Aliases for SLC22A17 Gene
External Ids for SLC22A17 Gene
Previous GeneCards Identifiers for SLC22A17 Gene
GeneCards Summary for SLC22A17 Gene
SLC22A17 (Solute Carrier Family 22 Member 17) is a Protein Coding gene. Among its related pathways are Insulin receptor recycling and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transmembrane signaling receptor activity and transmembrane transporter activity. An important paralog of this gene is SLC22A23.
UniProtKB/Swiss-Prot for SLC22A17 Gene
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).