Aliases for SLC20A2 Gene
External Ids for SLC20A2 Gene
Previous HGNC Symbols for SLC20A2 Gene
Previous GeneCards Identifiers for SLC20A2 Gene
This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for SLC20A2 Gene
SLC20A2 (Solute Carrier Family 20 (Phosphate Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC20A2 include primary familial brain calcification 1 and primary familial brain calcification 3. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor activity and sodium:phosphate symporter activity. An important paralog of this gene is SLC20A1.
UniProtKB/Swiss-Prot for SLC20A2 Gene
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.