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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC22A18 Gene

protein-coding   GIFtS: 54
GCID: GC11P002877

solute carrier family 22, member 18

(Previous names: solute carrier family 22 (organic cation transporter),...)
(Previous symbols: ORCTL2, BWSCR1A, IMPT1, SLC22A1L)
 Explore 16 diseases affiliated with
SLC22A18 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC22A18    

Aliases
for SLC22A18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 22, Member 181 2     Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 5 Protein2 3
BWSCR1A1 2 3 5     HET2 3
IMPT11 2 3 5     ORCTL-22 3
SLC22A1L1 2 3 5     P45-BWR1A1
BWR1A1 2 3     P45-Beckwith-Wiedemann Region 1 A2 3
ITM1 2 3     Solute Carrier Family 22 (Organic Cation Transporter), Member 1-Like1
ORCTL21 2 3     Beckwith-Wiedemann Syndrome Chromosome Region 1, Candidate A2
TSSC51 2 3     Imprinted Multi-Membrane Spanning Polyspecific Transporter-Related Protein 12
Beckwith-Wiedemann Syndrome Chromosomal Region 1 Candidate Gene A Protein2 3     Organic Cation Transporter-Like 22
Efflux Transporter-Like Protein2 3     P45 Beckwith-Wiedemann Region 1A2
Imprinted Multi-Membrane-Spanning Polyspecific Transporter-Related Protein 12 3     Solute Carrier Family 22 Member 182
Organic Cation Transporter-Like Protein 22 3     Solute Carrier Family 22 Member 1-Like3
Tumor-Suppressing STF CDNA 5 Protein2 3     

External Ids:    HGNC: 109641   Entrez Gene: 50022   Ensembl: ENSG000001106287   OMIM: 6026315   UniProtKB: Q96BI13   

Export aliases for SLC22A18 gene to outside databases

Previous GC identifers: GC11P002885 GC11P002709


Summaries
for SLC22A18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC22A18:
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of
11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the
Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast
cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have
been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role
in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript
variants encoding the same protein have been described. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: S22AI_HUMAN, Q96BI1
Function: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in
the transport of chloroquine and quinidine-related compounds in kidney

Gene Wiki entry for SLC22A18


Genomic Views
for SLC22A18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC22A18 gene promoter:
         NF-1   SRY   Pax-5   NCX/Ncx   POU6F1 (c2)   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC22A18 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC22A18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

SLC22A18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A18 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002877:  view genomic region     (about GC identifiers)

Start:
 2,920,951 bp from pter      End:
 2,946,476 bp from pter
Size:
 25,526 bases      Orientation:
 plus strand

Proteins
for SLC22A18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S22AI_HUMAN, Q96BI1 (See protein sequence)
Recommended Name: Solute carrier family 22 member 18  
Size: 424 amino acids; 44846 Da
Subunit: Interacts with RNF167
Subcellular location: Apical cell membrane; Multi-pass membrane protein (Potential). Note=Localized at the apical
membrane surface of renal proximal tubules
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
Sequence caution: Sequence=AAB82727.1; Type=Erroneous initiation; Sequence=BAA32779.1; Type=Erroneous initiation;
Secondary accessions: O14906 O43562 O60485 O60680 Q7LDS5 Q7LGF7

Explore the universe of human proteins at neXtProt for SLC22A18: NX_Q96BI1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96BI1

    • SLC22A18 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002546.3  NP_899056.2  

    ENSEMBL proteins: 
     ENSP00000307859   ENSP00000311139   ENSP00000392072   ENSP00000369948   ENSP00000433019  
    Reactome Protein details: Q96BI1
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC22A18 Protein
    Novus Biologicals SLC22A18 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC22A18

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA16314844
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS9499412
    GO:0016324apical plasma membrane IDA9744804
    GO:0044444cytoplasmic part IDA16314844


    SLC22A18 for ontologies           About GeneDecksing



    SLC22A18 Antibody Products: 
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    Uscn ELISAs and CLIAs for SLC22A18

    Protein Domains /
    Families
    for SLC22A18 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC22A18 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020846 MFS_dom
     IPR001958 Tet-R_TetA/multi-R_MdtG
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q96BI1

    ProtoNet protein and cluster: Q96BI1

    UniProtKB/Swiss-Prot: S22AI_HUMAN, Q96BI1
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family


    Function
    for SLC22A18 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S22AI_HUMAN, Q96BI1
    Function: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in
    the transport of chloroquine and quinidine-related compounds in kidney

    miRNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for SLC22A18

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0015238drug transmembrane transporter activity IDA9744804
    GO:0015293symporter activity IEA--
    GO:0031625ubiquitin protein ligase binding IPI16314844


    SLC22A18 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SLC22A18:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for SLC22A18 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Organic cation/anion/zwitterion transport
    		Organic cation/anion/zwitterion transport1.00
    		Organic cation transport0.62

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SLC22A18
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Organic cation/anion/zwitterion transport
    Organic cation transport



    SLC22A18 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC22A18

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLC22A18 (ENSP000003078594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP45ENSP000003333764STRING: ENSP00000333376
    SAFB2ENSP000002525424STRING: ENSP00000252542
    RB1CC1ENSP000000250084STRING: ENSP00000025008
    UBCENSP000003448184STRING: ENSP00000344818
    --ENSP000004069654STRING: ENSP00000406965
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006855drug transmembrane transport IDA9744804
    GO:0007588excretion NAS9744804
    GO:0015695organic cation transport NAS9744804
    GO:0015893drug transport IDA9744804
    GO:0055085transmembrane transport TAS--


    SLC22A18 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC22A18 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC22A18
    Search CenterWatch for drugs/clinical trials and news about SLC22A18 / S22AI 

    Transcripts
    for SLC22A18 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC22A18 gene (2 alternative transcripts): 
    NM_002555.5  NM_183233.2  

    Unigene Cluster for SLC22A18:

    Solute carrier family 22, member 18
    Hs.50868  [show with all ESTs]
    Unigene Representative Sequence: AF030302
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347936(uc001lwx.3) ENST00000312221(uc001lwy.3) ENST00000449793
    ENST00000380574 ENST00000485423 ENST00000492567 ENST00000498244 ENST00000467719
    ENST00000463571 ENST00000498209 ENST00000441077 ENST00000449603 ENST00000495518


    miRNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB012083.1 AF028738.1 AF030302.1 AF037064.1 AF059663.1 AF070479.1 BC015571.2 

    13 DOTS entries:

    DT.113838  DT.110771  DT.91960671  DT.100775722  DT.100775724  DT.100024765  DT.100775723  DT.40130645 
    DT.86853205  DT.95079254  DT.95079257  DT.95079260  DT.99951568 

    24/118 AceView cDNA sequences (see all 118):

    CR611681 AW009530 BM893547 AA535955 CK823231 BF062704 BM966890 BM893589 
    BM893625 BM825077 AI760091 BM966814 BU194065 AF059663 CK823232 BM561526 
    BI761173 BM893646 BQ447434 BM966767 BE671759 CA454177 AI767626 AA737813 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A18 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                      -                       -                       -     -                                 
    SP2:                                                              -                       -     -                                 
    SP3:                                      -                                                                                       
    SP4:                                -     -                       -                                                               
    SP5:                                                              -                                                               


    ECgene alternative splicing isoforms for SLC22A18

    Expression
    for SLC22A18 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC22A18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGGCCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SLC22A18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC22A18

    SOURCE GeneReport for Unigene cluster: Hs.50868

    UniProtKB/Swiss-Prot: S22AI_HUMAN, Q96BI1
    Tissue specificity: Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal
    renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A18

    Orthologs
    for SLC22A18 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC22A18 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC22A181 solute carrier family 22, member 18 59.54(n)
    55.04(a)    		   423089  XM_421021.2  XP_421021.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC22A186
    		 --
    		 54(a)
    		 1 ↔ 1
    		 1(68785844-68866731)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc22a181 solute carrier family 22 (organic cation transporter), more 56.79(n)
    54.12(a)    		   559752  NM_001037385.1  NP_001032462.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C53B4.31 Protein C53B4.3 38.03(n)
    28.73(a)    		   177714  NM_069156.2  NP_501557.2 
    rice
    (Oryza sativa)    		 Liliopsida --
    		 tetracycline transporter-like protein 1, putative,...
    		 12(a)
    		 1 ↔ 1
    		 5(13870216-13871657)


    ENSEMBL Gene Tree for SLC22A18 (if available)
    TreeFam Gene Tree for SLC22A18 (if available) 

    Paralogs
    for SLC22A18 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC22A18 gene
    MFSD92  MFSD102  
    1 SIMAP similar gene for SLC22A18 using alignment to 3 protein entries:     S22AI_HUMAN (see all proteins):
    DKFZp667A184

    SLC22A18 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC22A18 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/664 NCBI SNPs in SLC22A18 are shown (see all 664)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs110244521,2
    		--2707656(+) TCCAGA/GTCACC 1 -- us2k1 tfbs30--------
    rs110244531,2
    		--2707666(+) CCTTCA/TGTCCT 1 -- us2k10--------
    rs79400311,2
    		C,A,--2707694(+) AATGGC/TGAAGG 1 -- us2k10--------
    rs740483741,2
    		C,--2707816(+) GCAGCA/CTCACT 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs740483751,2
    		C,--2708077(+) ACCCAG/CCTCCT 1 -- us2k12Minor allele frequency- C:0.13WA 120
    rs760245401,2
    		C,--2708666(+) CATTTC/TCTTAG 1 -- us2k12Minor allele frequency- T:0.11CSA WA 119
    rs749786621,2
    		C,F,--2708743(+) ACCACC/TAGGCG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs4494771,2
    		H--2708872(+) GTGTAG/TGCAGG 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 424
    rs118240771,2
    		C,F,H,--2709176(+) AATCCG/ATGCTC 1 -- us2k12Minor allele frequency- A:0.06NA WA 122
    rs748400671,2
    		C,F,--2709322(+) CTGAAG/ACNNNN 1 -- us2k12Minor allele frequency- A:0.03WA NA 238

    HapMap Linkage Disequilibrium report for SLC22A18 (2920951 - 2946476 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SLC22A18
         3 CNVs: 29899 3832 4730

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    Disorders / Diseases
    for SLC22A18 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC22A18 for disorders           About GeneDecksing

    OMIM gene information: 602631   
    OMIM disorders: 114480  268210  211980  
    UniProtKB/Swiss-Prot: S22AI_HUMAN, Q96BI1
  • Defects in SLC22A18 are associated with lung cancer (LNCR) [MIM:211980]. LNCR is a common malignancy affecting
    • tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided
    into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often
    diagnosed at an advanced stage and has a poor prognosis
  • Defects in SLC22A18 are a cause of rhabdomyosarcoma type 1 (RMS1) [MIM:268210]. It is a form of
    • rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting
    differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue
    sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal
    rhabdomyosarcomas

    16 diseases for SLC22A18:    About MalaCards
    beckwith-wiedemann syndrome    wilms tumor    rhabdomyosarcoma    breast cancer
    lung cancer    adrenocortical carcinoma    botryoid rhabdomyosarcoma    carcinoma
    soft tissue sarcoma    alcohol dependence    hepatoblastoma    nephroblastoma
    sarcoma    alcoholism    malaria    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for SLC22A18:
    Pain agnosia

    6 Novoseek disease relationships for SLC22A18 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beckwith-wiedemann syndrome 83.1 2 9520460 (1)
    hepatoblastoma 76.3 1 9570947 (1)
    wilms tumor 72.1 3 9751628 (2), 9570947 (1)
    rhabdomyosarcoma 67.4 1 9520460 (1)
    tumors 7.48 10 15239143 (3), 16314844 (2), 9520460 (2), 9751628 (1) (see all 5)
    breast cancer 4.64 2 16624517 (1), 9520460 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC22A18 (1 document)

    Export disorders for SLC22A18 gene to outside databases

    Publications
    for SLC22A18 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC22A18 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with SLC22A18)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. (PubMed id 9499412)1, 2, 3, 9 Dao D....Tycko B. (1998)
    2. Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. (PubMed id 9520460)1, 2, 3, 9 Schwienbacher C.... Negrini M. (1998)
    3. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. (PubMed id 16314844)1, 2, 9 Yamada H.Y. and Gorbsky G.J. (2006)
    4. Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5. (PubMed id 9751628)1, 2, 9 Lee M.P.... Feinberg A.P. (1998)
    5. Functional characterization of ORCTL2 -- an organic cation transporter expressed in the renal proximal tubules. (PubMed id 9744804)1, 2, 9 Reece M.... Pelletier J. (1998)
    6. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. (PubMed id 9570947)1, 2, 9 Cooper P.R....Higgins M.J. (1998)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice. (PubMed id 9802569)1, 2 Morisaki H.... Mukai T. (1998)
    9. Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer. (PubMed id 16624517)1, 9 Gallagher E....Mc Cann A. (2006)
    10. [Expression and its clinical significance of SLC22A18 in non-small cell lung cancer]. (PubMed id 22237119)1 Lei M....Zhang Z. (2012)

    External Searches for SLC22A18 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SLC22A18 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5002 HGNC: 10964 AceView: SLC22A18 Ensembl:ENSG00000110628 euGenes: HUgn5002
    ECgene: SLC22A18 H-InvDB: SLC22A18

    Other Databases showing SLC22A18 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC22A18 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC22A18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC22A18 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SLC22A18 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC22A18 gene:
    Search GeneIP for patents involving SLC22A18

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