Aliases for SLC22A17 Gene
External Ids for SLC22A17 Gene
Previous GeneCards Identifiers for SLC22A17 Gene
GeneCards Summary for SLC22A17 Gene
SLC22A17 (Solute Carrier Family 22, Member 17) is a Protein Coding gene. GO annotations related to this gene include transmembrane signaling receptor activity and transmembrane transporter activity. An important paralog of this gene is SLC22A23.
UniProtKB/Swiss-Prot for SLC22A17 Gene
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).