SLC22A13 Gene
protein-coding GIFtS: 44
GCID: GC03P038307
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solute carrier family 22 (organic anion transporter), member...(Previous name: organic cationic transporter-like 3 )
(Previous symbol: ORCTL3)
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Aliases
for SLC22A13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 22 (Organic Anion Transporter), Member 131 2 | | Organic Cation Transporter-Like 32 3 | | ORCTL31 2 3 | | ORCTL-32 3 | | OAT101 2 | | Organic-Cation Transporter Like 32 | | OCTL11 2 | | Solute Carrier Family 22 Member 132 | | OCTL31 2 | | Solute Carrier Family 22, Member 132 | | Organic Cationic Transporter-Like 31 2 | | |
Export aliases for SLC22A13 gene to outside databasesPrevious GC identifers: GC00U912985 GC03P038267 GC03P038282 |
Summaries
for SLC22A13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC22A13:
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with anothermember of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved inthe transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinateexchanger in the kidneys and the intestine. (provided by RefSeq, Sep 2008)
|
Genomic Views
for SLC22A13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC22A13 gene promoter:
USF1 AML1a USF-1 HNF-1 IRF-7A HNF-1A Evi-1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC22A13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p22.2SLC22A13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P038307: view genomic region
(about GC identifiers)
Start:
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38,307,298 bp from pter |
End:
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38,319,806 bp from pter |
Size:
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12,509 bases |
Orientation:
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plus strand |
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Proteins
for SLC22A13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S22AD_HUMAN, Q9Y226 (See
protein sequence)Recommended Name: Solute carrier family 22 member 13 Size: 551 amino acids; 60862 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RCV9 Q8IYG1Alternative splicing: 2 isoforms: Q9Y226-1 Q9Y226-2 Explore the universe of human proteins at neXtProt for SLC22A13: NX_Q9Y226
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y226
SLC22A13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004247.2
ENSEMBL proteins: ENSP00000310241 ENSP00000395106 ENSP00000406929
Human Recombinant Protein Products for SLC22A13:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SLC22A13 for ontologies About GeneDecksing
SLC22A13 Antibody Products:
Assay Products for SLC22A13: |
Protein
Domains /
Families
for SLC22A13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC22A13 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y226ProtoNet protein and cluster: Q9Y226 UniProtKB/Swiss-Prot: S22AD_HUMAN, Q9Y226Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family |
Function
for SLC22A13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015101 | organic cation transmembrane transporter activity |
NAS | 10072596 |
SLC22A13 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A13 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A13 |
|
Pathways & Interactions
for SLC22A13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC22A13
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
SLC22A13 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC22A13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC22A13
Search CenterWatch for drugs/clinical trials and news about SLC22A13 / S22AD
|
Transcripts
for SLC22A13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC22A13 gene: NM_004256.3 Unigene Cluster for SLC22A13: Solute carrier family 22 (organic anion transporter), member 13 Hs.225941 [show with all ESTs]Unigene Representative Sequence: NM_0042563 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311856(uc011aym.1 uc011ayn.1 uc003chz.3) ENST00000415844
ENST00000450935
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A13 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC22A13 (NM_004256) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC22A13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A13 |
Additional cDNA sequence: AB010438.1 AK315301.1 2 DOTS entries: DT.100000451 DT.75193280 11 AceView cDNA sequences: BI517655 BC035973 AB010438 NM_004256 AI934403 BE326882 BF589890 BF510842 BF476068 BG432776 BI518368
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A13 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC22A13
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Expression
for SLC22A13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC22A13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGGTGAGG
About this image
See SLC22A13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC22A13
SOURCE GeneReport for Unigene cluster: Hs.225941
UniProtKB/Swiss-Prot: S22AD_HUMAN, Q9Y226Tissue specificity: Ubiquitous, expressed at low levels
SABiosciences Custom PCR Arrays for SLC22A13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLC22A13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A13 |
Orthologs
for SLC22A13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC22A13 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for SLC22A13 (if available)
TreeFam Gene Tree for SLC22A13 (if available) |
Paralogs
for SLC22A13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC22A13 gene
- SLC22A112 SLC22A52 SLC22A82 SLC22A12 SLC22A242 SLC22A42 SLC22A92 SLC22A22
- SLC22A102 SLC22A62 SLC22A152 SLC22A72 SLC22A122 SLC22A32 SLC22A252 SLC22A162
18/20 SIMAP similar genes for SLC22A13 using alignment to 3 protein entries: S22AD_HUMAN (see all proteins)
(see all similar genes):SLC22A15 SLC22A8 SLC22A14 SLC22A6 HMFN2567 SLC22A12
SLC22A25 SLC22A7 SLC22A11 OAT7 SLC22A10 SLC22A20
SLC22A9 SLC22A2 SLC22A1 SLC22A24 SLC22A3 SLC22A4
SLC22A13 for paralogs About GeneDecksing
|
Genomic Variants
for SLC22A13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC22A13 (38307298 - 38319806 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC22A13: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A13 |
|
Disorders
/ Diseases
for SLC22A13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLC22A13 for disorders About MalaCards
SLC22A13 for disorders About GeneDecksing
OMIM gene information: 604047
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: SLC22A13 (2 documents)
Export disorders for SLC22A13 gene to outside databases
|
Publications
for SLC22A13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC22A13 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SLC22A13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. (PubMed id 10072596)1, 2, 3, 9 Nishiwaki T.... Nakamura Y. (1998)
- Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). (PubMed id 18411268)1, 3, 9 Bahn A....Burckhardt G. (2008)
- Characterization of a 1200-kb genomic segment of chromosome 3p22- p21.3. (PubMed id 10231028)1, 2, 9 Daigo Y.... Nakamura Y. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers. (PubMed id 19282870)1, 9 Irshad S....Grimm S. (2009)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The effects of genetic polymorphisms in the organic c ation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. (PubMed id 19536068)1 Tzvetkov M.V....BrockmAPller J. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC22A13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC22A13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC22A13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC22A13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC22A13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC22A13 gene:
Search GeneIP for patents involving SLC22A13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC22A13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC22A13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC22A13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A13 |
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 | | | SLC22A13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A13 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SLC22A13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A13 |
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