SLC22A14 Gene
protein-coding GIFtS: 47
GCID: GC03P038322
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solute carrier family 22, member 14(Previous names: organic cationic transporter-like 4, solute carrier family...)
(Previous symbol: ORCTL4)
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Aliases
for SLC22A14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 22, Member 141 2 | | Organic Cation Transporter-Like 42 3 | | ORCTL41 2 3 | | ORCTL-42 3 | | OCTL21 2 | | OCTL42 | | Organic Cationic Transporter-Like 41 2 | | Solute Carrier Family 22 Member 142 | | Solute Carrier Family 22 (Organic Cation Transporter), Member 141 2 | | |
Export aliases for SLC22A14 gene to outside databasesPrevious GC identifers: GC00U912986 GC03P038308 |
Summaries
for SLC22A14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC22A14:
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with anothermember of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which isthought to transport small molecules and since this protein is conserved among several species, it is suggested tohave a fundamental role in mammalian systems. (provided by RefSeq, Jul 2008)
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Genomic Views
for SLC22A14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC22A14 gene promoter:
p53 FOXD3 GATA-1 AREB6 c-Rel POU2F1 POU2F1a Meis-1a ATF6 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC22A14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p21.3SLC22A14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P038322: view genomic region
(about GC identifiers)
Start:
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38,323,785 bp from pter |
End:
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38,360,066 bp from pter |
Size:
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36,282 bases |
Orientation:
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plus strand |
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Proteins
for SLC22A14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S22AE_HUMAN, Q9Y267 (See
protein sequence)Recommended Name: Solute carrier family 22 member 14 Size: 594 amino acids; 66684 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A0AVS9 A1L4H6 B2RCX3 Q6DJT3Explore the universe of human proteins at neXtProt for SLC22A14: NX_Q9Y267
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y267
SLC22A14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004794.2
ENSEMBL proteins: ENSP00000442528 ENSP00000396283 ENSP00000395711 ENSP00000273173
Human Recombinant Protein Products for SLC22A14:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SLC22A14 for ontologies About GeneDecksing
SLC22A14 Antibody Products:
Assay Products for SLC22A14: |
Protein
Domains /
Families
for SLC22A14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC22A14 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y267ProtoNet protein and cluster: Q9Y267 UniProtKB/Swiss-Prot: S22AE_HUMAN, Q9Y267Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family |
Function
for SLC22A14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015101 | organic cation transmembrane transporter activity |
NAS | 10072596 | | GO:0022857 | transmembrane transporter activity |
-- | -- |
SLC22A14 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A14 |
|
Pathways & Interactions
for SLC22A14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC22A14
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
SLC22A14 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC22A14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC22A14
Search CenterWatch for drugs/clinical trials and news about SLC22A14 / S22AE
|
Transcripts
for SLC22A14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC22A14 gene: NM_004803.3 Unigene Cluster for SLC22A14: Solute carrier family 22, member 14 Hs.165559 [show with all ESTs]Unigene Representative Sequence: AK1304975 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000466887 ENST00000448498 ENST00000423219 ENST00000496724(uc003cia.2)
ENST00000273173(uc010hhc.1 uc003cib.2 uc011ayo.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC22A14 (NM_004803) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC22A14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A14 |
Additional cDNA sequence: AB011082.1 AK130497.1 AK315317.1 BC075070.2 BC075071.2 BC126482.1 BC130543.1 BC144079.1 1 DOTS entry: DT.70101992 10 AceView cDNA sequences: BX280190 BV183450 BC075071 BC075070 NM_004803 AK130497 AB011082 AA921815 BV189072 AI446196
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A14 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
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| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC22A14
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Expression
for SLC22A14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC22A14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTCCAGGC
About this image
See SLC22A14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC22A14
SOURCE GeneReport for Unigene cluster: Hs.165559
UniProtKB/Swiss-Prot: S22AE_HUMAN, Q9Y267Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for SLC22A14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC22A14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A14 |
Orthologs
for SLC22A14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC22A14 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for SLC22A14 (if available)
TreeFam Gene Tree for SLC22A14 (if available) |
Paralogs
for SLC22A14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SLC22A14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC22A14 (38323785 - 38360066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC22A14: --
Human Gene Mutation Database (HGMD): SLC22A14
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A14 |
|
Disorders
/ Diseases
for SLC22A14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC22A14 for disorders About GeneDecksing
OMIM gene information: 604048
OMIM disorders: --
1  disease for SLC22A14: About MalaCardsalopecia
Human Genome Epidemiology (HuGE) Navigator: SLC22A14 (2 documents)
Export disorders for SLC22A14 gene to outside databases
|
Publications
for SLC22A14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC22A14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC22A14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. (PubMed id 10072596)1, 2, 3, 9 Nishiwaki T.... Nakamura Y. (1998)
- Characterization of a 1200-kb genomic segment of chromosome 3p22- p21.3. (PubMed id 10231028)1, 2, 9 Daigo Y.... Nakamura Y. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1 Yokoyama K....Hosoya T. (2010)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. (PubMed id 10213508)1 Daigo Y....Nakamura Y. (1999)
- Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression. (PubMed id 16131712)9 Yamada H....Sugimura H. (2005)
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External Searches for SLC22A14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLC22A14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC22A14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC22A14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC22A14 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC22A14 gene:
Search GeneIP for patents involving SLC22A14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC22A14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC22A14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC22A14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A14 |
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 | | | SLC22A14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A14 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A14 |
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