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Aliases for SLC22A16 Gene

Aliases for SLC22A16 Gene

  • Solute Carrier Family 22 (Organic Cation/Carnitine Transporter), Member 16 2 3
  • FLIPT2 3 4 6
  • CT2 3 4 6
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 16 2 3
  • Organic Cation/Carnitine Transporter 6 3 4
  • Fly-Like Putative Transporter 2 3 4
  • Organic Cation Transporter OKB1 3 4
  • Carnitine Transporter 2 3 4
  • Flipt 2 3 4
  • OCT6 3 4
  • Fly-Like Putative Organic Ion Transporter 2 3
  • Solute Carrier Family 22 Member 16 3
  • Organic Cation Transporter 6 3
  • WUGSC:RG331P03.1 3
  • DJ261K5.1 3
  • Oat6 3
  • OKB1 3

External Ids for SLC22A16 Gene

Previous GeneCards Identifiers for SLC22A16 Gene

  • GC00U912987
  • GC06M110791
  • GC06M110852
  • GC06M110745
  • GC06M108313

Summaries for SLC22A16 Gene

Entrez Gene Summary for SLC22A16 Gene

  • This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

GeneCards Summary for SLC22A16 Gene

SLC22A16 (Solute Carrier Family 22 (Organic Cation/Carnitine Transporter), Member 16) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include organic cation transmembrane transporter activity and carnitine transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A16 Gene

  • High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A16 Gene

Genomics for SLC22A16 Gene

Genomic Location for SLC22A16 Gene

Start:
110,424,687 bp from pter
End:
110,476,641 bp from pter
Size:
51,955 bases
Orientation:
Minus strand

Genomic View for SLC22A16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A16 Gene

No data available for Regulatory Elements for SLC22A16 Gene

Proteins for SLC22A16 Gene

  • Protein details for SLC22A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VW1-S22AG_HUMAN
    Recommended name:
    Solute carrier family 22 member 16
    Protein Accession:
    Q86VW1
    Secondary Accessions:
    • O14567
    • Q5JXM1
    • Q8IUG8
    • Q8IZD5
    • Q96M90
    • Q96RU0

    Protein attributes for SLC22A16 Gene

    Size:
    577 amino acids
    Molecular mass:
    64614 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71419.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A16 Gene

Proteomics data for SLC22A16 Gene at MOPED

Post-translational modifications for SLC22A16 Gene

  • Glycosylation at Asn57, Asn65, Asn68, Asn108, Asn345, Asn352, Asn546, and Asn558
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A16 Gene

No data available for DME Specific Peptides for SLC22A16 Gene

Domains for SLC22A16 Gene

Gene Families for SLC22A16 Gene

Protein Domains for SLC22A16 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86VW1

UniProtKB/Swiss-Prot:

S22AG_HUMAN :
  • Q86VW1
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A16: view

Function for SLC22A16 Gene

Molecular function for SLC22A16 Gene

UniProtKB/Swiss-Prot Function: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.

Gene Ontology (GO) - Molecular Function for SLC22A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005275 amine transmembrane transporter activity IDA 15963465
GO:0015101 organic cation transmembrane transporter activity IDA 15963465
GO:0015226 carnitine transmembrane transporter activity IDA 12089149
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC22A16: view

Phenotypes for SLC22A16 Gene

GenomeRNAi human phenotypes for SLC22A16:
genes like me logo Genes that share phenotypes with SLC22A16: view

miRNA for SLC22A16 Gene

miRTarBase miRNAs that target SLC22A16

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC22A16 Gene

Localization for SLC22A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A16 Gene

Membrane; Multi-pass membrane protein. Cell membrane. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A16 Gene COMPARTMENTS Subcellular localization image for SLC22A16 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC22A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 12089149
genes like me logo Genes that share ontologies with SLC22A16: view

Pathways for SLC22A16 Gene

genes like me logo Genes that share pathways with SLC22A16: view

Interacting Proteins for SLC22A16 Gene

Gene Ontology (GO) - Biological Process for SLC22A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007338 single fertilization IMP 12089149
GO:0015695 organic cation transport IDA 12089149
GO:0015837 amine transport IDA 15963465
genes like me logo Genes that share ontologies with SLC22A16: view

Compounds for SLC22A16 Gene

(2) HMDB Compounds for SLC22A16 Gene

Compound Synonyms Cas Number PubMed IDs
L-Carnitine
  • (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate
541-15-1
Sodium
  • Sodium
7440-23-5

(2) Drugbank Compounds for SLC22A16 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Doxorubicin
  • Adria
23214-92-8 transporter substrate
L-Carnitine
  • (-)-Carnitine
541-15-1 transporter substrate

(3) PharmGKB related drug/compound annotations for SLC22A16 Gene

Drug/compound Annotation
cyclophosphamide CA
doxorubicin CA
doxorubicinol CA
genes like me logo Genes that share compounds with SLC22A16: view

Transcripts for SLC22A16 Gene

Unigene Clusters for SLC22A16 Gene

Solute carrier family 22 (organic cation/carnitine transporter), member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - -

Relevant External Links for SLC22A16 Gene

GeneLoc Exon Structure for
SLC22A16
ECgene alternative splicing isoforms for
SLC22A16

Expression for SLC22A16 Gene

mRNA expression in normal human tissues for SLC22A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A16 Gene

This gene is overexpressed in Testis (30.1) and Whole Blood (9.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC22A16 Gene

SOURCE GeneReport for Unigene cluster for SLC22A16 Gene Hs.520319

mRNA Expression by UniProt/SwissProt for SLC22A16 Gene

Q86VW1-S22AG_HUMAN
Tissue specificity: Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.
genes like me logo Genes that share expressions with SLC22A16: view

Orthologs for SLC22A16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A16 35
  • 98.9 (n)
  • 98.96 (a)
SLC22A16 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A16 35
  • 77.51 (n)
  • 66.61 (a)
SLC22A16 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A16 35
  • 80.86 (n)
  • 69.41 (a)
SLC22A16 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a16 35
  • 69.71 (n)
  • 56.39 (a)
Slc22a16 16
Slc22a16 36
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A16 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A16 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682934 35
  • 72.37 (n)
  • 60.36 (a)
chicken
(Gallus gallus)
Aves SLC22A16 35
  • 67.86 (n)
  • 60.47 (a)
SLC22A16 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A16 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a16 35
  • 63.59 (n)
  • 58.08 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-185l3.3 35
  • 55.84 (n)
  • 50.83 (a)
SLC22A16 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4630 36
  • 26 (a)
ManyToMany
CG7442 36
  • 24 (a)
ManyToMany
CG7458 36
  • 27 (a)
ManyToMany
Species with no ortholog for SLC22A16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A16 Gene

ENSEMBL:
Gene Tree for SLC22A16 (if available)
TreeFam:
Gene Tree for SLC22A16 (if available)

Paralogs for SLC22A16 Gene

genes like me logo Genes that share paralogs with SLC22A16: view

Variants for SLC22A16 Gene

Sequence variations from dbSNP and Humsavar for SLC22A16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs221711 -- 110,442,024(-) aatgg(A/C)attaa intron-variant
rs221712 -- 110,441,623(-) ctctc(C/G)tcata intron-variant
rs221713 -- 110,440,139(-) accag(A/G)ttgcc intron-variant
rs221714 -- 110,439,569(-) ACATC(C/T)GTTTT intron-variant
rs221715 -- 110,437,002(-) GTTTG(G/T)GTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A16 Gene

Variant ID Type Subtype PubMed ID
nsv516397 CNV Gain 19592680
esv1560945 CNV Insertion 17803354

Relevant External Links for SLC22A16 Gene

HapMap Linkage Disequilibrium report
SLC22A16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A16 Gene

Disorders for SLC22A16 Gene

Relevant External Links for SLC22A16

Genetic Association Database (GAD)
SLC22A16
Human Genome Epidemiology (HuGE) Navigator
SLC22A16
genes like me logo Genes that share disorders with SLC22A16: view

No data available for UniProtKB/Swiss-Prot for SLC22A16 Gene

Publications for SLC22A16 Gene

  1. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. (PMID: 12089149) Enomoto A. … Endou H. (J. Biol. Chem. 2002) 2 3 4 23 25
  2. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. (PMID: 17473959) Koepsell H. … Volk C. (Pharm. Res. 2007) 2 3 23
  3. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PMID: 12372408) Eraly S.A. … Nigam S.K. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  4. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. (PMID: 20179710) Bray J. … Boddy A.V. (Br. J. Cancer 2010) 3 25 48
  5. Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias. (PMID: 12384147) Gong S. … Moscow J.A. (Exp. Hematol. 2002) 3 4

Products for SLC22A16 Gene

Sources for SLC22A16 Gene

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