Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC20A1 Gene

protein-coding   GIFtS: 60
GCID: GC02P113403

solute carrier family 20 (phosphate transporter), member...


(Previous symbol: GLVR1)
 Explore 18 diseases affiliated with
SLC20A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC20A1    

Aliases
for SLC20A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 20 (Phosphate Transporter), Member 11 2     Solute Carrier Family 20 Member 12 3
GLVR11 2 3 5     PIT12 3
PiT-11 2 3     Sodium-Dependent Phosphate Transporter 12
Glvr-11 2     GLVR-13
Gibbon Ape Leukemia Virus Receptor 12 3     Phosphate Transporter 13
Leukemia Virus Receptor 1 Homolog2 3     

External Ids:    HGNC: 109461   Entrez Gene: 65742   Ensembl: ENSG000001441367   OMIM: 1375705   UniProtKB: Q8WUM93   

Export aliases for SLC20A1 gene to outside databases

Previous GC identifers: GC02P110609 GC02P111324 GC02P113310 GC02P113498 GC02P113119 GC02P105859


Summaries
for SLC20A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC20A1:
The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use
in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded
protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia
virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.(provided by
RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: S20A1_HUMAN, Q8WUM9
Function: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as
absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal
transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage
calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells
susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline
leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV)

Gene Wiki entry for SLC20A1


Genomic Views
for SLC20A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC20A1 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   POU3F2 (N-Oct-5b)   E2F-2   E47   E2F   E2F-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC20A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC20A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC20A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q13

SLC20A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC20A1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113403:  view genomic region     (about GC identifiers)

Start:
 113,403,434 bp from pter      End:
 113,421,404 bp from pter
Size:
 17,971 bases      Orientation:
 plus strand

Proteins
for SLC20A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S20A1_HUMAN, Q8WUM9 (See protein sequence)
Recommended Name: Sodium-dependent phosphate transporter 1  
Size: 679 amino acids; 73700 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q08344 Q6DHX8 Q9UQ82

Explore the universe of human proteins at neXtProt for SLC20A1: NX_Q8WUM9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WUM9

    • SLC20A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005406.3  
    ENSEMBL proteins: 
     ENSP00000272542   ENSP00000392050   ENSP00000390021   ENSP00000403763   ENSP00000413393  
    Reactome Protein details: Q8WUM9
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SLC20A1 
    GenScript Custom Purified and Recombinant Proteins Services for SLC20A1
    Novus Biologicals SLC20A1 Protein
    Novus Biologicals SLC20A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC20A1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8041748
    GO:0016020membrane TAS8041748
    GO:0016021integral to membrane ----


    SLC20A1 for ontologies           About GeneDecksing



    SLC20A1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC20A1 
    GenScript Custom Superior Antibodies Services for SLC20A1
    Novus Biologicals SLC20A1 Antibodies
    Search for Antibodies for SLC20A1 at Abcam  
    Uscn Antibodies for SLC20A1
    Search ThermoFisher Antibodies for SLC20A1

    Assay Products for SLC20A1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC20A1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLC20A1

    Protein Domains /
    Families
    for SLC20A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC20A1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001204 Phos_transporter

    Graphical View of Domain Structure for InterPro Entry Q8WUM9

    ProtoNet protein and cluster: Q8WUM9

    1 Blocks protein family: IPB001204 Phosphate transporter

    UniProtKB/Swiss-Prot: S20A1_HUMAN, Q8WUM9
    Domain: Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline
    leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents
    viral infection
    Similarity: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family


    Function
    for SLC20A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S20A1_HUMAN, Q8WUM9
    Function: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as
    absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal
    transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage
    calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells
    susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline
    leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV)
    Biophysicochemical properties: Kinetic parameters: KM=24.1 uM for phosphate; Vmax=1.9 nmol/min/mg enzyme (in the
    presence of 0.05-2 mM phosphate); Note=With an increase in pH, a decrease in phosphate uptake is observed; pH
    dependence: Optimum pH is 6.5 and 7.5;
    Induction: By phosphate deprivation as well as by IL8/interleukin-8 in hypertrophic chondrocytes

         Genatlas biochemistry entry for SLC20A1:
    solute carrier family 20,member 1 (phosphate transport),putatively involved in the regulation of Pi handling in bone
    forming cells

    miRNA
    Products:            		miRTarBase miRNAs that target SLC20A1:
    hsa-mir-98 (MIRT004945), hsa-let-7a (MIRT004960)

    OriGene 3'-UTR Clone: SLC20A1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC20A1
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC20A1 (see all 31):
    hsa-let-7d hsa-miR-539 hsa-miR-513a-5p hsa-miR-200a hsa-let-7a-2* hsa-let-7c hsa-miR-4299 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: SLC20A1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC20A1 (see all 7)
    OriGene shRNA RFP: SLC20A1
    OriGene siRNA: SLC20A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC20A1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC20A1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC20A1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC20A1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC20A1 (NM_005415)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC20A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC20A1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SLC20A1
    Search LifeMap BioReagents cell lines for SLC20A1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC20A1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0004872receptor activity TAS8041748
    GO:0005315inorganic phosphate transmembrane transporter activity IEA--
    GO:0005316high affinity inorganic phosphate:sodium symporter activity IEA--
    GO:0005436sodium:phosphate symporter activity TAS8041748


    SLC20A1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SLC20A1:
     Decreased viability of wild-ty  Increased S DNA content  Lamellipodia cells 

    Animal Models:
         Mouse knock-outs for SLC20A1: Slc20a1tm1.2Cmg Slc20a1tm1.2Lbek
         12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Slc20a1):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     normal  skeleton 

    SLC20A1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC20A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    2Type II Na+/Pi cotransporters
    		Sodium-coupled phosphate cotransporters0.60
    3Amino acid and oligopeptide SLC transporters
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC20A1
        Sodium-coupled phosphate cotransporters
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides



    SLC20A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC20A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/14 Interacting proteins for SLC20A1 (Q8WUM93 ENSP000002725424) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP3D1O146173, ENSP000003440554I2D: score=1 STRING: ENSP00000344055
    LMBR1LQ6UX013I2D: score=5 
    PIGTQ969N23I2D: score=5 
    RPS3P233963I2D: score=5 
    ALLCQ8N6M53I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006796phosphate-containing compound metabolic process TAS8041748
    GO:0006810transport TAS8041748
    GO:0006811ion transport TAS--
    GO:0006814sodium ion transport ----
    GO:0006817phosphate ion transport ----


    SLC20A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC20A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC20A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC20A1

    2 HMDB Compounds for SLC20A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    SodiumSodium (see all 2)7440-23-5--
    3 Novoseek chemical compound relationships for SLC20A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    foscarnet 78.2 1 16734382 (1)
    calcium 19.4 7 17989650 (1), 17565274 (1), 15569318 (1), 19546357 (1)
    arginine 0 1 11602698 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC20A1 / S20A1 

    Transcripts
    for SLC20A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC20A1 gene: 
    NM_005415.4  

    Unigene Cluster for SLC20A1:

    Solute carrier family 20 (phosphate transporter), member 1
    Hs.187946  [show with all ESTs]
    Unigene Representative Sequence: NM_005415
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272542(uc002tic.1 uc002tib.3) ENST00000423633 ENST00000498224
    ENST00000433924 ENST00000456264 ENST00000413135 ENST00000480984 ENST00000492076
    ENST00000490674

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SLC20A1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC20A1
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC20A1 (see all 31):
    hsa-let-7d hsa-miR-539 hsa-miR-513a-5p hsa-miR-200a hsa-let-7a-2* hsa-let-7c hsa-miR-4299 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: SLC20A1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC20A1 (see all 7)
    OriGene shRNA RFP: SLC20A1
    OriGene siRNA: SLC20A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC20A1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC20A1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC20A1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLC20A1 (NM_005415)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC20A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC20A1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC20A1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC20A1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC20A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC20A1

    Additional cDNA sequence: 

    AK123420.1 AK312738.1 BC019944.1 BC075818.1 BX647555.1 L20859.1 

    15 DOTS entries:

    DT.97780721  DT.95362319  DT.117410  DT.95182976  DT.410647  DT.101957042  DT.100728454  DT.100878559 
    DT.91752393  DT.95182974  DT.95182981  DT.100657856  DT.120990515  DT.86837161  DT.95182975 

    24/347 AceView cDNA sequences (see all 347):

    W94946 BU191696 BU162106 CA489590 BI868928 BU156557 BP344638 BQ049281 
    CB126268 R93390 CF272436 BX955672 AW009358 AI288450 BM543157 AI582830 
    AL599516 AI565089 BU957394 CB130249 CR619726 BX418386 AU105562 BQ950013 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SLC20A1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -                 -           -     -     -           -                                                         
    SP2:                                                  -                 -     -           -                                                         
    SP3:              -     -     -     -                 -           -     -     -     -     -                                                         
    SP4:                                                  -           -     -     -           -                                                         
    SP5:                                                  -           -     -     -           -     -                                                   


    ECgene alternative splicing isoforms for SLC20A1

    Expression
    for SLC20A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC20A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCATTTGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC20A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BrainCerebral CortexBrain
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See SLC20A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC20A1

    SOURCE GeneReport for Unigene cluster: Hs.187946

    UniProtKB/Swiss-Prot: S20A1_HUMAN, Q8WUM9
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for SLC20A1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC20A1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC20A1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC20A1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC20A1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC20A1

    Orthologs
    for SLC20A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC20A1 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC20A11 solute carrier family 20 (phosphate transporter), member more 74.95(n)
    85.03(a)    		   426250  XM_003642557.1  XP_003642605.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC684962 hypothetical protein MGC68496 79.16(n)    BC059957.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa05g122 Danio rerio cDNA clone MGC66257 IMAGE3820608, complete more 76.92(n)    BC057497.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG76283 phosphate transporter 53(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea C48A7.21 , 3 phosphate permease3
    Protein C48A7.21    		 57(a)
    (best of 5)3
    54.84(n)1
    50.99(a)1    		   IV(7394285-7396914)3
    1775121  NM_068779.31  NP_501180.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PHT2;16
    		 inorganic phosphate transporter 2-1
    		 23(a)
    		 possible ortholog
    		 3(9756191-9758633)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 inorganic phosphate transporter 2-1, chloroplast p...
    		 27(a)
    		 possible ortholog
    		 2(22965694-22969427)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria pitA6
    pitB6
    		 phosphate transporter
    		 16(a)
    16(a)
    		 possible ortholog
    possible ortholog
    		 Chromosome(3635665-3637164)
    Chromosome(3132894-3134393)


    ENSEMBL Gene Tree for SLC20A1 (if available)
    TreeFam Gene Tree for SLC20A1 (if available) 

    Paralogs
    for SLC20A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC20A1 gene
    SLC20A22  
    1 SIMAP similar gene for SLC20A1 using alignment to 6 protein entries:     S20A1_HUMAN (see all proteins):
    SLC20A2

    SLC20A1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SLC20A1
    PGOHUM00000262892 PGOHUM00000247980 PGOHUM00000246612


    Genomic Variants
    for SLC20A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/384 NCBI SNPs in SLC20A1 are shown (see all 384)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs124696751,2
    		C,F,H,--105856245(+) TCAGAT/GGAATC 1 -- us2k14Minor allele frequency- G:0.10NA 128
    rs571022141,2
    		--105856723(+) CGTCTC/TTGTTT 1 -- us2k10--------
    rs75610841,2
    		A,H--105857164(+) CAGCCT/ACTGTT 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs751904861,2
    		C,--105857272(+) CCCCTC/GGCAAC 1 -- us2k12Minor allele frequency- G:0.02NA 122
    rs75585891,2
    		A--105857450(+) CCCCCA/CCCCCC 1 -- us2k1 tfbs30--------
    rs1130247241,2
    		C--105858145(+) ACCCGT/GGNNNN 1 -- ut511Minor allele frequency- G:0.00CSA 1
    rs791456671,2
    		F,--105858842(+) TTTTTG/AATACC 1 -- ut511Minor allele frequency- A:0.10WA 118
    rs1144703061,2
    		C,F,--105861103(+) GGTAAA/GGGTTT 1 -- int11Minor allele frequency- G:0.04WA 118
    rs772230341,2
    		F,--105861220(+) TGCTCT/GGAGGT 1 -- int11Minor allele frequency- G:0.03WA 118
    rs170422071,2
    		C,--105861500(+) TATGAA/CTATTT 1 -- int14Minor allele frequency- C:0.01NA 144

    HapMap Linkage Disequilibrium report for SLC20A1 (113403434 - 113421404 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC20A1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC20A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC20A1

    Disorders / Diseases
    for SLC20A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC20A1 for disorders           About GeneDecksing

    OMIM gene information: 137570    OMIM disorders: --

    18 diseases for SLC20A1:    About MalaCards
    leukemia    isolated growth hormone deficiency    growth hormone deficiency    sarcoma
    hyperphosphatemia    secondary hyperparathyroidism    chronic lymphocytic leukemia    lymphocytic leukemia
    werner syndrome    hyperparathyroidism    hemophilia    hemochromatosis
    breast cancer    hypertension    hypoxia    tuberculosis
    malaria    mycobacterium tuberculosis

    5 Novoseek disease relationships for SLC20A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperphosphatemia 78.5 2 16384827 (2)
    leukemia feline 75.7 7 11435563 (2), 9343161 (1), 8411376 (1), 19717569 (1)
    calcification 61.2 20 16527991 (5), 17565274 (3), 19655218 (3), 18179800 (2) (see all 9)
    leukemia 60.1 21 9271190 (2), 10933951 (1), 9454686 (1), 9853528 (1) (see all 14)
    tumors 0 2 12362974 (1), 17565274 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC20A1 (7 documents)

    Export disorders for SLC20A1 gene to outside databases

    Publications
    for SLC20A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC20A1 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with SLC20A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. (PubMed id 8041748)1, 2, 3 Kavanaugh M.P....Miller A.D. (1994)
    2. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. (PubMed id 15641067)1, 2, 9 Cecil D.L.... Liu-Bryan R. (2005)
    3. GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. (PubMed id 1531369)1, 2, 9 Johann S.V.... O'Hara B. (1992)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Reassessing the role of region A in Pit1-mediated viral entry. (PubMed id 12097582)1, 2 Farrell K.B.... Eiden M.V. (2002)
    7. Phosphate regulation of vascular smooth muscle cell calcification. (PubMed id 11009570)1, 2 Jono S.... Giachelli C.M. (2000)
    8. Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region. (PubMed id 9889306)1, 2 Palmer G.... Caverzasio J. (1999)
    9. A family of retroviruses that utilize related phosphate transporters for cell entry. (PubMed id 7966619)1, 2 Miller D.G. and Miller A.D. (1994)
    10. The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter. (PubMed id 7929240)1, 2 Olah Z.... Wilson C.A. (1994)

    External Searches for SLC20A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC20A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6574 HGNC: 10946 AceView: SLC20A1 Ensembl:ENSG00000144136 euGenes: HUgn6574
    ECgene: SLC20A1 H-InvDB: SLC20A1

    Other Databases showing SLC20A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC20A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC20A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC20A1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SLC20A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC20A1 gene:
    Search GeneIP for patents involving SLC20A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SLC20A1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SLC20A1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC20A1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC20A1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SLC20A1   OriGene 3'-UTR Clone for SLC20A1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC20A1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC20A1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC20A1   OriGene Custom Protein Services for SLC20A1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC20A1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC20A1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC20A1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC20A1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC20A1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC20A1
     GenScript Custom Purified and Recombinant Proteins Services for SLC20A1 GenScript cDNA clones with any tag delivered in your preferred vector for SLC20A1
     GenScript Custom Assay Services for SLC20A1 GenScript Custom Superior Antibodies Services for SLC20A1
     GenScript Custom overexpressing Cell Line Services for SLC20A1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC20A1 promoter
     Search Chromatin IP Primers for SLC20A1
     RT2 qPCR Primer Assay in human, mouse, rat SLC20A1
     Search GNC Networks for SLC20A1
     SABiosciences Custom PCR Arrays for SLC20A1
     Search Tocris compounds for SLC20A1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC20A1 antibodies
     SLC20A1 proteins
     SLC20A1 lysates
     Search for Antibodies for SLC20A1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC20A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SLC20A1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SLC20A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC20A1
     SwitchGear 3'UTR luciferase reporter plasmids for SLC20A1
     SwitchGear Promoter luciferase reporter plasmids for SLC20A1
     Search ThermoFisher Antibodies for SLC20A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC20A1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SLC20A1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4