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Aliases for SLC22A13 Gene

Aliases for SLC22A13 Gene

  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 13 2 3
  • Solute Carrier Family 22 (Organic Anion Transporter), Member 13 2 3
  • Organic Cationic Transporter-Like 3 2 3
  • Organic Cation Transporter-Like 3 3 4
  • ORCTL-3 3 4
  • ORCTL3 3 4
  • OCTL1 3 4
  • Solute Carrier Family 22, Member 13 3
  • Solute Carrier Family 22 Member 13 3
  • Organic-Cation Transporter Like 3 3
  • OAT10 3
  • OCTL3 3

External Ids for SLC22A13 Gene

Previous Symbols for SLC22A13 Gene

  • ORCTL3

Summaries for SLC22A13 Gene

Entrez Gene Summary for SLC22A13 Gene

  • This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]

GeneCards Summary for SLC22A13 Gene

SLC22A13 (Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 13) is a Protein Coding gene. GO annotations related to this gene include organic cation transmembrane transporter activity. An important paralog of this gene is SLC22A12.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A13 Gene

Genomics for SLC22A13 Gene

Genomic Location for SLC22A13 Gene

Start:
38,265,807 bp from pter
End:
38,278,670 bp from pter
Size:
12,864 bases
Orientation:
Plus strand

Genomic View for SLC22A13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A13 Gene

Regulatory Elements for SLC22A13 Gene

Proteins for SLC22A13 Gene

  • Protein details for SLC22A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y226-S22AD_HUMAN
    Recommended name:
    Solute carrier family 22 member 13
    Protein Accession:
    Q9Y226
    Secondary Accessions:
    • B2RCV9
    • Q8IYG1

    Protein attributes for SLC22A13 Gene

    Size:
    551 amino acids
    Molecular mass:
    60862 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A13 Gene

Proteomics data for SLC22A13 Gene at MOPED

Post-translational modifications for SLC22A13 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn57, Asn61, Asn92, and Asn104

Other Protein References for SLC22A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A13 Gene

Domains for SLC22A13 Gene

Gene Families for SLC22A13 Gene

Protein Domains for SLC22A13 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S22AD_HUMAN
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.:
    • Q9Y226
genes like me logo Genes that share domains with SLC22A13: view

Function for SLC22A13 Gene

Gene Ontology (GO) - Molecular Function for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015101 organic cation transmembrane transporter activity NAS 10072596
GO:0022857 transmembrane transporter activity --
GO:0090416 nicotinate transporter activity IDA 18411268
genes like me logo Genes that share ontologies with SLC22A13: view

miRNA for SLC22A13 Gene

miRTarBase miRNAs that target SLC22A13

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC22A13 Gene

Localization for SLC22A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A13 Gene COMPARTMENTS Subcellular localization image for SLC22A13 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane NAS 10072596
GO:0016021 integral component of membrane --
GO:0016324 apical plasma membrane IDA 18411268
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC22A13: view

Pathways for SLC22A13 Gene

SuperPathways for SLC22A13 Gene

No Data Available

Interacting Proteins for SLC22A13 Gene

Gene Ontology (GO) - Biological Process for SLC22A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015695 organic cation transport NAS 10072596
GO:0015747 urate transport IDA 10072596
GO:0055085 transmembrane transport IEA --
GO:2001142 nicotinate transport IDA 18411268
genes like me logo Genes that share ontologies with SLC22A13: view

No data available for Pathways by source for SLC22A13 Gene

Transcripts for SLC22A13 Gene

mRNA/cDNA for SLC22A13 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC22A13 Gene

Solute carrier family 22 (organic anion transporter), member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -

Relevant External Links for SLC22A13 Gene

GeneLoc Exon Structure for
SLC22A13
ECgene alternative splicing isoforms for
SLC22A13

Expression for SLC22A13 Gene

mRNA expression in normal human tissues for SLC22A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A13 Gene

This gene is overexpressed in Kidney - Cortex (17.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC22A13 Gene

SOURCE GeneReport for Unigene cluster for SLC22A13 Gene Hs.225941

mRNA Expression by UniProt/SwissProt for SLC22A13 Gene

Q9Y226-S22AD_HUMAN
Tissue specificity: Ubiquitous, expressed at low levels.
genes like me logo Genes that share expressions with SLC22A13: view

Orthologs for SLC22A13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC22A13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A13 36
  • 99.46 (n)
  • 99.64 (a)
SLC22A13 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A13 36
  • 77.82 (n)
  • 68.21 (a)
SLC22A13 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A13 36
  • 83.18 (n)
  • 80.94 (a)
SLC22A13 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc22a13 36
  • 79.13 (n)
  • 73.32 (a)
Slc22a13 16
Slc22a13 37
  • 73 (a)
OneToMany
Slc22a13b-ps 37
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC22A13 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 53 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc22a13 36
  • 77.98 (n)
  • 72.96 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 47 (a)
OneToMany
-- 37
  • 48 (a)
OneToMany
SLC22A13 36
  • 58.74 (n)
  • 50.75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 49 (a)
OneToMany
-- 37
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SLC22A13 37
  • 48 (a)
OneToOne
zgc:153639 36
  • 53.74 (n)
  • 47.5 (a)
Species with no ortholog for SLC22A13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC22A13 Gene

ENSEMBL:
Gene Tree for SLC22A13 (if available)
TreeFam:
Gene Tree for SLC22A13 (if available)

Paralogs for SLC22A13 Gene

genes like me logo Genes that share paralogs with SLC22A13: view

Variants for SLC22A13 Gene

Sequence variations from dbSNP and Humsavar for SLC22A13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs149836 -- 38,274,330(+) CATGG(C/G)TGGGC reference, missense, nc-transcript-variant
rs149837 -- 38,276,886(+) GTCTA(A/C)TTAGC intron-variant
rs149838 -- 38,278,895(+) CCTTC(C/T)TCAGC downstream-variant-500B
rs169198 -- 38,278,418(+) AATGA(A/G)CAATA downstream-variant-500B, nc-transcript-variant
rs194686 -- 38,278,820(+) atctc(A/C)aaaaa downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC22A13 Gene

Variant ID Type Subtype PubMed ID
nsv3769 CNV Insertion 18451855
nsv528237 CNV Loss 19592680

Relevant External Links for SLC22A13 Gene

HapMap Linkage Disequilibrium report
SLC22A13

Disorders for SLC22A13 Gene

Relevant External Links for SLC22A13

Genetic Association Database (GAD)
SLC22A13
Human Genome Epidemiology (HuGE) Navigator
SLC22A13
genes like me logo Genes that share disorders with SLC22A13: view

No data available for UniProtKB/Swiss-Prot for SLC22A13 Gene

Publications for SLC22A13 Gene

  1. Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. (PMID: 10072596) Nishiwaki T. … Nakamura Y. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  2. Characterization of a 1200-kb genomic segment of chromosome 3p22- p21.3. (PMID: 10231028) Daigo Y. … Nakamura Y. (DNA Res. 1999) 3 4 23
  3. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). (PMID: 18411268) Bahn A. … Burckhardt G. (J. Biol. Chem. 2008) 2 3 23
  4. Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers. (PMID: 19282870) Irshad S. … Grimm S. (Cell Death Differ. 2009) 3 23
  5. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. (PMID: 19536068) Tzvetkov M.V. … BrockmAPller J. (Clin. Pharmacol. Ther. 2009) 3 49

Products for SLC22A13 Gene

Sources for SLC22A13 Gene

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