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Aliases for SLC22A10 Gene

Aliases for SLC22A10 Gene

  • Solute Carrier Family 22 Member 10 2 3 5
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 10 2 3
  • Organic Anion Transporter 5 3 4
  • OAT5 3 4
  • Solute Carrier Family 22, Member 10 2
  • HOAT5 3

External Ids for SLC22A10 Gene

Previous GeneCards Identifiers for SLC22A10 Gene

  • GC11U990606
  • GC11P062815
  • GC11P059386
  • GC11P062905

Summaries for SLC22A10 Gene

GeneCards Summary for SLC22A10 Gene

SLC22A10 (Solute Carrier Family 22 Member 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SLC22A25.

Gene Wiki entry for SLC22A10 Gene

Additional gene information for SLC22A10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A10 Gene

Genomics for SLC22A10 Gene

GeneHancer (GH) Regulatory Elements for SLC22A10 Gene

Promoters and enhancers for SLC22A10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I063290 Promoter 0.6 EPDnew 550.1 +152.3 152329 0.1 ZGPAT SLC22A10 ENSG00000256181 SLC22A9
GH11I063243 Enhancer 0.7 FANTOM5 38.7 +105.9 105864 0.7 RXRA TAF1 MAX REST YY1 JUND ATF3 HNF4A SLC22A25 CCND2P1 SLC22A10 SLC22A9 SLC22A24 LOC105369334
GH11I063249 Enhancer 0.9 dbSUPER 8.8 +113.0 113040 2.8 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 RXRA SP5 NFYC MXD4 LOC105369334 SLC22A10 SLC22A25
GH11I063144 Promoter 0.5 EPDnew 0.4 +6.4 6392 0.1 SLC22A24 SLC22A10 GC11M063173
GH11I063240 Enhancer 1.1 ENCODE dbSUPER 0.1 +103.0 102977 0.2 ELF3 FOXA2 ARID4B RAD21 THRB ZSCAN9 RARA SLC30A9 SMARCC2 FOS ENSG00000256863 SNHG1 CCND2P1 SLC22A25 SLC22A10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC22A10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC22A10 gene promoter:

Genomic Locations for SLC22A10 Gene

Genomic Locations for SLC22A10 Gene
chr11:63,137,867-63,369,718
(GRCh38/hg38)
Size:
231,852 bases
Orientation:
Plus strand
chr11:62,905,339-63,137,190
(GRCh37/hg19)

Genomic View for SLC22A10 Gene

Genes around SLC22A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A10 Gene

Proteins for SLC22A10 Gene

  • Protein details for SLC22A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63ZE4-S22AA_HUMAN
    Recommended name:
    Solute carrier family 22 member 10
    Protein Accession:
    Q63ZE4
    Secondary Accessions:
    • Q68CJ0

    Protein attributes for SLC22A10 Gene

    Size:
    541 amino acids
    Molecular mass:
    60257 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC22A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A10 Gene

Post-translational modifications for SLC22A10 Gene

  • Glycosylation at posLast=5656 and isoforms=102

No data available for DME Specific Peptides for SLC22A10 Gene

Domains & Families for SLC22A10 Gene

Gene Families for SLC22A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC22A10 Gene

Suggested Antigen Peptide Sequences for SLC22A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q63ZE4

UniProtKB/Swiss-Prot:

S22AA_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A10: view

Function for SLC22A10 Gene

Gene Ontology (GO) - Molecular Function for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005452 inorganic anion exchanger activity IBA --
GO:0015143 urate transmembrane transporter activity IBA --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC22A10: view
genes like me logo Genes that share phenotypes with SLC22A10: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A10 Gene

Localization for SLC22A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC22A10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC22A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC22A10 Gene

Pathways & Interactions for SLC22A10 Gene

SuperPathways for SLC22A10 Gene

No Data Available

Interacting Proteins for SLC22A10 Gene

Gene Ontology (GO) - Biological Process for SLC22A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0015747 urate transport IBA --
GO:0043252 sodium-independent organic anion transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC22A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC22A10 Gene

Drugs & Compounds for SLC22A10 Gene

(4) Drugs for SLC22A10 Gene - From: DrugBank and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
conjugated estrogens Approved Pharma Transporter, inhibitor 0
Probenecid Approved, Investigational Pharma Inhibition, Inhibitor, Transporter, inhibitor 35
Salicylic acid Approved, Investigational, Vet_approved Pharma Channel blocker, Transporter, inhibitor 212
Premarin Approved July of 2003 Pharma 0
genes like me logo Genes that share compounds with SLC22A10: view

Transcripts for SLC22A10 Gene

Unigene Clusters for SLC22A10 Gene

Solute carrier family 22, member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:

Relevant External Links for SLC22A10 Gene

GeneLoc Exon Structure for
SLC22A10
ECgene alternative splicing isoforms for
SLC22A10

Expression for SLC22A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC22A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC22A10 Gene

This gene is overexpressed in Liver (x43.0).

Protein differential expression in normal tissues from HIPED for SLC22A10 Gene

This gene is overexpressed in CD8 Tcells (45.7) and NK cells (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A10 Gene



Protein tissue co-expression partners for SLC22A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC22A10 Gene:

SLC22A10

SOURCE GeneReport for Unigene cluster for SLC22A10 Gene:

Hs.188982

mRNA Expression by UniProt/SwissProt for SLC22A10 Gene:

Q63ZE4-S22AA_HUMAN
Tissue specificity: Detected in fetal and adult liver, and in adult kidney.

Evidence on tissue expression from TISSUES for SLC22A10 Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with SLC22A10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC22A10 Gene

Orthologs for SLC22A10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLC22A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A10 33 34
  • 94.72 (n)
dog
(Canis familiaris)
Mammalia SLC22A10 33 34
  • 79.75 (n)
cow
(Bos Taurus)
Mammalia LOC522784 33
  • 79.31 (n)
-- 34
  • 67 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 42 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Slc22a22 34
  • 38 (a)
ManyToMany
Species where no ortholog for SLC22A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC22A10 Gene

ENSEMBL:
Gene Tree for SLC22A10 (if available)
TreeFam:
Gene Tree for SLC22A10 (if available)

Paralogs for SLC22A10 Gene

Pseudogenes.org Pseudogenes for SLC22A10 Gene

genes like me logo Genes that share paralogs with SLC22A10: view

Variants for SLC22A10 Gene

Sequence variations from dbSNP and Humsavar for SLC22A10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000017286 -- 63,308,558(+) A/C/G genic_downstream_transcript_variant, intron_variant
rs1000123727 -- 63,303,215(+) T/A intron_variant
rs1000130096 -- 63,267,525(+) T/C upstream_transcript_variant
rs1000237909 -- 63,297,024(+) A/G intron_variant
rs1000269391 -- 63,288,775(+) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC22A10 Gene

Variant ID Type Subtype PubMed ID
esv2759833 CNV loss 17122850
nsv507596 OTHER sequence alteration 20534489
nsv555177 CNV loss 21841781
nsv555178 CNV gain 21841781

Variation tolerance for SLC22A10 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.47; 99.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC22A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC22A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A10 Gene

Disorders for SLC22A10 Gene

Additional Disease Information for SLC22A10

No disorders were found for SLC22A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC22A10 Gene

Publications for SLC22A10 Gene

  1. Isolation of a family of organic anion transporters from human liver and kidney. (PMID: 11327718) Sun W … Erion MD (Biochemical and biophysical research communications 2001) 2 3 4 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  3. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. (PMID: 12372408) Eraly SA … Nigam SK (Biochemical and biophysical research communications 2002) 3 4 58
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3 58
  5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 4 58

Products for SLC22A10 Gene

Sources for SLC22A10 Gene

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