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SLC22A11 Gene

protein-coding   GIFtS: 58
GCID: GC11P064324

Solute Carrier Family 22 (Organic Anion/Urate Transporter),...

  See SLC22A11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member
111 2
OAT42 3 5
Organic Anion Transporter 42 3
hOAT42
Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 112
Solute Carrier Family 22 Member 112

External Ids:    HGNC: 181201   Entrez Gene: 558672   Ensembl: ENSG000001680657   OMIM: 6070975   UniProtKB: Q9NSA03   

Export aliases for SLC22A11 gene to outside databases

Previous GC identifers: GC11P066839 GC11P066004 GC11P064573 GC11P064098 GC11P064079 GC11P060650


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC22A11 Gene:
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions,
some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in
the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the
fetus. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC22A11 Gene:
SLC22A11 (solute carrier family 22 (organic anion/urate transporter), member 11) is a protein-coding gene. Diseases associated with SLC22A11 include cardiovascular disease risk factor. GO annotations related to this gene include inorganic anion exchanger activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A5.

UniProtKB/Swiss-Prot: S22AB_HUMAN, Q9NSA0
Function: Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds

Gene Wiki entry for SLC22A11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC22A11 gene promoter:
         Tal-1   p53   Lmo2   MIF-1   Tal-1beta   E47   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC22A11 promoter sequence
   Search Chromatin IP Primers for SLC22A11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC22A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.3

SLC22A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC22A11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064324:  view genomic region     (about GC identifiers)

Start:
64,323,098 bp from pter      End:
64,340,347 bp from pter
Size:
17,250 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S22AB_HUMAN, Q9NSA0 (See protein sequence)
Recommended Name: Solute carrier family 22 member 11  
Size: 550 amino acids; 59972 Da
Sequence caution: Sequence=BAC11483.1; Type=Erroneous initiation;
Secondary accessions: A8K426 Q53GR2 Q6ZP72 Q8NBU4
Alternative splicing: 2 isoforms:  Q9NSA0-1   Q9NSA0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC22A11: NX_Q9NSA0

Explore proteomics data for SLC22A11 at MOPED

Post-translational modifications: 

  • N-glycosylated. Contains several complex-type N-glycans1
  • Glycosylation2 at Asn39, Asn56, Asn99

  • See SLC22A11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060954.1  
    ENSEMBL proteins: 
     ENSP00000301891   ENSP00000366809   ENSP00000366804   ENSP00000394043   ENSP00000413508  
    Reactome Protein details: Q9NSA0

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    Cloud-Clone Corp. Proteins for SLC22A11

     
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    antibodies-online peptides for SLC22A11

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Organic anion transporter 4
    Organic anion transporters (OATs)

    3 InterPro protein domains:
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9NSA0

    ProtoNet protein and cluster: Q9NSA0

    UniProtKB/Swiss-Prot: S22AB_HUMAN, Q9NSA0
    Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19)
    family


    Find genes that share domains with SLC22A11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S22AB_HUMAN, Q9NSA0
    Function: Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005452inorganic anion exchanger activity IDA15037815
    GO:0005515protein binding IPI16236806
    GO:0008514organic anion transmembrane transporter activity IDA15102942
    GO:0015347sodium-independent organic anion transmembrane transporter activity IDA10660625
    GO:0022857transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC22A11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC22A11:
     Decreased viability with pacli 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC22A11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S22AB_HUMAN, Q9NSA0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA10660625
    GO:0009897external side of plasma membrane IDA15102942
    GO:0016021integral component of membrane ----
    GO:0016324apical plasma membrane IDA15037815

    Find genes that share ontologies with SLC22A11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC22A11 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Organic cation/anion/zwitterion transport0.00
    Transmembrane transport of small molecules0.47
    Organic anion transport0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics
    Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics


    Find genes that share SuperPaths with SLC22A11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC22A11
        Organic anion transport

    1 PharmGKB Pathway for SLC22A11
        Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC22A11
    Interactions:

        GeneGlobe Interaction Network for SLC22A11

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC22A11 (Q9NSA03 ENSP000003018914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAV3P565393, ENSP000003419404I2D: score=1 STRING: ENSP00000341940
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    RRP1BQ146843, ENSP000003391454I2D: score=1 STRING: ENSP00000339145
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015711organic anion transport IDA10660625
    GO:0046415urate metabolic process IMP19503597
    GO:0055085transmembrane transport TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC22A11 (S22AB)

    Selected DrugBank Compounds for SLC22A11 (see all 36)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Probenecid-- 57-66-9targetinhibitor12023506 15377641 12130730 12063169
    transporterinhibitor12023506 15377641 12130730 12063169 12023506 14978359 12130730 12063169
    IndomethacinIMN (see all 9)53-86-1transporterinhibitor10660625 12130730 12063169
    AminohippurateAminohippurate Sodium (see all 7)94-16-6transportersubstrate inhibitor10660625 12063169
    IbuprofenIbuprophen (see all 3)15687-27-1transporterinhibitor10660625 12130730
    Penicillin G-- 61-33-6transporterinhibitor12130730 12063169
    Piroxicam-- 36322-90-4transporterinhibitor12130730 12063169
    Aspartame1-Methyl N-L-alpha-aspartyl-L-phenylalanate (see all 17)22839-47-0transporterinhibitor12063169
    BumetanideBumetanida [INN-Spanish] (see all 2)28395-03-1transporterinhibitor10660625
    Caprylic acidcapryloate (see all 14)124-07-2transporterinhibitor12063169
    CefalotinCefalothin (see all 9)153-61-7transporterinhibitor11909604

    2 Novoseek inferred chemical compound relationships for SLC22A11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrone sulfate 88 4 18414001 (2), 17020956 (1)
    probenecid 72.8 1 15377641 (1)



    Find genes that share compounds with SLC22A11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC22A11 gene: 
    NM_018484.2  

    Unigene Cluster for SLC22A11:

    Solute carrier family 22 (organic anion/urate transporter), member 11
    Hs.220844  [show with all ESTs]
    Unigene Representative Sequence: NM_018484
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301891(uc001oai.3 uc009ypq.3) ENST00000377585 ENST00000377581
    ENST00000490834 ENST00000478051(uc001oah.1) ENST00000460745(uc001oak.1)
    ENST00000428570 ENST00000416590
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    Additional mRNA sequence: 

    AB026116.1 AK075127.1 AK075224.1 AK129930.1 AK222869.1 AK290791.1 AK296083.1 AK309931.1 
    BC034384.1 

    10 DOTS entries:

    DT.432977  DT.40237838  DT.100835357  DT.100685067  DT.100809906  DT.92047748  DT.100709779  DT.91771309 
    DT.95369012  DT.120751886 

    Selected AceView cDNA sequences (see all 88):

    AB026116 BX387248 CR605725 NM_018484 AK075224 AK129930 BG002010 CR608154 
    CR598571 BC034384 BF990361 BF995387 BI759874 CB960731 BX396736 N54154 
    BX382356 CD629298 CD629300 BX381268 BI765388 BX381267 BX397168 BX358386 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A11 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                    -                                               -     -           -                     
    SP2:                    -                                               -     -     -     -     -               
    SP3:                    -     -                       -     -                                                   
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SLC22A11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC22A11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTACACC
    SLC22A11 Expression
    About this image


    SLC22A11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
     
     Kidney (Urinary System)
    SLC22A11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC22A11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.220844

    UniProtKB/Swiss-Prot: S22AB_HUMAN, Q9NSA0
    Tissue specificity: Detected in placenta and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for SLC22A11 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia SLC22A111 solute carrier family 22 (organic anion/urate transporter), more 80.72(n)
    73.18(a)
      612103  XM_849831.2  XP_854924.2 


    ENSEMBL Gene Tree for SLC22A11 (if available)
    TreeFam Gene Tree for SLC22A11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC22A11 gene
    SLC22A52  SLC22A82  SLC22A12  SLC22A242  SLC22A42  SLC22A22  SLC22A102  SLC22A132  
    SLC22A92  SLC22A62  SLC22A152  SLC22A122  SLC22A72  SLC22A162  SLC22A32  SLC22A252  
    18 SIMAP similar genes for SLC22A11 using alignment to 4 protein entries:     S22AB_HUMAN (see all proteins):
    SLC22A12    HMFN2567    SLC22A10    SLC22A25    UST6    SLC22A24
    OAT7    SLC22A9    SLC22A6    SLC22A8    SLC22A20    SLC22A13
    SLC22A7    SLC22A1    SLC22A5    SLC22A2    SLC22A3    SLC22A4

    Find genes that share paralogs with SLC22A11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC22A11 (see all 420)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777353751,2
    F--64321110(+) CAGTTC/TCAGGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1142729271,2
    F--64321159(+) CCCCAA/GGCAGC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1911137491,2
    --64321310(+) AAAGGA/GCAGGG 1 -- us2k10--------
    rs1473307661,2
    C--64321345(+) TGGACA/GGAGGA 1 -- us2k10--------
    rs1406726781,2
    --64321391(+) GATTCC/TGGCAG 1 -- us2k10--------
    rs1170770751,2
    F--64321430(+) AAGGCC/TCGGGC 1 -- us2k11Minor allele frequency- T:0.04NA 120
    rs1446220901,2
    --64321473(+) TAAAAC/TGTGCA 1 -- us2k10--------
    rs1478896751,2
    --64321513(+) CGCTCA/CAGAAA 1 -- us2k10--------
    rs1827120451,2
    --64321531(+) CTAGCC/TAGCAC 1 -- us2k10--------
    rs1861712641,2
    --64321720(+) TTGCAC/TGTTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC22A11 (64323098 - 64340347 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC22A11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422214CNV Deletion17116639
    nsv897693CNV Loss21882294
    nsv897694CNV Loss21882294
    nsv897692CNV Loss21882294
    nsv825945CNV Gain20364138
    nsv832188CNV Gain17160897

    Human Gene Mutation Database (HGMD): SLC22A11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC22A11
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC22A11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607097    OMIM disorders: --

    1 disease for SLC22A11:    
    About MalaCards
    cardiovascular disease risk factor

    1 disease from the University of Copenhagen DISEASES database for SLC22A11:
    Gout

    Find genes that share disorders with SLC22A11           About GenesLikeMe

    Genetic Association Database (GAD): SLC22A11
    Human Genome Epidemiology (HuGE) Navigator: SLC22A11 (9 documents)

    Export disorders for SLC22A11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC22A11 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with SLC22A11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. (PubMed id 10660625)1, 2, 3, 7 Cha S.H.... Endou H. (J. Biol. Chem. 2000)
    2. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. (PubMed id 15576633)1, 2, 3 Zhou F.... You G. (Mol. Pharmacol. 2005)
    3. Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients. (PubMed id 18414001)1, 4, 9 Lee W.K....Cha S.H. (Mol. Cells 2008)
    4. Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. (PubMed id 11907186)1, 7, 9 Kimura H.... Endou H. (J. Pharmacol. Exp. Ther. 2002)
    5. Human organic anion transporters mediate the transport of tetracycline. (PubMed id 11855680)1, 7, 9 Babu E.... Endou H. (Jpn. J. Pharmacol. 2002)
    6. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. (PubMed id 19861489)1, 4 van der Harst P....Navis G. (Hum. Mol. Genet. 2010)
    7. Gender is an important determinant of the disposition of the loop diuretic torasemide. (PubMed id 19934028)1, 4 Werner U....Zolk O. (J Clin Pharmacol 2010)
    8. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. (PubMed id 20884846)1, 4 Yang Q....Coresh J. (Circ Cardiovasc Genet 2010)
    9. Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study. (PubMed id 19400747)1, 4 RodrA-guez-NA^voa S....Owen A. (Clin. Infect. Dis. 2009)
    10. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. (PubMed id 19503597)1, 4 Kolz M....Gieger C. (PLoS Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55867 HGNC: 18120 AceView: SLC22A11 Ensembl:ENSG00000168065 euGenes: HUgn55867
    ECgene: SLC22A11 H-InvDB: SLC22A11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC22A11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC22A11 gene:
    Search GeneIP for patents involving SLC22A11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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