organic cation transmembrane transporter activity ----
    GO:0015075ion transmembrane transporter activity ----
    GO:0015101organic cation transmembrane transporter activity IDA16024787
    GO:0015220choline transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC22A2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc22a2):
     homeostasis/metabolism  normal  renal/urinary system 

    Find genes that share phenotypes with SLC22A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SLC22A2: Slc22a2tm1Ahs Slc22a2tm2Ahs

       genOway: Develop your customized and physiologically relevant rodent model for SLC22A2

    miRNA
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    miRTarBase miRNAs that target SLC22A2:
    hsa-mir-335-5p (MIRT017635)

    Block miRNA regulation of human, mouse, rat SLC22A2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC22A2:
    hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22A2_HUMAN, O15244: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane TAS9260930
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IEA--

    Find genes that share ontologies with SLC22A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC22A2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Na+/Cl- dependent neurotransmitter transporters0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Organic cation transport0.00
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neurotransmitter Clearance In The Synaptic Cleft0.00
    Neuronal System0.68
    3Neurotransmitter Release Cycle
    Neurotransmitter Release Cycle0.32
    Norepinephrine Neurotransmitter Release Cycle0.00
    4Abacavir transport and metabolism
    Abacavir transport and metabolism
    Abacavir transmembrane transport0.00
    5PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43


    Find genes that share SuperPaths with SLC22A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC22A2
        Glucocorticoid Receptor Signaling

    5 Reactome Pathways for SLC22A2
        Neurotransmitter Clearance In The Synaptic Cleft
    Norepinephrine Neurotransmitter Release Cycle
    Na+/Cl- dependent neurotransmitter transporters
    Organic cation transport
    Abacavir transmembrane transport

    2 PharmGKB Pathways for SLC22A2
        Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Metformin Pathway, Pharmacokinetics

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC22A2: 
              Drug Transporters in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC22A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for SLC22A2 (ENSP000003559204) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB1ENSP000002657244STRING: ENSP00000265724
    ABCG2ENSP000002376124STRING: ENSP00000237612
    MAOAENSP000003406844STRING: ENSP00000340684
    SLC18A2ENSP000002984724STRING: ENSP00000298472
    CPLX1ENSP000003056134STRING: ENSP00000305613
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006855drug transmembrane transport TAS--
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007589body fluid secretion TAS9260930

    Find genes that share ontologies with SLC22A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A2 (S22A2)

    Selected DrugBank Compounds for SLC22A2 (see all 55)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CholineBilineurine (see all 7)62-49-7transportersubstrate inhibitor19886673 9260930 11502595 11758759 10082798 12176030 11553644 12089365 10889205
    Cimetidine-- 51481-61-9transportersubstrate inhibitor10385678 10082798 10220855 10960071 12176030 9808712 12089365 10592235 15496291
    DopamineDopamin (see all 6)51-61-6transportersubstrate inhibitor9830022 10385678 9687576 11758759 9812985 12089365 9933568
    Procainamide-- 51-06-9transporterinhibitor12438515 9260930 11502595 15640376 11758759 12176030 12089365
    Quinine6'-Methoxycinchonidine (see all 6)130-95-0transporterinhibitor12438515 9260930 11502595 10600936 12176030 11553644
    GuanidineAminomethanamidine (see all 9)113-00-8transporterinhibitor10385678 11502595 9808712 12089365 10592235
    Histamine Phosphate-- 51-74-1transportersubstrate inhibitor10385678 11502595 9687576 11758759 12089365
    Amantadine1-aminoadamantane (see all 9)768-94-5transporterinhibitor12438515 15640376 9687576 12089365
    Metformin-- 657-24-9transportersubstrate inhibitor16272756 19915604 12240953 10592235
    NorepinephrineArterenol (see all 4)51-41-2transportersubstrate inhibitor9830022 9687576 9812985 12089365

    Selected Novoseek inferred chemical compound relationships for SLC22A2 gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1 methyl 4 phenylpyridinium 84.9 21 10385678 (3), 17018840 (1), 16722235 (1), 12675912 (1) (see all 9)
    tetraethylammonium 84.4 24 9685390 (1), 16756089 (1), 19771738 (1), 2204428 (1) (see all 15)
    cimetidine 82 17 18551044 (2), 16006492 (1), 19251820 (1), 14960416 (1) (see all 10)
    cyanine 863 80.8 3 14960416 (1), 12657510 (1)
    deoxytubercidin 79.1 1 9950964 (1)
    moxa 78.9 2 15028572 (1), 11414662 (1)
    carnitine 78.5 43 16288981 (1), 17084519 (1), 20027113 (1), 12889657 (1) (see all 28)
    oatp 77.4 19 11901224 (6), 19661216 (1), 20381614 (1), 14598019 (1) (see all 7)
    metformin 77.2 76 19483665 (5), 18728938 (4), 17111267 (4), 19536068 (3) (see all 18)
    quinidine 71.6 3 16904877 (1), 8415403 (1), 19528813 (1)

    7 PharmGKB related drug/compound annotations for SLC22A2 gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    l-tryptophanCA  
    metforminCA  
    ranolazine
    sulfamethoxazole
    trimethoprim
    vandetanib



    Find genes that share compounds with SLC22A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A2 gene (2 alternative transcripts): 
    NM_003058.3  NM_153191.1  

    Unigene Cluster for SLC22A2:

    Solute carrier family 22 (organic cation transporter), member 2
    Hs.436385  [show with all ESTs]
    Unigene Representative Sequence: AB075951
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486916 ENST00000366953(uc003qtf.3 uc003qth.2) ENST00000498556
    ENST00000491092 ENST00000366952 ENST00000489644
    miRNA
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    hsa-miR-3658
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC22A2
      QuantiFast Probe-based Assays in human, mouse, rat SLC22A2

    Additional mRNA sequence: 

    AB075951.1 AK290787.1 BC030978.1 BC039899.1 X98333.1 

    4 DOTS entries:

    DT.75101960  DT.100744089  DT.99949895  DT.91756666 

    Selected AceView cDNA sequences (see all 45):

    BE464249 BI762264 NM_153191 CR618035 BE326996 BX092360 BE465218 NM_003058 
    BF434956 AI793252 AI253257 AI627509 AI207329 AW300623 BX109288 BI761325 
    AI253100 AL544105 AI565378 AI793077 AI767306 AW779330 BC030978 AI564091 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                -                                                   
    SP2:                                -                                                   
    SP3:                                                                                    


    ECgene alternative splicing isoforms for SLC22A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATTATAA
    SLC22A2 Expression
    About this image


    SLC22A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Meninges
     
     Kidney (Urinary System)
    SLC22A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436385

    UniProtKB/Swiss-Prot: S22A2_HUMAN, O15244
    Tissue specificity: Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of
    kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in
    various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells
    in the stroma

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC22A2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a21 , 5 solute carrier family 22 (organic cation transporter), more1, 5 83.06(n)1
    83.85(a)1
      17 (8.61 cM)5
    205181  NM_013667.21  NP_038695.11 
     125841895 
    chicken
    (Gallus gallus)
    Aves SLC22A21 solute carrier family 22 (organic cation transporter), more 71.31(n)
    70.51(a)
      421583  XM_419621.4  XP_419621.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    68(a)
    62(a)
    many ↔ many
    many ↔ many
    1(211874719-211897469)
    1(211901351-211922466)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686472 hypothetical protein MGC68647 74.06(n)    BC061664.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.132312 Danio rerio cDNA clone MGC64076 IMAGE6794502, complete more 71.61(n)    BC054608.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Orct3 carnitine transporter 33(a)
    (best of 18)
      95F8   --


    ENSEMBL Gene Tree for SLC22A2 (if available)
    TreeFam Gene Tree for SLC22A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A2 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A102  SLC22A132  
    SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A32  SLC22A252  
    14 SIMAP similar genes for SLC22A2 using alignment to 2 protein entries:     S22A2_HUMAN (see all proteins):
    SLC22A1    SLC22A3    SVOP    SLC22A5    SLC22A4    SLC22A13
    SLC22A8    SLC22A12    SLC22A6    SLC22A11    SLC22A16    SLC22A24
    SLC22A10    SLC22A7

    Find genes that share paralogs with SLC22A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A2 (see all 1144)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs781651831,2
    C,F--160637329(+) AAGGAA/GGCATA 1 -- ds50013Minor allele frequency- G:0.05CSA WA 121
    rs765920431,2
    C,F--160637360(+) TCAGTG/ATTAAT 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1875691931,2
    --160637393(+) AGTATG/TTGATT 1 -- ds50010--------
    rs5958531,2
    C,A--160637485(-) tataaA/Cagata 1 -- ds50017Minor allele frequency- C:0.05WA NA CSA EA 366
    rs5953741,2
    C,F,A--160637562(-) ctccaC/Tatata 1 -- ds500111Minor allele frequency- T:0.27NA WA CSA EA 493
    rs1425848601,2
    --160637648(+) AAGGAA/CATTTT 1 -- ds50010--------
    rs1925636381,2
    --160637668(+) ATAAGA/TCTTAT 1 -- ds50010--------
    rs1460085941,2
    --160637682(+) ATTTAG/TCTTTT 1 -- ds50010--------
    rs31275921,2
    C,F,A,H--160637844(+) GAAAAT/CACACA 1 -- ut31 ese317Minor allele frequency- C:0.11NS EA WA CSA NA 2740
    rs6948121,2
    C,F,A,H--160637890(-) TAAGTA/GATCAT 1 -- ut3134Minor allele frequency- G:0.16MN NS EA NA WA CSA 3965

    HapMap Linkage Disequilibrium report for SLC22A2 (160592093 - 160698670 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC22A2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660610CNV Deletion23128226
    esv2421683CNV Deletion20811451
    esv2669393CNV Deletion23128226
    esv2433457CNV Deletion19546169
    nsv509159CNV Insertion20534489
    nsv886808CNV Loss21882294
    nsv520963CNV Loss19592680
    esv23439CNV Loss19812545
    dgv7013n71CNV Gain21882294
    nsv818463CNV Gain17921354

    Human Gene Mutation Database (HGMD): SLC22A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602608    OMIM disorders: --

    1 disease for SLC22A2:    
    About MalaCards
    choriocarcinoma


    Find genes that share disorders with SLC22A2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SLC22A2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carnitine deficiency, primary 79.7 1 20027113 (1)
    hodgkin disease 49.4 10 16648862 (2), 17562619 (1), 11154228 (1), 11280769 (1) (see all 6)
    cholestasis 35.2 4 19002567 (2)
    lymphoma b-cell 32.3 2 16185500 (1), 15202521 (1)
    choriocarcinoma 28.8 1 17174940 (1)
    lymphoma non-hodgkins 9.27 2 16648862 (2)
    cardiomyopathy 8.59 1 15125729 (1)
    lymphoma 6.6 5 16185500 (4)
    breast cancer 2.66 3 19949573 (1), 19220984 (1), 19950388 (1)
    renal failure 0.645 2 16085315 (1), 16580907 (1)

    Genetic Association Database (GAD): SLC22A2
    Human Genome Epidemiology (HuGE) Navigator: SLC22A2 (22 documents)

    Export disorders for SLC22A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A2 gene, integrated from 10 sources (see all 328):
    (articles sorted by number of sources associating them with SLC22A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). (PubMed id 12538837)1, 2, 7, 9 Grundemann D.... Schomig E. (J. Pharmacol. Exp. Ther. 2003)
    2. Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin. (PubMed id 17111267)1, 2, 4, 9 Shikata E....Ieiri I. (J. Hum. Genet. 2007)
    3. cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. (PubMed id 12089365)1, 2, 7 Urakami Y.... Inui K. (J. Am. Soc. Nephrol. 2002)
    4. Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. (PubMed id 9687576)1, 2, 7 Busch A.E.... Koepsell H. (Mol. Pharmacol. 1998)
    5. Cloning and characterization of two human polyspecific organic cation transporters. (PubMed id 9260930)1, 2, 7 Gorboulev V.... Koepsell H. (DNA Cell Biol. 1997)
    6. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. (PubMed id 19483665)1, 4, 9 Chen Y....Giacomini K.M. (Pharmacogenet. Genomics 2009)
    7. OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. (PubMed id 18551044)1, 4, 9 Wang Z.J....Chow M.S. (Pharmacogenet. Genomics 2008)
    8. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. (PubMed id 12142729)1, 2, 9 Leabman M.K....Giacomini K.M. (Pharmacogenetics 2002)
    9. Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. (PubMed id 10942111)1, 2, 9 Gruendemann D. and Schoemig E. (Hum. Genet. 2000)
    10. Genetic variants of the organic cation transporter 2 influence the disposition of metformin. (PubMed id 18401339)1, 4, 9 Song I.S....Shin J.G. (Clin. Pharmacol. Ther. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6582 HGNC: 10966 AceView: SLC22A2 Ensembl:ENSG00000112499 euGenes: HUgn6582
    ECgene: SLC22A2 H-InvDB: SLC22A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A2 gene:
    Search GeneIP for patents involving SLC22A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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