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Aliases for SLC1A7 Gene

Aliases for SLC1A7 Gene

  • Solute Carrier Family 1 Member 7 2 3 4 5
  • Solute Carrier Family 1 (Glutamate Transporter), Member 7 2 3
  • Retinal Glutamate Transporter 3 4
  • EAAT5 3 4
  • Excitatory Amino Acid Transporter 5 (Retinal Glutamate Transporter) 3
  • Excitatory Amino Acid Transporter 5 3
  • AAAT 3

External Ids for SLC1A7 Gene

Previous GeneCards Identifiers for SLC1A7 Gene

  • GC01M053188
  • GC01M052441
  • GC01M052911
  • GC01M052922
  • GC01M053264
  • GC01M053325
  • GC01M053552
  • GC01M051668

Summaries for SLC1A7 Gene

GeneCards Summary for SLC1A7 Gene

SLC1A7 (Solute Carrier Family 1 Member 7) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include L-glutamate transmembrane transporter activity and sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A7 Gene

  • Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

Tocris Summary for SLC1A7 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.

Gene Wiki entry for SLC1A7 Gene

Additional gene information for SLC1A7 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A7 Gene

Genomics for SLC1A7 Gene

Regulatory Elements for SLC1A7 Gene

Enhancers for SLC1A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H053122 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 +19.6 19631 4 FOXA2 MLX ARID4B DMAP1 GLIS2 FOS SP5 MXD4 PPARG KAT8 PODN SLC1A7 LOC100190934 ENSG00000230953 PIR53839 GC01M053112
GH01H053132 1.3 Ensembl ENCODE dbSUPER 15.9 +8.3 8279 4 BCOR ZMYM3 CEBPG FOSL1 ZNF766 POLR2A ADNP ZNF584 MAFK SMARCA5 MAGOH NDC1 ENSG00000230953 PODN SLC1A7 LRRC42 ZCCHC11 RPS13P2 ECHDC2 PLA2G12AP1
GH01H053139 1.3 Ensembl ENCODE dbSUPER 15.8 +2.3 2332 1 BCOR ZNF175 ZMYM3 CEBPG FOSL1 CTBP1 ADNP FOS ZNF600 TRIM24 SLC1A7 PODN ZYG11A GC01P053132
GH01H053144 1.5 Ensembl ENCODE dbSUPER 13.4 -4.3 -4262 3 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 FOS ATF7 SP5 ZHX2 SLC1A7 PODN GPX7 PLA2G12AP1 LOC105378724
GH01H053089 1.4 Ensembl ENCODE dbSUPER 10.2 +52.8 52769 1 ELF3 MLX ARID4B RAD21 THRB ZSCAN9 RARA GLIS2 ATF7 CREM SLC1A7 ENSG00000235563 ENSG00000232993
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC1A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC1A7 Gene

Chromosome:
1
Start:
53,087,179 bp from pter
End:
53,142,632 bp from pter
Size:
55,454 bases
Orientation:
Minus strand

Genomic View for SLC1A7 Gene

Genes around SLC1A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A7 Gene

Proteins for SLC1A7 Gene

  • Protein details for SLC1A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00341-EAA5_HUMAN
    Recommended name:
    Excitatory amino acid transporter 5
    Protein Accession:
    O00341
    Secondary Accessions:
    • Q5VVZ0
    • Q969Z8
    • Q9BW45

    Protein attributes for SLC1A7 Gene

    Size:
    560 amino acids
    Molecular mass:
    60658 Da
    Quaternary structure:
    • Interacts with the PDZ domains of DLG4.

    Alternative splice isoforms for SLC1A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A7 Gene

Post-translational modifications for SLC1A7 Gene

  • Glycosylation at isoforms=191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC1A7 Gene

Domains & Families for SLC1A7 Gene

Gene Families for SLC1A7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC1A7 Gene

Graphical View of Domain Structure for InterPro Entry

O00341

UniProtKB/Swiss-Prot:

EAA5_HUMAN :
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily.
Family:
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily.
genes like me logo Genes that share domains with SLC1A7: view

Function for SLC1A7 Gene

Molecular function for SLC1A7 Gene

UniProtKB/Swiss-Prot Function:
Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

Phenotypes From GWAS Catalog for SLC1A7 Gene

Gene Ontology (GO) - Molecular Function for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS 9108121
GO:0005314 high-affinity glutamate transmembrane transporter activity TAS --
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC1A7: view
genes like me logo Genes that share phenotypes with SLC1A7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC1A7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC1A7 Gene

Localization for SLC1A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC1A7 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC1A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC1A7 Gene

Pathways & Interactions for SLC1A7 Gene

genes like me logo Genes that share pathways with SLC1A7: view

Interacting Proteins for SLC1A7 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360549%0d%0a9606.ENSP00000278379%0d%0a9606.ENSP00000318868%0d%0a9606.ENSP00000333667%0d%0a9606.ENSP00000311032%0d%0a9606.ENSP00000377617%0d%0a
Selected Interacting proteins: ENSP00000360549 O00341-EAA5_HUMAN for SLC1A7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport TAS 9108121
GO:0014047 glutamate secretion TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC1A7: view

No data available for SIGNOR curated interactions for SLC1A7 Gene

Drugs & Compounds for SLC1A7 Gene

(9) Drugs for SLC1A7 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 236
DL-TBOA Pharma Inhibition, Inhibitor inhibitor of excitatory amino acid transporters, Selective non-transportable inhibitor of EAATs 0
[<sup>3</sup>H]D-aspartic acid Pharma 0
[<sup>3</sup>H]L-aspartic acid Pharma 0
7-Chlorokynurenic acid sodium salt Pharma Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) 0

(5) Additional Compounds for SLC1A7 Gene - From: HMDB, IUPHAR, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]ETB-TBOA
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
sodium
  • Sodium
  • Sodium ion
7440-23-5

(5) Tocris Compounds for SLC1A7 Gene

Compound Action Cas Number
7-Chlorokynurenic acid sodium salt Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) 1263094-00-3
Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake 52497-36-6
DL-TBOA Selective non-transportable inhibitor of EAATs 205309-81-5
L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor 64769-66-0
TFB-TBOA High affinity EAAT1 and EAAT2 blocker 480439-73-4
genes like me logo Genes that share compounds with SLC1A7: view

Transcripts for SLC1A7 Gene

Unigene Clusters for SLC1A7 Gene

Solute carrier family 1 (glutamate transporter), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC1A7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for SLC1A7 Gene

GeneLoc Exon Structure for
SLC1A7
ECgene alternative splicing isoforms for
SLC1A7

Expression for SLC1A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC1A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC1A7 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC1A7 Gene



Protein tissue co-expression partners for SLC1A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC1A7 Gene:

SLC1A7

SOURCE GeneReport for Unigene cluster for SLC1A7 Gene:

Hs.104637

mRNA Expression by UniProt/SwissProt for SLC1A7 Gene:

O00341-EAA5_HUMAN
Tissue specificity: Expressed primarily in retina. Detectable in liver, heart, muscle and brain.

Evidence on tissue expression from TISSUES for SLC1A7 Gene

  • Eye(4.6)
genes like me logo Genes that share expression patterns with SLC1A7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC1A7 Gene

Orthologs for SLC1A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A7 33 34
  • 99.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A7 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC1A7 33 34
  • 88.93 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC1A7 34
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A7 33 34
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Slc1a7 33
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Slc1a7 33 16 34
  • 85.45 (n)
chicken
(Gallus gallus)
Aves SLC1A7 33 34
  • 72.62 (n)
lizard
(Anolis carolinensis)
Reptilia SLC1A7 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a7 33
  • 71.5 (n)
zebrafish
(Danio rerio)
Actinopterygii slc1a7b 34
  • 72 (a)
OneToMany
slc1a7a 33 34
  • 70.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 35
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-2 35
  • 53 (a)
Y53C12A.2 35
  • 46 (a)
K08F4.4 35
  • 43 (a)
T22E5.2 35
  • 43 (a)
R05G6.6 35
  • 41 (a)
W03G1.1 35
  • 36 (a)
Species where no ortholog for SLC1A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A7 Gene

ENSEMBL:
Gene Tree for SLC1A7 (if available)
TreeFam:
Gene Tree for SLC1A7 (if available)

Paralogs for SLC1A7 Gene

Paralogs for SLC1A7 Gene

(6) SIMAP similar genes for SLC1A7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC1A7: view

Variants for SLC1A7 Gene

Sequence variations from dbSNP and Humsavar for SLC1A7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs375136400 A colorectal cancer sample 53,142,329(+) GAGGC(A/G)CCGGG nc-transcript-variant, reference, missense
rs1000166233 -- 53,108,544(+) TGGAA(A/G)TCGTT intron-variant, utr-variant-3-prime
rs1000228355 -- 53,115,874(+) CCTGG(A/C)GCCCT intron-variant
rs1000264831 -- 53,137,201(+) AGATT(C/T)GCTTG intron-variant
rs1000328717 -- 53,124,243(+) AATAC(A/G)TACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A7 Gene

Variant ID Type Subtype PubMed ID
dgv21e201 CNV deletion 23290073
dgv275n54 CNV loss 21841781
dgv276n54 CNV loss 21841781
dgv277n54 CNV loss 21841781
dgv42e199 CNV deletion 23128226
dgv43e199 CNV deletion 23128226
dgv83n106 CNV deletion 24896259
dgv84n106 CNV deletion 24896259
dgv88e59 CNV duplication 20981092
esv21434 CNV gain+loss 19812545
esv2306191 CNV deletion 18987734
esv2671978 CNV deletion 23128226
esv2672076 CNV deletion 23128226
esv26895 CNV loss 19812545
esv2743348 CNV deletion 23290073
esv2748163 CNV deletion 23290073
esv2748174 CNV deletion 23290073
esv2748185 CNV deletion 23290073
esv3329716 CNV duplication 20981092
esv3561970 CNV deletion 23714750
esv3561982 CNV deletion 23714750
esv3561993 CNV deletion 23714750
esv3577856 CNV loss 25503493
esv3577857 CNV loss 25503493
esv3586062 CNV loss 21293372
esv3586063 CNV loss 21293372
esv3586064 CNV loss 21293372
esv998975 CNV insertion 20482838
nsv1001535 CNV gain 25217958
nsv1003159 CNV gain 25217958
nsv1010121 CNV gain 25217958
nsv1010473 CNV loss 25217958
nsv1075923 CNV deletion 25765185
nsv1075924 CNV deletion 25765185
nsv1115343 CNV duplication 24896259
nsv1116598 CNV tandem duplication 24896259
nsv1128594 CNV duplication 24896259
nsv1133852 CNV deletion 24896259
nsv1149544 CNV duplication 26484159
nsv160120 CNV insertion 16902084
nsv516780 CNV gain+loss 19592680
nsv522862 CNV loss 19592680
nsv546239 CNV loss 21841781
nsv546240 CNV loss 21841781
nsv546241 CNV loss 21841781
nsv546256 CNV loss 21841781
nsv822587 CNV gain 20364138
nsv822598 CNV loss 20364138
nsv950739 CNV deletion 24416366
nsv958856 CNV deletion 24416366

Variation tolerance for SLC1A7 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.30; 94.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC1A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC1A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A7 Gene

Disorders for SLC1A7 Gene

Relevant External Links for SLC1A7

Genetic Association Database (GAD)
SLC1A7
Human Genome Epidemiology (HuGE) Navigator
SLC1A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC1A7

No disorders were found for SLC1A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC1A7 Gene

Publications for SLC1A7 Gene

  1. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. (PMID: 9108121) Arriza JL … Amara SG (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 25 60
  2. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung SA … Criswell LA (PLoS genetics 2011) 3 45 60
  3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 45 60

Products for SLC1A7 Gene

Sources for SLC1A7 Gene

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