Aliases for SLC22A16 Gene
- Solute Carrier Family 22 (Organic Cation/Carnitine Transporter), Member 16 2 3
- FLIPT2 3 4 6
- CT2 3 4 6
- Solute Carrier Family 22 (Organic Cation Transporter), Member 16 2 3
- Organic Cation/Carnitine Transporter 6 3 4
- Fly-Like Putative Transporter 2 3 4
- Organic Cation Transporter OKB1 3 4
- Carnitine Transporter 2 3 4
- Flipt 2 3 4
External Ids for SLC22A16 Gene
This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]
GeneCards Summary for SLC22A16 Gene
SLC22A16 (Solute Carrier Family 22 (Organic Cation/Carnitine Transporter), Member 16) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include organic cation transmembrane transporter activity and carnitine transmembrane transporter activity. An important paralog of this gene is SLC22A12.
UniProtKB/Swiss-Prot for SLC22A16 Gene
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.