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SLC22A12 Gene

protein-coding   GIFtS: 56
GCID: GC11P064359

Solute Carrier Family 22 (Organic Anion/Urate Transporter),...

(Previous names: solute carrier family 22 (organic anion/cation transporter),...)
  See SLC22A12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member
121 2
     RST2 3
URAT12 3 5     OAT4L2 5
Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 121 2     Solute Carrier Family 22 Member 122
Organic Anion Transporter 4-Like Protein2 3     Urate Transporter 12
Renal-Specific Transporter2 3     OATL43
Urate Anion Exchanger 12 3     

External Ids:    HGNC: 179891   Entrez Gene: 1160852   Ensembl: ENSG000001978917   OMIM: 6070965   UniProtKB: Q96S373   

Export aliases for SLC22A12 gene to outside databases

Previous GC identifers: GC11P066873 GC11P066039 GC11P064609 GC11P064099 GC11P064100 GC11P064115 GC11P060685


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A12 Gene:
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate
transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in
epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is
associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for SLC22A12 Gene:
SLC22A12 (solute carrier family 22 (organic anion/urate transporter), member 12) is a protein-coding gene. Diseases associated with SLC22A12 include renal hypouricemia 1, and renal hypouricemia. GO annotations related to this gene include PDZ domain binding and urate transmembrane transporter activity. An important paralog of this gene is SLC22A11.

UniProtKB/Swiss-Prot: S22AC_HUMAN, Q96S37
Function: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates
saturable urate uptake by facilitating the exchange of urate against organic anions

Gene Wiki entry for SLC22A12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A12 gene promoter:
         Bach1   GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC22A12 promoter sequence
   Search Chromatin IP Primers for SLC22A12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

SLC22A12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A12 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064359:  view genomic region     (about GC identifiers)

Start:
64,358,113 bp from pter      End:
64,369,820 bp from pter
Size:
11,708 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S22AC_HUMAN, Q96S37 (See protein sequence)
Recommended Name: Solute carrier family 22 member 12  
Size: 553 amino acids; 59630 Da
Subunit: Interacts with PDZK1
Sequence caution: Sequence=BAB68364.1; Type=Frameshift; Positions=84, 136;
Secondary accessions: B7WPG1 Q19PF7 Q19PF8 Q19PF9 Q19PG0 Q6UXW3 Q96DT2
Alternative splicing: 2 isoforms:  Q96S37-1   Q96S37-2   

Explore the universe of human proteins at neXtProt for SLC22A12: NX_Q96S37

Explore proteomics data for SLC22A12 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56, Asn102
  • Modification sites at PhosphoSitePlus

  • See SLC22A12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001263255.1  NP_001263256.1  NP_653186.2  NP_700357.1  

    ENSEMBL proteins: 
     ENSP00000366790   ENSP00000366797   ENSP00000438437   ENSP00000336836   ENSP00000366795  
    Reactome Protein details: Q96S37

    SLC22A12 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Urate anion exchanger 1
    Urate transporter

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q96S37

    ProtoNet protein and cluster: Q96S37

    UniProtKB/Swiss-Prot: S22AC_HUMAN, Q96S37
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22AC_HUMAN, Q96S37
    Function: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates
    saturable urate uptake by facilitating the exchange of urate against organic anions

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0015143urate transmembrane transporter activity IDA12024214
    GO:0022857transmembrane transporter activity ----
    GO:0030165PDZ domain binding IPI15304510
         
    Find genes that share ontologies with SLC22A12           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc22a12):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  mortality/aging  nervous system  renal/urinary system 
     reproductive system 

    Find genes that share phenotypes with SLC22A12           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC22A12
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC22A12
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    SwitchGear 3'UTR luciferase reporter plasmidSLC22A12 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22AC_HUMAN, Q96S37: Cell membrane; Multi-pass membrane protein. Note=Detected in the luminal membrane of the
    epithelium of renal proximal tubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IDA12024214
    GO:0016324apical plasma membrane IDA12024214
    GO:0031526brush border membrane NAS12024214
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLC22A12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC22A12 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Organic anion transport0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Uric Acid-Lowering Drugs Pathway, Pharmacodynamics
    Uric Acid-Lowering Drugs Pathway, Pharmacodynamics


    Find genes that share SuperPaths with SLC22A12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC22A12
        Organic anion transport

    1 PharmGKB Pathway for SLC22A12
        Uric Acid-Lowering Drugs Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A12
    Interactions:

        GeneGlobe Interaction Network for SLC22A12

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC22A12 (Q96S373 ENSP000003667974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDZK1Q5T2W13, ENSP000003421434I2D: score=2 STRING: ENSP00000342143
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015747urate transport IDA12024214
    GO:0015849organic acid transport IDA12024214
    GO:0019725cellular homeostasis NAS15772301
    GO:0042493response to drug IDA12024214
    GO:0046415urate metabolic process IMP19503597

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A12 (S22AC)

    7 Novoseek inferred chemical compound relationships for SLC22A12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uric acid 88.6 132 18824160 (5), 14694169 (4), 14747372 (4), 16678460 (3) (see all 38)
    benzbromarone 87.8 13 16135657 (3), 18670416 (3), 14694169 (2), 20075570 (1)
    probenecid 55.9 5 14694169 (2), 16678460 (1)
    losartan 52.9 14 18670416 (7), 20075570 (1), 20329654 (1), 17043154 (1)
    pyrazinamide 45.8 5 14694169 (2), 16678460 (1)
    creatinine 44.1 3 14694169 (1), 18824160 (1)
    carnitine 29.2 1 12883891 (1)

    4 PharmGKB related drug/compound annotations for SLC22A12 gene    About this table
    Drug/compound PharmGKB Annotation
    cytarabineCA  
    fludarabineCA  
    gemtuzumab ozogamicinCA  
    idarubicinCA  



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A12 gene (4 alternative transcripts): 
    NM_001276326.1  NM_001276327.1  NM_144585.3  NM_153378.2  

    Unigene Cluster for SLC22A12:

    Solute carrier family 22 (organic anion/urate transporter), member 12
    Hs.174424  [show with all ESTs]
    Unigene Representative Sequence: AB050269
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377567 ENST00000377574(uc009ypr.1 uc009ypt.3 uc001oal.1 uc001oam.1 uc009yps.1)
    ENST00000473690 ENST00000336464 ENST00000377572(uc001oan.1)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SLC22A12:
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    Additional mRNA sequence: 

    AB050269.1 AB071863.1 AK055737.1 AK122599.1 AK309588.1 AK315061.1 AY358183.1 BC053348.1 
    DQ655911.2 DQ655912.2 

    3 DOTS entries:

    DT.305438  DT.95159092  DT.101981744 

    24 AceView cDNA sequences:

    NM_144585 BC026291 BX104022 AW135864 NM_153378 AW204139 AI733516 AK122599 
    AK055737 AB050269 AI017817 AA913525 BC053348 AB071863 AA913088 AI792236 
    BX280188 BI760942 AY358183 BI759333 BI762217 BG428879 AW025396 BM924717 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A12    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                          -                 -                                             
    SP2:                                                                                          
    SP3:                                            -     -                                       
    SP4:        -     -                                                                           


    ECgene alternative splicing isoforms for SLC22A12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC22A12 Expression
    About this image


    SLC22A12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)
             Proximal Tubule Cells Proximal Tubule
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Prostate (Endocrine System)
    SLC22A12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.174424

    UniProtKB/Swiss-Prot: S22AC_HUMAN, Q96S37
    Tissue specificity: Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in
    epithelial cells of proximal tubules in renal cortex

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SLC22A12 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc22a121 , 5 solute carrier family 22 (organic anion/cation transporter), more1, 5 78.06(n)1
    73.96(a)1
      19 (5.05 cM)5
    205211  NM_009203.31  NP_033229.31 
     65358455 


    ENSEMBL Gene Tree for SLC22A12 (if available)
    TreeFam Gene Tree for SLC22A12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A12 gene
    SLC22A112  SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  
    SLC22A132  SLC22A92  SLC22A62  SLC22A152  SLC22A72  SLC22A162  SLC22A32  SLC22A252  
    18 SIMAP similar genes for SLC22A12 using alignment to 5 protein entries:     S22AC_HUMAN (see all proteins):
    SLC22A11    UST6    SLC22A6    SLC22A25    SLC22A24    OAT7
    SLC22A8    SLC22A9    SLC22A20    SLC22A10    SLC22A13    HMFN2567
    SLC22A7    SLC22A2    SLC22A3    SLC22A4    SLC22A1    SLC22A16

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A12 (see all 514)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0367234
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367232 V M mis40--------
    VAR_0367254
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367252 T M mis40--------
    VAR_0367304
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367302 E D mis40--------
    VAR_0367244
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367242 G S mis40--------
    VAR_0367364
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367362 M T mis40--------
    VAR_0367354
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367352 L R mis40--------
    VAR_0367344
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367342 Q L mis40--------
    VAR_0367214
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367212 R H mis40--------
    VAR_0367374
    Hypouricemia renal 1 (RHUC1)4--see VAR_0367372 R H mis40--------
    rs1219078961,2
    Cpathogenic164278637(+) CCGCCA/GCTTCC 7 H R mis1 ut510--------

    HapMap Linkage Disequilibrium report for SLC22A12 (64358113 - 64369820 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SLC22A12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744627CNV Deletion23290073
    esv2422214CNV Deletion17116639
    nsv528506CNV Loss19592680
    nsv897696CNV Loss21882294
    nsv897693CNV Loss21882294
    nsv897694CNV Loss21882294
    nsv897692CNV Loss21882294
    dgv1171n71CNV Loss21882294
    nsv818842CNV Gain17921354
    nsv832188CNV Gain17160897

    Human Gene Mutation Database (HGMD): SLC22A12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A12
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607096   
    OMIM disorders: 220150  
    UniProtKB/Swiss-Prot: S22AC_HUMAN, Q96S37
  • Hypouricemia renal 1 (RHUC1) [MIM:220150]: A disorder characterized by impaired uric acid reabsorption at
    the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear
    asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and
    nephrolithiasis. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for SLC22A12:    
    About MalaCards
    renal hypouricemia 1    renal hypouricemia    gout    hyperuricemia

    3 diseases from the University of Copenhagen DISEASES database for SLC22A12:
    Hyperuricemia     Gout     Nephrolithiasis

    Find genes that share disorders with SLC22A12           About GenesLikeMe

    5 Novoseek inferred disease relationships for SLC22A12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypouricemia, renal 98.2 30 14694169 (4), 15772829 (3), 16703794 (3), 18492088 (2) (see all 13)
    hypouricemia 92.5 4 20075570 (1), 18670416 (1), 16703794 (1)
    hyperuricemia 84.9 9 19833602 (2), 16901081 (1), 16920156 (1), 17278928 (1) (see all 5)
    gout 75 2 16920156 (1), 17278928 (1)
    renal failure acute 64.1 1 15772829 (1)

    Genetic Association Database (GAD): SLC22A12
    Human Genome Epidemiology (HuGE) Navigator: SLC22A12 (16 documents)

    Export disorders for SLC22A12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A12 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with SLC22A12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout. (PubMed id 16837472)1, 2, 4, 9 Vazquez-Mellado J.... Burgos-Vargas R. (Rheumatology 2007)
    2. Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. (PubMed id 16385546)1, 2, 4, 9 Graessler J.... Schroeder H.-E. (Arthritis Rheum. 2006)
    3. A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. (PubMed id 15327384)1, 2, 4 Iwai N.... Endou H. (Kidney Int. 2004)
    4. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. (PubMed id 12024214)1, 2, 3 Enomoto A.... Endou H. (Nature 2002)
    5. Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. (PubMed id 14694169)1, 2, 9 Ichida K.... Hosoya T. (J. Am. Soc. Nephrol. 2004)
    6. T6092C polymorphism of SLC22A12 gene is associated with serum uric acid concentrations in Korean male subjects. (PubMed id 18824160)1, 4, 9 Jang W.C....Kim S.K. ( international journal of clinical chemistry 2008)
    7. Prevalence of hypouricaemia and SLC22A12 mutations in healthy Korean subjects. (PubMed id 19019168)1, 4, 9 Lee J.H....Cheong H.I. (Nephrology (Carlton) 2008)
    8. Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese. (PubMed id 16920156)1, 4, 9 Shima Y....Ohta H. (Life Sci. 2006)
    9. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PubMed id 19890391)1, 4, 9 Stark K....Hengstenberg C. (PLoS ONE 2009)
    10. Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. (PubMed id 21768215)1, 4 Tin A....KAPttgen A. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116085 HGNC: 17989 AceView: SLC22A12 Ensembl:ENSG00000197891 euGenes: HUgn116085
    ECgene: SLC22A12 H-InvDB: SLC22A12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC22A12 gene:
    Search GeneIP for patents involving SLC22A12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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