Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC22A18AS Gene

Aliases for SLC22A18AS Gene

  • Solute Carrier Family 22 Member 18 Antisense 2 3 5
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 1-Like Antisense 2 3
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 18 Antisense 2 3
  • Organic Cation Transporter-Like Protein 2 Antisense Protein 3 4
  • Solute Carrier Family 22 Member 1-Like Antisense Protein 3 4
  • Solute Carrier Family 22 Member 18 Antisense Protein 3 4
  • P27-Beckwith-Wiedemann Region 1 B 3 4
  • SLC22A1LS 3 4
  • P27-BWR1B 3 4
  • BWSCR1B 3 4
  • ORCTL2S 3 4
  • BWR1B 3 4
  • Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene B Protein 3
  • Beckwith-Wiedemann Syndrome Chromosome Region 1, Candidate B 3
  • Organic Cation Transporter-Like 2 Antisense 3
  • Beckwith-Wiedemann Region 1B 3

External Ids for SLC22A18AS Gene

Previous HGNC Symbols for SLC22A18AS Gene

  • BWSCR1B
  • ORCTL2S
  • SLC22A1LS

Previous GeneCards Identifiers for SLC22A18AS Gene

  • GC11M002866
  • GC11M002697
  • GC11M002910
  • GC11M002911
  • GC11M002915

Summaries for SLC22A18AS Gene

GeneCards Summary for SLC22A18AS Gene

SLC22A18AS (Solute Carrier Family 22 Member 18 Antisense) is a Protein Coding gene. Diseases associated with SLC22A18AS include Beckwith-Wiedemann Syndrome.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A18AS Gene

Genomics for SLC22A18AS Gene

Regulatory Elements for SLC22A18AS Gene

Enhancers for SLC22A18AS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G002939 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -37.0 -37029 2.0 GTF2F1 PKNOX1 AGO1 MAX BMI1 RAD21 ZNF316 POLR2A HNF4G RCOR1 NAP1L4 ENSG00000183562 SLC22A18AS SNORA54 SLC22A18 KCNQ1 PHLDA2 KCNQ1-AS1 GC11M002963 GC11M002964
GH11G002901 1.3 ENCODE dbSUPER 9.7 +0.9 889 4.1 PKNOX1 ATF1 AGO1 ARID4B SIN3A YY1 GLIS2 ELK1 ZNF207 KLF13 SLC22A18 SLC22A18AS
GH11G002537 0.9 ENCODE dbSUPER 11.8 +364.8 364774 2.9 SOX5 SOX13 BHLHE40 CEBPB TEAD3 MIER3 IKZF1 GABPB1 NR2F6 SMAD4 CDKN1C SLC22A18AS SLC22A18 PHLDA2 NAP1L4 SNORA54 PIR42060 GC11P002540
GH11G002549 0.6 ENCODE dbSUPER 16.3 +353.2 353222 1.6 HNRNPL SLC22A18AS TRPM5 KCNQ1DN KCNQ1-AS1 SLC22A18 CD81 ENSG00000199550 GC11P002540 GC11P002570
GH11G002940 0.5 dbSUPER 11.7 -35.3 -35275 0.4 GLIS1 KDM1A RELB ZNF18 SLC22A18 SLC22A18AS SNORA54 NAP1L4 PHLDA2 GC11M002963 GC11M002964 PIR57698
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC22A18AS on UCSC Golden Path with GeneCards custom track

Promoters for SLC22A18AS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036005 1645 1001 ATF1 ARID4B SIN3A GLIS2 ZNF207 SP3 SP5 NFYC NCOA1 REST

Genomic Location for SLC22A18AS Gene

Chromosome:
11
Start:
2,887,344 bp from pter
End:
2,903,945 bp from pter
Size:
16,602 bases
Orientation:
Minus strand

Genomic View for SLC22A18AS Gene

Genes around SLC22A18AS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A18AS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A18AS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A18AS Gene

Proteins for SLC22A18AS Gene

  • Protein details for SLC22A18AS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1D0-BWR1B_HUMAN
    Recommended name:
    Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein
    Protein Accession:
    Q8N1D0
    Secondary Accessions:
    • E9PLK8
    • O43563

    Protein attributes for SLC22A18AS Gene

    Size:
    253 amino acids
    Molecular mass:
    27061 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A18AS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A18AS Gene

Post-translational modifications for SLC22A18AS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC22A18AS Gene

Domains & Families for SLC22A18AS Gene

Protein Domains for SLC22A18AS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A18AS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SLC22A18AS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SLC22A18AS Gene

Function for SLC22A18AS Gene

Gene Ontology (GO) - Molecular Function for SLC22A18AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLC22A18AS: view
genes like me logo Genes that share phenotypes with SLC22A18AS: view

Animal Model Products

CRISPR Products

miRNA for SLC22A18AS Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A18AS Gene

Localization for SLC22A18AS Gene

Gene Ontology (GO) - Cellular Components for SLC22A18AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SLC22A18AS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for SLC22A18AS Gene

Pathways & Interactions for SLC22A18AS Gene

SuperPathways for SLC22A18AS Gene

No Data Available

Interacting Proteins for SLC22A18AS Gene

Gene Ontology (GO) - Biological Process for SLC22A18AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SLC22A18AS: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A18AS Gene

Drugs & Compounds for SLC22A18AS Gene

No Compound Related Data Available

Transcripts for SLC22A18AS Gene

Unigene Clusters for SLC22A18AS Gene

Solute carrier family 22 (organic cation transporter), member 18 antisense:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A18AS Gene

No ASD Table

Relevant External Links for SLC22A18AS Gene

GeneLoc Exon Structure for
SLC22A18AS
ECgene alternative splicing isoforms for
SLC22A18AS

Expression for SLC22A18AS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A18AS Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A18AS Gene

This gene is overexpressed in Colon - Transverse (x11.7), Kidney - Cortex (x6.8), and Liver (x5.7).

Protein differential expression in normal tissues from HIPED for SLC22A18AS Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A18AS Gene



Protein tissue co-expression partners for SLC22A18AS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC22A18AS Gene:

SLC22A18AS

SOURCE GeneReport for Unigene cluster for SLC22A18AS Gene:

Hs.300076

mRNA Expression by UniProt/SwissProt for SLC22A18AS Gene:

Q8N1D0-BWR1B_HUMAN
Tissue specificity: Most abundantly expressed in gastrointestinal tissues. Expressed at lower levels in kidney and placenta. Expressed in fetal brain, liver, placenta, kidney and lung.
genes like me logo Genes that share expression patterns with SLC22A18AS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A18AS Gene

Orthologs for SLC22A18AS Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SLC22A18AS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A18AS 34 35
  • 98.81 (n)
Species where no ortholog for SLC22A18AS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC22A18AS Gene

ENSEMBL:
Gene Tree for SLC22A18AS (if available)
TreeFam:
Gene Tree for SLC22A18AS (if available)

Paralogs for SLC22A18AS Gene

No data available for Paralogs for SLC22A18AS Gene

Variants for SLC22A18AS Gene

Sequence variations from dbSNP and Humsavar for SLC22A18AS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000027791 -- 2,891,472(+) TCAAA(C/G/T)CCTCT intron-variant, upstream-variant-2KB
rs1000096226 -- 2,892,393(+) CCGGG(C/T)TGCAG intron-variant, upstream-variant-2KB
rs1000232774 -- 2,894,247(+) AAGCA(C/T)AGGCC intron-variant
rs1000438831 -- 2,905,479(+) TCCAG(C/T)TTCAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000563600 -- 2,895,634(+) GGCCA(C/G)GAGTT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC22A18AS Gene

Variant ID Type Subtype PubMed ID
dgv1574n54 CNV loss 21841781
dgv1575n54 CNV loss 21841781
dgv1576n54 CNV loss 21841781
esv2181696 CNV deletion 18987734
esv2744015 CNV deletion 23290073
esv2759795 CNV gain 17122850
nsv1070931 CNV deletion 25765185
nsv467655 CNV loss 19166990
nsv467657 CNV loss 19166990
nsv467658 CNV loss 19166990
nsv469930 CNV loss 18288195
nsv553111 CNV loss 21841781
nsv553119 CNV loss 21841781
nsv553120 CNV loss 21841781
nsv825715 CNV gain 20364138
nsv832050 CNV loss 17160897
nsv951292 CNV deletion 24416366

Variation tolerance for SLC22A18AS Gene

Gene Damage Index Score: 2.41; 42.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A18AS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A18AS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A18AS Gene

Disorders for SLC22A18AS Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC22A18AS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC22A18AS

Genetic Association Database (GAD)
SLC22A18AS
Human Genome Epidemiology (HuGE) Navigator
SLC22A18AS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A18AS
genes like me logo Genes that share disorders with SLC22A18AS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A18AS Gene

Publications for SLC22A18AS Gene

  1. Paternal imprinting of the SLC22A1LS gene located in the human chromosome segment 11p15.5. (PMID: 15175115) Bajaj V. … Kumar A. (BMC Genet. 2004) 2 3 4 22 64
  2. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. (PMID: 9570947) Cooper P.R. … Higgins M.J. (Genomics 1998) 2 3 4 22 64
  3. Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. (PMID: 9520460) Schwienbacher C. … Negrini M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
  4. Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS. (PMID: 18721868) Bajaj V. … Kumar A. (Gene 2008) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLC22A18AS Gene

Sources for SLC22A18AS Gene

Content
Loading form....