Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC22A18AS Gene

Aliases for SLC22A18AS Gene

  • Solute Carrier Family 22 (Organic Cation Transporter), Member 18 Antisense 2 3
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 1-Like Antisense 2 3
  • Organic Cation Transporter-Like Protein 2 Antisense Protein 3 4
  • Solute Carrier Family 22 Member 1-Like Antisense Protein 3 4
  • Solute Carrier Family 22 Member 18 Antisense Protein 3 4
  • P27-Beckwith-Wiedemann Region 1 B 3 4
  • SLC22A1LS 3 4
  • P27-BWR1B 3 4
  • BWSCR1B 3 4
  • ORCTL2S 3 4
  • BWR1B 3 4
  • Beckwith-Wiedemann Syndrome Chromosome Region 1, Candidate B 3
  • Organic Cation Transporter-Like 2 Antisense 3
  • Beckwith-Wiedemann Region 1B 3

External Ids for SLC22A18AS Gene

Previous HGNC Symbols for SLC22A18AS Gene

  • BWSCR1B
  • ORCTL2S
  • SLC22A1LS

Previous GeneCards Identifiers for SLC22A18AS Gene

  • GC11M002866
  • GC11M002697
  • GC11M002910
  • GC11M002911
  • GC11M002915

Summaries for SLC22A18AS Gene

GeneCards Summary for SLC22A18AS Gene

SLC22A18AS (Solute Carrier Family 22 (Organic Cation Transporter), Member 18 Antisense) is a Protein Coding gene. Diseases associated with SLC22A18AS include beckwith-wiedemann syndrome.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A18AS Gene

Genomics for SLC22A18AS Gene

Regulatory Elements for SLC22A18AS Gene

Genomic Location for SLC22A18AS Gene

Chromosome:
11
Start:
2,887,344 bp from pter
End:
2,903,945 bp from pter
Size:
16,602 bases
Orientation:
Minus strand

Genomic View for SLC22A18AS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SLC22A18AS Gene

Proteins for SLC22A18AS Gene

  • Protein details for SLC22A18AS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1D0-BWR1B_HUMAN
    Recommended name:
    Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein
    Protein Accession:
    Q8N1D0
    Secondary Accessions:
    • E9PLK8
    • O43563

    Protein attributes for SLC22A18AS Gene

    Size:
    253 amino acids
    Molecular mass:
    27061 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A18AS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A18AS Gene

Proteomics data for SLC22A18AS Gene at MOPED

Post-translational modifications for SLC22A18AS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC22A18AS Gene

No data available for DME Specific Peptides for SLC22A18AS Gene

Domains & Families for SLC22A18AS Gene

Protein Domains for SLC22A18AS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A18AS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SLC22A18AS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SLC22A18AS Gene

Function for SLC22A18AS Gene

Gene Ontology (GO) - Molecular Function for SLC22A18AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLC22A18AS: view

Phenotypes for SLC22A18AS Gene

GenomeRNAi human phenotypes for SLC22A18AS:
genes like me logo Genes that share phenotypes with SLC22A18AS: view

Animal Model Products

CRISPR Products

miRNA for SLC22A18AS Gene

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLC22A18AS
    • Block miRNA regulation of SLC22A18AS using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A18AS

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A18AS Gene

    Localization for SLC22A18AS Gene

    Gene Ontology (GO) - Cellular Components for SLC22A18AS Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005575 cellular_component ND --
    genes like me logo Genes that share ontologies with SLC22A18AS: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for SLC22A18AS Gene

    Pathways & Interactions for SLC22A18AS Gene

    SuperPathways for SLC22A18AS Gene

    No Data Available

    Interacting Proteins for SLC22A18AS Gene

    Gene Ontology (GO) - Biological Process for SLC22A18AS Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0008150 biological_process ND --
    genes like me logo Genes that share ontologies with SLC22A18AS: view

    No data available for Pathways by source and SIGNOR curated interactions for SLC22A18AS Gene

    Drugs & Compounds for SLC22A18AS Gene

    No Compound Related Data Available

    Transcripts for SLC22A18AS Gene

    mRNA/cDNA for SLC22A18AS Gene

    Unigene Clusters for SLC22A18AS Gene

    Solute carrier family 22 (organic cation transporter), member 18 antisense:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate SLC22A18AS
      • Block miRNA regulation of SLC22A18AS using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A18AS

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A18AS Gene

      No ASD Table

      Relevant External Links for SLC22A18AS Gene

      GeneLoc Exon Structure for
      SLC22A18AS
      ECgene alternative splicing isoforms for
      SLC22A18AS

      Expression for SLC22A18AS Gene

      mRNA expression in normal human tissues for SLC22A18AS Gene

      mRNA differential expression in normal tissues according to GTEx for SLC22A18AS Gene

      This gene is overexpressed in Colon - Transverse (x11.7), Kidney - Cortex (x6.8), and Liver (x5.7).

      Protein differential expression in normal tissues from HIPED for SLC22A18AS Gene

      This gene is overexpressed in Urine (69.0).

      Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A18AS Gene



      SOURCE GeneReport for Unigene cluster for SLC22A18AS Gene Hs.300076

      mRNA Expression by UniProt/SwissProt for SLC22A18AS Gene

      Q8N1D0-BWR1B_HUMAN
      Tissue specificity: Most abundantly expressed in gastrointestinal tissues. Expressed at lower levels in kidney and placenta. Expressed in fetal brain, liver, placenta, kidney and lung.
      genes like me logo Genes that share expression patterns with SLC22A18AS: view

      Protein tissue co-expression partners for SLC22A18AS Gene

      - Elite partner

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC22A18AS Gene

      Orthologs for SLC22A18AS Gene

      This gene was present in the common ancestor of human and chimp.

      Orthologs for SLC22A18AS Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia SLC22A18AS 35
      • 98.81 (n)
      • 98.02 (a)
      SLC22A18AS 36
      • 98 (a)
      OneToOne
      Species with no ortholog for SLC22A18AS:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • cow (Bos Taurus)
      • dog (Canis familiaris)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • mouse (Mus musculus)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for SLC22A18AS Gene

      ENSEMBL:
      Gene Tree for SLC22A18AS (if available)
      TreeFam:
      Gene Tree for SLC22A18AS (if available)

      Paralogs for SLC22A18AS Gene

      No data available for Paralogs for SLC22A18AS Gene

      Variants for SLC22A18AS Gene

      Sequence variations from dbSNP and Humsavar for SLC22A18AS Gene

      SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
      rs763011123 -- 2,891,943(+) CTTCT(-/TTCCTTCA)TTCCT intron-variant
      rs573344308 -- 2,891,943(+) CCTTC(A/T)TTCCT intron-variant
      rs3986786 -- 2,890,871(-) GCCGC(-/GC)ATGTG intron-variant
      rs446396 -- 2,890,303(+) TGGCC(A/C/G/T)TGCCT intron-variant

      Structural Variations from Database of Genomic Variants (DGV) for SLC22A18AS Gene

      Variant ID Type Subtype PubMed ID
      dgv333e1 CNV Complex 17122850
      dgv1006n71 CNV Loss 21882294
      nsv469930 CNV Loss 18288195
      dgv1007n71 CNV Loss 21882294
      dgv1008n71 CNV Loss 21882294
      nsv825715 CNV Gain 20364138
      nsv467655 CNV Loss 19166990
      dgv1009n71 CNV Loss 21882294
      nsv832050 CNV Loss 17160897
      nsv467657 CNV Loss 19166990
      nsv896864 CNV Loss 21882294
      dgv1010n71 CNV Loss 21882294
      dgv1011n71 CNV Loss 21882294
      esv2744015 CNV Deletion 23290073
      esv2181696 CNV Deletion 18987734
      dgv1012n71 CNV Loss 21882294
      dgv1013n71 CNV Loss 21882294
      nsv467658 CNV Loss 19166990

      Variation tolerance for SLC22A18AS Gene

      Gene Damage Index Score: 2.41; 42.58% of all genes are more intolerant (likely to be disease-causing)

      Relevant External Links for SLC22A18AS Gene

      HapMap Linkage Disequilibrium report
      SLC22A18AS

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A18AS Gene

      Disorders for SLC22A18AS Gene

      MalaCards: The human disease database

      (1) MalaCards diseases for SLC22A18AS Gene - From: DISEASES and GeneCards

      Disorder Aliases PubMed IDs
      beckwith-wiedemann syndrome
      • wiedemann-beckwith syndrome
      - elite association

      Relevant External Links for SLC22A18AS

      Genetic Association Database (GAD)
      SLC22A18AS
      Human Genome Epidemiology (HuGE) Navigator
      SLC22A18AS
      Atlas of Genetics and Cytogenetics in Oncology and Haematology:
      SLC22A18AS
      genes like me logo Genes that share disorders with SLC22A18AS: view

      No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A18AS Gene

      Publications for SLC22A18AS Gene

      1. Paternal imprinting of the SLC22A1LS gene located in the human chromosome segment 11p15.5. (PMID: 15175115) Bajaj V. … Kumar A. (BMC Genet. 2004) 2 23 67
      2. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. (PMID: 9570947) Cooper P.R. … Higgins M.J. (Genomics 1998) 2 23 67
      3. Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS. (PMID: 18721868) Bajaj V. … Kumar A. (Gene 2008) 23 67
      4. Identification of a novel single nucleotide polymorphism (SNP) in the human organic cation transporter-like 2-antisense (ORCTL2S) gene. (PMID: 10697966) Higashimoto K. … Mukai T. (J. Hum. Genet. 2000) 23 67
      5. Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. (PMID: 9520460) Schwienbacher C. … Negrini M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 67

      Products for SLC22A18AS Gene

      Sources for SLC22A18AS Gene

      Back to Top

      Content