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Aliases for SLC22A17 Gene

Aliases for SLC22A17 Gene

  • Solute Carrier Family 22, Member 17 2 3
  • Neutrophil Gelatinase-Associated Lipocalin Receptor 2 3 4
  • NGALR 3 4 6
  • BOCT 3 4 6
  • BOIT 3 4 6
  • Brain-Type Organic Cation Transporter 3 4
  • Lipocalin-2 Receptor 3 4
  • 24p3 Receptor 3 4
  • NGALR2 3 6
  • NGALR3 3 6
  • 24p3R 3 4
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 17 3
  • Potent Brain Type Organic Ion Transporter 3
  • Solute Carrier Family 22 Member 17 3
  • NGAL Receptor 3
  • HBOIT 3

External Ids for SLC22A17 Gene

Summaries for SLC22A17 Gene

GeneCards Summary for SLC22A17 Gene

SLC22A17 (Solute Carrier Family 22, Member 17) is a Protein Coding gene. GO annotations related to this gene include transmembrane signaling receptor activity and transmembrane transporter activity. An important paralog of this gene is SLC22A23.

UniProtKB/Swiss-Prot for SLC22A17 Gene

  • Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A17 Gene

Genomics for SLC22A17 Gene

Genomic Location for SLC22A17 Gene

Start:
23,346,306 bp from pter
End:
23,352,998 bp from pter
Size:
6,693 bases
Orientation:
Minus strand

Genomic View for SLC22A17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A17 Gene

Regulatory Elements for SLC22A17 Gene

Transcription factor binding sites by QIAGEN in the SLC22A17 gene promoter:

Proteins for SLC22A17 Gene

  • Protein details for SLC22A17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUG5-S22AH_HUMAN
    Recommended name:
    Solute carrier family 22 member 17
    Protein Accession:
    Q8WUG5
    Secondary Accessions:
    • A4UA13
    • A8MUT0
    • Q2TAB0
    • Q5BKY8
    • Q86U04
    • Q9H1D3
    • Q9NQD5

    Protein attributes for SLC22A17 Gene

    Size:
    538 amino acids
    Molecular mass:
    57686 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAC01119.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC17762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A17 Gene

Proteomics data for SLC22A17 Gene at MOPED

Post-translational modifications for SLC22A17 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn23 and Asn32

Other Protein References for SLC22A17 Gene

No data available for DME Specific Peptides for SLC22A17 Gene

Domains for SLC22A17 Gene

Gene Families for SLC22A17 Gene

Protein Domains for SLC22A17 Gene

UniProtKB/Swiss-Prot:

S22AH_HUMAN
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.:
    • Q8WUG5
genes like me logo Genes that share domains with SLC22A17: view

Function for SLC22A17 Gene

Molecular function for SLC22A17 Gene

UniProtKB/Swiss-Prot Function: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
UniProtKB/Swiss-Prot Induction: Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway.

Gene Ontology (GO) - Molecular Function for SLC22A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity ISS --
GO:0005515 protein binding --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A17: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC22A17 Gene

Localization for SLC22A17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A17 Gene

Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A17 Gene COMPARTMENTS Subcellular localization image for SLC22A17 gene
Compartment Confidence
plasma membrane 5
vacuole 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC22A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005773 vacuole --
GO:0005774 vacuolar membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 17253959
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC22A17: view

Pathways for SLC22A17 Gene

SuperPathways for SLC22A17 Gene

No Data Available

Interacting Proteins for SLC22A17 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000206544%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000206544 Q8WUG5-S22AH_HUMAN for SLC22A17 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC22A17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006879 cellular iron ion homeostasis TAS --
GO:0007165 signal transduction IEA --
GO:0015891 siderophore transport ISS --
GO:0055072 iron ion homeostasis --
genes like me logo Genes that share ontologies with SLC22A17: view

No data available for Pathways by source for SLC22A17 Gene

Transcripts for SLC22A17 Gene

Unigene Clusters for SLC22A17 Gene

Solute carrier family 22, member 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -
SP7: -
SP8:

Relevant External Links for SLC22A17 Gene

GeneLoc Exon Structure for
SLC22A17
ECgene alternative splicing isoforms for
SLC22A17

Expression for SLC22A17 Gene

mRNA expression in normal human tissues for SLC22A17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A17 Gene

This gene is overexpressed in Brain - Hypothalamus (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC22A17 Gene

SOURCE GeneReport for Unigene cluster for SLC22A17 Gene Hs.373498

mRNA Expression by UniProt/SwissProt for SLC22A17 Gene

Q8WUG5-S22AH_HUMAN
Tissue specificity: Expressed in brain
genes like me logo Genes that share expressions with SLC22A17: view

Orthologs for SLC22A17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A17 36
  • 99.74 (n)
  • 100 (a)
SLC22A17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A17 36
  • 93.46 (n)
  • 98.85 (a)
SLC22A17 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A17 36
  • 92.76 (n)
  • 98.08 (a)
SLC22A17 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a17 36
  • 91.58 (n)
  • 97.5 (a)
Slc22a17 16
Slc22a17 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A17 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 21 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc22a17 36
  • 91.28 (n)
  • 97.5 (a)
lizard
(Anolis carolinensis)
Reptilia SLC22A17 37
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100329905 36
  • 53.88 (n)
  • 45.77 (a)
SLC22A17 (1 of 2) 37
  • 46 (a)
OneToMany
SLC22A17 (2 of 2) 37
  • 38 (a)
OneToMany
Species with no ortholog for SLC22A17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A17 Gene

ENSEMBL:
Gene Tree for SLC22A17 (if available)
TreeFam:
Gene Tree for SLC22A17 (if available)

Paralogs for SLC22A17 Gene

Paralogs for SLC22A17 Gene

Selected SIMAP similar genes for SLC22A17 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC22A17: view

Variants for SLC22A17 Gene

Sequence variations from dbSNP and Humsavar for SLC22A17 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs910331 -- 23,348,372(+) AAATG(G/T)GCACC intron-variant
rs7142405 -- 23,354,905(+) TCCAC(A/G)TATGG upstream-variant-2KB
rs7144355 -- 23,354,953(+) ccagg(A/C)tggag upstream-variant-2KB
rs7148564 -- 23,354,704(+) tttta(A/T)ccaga upstream-variant-2KB
rs7160328 -- 23,349,221(+) TGCAG(C/G)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A17 Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Relevant External Links for SLC22A17 Gene

HapMap Linkage Disequilibrium report
SLC22A17

Disorders for SLC22A17 Gene

No disorders were found for SLC22A17 Gene.

No data available for UniProtKB/Swiss-Prot for SLC22A17 Gene

Publications for SLC22A17 Gene

  1. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. (PMID: 16377569) Devireddy L.R. … Green M.R. (Cell 2005) 2 3 4
  2. A novel alternative spliced variant of neutrophil gelatinase- associated lipocalin receptor in oesophageal carcinoma cells. (PMID: 17253959) Fang W.K. … Li E.M. (Biochem. J. 2007) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells. (PMID: 18064607) Miharada K. … Nakamura Y. (J. Cell. Physiol. 2008) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC22A17 Gene

Sources for SLC22A17 Gene

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