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SLC22A16 Gene

protein-coding   GIFtS: 52
GCID: GC06M110745

Solute Carrier Family 22 (Organic Cation/Carnitine Transporter),...

(Previous names: solute carrier family 22 (organic cation transporter), member...)
  Search for SLC22A16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22 (Organic Cation/Carnitine Transporter), Member
161 2
     OCT62 3
CT22 3 5     OAT62
FLIPT22 3 5     OKB12
Solute Carrier Family 22 (Organic Cation Transporter), Member 161 2     WUGSC:RG331P03.12
Carnitine Transporter 22 3     dJ261K5.12
Flipt 22 3     Fly-Like Putative Organic Ion Transporter 22
Fly-Like Putative Transporter 22 3     Organic Cation Transporter 62
Organic Cation Transporter OKB12 3     Solute Carrier Family 22 Member 162
Organic Cation/Carnitine Transporter 62 3     

External Ids:    HGNC: 203021   Entrez Gene: 854132   Ensembl: ENSG000000048097   OMIM: 6082765   UniProtKB: Q86VW13   

Export aliases for SLC22A16 gene to outside databases

Previous GC identifers: GC00U912987 GC06M110791 GC06M110852 GC06M108313


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A16 Gene:
This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The
encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful
treatment has been correlated with the level of activity of this transporter in tumor cells. (provided by RefSeq,
Dec 2011)

GeneCards Summary for SLC22A16 Gene:
SLC22A16 (solute carrier family 22 (organic cation/carnitine transporter), member 16) is a protein-coding gene. GO annotations related to this gene include organic cation transmembrane transporter activity and carnitine transmembrane transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22AG_HUMAN, Q86VW1
Function: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate
the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the
maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The
uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SLC22A16
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A16 promoter sequence
   Search Chromatin IP Primers for SLC22A16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1|6q21-q22.1   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

SLC22A16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M110745:  view genomic region     (about GC identifiers)

Start:
110,745,890 bp from pter      End:
110,797,844 bp from pter
Size:
51,955 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S22AG_HUMAN, Q86VW1 (See protein sequence)
Recommended Name: Solute carrier family 22 member 16  
Size: 577 amino acids; 64614 Da
Sequence caution: Sequence=BAB71419.1; Type=Erroneous initiation;
Secondary accessions: O14567 Q5JXM1 Q8IUG8 Q8IZD5 Q96M90 Q96RU0
Alternative splicing: 3 isoforms:  Q86VW1-1   Q86VW1-2   Q86VW1-3   

Explore the universe of human proteins at neXtProt for SLC22A16: NX_Q86VW1

Explore proteomics data for SLC22A16 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn65, Asn68, Asn108, Asn345, Asn352, Asn546, Asn558

  • See SLC22A16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149116.2  
    ENSEMBL proteins: 
     ENSP00000395642   ENSP00000357915   ENSP00000409306   ENSP00000416310   ENSP00000401007  
     ENSP00000328583   ENSP00000408799   ENSP00000402111  
    Reactome Protein details: Q86VW1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Carnitine transporter 2
    Organic zwitterions/cation transporters (OCTN)

    3 InterPro protein domains:
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q86VW1

    ProtoNet protein and cluster: Q86VW1

    UniProtKB/Swiss-Prot: S22AG_HUMAN, Q86VW1
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22AG_HUMAN, Q86VW1
    Function: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate
    the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the
    maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The
    uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005275amine transmembrane transporter activity IDA15963465
    GO:0015101organic cation transmembrane transporter activity IDA15963465
    GO:0015226carnitine transmembrane transporter activity IDA12089149
    GO:0022857transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC22A16           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC22A16:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC22A16
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22AG_HUMAN, Q86VW1: Membrane; Multi-pass membrane protein (Potential). Cell membrane. Note=Detected in the
    plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IDA12089149

    Find genes that share ontologies with SLC22A16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC22A16 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Organic cation transport0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43
    Doxorubicin Pathway, Pharmacokinetics0.43


    Find genes that share SuperPaths with SLC22A16           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC22A16
        Organic cation transport

    2 PharmGKB Pathways for SLC22A16
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A16
    Interactions:

        Search GeneGlobe Interaction Network for SLC22A16

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0007338single fertilization IMP12089149
    GO:0015695organic cation transport IDA12089149
    GO:0015837amine transport IDA15963465

    Find genes that share ontologies with SLC22A16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A16 (S22AG)

    2 HMDB Compounds for SLC22A16    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Carnitine(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate (see all 33)541-15-1--
    SodiumSodium (see all 2)7440-23-5--

    2 DrugBank Compounds for SLC22A16    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DoxorubicinAdria (see all 4)23214-92-8transportersubstrate20179710
    L-Carnitine(-)-Carnitine (see all 6)541-15-1transportersubstrate12089149

    3 PharmGKB related drug/compound annotations for SLC22A16 gene    About this table
    Drug/compound PharmGKB Annotation
    cyclophosphamideCA  
    doxorubicinCA  
    doxorubicinolCA  



    Find genes that share compounds with SLC22A16           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A16 gene: 
    NM_033125.3  

    Unigene Cluster for SLC22A16:

    Solute carrier family 22 (organic cation/carnitine transporter), member 16
    Hs.520319  [show with all ESTs]
    Unigene Representative Sequence: AB055798
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460159 ENST00000451557 ENST00000368919(uc003puf.3) ENST00000434949
    ENST00000437378 ENST00000424139 ENST00000461487(uc003pug.3) ENST00000330550(uc003pue.3)
    ENST00000439654 ENST00000456137
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    Additional mRNA sequence: 

    AB055798.1 AF268892.1 AK057306.1 AK304546.1 AY145502.1 BC012014.1 BC037247.1 BC047565.1 

    7 DOTS entries:

    DT.404773  DT.95160584  DT.100021981  DT.97835451  DT.91817866  DT.100758326  DT.40128838 

    Selected AceView cDNA sequences (see all 33):

    BC047565 AB055798 CD724071 BC012014 CD724114 AF268892 NM_033125 AA346824 
    BG213550 AW510962 AI632467 AA001259 BI827216 AY145502 AK057306 BX112646 
    BG772937 BI823444 AW341717 AA203115 BM560234 BG203585 BC037247 AA778598 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A16 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                            -           -                                   -         
    SP2:              -     -     -     -                       -                                   -         
    SP3:                                                        -                                             
    SP4:                          -     -           -     -     -                                             
    SP5:              -     -     -     -                                                                     


    ECgene alternative splicing isoforms for SLC22A16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC22A16 Expression
    About this image


    SLC22A16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             Mature Sertoli Cells Seminiferous Tubules
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebellum
    SLC22A16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520319

    UniProtKB/Swiss-Prot: S22AG_HUMAN, Q86VW1
    Tissue specificity: Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney.
    Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver.
    Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in
    ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during
    the normal secretory phase, but expression is significantly reduced in the proliferative phase

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A16 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a161 , 5 solute carrier family 22 (organic cation transporter), more1, 5 69.71(n)1
    56.39(a)1
      10 (21.99 cM)5
    708401  NM_027572.11  NP_081848.11 
     405703365 
    chicken
    (Gallus gallus)
    Aves SLC22A161 solute carrier family 22 (organic cation/carnitine more 67.86(n)
    60.47(a)
      421757  XM_419787.4  XP_419787.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC22A166
    solute carrier family 22 (organic cation/carnitine...
    58(a)
    1 ↔ 1
    1(191757812-191784001)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc22a161 solute carrier family 22 (organic cation/carnitine more 63.59(n)
    58.08(a)
      100488673  XM_002936935.2  XP_002936981.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-185l3.31 si:dkey-185l3.3 55.84(n)
    50.83(a)
      557279  NM_001025488.1  NP_001020659.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74586
    CG46306
    (see all 3)
    --
    27(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3L(21948210-21951141)
    2R(9103164-9106752)


    ENSEMBL Gene Tree for SLC22A16 (if available)
    TreeFam Gene Tree for SLC22A16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A16 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  
    SLC22A132  SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A32  SLC22A252  
    12 SIMAP similar genes for SLC22A16 using alignment to 6 protein entries:     S22AG_HUMAN (see all proteins):
    SLC22A25    SLC22A7    SLC22A10    SLC22A15    SLC22A4    SLC22A5
    SLC22A1    SLC22A13    SLC22A3    SLC22A6    SLC22A2    SLC22A12

    Find genes that share paralogs with SLC22A16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A16 (see all 1365)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881787921,2
    Cuntested1110763838(+) GTCCTA/C/GACCAA 2 V syn10--------
    rs69384311,2
    C,F,A,H--110745606(+) GGGGTG/TGCACT 1 -- int119Minor allele frequency- T:0.17NS EA NA CSA WA 2341
    rs113829431,2
    C--110745614(+) CTGGCG/-GGGAT 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1139098721,2
    C,F--110745693(+) GAGCCG/AAGATC 1 -- int12Minor allele frequency- A:0.08NA EA 122
    rs69383231,2
    C,A--110745730(+) CAGAGT/CGAGAC 1 -- int14Minor allele frequency- C:0.14NA WA CSA 7
    rs94874011,2
    C,F--110745737(+) AGACTC/TCATCT 1 -- int12Minor allele frequency- T:0.50NA WA 4
    rs38234471,2
    C,F,H--110745819(+) GTGGTG/AGGGAA 1 -- int19Minor allele frequency- A:0.06NS EA NA 1104
    rs38234481,2
    C,F--110745821(+) GGTGGG/AGAAAG 1 -- int12Minor allele frequency- A:0.13NA EA 240
    rs796872031,2
    C--110745846(+) ACATAG/AAAAAA 1 -- int14Minor allele frequency- A:0.10NA WA EA 360
    rs412885901,2
    C,F--110745971(+) TTATTA/TAAAAG 1 -- ut312Minor allele frequency- T:0.00NA 656

    HapMap Linkage Disequilibrium report for SLC22A16 (110745890 - 110797844 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC22A16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1560945CNV Insertion17803354
    nsv516397CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A16
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608276    OMIM disorders: --


    Find genes that share disorders with SLC22A16           About GenesLikeMe

    Genetic Association Database (GAD): SLC22A16
    Human Genome Epidemiology (HuGE) Navigator: SLC22A16 (5 documents)

    Export disorders for SLC22A16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A16 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SLC22A16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. (PubMed id 12089149)1, 2, 3, 7, 9 Enomoto A.... Endou H. (J. Biol. Chem. 2002)
    2. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. (PubMed id 20179710)1, 4, 7 Bray J....Boddy A.V. (Br. J. Cancer 2010)
    3. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PubMed id 12372408)1, 2, 3 Eraly S.A. and Nigam S.K. (Biochem. Biophys. Res. Commun. 2002)
    4. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. (PubMed id 17473959)1, 3, 9 Koepsell H....Volk C. (Pharm. Res. 2007)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer. (PubMed id 17581421)1, 2 Ota K.... Yaegashi N. (Int. J. Gynecol. Pathol. 2007)
    7. Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients. (PubMed id 17559346)1, 4 Lal S....Chowbay B. (Pharmacogenomics 2007)
    8. Expression of organic cation transporter SLC22A16 in human endometria. (PubMed id 17197897)1, 2 Sato N....Yaegashi N. (Int. J. Gynecol. Pathol. 2007)
    9. Characterization of the organic cation transporter SLC22A16: a doxorubicin importer. (PubMed id 15963465)1, 2 Okabe M.... Abe T. (Biochem. Biophys. Res. Commun. 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85413 HGNC: 20302 AceView: SLC22A16 Ensembl:ENSG00000004809 euGenes: HUgn85413
    ECgene: SLC22A16 H-InvDB: SLC22A16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A16 gene:
    Search GeneIP for patents involving SLC22A16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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