SLC22A10 Gene
protein-coding GIFtS: 44
GCID: GC11P062905
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solute carrier family 22, member 10(Previous names: solute carrier family 22 (organic anion/cation transporter),...)
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Aliases
for SLC22A10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 22, Member 101 2 | | OAT51 2 3 | | HOAT51 | | Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 101 2 | | Organic Anion Transporter 52 3 | | Solute Carrier Family 22 Member 102 |
Export aliases for SLC22A10 gene to outside databasesPrevious GC identifers: GC11U990606 GC11P062815 GC11P063057 GC11P059386 |
Summaries
for SLC22A10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for SLC22A10
|
Genomic Views
for SLC22A10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC22A10 gene promoter:
GATA-3 HTF Pax-6 GATA-2 GATA-1 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC22A10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC22A10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.3 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12.3SLC22A10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P062905: view genomic region
(about GC identifiers)
Start:
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62,905,339 bp from pter |
End:
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63,137,190 bp from pter |
Size:
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231,852 bases |
Orientation:
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plus strand |
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Proteins
for SLC22A10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S22AA_HUMAN, Q63ZE4 (See
protein sequence)Recommended Name: Solute carrier family 22 member 10 Size: 541 amino acids; 60257 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for SLC22A10: NX_Q63ZE4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q63ZE4
SLC22A10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034841.3
ENSEMBL proteins: ENSP00000433048 ENSP00000327569 ENSP00000433817 ENSP00000433908 ENSP00000445667 ENSP00000444602
Human Recombinant Protein Products for SLC22A10:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC22A10 for ontologies About GeneDecksing
SLC22A10 Antibody Products:
Assay Products for SLC22A10: |
Protein
Domains /
Families
for SLC22A10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC22A10 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q63ZE4ProtoNet protein and cluster: Q63ZE4 UniProtKB/Swiss-Prot: S22AA_HUMAN, Q63ZE4Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family |
Function
for SLC22A10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0022857 | transmembrane transporter activity |
IEA | -- |
SLC22A10 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A10 |
|
Pathways & Interactions
for SLC22A10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC22A10
|
Drugs & Compounds
for SLC22A10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC22A10
3 DrugBank Compounds for SLC22A10 About this table
Search CenterWatch for drugs/clinical trials and news about SLC22A10 / S22AA
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Transcripts
for SLC22A10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC22A10 gene: NM_001039752.3 Unigene Cluster for SLC22A10: Solute carrier family 22, member 10 Hs.188982 [show with all ESTs]Unigene Representative Sequence: NM_0010397528 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000525620 ENST00000533483(uc001nwu.4 uc009yor.3) ENST00000533176
ENST00000332793(uc010rmp.1) ENST00000532724 ENST00000526800 ENST00000544661
ENST00000535888(uc010rmo.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC22A10 (NM_001039752) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC22A10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A10 |
Additional cDNA sequence: AK296299.1 AK298430.1 BC171744.1 4 DOTS entries: DT.100741047 DT.120717915 DT.205050 DT.95247658 18 AceView cDNA sequences: AA680184 AV652088 CB153872 CB164434 BX091233 BV190682 AB075876 CB164131 AV699858 AV684869 AA682573 AV697812 AV694507 CB156921 AV696710 AV697918 CB157359 CB162810
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A10 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC22A10
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Expression
for SLC22A10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC22A10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATACTTTTGA
About this image
See SLC22A10 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.188982
UniProtKB/Swiss-Prot: S22AA_HUMAN, Q63ZE4Tissue specificity: Detected in fetal and adult liver, and in adult kidney
SABiosciences Custom PCR Arrays for SLC22A10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLC22A10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC22A10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC22A10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A10 |
Orthologs
for SLC22A10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SLC22A10 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for SLC22A10 (if available)
TreeFam Gene Tree for SLC22A10 (if available) |
Paralogs
for SLC22A10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC22A10 gene
- SLC22A112 SLC22A52 SLC22A82 SLC22A12 SLC22A242 SLC22A42 SLC22A92 SLC22A22
- SLC22A132 SLC22A62 SLC22A152 SLC22A72 SLC22A122 SLC22A32 SLC22A162 SLC22A252
18/19 SIMAP similar genes for SLC22A10 using alignment to 5 protein entries: S22AA_HUMAN (see all proteins)
(see all similar genes):HMFN2567 SLC22A24 UST6 SLC22A25 SLC22A6 SLC22A11
OAT7 SLC22A9 SLC22A20 SLC22A8 SLC22A23 SLC22A12
SLC22A16 SLC22A7 SLC22A13 SLC22A3 SLC22A1 SLC22A2
SLC22A10 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SLC22A10
PGOHUM00000258594 PGOHUM00000249499
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Genomic Variants
for SLC22A10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC22A10 (62905339 - 63137190 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC22A10
1 CNV: 2930 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC22A10 |
|
Disorders
/ Diseases
for SLC22A10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC22A10 for disorders About GeneDecksing
OMIM gene information: 607580
OMIM disorders: --
4  diseases for SLC22A10: About MalaCardsrenovascular hypertension intrahepatic cholangiocarcinoma cholangiocarcinoma hypertension
Export disorders for SLC22A10 gene to outside databases
|
Publications
for SLC22A10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC22A10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC22A10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of a family of organic anion transporters from human liver and kidney. (PubMed id 11327718)1, 2, 3 Sun W.... Erion M.D. (2001)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PubMed id 12372408)1, 2 Eraly S.A. and Nigam S.K. (2002)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. (PubMed id 15068970)7 Youngblood G.L. and Sweet D.H. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SLC22A10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLC22A10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC22A10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC22A10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC22A10 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC22A10 gene:
Search GeneIP for patents involving SLC22A10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC22A10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC22A10 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC22A10 | | OriGene 3'-UTR Clone for SLC22A10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC22A10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | SLC22A10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC22A10 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC22A10 |
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