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Aliases for SLC1A7 Gene

Aliases for SLC1A7 Gene

  • Solute Carrier Family 1 Member 7 2 3 4 5
  • Solute Carrier Family 1 (Glutamate Transporter), Member 7 2 3
  • Retinal Glutamate Transporter 3 4
  • EAAT5 3 4
  • Excitatory Amino Acid Transporter 5 (Retinal Glutamate Transporter) 3
  • Excitatory Amino Acid Transporter 5 3
  • AAAT 3

External Ids for SLC1A7 Gene

Previous GeneCards Identifiers for SLC1A7 Gene

  • GC01M053188
  • GC01M052441
  • GC01M052911
  • GC01M052922
  • GC01M053264
  • GC01M053325
  • GC01M053552
  • GC01M051668

Summaries for SLC1A7 Gene

GeneCards Summary for SLC1A7 Gene

SLC1A7 (Solute Carrier Family 1 Member 7) is a Protein Coding gene. Among its related pathways are Neurotransmitter Release Cycle and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include L-glutamate transmembrane transporter activity and sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A7 Gene

  • Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

Tocris Summary for SLC1A7 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution.

Gene Wiki entry for SLC1A7 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A7 Gene

Genomics for SLC1A7 Gene

Regulatory Elements for SLC1A7 Gene

Enhancers for SLC1A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC1A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC1A7 Gene

Chromosome:
1
Start:
53,087,179 bp from pter
End:
53,142,632 bp from pter
Size:
55,454 bases
Orientation:
Minus strand

Genomic View for SLC1A7 Gene

Genes around SLC1A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC1A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC1A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A7 Gene

Proteins for SLC1A7 Gene

  • Protein details for SLC1A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00341-EAA5_HUMAN
    Recommended name:
    Excitatory amino acid transporter 5
    Protein Accession:
    O00341
    Secondary Accessions:
    • Q5VVZ0
    • Q969Z8
    • Q9BW45

    Protein attributes for SLC1A7 Gene

    Size:
    560 amino acids
    Molecular mass:
    60658 Da
    Quaternary structure:
    • Interacts with the PDZ domains of DLG4.

    Alternative splice isoforms for SLC1A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A7 Gene

Post-translational modifications for SLC1A7 Gene

  • Glycosylation at Asn 191
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC1A7 Gene

No data available for DME Specific Peptides for SLC1A7 Gene

Domains & Families for SLC1A7 Gene

Gene Families for SLC1A7 Gene

Protein Domains for SLC1A7 Gene

Graphical View of Domain Structure for InterPro Entry

O00341

UniProtKB/Swiss-Prot:

EAA5_HUMAN :
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily.
Family:
  • Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily.
genes like me logo Genes that share domains with SLC1A7: view

Function for SLC1A7 Gene

Molecular function for SLC1A7 Gene

UniProtKB/Swiss-Prot Function:
Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

Gene Ontology (GO) - Molecular Function for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS 9108121
GO:0005314 high-affinity glutamate transmembrane transporter activity TAS --
GO:0015171 amino acid transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC1A7: view
genes like me logo Genes that share phenotypes with SLC1A7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC1A7 Gene

Localization for SLC1A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A7 Gene COMPARTMENTS Subcellular localization image for SLC1A7 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC1A7: view

Pathways & Interactions for SLC1A7 Gene

genes like me logo Genes that share pathways with SLC1A7: view

Interacting Proteins for SLC1A7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360549%0d%0a9606.ENSP00000338770%0d%0a
Selected Interacting proteins: ENSP00000360549 O00341-EAA5_HUMAN for SLC1A7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport TAS 9108121
GO:0014047 glutamate secretion TAS --
GO:0089711 L-glutamate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC1A7: view

No data available for SIGNOR curated interactions for SLC1A7 Gene

Drugs & Compounds for SLC1A7 Gene

(9) Drugs for SLC1A7 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
DL-TBOA Pharma Inhibition, Inhibitor inhibitor of excitatory amino acid transporters, Selective non-transportable inhibitor of EAATs 0
[<sup>3</sup>H]D-aspartic acid Pharma 0
[<sup>3</sup>H]L-aspartic acid Pharma 0
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
7-Chlorokynurenic acid sodium salt Pharma Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) 0

(5) Additional Compounds for SLC1A7 Gene - From: IUPHAR, HMDB, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]ETB-TBOA
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
sodium
  • Sodium
  • Sodium ion
7440-23-5

(5) Tocris Compounds for SLC1A7 Gene

Compound Action Cas Number
7-Chlorokynurenic acid sodium salt Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) 1263094-00-3
Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake 52497-36-6
DL-TBOA Selective non-transportable inhibitor of EAATs 205309-81-5
L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor 64769-66-0
TFB-TBOA High affinity EAAT1 and EAAT2 blocker 480439-73-4
genes like me logo Genes that share compounds with SLC1A7: view

Transcripts for SLC1A7 Gene

Unigene Clusters for SLC1A7 Gene

Solute carrier family 1 (glutamate transporter), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for SLC1A7 Gene

GeneLoc Exon Structure for
SLC1A7
ECgene alternative splicing isoforms for
SLC1A7

Expression for SLC1A7 Gene

mRNA expression in normal human tissues for SLC1A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC1A7 Gene

This gene is overexpressed in Fetal Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC1A7 Gene



Protein tissue co-expression partners for SLC1A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC1A7 Gene:

SLC1A7

SOURCE GeneReport for Unigene cluster for SLC1A7 Gene:

Hs.104637

mRNA Expression by UniProt/SwissProt for SLC1A7 Gene:

O00341-EAA5_HUMAN
Tissue specificity: Expressed primarily in retina. Detectable in liver, heart, muscle and brain.
genes like me logo Genes that share expression patterns with SLC1A7: view

Primer Products

No data available for mRNA differential expression in normal tissues for SLC1A7 Gene

Orthologs for SLC1A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC1A7 34
  • 88.93 (n)
  • 91.61 (a)
SLC1A7 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A7 34
  • 87.86 (n)
  • 90.36 (a)
SLC1A7 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a7 34
  • 85.45 (n)
  • 90.16 (a)
Slc1a7 16
Slc1a7 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC1A7 34
  • 99.09 (n)
  • 99.15 (a)
SLC1A7 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a7 34
  • 86.67 (n)
  • 90 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC1A7 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A7 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC1A7 34
  • 72.62 (n)
  • 82.31 (a)
SLC1A7 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A7 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a7 34
  • 71.5 (n)
  • 81.16 (a)
zebrafish
(Danio rerio)
Actinopterygii slc1a7a 34
  • 70.3 (n)
  • 72.6 (a)
slc1a7a 35
  • 71 (a)
OneToMany
slc1a7b 35
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 36
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-2 36
  • 53 (a)
K08F4.4 36
  • 43 (a)
R05G6.6 36
  • 41 (a)
T22E5.2 36
  • 43 (a)
W03G1.1 36
  • 36 (a)
Y53C12A.2 36
  • 46 (a)
Species where no ortholog for SLC1A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A7 Gene

ENSEMBL:
Gene Tree for SLC1A7 (if available)
TreeFam:
Gene Tree for SLC1A7 (if available)

Paralogs for SLC1A7 Gene

Paralogs for SLC1A7 Gene

(6) SIMAP similar genes for SLC1A7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC1A7: view

Variants for SLC1A7 Gene

Sequence variations from dbSNP and Humsavar for SLC1A7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs375136400 A colorectal cancer sample 53,142,329(+) GAGGC(A/G)CCGGG nc-transcript-variant, reference, missense
rs1288401 - 53,088,082(+) CATCC(C/T)GCTCC nc-transcript-variant, reference, synonymous-codon, missense
rs768771 -- 53,128,725(-) CCCTG(A/C)CCTGG intron-variant
rs922682 -- 53,112,029(+) TGCAT(C/T)GATGG intron-variant
rs922683 -- 53,132,867(-) ACAAA(C/T)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A7 Gene

Variant ID Type Subtype PubMed ID
dgv21e201 CNV deletion 23290073
dgv275n54 CNV loss 21841781
dgv276n54 CNV loss 21841781
dgv277n54 CNV loss 21841781
dgv42e199 CNV deletion 23128226
dgv43e199 CNV deletion 23128226
dgv83n106 CNV deletion 24896259
dgv84n106 CNV deletion 24896259
dgv88e59 CNV duplication 20981092
esv21434 CNV gain+loss 19812545
esv2306191 CNV deletion 18987734
esv2671978 CNV deletion 23128226
esv2672076 CNV deletion 23128226
esv26895 CNV loss 19812545
esv2743348 CNV deletion 23290073
esv2748163 CNV deletion 23290073
esv2748174 CNV deletion 23290073
esv2748185 CNV deletion 23290073
esv3329716 CNV duplication 20981092
esv3561970 CNV deletion 23714750
esv3561982 CNV deletion 23714750
esv3561993 CNV deletion 23714750
esv3577856 CNV loss 25503493
esv3577857 CNV loss 25503493
esv3586062 CNV loss 21293372
esv3586063 CNV loss 21293372
esv3586064 CNV loss 21293372
esv998975 CNV insertion 20482838
nsv1001535 CNV gain 25217958
nsv1003159 CNV gain 25217958
nsv1010121 CNV gain 25217958
nsv1010473 CNV loss 25217958
nsv1075923 CNV deletion 25765185
nsv1075924 CNV deletion 25765185
nsv1115343 CNV duplication 24896259
nsv1116598 CNV tandem duplication 24896259
nsv1128594 CNV duplication 24896259
nsv1133852 CNV deletion 24896259
nsv1149544 CNV duplication 26484159
nsv160120 CNV insertion 16902084
nsv516780 CNV gain+loss 19592680
nsv522862 CNV loss 19592680
nsv546239 CNV loss 21841781
nsv546240 CNV loss 21841781
nsv546241 CNV loss 21841781
nsv546256 CNV loss 21841781
nsv822587 CNV gain 20364138
nsv822598 CNV loss 20364138
nsv950739 CNV deletion 24416366
nsv958856 CNV deletion 24416366

Variation tolerance for SLC1A7 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.30; 94.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC1A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC1A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A7 Gene

Disorders for SLC1A7 Gene

Relevant External Links for SLC1A7

Genetic Association Database (GAD)
SLC1A7
Human Genome Epidemiology (HuGE) Navigator
SLC1A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC1A7

No disorders were found for SLC1A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC1A7 Gene

Publications for SLC1A7 Gene

  1. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. (PMID: 9108121) Arriza J.L. … Amara S.G. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 25 65
  2. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung S.A. … Criswell L.A. (PLoS Genet. 2011) 3 46 65
  3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 65

Products for SLC1A7 Gene

Sources for SLC1A7 Gene

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