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Aliases for SLC22A16 Gene

Aliases for SLC22A16 Gene

  • Solute Carrier Family 22 Member 16 2 3
  • Solute Carrier Family 22 (Organic Cation/Carnitine Transporter), Member 16 2 3 5
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 16 2 3
  • Organic Cation/Carnitine Transporter 6 3 4
  • Fly-Like Putative Transporter 2 3 4
  • Organic Cation Transporter OKB1 3 4
  • Carnitine Transporter 2 3 4
  • Flipt 2 3 4
  • FLIPT2 3 4
  • OCT6 3 4
  • CT2 3 4
  • Fly-Like Putative Organic Ion Transporter 2 3
  • Epididymis Secretory Protein Li 18 3
  • Organic Cation Transporter 6 3
  • WUGSC:RG331P03.1 3
  • DJ261K5.1 3
  • HEL-S-18 3
  • OAT6 3
  • OKB1 3

External Ids for SLC22A16 Gene

Previous GeneCards Identifiers for SLC22A16 Gene

  • GC00U912987
  • GC06M110791
  • GC06M110852
  • GC06M110745
  • GC06M108313

Summaries for SLC22A16 Gene

Entrez Gene Summary for SLC22A16 Gene

  • This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

GeneCards Summary for SLC22A16 Gene

SLC22A16 (Solute Carrier Family 22 Member 16) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Doxorubicin Pathway, Pharmacokinetics. GO annotations related to this gene include transmembrane transporter activity and amine transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A16 Gene

  • High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A16 Gene

Genomics for SLC22A16 Gene

Regulatory Elements for SLC22A16 Gene

Promoters for SLC22A16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC22A16 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A16 Gene

Chromosome:
6
Start:
110,424,685 bp from pter
End:
110,476,641 bp from pter
Size:
51,957 bases
Orientation:
Minus strand

Genomic View for SLC22A16 Gene

Genes around SLC22A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A16 Gene

Proteins for SLC22A16 Gene

  • Protein details for SLC22A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VW1-S22AG_HUMAN
    Recommended name:
    Solute carrier family 22 member 16
    Protein Accession:
    Q86VW1
    Secondary Accessions:
    • O14567
    • Q5JXM1
    • Q8IUG8
    • Q8IZD5
    • Q96M90
    • Q96RU0

    Protein attributes for SLC22A16 Gene

    Size:
    577 amino acids
    Molecular mass:
    64614 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71419.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A16 Gene

Proteomics data for SLC22A16 Gene at MOPED

Post-translational modifications for SLC22A16 Gene

  • Glycosylation at Asn 57, Asn 65, Asn 68, Asn 108, Asn 345, Asn 352, Asn 546, and Asn 558
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A16 Gene

Antibody Products

No data available for DME Specific Peptides for SLC22A16 Gene

Domains & Families for SLC22A16 Gene

Gene Families for SLC22A16 Gene

Protein Domains for SLC22A16 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VW1

UniProtKB/Swiss-Prot:

S22AG_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A16: view

Function for SLC22A16 Gene

Molecular function for SLC22A16 Gene

UniProtKB/Swiss-Prot Function:
High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.

Gene Ontology (GO) - Molecular Function for SLC22A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015226 carnitine transmembrane transporter activity IDA,TAS --
genes like me logo Genes that share ontologies with SLC22A16: view
genes like me logo Genes that share phenotypes with SLC22A16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A16

CRISPR Products

miRNA for SLC22A16 Gene

miRTarBase miRNAs that target SLC22A16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A16 Gene

Localization for SLC22A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A16 Gene

Membrane; Multi-pass membrane protein. Cell membrane. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A16 Gene COMPARTMENTS Subcellular localization image for SLC22A16 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for SLC22A16 Gene

Pathways & Interactions for SLC22A16 Gene

genes like me logo Genes that share pathways with SLC22A16: view

Interacting Proteins for SLC22A16 Gene

Gene Ontology (GO) - Biological Process for SLC22A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0015695 organic cation transport IDA 12089149
GO:0015879 carnitine transport IDA 12089149
GO:0030154 cell differentiation IEA --
GO:0030317 sperm motility IMP 12089149
genes like me logo Genes that share ontologies with SLC22A16: view

No data available for SIGNOR curated interactions for SLC22A16 Gene

Drugs & Compounds for SLC22A16 Gene

(5) Drugs for SLC22A16 Gene - From: FDA Approved Drugs, DrugBank, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Transporter, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1582
L-Carnitine Approved Pharma Transporter, substrate 0
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2643
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1582
doxorubicinol Pharma 0

(1) Additional Compounds for SLC22A16 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC22A16: view

Transcripts for SLC22A16 Gene

Unigene Clusters for SLC22A16 Gene

Solute carrier family 22 (organic cation/carnitine transporter), member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - -

Relevant External Links for SLC22A16 Gene

GeneLoc Exon Structure for
SLC22A16
ECgene alternative splicing isoforms for
SLC22A16

Expression for SLC22A16 Gene

mRNA expression in normal human tissues for SLC22A16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A16 Gene

This gene is overexpressed in Testis (x30.1) and Whole Blood (x9.1).

Protein differential expression in normal tissues from HIPED for SLC22A16 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A16 Gene



SOURCE GeneReport for Unigene cluster for SLC22A16 Gene Hs.520319

mRNA Expression by UniProt/SwissProt for SLC22A16 Gene

Q86VW1-S22AG_HUMAN
Tissue specificity: Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase.
genes like me logo Genes that share expression patterns with SLC22A16: view

Protein tissue co-expression partners for SLC22A16 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC22A16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A16 35
  • 98.9 (n)
  • 98.96 (a)
SLC22A16 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A16 36
  • 67 (a)
OneToOne
SLC22A16 35
  • 77.51 (n)
  • 66.61 (a)
dog
(Canis familiaris)
Mammalia SLC22A16 35
  • 80.86 (n)
  • 69.41 (a)
SLC22A16 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a16 16
Slc22a16 35
  • 69.71 (n)
  • 56.39 (a)
Slc22a16 36
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A16 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A16 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682934 35
  • 72.37 (n)
  • 60.36 (a)
chicken
(Gallus gallus)
Aves SLC22A16 35
  • 67.86 (n)
  • 60.47 (a)
SLC22A16 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A16 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a16 35
  • 63.59 (n)
  • 58.08 (a)
zebrafish
(Danio rerio)
Actinopterygii SLC22A16 36
  • 48 (a)
OneToOne
si:dkey-185l3.3 35
  • 55.84 (n)
  • 50.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4630 36
  • 26 (a)
ManyToMany
CG7442 36
  • 24 (a)
ManyToMany
CG7458 36
  • 27 (a)
ManyToMany
Species with no ortholog for SLC22A16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A16 Gene

ENSEMBL:
Gene Tree for SLC22A16 (if available)
TreeFam:
Gene Tree for SLC22A16 (if available)

Paralogs for SLC22A16 Gene

genes like me logo Genes that share paralogs with SLC22A16: view

Variants for SLC22A16 Gene

Sequence variations from dbSNP and Humsavar for SLC22A16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs714368 - 110,456,925(-) CCCTC(A/G)TCATG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs723685 - 110,442,672(-) TGCAG(C/T)TGGAA reference, missense
rs12210538 - 110,438,805(+) TGTCC(A/G)TGGCG intron-variant, reference, missense
rs35948062 - 110,438,740(-) GTGGT(A/G)TCGTT intron-variant, reference, missense
rs221711 -- 110,442,024(-) aatgg(A/C)attaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A16 Gene

Variant ID Type Subtype PubMed ID
nsv516397 CNV Gain 19592680
esv1560945 CNV Insertion 17803354

Variation tolerance for SLC22A16 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.89; 74.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A16 Gene

HapMap Linkage Disequilibrium report
SLC22A16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A16 Gene

Disorders for SLC22A16 Gene

Relevant External Links for SLC22A16

Genetic Association Database (GAD)
SLC22A16
Human Genome Epidemiology (HuGE) Navigator
SLC22A16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A16

No disorders were found for SLC22A16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A16 Gene

Publications for SLC22A16 Gene

  1. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. (PMID: 12089149) Enomoto A. … Endou H. (J. Biol. Chem. 2002) 2 3 4 23 25 26 67
  2. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. (PMID: 20179710) Bray J. … Boddy A.V. (Br. J. Cancer 2010) 3 25 26
  3. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. (PMID: 17473959) Koepsell H. … Volk C. (Pharm. Res. 2007) 2 3 23
  4. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. (PMID: 20037140) Aouida M. … Ramotar D. (J. Biol. Chem. 2010) 3 23
  5. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PMID: 12372408) Eraly S.A. … Nigam S.K. (Biochem. Biophys. Res. Commun. 2002) 2 3

Products for SLC22A16 Gene

Sources for SLC22A16 Gene

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