SLC22A18AS Gene
protein-coding GIFtS: 39
GCID: GC11M002911
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solute carrier family 22 (organic cation transporter), member...(Previous names: solute carrier family 22 (organic cation transporter),...)
(Previous symbols: BWSCR1B, ORCTL2S, SLC22A1LS)
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Aliases
for SLC22A18AS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 22 (Organic Cation Transporter), Member 18Antisense1 2 | | Solute Carrier Family 22 Member 1-Like Antisense Protein2 3 | | BWSCR1B1 2 3 5 | | Solute Carrier Family 22 Member 18 Antisense Protein2 3 | | ORCTL2S1 2 3 5 | | P27-Beckwith-Wiedemann Region 1 B2 3 | | SLC22A1LS1 2 3 5 | | Beckwith-Wiedemann Region 1B2 | | BWR1B1 2 3 | | Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene B Protein2 | | P27-BWR1B1 | | Beckwith-Wiedemann Syndrome Chromosome Region 1, Candidate B2 | | Solute Carrier Family 22 (Organic Cation Transporter), Member 1-Like Antisense1 2 | | Organic Cation Transporter-Like 2 Antisense2 | | Organic Cation Transporter-Like Protein 2 Antisense Protein2 3 | | |
Export aliases for SLC22A18AS gene to outside databasesPrevious GC identifers: GC11M002866 GC11M002697 GC11M002910 |
Summaries
for SLC22A18AS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC22A18AS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC22A18AS gene promoter:
c-Fos RP58 RFX1 AP-1 Pax-5 NRSF form 2 YY1 MZF-1 Zic1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC22A18AS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A18AS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5SLC22A18AS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M002911: view genomic region
(about GC identifiers)
Start:
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2,909,010 bp from pter |
End:
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2,925,175 bp from pter |
Size:
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16,166 bases |
Orientation:
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minus strand |
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Proteins
for SLC22A18AS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BWR1B_HUMAN, Q8N1D0 (See
protein sequence)Recommended Name: Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein Size: 253 amino acids; 27061 Da
Secondary accessions: E9PLK8 O43563Alternative splicing: 2 isoforms: Q8N1D0-1 Q8N1D0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC22A18AS: NX_Q8N1D0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N1D0
SLC22A18AS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009036.2
ENSEMBL proteins: ENSP00000433282 ENSP00000435592 ENSP00000434027
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
SLC22A18AS for ontologies About GeneDecksing
SLC22A18AS Antibody Products:
Assay Products for SLC22A18AS: |
Protein
Domains /
Families
for SLC22A18AS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8N1D0 |
Function
for SLC22A18AS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A18AS
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A18AS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A18AS |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
SLC22A18AS for ontologies About GeneDecksing
|
Pathways & Interactions
for SLC22A18AS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC22A18AS
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
SLC22A18AS for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC22A18AS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC22A18AS
Search CenterWatch for drugs/clinical trials and news about SLC22A18AS / BWR1B
|
Transcripts
for SLC22A18AS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC22A18AS gene: NM_007105.2 Unigene Cluster for SLC22A18AS: Solute carrier family 22 (organic cation transporter), member 18 antisense Hs.300076 [show with all ESTs]Unigene Representative Sequence: NM_0071053 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000533594(uc001lwv.4 uc001lww.4) ENST00000526203 ENST00000455942
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A18AS
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A18AS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC22A18AS (NM_007105) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC22A18AS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A18AS |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A18AS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLC22A18AS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A18AS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A18AS |
Additional cDNA sequence: AF035407.1 AF037066.1 BC030237.1 3 DOTS entries: DT.110771 DT.100000075 DT.99964859 24/28 AceView cDNA sequences (see all 28): AA568717 AI344199 AI360403 AI249702 CB129046 AI143559 AF035407 R07294 BF591336 BF590806 AA887729 BV192729 AA480374 AF037066 NM_007105 N35348 BC030237 AI198427 BU602253 AW188584 AW772496 BU631006 BX092944 AI869930
GeneLoc Exon Structure
|
Expression
for SLC22A18AS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC22A18AS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACAAGGG
About this image
See SLC22A18AS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC22A18AS
SOURCE GeneReport for Unigene cluster: Hs.300076
UniProtKB/Swiss-Prot: BWR1B_HUMAN, Q8N1D0Tissue specificity: Most abundantly expressed in gastrointestinal tissues. Expressed at lower levels in kidney andplacenta. Expressed in fetal brain, liver, placenta, kidney and lung
SABiosciences Custom PCR Arrays for SLC22A18AS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A18AS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLC22A18AS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A18AS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A18AS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A18AS |
Orthologs
for SLC22A18AS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SLC22A18AS (if available)
TreeFam Gene Tree for SLC22A18AS (if available) |
Paralogs
for SLC22A18AS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SLC22A18AS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC22A18AS (2909010 - 2925175 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SLC22A18AS
4 CNVs: 29898 29899 3832 4730 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SLC22A18AS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC22A18AS for disorders About GeneDecksing
OMIM gene information: 603240
OMIM disorders: --
1  disease for SLC22A18AS: About MalaCardsbeckwith-wiedemann syndrome
Human Genome Epidemiology (HuGE) Navigator: SLC22A18AS (1 document)
Export disorders for SLC22A18AS gene to outside databases
|
Publications
for SLC22A18AS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC22A18AS gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC22A18AS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Paternal imprinting of the SLC22A1LS gene located in the human chromosome segment 11p15.5. (PubMed id 15175115)1, 2, 3, 9 Bajaj V....Kumar A. (2004)
- Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. (PubMed id 9570947)1, 2, 3, 9 Cooper P.R....Higgins M.J. (1998)
- Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. (PubMed id 9520460)1, 2, 3 Schwienbacher C.... Negrini M. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS. (PubMed id 18721868)1, 9 Bajaj V....Kumar A. (2008)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of a novel single nucleotide polymorphism (SNP) in the human organic cation transporter-like 2-antisense (ORCTL2S) gene. (PubMed id 10697966)9 Higashimoto K....Mukai T. (2000)
|
External Searches for SLC22A18AS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC22A18AS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC22A18AS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC22A18AS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC22A18AS | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC22A18AS gene:
Search GeneIP for patents involving SLC22A18AS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC22A18AS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC22A18AS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC22A18AS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A18AS | | | OriGene Protein Over-expression Lysate for SLC22A18AS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC22A18AS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A18AS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A18AS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC22A18AS | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A18AS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A18AS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC22A18AS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A18AS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A18AS |
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 | | | SLC22A18AS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A18AS |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A18AS |
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