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Aliases for SLC22A15 Gene

Aliases for SLC22A15 Gene

  • Solute Carrier Family 22 Member 15 2 3 5
  • Solute Carrier Family 22 (Organic Cation Transporter), Member 15 2 3
  • Solute Carrier Family 22, Member 15 2 3
  • Fly-Like Putative Transporter 1 3 4
  • Flipt 1 3 4
  • FLIPT1 3 4
  • Fly-Like Putative Organic Ion Transporter 1 3
  • Trans-Like Protein 3
  • PRO34686 3

External Ids for SLC22A15 Gene

Previous GeneCards Identifiers for SLC22A15 Gene

  • GC01P115666
  • GC01P115865
  • GC01P116231
  • GC01P116520
  • GC01P114392

Summaries for SLC22A15 Gene

Entrez Gene Summary for SLC22A15 Gene

  • Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC22A15 Gene

SLC22A15 (Solute Carrier Family 22 Member 15) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A15 Gene

  • Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A15 Gene

Genomics for SLC22A15 Gene

Regulatory Elements for SLC22A15 Gene

Enhancers for SLC22A15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC22A15 on UCSC Golden Path with GeneCards custom track

Promoters for SLC22A15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC22A15 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A15 Gene

Chromosome:
1
Start:
115,976,498 bp from pter
End:
116,070,054 bp from pter
Size:
93,557 bases
Orientation:
Plus strand

Genomic View for SLC22A15 Gene

Genes around SLC22A15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A15 Gene

Proteins for SLC22A15 Gene

  • Protein details for SLC22A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD6-S22AF_HUMAN
    Recommended name:
    Solute carrier family 22 member 15
    Protein Accession:
    Q8IZD6
    Secondary Accessions:
    • A8MUR3
    • Q6UXP5
    • Q8TAL9
    • Q9NSH5

    Protein attributes for SLC22A15 Gene

    Size:
    547 amino acids
    Molecular mass:
    60540 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26358.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH26358.1; Type=Frameshift; Positions=7; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A15 Gene

Proteomics data for SLC22A15 Gene at MOPED

Post-translational modifications for SLC22A15 Gene

  • Glycosylation at Asn 58, Asn 63, Asn 80, and Asn 106
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A15 Gene

Domains & Families for SLC22A15 Gene

Gene Families for SLC22A15 Gene

Protein Domains for SLC22A15 Gene

Suggested Antigen Peptide Sequences for SLC22A15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZD6

UniProtKB/Swiss-Prot:

S22AF_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A15: view

Function for SLC22A15 Gene

Molecular function for SLC22A15 Gene

UniProtKB/Swiss-Prot Function:
Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.
genes like me logo Genes that share phenotypes with SLC22A15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A15

CRISPR Products

miRNA for SLC22A15 Gene

miRTarBase miRNAs that target SLC22A15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A15 Gene

Localization for SLC22A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A15 Gene COMPARTMENTS Subcellular localization image for SLC22A15 gene
Compartment Confidence
plasma membrane 3
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SLC22A15 Gene

Pathways & Interactions for SLC22A15 Gene

genes like me logo Genes that share pathways with SLC22A15: view

Interacting Proteins for SLC22A15 Gene

Gene Ontology (GO) - Biological Process for SLC22A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A15: view

No data available for SIGNOR curated interactions for SLC22A15 Gene

Drugs & Compounds for SLC22A15 Gene

(1) Drugs for SLC22A15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
agmatine Experimental, Investigational Pharma Activator 0
genes like me logo Genes that share compounds with SLC22A15: view

Transcripts for SLC22A15 Gene

Unigene Clusters for SLC22A15 Gene

Solute carrier family 22, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -

Relevant External Links for SLC22A15 Gene

GeneLoc Exon Structure for
SLC22A15
ECgene alternative splicing isoforms for
SLC22A15

Expression for SLC22A15 Gene

mRNA expression in normal human tissues for SLC22A15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for SLC22A15 Gene Hs.125482

mRNA Expression by UniProt/SwissProt for SLC22A15 Gene

Q8IZD6-S22AF_HUMAN
Tissue specificity: Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.
genes like me logo Genes that share expression patterns with SLC22A15: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC22A15 Gene

Orthologs for SLC22A15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC22A15 35
  • 90.01 (n)
  • 94.52 (a)
SLC22A15 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A15 35
  • 88.29 (n)
  • 91.78 (a)
SLC22A15 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a15 35
  • 87.99 (n)
  • 94.12 (a)
Slc22a15 16
Slc22a15 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC22A15 35
  • 99.63 (n)
  • 99.82 (a)
SLC22A15 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc22a15 35
  • 87.32 (n)
  • 95.06 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC22A15 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A15 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC22A15 35
  • 79.43 (n)
  • 86.63 (a)
SLC22A15 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC22A15 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc22a15.1 35
  • 62.92 (n)
  • 62.99 (a)
Str.16656 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53252 35
zebrafish
(Danio rerio)
Actinopterygii SLC22A15 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3790 36
  • 24 (a)
OneToMany
CG6126 36
  • 27 (a)
OneToMany
CG9317 36
  • 20 (a)
OneToMany
Orct 36
  • 31 (a)
OneToMany
Orct2 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F45E10.2 36
  • 22 (a)
OneToMany
oct-1 36
  • 24 (a)
OneToMany
Y82E9BR.16 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
Species with no ortholog for SLC22A15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC22A15 Gene

ENSEMBL:
Gene Tree for SLC22A15 (if available)
TreeFam:
Gene Tree for SLC22A15 (if available)

Paralogs for SLC22A15 Gene

(7) SIMAP similar genes for SLC22A15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC22A15: view

Variants for SLC22A15 Gene

Sequence variations from dbSNP and Humsavar for SLC22A15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17852419 - 116,035,288(+) GATTC(A/C/T)ATCTT nc-transcript-variant, downstream-variant-500B, reference, missense
rs911225 -- 116,060,034(+) TTCTC(A/G)ACCAT intron-variant
rs1045757 -- 116,069,084(-) GCCAG(A/G)GGCAA nc-transcript-variant, utr-variant-3-prime
rs1045759 -- 116,069,277(+) TTACT(G/T)TTTTT nc-transcript-variant, utr-variant-3-prime
rs1045760 -- 116,069,295(+) ACTGC(C/T)TTTAT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC22A15 Gene

Variant ID Type Subtype PubMed ID
esv27976 CNV Loss 19812545
nsv2522 CNV Insertion 18451855
nsv528884 CNV Loss 19592680
nsv831126 CNV Gain 17160897

Variation tolerance for SLC22A15 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.68; 72.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC22A15 Gene

Disorders for SLC22A15 Gene

Relevant External Links for SLC22A15

Genetic Association Database (GAD)
SLC22A15
Human Genome Epidemiology (HuGE) Navigator
SLC22A15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A15

No disorders were found for SLC22A15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A15 Gene

Publications for SLC22A15 Gene

  1. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PMID: 12372408) Eraly S.A. … Nigam S.K. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for SLC22A15 Gene

Sources for SLC22A15 Gene

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