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Aliases for SLC20A1 Gene

Aliases for SLC20A1 Gene

  • Solute Carrier Family 20 (Phosphate Transporter), Member 1 2 3
  • Gibbon Ape Leukemia Virus Receptor 1 2 3 4
  • GLVR1 3 4 6
  • Leukemia Virus Receptor 1 Homolog 3 4
  • Solute Carrier Family 20 Member 1 3 4
  • Glvr-1 3 4
  • PiT-1 3 4
  • PIT1 3 4
  • Sodium-Dependent Phosphate Transporter 1 3
  • Phosphate Transporter 1 4

External Ids for SLC20A1 Gene

Previous Symbols for SLC20A1 Gene

  • GLVR1

Summaries for SLC20A1 Gene

Entrez Gene Summary for SLC20A1 Gene

  • The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]

GeneCards Summary for SLC20A1 Gene

SLC20A1 (Solute Carrier Family 20 (Phosphate Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC20A1 include leukemia and isolated growth hormone deficiency. Among its related pathways are Glucose / Energy Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include signal transducer activity and sodium:phosphate symporter activity. An important paralog of this gene is SLC20A2.

UniProtKB/Swiss-Prot for SLC20A1 Gene

  • Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).

Gene Wiki entry for SLC20A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC20A1 Gene

Genomics for SLC20A1 Gene

Genomic Location for SLC20A1 Gene

Start:
112,645,857 bp from pter
End:
112,663,827 bp from pter
Size:
17,971 bases
Orientation:
Plus strand

Genomic View for SLC20A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC20A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC20A1 Gene

Regulatory Elements for SLC20A1 Gene

Proteins for SLC20A1 Gene

  • Protein details for SLC20A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUM9-S20A1_HUMAN
    Recommended name:
    Sodium-dependent phosphate transporter 1
    Protein Accession:
    Q8WUM9
    Secondary Accessions:
    • Q08344
    • Q6DHX8
    • Q9UQ82

    Protein attributes for SLC20A1 Gene

    Size:
    679 amino acids
    Molecular mass:
    73700 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC20A1 Gene

Proteomics data for SLC20A1 Gene at MOPED

Post-translational modifications for SLC20A1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys389 and Lys394

Other Protein References for SLC20A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC20A1 Gene

Domains for SLC20A1 Gene

Gene Families for SLC20A1 Gene

Protein Domains for SLC20A1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

S20A1_HUMAN
Domain:
  • Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection:
    • Q8WUM9
Family:
  • Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.:
    • Q8WUM9
genes like me logo Genes that share domains with SLC20A1: view

Function for SLC20A1 Gene

Molecular function for SLC20A1 Gene

GENATLAS Biochemistry: solute carrier family 20,member 1 (phosphate transport),putatively involved in the regulation of Pi handling in bone forming cells
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=24.1 uM for phosphate {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748}; Vmax=1.9 nmol/min/mg enzyme (in the presence of 0.05-2 mM phosphate) {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748}; Note=With an increase in pH, a decrease in phosphate uptake is observed.; pH dependence: Optimum pH is 6.5 and 7.5. {ECO:0000269 PubMed:7929240, ECO:0000269 PubMed:8041748};
UniProtKB/Swiss-Prot Function: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).
UniProtKB/Swiss-Prot Induction: By phosphate deprivation as well as by IL8/interleukin-8 in hypertrophic chondrocytes.

Gene Ontology (GO) - Molecular Function for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0004872 receptor activity TAS 8041748
GO:0005315 inorganic phosphate transmembrane transporter activity IEA --
GO:0005316 high-affinity inorganic phosphate:sodium symporter activity IEA --
GO:0005436 sodium:phosphate symporter activity TAS 8041748
genes like me logo Genes that share ontologies with SLC20A1: view
genes like me logo Genes that share phenotypes with SLC20A1: view

Animal Models for SLC20A1 Gene

MGI Knock Outs for SLC20A1:

miRNA for SLC20A1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC20A1 Gene

Localization for SLC20A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC20A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC20A1 Gene COMPARTMENTS Subcellular localization image for SLC20A1 gene
Compartment Confidence
plasma membrane 4
chloroplast 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8041748
GO:0016020 membrane TAS 8041748
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC20A1: view

Pathways for SLC20A1 Gene

genes like me logo Genes that share pathways with SLC20A1: view

Gene Ontology (GO) - Biological Process for SLC20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 8041748
GO:0006810 transport TAS 8041748
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport --
GO:0006817 phosphate ion transport --
genes like me logo Genes that share ontologies with SLC20A1: view

Compounds for SLC20A1 Gene

(2) HMDB Compounds for SLC20A1 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Sodium
  • Sodium
7440-23-5

(3) Novoseek inferred chemical compound relationships for SLC20A1 Gene

Compound -log(P) Hits PubMed IDs
foscarnet 78.2 1
calcium 19.4 4
arginine 0 1
genes like me logo Genes that share compounds with SLC20A1: view

Transcripts for SLC20A1 Gene

Unigene Clusters for SLC20A1 Gene

Solute carrier family 20 (phosphate transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC20A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6:
SP7: -
SP8: - - - - - -
SP9:
SP10:

Relevant External Links for SLC20A1 Gene

GeneLoc Exon Structure for
SLC20A1
ECgene alternative splicing isoforms for
SLC20A1

Expression for SLC20A1 Gene

mRNA expression in normal human tissues for SLC20A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC20A1 Gene

SOURCE GeneReport for Unigene cluster for SLC20A1 Gene Hs.187946

mRNA Expression by UniProt/SwissProt for SLC20A1 Gene

Q8WUM9-S20A1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SLC20A1: view

Orthologs for SLC20A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC20A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC20A1 36
  • 99.61 (n)
  • 99.41 (a)
SLC20A1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC20A1 36
  • 90.05 (n)
  • 95.57 (a)
SLC20A1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC20A1 36
  • 92.77 (n)
  • 96.02 (a)
SLC20A1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc20a1 36
  • 89.63 (n)
  • 92.87 (a)
Slc20a1 16
Slc20a1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC20A1 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC20A1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc20a1 36
  • 89.48 (n)
  • 92.87 (a)
chicken
(Gallus gallus)
Aves SLC20A1 36
  • 75.08 (n)
  • 85.64 (a)
SLC20A1 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68496 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc20a1 36
  • 74.11 (n)
  • 80.74 (a)
Str.10938 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5974 36
zebrafish
(Danio rerio)
Actinopterygii slc20a1a 37
  • 64 (a)
OneToMany
slc20a1b 36
  • 66.93 (n)
  • 73.25 (a)
slc20a1b 37
  • 69 (a)
OneToMany
wufa05g12 36
fruit fly
(Drosophila melanogaster)
Insecta CG42575 37
  • 37 (a)
OneToMany
CG7628 38
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea C48A7.2 36
  • 53.57 (n)
  • 49.21 (a)
pitr-1 37
  • 40 (a)
ManyToMany
pitr-2 37
  • 42 (a)
ManyToMany
pitr-3 37
  • 44 (a)
ManyToMany
pitr-4 37
  • 30 (a)
ManyToMany
pitr-5 37
  • 41 (a)
ManyToMany
pitr-6 37
  • 34 (a)
ManyToMany
C48A7.2 38
  • 57 (a)
W05H5.3 38
  • 37 (a)
F09G2.3 38
  • 43 (a)
B0222.3 38
  • 42 (a)
B0222.2 38
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO89 37
  • 29 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.4001 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2670 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
ManyToMany
-- 37
  • 56 (a)
ManyToMany
CSA.3671 37
  • 43 (a)
ManyToMany
Species with no ortholog for SLC20A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SLC20A1 Gene

ENSEMBL:
Gene Tree for SLC20A1 (if available)
TreeFam:
Gene Tree for SLC20A1 (if available)

Paralogs for SLC20A1 Gene

Paralogs for SLC20A1 Gene

Selected SIMAP similar genes for SLC20A1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SLC20A1 Gene

genes like me logo Genes that share paralogs with SLC20A1: view

Variants for SLC20A1 Gene

Sequence variations from dbSNP and Humsavar for SLC20A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6793 -- 112,663,757(+) GTTAA(A/G)TGGGA utr-variant-3-prime
rs10141 -- 112,663,619(+) TTTTT(C/T)GCAAG utr-variant-3-prime
rs10758 -- 112,652,438(+) TTGCA(A/G)TCTTT intron-variant
rs885346 -- 112,657,973(-) TTCAA(A/C)TTGCT intron-variant
rs885347 -- 112,657,779(-) ATGTG(C/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC20A1 Gene

Variant ID Type Subtype PubMed ID
nsv458997 CNV Gain 19166990
nsv470480 CNV Gain 18288195

Relevant External Links for SLC20A1 Gene

HapMap Linkage Disequilibrium report
SLC20A1

Disorders for SLC20A1 Gene

(5) Novoseek inferred disease relationships for SLC20A1 Gene

Disease -log(P) Hits PubMed IDs
hyperphosphatemia 78.5 2
leukemia feline 75.7 5
calcification 61.2 19
leukemia 60.1 15
tumors 0 2

Relevant External Links for SLC20A1

Genetic Association Database (GAD)
SLC20A1
Human Genome Epidemiology (HuGE) Navigator
SLC20A1
genes like me logo Genes that share disorders with SLC20A1: view

No data available for UniProtKB/Swiss-Prot for SLC20A1 Gene

Publications for SLC20A1 Gene

  1. GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. (PMID: 1531369) Johann S.V. … O'Hara B. (J. Virol. 1992) 3 4 23
  2. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. (PMID: 15641067) Cecil D.L. … Liu-Bryan R. (Arthritis Rheum. 2005) 3 4 23
  3. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. (PMID: 8041748) Kavanaugh M.P. … Miller A.D. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  4. Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species. (PMID: 8411375) Johann S.V. … O'Hara B. (J. Virol. 1993) 3 4
  5. Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks. (PMID: 17339538) Meyers K.J. … Kardia S.L. (Hypertension 2007) 3 49

Products for SLC20A1 Gene

Sources for SLC20A1 Gene

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