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Aliases for SLC22A11 Gene

Aliases for SLC22A11 Gene

  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 11 2 3
  • OAT4 3 4 6
  • Organic Anion Transporter 4 3 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 11 3
  • Solute Carrier Family 22 Member 11 3
  • HOAT4 3

External Ids for SLC22A11 Gene

Summaries for SLC22A11 Gene

Entrez Gene Summary for SLC22A11 Gene

  • The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC22A11 Gene

SLC22A11 (Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 11) is a Protein Coding gene. Diseases associated with SLC22A11 include cardiovascular disease risk factor. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include inorganic anion exchanger activity and sodium-independent organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A11 Gene

  • Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Gene Wiki entry for SLC22A11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A11 Gene

Genomics for SLC22A11 Gene

Genomic Location for SLC22A11 Gene

Start:
64,555,626 bp from pter
End:
64,572,875 bp from pter
Size:
17,250 bases
Orientation:
Plus strand

Genomic View for SLC22A11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC22A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A11 Gene

Regulatory Elements for SLC22A11 Gene

Proteins for SLC22A11 Gene

  • Protein details for SLC22A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA0-S22AB_HUMAN
    Recommended name:
    Solute carrier family 22 member 11
    Protein Accession:
    Q9NSA0
    Secondary Accessions:
    • A8K426
    • Q53GR2
    • Q6ZP72
    • Q8NBU4

    Protein attributes for SLC22A11 Gene

    Size:
    550 amino acids
    Molecular mass:
    59972 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A11 Gene

Proteomics data for SLC22A11 Gene at MOPED

Post-translational modifications for SLC22A11 Gene

Other Protein References for SLC22A11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC22A11 Gene

Domains for SLC22A11 Gene

Gene Families for SLC22A11 Gene

Protein Domains for SLC22A11 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

S22AB_HUMAN
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.:
    • Q9NSA0
genes like me logo Genes that share domains with SLC22A11: view

Function for SLC22A11 Gene

Molecular function for SLC22A11 Gene

UniProtKB/Swiss-Prot Function: Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Gene Ontology (GO) - Molecular Function for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IDA 15037815
GO:0005515 protein binding IPI 16236806
GO:0008514 organic anion transmembrane transporter activity IDA 15102942
GO:0015347 sodium-independent organic anion transmembrane transporter activity IDA 10660625
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC22A11: view

Phenotypes for SLC22A11 Gene

GenomeRNAi human phenotypes for SLC22A11:
genes like me logo Genes that share phenotypes with SLC22A11: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC22A11 Gene

Localization for SLC22A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A11 Gene COMPARTMENTS Subcellular localization image for SLC22A11 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 10660625
GO:0009897 external side of plasma membrane IDA 15102942
GO:0016021 integral component of membrane --
GO:0016324 apical plasma membrane IDA 15037815
genes like me logo Genes that share ontologies with SLC22A11: view

Pathways for SLC22A11 Gene

genes like me logo Genes that share pathways with SLC22A11: view

Gene Ontology (GO) - Biological Process for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015711 organic anion transport IDA 10660625
GO:0046415 urate metabolic process IMP 19503597
GO:0055085 transmembrane transport TAS --
GO:0098656 anion transmembrane transport IDA 15037815
genes like me logo Genes that share ontologies with SLC22A11: view

Compounds for SLC22A11 Gene

(37) Drugbank Compounds for SLC22A11 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aminohippurate
  • Aminohippurate Sodium
94-16-6 transporter substrate inhibitor
Aspartame
  • 1-Methyl N-L-alpha-aspartyl-L-phenylalanate
22839-47-0 transporter inhibitor
Bumetanide
  • Bumetanida [INN-Spanish]
28395-03-1 transporter inhibitor
Caprylic acid
  • capryloate
124-07-2 transporter inhibitor
Cefalotin
  • Cefalothin
153-61-7 transporter inhibitor

(2) Novoseek inferred chemical compound relationships for SLC22A11 Gene

Compound -log(P) Hits PubMed IDs
estrone sulfate 88 3
probenecid 72.8 1
genes like me logo Genes that share compounds with SLC22A11: view

Transcripts for SLC22A11 Gene

Unigene Clusters for SLC22A11 Gene

Solute carrier family 22 (organic anion/urate transporter), member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5:
SP6: - -

Relevant External Links for SLC22A11 Gene

GeneLoc Exon Structure for
SLC22A11
ECgene alternative splicing isoforms for
SLC22A11

Expression for SLC22A11 Gene

mRNA expression in normal human tissues for SLC22A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A11 Gene

This gene is overexpressed in Kidney - Cortex (51.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC22A11 Gene

SOURCE GeneReport for Unigene cluster for SLC22A11 Gene Hs.220844

mRNA Expression by UniProt/SwissProt for SLC22A11 Gene

Q9NSA0-S22AB_HUMAN
Tissue specificity: Detected in placenta and kidney.
genes like me logo Genes that share expressions with SLC22A11: view

Orthologs for SLC22A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A11 36
  • 99.64 (n)
  • 99.64 (a)
SLC22A11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A11 36
  • 79.24 (n)
  • 69.36 (a)
SLC22A11 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC22A11 36
  • 80.72 (n)
  • 73.18 (a)
SLC22A11 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A11 37
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8654 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea K05F1.6 38
  • 27 (a)
ZK455.8a 38
  • 29 (a)
ZK455.8b 38
  • 28 (a)
Species with no ortholog for SLC22A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC22A11 Gene

ENSEMBL:
Gene Tree for SLC22A11 (if available)
TreeFam:
Gene Tree for SLC22A11 (if available)

Paralogs for SLC22A11 Gene

genes like me logo Genes that share paralogs with SLC22A11: view

Variants for SLC22A11 Gene

Sequence variations from dbSNP and Humsavar for SLC22A11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs523237 -- 64,562,852(-) GGCCT(G/T)GGGGA intron-variant
rs693591 -- 64,557,597(-) CATGT(C/G)CCCGC intron-variant
rs1056255 -- 64,566,387(+) TAGAA(A/C)AAAGA intron-variant
rs1705364 -- 64,554,431(-) CTGGG(C/T)TTCAA upstream-variant-2KB
rs1783811 -- 64,565,824(+) CCCAA(A/G)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A11 Gene

Variant ID Type Subtype PubMed ID
nsv897692 CNV Loss 21882294
nsv897693 CNV Loss 21882294
esv2422214 CNV Deletion 17116639
nsv832188 CNV Gain 17160897
nsv825945 CNV Gain 20364138
nsv897694 CNV Loss 21882294

Relevant External Links for SLC22A11 Gene

HapMap Linkage Disequilibrium report
SLC22A11
Human Gene Mutation Database (HGMD)
SLC22A11

Disorders for SLC22A11 Gene

(1) University of Copenhagen DISEASES for SLC22A11 Gene

Relevant External Links for SLC22A11

Genetic Association Database (GAD)
SLC22A11
Human Genome Epidemiology (HuGE) Navigator
SLC22A11
genes like me logo Genes that share disorders with SLC22A11: view

No data available for UniProtKB/Swiss-Prot for SLC22A11 Gene

Publications for SLC22A11 Gene

  1. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. (PMID: 10660625) Cha S.H. … Endou H. (J. Biol. Chem. 2000) 2 3 4 25
  2. Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients. (PMID: 18414001) Lee W.K. … Cha S.H. (Mol. Cells 2008) 3 23 49
  3. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. (PMID: 15576633) Zhou F. … You G. (Mol. Pharmacol. 2005) 2 3 4
  4. Human organic anion transporters mediate the transport of tetracycline. (PMID: 11855680) Babu E. … Endou H. (Jpn. J. Pharmacol. 2002) 3 23 25
  5. Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. (PMID: 11907186) Kimura H. … Endou H. (J. Pharmacol. Exp. Ther. 2002) 3 23 25

Products for SLC22A11 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLC22A11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SLC22A11
    • Block miRNA regulation of SLC22A11 using miScript Target Protectors

    Sources for SLC22A11 Gene

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