SLC22A12 Gene

Aliases
for SLC22A12 gene

Previous GC identifers: GC11P066873 GC11P066039 GC11P064609 GC11P064099 GC11P064100 GC11P064115 GC11P060685

Summaries
for SLC22A12 gene

Genomic Views
for SLC22A12 gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.1  NT_167190.1  

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC22A12 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A12

SLC22A12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064359:  view genomic region     (about GC identifiers)

Proteins
for SLC22A12 gene

Explore the universe of human proteins at neXtProt for SLC22A12: NX_Q96S37

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SLC22A12 OriGene Custom Protein Services for SLC22A12
	GenScript Custom Purified and Recombinant Proteins Services for SLC22A12
	Novus Biologicals SLC22A12 Proteins Novus Biologicals SLC22A12 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC22A12

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC22A12
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	Browse OriGene Antibodies OriGene Custom Antibody Services for SLC22A12
	GenScript Custom Superior Antibodies Services for SLC22A12
	Novus Biologicals SLC22A12 Antibodies
	Search for Antibodies for SLC22A12 at Abcam
	Uscn Antibodies for SLC22A12
	Search ThermoFisher Antibodies for SLC22A12

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC22A12
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLC22A12

Protein Domains /
Families
for SLC22A12 gene

ProtoNet protein and cluster: Q96S37

Function
for SLC22A12 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC22A12
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SLC22A12:
		hsa-miR-1291
		SwitchGear 3'UTR luciferase reporter plasmid: SLC22A12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC22A12 (see all 7) OriGene shRNA RFP: SLC22A12 OriGene siRNA: SLC22A12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC22A12

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SLC22A12

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A12 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SLC22A12 (NM_144585)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC22A12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC22A12
		Search LifeMap BioReagents cell lines for SLC22A12

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A12

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Slc22a12)

Pathways & Interactions
for SLC22A12 gene

	Super-pathway	contained gene-specific pathways
1	SLC-mediated transmembrane transport	SLC-mediated transmembrane transport 1.00 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.38 Transmembrane transport of small molecules 0.50
2	Organic cation/anion/zwitterion transport	Organic cation/anion/zwitterion transport 1.00 Organic anion transport 0.38
3	Antigout Preparations Pathway, Pharmacodynamics	Antigout Preparations Pathway, Pharmacodynamics 1.00

5        Reactome Pathways for SLC22A12

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Organic cation/anion/zwitterion transport
	Organic anion transport

1 PharmGKB Pathway for SLC22A12

Antigout Preparations Pathway, Pharmacodynamics

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SLC22A12 gene

Transcripts
for SLC22A12 gene

Expression
for SLC22A12 gene

SLC22A12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyProximal TubuleProximal Tubule Cells			Kidney
	Skeletal MuscleHyoid Arch MusclesMyoblasts			Skeletal Muscle
	Skeletal MuscleMandibular Arch MusclesMyoblasts			Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC22A12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A12

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A12

Orthologs
for SLC22A12 gene

Paralogs
for SLC22A12 gene

Paralogs for SLC22A12 gene

SLC22A11²  SLC22A5²  SLC22A8²  SLC22A1²  SLC22A24²  SLC22A4²  SLC22A9²  SLC22A2²  

SLC22A10²  SLC22A13²  SLC22A6²  SLC22A15²  SLC22A7²  SLC22A3²  SLC22A25²  SLC22A16²  

18/19 SIMAP similar genes for SLC22A12 using alignment to 5 protein entries:     S22AC_HUMAN (see all proteins) (see all similar genes):

SLC22A11    UST6    SLC22A6    SLC22A25    SLC22A24    OAT7

SLC22A8    SLC22A9    SLC22A20    SLC22A10    SLC22A13    HMFN2567

SLC22A7    SLC22A2    SLC22A3    SLC22A4    SLC22A1    SLC22A16

SLC22A12 for paralogs           About GeneDecksing

Genomic Variants
for SLC22A12 gene

10/377 NCBI SNPs in SLC22A12 are shown (see all 377)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1219078921,2	C,	pathogenic	64361219(+)	GACTGA/GACACT	4	* W	stg1		0	--	--	--	--
rs786478791,2	F,	--	64356495(+)	TGCACA/GTATTT	2	--	us2k1		1		WA	118
rs1398887071,2		--	64356517(+)	TAAACA/CGTAGT	2	--	us2k1		0	--	--	--	--
rs715817461,2	C,	--	64356541(+)	TGATGA/TGTATA	2	--	us2k1		2		CSA WA	120
rs1454061411,2		--	64356736(+)	ACCAGA/GAGCTC	2	--	us2k1		0	--	--	--	--
rs5075361,2	C,F,A,H,	--	64356912(-)	CTACAC/ACTAGG	2	--	us2k1		27		NS EA NA WA CSA	2083
rs5788291,2	C,F,A,H,	--	64356929(-)	TCTTCG/ACTTAT	2	--	us2k1		29		NS EA NA WA CSA	2303
rs1856209361,2		--	64356940(+)	GAGCCC/TGCTGG	2	--	us2k1		0	--	--	--	--
rs1904921481,2		--	64356941(+)	AGCCCA/GCTGGA	2	--	us2k1		0	--	--	--	--
rs715817481,2	C,F,	--	64356942(+)	GCCCGC/TTGGAG	2	--	us2k1		2		WA EA	238

HapMap Linkage Disequilibrium report for SLC22A12 (64358113 - 64369820 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SLC22A12
     3 CNVs: 9667 4752 5422
Human Gene Mutation Database (HGMD): SLC22A12

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A12

DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A12

Disorders / Diseases
for SLC22A12 gene

13 diseases for SLC22A12

5 Novoseek disease relationships for SLC22A12 gene    About this table

Publications
for SLC22A12 gene

PubMed articles for SLC22A12 gene, integrated from 9 sources (see all 88): (articles sorted by number of sources associating them with SLC22A12)

Utopia: connect your pdf to the dynamic world of online information

1. Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. (PubMed id 16385546)^{1, 2, 4, 9} Graessler J.... Schroeder H.-E. (2006)
2. A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. (PubMed id 15327384)^{1, 2, 4} Iwai N.... Endou H. (2004)
3. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. (PubMed id 12024214)^{1, 2, 3} Enomoto A.... Endou H. (2002)
4. Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout. (PubMed id 16837472)^{1, 2, 9} Vazquez-Mellado J.... Burgos-Vargas R. (2007)
5. Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. (PubMed id 14694169)^{1, 2, 9} Ichida K.... Hosoya T. (2004)
6. Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload. (PubMed id 15338274)^{1, 4} Zaahl M.G.... Robson K.J.H. (2004)
7. The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. (PubMed id 15304510)^{1, 2} Anzai N....Endou H. (2004)
8. PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. (PubMed id 14531806)^{1, 2} Gisler S.M.... Murer H. (2003)
9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
10. Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients. (PubMed id 18670416)^{1, 9} Hamada T....Hisatome I. (2008)

External Searches for SLC22A12 gene

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Products
for SLC22A12 gene