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Aliases for SLC22A13 Gene

Aliases for SLC22A13 Gene

  • Solute Carrier Family 22 Member 13 2 3 5
  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 13 2 3
  • Solute Carrier Family 22 (Organic Anion Transporter), Member 13 2 3
  • Organic Cationic Transporter-Like 3 2 3
  • ORCTL-3 3 4
  • ORCTL3 3 4
  • OCTL1 3 4
  • Organic-Cation Transporter Like 3 3
  • Organic Cation Transporter-Like 3 4
  • OAT10 3
  • OCTL3 3

External Ids for SLC22A13 Gene

Previous HGNC Symbols for SLC22A13 Gene

  • ORCTL3

Previous GeneCards Identifiers for SLC22A13 Gene

  • GC00U912985
  • GC03P038267
  • GC03P038282

Summaries for SLC22A13 Gene

Entrez Gene Summary for SLC22A13 Gene

  • This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]

GeneCards Summary for SLC22A13 Gene

SLC22A13 (Solute Carrier Family 22 Member 13) is a Protein Coding gene. Among its related pathways are NAD metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include transmembrane transporter activity and nicotinate transporter activity. An important paralog of this gene is SLC22A7.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A13 Gene

Genomics for SLC22A13 Gene

Regulatory Elements for SLC22A13 Gene

Enhancers for SLC22A13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G038163 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -98.6 -98609 8.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 OXSR1 ACAA1 MYD88 C3orf35 GORASP1 SLC22A13 ACVR2B-AS1 VILL PLCD1 DLEC1
GH03G038147 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -116.9 -116890 3.0 HDAC1 ZNF121 ZNF766 GATA2 IKZF2 CREM ZEB2 MEF2D MTA1 SMARCA4 SLC22A13 VILL MYD88 PLCD1 OXSR1
GH03G038327 0.9 ENCODE 10.7 +62.0 61958 0.2 HDAC1 PKNOX1 CBX3 ATF1 ZNF766 GATA2 FOS CEBPB ZEB2 ELF1 SLC22A14 SLC22A13 DLEC1P1 RNU6-235P GC03M038303
GH03G038102 0.8 FANTOM5 Ensembl 11.1 -163.4 -163355 0.9 IKZF1 ZNF341 KDM1A MYD88 VILL ACAA1 SLC22A13 PLCD1 OXSR1 SLC22A14 PIR60395 GC03M038048
GH03G038267 0.7 Ensembl ENCODE 0.7 +1.9 1890 0.7 L3MBTL2 MNT MGA RNU6-235P XYLB MYD88 ACAA1 VILL SLC22A13 GC03M038270
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC22A13 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A13 Gene

38,265,807 bp from pter
38,278,315 bp from pter
12,509 bases
Plus strand

Genomic View for SLC22A13 Gene

Genes around SLC22A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A13 Gene

Proteins for SLC22A13 Gene

  • Protein details for SLC22A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 22 member 13
    Protein Accession:
    Secondary Accessions:
    • B2RCV9
    • Q8IYG1

    Protein attributes for SLC22A13 Gene

    551 amino acids
    Molecular mass:
    60862 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A13 Gene


neXtProt entry for SLC22A13 Gene

Post-translational modifications for SLC22A13 Gene

  • Glycosylation at Asn57, isoforms=261, Asn92, and isoforms=2104
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A13 Gene

Domains & Families for SLC22A13 Gene

Gene Families for SLC22A13 Gene

Protein Domains for SLC22A13 Gene

Suggested Antigen Peptide Sequences for SLC22A13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A13: view

Function for SLC22A13 Gene

Gene Ontology (GO) - Molecular Function for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0015101 organic cation transmembrane transporter activity NAS 10072596
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
GO:0090416 nicotinate transporter activity IDA 18411268
genes like me logo Genes that share ontologies with SLC22A13: view
genes like me logo Genes that share phenotypes with SLC22A13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC22A13

CRISPR Products

miRNA for SLC22A13 Gene

miRTarBase miRNAs that target SLC22A13

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC22A13 Gene

Localization for SLC22A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A13 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10072596
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IDA 18411268
genes like me logo Genes that share ontologies with SLC22A13: view

Pathways & Interactions for SLC22A13 Gene

genes like me logo Genes that share pathways with SLC22A13: view

Pathways by source for SLC22A13 Gene

Interacting Proteins for SLC22A13 Gene

Selected Interacting proteins: Q9Y226-S22AD_HUMAN for SLC22A13 Gene via IID

Gene Ontology (GO) - Biological Process for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015695 organic cation transport NAS 10072596
GO:0015698 inorganic anion transport IEA --
GO:0015747 urate transport IDA 10072596
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS --
GO:0043252 sodium-independent organic anion transport IBA --
genes like me logo Genes that share ontologies with SLC22A13: view

No data available for SIGNOR curated interactions for SLC22A13 Gene

Drugs & Compounds for SLC22A13 Gene

No Compound Related Data Available

Transcripts for SLC22A13 Gene

mRNA/cDNA for SLC22A13 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A13 Gene

Solute carrier family 22 (organic anion transporter), member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: -

Relevant External Links for SLC22A13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC22A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A13 Gene

This gene is overexpressed in Kidney - Cortex (x17.6).

Protein differential expression in normal tissues from HIPED for SLC22A13 Gene

This gene is overexpressed in Urine (46.1) and Kidney (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC22A13 Gene

Protein tissue co-expression partners for SLC22A13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC22A13 Gene:


SOURCE GeneReport for Unigene cluster for SLC22A13 Gene:


mRNA Expression by UniProt/SwissProt for SLC22A13 Gene:

Tissue specificity: Ubiquitous, expressed at low levels.

Evidence on tissue expression from TISSUES for SLC22A13 Gene

  • Kidney(4.6)
genes like me logo Genes that share expression patterns with SLC22A13: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A13 Gene

Orthologs for SLC22A13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC22A13 34 35
  • 99.46 (n)
(Canis familiaris)
Mammalia SLC22A13 34 35
  • 83.18 (n)
(Mus musculus)
Mammalia Slc22a13 34 16 35
  • 79.13 (n)
Slc22a13b-ps 35
  • 74 (a)
(Rattus norvegicus)
Mammalia Slc22a13 34
  • 77.98 (n)
(Bos Taurus)
Mammalia SLC22A13 34 35
  • 77.82 (n)
(Monodelphis domestica)
Mammalia SLC22A13 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
-- 35
  • 53 (a)
(Gallus gallus)
Aves SLC22A13 34
  • 58.74 (n)
-- 35
  • 48 (a)
-- 35
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
-- 35
  • 46 (a)
(Danio rerio)
Actinopterygii zgc:153639 34
  • 53.74 (n)
SLC22A13 35
  • 48 (a)
Species where no ortholog for SLC22A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A13 Gene

Gene Tree for SLC22A13 (if available)
Gene Tree for SLC22A13 (if available)

Paralogs for SLC22A13 Gene

Variants for SLC22A13 Gene

Sequence variations from dbSNP and Humsavar for SLC22A13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000074773 -- 38,276,836(+) CTCCC(A/G)AGGAA intron-variant
rs1000285368 -- 38,263,878(+) GAGAC(C/T)GACTC upstream-variant-2KB
rs1000295155 -- 38,274,444(+) TCCCC(C/G)TTATG intron-variant
rs1000325737 -- 38,274,180(+) ATGAG(-/CTC)CTGCC intron-variant
rs1000338587 -- 38,264,319(+) GCTGG(A/G)GACAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC22A13 Gene

Variant ID Type Subtype PubMed ID
esv3595905 OTHER inversion 21293372
esv3595908 CNV loss 21293372
nsv3769 CNV insertion 18451855
nsv528237 CNV loss 19592680
nsv999852 CNV loss 25217958

Variation tolerance for SLC22A13 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A13 Gene

Disorders for SLC22A13 Gene

Relevant External Links for SLC22A13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC22A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A13 Gene

Publications for SLC22A13 Gene

  1. Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. (PMID: 10072596) Nishiwaki T. … Nakamura Y. (Cytogenet. Cell Genet. 1998) 2 3 4 22 64
  2. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). (PMID: 18411268) Bahn A. … Burckhardt G. (J. Biol. Chem. 2008) 2 3 22 64
  3. Characterization of a 1200-kb genomic segment of chromosome 3p22- p21.3. (PMID: 10231028) Daigo Y. … Nakamura Y. (DNA Res. 1999) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers. (PMID: 19282870) Irshad S. … Grimm S. (Cell Death Differ. 2009) 3 22 64

Products for SLC22A13 Gene

Sources for SLC22A13 Gene

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