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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC22A16 Gene

protein-coding   GIFtS: 50
GCID: GC06M110745

solute carrier family 22 (organic cation/carnitine transporter),...

(Previous names: solute carrier family 22 (organic cation transporter),...)
 Explore 9 diseases affiliated with
SLC22A16 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC22A16    

Aliases
for SLC22A16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 22 (Organic Cation/Carnitine Transporter), Member
161 2
     Organic Cation Transporter OKB12 3
CT21 2 3 5     Organic Cation/Carnitine Transporter 62 3
FLIPT21 2 3 5     OCT62 3
OAT61 2     WUGSC:RG331P03.12
OKB11 2     DJ261K5.11
Solute Carrier Family 22 (Organic Cation Transporter), Member 161 2     Fly-Like Putative Organic Ion Transporter 22
Carnitine Transporter 22 3     Organic Cation Transporter 62
Flipt 22 3     Solute Carrier Family 22 Member 162
Fly-Like Putative Transporter 22 3     

External Ids:    HGNC: 203021   Entrez Gene: 854132   Ensembl: ENSG000000048097   OMIM: 6082765   UniProtKB: Q86VW13   

Export aliases for SLC22A16 gene to outside databases

Previous GC identifers: GC00U912987 GC06M110791 GC06M110852 GC06M108313


Summaries
for SLC22A16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC22A16:
This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded
protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has
been correlated with the level of activity of this transporter in tumor cells. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: S22AG_HUMAN, Q86VW1
Function: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the
L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation
of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is
inhibited by various organic cations. The uptake of doxorubicin is sodium-independent




Genomic Views
for SLC22A16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLC22A16
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC22A16 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC22A16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1|6q21-q22.1   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

SLC22A16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M110745:  view genomic region     (about GC identifiers)

Start:
 110,745,890 bp from pter      End:
 110,797,844 bp from pter
Size:
 51,955 bases      Orientation:
 minus strand

Proteins
for SLC22A16 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S22AG_HUMAN, Q86VW1 (See protein sequence)
Recommended Name: Solute carrier family 22 member 16  
Size: 577 amino acids; 64614 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cell membrane. Note=Detected in the plasma
mebrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis
Sequence caution: Sequence=BAB71419.1; Type=Erroneous initiation;
Secondary accessions: O14567 Q5JXM1 Q8IUG8 Q8IZD5 Q96M90 Q96RU0
Alternative splicing: 3 isoforms:  Q86VW1-1   Q86VW1-2   Q86VW1-3   

Explore the universe of human proteins at neXtProt for SLC22A16: NX_Q86VW1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86VW1

    • SLC22A16 Protein expression data from MOPED and PaxDb:    About this image 
    SLC22A16 Protein Expression
    REFSEQ proteins: NP_149116.2  
    ENSEMBL proteins: 
     ENSP00000357915   ENSP00000395642   ENSP00000409306   ENSP00000416310   ENSP00000401007  
     ENSP00000328583   ENSP00000408799   ENSP00000402111  
    Reactome Protein details: Q86VW1
    Human Recombinant Protein Products for SLC22A16: 
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    Uscn Proteins for SLC22A16

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IDA12089149

    SLC22A16 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SLC22A16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC22A16 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q86VW1

    ProtoNet protein and cluster: Q86VW1

    UniProtKB/Swiss-Prot: S22AG_HUMAN, Q86VW1
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family


    Function
    for SLC22A16 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22AG_HUMAN, Q86VW1
    Function: High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the
    L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation
    of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is
    inhibited by various organic cations. The uptake of doxorubicin is sodium-independent

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005275amine transmembrane transporter activity IDA15963465
    GO:0015101organic cation transmembrane transporter activity IDA15963465
    GO:0015226carnitine transmembrane transporter activity IDA12089149
    GO:0022857transmembrane transporter activity ----
         
    SLC22A16 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC22A16:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for SLC22A16 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Organic cation/anion/zwitterion transport
    		Organic cation/anion/zwitterion transport1.00
    		Organic cation transport0.62
    3Doxorubicin Pathway, Pharmacokinetics
    		Doxorubicin Pathway, Pharmacokinetics1.00
    		Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SLC22A16
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Organic cation/anion/zwitterion transport
    Organic cation transport

    2 PharmGKB Pathways for SLC22A16
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics


    SLC22A16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC22A16

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0007338single fertilization IMP12089149
    GO:0015695organic cation transport IDA15963465
    GO:0015837amine transport IDA15963465

    SLC22A16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC22A16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC22A16 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC22A16

    2 HMDB Compounds for SLC22A16    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Carnitine(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate (see all 33)541-15-1--
    SodiumSodium (see all 2)7440-23-5--

    2 DrugBank Compounds for SLC22A16    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DoxorubicinDoxorubicin HCl (see all 5)23214-92-8transportersubstrate20179710
    L-Carnitine(-)-Carnitine (see all 6)541-15-1transportersubstrate12089149

    2 PharmGKB related drug/compound annotations for SLC22A16 gene    About this table
    Drug/compound PharmGKB Annotation
    doxorubicinCA  
    doxorubicinolCA  
    Search CenterWatch for drugs/clinical trials and news about SLC22A16 / S22AG 

    Transcripts
    for SLC22A16 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC22A16 gene: 
    NM_033125.3  

    Unigene Cluster for SLC22A16:

    Solute carrier family 22 (organic cation/carnitine transporter), member 16
    Hs.520319  [show with all ESTs]
    Unigene Representative Sequence: AB055798
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368919(uc003puf.3) ENST00000451557 ENST00000460159 ENST00000434949
    ENST00000437378 ENST00000424139 ENST00000461487(uc003pug.3) ENST00000330550(uc003pue.3)
    ENST00000439654 ENST00000456137

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB055798.1 AF268892.1 AK057306.1 AK304546.1 AY145502.1 BC012014.1 BC037247.1 BC047565.1 

    7 DOTS entries:

    DT.404773  DT.95160584  DT.100021981  DT.97835451  DT.91817866  DT.100758326  DT.40128838 

    24/33 AceView cDNA sequences (see all 33):

    AB055798 BC012014 CD724071 NM_033125 CD724114 AF268892 BC047565 BC037247 
    AY145502 AK057306 BX112646 BI827216 AA001259 BG772937 AW510962 AW341717 
    AI632467 AA203115 BI823444 BG203585 AA346824 BM560234 BG213550 AA778598 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A16 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                            -           -                                   -         
    SP2:              -     -     -     -                       -                                   -         
    SP3:                                                        -                                             
    SP4:                          -     -           -     -     -                                             
    SP5:              -     -     -     -                                                                     


    ECgene alternative splicing isoforms for SLC22A16

    Expression
    for SLC22A16 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC22A16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SLC22A16 Expression
    About this image

    SLC22A16 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesMature Sertoli CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC22A16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC22A16

    SOURCE GeneReport for Unigene cluster: Hs.520319

    UniProtKB/Swiss-Prot: S22AG_HUMAN, Q86VW1
    Tissue specificity: Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed
    in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in
    hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer
    clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory
    phase, but expression is significantly reduced in the proliferative phase

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    In Situ
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    Orthologs
    for SLC22A16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC22A16 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC22A161 solute carrier family 22 (organic cation/carnitine more 67.86(n)
    60.47(a)    		   421757  XM_419787.3  XP_419787.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC22A166
    		 --
    		 59(a)
    		 1 ↔ 1
    		 1(191758595-191768029)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-185l3.31 si:dkey-185l3.3 55.14(n)
    50.09(a)    		   557279  NM_001025488.1  NP_001020659.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG86546
    CG37906
    (see all 20)    		 --
    		 27(a)
    25(a)
    (see all 20)    		 1 ↔ 1
    possible ortholog
    (see all 20)    		 2R(15866749-15872255)
    2R(8760292-8762517)
    worm
    (Caenorhabditis elegans)    		 Secernentea oct-16
    		 Organic cation transporter 1
    		 25(a)
    		 1 ↔ 1
    		 I(9888348-9892214)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons 4-Oct6
    AtOCT16
    (see all 6)    		 organic cation/carnitine transporter1
    (see all 6)    		 25(a)
    22(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 3(7225135-7228595)
    1(27538276-27540235)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 urate anion exchanger, putative, expressed
    (see all 5)    		 26(a)
    22(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 4(31952709-31956074)
    7(22426668-22428645)


    ENSEMBL Gene Tree for SLC22A16 (if available)
    TreeFam Gene Tree for SLC22A16 (if available) 

    Paralogs
    for SLC22A16 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC22A16 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A92  
    SLC22A102  SLC22A132  SLC22A62  SLC22A152  SLC22A72  SLC22A122  SLC22A32  SLC22A252  
    15 SIMAP similar genes for SLC22A16 using alignment to 6 protein entries:     S22AG_HUMAN (see all proteins):
    SLC22A25    SLC22A7    SLC22A10    SLC22A15    SLC22A4    SLC22A5
    SLC22A14    SLC22A1    SLC22A13    SLC22A3    SLC22A6    SLC22A2
    SLC22A12    SLC22A24    SLC22A20

    SLC22A16 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC22A16 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1152 NCBI SNPs in SLC22A16 are shown (see all 1152)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1881787921,2
    		Cother110763838(+) GTCCTA/C/GACCAA 3 V syn10--------
    rs69384311,2
    		C,F,A,H--110745606(+) GGGGTG/TGCACT 1 -- int119Minor allele frequency- T:0.17NS EA NA CSA WA 2341
    rs113829431,2
    		C--110745612(+) CTGGCG/-GGGAT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs591202151,2
    		C--110745615(+) TGGCGG/-GGATA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1139098721,2
    		C--110745693(+) GAGCCG/AAGATC 1 -- int12Minor allele frequency- A:0.08NA EA 122
    rs69383231,2
    		C,A--110745730(+) CAGAGT/CGAGAC 1 -- int14Minor allele frequency- C:0.14NA WA CSA 7
    rs94874011,2
    		C,F--110745737(+) AGACTC/TCATCT 1 -- int12Minor allele frequency- T:0.50NA WA 4
    rs38234471,2
    		C,F,H--110745819(+) GTGGTG/AGGGAA 1 -- int19Minor allele frequency- A:0.06NS EA NA 1104
    rs38234481,2
    		C,F--110745821(+) GGTGGG/AGAAAG 1 -- int12Minor allele frequency- A:0.13NA EA 240
    rs796872031,2
    		C--110745846(+) ACATAG/AAAAAA 1 -- int14Minor allele frequency- A:0.10NA WA EA 360

    HapMap Linkage Disequilibrium report for SLC22A16 (110745890 - 110797844 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC22A16: --

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    Disorders / Diseases
    for SLC22A16 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC22A16 for disorders           About GeneDecksing

    OMIM gene information: 608276    OMIM disorders: --

    9 diseases for SLC22A16:    About MalaCards
    clear cell adenocarcinoma    epithelial ovarian cancer    ovarian cancer    epididymitis
    t-cell leukemia    adenocarcinoma    breast cancer    leukemia
    esophagitis

    Human Genome Epidemiology (HuGE) Navigator: SLC22A16 (5 documents)

    Export disorders for SLC22A16 gene to outside databases

    Publications
    for SLC22A16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC22A16 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SLC22A16)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. (PubMed id 12089149)1, 2, 3, 7, 9 Enomoto A.... Endou H. (2002)
    2. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PubMed id 12372408)1, 2, 3 Eraly S.A. and Nigam S.K. (2002)
    3. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. (PubMed id 17473959)1, 3, 9 Koepsell H....Volk C. (2007)
    4. Influence of pharmacogenetics on response and toxicit y in breast cancer patients treated with doxorubicin and cyclophosphamide. (PubMed id 20179710)1, 7 Bray J....Boddy A.V. (2010)
    5. Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer. (PubMed id 17581421)1, 2 Ota K.... Yaegashi N. (2007)
    6. Expression of organic cation transporter SLC22A16 in human endometria. (PubMed id 17197897)1, 2 Sato N....Yaegashi N. (2007)
    7. Characterization of the organic cation transporter SLC22A16: a doxorubicin importer. (PubMed id 15963465)1, 2 Okabe M....Abe T. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias. (PubMed id 12384147)1, 2 Gong S.... Moscow J.A. (2002)
    10. The human carnitine transporter SLC22A16 mediates hig h affinity uptake of the anticancer polyamine analogue bleomycin-A5. (PubMed id 20037140)1, 9 Aouida M....Ramotar D. (2010)

    External Searches for SLC22A16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing SLC22A16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85413 HGNC: 20302 AceView: SLC22A16 Ensembl:ENSG00000004809 euGenes: HUgn85413
    ECgene: SLC22A16 H-InvDB: SLC22A16

    Other Databases showing SLC22A16 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC22A16 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC22A16 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC22A16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC22A16 gene:
    Search GeneIP for patents involving SLC22A16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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