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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC1A7 Gene

protein-coding   GIFtS: 62
GCID: GC01M053552

Solute Carrier Family 1 (Glutamate Transporter), Member...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 1 (Glutamate Transporter), Member 71 2     AAAT2
Retinal Glutamate Transporter2 3     Excitatory Amino Acid Transporter 52
Solute Carrier Family 1 Member 72 3     Excitatory Amino Acid Transporter 5 (Retinal Glutamate Transporter)2
EAAT52 3     Excitatory Amino Acid Transporter 5a Long2

External Ids:    HGNC: 109451   Entrez Gene: 65122   Ensembl: ENSG000001623837   OMIM: 6044715   UniProtKB: O003413   

Export aliases for SLC1A7 gene to outside databases

Previous GC identifers: GC01M053188 GC01M052441 GC01M052911 GC01M052922 GC01M053264 GC01M053325 GC01M051668


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC1A7 Gene: 
SLC1A7 (solute carrier family 1 (glutamate transporter), member 7) is a protein-coding gene. Diseases associated with SLC1A7 include traumatic brain injury, and brain injury, and among its related super-pathways are Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell and Amino acid transport across the plasma membrane. GO annotations related to this gene include sodium:dicarboxylate symporter activity and L-glutamate transmembrane transporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot: EAA5_HUMAN, O00341
Function: Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and
chloride-independent. Its associated chloride conductance may participate in visual processing

summary for SLC1A7 Gene:
Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and
potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the
brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia),
EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low
ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for
metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated
in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia
and traumatic brain injury.

Gene Wiki entry for SLC1A7 (Excitatory amino-acid transporter 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC1A7 gene promoter:
         SRF   AML1a   SRF (504 AA)   Olf-1   STAT5A   Nkx2-5   POU2F1   POU2F1a   Chx10   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC1A7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC1A7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC1A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

SLC1A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC1A7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M053552:  view genomic region     (about GC identifiers)

Start:
53,552,855 bp from pter      End:
53,608,289 bp from pter
Size:
55,435 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EAA5_HUMAN, O00341 (See protein sequence)
Recommended Name: Excitatory amino acid transporter 5  
Size: 560 amino acids; 60658 Da
Subunit: Interacts with the PDZ domains of DLG4
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5VVZ0 Q969Z8

Explore the universe of human proteins at neXtProt for SLC1A7: NX_O00341

Explore proteomics data for SLC1A7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00341

  • SLC1A7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC1A7 Protein Expression
    REFSEQ proteins: NP_006662.3  
    ENSEMBL proteins: 
     ENSP00000360549   ENSP00000360546  
    Reactome Protein details: O00341
    Human Recombinant Protein Products for SLC1A7: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS--

    SLC1A7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Excitatory amino acid transporter 5 
    Glutamate transporter subfamily

    2 InterPro protein domains:
     IPR001991 Na-dicarboxylate_symporter
     IPR018107 Na-dicarboxylate_symporter_CS

    Graphical View of Domain Structure for InterPro Entry O00341

    ProtoNet protein and cluster: O00341

    1 Blocks protein domain: IPB001991 Sodium:dicarboxylate symporter

    UniProtKB/Swiss-Prot: EAA5_HUMAN, O00341
    Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A7 subfamily


    SLC1A7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EAA5_HUMAN, O00341
    Function: Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and
    chloride-independent. Its associated chloride conductance may participate in visual processing

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005313L-glutamate transmembrane transporter activity TAS9108121
    GO:0017153sodium:dicarboxylate symporter activity IEA--
         
    SLC1A7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC1A7:
     Increased S DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc1a7):
     behavior/neurological  homeostasis/metabolism 

    SLC1A7 for phenotypes           About GeneDecksing

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC1A7 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    2Amino acid and oligopeptide SLC transporters
    Amino acid and oligopeptide SLC transporters0.63
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    3SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    4GABA synthesis, release, reuptake and degradation
    Neurotransmitter Release Cycle0.53
    5Serotonin Neurotransmitter Release Cycle
    Glutamate Neurotransmitter Release Cycle0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for SLC1A7 (see all 8)
        Glutamate Neurotransmitter Release Cycle
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transmission across Chemical Synapses
    Amino acid and oligopeptide SLC transporters


    1         Kegg Pathway  (Kegg details for SLC1A7):
        Glutamatergic synapse


    SLC1A7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC1A7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SLC1A7 (O003413 ENSP000003605494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNTA1Q134243I2D: score=1 
    ZNF420ENSP000003387704STRING: ENSP00000338770
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0006835dicarboxylic acid transport TAS9108121
    GO:0015813L-glutamate transport TAS9108121
    GO:0055085transmembrane transport TAS--

    SLC1A7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC1A7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SLC1A7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TFB-TBOAHigh affinity EAAT1 and EAAT2 blocker[480439-73-4]
    DL-TBOASelective non-transportable inhibitor of EAATs[205309-81-5]
    L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor[64769-66-0]
    WAY 213613 Potent, non-substrate EAAT2 inhibitor [868359-05-1]
    Dihydrokainic acidEAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake[52497-36-6]

    2 HMDB Compounds for SLC1A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC1A7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--15128272 9108121 17139284 17016423

    4 IUPHAR Ligands for SLC1A7 (Excitatory amino acid transporter 5)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]ETB-TBOA
    NoneNone7.5--
    DL-TBOA
    InhibitorInhibition5.511677257
    [3H]L-aspartic acid
    NoneNone5.5--
    [3H]D-aspartic acid
    NoneNone5.5--

    3 Novoseek inferred chemical compound relationships for SLC1A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 63.1 25 15468177 (4), 9108121 (3), 11006260 (2), 7702599 (1) (see all 11)
    chloride 39.2 4 9108121 (2)
    nmda 21.1 2 9108121 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC1A7 / EAA5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC1A7 gene: 
    NM_006671.4  

    Unigene Cluster for SLC1A7:

    Solute carrier family 1 (glutamate transporter), member 7
    Hs.104637  [show with all ESTs]
    Unigene Representative Sequence: AB593059
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371494(uc021onm.1 uc001cuy.3 uc021onn.1 uc021ono.1)
    ENST00000488036(uc001cux.3) ENST00000371491(uc001cuz.4)
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    Additional mRNA sequence: 

    AB593059.1 AB593060.1 AB593061.1 AK093921.1 AK094048.1 BC000651.2 BC012119.1 BC017242.2 
    JF917096.1 JX162773.1 U76362.1 

    7 DOTS entries:

    DT.40120632  DT.100020708  DT.92045377  DT.99930322  DT.95249742  DT.100662009  DT.92378851 

    24/47 AceView cDNA sequences (see all 47):

    CD672672 BM461613 BU727462 BM680033 BI905991 BU736781 BM799874 AA480366 
    BU187310 U76362 BC012119 BM804263 CF131219 BM682194 NM_006671 BG329647 
    BU189992 BG472897 AK093921 BG395207 BG470553 BC000651 BC017242 BQ434854 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                          -                             -           -                                       
    SP2:                                                                                                            
    SP3:                                                                    -                                       
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SLC1A7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC1A7 expression in normal human tissues (normalized intensities)      SLC1A7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATAGGTAG
    SLC1A7 Expression
    About this image


    SLC1A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Liver (Hepatobiliary System)
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   
     
     Mesenchymal Stem Cells
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   

    See SLC1A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC1A7

    SOURCE GeneReport for Unigene cluster: Hs.104637

    UniProtKB/Swiss-Prot: EAA5_HUMAN, O00341
    Tissue specificity: Expressed primarily in retina. Detectable in liver, heart, muscle and brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC1A7 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc1a71 , 5 solute carrier family 1 (glutamate transporter), member more1, 5 87.24(n)1
    92.49(a)1
      4 (50.18 cM)5
    2426071  NM_146255.21  NP_666367.21 
     1079683325 
    chicken
    (Gallus gallus)
    Aves SLC1A71 solute carrier family 1 (glutamate transporter), member more 74.19(n)
    84.66(a)
      429106  XM_426662.2  XP_426662.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC1A76
    Uncharacterized protein
    82(a)
    1 ↔ 1
    4(114939236-115019956)
    zebrafish
    (Danio rerio)
    Actinopterygii slc1a7a1 solute carrier family 1 (glutamate transporter), member more 72.11(n)
    75.32(a)
      100170783  NM_001130622.1  NP_001124094.1 


    ENSEMBL Gene Tree for SLC1A7 (if available)
    TreeFam Gene Tree for SLC1A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC1A7 gene
    SLC1A32  SLC1A52  SLC1A12  SLC1A22  SLC1A42  SLC1A62  
    6 SIMAP similar genes for SLC1A7 using alignment to 6 protein entries:     EAA5_HUMAN (see all proteins):
    SLC1A3    SLC1A6    SLC1A2    SLC1A1    SLC1A4    SLC1A5

    SLC1A7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1694 SNPs in SLC1A7 are shown (see all 1694)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357074
    A colorectal cancer sample4--see VAR_0357072 R C mis40--------
    rs774629271,2
    C,F--53552366(+) GGGCAC/TGCCCC 1 -- ds50011Minor allele frequency- T:0.07WA 118
    rs1876317741,2
    C--53552476(+) TAGACC/TATGGC 1 -- ds50010--------
    rs1909192011,2
    --53552712(+) GCCTGA/TTAGAT 1 -- ds50010--------
    rs1813682271,2
    C--53552879(+) ATTTAA/GTTAAC 1 -- ut310--------
    rs1859450711,2
    --53552945(+) GGCCTG/TTGGGG 1 -- ut310--------
    rs775204521,2
    C,F--53552985(+) TCCACC/TAGAGC 1 -- ut313Minor allele frequency- T:0.05CSA WA 122
    rs10477411,2
    C,F,H--53553069(-) AAAGGC/TCCCCT 1 -- ut31 ese318Minor allele frequency- T:0.23MN NS EA WA NA 2402
    rs1899689031,2
    C--53553447(+) TGTCAC/TAGCGG 1 -- ut310--------
    rs412985191,2
    F--53553450(+) CACAGC/TGGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC1A7 (53552855 - 53608289 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for SLC1A7 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672076CNV Deletion23128226
    esv2748163CNV Deletion23290073
    esv2748185CNV Deletion23290073
    esv2671978CNV Deletion23128226
    esv2743348CNV Deletion23290073
    dgv31e201CNV Deletion23290073
    esv2306191CNV Deletion18987734
    dgv43e199CNV Deletion23128226
    dgv42e199CNV Deletion23128226
    esv2748174CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604471    OMIM disorders: --

    11 diseases for SLC1A7:    About MalaCards
    traumatic brain injury    brain injury    ischemia    retinitis
    schizophrenia    hyperparathyroidism    neuronitis    retinoblastoma
    systemic lupus erythematosus    lupus erythematosus    tuberculosis


    SLC1A7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC1A7
    Human Genome Epidemiology (HuGE) Navigator: SLC1A7 (5 documents)

    Export disorders for SLC1A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC1A7 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with SLC1A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. (PubMed id 9108121)1, 2, 3, 7, 9 Arriza J.L.... Amara S.G. (1997)
    2. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PubMed id 21408207)1, 4 Chung S.A....Criswell L.A. (2011)
    3. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    6. Multiple loci influencing hippocampal degeneration ide ntified by genome scan. (PubMed id 22745009)1 Melville S.A....Farrer L.A. (2012)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17362836)4 Schymick J.C....Traynor B.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6512 HGNC: 10945 AceView: SLC1A7 Ensembl:ENSG00000162383 euGenes: HUgn6512
    ECgene: SLC1A7 Kegg: 6512 H-InvDB: SLC1A7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC1A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC1A7 gene:
    Search GeneIP for patents involving SLC1A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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