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Aliases for SLC22A15 Gene

Aliases for SLC22A15 Gene

  • Solute Carrier Family 22, Member 15 2 3
  • FLIPT1 3 4 6
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 15 2 3
  • Fly-Like Putative Transporter 1 3 4
  • Flipt 1 3 4
  • Fly-Like Putative Organic Ion Transporter 1 3
  • Solute Carrier Family 22 Member 15 3
  • Trans-Like Protein 3
  • PRO34686 3

External Ids for SLC22A15 Gene

Previous GeneCards Identifiers for SLC22A15 Gene

  • GC01P115666
  • GC01P115865
  • GC01P116231
  • GC01P116520
  • GC01P114392

Summaries for SLC22A15 Gene

Entrez Gene Summary for SLC22A15 Gene

  • Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC22A15 Gene

SLC22A15 (Solute Carrier Family 22, Member 15) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A15 Gene

  • Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A15 Gene

Genomics for SLC22A15 Gene

Regulatory Elements for SLC22A15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC22A15 Gene

Start:
115,976,498 bp from pter
End:
116,070,054 bp from pter
Size:
93,557 bases
Orientation:
Plus strand

Genomic View for SLC22A15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A15 Gene

Proteins for SLC22A15 Gene

  • Protein details for SLC22A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD6-S22AF_HUMAN
    Recommended name:
    Solute carrier family 22 member 15
    Protein Accession:
    Q8IZD6
    Secondary Accessions:
    • A8MUR3
    • Q6UXP5
    • Q8TAL9
    • Q9NSH5

    Protein attributes for SLC22A15 Gene

    Size:
    547 amino acids
    Molecular mass:
    60540 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26358.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH26358.1; Type=Frameshift; Positions=7; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A15 Gene

Proteomics data for SLC22A15 Gene at MOPED

Post-translational modifications for SLC22A15 Gene

  • Glycosylation at Asn58, Asn63, Asn80, and Asn106
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A15 Gene

Domains for SLC22A15 Gene

Gene Families for SLC22A15 Gene

Protein Domains for SLC22A15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC22A15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZD6

UniProtKB/Swiss-Prot:

S22AF_HUMAN :
  • Q8IZD6
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A15: view

Function for SLC22A15 Gene

Molecular function for SLC22A15 Gene

UniProtKB/Swiss-Prot Function: Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.

Gene Ontology (GO) - Molecular Function for SLC22A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A15: view

Phenotypes for SLC22A15 Gene

GenomeRNAi human phenotypes for SLC22A15:
genes like me logo Genes that share phenotypes with SLC22A15: view

Animal Model Products

CRISPR Products

miRNA for SLC22A15 Gene

miRTarBase miRNAs that target SLC22A15

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC22A15 Gene

Localization for SLC22A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A15 Gene COMPARTMENTS Subcellular localization image for SLC22A15 gene
Compartment Confidence
plasma membrane 3
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC22A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A15: view

Pathways for SLC22A15 Gene

genes like me logo Genes that share pathways with SLC22A15: view

Interacting Proteins for SLC22A15 Gene

Gene Ontology (GO) - Biological Process for SLC22A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A15: view

Compounds for SLC22A15 Gene

(1) HMDB Compounds for SLC22A15 Gene

Compound Synonyms Cas Number PubMed IDs
Agmatine
  • (4-Aminobutyl)guanidine
306-60-5
genes like me logo Genes that share compounds with SLC22A15: view

Transcripts for SLC22A15 Gene

Unigene Clusters for SLC22A15 Gene

Solute carrier family 22, member 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A15

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -

Relevant External Links for SLC22A15 Gene

GeneLoc Exon Structure for
SLC22A15
ECgene alternative splicing isoforms for
SLC22A15

Expression for SLC22A15 Gene

mRNA expression in normal human tissues for SLC22A15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SLC22A15 Gene Hs.125482

mRNA Expression by UniProt/SwissProt for SLC22A15 Gene

Q8IZD6-S22AF_HUMAN
Tissue specificity: Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.
genes like me logo Genes that share expressions with SLC22A15: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein expression for SLC22A15 Gene

Orthologs for SLC22A15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A15 35
  • 99.63 (n)
  • 99.82 (a)
SLC22A15 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A15 35
  • 90.01 (n)
  • 94.52 (a)
SLC22A15 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A15 35
  • 88.29 (n)
  • 91.78 (a)
SLC22A15 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a15 35
  • 87.99 (n)
  • 94.12 (a)
Slc22a15 16
Slc22a15 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC22A15 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A15 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a15 35
  • 87.32 (n)
  • 95.06 (a)
chicken
(Gallus gallus)
Aves SLC22A15 35
  • 79.43 (n)
  • 86.63 (a)
SLC22A15 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A15 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53252 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a15.1 35
  • 62.92 (n)
  • 62.99 (a)
Str.16656 35
zebrafish
(Danio rerio)
Actinopterygii SLC22A15 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3790 36
  • 24 (a)
OneToMany
CG6126 36
  • 27 (a)
OneToMany
CG9317 36
  • 20 (a)
OneToMany
Orct 36
  • 31 (a)
OneToMany
Orct2 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F45E10.2 36
  • 22 (a)
OneToMany
oct-1 36
  • 24 (a)
OneToMany
Y82E9BR.16 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
Species with no ortholog for SLC22A15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC22A15 Gene

ENSEMBL:
Gene Tree for SLC22A15 (if available)
TreeFam:
Gene Tree for SLC22A15 (if available)

Paralogs for SLC22A15 Gene

Selected SIMAP similar genes for SLC22A15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC22A15: view

Variants for SLC22A15 Gene

Sequence variations from dbSNP and Humsavar for SLC22A15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs911225 -- 116,060,034(+) TTCTC(A/G)ACCAT intron-variant
rs924276 -- 115,978,468(-) ACCTG(A/G)TCCTT intron-variant
rs924277 -- 115,978,436(-) AATCA(G/T)CCAAG intron-variant
rs1045757 -- 116,069,084(-) GCCAG(A/G)GGCAA utr-variant-3-prime, nc-transcript-variant
rs1045759 -- 116,069,277(+) TTACT(G/T)TTTTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A15 Gene

Variant ID Type Subtype PubMed ID
esv27976 CNV Loss 19812545
nsv2522 CNV Insertion 18451855
nsv528884 CNV Loss 19592680
nsv831126 CNV Gain 17160897

Relevant External Links for SLC22A15 Gene

HapMap Linkage Disequilibrium report
SLC22A15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A15 Gene

Disorders for SLC22A15 Gene

Relevant External Links for SLC22A15

Genetic Association Database (GAD)
SLC22A15
Human Genome Epidemiology (HuGE) Navigator
SLC22A15
genes like me logo Genes that share disorders with SLC22A15: view

No data available for UniProtKB/Swiss-Prot for SLC22A15 Gene

Publications for SLC22A15 Gene

  1. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PMID: 12372408) Eraly S.A. … Nigam S.K. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines. (PMID: 15028572) Molderings G.J. … Gothert M. (Ann. N. Y. Acad. Sci. 2003) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SLC22A15 Gene

  • antibodies-online peptides for SLC22A15
  • antibodies-online antibodies for SLC22A15
  • antibodies-online kits for SLC22A15

Sources for SLC22A15 Gene

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