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SLC22A14 Gene

protein-coding   GIFtS: 50
GCID: GC03P038322

Solute Carrier Family 22, Member 14

(Previous names: organic cationic transporter-like 4, solute carrier family...)
(Previous symbol: ORCTL4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22, Member 141 2     ORCTL-42 3
ORCTL41 2 3     OCTL22
Organic Cationic Transporter-Like 41 2     OCTL42
Solute Carrier Family 22 (Organic Cation Transporter), Member 141 2     Solute Carrier Family 22 Member 142
Organic Cation Transporter-Like 42 3     

External Ids:    HGNC: 84951   Entrez Gene: 93892   Ensembl: ENSG000001446717   OMIM: 6040485   UniProtKB: Q9Y2673   

Export aliases for SLC22A14 gene to outside databases

Previous GC identifers: GC00U912986 GC03P038308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A14 Gene:
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another
member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is
thought to transport small molecules and since this protein is conserved among several species, it is suggested
to have a fundamental role in mammalian systems. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC22A14 Gene:
SLC22A14 (solute carrier family 22, member 14) is a protein-coding gene. GO annotations related to this gene include organic cation transmembrane transporter activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A14 gene promoter:
         p53   FOXD3   GATA-1   AREB6   c-Rel   POU2F1   POU2F1a   Meis-1a   ATF6   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A14 promoter sequence
   Search Chromatin IP Primers for SLC22A14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21.3

SLC22A14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A14 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P038322:  view genomic region     (about GC identifiers)

Start:
38,323,785 bp from pter      End:
38,360,066 bp from pter
Size:
36,282 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S22AE_HUMAN, Q9Y267 (See protein sequence)
Recommended Name: Solute carrier family 22 member 14  
Size: 594 amino acids; 66684 Da
Secondary accessions: A0AVS9 A1L4H6 B2RCX3 Q6DJT3

Explore the universe of human proteins at neXtProt for SLC22A14: NX_Q9Y267

Explore proteomics data for SLC22A14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn99, Asn117, Asn125, Asn150
  • Modification sites at PhosphoSitePlus

  • See SLC22A14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004794.2  
    ENSEMBL proteins: 
     ENSP00000442528   ENSP00000396283   ENSP00000273173  

    SLC22A14 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SLC22A14

     
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    Search eBioscience for ELISAs for SLC22A14 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic cation transporter-like 4
    Orphan or poorly characterized SLC22 family members

    3 InterPro protein domains:
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9Y267

    ProtoNet protein and cluster: Q9Y267

    UniProtKB/Swiss-Prot: S22AE_HUMAN, Q9Y267
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015101organic cation transmembrane transporter activity NAS10072596
    GO:0022857transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC22A14           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC22A14
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC22A14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC22A14

    miRNA
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    miRTarBase miRNAs that target SLC22A14:
    hsa-mir-128-3p (MIRT022050)

    Block miRNA regulation of human, mouse, rat SLC22A14 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC22A14:
    hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC22A14
    Predesigned siRNA for gene silencing in human, mouse, rat SLC22A14

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A14

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22AE_HUMAN, Q9Y267: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane NAS10072596
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC22A14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A14
    Interactions:

        Search GeneGlobe Interaction Network for SLC22A14

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015695organic cation transport NAS10072596
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with SLC22A14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A14 (S22AE)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A14 gene: 
    NM_004803.3  

    Unigene Cluster for SLC22A14:

    Solute carrier family 22, member 14
    Hs.165559  [show with all ESTs]
    Unigene Representative Sequence: AK130497
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466887 ENST00000448498 ENST00000496724(uc003cia.2) ENST00000273173(uc010hhc.1 uc003cib.2 uc011ayo.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC22A14 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SLC22A14:
    hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidSLC22A14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC22A14
    Predesigned siRNA for gene silencing in human, mouse, rat SLC22A14
    Clone
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    GenScript: all cDNA clones in your preferred vector: SLC22A14 (NM_004803)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC22A14
      QuantiFast Probe-based Assays in human, mouse, rat SLC22A14

    Additional mRNA sequence: 

    AB011082.1 AK130497.1 AK315317.1 BC075070.2 BC075071.2 BC126482.1 BC130543.1 BC144079.1 

    1 DOTS entry:

    DT.70101992 

    10 AceView cDNA sequences:

    BX280190 AA921815 BC075071 AK130497 AB011082 NM_004803 BC075070 BV183450 
    BV189072 AI446196 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A14    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                          -                                             
    SP2:                                                                        


    ECgene alternative splicing isoforms for SLC22A14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTCCAGGC
    SLC22A14 Expression
    About this image


    SLC22A14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
    SLC22A14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.165559

    UniProtKB/Swiss-Prot: S22AE_HUMAN, Q9Y267
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for SLC22A14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC22A14 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a141 , 5 solute carrier family 22 (organic cation transporter), more1, 5 72.66(n)1
    60.9(a)1
      9 (71.33 cM)5
    3821131  NM_001037749.21  NP_001032838.11 
     1191694555 
    lizard
    (Anolis carolinensis)
    Reptilia SLC22A146
    solute carrier family 22, member 14
    20(a)
    1 ↔ 1
    AAWZ02038813(6-5003)
    zebrafish
    (Danio rerio)
    Actinopterygii SLC22A146
    solute carrier family 22, member 14
    30(a)
    1 ↔ 1
    24(20432232-20434293) ENSDARG00000091412
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55926
    CG167276
    (see all 16)
    --
    24(a)
    21(a)
    (see all 16)
    many → 1
    many → 1
    (see all 16)
    3L(5890738-5892495)
    3R(15439103-15441506)
    worm
    (Caenorhabditis elegans)
    Secernentea C06H5.66
    B0252.36
    (see all 7)
    Protein B0252.3, isoform b
    (see all 7)
    20(a)
    19(a)
    (see all 7)
    many → 1
    many → 1
    (see all 7)
    V(17879844-17888984) WBGene00007394
    II(6902870-6907757) WBGene00015088


    ENSEMBL Gene Tree for SLC22A14 (if available)
    TreeFam Gene Tree for SLC22A14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A14 gene
    4 SIMAP similar genes for SLC22A14 using alignment to 2 protein entries:     S22AE_HUMAN (see all proteins):
    SLC22A13    SLC22A8    SLC22A6    SLC22A7

    Find genes that share paralogs with SLC22A14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A14 (see all 511)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66509181,2
    C--38345484(+) ACCATA/CCTGGC 1 -- us2k10--------
    rs1128860021,2
    C,F--38345532(+) AAAAAG/ATTAGC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs98365411,2
    C,F,A--38345539(+) TAGCCA/GGGCGT 1 -- us2k13Minor allele frequency- G:0.40NA CSA 5
    rs66509191,2
    C,A--38345555(+) cgggcA/Gcctgt 1 -- us2k10--------
    rs1510025531,2
    C--38345631(+) GAGCCA/GAGATC 1 -- us2k10--------
    rs1408374261,2
    --38345853(+) TCTTCA/GCTCTC 1 -- us2k10--------
    rs802630171,2
    C--38345868(+) TTTCCG/ATGTTG 1 -- us2k14Minor allele frequency- A:0.08WA NA EA 360
    rs1176388661,2
    C,F--38345909(+) GGTCTT/CGCTCT 1 -- us2k11Minor allele frequency- C:0.12EA 120
    rs1459122641,2
    C--38345964(+) GCCTCA/GACCTC 1 -- us2k10--------
    rs1387247471,2
    C--38345980(+) CTCAGG/TTGATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC22A14 (38323785 - 38360066 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC22A14: --
    Human Gene Mutation Database (HGMD): SLC22A14
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A14
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604048    OMIM disorders: --


    Find genes that share disorders with SLC22A14           About GenesLikeMe

    Genetic Association Database (GAD): SLC22A14
    Human Genome Epidemiology (HuGE) Navigator: SLC22A14 (2 documents)

    Export disorders for SLC22A14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A14 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SLC22A14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. (PubMed id 10072596)1, 2, 3, 9 Nishiwaki T.... Nakamura Y. (Cytogenet. Cell Genet. 1998)
    2. Characterization of a 1200-kb genomic segment of chromosome 3p22- p21.3. (PubMed id 10231028)1, 2, 9 Daigo Y.... Nakamura Y. (DNA Res. 1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. (PubMed id 10213508)1 Daigo Y....Nakamura Y. (Cancer Res. 1999)
    10. Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression. (PubMed id 16131712)9 Yamada H....Sugimura H. (J. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9389 HGNC: 8495 AceView: SLC22A14 Ensembl:ENSG00000144671 euGenes: HUgn9389
    ECgene: SLC22A14 H-InvDB: SLC22A14

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A14 gene:
    Search GeneIP for patents involving SLC22A14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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