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Aliases for SLC22A11 Gene

Aliases for SLC22A11 Gene

  • Solute Carrier Family 22 Member 11 2 3 5
  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 11 2 3
  • Organic Anion Transporter 4 3 4
  • OAT4 3 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 11 3
  • HOAT4 3

External Ids for SLC22A11 Gene

Previous GeneCards Identifiers for SLC22A11 Gene

  • GC11P066839
  • GC11P066004
  • GC11P064098
  • GC11P064079
  • GC11P064324
  • GC11P060650

Summaries for SLC22A11 Gene

Entrez Gene Summary for SLC22A11 Gene

  • The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for SLC22A11 Gene

SLC22A11 (Solute Carrier Family 22 Member 11) is a Protein Coding gene. Diseases associated with SLC22A11 include Gout and Persistent Fetal Circulation Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include transmembrane transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A11 Gene

  • Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Gene Wiki entry for SLC22A11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A11 Gene

Genomics for SLC22A11 Gene

Regulatory Elements for SLC22A11 Gene

Enhancers for SLC22A11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F064629 0.8 FANTOM5 ENCODE 12.1 +73.9 73918 1.1 CTCF HCFC1 DPF2 NR2F2 ZNF335 SMARCA4 IKZF1 IRF1 CREM NRXN2 SLC22A11 RASGRP2 GC11M064637 GC11M064638 SLC22A12
GH11F064630 0.6 ENCODE 12.1 +74.6 74598 0.2 CTCF CBX3 RNF2 L3MBTL2 HCFC1 NRF1 USF2 ZEB2 DPF2 SP1 NRXN2 SLC22A11 GC11M064637 GC11M064638 SLC22A12
GH11F064438 1.1 FANTOM5 ENCODE 11.2 -116.5 -116513 1.3 HDAC1 TBL1XR1 NFRKB ZNF121 GATA2 SMARCA5 SMAD5 ZBTB11 USF2 HDAC8 SLC22A12 NRXN2 SLC22A11 MIR1237 OTUB1 GC11P064445 ENSG00000231492
GH11F064437 0.7 FANTOM5 11.2 -118.0 -117965 0.2 HDGF ATF1 CREB3L1 ZBTB11 DPF2 ARID1B OSR2 IKZF1 ZNF341 MLLT1 SLC22A12 NRXN2 SLC22A11 MIR1237 RPS6KA4 CDC42BPG GC11P064445 ENSG00000231492
GH11F064501 0.2 ENCODE 11.1 -53.4 -53406 1.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 C11orf84 ENSG00000237410 NEAT1 NRXN2 SLC22A11 SLC22A12 MIR1237 LOC100996455 C11orf95 FAU
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC22A11 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC22A11 Gene

Chromosome:
11
Start:
64,555,626 bp from pter
End:
64,572,875 bp from pter
Size:
17,250 bases
Orientation:
Plus strand

Genomic View for SLC22A11 Gene

Genes around SLC22A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A11 Gene

Proteins for SLC22A11 Gene

  • Protein details for SLC22A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA0-S22AB_HUMAN
    Recommended name:
    Solute carrier family 22 member 11
    Protein Accession:
    Q9NSA0
    Secondary Accessions:
    • A8K426
    • Q53GR2
    • Q6ZP72
    • Q8NBU4

    Protein attributes for SLC22A11 Gene

    Size:
    550 amino acids
    Molecular mass:
    59972 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A11 Gene

Post-translational modifications for SLC22A11 Gene

  • N-glycosylated. Contains several complex-type N-glycans.
  • Glycosylation at Asn 39, Asn 56, and Asn 99
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A11 Gene

No data available for DME Specific Peptides for SLC22A11 Gene

Domains & Families for SLC22A11 Gene

Gene Families for SLC22A11 Gene

Protein Domains for SLC22A11 Gene

Suggested Antigen Peptide Sequences for SLC22A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSA0

UniProtKB/Swiss-Prot:

S22AB_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A11: view

Function for SLC22A11 Gene

Molecular function for SLC22A11 Gene

UniProtKB/Swiss-Prot Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Gene Ontology (GO) - Molecular Function for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IDA 15037815
GO:0005515 protein binding IPI 16236806
GO:0008514 organic anion transmembrane transporter activity IDA 15102942
GO:0015347 sodium-independent organic anion transmembrane transporter activity TAS --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A11: view
genes like me logo Genes that share phenotypes with SLC22A11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A11 Gene

Localization for SLC22A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A11 Gene COMPARTMENTS Subcellular localization image for SLC22A11 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10660625
GO:0009897 external side of plasma membrane IDA 15102942
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A11: view

Pathways & Interactions for SLC22A11 Gene

genes like me logo Genes that share pathways with SLC22A11: view

Gene Ontology (GO) - Biological Process for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015711 organic anion transport IDA 10660625
GO:0043252 sodium-independent organic anion transport IBA --
genes like me logo Genes that share ontologies with SLC22A11: view

No data available for SIGNOR curated interactions for SLC22A11 Gene

Drugs & Compounds for SLC22A11 Gene

(40) Drugs for SLC22A11 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved Pharma Inhibition, Inhibitor, blocker, Target, Transporter, inhibitor 27
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR 1518
Bumetanide Approved Pharma Agonist, Transporter, inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 16
Cefalotin Approved, Vet_approved Pharma Transporter, inhibitor 0
Cefamandole Approved Pharma Transporter, inhibitor 0

(2) Additional Compounds for SLC22A11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
5'-Hydroxypiroxicam
77459-78-0
genes like me logo Genes that share compounds with SLC22A11: view

Transcripts for SLC22A11 Gene

Unigene Clusters for SLC22A11 Gene

Solute carrier family 22 (organic anion/urate transporter), member 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5:
SP6: - -

Relevant External Links for SLC22A11 Gene

GeneLoc Exon Structure for
SLC22A11
ECgene alternative splicing isoforms for
SLC22A11

Expression for SLC22A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC22A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A11 Gene

This gene is overexpressed in Kidney - Cortex (x51.0).

Protein differential expression in normal tissues from HIPED for SLC22A11 Gene

This gene is overexpressed in Urine (47.7) and Placenta (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A11 Gene



Protein tissue co-expression partners for SLC22A11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC22A11 Gene:

SLC22A11

SOURCE GeneReport for Unigene cluster for SLC22A11 Gene:

Hs.220844

mRNA Expression by UniProt/SwissProt for SLC22A11 Gene:

Q9NSA0-S22AB_HUMAN
Tissue specificity: Detected in placenta and kidney.
genes like me logo Genes that share expression patterns with SLC22A11: view

Primer Products

Orthologs for SLC22A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A11 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia SLC22A11 34 35
  • 80.72 (n)
cow
(Bos Taurus)
Mammalia SLC22A11 34 35
  • 79.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A11 35
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8654 36
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK455.8a 36
  • 29 (a)
ZK455.8b 36
  • 28 (a)
K05F1.6 36
  • 27 (a)
Species where no ortholog for SLC22A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC22A11 Gene

ENSEMBL:
Gene Tree for SLC22A11 (if available)
TreeFam:
Gene Tree for SLC22A11 (if available)

Paralogs for SLC22A11 Gene

Variants for SLC22A11 Gene

Sequence variations from dbSNP and Humsavar for SLC22A11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1056255 -- 64,566,387(+) TAGAA(A/C)AAAGA intron-variant
rs111484134 -- 64,564,537(+) CAGCA(C/T)CACCA intron-variant
rs111572844 -- 64,554,771(+) ACTGC(A/G)GCGAG upstream-variant-2KB
rs111749619 -- 64,560,068(+) CCACG(C/T)CCCCT intron-variant
rs111753198 -- 64,558,748(+) CCACC(C/T)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A11 Gene

Variant ID Type Subtype PubMed ID
dgv1965n54 CNV loss 21841781
esv2422214 CNV deletion 17116639
nsv825945 CNV gain 20364138
nsv832188 CNV gain 17160897

Variation tolerance for SLC22A11 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A11 Gene

Human Gene Mutation Database (HGMD)
SLC22A11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A11 Gene

Disorders for SLC22A11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC22A11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gout
  • articular gout
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC22A11

Genetic Association Database (GAD)
SLC22A11
Human Genome Epidemiology (HuGE) Navigator
SLC22A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A11
genes like me logo Genes that share disorders with SLC22A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A11 Gene

Publications for SLC22A11 Gene

  1. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. (PMID: 10660625) Cha S.H. … Endou H. (J. Biol. Chem. 2000) 2 3 4 25 64
  2. Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients. (PMID: 18414001) Lee W.K. … Cha S.H. (Mol. Cells 2008) 3 22 46 64
  3. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. (PMID: 15576633) Zhou F. … You G. (Mol. Pharmacol. 2005) 2 3 4 64
  4. Human organic anion transporters mediate the transport of tetracycline. (PMID: 11855680) Babu E. … Endou H. (Jpn. J. Pharmacol. 2002) 3 22 25 64
  5. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. (PMID: 19861489) van der Harst P. … Navis G. (Hum. Mol. Genet. 2010) 3 46 64

Products for SLC22A11 Gene

Sources for SLC22A11 Gene

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