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Aliases for SLC22A17 Gene

Aliases for SLC22A17 Gene

  • Solute Carrier Family 22 Member 17 2 3 5
  • Neutrophil Gelatinase-Associated Lipocalin Receptor 2 3 4
  • Brain-Type Organic Cation Transporter 3 4
  • Lipocalin-2 Receptor 3 4
  • 24p3 Receptor 3 4
  • NGALR 3 4
  • 24p3R 3 4
  • BOCT 3 4
  • BOIT 3 4
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 17 3
  • Potent Brain Type Organic Ion Transporter 3
  • Solute Carrier Family 22, Member 17 2
  • NGAL Receptor 3
  • NGALR2 3
  • NGALR3 3
  • HBOIT 3

External Ids for SLC22A17 Gene

Previous GeneCards Identifiers for SLC22A17 Gene

  • GC14M021805
  • GC14M022888
  • GC14M023815
  • GC14M003931

Summaries for SLC22A17 Gene

GeneCards Summary for SLC22A17 Gene

SLC22A17 (Solute Carrier Family 22 Member 17) is a Protein Coding gene. Among its related pathways are Insulin receptor recycling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transmembrane signaling receptor activity and transmembrane transporter activity. An important paralog of this gene is SLC22A23.

UniProtKB/Swiss-Prot for SLC22A17 Gene

  • Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A17 Gene

Genomics for SLC22A17 Gene

Regulatory Elements for SLC22A17 Gene

Enhancers for SLC22A17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F023145 1.6 FANTOM5 Ensembl ENCODE 9.9 +208.4 208425 2.8 PKNOX1 ATF1 ARNT YBX1 ZNF2 ELK1 GATA2 NCOA1 REST ZNF518A SLC7A8 RNF212B CEBPE ACIN1 SLC22A17 C14orf93 DHRS4 RNU6-1138P
GH14F023378 1.2 VISTA ENCODE 11.4 -25.1 -25064 3.2 ELF3 ZNF76 KLF17 ARID4B ZNF48 ZSCAN9 ZNF2 RAD21 RARA SLC30A9 MYH6 SLC22A17 MIR208B PPP1R3E HOMEZ BCL2L2 DHRS4-AS1 CMTM5 MIR208A
GH14F023140 1.3 FANTOM5 ENCODE 9.9 +212.9 212921 2.9 ZFP64 ARID4B DMAP1 ZNF48 ZNF121 SLC30A9 ZNF143 MXD4 ZHX2 MIER2 SLC7A8 RNF212B CEBPE ACIN1 SLC22A17 C14orf93 CMTM5 IL25 DHRS4-AS1 RNU6-1138P
GH14F023442 1.2 VISTA FANTOM5 ENCODE 10.7 -88.3 -88277 1.9 ZNF341 IKZF1 MYH6 MIR208B CMTM5 IL25 SLC22A17 MIR208A MYH7 NGDN
GH14F023237 1.2 Ensembl ENCODE 10.7 +117.0 117022 1.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 SP3 SP5 MXD4 KAT8 RNF212B SLC7A8 SLC22A17 BCL2L2 RPL39P2 RNU6-1046P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC22A17 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A17 Gene

Chromosome:
14
Start:
23,346,306 bp from pter
End:
23,354,976 bp from pter
Size:
8,671 bases
Orientation:
Minus strand

Genomic View for SLC22A17 Gene

Genes around SLC22A17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A17 Gene

Proteins for SLC22A17 Gene

  • Protein details for SLC22A17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUG5-S22AH_HUMAN
    Recommended name:
    Solute carrier family 22 member 17
    Protein Accession:
    Q8WUG5
    Secondary Accessions:
    • A4UA13
    • A8MUT0
    • Q2TAB0
    • Q5BKY8
    • Q86U04
    • Q9H1D3
    • Q9NQD5

    Protein attributes for SLC22A17 Gene

    Size:
    538 amino acids
    Molecular mass:
    57686 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAC01119.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC17762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A17 Gene

Post-translational modifications for SLC22A17 Gene

  • Glycosylation at Asn 23 and Asn 32
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC22A17 Gene

Domains & Families for SLC22A17 Gene

Gene Families for SLC22A17 Gene

Protein Domains for SLC22A17 Gene

Suggested Antigen Peptide Sequences for SLC22A17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUG5

UniProtKB/Swiss-Prot:

S22AH_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A17: view

Function for SLC22A17 Gene

Molecular function for SLC22A17 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway.

Gene Ontology (GO) - Molecular Function for SLC22A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity ISS --
GO:0005215 transporter activity IEA --
GO:0008514 organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC22A17: view
genes like me logo Genes that share phenotypes with SLC22A17: view

Animal Model Products

miRNA for SLC22A17 Gene

miRTarBase miRNAs that target SLC22A17

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A17 Gene

Localization for SLC22A17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A17 Gene

Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A17 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC22A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005773 vacuole IEA --
GO:0005774 vacuolar membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 17253959
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC22A17: view

Pathways & Interactions for SLC22A17 Gene

genes like me logo Genes that share pathways with SLC22A17: view

Pathways by source for SLC22A17 Gene

Interacting Proteins for SLC22A17 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000206544%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000206544 Q8WUG5-S22AH_HUMAN for SLC22A17 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC22A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0007165 signal transduction IEA --
GO:0015711 organic anion transport IEA --
genes like me logo Genes that share ontologies with SLC22A17: view

No data available for SIGNOR curated interactions for SLC22A17 Gene

Transcripts for SLC22A17 Gene

Unigene Clusters for SLC22A17 Gene

Solute carrier family 22, member 17:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -
SP7: -
SP8:

Relevant External Links for SLC22A17 Gene

GeneLoc Exon Structure for
SLC22A17
ECgene alternative splicing isoforms for
SLC22A17

Expression for SLC22A17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A17 Gene

This gene is overexpressed in Brain - Hypothalamus (x4.5).

Protein differential expression in normal tissues from HIPED for SLC22A17 Gene

This gene is overexpressed in Frontal cortex (59.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A17 Gene



Protein tissue co-expression partners for SLC22A17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC22A17 Gene:

SLC22A17

SOURCE GeneReport for Unigene cluster for SLC22A17 Gene:

Hs.373498

mRNA Expression by UniProt/SwissProt for SLC22A17 Gene:

Q8WUG5-S22AH_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expression patterns with SLC22A17: view

Primer Products

Orthologs for SLC22A17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A17 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia SLC22A17 34 35
  • 93.46 (n)
dog
(Canis familiaris)
Mammalia SLC22A17 34 35
  • 92.76 (n)
mouse
(Mus musculus)
Mammalia Slc22a17 34 16 35
  • 91.58 (n)
rat
(Rattus norvegicus)
Mammalia Slc22a17 34
  • 91.28 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC22A17 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SLC22A17 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100329905 34
  • 53.88 (n)
SLC22A17 (1 of 2) 35
  • 46 (a)
OneToMany
SLC22A17 (2 of 2) 35
  • 38 (a)
OneToMany
Species where no ortholog for SLC22A17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A17 Gene

ENSEMBL:
Gene Tree for SLC22A17 (if available)
TreeFam:
Gene Tree for SLC22A17 (if available)

Paralogs for SLC22A17 Gene

Paralogs for SLC22A17 Gene

(3) SIMAP similar genes for SLC22A17 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC22A17: view

Variants for SLC22A17 Gene

Sequence variations from dbSNP and Humsavar for SLC22A17 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10130118 -- 23,346,200(+) CCACT(C/G)GGGGC downstream-variant-500B
rs10142524 -- 23,354,822(+) GTGTT(C/G)TATCA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs10162489 -- 23,355,327(+) TTTAT(C/T)GTCTG upstream-variant-2KB
rs10162492 -- 23,355,510(+) CACAA(C/G)TACAT upstream-variant-2KB
rs111302845 -- 23,348,503(+) ATACT(C/G)ACCCA intron-variant

Variation tolerance for SLC22A17 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC22A17 Gene

Disorders for SLC22A17 Gene

Relevant External Links for SLC22A17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A17

No disorders were found for SLC22A17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A17 Gene

Publications for SLC22A17 Gene

  1. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. (PMID: 16377569) Devireddy L.R. … Green M.R. (Cell 2005) 2 3 4 64
  2. A novel alternative spliced variant of neutrophil gelatinase- associated lipocalin receptor in oesophageal carcinoma cells. (PMID: 17253959) Fang W.K. … Li E.M. (Biochem. J. 2007) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17. (PMID: 26635366) Cabedo Martinez A.I. … Coudevylle N. (J. Biol. Chem. 2016) 3 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for SLC22A17 Gene

Sources for SLC22A17 Gene

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