Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC22A17 Gene

protein-coding   GIFtS: 48
GCID: GC14M023815

Solute Carrier Family 22, Member 17

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 22, Member 171 2     NGALR22 5
Neutrophil Gelatinase-Associated Lipocalin Receptor1 2 3     NGALR32 5
BOCT2 3 5     hBOIT2
BOIT2 3 5     NGAL Receptor2
Brain-Type Organic Cation Transporter2 3     Potent Brain Type Organic Ion Transporter2
Lipocalin-2 Receptor2 3     Solute Carrier Family 22 (Organic Cation Transporter), Member 172
24p3 Receptor2 3     Solute Carrier Family 22 Member 172
24p3R2 3     NgalR3
NGALR2 5     

External Ids:    HGNC: 230951   Entrez Gene: 513102   Ensembl: ENSG000000920967   OMIM: 6114615   UniProtKB: Q8WUG53   

Export aliases for SLC22A17 gene to outside databases

Previous GC identifers: GC14M021805 GC14M022888 GC14M003931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SLC22A17 Gene:
SLC22A17 (solute carrier family 22, member 17) is a protein-coding gene. Diseases associated with SLC22A17 include esophageal squamous cell carcinoma, and endometrial carcinoma. GO annotations related to this gene include transmembrane signaling receptor activity and transmembrane transporter activity. An important paralog of this gene is SLC22A23.

UniProtKB/Swiss-Prot: S22AH_HUMAN, Q8WUG5
Function: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to
bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby
increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2
(apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore,
leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron
concentration and resulting in apoptosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A17 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A17 promoter sequence
   Search Chromatin IP Primers for SLC22A17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

SLC22A17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A17 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023815:  view genomic region     (about GC identifiers)

Start:
23,815,515 bp from pter      End:
23,822,121 bp from pter
Size:
6,607 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S22AH_HUMAN, Q8WUG5 (See protein sequence)
Recommended Name: Solute carrier family 22 member 17  
Size: 538 amino acids; 57686 Da
Sequence caution: Sequence=CAC01119.1; Type=Erroneous initiation; Sequence=CAC17762.1; Type=Erroneous initiation;
Secondary accessions: A4UA13 A8MUT0 Q2TAB0 Q5BKY8 Q86U04 Q9H1D3 Q9NQD5
Alternative splicing: 3 isoforms:  Q8WUG5-1   Q8WUG5-2   Q8WUG5-3   

Explore the universe of human proteins at neXtProt for SLC22A17: NX_Q8WUG5

Explore proteomics data for SLC22A17 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn23, Asn32
  • Modification sites at PhosphoSitePlus

  • See SLC22A17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001275979.1  NP_057693.3  NP_065105.2  

    ENSEMBL proteins: 
     ENSP00000346824   ENSP00000380430   ENSP00000206544   ENSP00000380437  

    SLC22A17 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC22A17
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC22A17
    GenScript Custom Purified and Recombinant Proteins Services for SLC22A17
    Novus Biologicals SLC22A17 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC22A17

    SLC22A17 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC22A17
    OriGene Custom Antibody Services for SLC22A17
    Novus Biologicals SLC22A17 Antibodies
    Abcam antibodies for SLC22A17
    Cloud-Clone Corp. Antibodies for SLC22A17
    ThermoFisher Antibodies for SLC22A17
    LSBio Antibodies in human, mouse, rat for SLC22A17

    SLC22A17 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC22A17
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC22A17
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC22A17
    Cloud-Clone Corp. CLIAs for SLC22A17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Brain-type organic cation transporter
    Orphan or poorly characterized SLC22 family members

    4 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8WUG5

    ProtoNet protein and cluster: Q8WUG5

    UniProtKB/Swiss-Prot: S22AH_HUMAN, Q8WUG5
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    SLC22A17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22AH_HUMAN, Q8WUG5
    Function: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to
    bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby
    increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2
    (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore,
    leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron
    concentration and resulting in apoptosis (By similarity)
    Induction: Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression
    by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling
    pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ISS--
    GO:0005515protein binding ----
    GO:0022857transmembrane transporter activity IEA--
         
    SLC22A17 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC22A17
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC22A17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC22A17
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC22A17

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SLC22A17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC22A17 (see all 15):
    hsa-miR-4303 hsa-miR-1321 hsa-miR-3194-5p hsa-miR-15a hsa-miR-4297 hsa-miR-765 hsa-miR-497 hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A17 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC22A17
    Predesigned siRNA for gene silencing in human, mouse, rat SLC22A17

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC22A17

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC22A17 (see all 13)
    OriGene ORF clones in mouse, rat for SLC22A17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC22A17 (NM_020372)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A17

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC22A17
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC22A17 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    S22AH_HUMAN, Q8WUG5: Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
    Note=Upon LCN2-binding, it is internalized
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    vacuole5
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005774vacuolar membrane IEA--
    GO:0005887integral component of plasma membrane IDA17253959
    GO:0016021integral component of membrane ----
    GO:0031301integral component of organelle membrane IDA17253959

    SLC22A17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A17
    Interactions:

        GeneGlobe Interaction Network for SLC22A17

    1 Interacting protein for SLC22A17 (Q8WUG53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCN2P801883I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--
    GO:0007165signal transduction ISS--
    GO:0015891siderophore transport ISS--
    GO:0055085transmembrane transport ----

    SLC22A17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A17 (S22AH)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC22A17 gene (3 alternative transcripts): 
    NM_001289050.1  NM_016609.4  NM_020372.3  

    Unigene Cluster for SLC22A17:

    Solute carrier family 22, member 17
    Hs.373498  [show with all ESTs]
    Unigene Representative Sequence: BX161416
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354772(uc001wjm.3) ENST00000397260 ENST00000474057(uc001wjn.3)
    ENST00000206544(uc001wjl.3 uc010akk.3) ENST00000473917 ENST00000474774
    ENST00000557699(uc010akl.1) ENST00000556803 ENST00000397267
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC22A17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC22A17 (see all 15):
    hsa-miR-4303 hsa-miR-1321 hsa-miR-3194-5p hsa-miR-15a hsa-miR-4297 hsa-miR-765 hsa-miR-497 hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A17 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC22A17
    Predesigned siRNA for gene silencing in human, mouse, rat SLC22A17
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC22A17 (see all 13)
    OriGene ORF clones in mouse, rat for SLC22A17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC22A17 (NM_020372)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A17
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC22A17
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC22A17
      QuantiTect SYBR Green Assays in human, mouse, rat SLC22A17
      QuantiFast Probe-based Assays in human, mouse, rat SLC22A17

    Additional mRNA sequence: 

    AJ243653.1 AK308661.1 AK311241.1 BC020565.1 BC030559.1 BC090870.1 BC111015.1 BX161416.1 
    BX647316.1 DQ658848.1 

    14 DOTS entries:

    DT.91730294  DT.445029  DT.100788029  DT.95329077  DT.100778882  DT.100809449  DT.97845195  DT.100756795 
    DT.100676553  DT.95329079  DT.100650402  DT.100778885  DT.86854003  DT.75171847 

    Selected AceView cDNA sequences (see all 213):

    BX098469 BX346851 BX161416 BQ447129 H49989 BM688825 BF725228 BM729312 
    AI468081 CA394089 BU947245 BF525613 BM511408 AI754329 CA432174 NM_020372 
    AI445072 BU786039 BU728936 CR607061 AW297321 CK823850 BQ181972 AW191855 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A17 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12
    SP1:                                            -                                                                                 
    SP2:                                            -                                                           -                     
    SP3:                                                                                -                       -                     
    SP4:                    -                       -                                                                                 
    SP5:                                            -                                                                                 


    ECgene alternative splicing isoforms for SLC22A17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC22A17 expression in normal human tissues (normalized intensities)      SLC22A17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCTTCCT
    SLC22A17 Expression
    About this image


    SLC22A17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Lens
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
    SLC22A17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.373498

    UniProtKB/Swiss-Prot: S22AH_HUMAN, Q8WUG5
    Tissue specificity: Expressed in brain

        Custom PCR Arrays for SLC22A17
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC22A17
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC22A17
    QuantiTect SYBR Green Assays in human, mouse, rat SLC22A17
    QuantiFast Probe-based Assays in human, mouse, rat SLC22A17
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC22A17 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a171 , 5 solute carrier family 22 (organic cation transporter), more1, 5 91.58(n)1
    97.5(a)1
      14 (27.99 cM)5
    590491  NM_021551.41  NP_067526.21 
     549067275 
    lizard
    (Anolis carolinensis)
    Reptilia SLC22A176
    solute carrier family 22, member 17
    42(a)
    1 ↔ 1
    GL343680.1(226616-246714)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003299051 solute carrier family 22 member 17-like 53.88(n)
    45.77(a)
      100329905  XM_002666734.2  XP_002666780.2 


    ENSEMBL Gene Tree for SLC22A17 (if available)
    TreeFam Gene Tree for SLC22A17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC22A17 gene
    SLC22A232  SLC22A312  
    3 SIMAP similar genes for SLC22A17 using alignment to 2 protein entries:     S22AH_HUMAN (see all proteins):
    DKFZp434F011    SLC22A23    SLC22A31

    SLC22A17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC22A17 (see all 226)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860593191,2
    --23815052(+) ATCTAA/GAAGAA 2 -- int1 ds50010--------
    rs118444961,2
    C,F,H--23815109(+) TTCTCC/GGCTCC 2 -- int1 ds50019Minor allele frequency- G:0.04NS EA NA CSA WA 770
    rs1892602971,2
    --23815133(+) TACGAC/TGAGTT 2 -- int1 ds50010--------
    rs1158563281,2
    F--23815199(+) AATTCC/TCTTTT 2 -- int1 ds50011Minor allele frequency- T:0.01WA 118
    rs714250871,2
    C--23815261(+) AACAACAA/-CAACA 4 -- int1 cds1 ds50011Minor allele frequency- -:0.50NA 2
    rs1179715661,2
    C,F--23815326(+) TGATAC/TGAAGT 2 -- int1 ds50011Minor allele frequency- T:0.03NA 120
    rs1395247451,2
    C--23815335(+) GTGTGC/TCAAGT 2 -- int1 ds50010--------
    rs736024991,2
    C,F--23815374(+) GCAGTC/TAGTAA 2 -- int1 ds50012Minor allele frequency- T:0.04WA 120
    rs101301181,2
    C,F,A,H--23815409(+) CCACTC/GGGGGC 2 -- int1 ds500119Minor allele frequency- G:0.34NA NS EA WA CSA 929
    rs1492677691,2
    --23815447(+) GTTATC/TGGTGT 2 -- int1 ds50010--------

    HapMap Linkage Disequilibrium report for SLC22A17 (23815515 - 23822121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC22A17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901493CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A17
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611461    OMIM disorders: --

    7 diseases for SLC22A17:    About MalaCards
    esophageal squamous cell carcinoma    endometrial carcinoma    esophagitis    choroiditis
    squamous cell carcinoma    hepatocellular carcinoma    cerebritis


    SLC22A17 for disorders           About GeneDecksing


    Export disorders for SLC22A17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC22A17 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SLC22A17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. (PubMed id 16377569)1, 2, 3 Devireddy L.R.... Green M.R. (Cell 2005)
    2. A novel alternative spliced variant of neutrophil gelatinase- associated lipocalin receptor in oesophageal carcinoma cells. (PubMed id 17253959)1, 2 Fang W.K.... Li E.M. (Biochem. J. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. [Correlation of lipocalin-2 and its receptor expressions with preeclampsia]. (PubMed id 22932106)1 Cao W.H....Ye Y.H. (Zhonghua Fu Chan Ke Za Zhi 2012)
    5. NGAL and NGALR overexpression in human hepatocellular carcinoma toward a molecular prognostic classification. (PubMed id 22728279)1 Zhang Y....Mei Z. (Cancer Epidemiol 2012)
    6. Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma. (PubMed id 21763306)1 Miyamoto T....Shiozawa T. (Exp. Mol. Pathol. 2011)
    7. NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis. (PubMed id 21184133)1 Liu M.F....Xu H.X. (J. Neurooncol. 2011)
    8. Increased expression of neutrophil gelatinase-associated lipocalin receptor by interleukin-1I^ in human mesangial cells via MAPK/ERK activation. (PubMed id 21305251)1 Mao S....Zhang N. (Int. J. Mol. Med. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R. (PubMed id 19229297)2 Sheng Z.... Green M.R. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51310 HGNC: 23095 AceView: SLC22A17 Ensembl:ENSG00000092096 euGenes: HUgn51310
    ECgene: SLC22A17 H-InvDB: SLC22A17

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC22A17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC22A17 gene:
    Search GeneIP for patents involving SLC22A17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC22A17   OriGene RNAi products in human, mouse, rat for SLC22A17  
     OriGene qPCR primer pairs and template standards for SLC22A17   OriGene Protein Over-expression Lysate for SLC22A17  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC22A17  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC22A17   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC22A17   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC22A17   OriGene Custom Protein Services for SLC22A17  

     
     
     Block miRNA regulation of human, mouse, rat SLC22A17 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC22A17
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A17 Predesigned siRNA for gene silencing in human, mouse, rat SLC22A17
     QuantiFast Probe-based Assays in human, mouse, rat SLC22A17 QuantiTect SYBR Green Assays in human, mouse, rat SLC22A17
     Custom PCR Arrays for SLC22A17 Search Chromatin IP Primers for SLC22A17
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC22A17  GeneGlobe Interaction Network for SLC22A17
     Regulatory tfbs in SLC22A17 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC22A17 GenScript cDNA clones with any tag delivered in your preferred vector for SLC22A17
     GenScript Custom Assay Services for SLC22A17 GenScript Custom overexpressing Cell Line Services for SLC22A17
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC22A17 (S22AH)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC22A17 antibodies
     SLC22A17 proteins
     Antibodies for SLC22A17
     See all of Abcam's Antibodies, Kits and Proteins for SLC22A17
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SLC22A17
     Antibodies for SLC22A17
     ELISAs for SLC22A17
     CLIAs for SLC22A17



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC22A17
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A17
     SwitchGear 3'UTR luciferase reporter plasmids for SLC22A17
     SwitchGear Promoter luciferase reporter plasmids for SLC22A17
     ThermoFisher Antibodies for SLC22A17
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A17
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC22A17
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC22A17
     LSBio Antibodies in human, mouse, rat for SLC22A17
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC22A17 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4