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Aliases for SLC1A7 Gene

Aliases for SLC1A7 Gene

  • Solute Carrier Family 1 (Glutamate Transporter), Member 7 2 3
  • Retinal Glutamate Transporter 3 4
  • EAAT5 3 4
  • Excitatory Amino Acid Transporter 5 (Retinal Glutamate Transporter) 3
  • Excitatory Amino Acid Transporter 5 3
  • Solute Carrier Family 1 Member 7 4
  • AAAT 3

External Ids for SLC1A7 Gene

Previous GeneCards Identifiers for SLC1A7 Gene

  • GC01M053188
  • GC01M052441
  • GC01M052911
  • GC01M052922
  • GC01M053264
  • GC01M053325
  • GC01M053552
  • GC01M051668

Summaries for SLC1A7 Gene

GeneCards Summary for SLC1A7 Gene

SLC1A7 (Solute Carrier Family 1 (Glutamate Transporter), Member 7) is a Protein Coding gene. Diseases associated with SLC1A7 include traumatic brain injury and brain injury. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transmission across Chemical Synapses. GO annotations related to this gene include L-glutamate transmembrane transporter activity and sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC1A3.

UniProtKB/Swiss-Prot for SLC1A7 Gene

  • Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing

Tocris Summary for SLC1A7 Gene

  • Glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina). Functions of glutamate transporters include regulation of excitatory neurotransmission, maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury.

Gene Wiki entry for SLC1A7 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC1A7 Gene

Genomics for SLC1A7 Gene

Regulatory Elements for SLC1A7 Gene

Genomic Location for SLC1A7 Gene

Start:
53,087,179 bp from pter
End:
53,142,632 bp from pter
Size:
55,454 bases
Orientation:
Minus strand

Genomic View for SLC1A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC1A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC1A7 Gene

Proteins for SLC1A7 Gene

  • Protein details for SLC1A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00341-EAA5_HUMAN
    Recommended name:
    Excitatory amino acid transporter 5
    Protein Accession:
    O00341
    Secondary Accessions:
    • Q5VVZ0
    • Q969Z8
    • Q9BW45

    Protein attributes for SLC1A7 Gene

    Size:
    560 amino acids
    Molecular mass:
    60658 Da
    Quaternary structure:
    • Interacts with the PDZ domains of DLG4

    Alternative splice isoforms for SLC1A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC1A7 Gene

Proteomics data for SLC1A7 Gene at MOPED

Post-translational modifications for SLC1A7 Gene

  • Glycosylation at Asn191
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC1A7 Gene

No data available for DME Specific Peptides for SLC1A7 Gene

Domains for SLC1A7 Gene

Gene Families for SLC1A7 Gene

Protein Domains for SLC1A7 Gene

Graphical View of Domain Structure for InterPro Entry

O00341

UniProtKB/Swiss-Prot:

EAA5_HUMAN :
  • O00341
Family:
  • Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A7 subfamily.
genes like me logo Genes that share domains with SLC1A7: view

Function for SLC1A7 Gene

Molecular function for SLC1A7 Gene

UniProtKB/Swiss-Prot Function: Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing

Gene Ontology (GO) - Molecular Function for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005313 L-glutamate transmembrane transporter activity TAS 9108121
GO:0017153 sodium:dicarboxylate symporter activity IEA --
genes like me logo Genes that share ontologies with SLC1A7: view

Phenotypes for SLC1A7 Gene

MGI mutant phenotypes for SLC1A7:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLC1A7:
genes like me logo Genes that share phenotypes with SLC1A7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC1A7 Gene

Localization for SLC1A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC1A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC1A7 Gene COMPARTMENTS Subcellular localization image for SLC1A7 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC1A7: view

Pathways for SLC1A7 Gene

genes like me logo Genes that share pathways with SLC1A7: view

Interacting Proteins for SLC1A7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360549%0d%0a9606.ENSP00000338770%0d%0a
Selected Interacting proteins: ENSP00000360549 O00341-EAA5_HUMAN for SLC1A7 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SLC1A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006835 dicarboxylic acid transport TAS 9108121
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0014047 glutamate secretion TAS --
genes like me logo Genes that share ontologies with SLC1A7: view

Compounds for SLC1A7 Gene

(5) Tocris Compounds for SLC1A7 Gene

Compound Action Cas Number
L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor [64769-66-0]
7-Chlorokynurenic acid sodium salt Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) [1263094-00-3]
Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake [52497-36-6]
DL-TBOA Selective non-transportable inhibitor of EAATs [205309-81-5]
TFB-TBOA High affinity EAAT1 and EAAT2 blocker [480439-73-4]

(2) HMDB Compounds for SLC1A7 Gene

Compound Synonyms Cas Number PubMed IDs
Chlorine
  • Cl2
16887-00-6
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SLC1A7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(4) IUPHAR Ligand for SLC1A7 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]ETB-TBOA None None 7.8
DL-TBOA Inhibitor Inhibition 6.9
[3H]L-aspartic acid None None
[3H]D-aspartic acid None None

(3) Novoseek inferred chemical compound relationships for SLC1A7 Gene

Compound -log(P) Hits PubMed IDs
glutamate 63.1 17
chloride 39.2 2
nmda 21.1 1
genes like me logo Genes that share compounds with SLC1A7: view

Transcripts for SLC1A7 Gene

Unigene Clusters for SLC1A7 Gene

Solute carrier family 1 (glutamate transporter), member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC1A7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for SLC1A7 Gene

GeneLoc Exon Structure for
SLC1A7
ECgene alternative splicing isoforms for
SLC1A7

Expression for SLC1A7 Gene

mRNA expression in normal human tissues for SLC1A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC1A7 Gene

SOURCE GeneReport for Unigene cluster for SLC1A7 Gene Hs.104637

mRNA Expression by UniProt/SwissProt for SLC1A7 Gene

O00341-EAA5_HUMAN
Tissue specificity: Expressed primarily in retina. Detectable in liver, heart, muscle and brain
genes like me logo Genes that share expressions with SLC1A7: view

No data available for mRNA differential expression in normal tissues for SLC1A7 Gene

Orthologs for SLC1A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC1A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC1A7 35
  • 99.09 (n)
  • 99.15 (a)
SLC1A7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC1A7 35
  • 88.93 (n)
  • 91.61 (a)
SLC1A7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC1A7 35
  • 87.86 (n)
  • 90.36 (a)
SLC1A7 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc1a7 35
  • 85.45 (n)
  • 90.16 (a)
Slc1a7 16
Slc1a7 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC1A7 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC1A7 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc1a7 35
  • 86.67 (n)
  • 90 (a)
chicken
(Gallus gallus)
Aves SLC1A7 35
  • 72.62 (n)
  • 82.31 (a)
SLC1A7 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC1A7 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc1a7 35
  • 71.5 (n)
  • 81.16 (a)
zebrafish
(Danio rerio)
Actinopterygii slc1a7a 35
  • 70.3 (n)
  • 72.6 (a)
slc1a7a 36
  • 71 (a)
OneToMany
slc1a7b 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eaat1 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea glt-2 37
  • 53 (a)
K08F4.4 37
  • 43 (a)
T22E5.2 37
  • 43 (a)
R05G6.6 37
  • 41 (a)
W03G1.1 37
  • 36 (a)
Y53C12A.2 37
  • 46 (a)
Species with no ortholog for SLC1A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC1A7 Gene

ENSEMBL:
Gene Tree for SLC1A7 (if available)
TreeFam:
Gene Tree for SLC1A7 (if available)

Paralogs for SLC1A7 Gene

Paralogs for SLC1A7 Gene

Selected SIMAP similar genes for SLC1A7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SLC1A7: view

Variants for SLC1A7 Gene

Sequence variations from dbSNP and Humsavar for SLC1A7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs768771 -- 53,128,725(-) CCCTG(A/C)CCTGG intron-variant
rs899975 -- 53,128,202(-) TCACC(A/G)CACCC intron-variant
rs899976 -- 53,128,141(-) TACAA(C/T)CAAGC intron-variant
rs922682 -- 53,112,029(+) TGCAT(C/T)GATGG intron-variant
rs922683 -- 53,132,867(-) ACAAA(C/T)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC1A7 Gene

Variant ID Type Subtype PubMed ID
nsv870582 CNV Gain 21882294
nsv522862 CNV Loss 19592680
nsv516780 CNV Gain+Loss 19592680
dgv226n71 CNV Loss 21882294
esv21434 CNV Gain+Loss 19812545
nsv822587 CNV Gain 20364138
esv2748163 CNV Deletion 23290073
esv2306191 CNV Deletion 18987734
esv998975 CNV Insertion 20482838
nsv160120 CNV Insertion 16902084
esv2748174 CNV Deletion 23290073
nsv871058 CNV Loss 21882294
esv2748185 CNV Deletion 23290073
dgv42e199 CNV Deletion 23128226
nsv822598 CNV Loss 20364138
dgv43e199 CNV Deletion 23128226
esv2671978 CNV Deletion 23128226
esv26895 CNV Loss 19812545
esv2743348 CNV Deletion 23290073
dgv31e201 CNV Deletion 23290073
esv2672076 CNV Deletion 23128226

Relevant External Links for SLC1A7 Gene

HapMap Linkage Disequilibrium report
SLC1A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC1A7 Gene

Disorders for SLC1A7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for SLC1A7 Gene including...

Search for SLC1A7 Gene in MalaCards »

Relevant External Links for SLC1A7

Genetic Association Database (GAD)
SLC1A7
Human Genome Epidemiology (HuGE) Navigator
SLC1A7
genes like me logo Genes that share disorders with SLC1A7: view

No data available for UniProtKB/Swiss-Prot for SLC1A7 Gene

Publications for SLC1A7 Gene

  1. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. (PMID: 9108121) Arriza J.L. … Amara S.G. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 25
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 48
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung S.A. … Criswell L.A. (PLoS Genet. 2011) 3 48
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48

Products for SLC1A7 Gene

Sources for SLC1A7 Gene

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